PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 30418757-4 2019 Here we show that, upon incorporation into short ssDNAs, the cytidine nucleoside analogue 2"-deoxyzebularine (dZ) becomes capable of inhibiting the catalytic activity of selected APOBEC variants derived from APOBEC3A, APOBEC3B, and APOBEC3G, supporting a mechanism in which ssDNA delivers dZ to the active site. cytidine nucleoside 61-80 apolipoprotein B mRNA editing enzyme catalytic subunit 3A Homo sapiens 208-216 32905646-1 2021 Reduced expression of the uptake transporter, OCTN1 (SLC22A4), has been reported as a strong predictor of poor event-free and overall survival in multiple cohorts of patients with acute myeloid leukemia (AML) receiving the cytidine nucleoside analog, cytarabine (Ara-C). cytidine nucleoside 223-242 solute carrier family 22 member 4 Homo sapiens 46-51 32905646-1 2021 Reduced expression of the uptake transporter, OCTN1 (SLC22A4), has been reported as a strong predictor of poor event-free and overall survival in multiple cohorts of patients with acute myeloid leukemia (AML) receiving the cytidine nucleoside analog, cytarabine (Ara-C). cytidine nucleoside 223-242 solute carrier family 22 member 4 Homo sapiens 53-60 30418757-4 2019 Here we show that, upon incorporation into short ssDNAs, the cytidine nucleoside analogue 2"-deoxyzebularine (dZ) becomes capable of inhibiting the catalytic activity of selected APOBEC variants derived from APOBEC3A, APOBEC3B, and APOBEC3G, supporting a mechanism in which ssDNA delivers dZ to the active site. cytidine nucleoside 61-80 apolipoprotein B mRNA editing enzyme catalytic subunit 3B Homo sapiens 218-226 30418757-4 2019 Here we show that, upon incorporation into short ssDNAs, the cytidine nucleoside analogue 2"-deoxyzebularine (dZ) becomes capable of inhibiting the catalytic activity of selected APOBEC variants derived from APOBEC3A, APOBEC3B, and APOBEC3G, supporting a mechanism in which ssDNA delivers dZ to the active site. cytidine nucleoside 61-80 apolipoprotein B mRNA editing enzyme catalytic subunit 3G Homo sapiens 232-240 27160178-1 2016 Human cytidine deaminase (hCDA) is a biomedically important enzyme able to inactivate cytidine nucleoside analogs such as the antileukemic agent cytosine arabinoside (AraC) and thereby limit antineoplastic efficacy. cytidine nucleoside 86-105 cytidine deaminase Homo sapiens 6-24 28209616-3 2017 Through transcriptomic profiling, we determined that low expression of the ergothioneine transporter OCTN1 (SLC22A4; ETT) strongly predicts poor event-free survival and overall survival in multiple cohorts of AML patients receiving treatment with the cytidine nucleoside analogue cytarabine. cytidine nucleoside 251-270 solute carrier family 22 member 4 Homo sapiens 101-106 28209616-3 2017 Through transcriptomic profiling, we determined that low expression of the ergothioneine transporter OCTN1 (SLC22A4; ETT) strongly predicts poor event-free survival and overall survival in multiple cohorts of AML patients receiving treatment with the cytidine nucleoside analogue cytarabine. cytidine nucleoside 251-270 solute carrier family 22 member 4 Homo sapiens 108-115 27160178-1 2016 Human cytidine deaminase (hCDA) is a biomedically important enzyme able to inactivate cytidine nucleoside analogs such as the antileukemic agent cytosine arabinoside (AraC) and thereby limit antineoplastic efficacy. cytidine nucleoside 86-105 cytidine deaminase Homo sapiens 26-30 27036028-3 2016 We applied this approach to identify functional disparities between two cytidine nucleoside analogs: azacytidine (AZA) and decitabine (DAC). cytidine nucleoside 72-91 arylacetamide deacetylase Homo sapiens 135-138 20126405-1 2010 BACKGROUND: The cytidine nucleoside analogs azacitidine (AZA) and decitabine (DAC) are used for the treatment of patients with myelodysplastic syndromes and acute myeloid leukemia (AML). cytidine nucleoside 16-35 arylacetamide deacetylase Homo sapiens 78-81