PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2532461-0	1989	Cilazapril: a new non-thiol-containing angiotensin-converting enzyme inhibitor.	Sulfhydryl Compounds	22-27	angiotensin I converting enzyme	Homo sapiens	39-68
2557847-3	1989	Inactivation of alpha 1-antiproteinase by radiolytically-generated .OH under anoxic conditions was decreased by adding a range of anti-inflammatory drugs to the reaction mixtures, including the thiol compound penicillamine.	Sulfhydryl Compounds	194-199	serpin family A member 1	Homo sapiens	16-38
2510598-1	1989	Incubation of human placental aldose reductase (EC 1.1.1.21) with the sulfhydryl oxidizing reagents 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB) and N-ethylmaleimide (NEM) results in a biexponential loss of catalytic activity.	Sulfhydryl Compounds	70-80	aldo-keto reductase family 1 member B	Homo sapiens	30-46
2611226-8	1989	Quantitation of the total free thiols of modified PEPCK shows that 2 mol of cysteine is lost per mole of inactivated enzyme.	Sulfhydryl Compounds	31-37	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	50-55
2605244-1	1989	Thiol-disulfide exchange reactions between myosin and 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB) lead to the formation of 5-thio-2-nitrobenzoic acid (TNB)-mixed disulfides as well as to protein disulfide bonds.	Sulfhydryl Compounds	0-5	myosin heavy chain 14	Homo sapiens	43-49
2512929-11	1989	In addition, established effects of sulfhydryl-reactive compounds on the MFO system, i.e. inhibition of NADPH-cytochrome c reductase and conversion of cytochrome P-450 to cytochrome P-420, were not observed after addition of helenalin (1.0 mM) or alantolactone (0.5 mM) to mouse hepatic microsomes.	Sulfhydryl Compounds	36-46	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	151-167
2550456-4	1989	2) Fluorescence measurements and iodoacetate trapping of free sulfhydryls show that the disulfide bonds of MetSO-RNase A, in which the 4 methionine residues are oxidized to the sulfoxide, are reduced by 2 mM dithiothreitol (DTT) in standard Ub conjugation assays so that this derivative also is unfolded.	Sulfhydryl Compounds	62-73	ribonuclease pancreatic	Bos taurus	113-120
2632051-12	1989	Regucalcin (2.0 microM)-induced release of 45Ca2+ was not blocked by the presence of the protein thiol-protecting agent dithiothreitol (0.1 mM).	Sulfhydryl Compounds	97-102	regucalcin	Rattus norvegicus	0-10
2804091-10	1989	These mechanisms are different from the known damage to red cells caused by the binding of Fe(III) or Cu(II) to the thiol groups of glucose-6-phosphate dehydrogenase.	Sulfhydryl Compounds	116-121	glucose-6-phosphate dehydrogenase	Homo sapiens	132-165
2610937-1	1989	For a selective covalent linkage of muramyl-peptides with human-little-gastrin the maleimide-thiol reaction principle was adopted.	Sulfhydryl Compounds	93-98	gastrin	Homo sapiens	71-78
2808367-8	1989	TPCK and N-ethylmaleimide inactivated TFIIIC solely through thiol group modification, since prior modification with the reversible thiol reagent 2,2"-dithiopyridine prevented permanent inactivation.	Sulfhydryl Compounds	60-65	general transcription factor IIIC subunit 1	Homo sapiens	38-44
2808367-9	1989	The involvement of reduced thiol groups in the specific binding of TFIIIC to the VAI gene was further indicated by an increase in TFIIIC binding activity upon addition of dithiothreitol.	Sulfhydryl Compounds	27-32	general transcription factor IIIC subunit 1	Homo sapiens	67-73
2808367-9	1989	The involvement of reduced thiol groups in the specific binding of TFIIIC to the VAI gene was further indicated by an increase in TFIIIC binding activity upon addition of dithiothreitol.	Sulfhydryl Compounds	27-32	general transcription factor IIIC subunit 1	Homo sapiens	130-136
2512907-2	1989	Stimulation of 5-lipoxygenase activity by the 5-hydroperoxyeicosatetraenoic acid (5-HPETE) reaction product was strongly dependent on the presence of thiol compounds.	Sulfhydryl Compounds	150-155	arachidonate 5-lipoxygenase	Rattus norvegicus	15-29
2512907-9	1989	These results provide evidence for an hydroperoxide activation of 5-lipoxygenase which is not product-specific and is modulated by thiol levels and several soluble components of the leukocytes.	Sulfhydryl Compounds	131-136	arachidonate 5-lipoxygenase	Rattus norvegicus	66-80
2478324-2	1989	We investigated whether chemical modification of this thiol group affected the serological reactions of B27.	Sulfhydryl Compounds	54-59	melanocortin 2 receptor accessory protein	Homo sapiens	104-107
2477378-2	1989	The two classes of light chains in vertebrate fast muscle myosin have been selectively labeled with the thiol specific reagent 5-(iodoacetamido) fluorescein to determine their location in the myosin head.	Sulfhydryl Compounds	104-109	myosin heavy chain 14	Homo sapiens	58-64
2813355-3	1989	The chicken intestinal epithelial cell MHC shows overall similarity in primary structure to other MHCs in the areas of the reactive thiol residues and in areas contributing to the ATP binding site and actin binding site.	Sulfhydryl Compounds	132-137	myosin, heavy chain 15	Gallus gallus	39-42
2819070-0	1989	Catalysis of thiol/disulfide exchange: single-turnover reduction of protein disulfide-isomerase by glutathione and catalysis of peptide disulfide reduction.	Sulfhydryl Compounds	13-18	prolyl 4-hydroxylase subunit beta	Bos taurus	68-95
2548765-5	1989	Endothelial cells stimulated with bradykinin or exposed to stirred medium expressed a dose-dependent inhibition of platelet aggregation that was potentiated by the reduced thiol, N-acetylcysteine.	Sulfhydryl Compounds	172-177	kininogen 1	Bos taurus	34-44
2811360-4	1989	The steroid-binding capacity of the glucocorticoid receptor of the 100,000 g supernatant of rat liver homogenate is preserved/restored by sulfhydryl compounds containing a mercaptoethylamine or mercaptopropylamine subunit.	Sulfhydryl Compounds	138-158	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	36-59
2478324-0	1989	Status of an unpaired thiol group on the HLA-B27 epitope.	Sulfhydryl Compounds	22-27	major histocompatibility complex, class I, B	Homo sapiens	41-48
2478324-3	1989	B27-positive cells were treated with thiol-blocking agents and then tested for recognizable B27 expression.	Sulfhydryl Compounds	37-42	melanocortin 2 receptor accessory protein	Homo sapiens	0-3
2478324-7	1989	This suggests that a proportion of HLA-B27 molecules have a free, reactive thiol at the antibody-defined epitope.	Sulfhydryl Compounds	75-80	major histocompatibility complex, class I, B	Homo sapiens	35-42
2545706-12	1989	Although spin-trapped adducts can be destroyed by a high concentration of superoxide, or by lower concentrations of superoxide in the presence of thiol-containing compounds, our results demonstrate that such decomposition does not interfere with the ability of the spin-trapping method to detect hydroxyl radical generated by human neutrophils.	Sulfhydryl Compounds	146-151	spindlin 1	Homo sapiens	9-13
2511568-5	1989	It was shown that sulphydryl compounds such as cysteine and glutathione have an inhibitory effect on tyrosinase, and it is possible that the elevated levels of SH-compounds are responsible for a reduction in tyrosinase activity in agouti mice.	Sulfhydryl Compounds	18-28	tyrosinase	Mus musculus	101-111
2511568-5	1989	It was shown that sulphydryl compounds such as cysteine and glutathione have an inhibitory effect on tyrosinase, and it is possible that the elevated levels of SH-compounds are responsible for a reduction in tyrosinase activity in agouti mice.	Sulfhydryl Compounds	18-28	tyrosinase	Mus musculus	208-218
2550091-2	1989	Human plasma fibronectin is a dimer consisting of two subunits; each contains two cryptic thiol groups that were selectively labeled with an 15N,2H-maleimide spin label.	Sulfhydryl Compounds	90-95	fibronectin 1	Homo sapiens	13-24
2550091-6	1989	Parallel experiments using various fibronectin fragments showed that the 1.37-microseconds component is associated with the label attached onto the thiol located in between the DNA-binding and the cell-binding domains, and the 4.53-microseconds component is associated with the label attached onto the thiol located within the carboxyl-terminal fibrin-binding domain.	Sulfhydryl Compounds	148-153	fibronectin 1	Homo sapiens	35-46
2757638-9	1989	Both CT40 and CB40 contain a reactive thiol group, but these thiols are apparently in different environments as judged by the responses of attached fluorescent labels to calmodulin-binding.	Sulfhydryl Compounds	61-67	calmodulin 2	Gallus gallus	170-180
2780547-6	1989	Phenylmethylsulfonyl fluoride, a serine enzyme inhibitor, was inhibitory to the expressed CEH activity, whereas p-chloromercuribenzoate (up to 5 mM), a potent thiol-blocking agent, did not significantly inhibit the expressed activity.	Sulfhydryl Compounds	159-164	epoxide hydrolase 2	Rattus norvegicus	90-93
2528460-2	1989	After reduction of the interchange disulfide bonds of these fragments by dithiothreitol, a thiol-disulfide interchain reagent, 5,5"-dithiobis-2-nitrobenzoic acid, was added to convert the free SH groups of one of the Fab" fragments to mixed disulfide derivatives.	Sulfhydryl Compounds	91-96	FA complementation group B	Homo sapiens	217-220
2501302-4	1989	In the presence of 1.3 M urea, however, the single thiol of the reduced enzyme reacts with phenylmercuric acetate with a t1/2 of 3 min.	Sulfhydryl Compounds	51-56	interleukin 1 receptor like 1	Homo sapiens	121-130
2473918-0	1989	Identification of thiol groups and a disulfide crosslink site in bovine myelin proteolipid protein.	Sulfhydryl Compounds	18-23	proteolipid protein 1	Bos taurus	72-98
2753048-1	1989	It has been shown by polarization microfluorimetry that phosphorylation of myosin light chain 2, in stretched single glycerinated fibers of rabbit skeletal muscle, results in changes in polarized fluorescence anisotropy of both the tryptophan residues of myosin molecules and the fluorescent label, N-iodoacetyl-N"-(5-sulfo-1-naphthyl)ethylenediamine, associated with the fast-reacting thiol group in myosin heads.	Sulfhydryl Compounds	386-391	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	75-95
2550062-0	1989	Thiol and amino analogues as alternate substrates for glycerokinase from Candida mycoderma.	Sulfhydryl Compounds	0-5	glycerol kinase	Homo sapiens	54-67
2550062-1	1989	The kinetic and catalytic mechanism of glycerokinase from Candida mycoderma was examined with thiol and amino analogues of glycerol and with MgAMPPCP, an analogue of MgATP.	Sulfhydryl Compounds	94-99	glycerol kinase	Homo sapiens	39-52
2473918-2	1989	Thus localization of disulfide and thiol groups is a key to understanding the conformation and orientation of myelin proteolipid protein (PLP) in the myelin membrane.	Sulfhydryl Compounds	35-40	proteolipid protein 1	Bos taurus	110-136
2543682-8	1989	Analogous to p21ras, the binding activities of 9 of the 11 species were sensitive to the thiol reagent N-ethylmaleimide, and six peaks possessed detectable GTPase activity in the absence of extrinsic factors.	Sulfhydryl Compounds	89-94	Harvey rat sarcoma virus oncogene	Mus musculus	13-19
2473918-2	1989	Thus localization of disulfide and thiol groups is a key to understanding the conformation and orientation of myelin proteolipid protein (PLP) in the myelin membrane.	Sulfhydryl Compounds	35-40	proteolipid protein 1	Bos taurus	138-141
2791215-5	1989	Agents known to provoke oxidative alteration of the thiol-redox status in cells, also caused a similar effect on the induction and stability of ODC.	Sulfhydryl Compounds	52-57	ornithine decarboxylase 1	Homo sapiens	144-147
2546149-6	1989	The cysteinyl residues 121 and 215 of PTPase 1B are conserved among all members of the family and are candidates for involvement in catalysis since PTPase 1B is inactivated by thiol modifying reagents.	Sulfhydryl Compounds	176-181	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	38-47
2546149-6	1989	The cysteinyl residues 121 and 215 of PTPase 1B are conserved among all members of the family and are candidates for involvement in catalysis since PTPase 1B is inactivated by thiol modifying reagents.	Sulfhydryl Compounds	176-181	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	148-157
2735946-5	1989	These data clearly show that auranofin inhibits the catalytic activity of PKC, probably by interacting with thiol groups.	Sulfhydryl Compounds	108-113	proline rich transmembrane protein 2	Homo sapiens	74-77
2588336-1	1989	New disulphides synthesized on the basis of dithiocarboxylic acid derivatives and heterocyclic thiols containing the fluorine atoms were studied as applied to inhibit aldehyde dehydrogenase (ALDH) isozymes of the rat liver mitochondria.	Sulfhydryl Compounds	95-101	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	167-189
2588336-1	1989	New disulphides synthesized on the basis of dithiocarboxylic acid derivatives and heterocyclic thiols containing the fluorine atoms were studied as applied to inhibit aldehyde dehydrogenase (ALDH) isozymes of the rat liver mitochondria.	Sulfhydryl Compounds	95-101	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	191-195
2785556-0	1989	Thiol-sensitive mast cell lines derived from mouse bone marrow respond to a mast cell growth-enhancing activity different from both IL-3 and IL-4.	Sulfhydryl Compounds	0-5	interleukin 3	Mus musculus	132-136
2722851-1	1989	The inhibition of the autophosphorylation of the heme-regulated eukaryotic initiation factor (eIF)-2 alpha kinase (HRI) by hemin is very similar to that produced by thiol oxidation by diamide.	Sulfhydryl Compounds	165-170	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	115-118
2765518-1	1989	Resonance energy transfer between the reactive thiols of rabbit muscle creatine kinase was evaluated.	Sulfhydryl Compounds	47-53	creatine kinase M-type	Oryctolagus cuniculus	64-86
2656672-2	1989	The ionization of at least three active site amino acid side chains can influence the spectra over the range of pH studied: the two nascent thiols (interchange thiol and electron transfer thiol) and the histidine residue which acts as the base catalyst in lipoamide dehydrogenase and the acid catalyst in glutathione reductase thiol-disulfide interchange reactions.	Sulfhydryl Compounds	140-146	dihydrolipoamide dehydrogenase	Sus scrofa	256-279
2656672-2	1989	The ionization of at least three active site amino acid side chains can influence the spectra over the range of pH studied: the two nascent thiols (interchange thiol and electron transfer thiol) and the histidine residue which acts as the base catalyst in lipoamide dehydrogenase and the acid catalyst in glutathione reductase thiol-disulfide interchange reactions.	Sulfhydryl Compounds	140-145	dihydrolipoamide dehydrogenase	Sus scrofa	256-279
2656672-2	1989	The ionization of at least three active site amino acid side chains can influence the spectra over the range of pH studied: the two nascent thiols (interchange thiol and electron transfer thiol) and the histidine residue which acts as the base catalyst in lipoamide dehydrogenase and the acid catalyst in glutathione reductase thiol-disulfide interchange reactions.	Sulfhydryl Compounds	160-165	dihydrolipoamide dehydrogenase	Sus scrofa	256-279
2656672-2	1989	The ionization of at least three active site amino acid side chains can influence the spectra over the range of pH studied: the two nascent thiols (interchange thiol and electron transfer thiol) and the histidine residue which acts as the base catalyst in lipoamide dehydrogenase and the acid catalyst in glutathione reductase thiol-disulfide interchange reactions.	Sulfhydryl Compounds	160-165	dihydrolipoamide dehydrogenase	Sus scrofa	256-279
2656672-5	1989	Like papain and glyceraldehyde-3-phosphate dehydrogenase, alkylated glutathione reductase showed two macroscopic pKa values, at pH 3.7 and pH 9.1, and by analogy, these were associated primarily with the thiol and the imidazole, respectively.	Sulfhydryl Compounds	204-209	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	113-116
2548598-1	1989	Changes in local environment of the free sulfhydryl groups in plasma fibronectin upon adsorption of the protein to polystyrene beads have been examined by electron spin resonance (ESR) spin-label spectroscopy.	Sulfhydryl Compounds	41-51	fibronectin 1	Homo sapiens	69-80
2730902-1	1989	Using a fluorogenic thiol reagent, N-(1-pyrene)maleimide (NPM), we have examined of lipid peroxidation on the microenvironment around SH groups of the membrane proteins in porcine intestinal brush-border membrane vesicles.	Sulfhydryl Compounds	20-25	nucleophosmin 1	Homo sapiens	58-61
2475483-5	1989	The time course of the reaction of rabbit alpha-2-macroglobulin with methylamine was studied by measuring (i) the generation of thiol groups, (ii) the decrease in trypsin-inhibiting activity with remazol brilliant blue hide powder as the substrate, and (iii) the decrease in trypsin-protein amidase activity.	Sulfhydryl Compounds	128-133	LOW QUALITY PROTEIN: alpha-2-macroglobulin	Oryctolagus cuniculus	42-63
2653221-1	1989	Results obtained with isolated intact chloroplasts maintained aerobically under light and dark conditions confirm earlier findings with reconstituted enzyme assays and indicate that the ferredoxin/thioredoxin system functions as a light-mediated regulatory thiol chain.	Sulfhydryl Compounds	257-262	thioredoxin	Homo sapiens	197-208
2653221-4	1989	The findings indicate that each member of the ferredoxin/thioredoxin system containing a catalytically active thiol group is reduced in isolated intact chloroplasts after a 2-min illumination.	Sulfhydryl Compounds	110-115	thioredoxin	Homo sapiens	57-68
2785556-0	1989	Thiol-sensitive mast cell lines derived from mouse bone marrow respond to a mast cell growth-enhancing activity different from both IL-3 and IL-4.	Sulfhydryl Compounds	0-5	interleukin 4	Mus musculus	141-145
2658980-9	1989	Free thiol groups in the insulin receptor and disulphide bonds between the alpha-subunits are not essential to this process.	Sulfhydryl Compounds	5-10	insulin receptor	Rattus norvegicus	25-41
2785556-4	1989	We show that these thiol-sensitive mast cell lines respond to a mast cell growth enhancing activity (MEA) present in spleen cell-conditioned medium and acting in concert with IL-3.	Sulfhydryl Compounds	19-24	interleukin 3	Mus musculus	175-179
2466831-12	1989	These findings indicate that "F" alpha 2M interacts with IL-1 beta through a thiol-disulfide exchange reaction.	Sulfhydryl Compounds	77-82	alpha-2-macroglobulin	Homo sapiens	33-41
2786856-2	1989	The present study was performed with the aim to evaluate the protective activity of erdosteine, a novel thiol derivative endowed with reducing properties, against the functional inactivation of alpha 1-AT induced by smoke.	Sulfhydryl Compounds	104-109	serpin family A member 1	Homo sapiens	194-204
2466831-12	1989	These findings indicate that "F" alpha 2M interacts with IL-1 beta through a thiol-disulfide exchange reaction.	Sulfhydryl Compounds	77-82	interleukin 1 beta	Homo sapiens	57-66
2495799-7	1989	Thiol containing compounds are able to abolish the lag period due to the ability of these compounds to reduce met-tyrosinase directly.	Sulfhydryl Compounds	0-5	tyrosinase	Homo sapiens	114-124
2930195-6	1989	These results indicate that microsomal glutathione S-transferase activity may be regulated by reversible thiol/disulfide exchange and that mixed disulfide formation of the microsomal glutathione S-transferase with glutathione disulfide may be catalyzed enzymatically in vivo.	Sulfhydryl Compounds	105-110	hematopoietic prostaglandin D synthase	Rattus norvegicus	39-64
2930199-7	1989	By titrating the free thiol residues of partially inactivated GAPDH, it was found that both pentalenolactone and pentalenolactone methyl ester react with all four Cys-SH residues of the tetrameric GAPDH.	Sulfhydryl Compounds	22-27	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	62-67
2930199-7	1989	By titrating the free thiol residues of partially inactivated GAPDH, it was found that both pentalenolactone and pentalenolactone methyl ester react with all four Cys-SH residues of the tetrameric GAPDH.	Sulfhydryl Compounds	22-27	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	197-202
2930195-0	1989	Regulation of rat liver microsomal glutathione S-transferase activity by thiol/disulfide exchange.	Sulfhydryl Compounds	73-78	hematopoietic prostaglandin D synthase	Rattus norvegicus	35-60
2917017-7	1989	Bovine serum albumin at physiological concentrations and sulfhydryl compounds such as dithioerythritol are effective in preventing this cytochrome P-450 inactivation by ebselen.	Sulfhydryl Compounds	57-67	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	136-152
2719637-0	1989	Involvement of thiol transferase- and thioredoxin-dependent systems in the protection of "essential" thiol groups of ornithine decarboxylase.	Sulfhydryl Compounds	15-20	ornithine decarboxylase 1	Rattus norvegicus	117-140
2719637-1	1989	Ornithine decarboxylase (ODC), an enzyme with "essential" thiol group(s), may be inactivated in vitro by removal of thiol reducing agents and re-activated by soluble factors from rat liver in the presence of NADPH or GSH.	Sulfhydryl Compounds	58-63	ornithine decarboxylase 1	Rattus norvegicus	0-23
2719637-1	1989	Ornithine decarboxylase (ODC), an enzyme with "essential" thiol group(s), may be inactivated in vitro by removal of thiol reducing agents and re-activated by soluble factors from rat liver in the presence of NADPH or GSH.	Sulfhydryl Compounds	58-63	ornithine decarboxylase 1	Rattus norvegicus	25-28
2719637-1	1989	Ornithine decarboxylase (ODC), an enzyme with "essential" thiol group(s), may be inactivated in vitro by removal of thiol reducing agents and re-activated by soluble factors from rat liver in the presence of NADPH or GSH.	Sulfhydryl Compounds	116-121	ornithine decarboxylase 1	Rattus norvegicus	0-23
2719637-1	1989	Ornithine decarboxylase (ODC), an enzyme with "essential" thiol group(s), may be inactivated in vitro by removal of thiol reducing agents and re-activated by soluble factors from rat liver in the presence of NADPH or GSH.	Sulfhydryl Compounds	116-121	ornithine decarboxylase 1	Rattus norvegicus	25-28
2524213-1	1989	We describe a protocol for the selective covalent labeling of the sulfhydryl 2 (SH2) on the myosin cross-bridge in glycerinated muscle fibers using the sulfhydryl-selective label 4-[N-[(iodoacetoxy)ethyl]-N-methylamino]-7-nitrobenz-2-oxa-1,3-diazole (IANBD).	Sulfhydryl Compounds	66-76	myosin heavy chain 14	Homo sapiens	92-98
2499573-3	1989	Spirulina glutathione reductase was covalently bound to Thiopropyl-Sepharose 6B in the presence of 8M urea through thiol-disulfide exchange.	Sulfhydryl Compounds	115-120	glutathione-disulfide reductase	Homo sapiens	10-31
2662597-4	1989	In peritoneal macrophages administration of sheep erythrocytes led to 2-5-fold decrease in activity of all the lysosomal proteinases studied (cathepsins A, B, C, D, H and L), however Vi-antigen exhibited direct dose-dependent effect on activity of cathepsins A, B, D and L. The data obtained suggest that T-independent reactions of the immune system were realized via thiol-dependent lysosomal proteinases.	Sulfhydryl Compounds	368-373	lysosomal protective protein	Ovis aries	142-193
2719637-6	1989	In an attempt to investigate the physiological role of the "essential" thiol group(s) of ODC, erythroleukaemia cells were incubated with NN-bis-(2-chloroethyl)-N"-nitrosourea, t-butyl hydroperoxide and vinblastine, which are known to increase the cellular GSSG/GSH ratio, azelaic acid, an inhibitor of thioredoxin reductase, and sodium arsenite, a strong inhibitor of the ODC-re-activating factors.	Sulfhydryl Compounds	71-76	ornithine decarboxylase 1	Rattus norvegicus	89-92
2540931-18	1989	We conclude that the thiol group is possibly involved in the mechanism of the beneficial effects of some angiotensin converting enzyme inhibitors on the progression of chronic renal failure exacerbated by hypertension.	Sulfhydryl Compounds	21-26	angiotensin I converting enzyme	Rattus norvegicus	105-134
2657416-6	1989	Thiol-oxidizing agents cause contraction damage in skinned muscle that resembles the quasirigor induced in myosin by N-ethylmaleimide.	Sulfhydryl Compounds	0-5	myosin heavy chain 14	Homo sapiens	107-113
2664476-6	1989	Analysis of RNA pulse-labeled with thiouridine followed by purification of the thiol-labeled RNA using mercurated agarose indicated that GH probably acts by increasing IGF-I transcription.	Sulfhydryl Compounds	79-84	insulin-like growth factor 1	Rattus norvegicus	168-173
2918027-9	1989	Hydrolysis of ester-like bonds with neutral hydroxylamine removes the bound fatty acid and exposes new thiol groups on GAP-43, suggesting that fatty acid is attached to the protein"s only two cysteine residues, located in a short hydrophobic domain at the amino terminus.	Sulfhydryl Compounds	103-108	growth associated protein 43	Rattus norvegicus	119-125
2713361-3	1989	Positions of 13C magnetic resonances and UV absorption maxima of the above complexes and comparison with those of adenosine deaminase complexes strongly suggest that purine ribonucleoside is bound by adenosine deaminase as the 1,6 covalent hydrate, not as a covalently bonded complex formed by addition of a thiol group at the active site.	Sulfhydryl Compounds	308-313	adenosine deaminase	Homo sapiens	114-133
2713361-3	1989	Positions of 13C magnetic resonances and UV absorption maxima of the above complexes and comparison with those of adenosine deaminase complexes strongly suggest that purine ribonucleoside is bound by adenosine deaminase as the 1,6 covalent hydrate, not as a covalently bonded complex formed by addition of a thiol group at the active site.	Sulfhydryl Compounds	308-313	adenosine deaminase	Homo sapiens	200-219
2653437-12	1989	The fluorescence, but not the absorbance, of the enzyme-bound FAD was found to be highly dependent on the redox state of the C-terminal thiols.	Sulfhydryl Compounds	136-142	BRCA2 DNA repair associated	Homo sapiens	62-65
2468964-2	1989	The present study was performed to elucidate if large oral doses of N-acetylcysteine (NAC, 2,400 mg X 2), a donor of sulfhydryl groups, given together with a single oral dose of the long-acting nitrate, isosorbide-5-mononitrate (5-ISMN, 60 mg), would modify the nitrate effect evaluated by exercise testing before and after additional sublingual doses of nitroglycerin (NTG).	Sulfhydryl Compounds	117-127	NACC family member 2	Homo sapiens	68-103
2536068-4	1989	The enzyme is also inactivated by thiol-blocking reagents; with respect to inactivation by sodium pyrophosphate, sorbitol dehydrogenase is different from closely related alcohol dehydrogenase.	Sulfhydryl Compounds	34-39	sorbitol dehydrogenase	Bos taurus	113-135
2536279-1	1989	Captopril, an angiotensin converting enzyme (ACE) inhibitor, was hypothesized to be a potential scavenger of free radicals because of the presence of a thiol group.	Sulfhydryl Compounds	152-157	angiotensin I converting enzyme	Homo sapiens	14-43
2536279-1	1989	Captopril, an angiotensin converting enzyme (ACE) inhibitor, was hypothesized to be a potential scavenger of free radicals because of the presence of a thiol group.	Sulfhydryl Compounds	152-157	angiotensin I converting enzyme	Homo sapiens	45-48
2643381-6	1989	Inhibition of proteinase activity by thiol reagents supports the suggestion that the enzyme is a cysteine proteinase but there is some evidence that it may be a serine proteinase and the catalytic mechanism is at present unknown.	Sulfhydryl Compounds	37-42	endogenous retrovirus group K member 10	Homo sapiens	14-24
2751245-3	1989	Biochemical studies showed that thiol groups participate in the mobility of the SP fast band; furthermore, an interchange of the bands of SP-SORD was observed which suggests that the isozymes are due to conformational isomerism or to molecular aggregates.	Sulfhydryl Compounds	32-37	sorbitol dehydrogenase	Homo sapiens	141-145
2643381-6	1989	Inhibition of proteinase activity by thiol reagents supports the suggestion that the enzyme is a cysteine proteinase but there is some evidence that it may be a serine proteinase and the catalytic mechanism is at present unknown.	Sulfhydryl Compounds	37-42	endogenous retrovirus group K member 10	Homo sapiens	106-116
2643381-6	1989	Inhibition of proteinase activity by thiol reagents supports the suggestion that the enzyme is a cysteine proteinase but there is some evidence that it may be a serine proteinase and the catalytic mechanism is at present unknown.	Sulfhydryl Compounds	37-42	endogenous retrovirus group K member 10	Homo sapiens	106-116
2904433-8	1988	These results show that F1 (and/or OSCP) protects Fo thiols from diamide and are substantiated by the finding that the oligomycin sensitivity of ATP hydrolysis activity of isolated Complex V was also unaltered by diamide.	Sulfhydryl Compounds	53-59	ATP synthase peripheral stalk subunit OSCP	Homo sapiens	35-39
2548550-8	1989	Determination of the positions of the thiol group conferring best inhibition in the active site of ACE permitted the probable location of the active site zinc ion to be identified.	Sulfhydryl Compounds	38-43	angiotensin I converting enzyme	Homo sapiens	99-102
2548550-9	1989	The intention was to replace the thiol side chain with a homophenylalanine unit to bind to the zinc ion and also to occupy the S1 site which fits the Phe8 side chain of angiotensin I.	Sulfhydryl Compounds	33-38	angiotensinogen	Homo sapiens	169-182
2575561-7	1989	These observations indicate that autoxidation of ascorbic acid or thiols present with the guanylate cyclase preparation leads to generation of H2O2, and its metabolism by bovine liver catalase mediates the concomitant activation of guanylate cyclase.	Sulfhydryl Compounds	66-72	catalase	Bos taurus	184-192
2619767-2	1989	The process is catalysed within the lumen of the endoplasmic reticulum by the enzyme protein disulphide-isomerase (PDI), which is abundant in secretory cells and catalyses thiol: protein-disulphide interchange in vitro with very broad protein substrate specificity.	Sulfhydryl Compounds	172-177	prolyl 4-hydroxylase subunit beta	Homo sapiens	85-113
2619767-2	1989	The process is catalysed within the lumen of the endoplasmic reticulum by the enzyme protein disulphide-isomerase (PDI), which is abundant in secretory cells and catalyses thiol: protein-disulphide interchange in vitro with very broad protein substrate specificity.	Sulfhydryl Compounds	172-177	prolyl 4-hydroxylase subunit beta	Homo sapiens	115-118
2619767-5	1989	Chemical modification data confirm the role of the thioredoxin domains in thiol:disulphide interchange activity, and structural models of these domains can be built based on homology with thioredoxin.	Sulfhydryl Compounds	74-79	thioredoxin	Homo sapiens	51-62
2619767-5	1989	Chemical modification data confirm the role of the thioredoxin domains in thiol:disulphide interchange activity, and structural models of these domains can be built based on homology with thioredoxin.	Sulfhydryl Compounds	74-79	thioredoxin	Homo sapiens	188-199
2653381-2	1989	Reduced thioredoxin was subjected to chemical modification studies employing organoarsenical reagents specific for "spatially close" thiols.	Sulfhydryl Compounds	133-139	thioredoxin	Homo sapiens	8-19
2690907-12	1989	In fact, sulphydryl (-SH) containing ACE inhibitors such as captopril appear to act as scavengers of oxygen-derived free radical species thought to be important in the pathogenesis of both postischaemic contractile dysfunction and ischaemia/reperfusion induced myocyte necrosis.	Sulfhydryl Compounds	9-19	angiotensin I converting enzyme	Homo sapiens	37-40
2663563-6	1989	Inhibition with thiol compounds was found to be a specific phenomenon of the cathepsin D from the human spleen.	Sulfhydryl Compounds	16-21	cathepsin D	Homo sapiens	77-88
2709339-2	1989	The intracellular thiol-disulfide ratio is also identical to that of mammalian tissues, due to the activity of glutathione reductase.	Sulfhydryl Compounds	18-23	glutathione-disulfide reductase	Homo sapiens	111-132
2716009-6	1989	We suggest that intrachondrocyte oxidant damage occurs through oxidation of the sensitive thiol (-SH) residue at the active center of G-3-PDH, with subsequent reduction in the rate of glycolytic ATP synthesis and the intracellular concentration of ATP which is required for DNA, protein, proteoglycan and hyaluronic acid synthesis.	Sulfhydryl Compounds	90-95	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	134-141
2562128-10	1989	The effects of all these sulfhydryl reagents suggest that the DA transporter has one or more thiol group(s) important for both binding and uptake activities.	Sulfhydryl Compounds	93-98	solute carrier family 6 member 3	Bos taurus	62-76
2852003-0	1988	Myeloperoxidase oxidation states involved in myeloperoxidase-oxidase oxidation of thiols.	Sulfhydryl Compounds	82-88	myeloperoxidase	Homo sapiens	0-15
2852003-0	1988	Myeloperoxidase oxidation states involved in myeloperoxidase-oxidase oxidation of thiols.	Sulfhydryl Compounds	82-88	myeloperoxidase	Homo sapiens	45-60
2852003-1	1988	The changes in the oxidation state of the leucocyte enzyme myeloperoxidase, induced by buffer and thiols, were studied with visible-light-absorption spectroscopy.	Sulfhydryl Compounds	98-104	myeloperoxidase	Homo sapiens	59-74
2852003-3	1988	These minute amounts of reduced oxygen species are suggested to account for the initiation of myeloperoxidase-oxidase oxidation of thiols.	Sulfhydryl Compounds	131-137	myeloperoxidase	Homo sapiens	94-109
2852003-4	1988	Myeloperoxidase was found to be in its Compound III oxidation state during myeloperoxidase-oxidase oxidation of thiols.	Sulfhydryl Compounds	112-118	myeloperoxidase	Homo sapiens	0-15
2852003-4	1988	Myeloperoxidase was found to be in its Compound III oxidation state during myeloperoxidase-oxidase oxidation of thiols.	Sulfhydryl Compounds	112-118	myeloperoxidase	Homo sapiens	75-90
2852003-5	1988	However, myeloperoxidase-mediated oxidation of thiols with concomitant O2 consumption can also occur with myeloperoxidase in its Compound II oxidation state.	Sulfhydryl Compounds	47-53	myeloperoxidase	Homo sapiens	9-24
2852003-5	1988	However, myeloperoxidase-mediated oxidation of thiols with concomitant O2 consumption can also occur with myeloperoxidase in its Compound II oxidation state.	Sulfhydryl Compounds	47-53	myeloperoxidase	Homo sapiens	106-121
2852003-6	1988	These studies indicate that the ferro and Compound III oxidation states may not be essential intermediates in myeloperoxidase-oxidase oxidation of thiols, but rather that the formation of the Compound III oxidation state retards the reaction.	Sulfhydryl Compounds	147-153	myeloperoxidase	Homo sapiens	110-125
3233215-8	1988	U.S.A. 76, 4966-4970] suggested that the two thiols cross-linked were SH1 (Cys-707) and SH2 (Cys-697) from the myosin heavy chain.	Sulfhydryl Compounds	45-51	PBV1SPCR2	Oryctolagus cuniculus	111-129
3235769-4	1988	Thymidylate synthase solutions of 0.06 mM were effectively separated from 50 mM 2-mercaptoethanol or dithiothreitol with a minimum average 5900-fold dilution of the thiol after consecutive column chromatography.	Sulfhydryl Compounds	165-170	thymidylate synthetase	Homo sapiens	0-20
2903772-3	1988	(a) The reaction of the thiol groups with dopaquinone after the tyrosinase-catalyzed oxidation of tyrosine and dopa.	Sulfhydryl Compounds	24-29	tyrosinase	Homo sapiens	64-74
2903772-6	1988	(b) The direct interaction between the sulfhydryl compounds and the tyrosinase active site.	Sulfhydryl Compounds	39-59	tyrosinase	Homo sapiens	68-78
2903772-8	1988	It is shown that Harding-Passey mouse melanoma tyrosinase is more sensitive to sulfhydryl compounds than mushroom tyrosinase.	Sulfhydryl Compounds	79-99	tyrosinase	Homo sapiens	47-57
3199797-0	1988	Modulation of myoglobin-H2O2-mediated peroxidation reactions by sulfhydryl compounds.	Sulfhydryl Compounds	64-84	myoglobin	Homo sapiens	14-23
3199797-1	1988	The ability of specific low molecular weight sulfhydryl compounds to inhibit the myoglobin-H2O2 peroxidation of uric acid and arachidonic acid was investigated.	Sulfhydryl Compounds	45-55	myoglobin	Homo sapiens	81-90
3199797-9	1988	The formation of the ferriperoxide myoglobin derivative was partially inhibited by the addition of reduced sulfhydryl compounds.	Sulfhydryl Compounds	107-117	myoglobin	Homo sapiens	35-44
3199797-11	1988	The cardioprotective effects of alpha-mercaptopropionyl glycine and other sulfhydryl-containing compounds during reperfusion injury may be attributed, at least in part, to their ability to inhibit myoglobin-H2O2-mediated peroxidation reactions.	Sulfhydryl Compounds	74-84	myoglobin	Homo sapiens	197-206
2849420-10	1988	The RBP receptor was trypsin-, heat- and thiol-group-specific-reagent sensitive and was highly specific for RBP.	Sulfhydryl Compounds	41-46	retinol binding protein 4	Homo sapiens	4-7
2851678-0	1988	Inhibition of angiotensin converting enzyme by (R)-3-[(S)-1-carboxy-5-(4-piperidyl)pentyl]amino-4-oxo-2,3,4,5-tetra- hydro-1,5-benzothiazepine-6-acetic acid (CV-5975), a non-sulfhydryl compound.	Sulfhydryl Compounds	174-184	angiotensin-converting enzyme	Oryctolagus cuniculus	14-43
3190671-3	1988	Thus caldesmon may have two calmodulin-binding sites, each containing, or being near, one of the two thiol residues.	Sulfhydryl Compounds	101-106	calmodulin 2	Gallus gallus	28-38
2849420-10	1988	The RBP receptor was trypsin-, heat- and thiol-group-specific-reagent sensitive and was highly specific for RBP.	Sulfhydryl Compounds	41-46	retinol binding protein 4	Homo sapiens	108-111
2848499-12	1988	Thus it is concluded that the inactivation of the hexokinase by 2-aminothiophenol was a consequence of a covalent disulphide bond formation between the aminothiol and thiol function at or near the active site of the enzyme.	Sulfhydryl Compounds	157-162	hexokinase	Saccharomyces cerevisiae S288C	50-60
3207681-4	1988	We have previously reported inhibition of microsomal ACAT by histidine and sulfhydryl-selective chemical modification reagents and present here a more detailed analysis of the effect of sulfhydryl modification on ACAT activity.	Sulfhydryl Compounds	75-85	sterol O-acyltransferase 1	Homo sapiens	53-57
3207681-4	1988	We have previously reported inhibition of microsomal ACAT by histidine and sulfhydryl-selective chemical modification reagents and present here a more detailed analysis of the effect of sulfhydryl modification on ACAT activity.	Sulfhydryl Compounds	186-196	sterol O-acyltransferase 1	Homo sapiens	213-217
2848499-18	1988	Inhibition of the hexokinase by heteroaromatic thiols was dependent on the nature of the heterocyclic ring and position of the thiol-thione equilibrium.	Sulfhydryl Compounds	47-53	hexokinase	Saccharomyces cerevisiae S288C	18-28
3410841-0	1988	Thiol/disulfide exchange between 3-hydroxy-3-methylglutaryl-CoA reductase and glutathione.	Sulfhydryl Compounds	0-5	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	33-73
2848577-10	1988	Finally, the solvent equilibrium isotope effect measured with yeast glutathione reductase is 4.98, which allows us to calculate a fractionation factor for the thiol moiety of GSH of 0.456.	Sulfhydryl Compounds	159-164	glutathione-disulfide reductase	Homo sapiens	68-89
3180835-1	1988	Glutathione-insulin transhydrogenase (GIT, thiol:protein-disulfide isomerase/oxidoreductase, E.C.	Sulfhydryl Compounds	43-48	insulin	Bos taurus	12-19
3419426-3	1988	An investigation into the structure-activity relationship using a variety of different dithiols demonstrated that the ability of the dithiols to protect against and to reverse the inhibition of glucokinase by alloxan was dependent on the spacing between the SH (thiol) groups of the various dithiols.	Sulfhydryl Compounds	89-94	glucokinase	Homo sapiens	194-205
2457025-9	1988	Cytochrome c reduction was not inhibited by several mitochondrial respiratory chain inhibitors (azide, cyanide, and rotenone) but was sensitive to thiol-reactive agents (p-chloromercuribenzoate and monoiodo acetate).	Sulfhydryl Compounds	147-152	cytochrome c, somatic	Homo sapiens	0-12
2851562-0	1988	Synthesis and receptor binding characteristics of [D-Ala2, cysteamine 5] enkephalin, a thiol-containing probe for structural elements of opiate receptors.	Sulfhydryl Compounds	87-92	proenkephalin	Rattus norvegicus	73-83
3179268-4	1988	Evidence presented here shows that oncomodulin can dimerize by intermolecular disulfide formation via the Cys-18 thiol.	Sulfhydryl Compounds	113-118	oncomodulin	Homo sapiens	35-46
3421939-3	1988	When filaggrin was labelled in vivo with [3H]histidine and then incubated with rat epidermal preparations, the label was rendered SDS/thiol-insoluble.	Sulfhydryl Compounds	134-139	filaggrin	Rattus norvegicus	5-14
3219359-9	1988	Fluorescence labeling of thrombin required reaction of the inhibitor at the active site as well as subsequent generation of the thiol group with NH2OH.	Sulfhydryl Compounds	128-133	coagulation factor II, thrombin	Homo sapiens	25-33
2851562-1	1988	For the elucidation of structural elements in the opiate receptors, a thiol-containing enkephalin analog [D-Ala2, cysteamine 5]enkephalin, and its dimeric analog were synthesized and evaluated in the radio-ligand receptor binding assays using rat brain membranes.	Sulfhydryl Compounds	70-75	proenkephalin	Rattus norvegicus	87-97
2851562-1	1988	For the elucidation of structural elements in the opiate receptors, a thiol-containing enkephalin analog [D-Ala2, cysteamine 5]enkephalin, and its dimeric analog were synthesized and evaluated in the radio-ligand receptor binding assays using rat brain membranes.	Sulfhydryl Compounds	70-75	proenkephalin	Rattus norvegicus	127-137
2851562-3	1988	Comparison of receptor affinities of the thiol-containing enkephalin with those of standard mu or delta receptor specific ligands suggested that the mu receptor contains an essential thiol group which may interact with the thiol group at the C-terminus of the enkephalin analog.	Sulfhydryl Compounds	41-46	proenkephalin	Rattus norvegicus	58-68
2898532-4	1988	Although analysis of cis-1 with 2,2"-dithiobis(5-nitrobenzoic acid) revealed significant loss of the free thiol group under enzymatic assay conditions, the addition of the reducing agent, dithiothreitol, to the enzymatic reaction mixtures afforded cis-1 complete protection against this chemical decomposition, as evidenced by lowering of the inhibition constant in the presence of dithiothreitol.	Sulfhydryl Compounds	106-111	suppressor of cytokine signaling 1	Homo sapiens	21-26
2851562-3	1988	Comparison of receptor affinities of the thiol-containing enkephalin with those of standard mu or delta receptor specific ligands suggested that the mu receptor contains an essential thiol group which may interact with the thiol group at the C-terminus of the enkephalin analog.	Sulfhydryl Compounds	41-46	proenkephalin	Rattus norvegicus	260-270
2898532-4	1988	Although analysis of cis-1 with 2,2"-dithiobis(5-nitrobenzoic acid) revealed significant loss of the free thiol group under enzymatic assay conditions, the addition of the reducing agent, dithiothreitol, to the enzymatic reaction mixtures afforded cis-1 complete protection against this chemical decomposition, as evidenced by lowering of the inhibition constant in the presence of dithiothreitol.	Sulfhydryl Compounds	106-111	suppressor of cytokine signaling 1	Homo sapiens	248-253
2851562-3	1988	Comparison of receptor affinities of the thiol-containing enkephalin with those of standard mu or delta receptor specific ligands suggested that the mu receptor contains an essential thiol group which may interact with the thiol group at the C-terminus of the enkephalin analog.	Sulfhydryl Compounds	183-188	proenkephalin	Rattus norvegicus	58-68
2851562-3	1988	Comparison of receptor affinities of the thiol-containing enkephalin with those of standard mu or delta receptor specific ligands suggested that the mu receptor contains an essential thiol group which may interact with the thiol group at the C-terminus of the enkephalin analog.	Sulfhydryl Compounds	183-188	proenkephalin	Rattus norvegicus	260-270
2851562-3	1988	Comparison of receptor affinities of the thiol-containing enkephalin with those of standard mu or delta receptor specific ligands suggested that the mu receptor contains an essential thiol group which may interact with the thiol group at the C-terminus of the enkephalin analog.	Sulfhydryl Compounds	183-188	proenkephalin	Rattus norvegicus	58-68
2851562-3	1988	Comparison of receptor affinities of the thiol-containing enkephalin with those of standard mu or delta receptor specific ligands suggested that the mu receptor contains an essential thiol group which may interact with the thiol group at the C-terminus of the enkephalin analog.	Sulfhydryl Compounds	183-188	proenkephalin	Rattus norvegicus	260-270
3185539-2	1988	It was found that the strongest complex of thiol with P450 is formed for n = 3.	Sulfhydryl Compounds	43-48	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	54-58
3185539-5	1988	The interaction of this thiol (n = 3) with both the heme group of P450 and the hydrophobic substrate zone is supposed and the distance between these points was estimated.	Sulfhydryl Compounds	24-29	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	66-70
3130895-4	1988	Calmodulin antagonists inhibited protein thiol loss induced by either of the compound, inhibited cell aggregation and prolonged cell viability, but did not influence NADH loss.	Sulfhydryl Compounds	41-46	calmodulin 1	Rattus norvegicus	0-10
3130895-6	1988	Therefore, the inhibition of protein thiol loss by calmodulin antagonist may be due to a dissociation of calmodulin-binding proteins from cytoskeletal elements.	Sulfhydryl Compounds	37-42	calmodulin 1	Rattus norvegicus	51-61
3139025-7	1988	The Drosophila IDE activity, like the mammalian enzymes, is inhibited by bacitracin and sulfhydryl-specific reagents.	Sulfhydryl Compounds	88-98	Insulin degrading metalloproteinase	Drosophila melanogaster	15-18
3130895-6	1988	Therefore, the inhibition of protein thiol loss by calmodulin antagonist may be due to a dissociation of calmodulin-binding proteins from cytoskeletal elements.	Sulfhydryl Compounds	37-42	calmodulin 1	Rattus norvegicus	105-115
3163236-3	1988	Grinding intestine under liquid nitrogen and placing the powder in phosphate buffer (pH 7.0) containing thiol reductants and protease inhibitors adequately preserved total XDH + XO activity and the percentage in the oxidase form (%XO) for 24 h. Total activity in nonischemic intestine ranged from 374 nmol.min-1.g-1 in duodenum to 138 nmol.min-1.g-1 in ileum, while XO activity was approximately 19% of total activity throughout the entire small intestine.	Sulfhydryl Compounds	104-109	xanthine dehydrogenase	Rattus norvegicus	172-175
3052455-8	1988	These results suggest that the native RnBP exists as a dimeric form and dissociates to a monomeric form by sulfhydryl-alkylating or -oxidizing reagent.	Sulfhydryl Compounds	107-117	renin binding protein	Homo sapiens	38-42
3131437-3	1988	The antibody was first azo-coupled with DPEM to introduce the maleimide groups into the molecule; excess reagent was removed by gel filtration and then the activated antibodies were crosslinked to the thiol groups of Gal.	Sulfhydryl Compounds	201-206	galanin and GMAP prepropeptide	Homo sapiens	217-220
2452603-1	1988	Reaction of equine alpha 2-macroglobulin (alpha 2M) with methylamine caused generation of 3.7 mol of thiol groups per mole of the protein, and the second-order rate constant of the generation was calculated to be 3.5 M-1 s-1.	Sulfhydryl Compounds	101-106	alpha-2-macroglobulin	Equus caballus	19-40
2452603-1	1988	Reaction of equine alpha 2-macroglobulin (alpha 2M) with methylamine caused generation of 3.7 mol of thiol groups per mole of the protein, and the second-order rate constant of the generation was calculated to be 3.5 M-1 s-1.	Sulfhydryl Compounds	101-106	alpha-2-macroglobulin	Equus caballus	42-50
2836111-3	1988	Three chemical classes of angiotensin converting-enzyme inhibitors have been introduced into clinical use, the sulfhydryl-containing inhibitors such as captopril and its analogs and prodrugs, carboxyalkyldipeptides such as enalapril and its analogs, and phosphorus-containing inhibitors such as fosinopril and the phosphonate SQ 29,852.	Sulfhydryl Compounds	111-121	angiotensin I converting enzyme	Homo sapiens	26-55
2839099-6	1988	In vitro experiments show that at a molar ratio cis-DDP:JM-8 1:10, the two compounds bind to low MW thiols with the same kinetics.	Sulfhydryl Compounds	100-106	translocase of inner mitochondrial membrane 8A	Homo sapiens	52-55
3182746-0	1988	Human serum biotinidase is a thiol-type enzyme.	Sulfhydryl Compounds	29-34	biotinidase	Homo sapiens	12-23
3144290-2	1988	The intra- and interchain thiol-disulfide exchange reactions accompanying the denaturation of cathepsin B were investigated by polyacrylamide gel electrophoresis in SDS and by gel filtration experiments.	Sulfhydryl Compounds	26-31	cathepsin B	Bos taurus	94-105
3144290-4	1988	After conditions preventing thiol-disulfide exchange reactions, had been developed, the second SH-group (Cys240) was demonstrated independently in carboxymethylated cathepsin B by labeling with 4-(dimethylamino)azobenzene-4"-iodoacetamide and by selective isolation of the SH-peptide containing Cys240 on thiopropyl-Sepharose.	Sulfhydryl Compounds	28-33	cathepsin B	Bos taurus	165-176
3401446-3	1988	Zn2+ binding to high-affinity sites of native S100b protected the sulfhydryl groups against the thiol-specific reagent 5,5"-dithiobis(2-nitrobenzoate) and antagonized the Ca2+-stimulated reactivity of Cys-84 beta toward the reagent.	Sulfhydryl Compounds	96-101	S100 calcium binding protein B	Bos taurus	46-51
2831100-3	1988	A maleimide spin label was selectively attached to the free thiol group presumably near the carboxyl-terminal domain in which Ca2+-binding sites are situated.	Sulfhydryl Compounds	60-65	carbonic anhydrase 2	Homo sapiens	126-129
3128179-8	1988	When water attacks C-4, the 2-carbamoyl group can eliminate to form a Michael-like acceptor which adds thiols at the 2-methylene position.	Sulfhydryl Compounds	103-109	complement C4A (Rodgers blood group)	Homo sapiens	19-22
2895925-0	1988	On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.	Sulfhydryl Compounds	19-24	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	28-61
2843563-13	1988	This is deduced from the following findings: (i) the addition of dithiothreitol after trinitrophenylation partially reversed the loss in the K+(EDTA)-ATPase activity; and (ii) the specific alkylation of the SH1 thiol by 1,5-IAEDANS prior to trinitrophenylation prevented the effect of dithiothreitol on the ATPase activity of myosin.	Sulfhydryl Compounds	211-216	myosin heavy chain 14	Homo sapiens	326-332
3350146-1	1988	Covalent coupling of bovine rhodopsin to CPG-thiol glass was used for separation of CNBr peptides.	Sulfhydryl Compounds	45-50	rhodopsin	Bos taurus	28-37
3345513-4	1988	Cell surface CB activity required thiol activation and was blocked by the CB-selective protease inhibitors leupeptin, antipain, and L-trans-epoxysuccinylleucylamido(4-guanidino)butane, but not by inhibitors inactive against CB.	Sulfhydryl Compounds	34-39	cathepsin B	Mus musculus	13-15
2963863-7	1988	This specificity of binding and the ability to rebind to a second column of iC3- or C3b-thiol-Sepharose are comparable to human CR1.	Sulfhydryl Compounds	88-93	endogenous retrovirus group K member 3	Homo sapiens	84-87
2454317-1	1988	We have measured the rotational motion of myosin heads in synthetic thick filaments at 4 degrees C in the time range from 10(-7) to 10(-4) seconds, by measuring transient absorption anisotropy of an eosin probe attached to a reactive sulfhydryl on the myosin head.	Sulfhydryl Compounds	234-244	myosin heavy chain 14	Homo sapiens	42-48
2851201-0	1988	4-Hydroxyestradiol is conjugated with thiols primarily at C-2: evidence from regiospecific displacement of tritium by rat liver microsomes or tyrosinase.	Sulfhydryl Compounds	38-44	complement C2	Rattus norvegicus	58-61
2851201-0	1988	4-Hydroxyestradiol is conjugated with thiols primarily at C-2: evidence from regiospecific displacement of tritium by rat liver microsomes or tyrosinase.	Sulfhydryl Compounds	38-44	tyrosinase	Rattus norvegicus	142-152
3365394-2	1988	The reduced and carboxymethylated apolipoprotein B was incubated with 50 mM [14C]methylamine at pH 8.5 at 30 degrees C. Covalent incorporation of [14C]methylamine was observed with concomitant generation of new sulfhydryl groups, which could be blocked with [3H]- or [14C]iodoacetic acid.	Sulfhydryl Compounds	211-221	apolipoprotein B	Homo sapiens	34-50
3162724-9	1988	The xanthine dehydrogenase----xanthine oxidase conversion thus appears to be sensitive to the redox state of thiol groups.	Sulfhydryl Compounds	109-114	xanthine dehydrogenase	Rattus norvegicus	4-26
3355522-0	1988	Rat liver cytosol contains NADPH- and GSH-dependent factors able to restore ornithine decarboxylase inactivated by removal of thiol reducing agents.	Sulfhydryl Compounds	126-131	ornithine decarboxylase 1	Rattus norvegicus	76-99
3355522-8	1988	These results suggest the existence of reducing systems in the cytosol, which may play a role in maintaining, and potentially in regulating, ODC activity by modulation of its thiol status.	Sulfhydryl Compounds	175-180	ornithine decarboxylase 1	Rattus norvegicus	141-144
3367699-3	1988	This Cu2+-dependent inhibition of acid cholesterol ester hydrolase (CEH) activity was completely prevented by ethylenediamine tetraacetic acid (EDTA), EGTA and o-phenanthroline, a chelator with a stability constant for Cu2+, and also by sulfhydryl agents and cytoplasmic reducing agents such as cysteine, glutathione and mercaptoethanol.	Sulfhydryl Compounds	237-247	epoxide hydrolase 2	Rattus norvegicus	39-66
3367699-3	1988	This Cu2+-dependent inhibition of acid cholesterol ester hydrolase (CEH) activity was completely prevented by ethylenediamine tetraacetic acid (EDTA), EGTA and o-phenanthroline, a chelator with a stability constant for Cu2+, and also by sulfhydryl agents and cytoplasmic reducing agents such as cysteine, glutathione and mercaptoethanol.	Sulfhydryl Compounds	237-247	epoxide hydrolase 2	Rattus norvegicus	68-71
2826432-1	1988	Phosphoribulokinase is light-regulated via thioredoxin by reversible oxidation/reduction of sulfhydryl/disulfide groups.	Sulfhydryl Compounds	92-102	thioredoxin	Homo sapiens	43-54
3345734-0	1988	Effect of some thiol reagents on erythrocyte adenosine deaminase (ADA) activity.	Sulfhydryl Compounds	15-20	adenosine deaminase	Homo sapiens	66-69
3345734-1	1988	The effect of three thiol reagents on erythrocyte adenosine deaminase (ADA) activity has been studied.	Sulfhydryl Compounds	20-25	adenosine deaminase	Homo sapiens	71-74
2450578-4	1988	Incubation of alpha 2M or cis-DDP-treated alpha 2M with trypsin results in complete subunit cleavage; however, trypsin treatment of cis-DDP-alpha 2M does not result in a conformational change as determined by nondenaturing polyacrylamide gel electrophoresis (PAGE), receptor recognition site exposure, or appearance of thiol groups from the inhibitor.	Sulfhydryl Compounds	319-324	alpha-2-macroglobulin	Homo sapiens	42-50
2450578-4	1988	Incubation of alpha 2M or cis-DDP-treated alpha 2M with trypsin results in complete subunit cleavage; however, trypsin treatment of cis-DDP-alpha 2M does not result in a conformational change as determined by nondenaturing polyacrylamide gel electrophoresis (PAGE), receptor recognition site exposure, or appearance of thiol groups from the inhibitor.	Sulfhydryl Compounds	319-324	alpha-2-macroglobulin	Homo sapiens	42-50
2450578-8	1988	Complete receptor recognition site exposure and the appearance of 3.3 thiol groups/mol of alpha 2M also occur following this treatment.	Sulfhydryl Compounds	70-75	alpha-2-macroglobulin	Homo sapiens	90-98
3255237-0	1988	Phosphorylation by casein kinase-2 and reversible alteration of thiol groups: mechanisms of control of ornithine decarboxylase?	Sulfhydryl Compounds	64-69	ornithine decarboxylase 1	Homo sapiens	103-126
3386251-4	1988	Pretreatment of immunoadsorbed receptor complexes with the thiol derivatizing agent, methyl methanethiosulfonate (MMTS) prevents the ability of H2O2 to stabilize the hsp90-receptor interaction.	Sulfhydryl Compounds	59-64	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	166-171
3121676-11	1988	These results suggest that the presence of certain thiol reducing agents, divalent cations and negatively charged B6 vitamers can alter the conformation of the mutant alpha-L-iduronidase in vitro such that the hydrolysis of 4MU-alpha-Id is enhanced into the heterozygote range.	Sulfhydryl Compounds	51-56	alpha-L-iduronidase	Homo sapiens	167-186
2978620-7	1988	Purification of ADF protein and the cDNA cloning proved that ADF is closely related to the autocrine growth factor produced by an EBV(+) B cell line 3B6 (H. Wakasugi and T. Tursz) and belonging to the family of thiol reducing co-enzyme thioredoxin which is involved in many biological reactions.	Sulfhydryl Compounds	211-216	thioredoxin	Homo sapiens	61-64
2450410-2	1988	This binding leads to quantitative cleavage of the bait region of the inhibitor and to release of 3.6 thiol groups per molecule of alpha 2M, reflecting cleavage of the thioester bonds.	Sulfhydryl Compounds	102-107	alpha-2-macroglobulin	Homo sapiens	131-139
2833080-4	1987	These results indicate that the sulphydryl compounds work as scavengers of the products of the Myeloperoxidase system, and might be useful in inflammatory disorders, to prevent tissue damage inflicted by this system.	Sulfhydryl Compounds	32-42	myeloperoxidase	Homo sapiens	95-110
20837438-3	1988	Subsequent hydrolysis by gamma-glutamyltranspeptidase (GGT) leads to the cysteine conjugate S- (pentachlorobutadienyl)- l -cysteine (PCBC), which is cleaved by cysteine conjugate beta-lyase to pyruvate, ammonia and a reactive thiol, which is presumed to induce nephrotoxicity and nephrocarcinogenicity.	Sulfhydryl Compounds	226-231	gamma-glutamyltransferase 1	Rattus norvegicus	25-53
20837438-3	1988	Subsequent hydrolysis by gamma-glutamyltranspeptidase (GGT) leads to the cysteine conjugate S- (pentachlorobutadienyl)- l -cysteine (PCBC), which is cleaved by cysteine conjugate beta-lyase to pyruvate, ammonia and a reactive thiol, which is presumed to induce nephrotoxicity and nephrocarcinogenicity.	Sulfhydryl Compounds	226-231	gamma-glutamyltransferase 1	Rattus norvegicus	55-58
3680289-4	1987	Maximal activity of HMG-CoA reductase induced by RAP is comparable to that obtained in the presence of thiols, such as GSH, and can exceed 100-fold the activity obtained when thiols are omitted.	Sulfhydryl Compounds	103-109	LDL receptor related protein associated protein 1	Rattus norvegicus	49-52
3680289-4	1987	Maximal activity of HMG-CoA reductase induced by RAP is comparable to that obtained in the presence of thiols, such as GSH, and can exceed 100-fold the activity obtained when thiols are omitted.	Sulfhydryl Compounds	175-181	LDL receptor related protein associated protein 1	Rattus norvegicus	49-52
3449208-8	1987	They also indicate that disulfiram represents a sensitive reagent to characterize the thiol requirement of the 5-lipoxygenase reaction.	Sulfhydryl Compounds	86-91	arachidonate 5-lipoxygenase	Rattus norvegicus	111-125
3426230-1	1987	This study characterizes the structural and functional significance of sulfhydryl residues in human plasma heparin cofactor II (HCII).	Sulfhydryl Compounds	71-81	serpin family D member 1	Homo sapiens	107-126
3426230-1	1987	This study characterizes the structural and functional significance of sulfhydryl residues in human plasma heparin cofactor II (HCII).	Sulfhydryl Compounds	71-81	serpin family D member 1	Homo sapiens	128-132
3426230-6	1987	Treatment with various sulfhydryl-specific reagents, including p-mercuribenzoate, HgCl2, and N-substituted maleimide derivatives, inactivated HCII.	Sulfhydryl Compounds	23-33	serpin family D member 1	Homo sapiens	142-146
2832248-1	1987	Orientation dependence and rotational motion of maleimide spin labels attached to the fast reacting thiol sites of myosin were studied in glycerinated cardiac and skeletal muscle fibres in rigor and in relaxing medium.	Sulfhydryl Compounds	100-105	spindlin 1	Homo sapiens	58-62
3436051-0	1987	Low molecular weight thiol content in glutathione synthetase-deficient human fibroblasts.	Sulfhydryl Compounds	21-26	glutathione synthetase	Homo sapiens	38-60
2832248-1	1987	Orientation dependence and rotational motion of maleimide spin labels attached to the fast reacting thiol sites of myosin were studied in glycerinated cardiac and skeletal muscle fibres in rigor and in relaxing medium.	Sulfhydryl Compounds	100-105	myosin heavy chain 14	Homo sapiens	115-121
3437026-3	1987	The thiol compounds in plasma, which are reduced or liberated from plasma proteins with tri-n-butylphosphine, are derivatized with a thiol-specific fluorogenic reagent, ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate.	Sulfhydryl Compounds	133-138	OXA1L mitochondrial inner membrane protein	Homo sapiens	194-199
3118957-10	1987	The effect of phenylglyoxal on aldose reductase may be explained by the modification of a reactive thiol or lysine rather than an arginine residue.	Sulfhydryl Compounds	99-104	aldo-keto reductase family 1 member B	Homo sapiens	31-47
3437026-3	1987	The thiol compounds in plasma, which are reduced or liberated from plasma proteins with tri-n-butylphosphine, are derivatized with a thiol-specific fluorogenic reagent, ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate.	Sulfhydryl Compounds	4-9	OXA1L mitochondrial inner membrane protein	Homo sapiens	194-199
3316203-12	1987	Activated thiol beads bound one-half as much sickle protein 4.1 as normal protein 4.1 when both were solubilized directly from membranes, demonstrating that thiol oxidation had occurred in vivo.	Sulfhydryl Compounds	10-15	erythrocyte membrane protein band 4.1	Homo sapiens	52-63
2827750-7	1987	The presence of sulfur----cobalt charge-transfer bands in both the visible absorption and magnetic circular dichroic spectra of the cobalt ACE-Captopril complex confirm direct ligation of the thiol group of the inhibitor to the active-site metal.	Sulfhydryl Compounds	192-197	angiotensin I converting enzyme	Homo sapiens	139-142
2826190-0	1987	Modification of the peripheral-type benzodiazepine receptor by arachidonate, diethylpyrocarbonate and thiol reagents.	Sulfhydryl Compounds	102-107	translocator protein	Rattus norvegicus	20-59
3500140-7	1987	There is evidence also from literature data for a correlation between oxygen enhancement and RSS.-R stability, which varies with thiol concentration, pH and thiol structure.	Sulfhydryl Compounds	129-134	Russell-Silver dwarfism	Homo sapiens	93-96
3500140-7	1987	There is evidence also from literature data for a correlation between oxygen enhancement and RSS.-R stability, which varies with thiol concentration, pH and thiol structure.	Sulfhydryl Compounds	157-162	Russell-Silver dwarfism	Homo sapiens	93-96
2835061-6	1987	These are thiol-containing proteases which will also release ubiquitin from ubiquitin-protein conjugates.	Sulfhydryl Compounds	10-15	ubiquitin	Bos taurus	61-70
2892525-1	1987	A new family of asymmetric thiol-disulfide exchange reagents, the dinitrophenyl alkyl disulfides (DNPSSR), was used to modify rat liver phenylalanine hydroxylase.	Sulfhydryl Compounds	27-32	phenylalanine hydroxylase	Rattus norvegicus	136-161
2446045-8	1987	The fourth antibody, Mu-1, appeared to react with a conformational determinant since its epitope was destroyed by heat treatment or thiol reduction.	Sulfhydryl Compounds	132-137	glutathione S-transferase mu 1	Homo sapiens	21-25
3675570-0	1987	Reversible oxidation of glyceraldehyde 3-phosphate dehydrogenase thiols in human lung carcinoma cells by hydrogen peroxide.	Sulfhydryl Compounds	65-71	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	24-64
3675570-6	1987	Glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) has been identified as the protein undergoing thiol/disulfide redox status and enzymic activity changes.	Sulfhydryl Compounds	101-106	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
2835061-6	1987	These are thiol-containing proteases which will also release ubiquitin from ubiquitin-protein conjugates.	Sulfhydryl Compounds	10-15	ubiquitin	Bos taurus	76-85
16665718-4	1987	The results show that, since thioredoxin h does not react effectively with fructose-1,6-bisphosphatase, the thioredoxin system can activate an enzyme through purothionin by secondary thiol redox control.	Sulfhydryl Compounds	183-188	thioredoxin H4-2	Triticum aestivum	29-40
3668849-1	1987	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of 6-mercaptopurine and other heterocyclic and aromatic thiol compounds.	Sulfhydryl Compounds	120-125	thiopurine methyltransferase	Mus musculus	0-28
3668849-1	1987	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of 6-mercaptopurine and other heterocyclic and aromatic thiol compounds.	Sulfhydryl Compounds	120-125	thiopurine methyltransferase	Mus musculus	30-34
2959956-6	1987	From these and earlier results, we propose a possible mechanism in which the carbon-centered radical formed at C-5" by hydrogen atom abstraction by thiol-activated NCS-Chrom reacts anaerobically with misonidazole to form a nitroxyl-radical-adduct intermediate, which fragments to produce an oxy radical at C-5".	Sulfhydryl Compounds	148-153	complement C5	Homo sapiens	111-114
2959956-6	1987	From these and earlier results, we propose a possible mechanism in which the carbon-centered radical formed at C-5" by hydrogen atom abstraction by thiol-activated NCS-Chrom reacts anaerobically with misonidazole to form a nitroxyl-radical-adduct intermediate, which fragments to produce an oxy radical at C-5".	Sulfhydryl Compounds	148-153	complement C5	Homo sapiens	306-309
16665718-4	1987	The results show that, since thioredoxin h does not react effectively with fructose-1,6-bisphosphatase, the thioredoxin system can activate an enzyme through purothionin by secondary thiol redox control.	Sulfhydryl Compounds	183-188	thioredoxin H4-2	Triticum aestivum	108-119
3115973-13	1987	There is one potential free sulfhydryl in human cholinesterase at Cys66, but this sulfhydryl could not be alkylated.	Sulfhydryl Compounds	28-38	butyrylcholinesterase	Homo sapiens	48-62
2822039-2	1987	These three ANF receptor subtypes include; (1) a disulfide-linked 140 kDa protein found in RTASM cells which was reduced by sulfhydryl reagent dithiothreitol (DTT) to a 70 kDa band, (2) a disulfide-unlinked 120 kDa protein, specific to MDCK cells whose Mr was not reduced by DTT and (3) a 68-70 kDa protein prevalent in both RTASM and MDCK cells whose Mr was not reduced by DTT.	Sulfhydryl Compounds	124-134	natriuretic peptide A	Canis lupus familiaris	12-15
2445377-4	1987	Interaction of factor Xa with alpha 2M resulted in the appearance of four thiol groups per molecule of alpha 2M.	Sulfhydryl Compounds	74-79	coagulation factor X	Homo sapiens	15-24
3115266-3	1987	Incubations in the buffer with detergent, however, resulted in the limited proteolysis of MP26 which was totally inhibited by calcium chelators, thiol-alkylating agents, and protease inhibitors.	Sulfhydryl Compounds	145-150	major intrinsic protein of lens fiber	Homo sapiens	90-94
2445377-4	1987	Interaction of factor Xa with alpha 2M resulted in the appearance of four thiol groups per molecule of alpha 2M.	Sulfhydryl Compounds	74-79	alpha-2-macroglobulin	Homo sapiens	30-38
2445377-4	1987	Interaction of factor Xa with alpha 2M resulted in the appearance of four thiol groups per molecule of alpha 2M.	Sulfhydryl Compounds	74-79	alpha-2-macroglobulin	Homo sapiens	103-111
2445377-5	1987	The apparent second-order rate constants for the appearance of thiol groups were dependent on the factor Xa concentration.	Sulfhydryl Compounds	63-68	coagulation factor X	Homo sapiens	98-107
3115179-1	1987	Recombinant human interleukin-2 (rIL-2) produced in Escherichia coli possesses a free thiol group at Cys-125 and a disulfide linkage between Cys-58 and Cys-105, as in the case for natural human interleukin-2.	Sulfhydryl Compounds	86-91	interleukin 2	Homo sapiens	18-31
3115179-1	1987	Recombinant human interleukin-2 (rIL-2) produced in Escherichia coli possesses a free thiol group at Cys-125 and a disulfide linkage between Cys-58 and Cys-105, as in the case for natural human interleukin-2.	Sulfhydryl Compounds	86-91	interleukin 2	Rattus norvegicus	33-38
2886057-8	1987	The biliary excretion of GS-related thiols was less responsive to acivicin in 2- and 7- to 10-wk-old rats, suggesting that GGT plays a smaller role in influencing biliary thiol composition at those ages.	Sulfhydryl Compounds	36-42	gamma-glutamyltransferase 1	Rattus norvegicus	123-126
3112148-0	1987	Modulation of alveolar macrophage-derived 5-lipoxygenase products by the sulfhydryl reactant, N-ethylmaleimide.	Sulfhydryl Compounds	73-83	arachidonate 5-lipoxygenase	Rattus norvegicus	42-56
2822020-0	1987	Differential sensitivity of the insulin-receptor kinase to thiol and oxidizing agents in the absence and presence of insulin.	Sulfhydryl Compounds	59-64	insulin	Homo sapiens	32-39
2822020-0	1987	Differential sensitivity of the insulin-receptor kinase to thiol and oxidizing agents in the absence and presence of insulin.	Sulfhydryl Compounds	59-64	insulin	Homo sapiens	117-124
2822020-1	1987	The purified human placental insulin-receptor beta-subunit autophosphorylating activity was found to be inhibited, in a time- and concentration-dependent manner, by the specific thiol-alkylating agents N-ethylmaleimide and 5,5"-dithiobis-(2-nitrobenzoic acid).	Sulfhydryl Compounds	178-183	insulin	Homo sapiens	29-36
2822020-8	1987	These results indicate that there is a critical thiol group(s) necessary for the beta-subunit autophosphorylating activity of the insulin-receptor kinase and that in the presence of insulin is more susceptible to exogenously added thiol and oxidizing agents.	Sulfhydryl Compounds	48-53	insulin	Homo sapiens	130-137
2822020-8	1987	These results indicate that there is a critical thiol group(s) necessary for the beta-subunit autophosphorylating activity of the insulin-receptor kinase and that in the presence of insulin is more susceptible to exogenously added thiol and oxidizing agents.	Sulfhydryl Compounds	48-53	insulin	Homo sapiens	182-189
2822020-8	1987	These results indicate that there is a critical thiol group(s) necessary for the beta-subunit autophosphorylating activity of the insulin-receptor kinase and that in the presence of insulin is more susceptible to exogenously added thiol and oxidizing agents.	Sulfhydryl Compounds	231-236	insulin	Homo sapiens	130-137
2822020-8	1987	These results indicate that there is a critical thiol group(s) necessary for the beta-subunit autophosphorylating activity of the insulin-receptor kinase and that in the presence of insulin is more susceptible to exogenously added thiol and oxidizing agents.	Sulfhydryl Compounds	231-236	insulin	Homo sapiens	182-189
2885328-10	1987	It is proposed that S-28 processing involves a divalent cation-sensitive endoprotease that is sensitive to thiol reagents, which cleaves before the Arg-Lys doublet, which is not trypsin-like, and whose action is coupled to an aminopeptidase B-like enzyme.	Sulfhydryl Compounds	107-112	arginyl aminopeptidase	Rattus norvegicus	226-242
3501725-0	1987	Epidermal growth factor (EGF) affects sulphydryl and disulphide levels in cultured mouse skin: possible relationship between effects of EGF and of the tabby gene on thiols.	Sulfhydryl Compounds	165-171	epidermal growth factor	Mus musculus	25-28
3606128-2	1987	The data indicate that ferredoxin-thioredoxin reductase (FTR)--an iron-sulfur enzyme present in oxygenic photosynthetic organisms--is the first member of a thiol chain that links light to enzyme regulation.	Sulfhydryl Compounds	156-161	thioredoxin	Homo sapiens	34-45
3501725-0	1987	Epidermal growth factor (EGF) affects sulphydryl and disulphide levels in cultured mouse skin: possible relationship between effects of EGF and of the tabby gene on thiols.	Sulfhydryl Compounds	38-48	epidermal growth factor	Mus musculus	0-23
3501725-4	1987	In the present study we examined whether EGF affects SH and SS levels in normal mouse skin in tissue culture, and we report here that it does.	Sulfhydryl Compounds	53-55	epidermal growth factor	Mus musculus	41-44
3501725-0	1987	Epidermal growth factor (EGF) affects sulphydryl and disulphide levels in cultured mouse skin: possible relationship between effects of EGF and of the tabby gene on thiols.	Sulfhydryl Compounds	38-48	epidermal growth factor	Mus musculus	25-28
3501725-0	1987	Epidermal growth factor (EGF) affects sulphydryl and disulphide levels in cultured mouse skin: possible relationship between effects of EGF and of the tabby gene on thiols.	Sulfhydryl Compounds	165-171	epidermal growth factor	Mus musculus	0-23
3304342-4	1987	By subsequent reaction of the thiol group with N alpha-maleoyl-beta-alanyl-human-little-gastrin-I-[2-17] a fluorogenic substrate-labeled gastrin, fully immunoreactive against antigastrin antisera, was obtained.	Sulfhydryl Compounds	30-35	gastrin	Homo sapiens	88-95
3304342-4	1987	By subsequent reaction of the thiol group with N alpha-maleoyl-beta-alanyl-human-little-gastrin-I-[2-17] a fluorogenic substrate-labeled gastrin, fully immunoreactive against antigastrin antisera, was obtained.	Sulfhydryl Compounds	30-35	gastrin	Homo sapiens	137-144
3501725-7	1987	EGF at 25 ng/mL also lowers total SH + SS concentrations in the epidermal layers.	Sulfhydryl Compounds	34-36	epidermal growth factor	Mus musculus	0-3
3501725-9	1987	These data, taken together with some of our previous findings, suggest the possibility that a relationship may exist between Ta, EGF, and thiol concentrations.	Sulfhydryl Compounds	138-143	epidermal growth factor	Mus musculus	129-132
3111463-2	1987	A thiol-zinc interaction at the active site is postulated for AP-B.	Sulfhydryl Compounds	2-7	arginyl aminopeptidase	Homo sapiens	62-66
3036815-0	1987	Selective thiol group modification renders fructose-1,6-bisphosphatase insensitive to fructose 2,6-bisphosphate inhibition.	Sulfhydryl Compounds	10-15	fructose-bisphosphatase 1	Sus scrofa	43-70
3595616-1	1987	Partially purified ornithine decarboxylase, isolated from the liver of thioacetamide-treated rats, is stable in the absence of added low-molecular-mass thiols or other reducing agents.	Sulfhydryl Compounds	152-158	ornithine decarboxylase 1	Rattus norvegicus	19-42
3684968-2	1987	DPP I was assayed with SerTyrNA as substrate and showed the characteristics of a thiol-dependent serine enzyme with optimum at pH 4.5 and a molecular weight of 210,000.	Sulfhydryl Compounds	81-86	cathepsin C	Homo sapiens	0-5
3684968-3	1987	DPP II, analysed with LysAlaNA as substrate, had an optimum at pH 5.5 and a molecular weight of 130,000 with no dependence on thiol groups or divalent ions.	Sulfhydryl Compounds	126-131	dipeptidyl peptidase 7	Homo sapiens	0-6
3647875-0	1987	Isolation of a thiol-activated T-kininogenase from the rat submandibular gland.	Sulfhydryl Compounds	15-20	kallikrein 1-related peptidase C10	Rattus norvegicus	31-45
2884009-1	1987	Intracellular thiols (LSH), superoxide dismutase (SOD) and plasma thiols (PSH) are thought to have an important role in the protection of tissues from damage by oxygen-derived free radicals.	Sulfhydryl Compounds	14-20	helicase, lymphoid specific	Homo sapiens	22-25
3590192-7	1987	The activation and/or inhibition of PBG-S and associate pH-activity profile changes resulting from interaction with the four metal ions tested were attributed to their respective affinity for the thiol and other groups at the active sites.	Sulfhydryl Compounds	196-201	aminolevulinate dehydratase	Homo sapiens	36-41
3584120-12	1987	Thus, the ability of caldesmon to undergo reversible sulfhydryl cross-linking, and thereby reversible F-actin cross-linking, may be of physiological significance.	Sulfhydryl Compounds	53-63	caldesmon 1	Gallus gallus	21-30
3571267-12	1987	Together these observations indicate that rat pineal hydroxyindole-O-methyltransferase can be inactivated by a protein thiol:disulfide exchange mechanism.	Sulfhydryl Compounds	119-124	acetylserotonin O-methyltransferase	Rattus norvegicus	53-86
3036217-5	1987	These results suggest that adenosine kinase has at least two adenosine binding sites, one at the catalytic center and another quite distinct site at which binding of adenosine protects the reactive thiol group(s).	Sulfhydryl Compounds	198-203	adenosine kinase	Homo sapiens	27-43
3311021-1	1987	Rat intestinal mucin is polymerized by a putative "link" component of Mr 118,000 that can be released from the native mucin by thiol reduction [Fahim, Forstner & Forstner (1983) Biochem.	Sulfhydryl Compounds	127-132	solute carrier family 13 member 2	Rattus norvegicus	15-20
3311021-1	1987	Rat intestinal mucin is polymerized by a putative "link" component of Mr 118,000 that can be released from the native mucin by thiol reduction [Fahim, Forstner & Forstner (1983) Biochem.	Sulfhydryl Compounds	127-132	solute carrier family 13 member 2	Rattus norvegicus	118-123
3579919-1	1987	Endogenous thiols such as glutathione (GSH) are known to mediate the activity of bifunctional alkylating agents such as melphalan (L-PAM).	Sulfhydryl Compounds	11-17	peptidylglycine alpha-amidating monooxygenase	Mus musculus	133-136
3611046-5	1987	The lectin was inactivated by thiol-modifying reagents, p-chloromercuribenzoic acid and N-ethylmaleimide.	Sulfhydryl Compounds	30-35	galectin 3	Gallus gallus	4-10
3605592-1	1987	An enzyme catalyzing thiol-disulfide exchange, thioltransferase, was purified to homogeneity from pig liver.	Sulfhydryl Compounds	21-26	glutaredoxin-1	Sus scrofa	47-63
3828532-6	1987	The reduced methionine synthase activity was independent of assay reducing (thiol) conditions, but normal levels of activity accompanied culture of the patient"s lymphoblasts in medium with markedly increased cobalamin concentration.	Sulfhydryl Compounds	76-81	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	12-31
2440424-2	1987	The conformational changes around the thioester-bond region of human or bovine alpha 2M (alpha 2-macroglobulin) on reaction with methylamine or trypsin were studied with the probe AEDANS [N-(acetylaminoethyl)-8-naphthylamine-1-sulphonic acid], bound to the liberated thiol groups.	Sulfhydryl Compounds	267-272	pregnancy zone protein	Bos taurus	89-110
2440424-6	1987	Reaction of trypsin with thiol-labelled methylamine-treated bovine alpha 2M, which retains a near-native conformation and inhibitory activity, indicated that the major conformational change accompanying the binding of proteinases involves transfer of the thioester-bond region to a more polar environment without increasing the exposure of this region at the surface of the protein.	Sulfhydryl Compounds	25-30	alpha-2-macroglobulin	Bos taurus	67-75
3553404-5	1987	Immunoreactivity of microsomal HMG-CoA reductase was independent of the phosphorylation state of the enzyme, but was inversely related to the concentration of thiol-reducing agents present in the microsomal preparation up to 4 mM.	Sulfhydryl Compounds	159-164	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	31-48
3828351-5	1987	Thus it appears that the actin-binding site around the two thiols found in skeletal myosin is common to different types of myosin.	Sulfhydryl Compounds	59-65	actin alpha 2, smooth muscle	Sus scrofa	25-30
3828351-5	1987	Thus it appears that the actin-binding site around the two thiols found in skeletal myosin is common to different types of myosin.	Sulfhydryl Compounds	59-65	LOW QUALITY PROTEIN: myosin-10	Sus scrofa	84-90
3031563-8	1987	This apparently irreversible inhibition of CNP-ase activity by HgCl2 could be fully restored by the use of an excess of hydrophobic low molecular weight thiols, lipoic acid being the most efficient.	Sulfhydryl Compounds	153-159	2',3'-cyclic-nucleotide 3'-phosphodiesterase	Oryctolagus cuniculus	43-46
3031563-10	1987	Both low molecular weight thiols, and also EDTA in the case of inorganic mercury could prevent the inhibition of CNP-ase by mercurials, if preincubated for 15 min with the inhibitors, prior to the addition of the enzyme.	Sulfhydryl Compounds	26-32	2',3'-cyclic-nucleotide 3'-phosphodiesterase	Oryctolagus cuniculus	113-116
3031563-11	1987	The irreversible type of inhibition of CNP-ase by Met-Hg was only partially reversed in the presence of low molecular weight thiols.	Sulfhydryl Compounds	125-131	2',3'-cyclic-nucleotide 3'-phosphodiesterase	Oryctolagus cuniculus	39-42
3033467-0	1987	Oxidation of thiol drugs and biochemicals by the lactoperoxidase/hydrogen peroxide system.	Sulfhydryl Compounds	13-18	lactoperoxidase	Homo sapiens	49-64
3575754-6	1987	Experiments with PGA1-glutathione show that this sulfhydryl is not necessary for the catalytic activity of the enzyme as long as the substrate can bind at the glutathione site.	Sulfhydryl Compounds	49-59	autoimmune regulator	Homo sapiens	17-21
3304202-5	1987	Third, to test the hypothesis that the toxicity of DCVC is associated with the metabolic formation of a reactive thiol, S-(1,2-dichlorovinyl)-L-homocysteine (DCVHC), which may undergo a PLP-dependent gamma-elimination reaction to produce an identical thiol, was studied.	Sulfhydryl Compounds	113-118	pyridoxal phosphatase	Homo sapiens	186-189
3469673-1	1987	Sulfhydryl modification of 22 human erythrocyte enzymes was achieved by exposing intact erythrocytes, hemolysates, and partially purified enzymes to persulfides (RSSH) generated nonenzymatically from cystine in the presence of pyridoxal phosphate and mercaptopyruvate, which donates its sulfur to suitable acceptors with the mediation of the carrier enzyme, mercaptopyruvate sulfurtransferase (EC 2.8.1.2).	Sulfhydryl Compounds	0-10	mercaptopyruvate sulfurtransferase	Homo sapiens	358-392
2960154-4	1987	The above results suggest that inhibition of acyl-CoA:lysophosphatide acyltransferase (by interaction with thiol groups of the enzyme) is the mechanism underlying the thimerosal-induced EDRF production.	Sulfhydryl Compounds	107-112	alpha hemoglobin stabilizing protein	Homo sapiens	186-190
2979775-8	1987	In 2-acetylaminofluorene-treated rats, both thiols further stimulated glutathione S-transferase during the last treatment cycles and attenuated gamma-glutamyl transpeptidase activity, which however was not sufficient to thoroughly counteract the liver lesions due to the massive feeding of the carcinogen.	Sulfhydryl Compounds	44-50	hematopoietic prostaglandin D synthase	Rattus norvegicus	70-95
2979775-8	1987	In 2-acetylaminofluorene-treated rats, both thiols further stimulated glutathione S-transferase during the last treatment cycles and attenuated gamma-glutamyl transpeptidase activity, which however was not sufficient to thoroughly counteract the liver lesions due to the massive feeding of the carcinogen.	Sulfhydryl Compounds	44-50	gamma-glutamyltransferase 1	Rattus norvegicus	144-173
3327436-2	1987	ALAD is a zinc-dependent enzyme; thiol groups are essential for its activity; and in vitro experiments show that ALAD can be activated or inhibited by several metal ions including A;3+, Pb2+, Cd2+, Hg2+, Ag2+, and Cu2+.	Sulfhydryl Compounds	33-38	aminolevulinate dehydratase	Homo sapiens	0-4
3327436-2	1987	ALAD is a zinc-dependent enzyme; thiol groups are essential for its activity; and in vitro experiments show that ALAD can be activated or inhibited by several metal ions including A;3+, Pb2+, Cd2+, Hg2+, Ag2+, and Cu2+.	Sulfhydryl Compounds	33-38	aminolevulinate dehydratase	Homo sapiens	113-117
3442550-11	1987	Both the increase of the thiol content, and the shift of the SH/SS-equilibrium of the cellular proteins, correlated with a concomitant increase of enzymic activities such as gamma-glutamyltranspeptidase, glutathione reductase, glutathione peroxidase, glutathione S-transferase and 7-ethoxycoumarin O-deethylase.	Sulfhydryl Compounds	25-30	glutathione-disulfide reductase	Rattus norvegicus	204-225
3304202-5	1987	Third, to test the hypothesis that the toxicity of DCVC is associated with the metabolic formation of a reactive thiol, S-(1,2-dichlorovinyl)-L-homocysteine (DCVHC), which may undergo a PLP-dependent gamma-elimination reaction to produce an identical thiol, was studied.	Sulfhydryl Compounds	251-256	pyridoxal phosphatase	Homo sapiens	186-189
3492473-4	1987	Thus trans-2,5-Me2THF from cis-2,5-Me2THF and vice versa are formed in a chain reaction: at a dose rate of 2.8 X 10(-3) Gys-1 and a trans-2,5-Me2THF concentration of 1 X 10(-2) mol dm-3 using DTT as the thiol, G(cis-2,5-Me2THF) = 160 has been found.	Sulfhydryl Compounds	203-208	glycogen synthase 1	Homo sapiens	120-125
3581287-4	1987	trans-4-Hydroxy-alkenals and non-hydroxylated alpha,beta-unsaturated aldehydes may be exerting their effects on cytochrome P-450 by binding to sulfhydryl groups in a similar manner as reported for sulfhydryl reagents such as p-chloromercuriphenylsulfonic acid and p-chloromercuribenzoate.	Sulfhydryl Compounds	143-153	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	112-128
3583299-4	1987	The effects of some thiol reagents on red blood cell SAHH electrophoretic pattern have been investigated.	Sulfhydryl Compounds	20-25	adenosylhomocysteinase	Homo sapiens	53-57
3654004-4	1987	At concentrations of thiols that initiate the alternative pathway, the classical pathway was not or only to a minor extent activated; however, the activity of C2, C5 and one or several of the components C6-9 was directly affected.	Sulfhydryl Compounds	21-27	complement C6	Homo sapiens	203-207
3666282-0	1987	Altered thiol group status in the heart ornithine decarboxylase inactivated following perfusion with t-butylhydroperoxide.	Sulfhydryl Compounds	8-13	ornithine decarboxylase 1	Rattus norvegicus	40-63
3828286-6	1986	However, if single-strand nicks are introduced into the DNA backbone of core particles and other chromatin-like complexes by the action of DNase I, the influence of the DNA double helix upon thiol reactivity is reduced, and the effect of dimers can be detected once again.	Sulfhydryl Compounds	191-196	deoxyribonuclease 1	Bos taurus	139-146
2485059-4	1987	These and more recently developed ACE inhibitors can be classified according to their structural analogy to dipeptides or tripeptides and according to the nature of their zinc-binding ligands, such as sulfhydryl, ketone, carboxylate, or hydroxyphosphinyl, that contribute greatly to their binding to ACE.	Sulfhydryl Compounds	201-211	angiotensin I converting enzyme	Homo sapiens	34-37
3656273-4	1987	Experiments defined the conditions whereby two sulfhydryl-binding agents, p-hydroxymercuribenzoate (PHMB) and mersalyl, completely inhibited binding of the glucocorticoid receptor to ligand in mouse renal cytosol.	Sulfhydryl Compounds	47-57	nuclear receptor subfamily 3, group C, member 1	Mus musculus	156-179
2879564-1	1986	6-Thiocyanatoflavins have been found to be susceptible to nucleophilic displacement reactions with sulfite and thiols, yielding respectively the 6-S-SO3--flavin and 6-mercaptoflavin, with rate constants at pH 7.0, 20 degrees C, of 55 M-1 min-1 for sulfite and 1000 M-1 min-1 for dithiothreitol.	Sulfhydryl Compounds	111-117	CD59 molecule (CD59 blood group)	Homo sapiens	238-243
2877992-0	1986	Interaction of the D-isomer of gamma-methylene glutamate with an active site thiol of gamma-glutamylcysteine synthetase.	Sulfhydryl Compounds	77-82	glutamate-cysteine ligase catalytic subunit	Homo sapiens	86-119
2877992-1	1986	gamma-Glutamylcysteine synthetase has a thiol group in the vicinity of its glutamate-binding site.	Sulfhydryl Compounds	40-45	glutamate-cysteine ligase catalytic subunit	Homo sapiens	0-33
2879564-1	1986	6-Thiocyanatoflavins have been found to be susceptible to nucleophilic displacement reactions with sulfite and thiols, yielding respectively the 6-S-SO3--flavin and 6-mercaptoflavin, with rate constants at pH 7.0, 20 degrees C, of 55 M-1 min-1 for sulfite and 1000 M-1 min-1 for dithiothreitol.	Sulfhydryl Compounds	111-117	CD59 molecule (CD59 blood group)	Homo sapiens	269-274
3814093-2	1986	Cathepsin S was purified from bovine spleen by acid autolysis, (NH4)2SO4 fractionation and chromatography on CM-Sephadex C-50, CM-cellulose and activated-thiol-Sepharose.	Sulfhydryl Compounds	154-159	cathepsin S	Bos taurus	0-11
3028377-10	1986	The effect of a variety of inhibitors and activators on the amount of low Mr alkaline phosphatase produced during butanol extraction revealed that it was a Ca2+- and thiol-dependent process.	Sulfhydryl Compounds	166-171	AT695_RS04080	Staphylococcus aureus	77-97
2946674-0	1986	Thiol/disulfide redox equilibrium between glutathione and glycogen debranching enzyme (amylo-1,6-glucosidase/4-alpha-glucanotransferase) from rabbit muscle.	Sulfhydryl Compounds	0-5	glycogen debranching enzyme	Oryctolagus cuniculus	87-135
3028377-14	1986	Since this activity was acid active, Ca2+- and thiol-dependent and relatively heat stable, it may be the same as that responsible for production of low Mr alkaline phosphatase.	Sulfhydryl Compounds	47-52	AT695_RS04080	Staphylococcus aureus	155-175
3467317-2	1986	Assembly-competent myosin molecules labeled with the sulfhydryl-specific fluorochromes 5-(2-[(iodoacetyl)-amino]ethyl)aminonaphthalene-1-sulfonic acids (IAEDANS) or 5-iodoacetamidofluorescein (IAF) were prepared.	Sulfhydryl Compounds	53-63	myosin heavy chain 14	Homo sapiens	19-25
3535804-2	1986	Thiols, such as glutathione and cysteine, are mutagenic in the Ames test, using Salmonella typhimurium strain TA 100 and rat kidney S-9 preparation [Glatt et al.	Sulfhydryl Compounds	0-6	ribosomal protein S9	Homo sapiens	132-135
3533923-1	1986	We have studied the sensitivity of sulfhydryl groups of a highly purified p21 protein of the v-rasH oncogene to a thiol-specific reagent, N-ethylmaleimide (NEM).	Sulfhydryl Compounds	114-119	H3 histone pseudogene 16	Homo sapiens	74-77
3093479-7	1986	These data suggest that p32 and p34 are closely regulated human and murine gene products, respectively, whose synthesis can be modulated by thiol-reactive reagents.	Sulfhydryl Compounds	140-145	inhibitor of growth family member 2	Homo sapiens	24-27
2877829-5	1986	Apoferritin (a thiol-containing protein), native microsomes, and, to a lesser extent, boiled microsomes catalyze the reaction, but their activity is reduced or eliminated by prior incubation with iodoacetate.	Sulfhydryl Compounds	15-20	ferritin heavy chain 1	Homo sapiens	0-11
3103252-1	1986	We have studied the effects of the mucolytic thiol agent mercapto-ethanesulphonate (mesna) on the activity of both polymorphonuclear leucocyte (PMN) elastase and antileucoprotease in vitro.	Sulfhydryl Compounds	45-50	elastase, neutrophil expressed	Homo sapiens	115-157
3103252-11	1986	It is concluded that mesna and other thiol compounds, when locally administered, may influence the proteinase-antiproteinase balance in the airways by their effect on both PMN elastase and antileucoprotease.	Sulfhydryl Compounds	37-42	elastase, neutrophil expressed	Homo sapiens	172-184
2947624-1	1986	The thiol of the gizzard myosin heavy chain, which reacts most rapidly with N-ethylmaleimide (MalNEt), has been located in the subfragment 2 region of myosin rod by fragmentation of [14C]-MalNEt-labeled myosin with papain and chymotrypsin.	Sulfhydryl Compounds	4-9	myosin heavy chain 14	Homo sapiens	25-31
2947624-1	1986	The thiol of the gizzard myosin heavy chain, which reacts most rapidly with N-ethylmaleimide (MalNEt), has been located in the subfragment 2 region of myosin rod by fragmentation of [14C]-MalNEt-labeled myosin with papain and chymotrypsin.	Sulfhydryl Compounds	4-9	myosin heavy chain 14	Homo sapiens	151-157
2947624-3	1986	The reaction of MalNEt with thiols present in these regions is increased on addition of ATP by factors of 2 and 10, respectively, when myosin is modified in 0.45 M NaCl where it is present in the extended, 6S conformation.	Sulfhydryl Compounds	28-34	myosin heavy chain 14	Homo sapiens	135-141
3790516-1	1986	The fluorescence polarization from rhodamine labels specifically attached to the fast-reacting thiol of the myosin cross-bridge in glycerinated muscle fibers has been measured to determine the angular distribution of the cross-bridges in different physiological states of the fibers as a function of temperature.	Sulfhydryl Compounds	95-100	myosin heavy chain 14	Homo sapiens	108-114
3759951-0	1986	Thiol/disulfide redox equilibrium and kinetic behavior of chicken liver fatty acid synthase.	Sulfhydryl Compounds	0-5	fatty acid synthase	Gallus gallus	72-91
3093479-7	1986	These data suggest that p32 and p34 are closely regulated human and murine gene products, respectively, whose synthesis can be modulated by thiol-reactive reagents.	Sulfhydryl Compounds	140-145	alpha and gamma adaptin binding protein	Homo sapiens	32-35
3757165-11	1986	These data support the notion that thiols play an important role in protection against carcinogen damage, and that synthetic thiols such as alpha MPG and NAC may be useful as anti-carcinogenic agents against certain carcinogens.	Sulfhydryl Compounds	125-131	N-methylpurine-DNA glycosylase	Rattus norvegicus	146-149
2876891-3	1986	Following reaction of ATPase with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole or N,N"-dicyclohexylcarbodiimide, the alpha and beta subunits of the uncA401, but not of the uncD412 mutant F1 ATPase were intensely labeled by a fluorescent thiol reagent.	Sulfhydryl Compounds	232-237	ATPase	Escherichia coli	22-28
2876891-13	1986	As in wild-type ATPase, labeling of membrane-bound unc mutant ATPase by a fluorescent thiol reagent modified the alpha subunits.	Sulfhydryl Compounds	86-91	ATPase	Escherichia coli	16-22
2876891-13	1986	As in wild-type ATPase, labeling of membrane-bound unc mutant ATPase by a fluorescent thiol reagent modified the alpha subunits.	Sulfhydryl Compounds	86-91	ATPase	Escherichia coli	62-68
3021207-0	1986	Covalent attachment of sulfhydryl-specific, electron spin resonance spin-labels to Fab" fragments of murine monoclonal antibodies that recognize human platelet membrane glycoproteins.	Sulfhydryl Compounds	23-33	FA complementation group B	Homo sapiens	83-86
3761306-2	1986	We found that stypoldione binds covalently to sulfhydryl groups of thiol-containing compounds via addition of sulfur to the C-4" position of the quinone ring.	Sulfhydryl Compounds	67-72	complement C4A (Rodgers blood group)	Homo sapiens	124-127
3022802-7	1986	These data suggest that a sensitive thiol group that affects hormone binding resides in the glucagon receptor, which may be a transmembrane protein.	Sulfhydryl Compounds	36-41	glucagon receptor	Mus musculus	92-109
2430627-5	1986	Singlet--singlet energy transfer measurements from the donor pyrene labeled active center of the proteases to the alpha 2-macroglobulin acceptor labeled thiol groups which are liberated upon protease fixation, gave a rough estimate of the distance (about 25 A) between the active center of the two alpha 2-macroglobulin bound protease molecules.	Sulfhydryl Compounds	153-158	alpha-2-macroglobulin	Homo sapiens	114-135
2430627-5	1986	Singlet--singlet energy transfer measurements from the donor pyrene labeled active center of the proteases to the alpha 2-macroglobulin acceptor labeled thiol groups which are liberated upon protease fixation, gave a rough estimate of the distance (about 25 A) between the active center of the two alpha 2-macroglobulin bound protease molecules.	Sulfhydryl Compounds	153-158	alpha-2-macroglobulin	Homo sapiens	298-319
3790140-0	1986	Dinitrophenylated thiols in tryptic fragments of the heavy chain from chicken gizzard myosin.	Sulfhydryl Compounds	18-24	myosin, heavy chain 15	Gallus gallus	86-92
3790140-7	1986	Phosphorylation induced conformational changes in gizzard myosin that altered the reactivity of the thiols in fragments of the globular heavy chain region.	Sulfhydryl Compounds	100-106	myosin, heavy chain 15	Gallus gallus	58-64
3746818-0	1986	Thiol addition to quinones: model reactions for the inactivation of thymidylate synthase by 5-p-benzoquinonyl-2"-deoxyuridine 5"-phosphate.	Sulfhydryl Compounds	0-5	thymidylate synthetase	Homo sapiens	68-88
2943222-8	1986	Together these data suggest that cytochrome P-450 reduces the activity of the microsomal ATP-dependent calcium pump both by the production of hydrogen peroxide and by the direct oxidation of the protein thiols.	Sulfhydryl Compounds	203-209	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
3755373-0	1986	Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.	Sulfhydryl Compounds	86-91	cathepsin L	Mus musculus	26-48
2877456-3	1986	Ca2+-dependent activation of factor XIIIa by thrombin removes a blocked amino-terminal peptide and unmasks a reactive thiol group at Cys-314.	Sulfhydryl Compounds	118-123	coagulation factor XIII A chain	Homo sapiens	29-41
2877456-3	1986	Ca2+-dependent activation of factor XIIIa by thrombin removes a blocked amino-terminal peptide and unmasks a reactive thiol group at Cys-314.	Sulfhydryl Compounds	118-123	coagulation factor II, thrombin	Homo sapiens	45-53
3800926-2	1986	Benzofuroxan reacts with the catalytic-site thiol group of cathepsin B (EC 3.4.22.1) to produce stoichiometric amount of the chromophoric reduction product, o-benzoquinone dioxime.	Sulfhydryl Compounds	44-49	cathepsin B	Rattus norvegicus	59-70
3017407-6	1986	Gelsolin contained only two accessible thiol groups per mole of protein, one of which was titratable in the native protein; it was more accessible to 5,5"-dithiobis(2-nitrobenzoic acid) in the absence than in the presence of Ca2+.	Sulfhydryl Compounds	39-44	gelsolin	Bos taurus	0-8
3026330-5	1986	Additionally, the thiol reagent N-ethylmalemide (NEM) at rather low concentrations abolished thrombin- and adrenaline-induced stimulation of GTP hydrolysis was decreased by only 30-40% by treatment of platelet membranes with even high concentrations of NEM.	Sulfhydryl Compounds	18-23	coagulation factor II, thrombin	Homo sapiens	93-101
3018374-3	1986	Chemical reaction of estradiol-2, 3-O-quinone with various thiols showed that alkyl and phenyl thiols gave about a 1:1 ratio of C-4 to C-1 thioethers.	Sulfhydryl Compounds	59-65	complement C4A	Rattus norvegicus	128-131
3015030-12	1986	Thiol induced changes that corresponded to the formation of catalase complex II.	Sulfhydryl Compounds	0-5	catalase	Bos taurus	60-68
2873139-1	1986	Lung matrix-associated transglutaminase: characterization and activation with sulfhydryls.	Sulfhydryl Compounds	78-89	protein-glutamine gamma-glutamyltransferase 2	Cavia porcellus	23-39
3781808-5	1986	At 10 mM concentration of the thiol, complete inhibition of both the esterification by ACAT and the hydrolysis occur.	Sulfhydryl Compounds	30-35	sterol O-acyltransferase 1	Homo sapiens	87-91
3014498-7	1986	Such an abolishment was achieved by treating EF-Tu extensively with the thiol reagent L-1-tosylamido-2-phenylethyl chloromethyl ketone.	Sulfhydryl Compounds	72-77	Tu translation elongation factor, mitochondrial	Homo sapiens	45-50
3718529-0	1986	Thiol stimulation of the cytochrome P-450-dependent reduction of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD).	Sulfhydryl Compounds	0-5	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	25-41
3019315-9	1986	These observations suggest that the thiol redox state of the IGF-I receptor in vivo is an important determinant of receptor conformation and therefore of the biological responses to IGF-I.	Sulfhydryl Compounds	36-41	insulin like growth factor 1 receptor	Homo sapiens	61-75
3019315-9	1986	These observations suggest that the thiol redox state of the IGF-I receptor in vivo is an important determinant of receptor conformation and therefore of the biological responses to IGF-I.	Sulfhydryl Compounds	36-41	insulin like growth factor 1	Homo sapiens	61-66
3092812-0	1986	A thiol-sensitive degradative process of liver uncouples autophosphorylation of the insulin receptor from insulin binding.	Sulfhydryl Compounds	2-7	insulin receptor	Rattus norvegicus	84-100
3092812-6	1986	Thus a thiol-sensitive, cation-dependent, degrading activity has been identified that can uncouple the insulin-binding activity of the plasma-membrane insulin receptor from its tyrosine kinase activity.	Sulfhydryl Compounds	7-12	insulin receptor	Rattus norvegicus	151-167
3527172-1	1986	D(-)beta-hydroxybutyrate dehydrogenase (BDH) purified from bovine heart mitochondria contains essential thiol and carboxyl groups.	Sulfhydryl Compounds	104-109	3-hydroxybutyrate dehydrogenase 1	Bos taurus	0-38
3527172-1	1986	D(-)beta-hydroxybutyrate dehydrogenase (BDH) purified from bovine heart mitochondria contains essential thiol and carboxyl groups.	Sulfhydryl Compounds	104-109	3-hydroxybutyrate dehydrogenase 1	Bos taurus	40-43
3527172-7	1986	These results suggest that the essential thiol of BDH is located at its nucleotide-binding site, and agree with our previous observation that NAD and NADH protect BDH against inhibition by thiol modifiers.	Sulfhydryl Compounds	41-46	3-hydroxybutyrate dehydrogenase 1	Bos taurus	50-53
3527172-7	1986	These results suggest that the essential thiol of BDH is located at its nucleotide-binding site, and agree with our previous observation that NAD and NADH protect BDH against inhibition by thiol modifiers.	Sulfhydryl Compounds	41-46	3-hydroxybutyrate dehydrogenase 1	Bos taurus	163-166
3527172-7	1986	These results suggest that the essential thiol of BDH is located at its nucleotide-binding site, and agree with our previous observation that NAD and NADH protect BDH against inhibition by thiol modifiers.	Sulfhydryl Compounds	189-194	3-hydroxybutyrate dehydrogenase 1	Bos taurus	50-53
3698895-0	1986	Thiol regulation of depletion-transformation and release of prolactin by the pituitary of the lactating rat.	Sulfhydryl Compounds	0-5	prolactin	Rattus norvegicus	60-69
3527172-7	1986	These results suggest that the essential thiol of BDH is located at its nucleotide-binding site, and agree with our previous observation that NAD and NADH protect BDH against inhibition by thiol modifiers.	Sulfhydryl Compounds	189-194	3-hydroxybutyrate dehydrogenase 1	Bos taurus	163-166
3521603-5	1986	The data suggest that insulin acts by increasing the portion of HMG-CoA reductase present in its active free sulfhydryl form.	Sulfhydryl Compounds	109-119	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	64-81
2942700-6	1986	Two of the anti-25k antibodies affect the K+-EDTA-and Ca2+-ATPase activities of myosin in a manner that mimics the effect on activity of the modification of the reactive thiol, SH-1.	Sulfhydryl Compounds	170-175	myosin, heavy chain 15	Gallus gallus	80-86
3698895-1	1986	We investigated the possibility that thiol-disulfide interchange mechanisms are involved in depletion-transformation (loss of tissue PRL detectability) and release of PRL from adenohypophyses (AP) of lactating rats.	Sulfhydryl Compounds	37-42	prolactin	Rattus norvegicus	133-136
3698895-1	1986	We investigated the possibility that thiol-disulfide interchange mechanisms are involved in depletion-transformation (loss of tissue PRL detectability) and release of PRL from adenohypophyses (AP) of lactating rats.	Sulfhydryl Compounds	37-42	prolactin	Rattus norvegicus	167-170
3698895-12	1986	Thus, thiols and aminothiols may preferentially lead to depletion-transformation of PRL, whereas disulfides may inhibit depletion and facilitate PRL release.	Sulfhydryl Compounds	6-12	prolactin	Rattus norvegicus	84-87
3698895-13	1986	Although in some experiments increased depletion was dissociated from increased release, nonetheless the data support the concept that shifts in PRL detectability during depletion-transformation, repletion, and release involve thiol-disulfide interchange mechanisms.	Sulfhydryl Compounds	227-232	prolactin	Rattus norvegicus	145-148
3698896-2	1986	The present studies were designed to determine whether thiol-disulfide interchange mechanisms may be involved in PRL transformation and release by the pituitary of the lactating rat.	Sulfhydryl Compounds	55-60	prolactin	Rattus norvegicus	113-116
3698896-6	1986	On the other hand, when thiols were added in addition to the above agents, a complete, dose-related, restoration of PRL depletion was obtained.	Sulfhydryl Compounds	24-30	prolactin	Rattus norvegicus	116-119
3698896-8	1986	Other data indicate that thiols alone may inhibit rat PRL release and also facilitate or induce PRL depletion; in bovine PRL granules, thiols reverse Zn++ inhibition of PRL release and detectability.	Sulfhydryl Compounds	25-31	prolactin	Rattus norvegicus	54-57
3698896-8	1986	Other data indicate that thiols alone may inhibit rat PRL release and also facilitate or induce PRL depletion; in bovine PRL granules, thiols reverse Zn++ inhibition of PRL release and detectability.	Sulfhydryl Compounds	25-31	prolactin	Rattus norvegicus	96-99
3698896-8	1986	Other data indicate that thiols alone may inhibit rat PRL release and also facilitate or induce PRL depletion; in bovine PRL granules, thiols reverse Zn++ inhibition of PRL release and detectability.	Sulfhydryl Compounds	25-31	prolactin	Bos taurus	96-99
3698896-8	1986	Other data indicate that thiols alone may inhibit rat PRL release and also facilitate or induce PRL depletion; in bovine PRL granules, thiols reverse Zn++ inhibition of PRL release and detectability.	Sulfhydryl Compounds	25-31	prolactin	Bos taurus	96-99
18555370-1	1986	Purified rat liver phenylalanine hydroxylase [L-phenylalanine:tetrahydropteridine:oxygen oxidoreductase (4-hydroxylating), EC 1.14.16.1] was immobilized with activated thiol-Sepharose 4B via disulfide bond formation, which is expected to immobilize the enzyme in its activated form through the SH modification.	Sulfhydryl Compounds	168-173	phenylalanine hydroxylase	Rattus norvegicus	19-44
2420367-9	1986	Subsequent thiol reduction, however, abolished the antigenicity of the deglycosylated mucin.	Sulfhydryl Compounds	11-16	LOC100508689	Homo sapiens	86-91
3702453-1	1986	Sulfhydryl reducing agents such as dithiothreitol are required for maximum binding of dexamethasone to the mammary cytosolic glucocorticoid receptor, but little is known concerning the effects of dithiothreitol on the kinetics of the binding reaction.	Sulfhydryl Compounds	0-10	nuclear receptor subfamily 3 group C member 1	Homo sapiens	125-148
3700170-4	1986	Thiol depletion was achieved using two agents that work by totally different mechanisms--one a substrate for glutathione-S-transferase (Diethylmaleate) and the other an inhibitor of a key enzyme in the gamma-glutamyl cycle (Buthionine-SR-Sulfoximine).	Sulfhydryl Compounds	0-5	glutathione S-transferase kappa 1	Homo sapiens	109-134
2938184-1	1986	When myosin subfragment 1 derivatives in which the reactive sulfhydryl SH1 has been blocked react with N,N"-p-phenylenedimaleimide or 5,5"-dithiobis(2-nitrobenzoic acid), the reactive sulfhydryl group SH2 of the 20-kDa domain is crosslinked with a thiol of the 50-kDa domain of the heavy chain.	Sulfhydryl Compounds	248-253	myosin heavy chain 14	Homo sapiens	5-11
3730532-3	1986	Thiol groups of non-histone chromatin proteins, which amount to about 40 nmol/mg of protein, are preferentially located in chromatin fragments which are more easily solubilised either by DNAse I or by DNAse II.	Sulfhydryl Compounds	0-5	deoxyribonuclease 1	Sus scrofa	187-194
3526299-7	1986	In contrast, dynorphin(1-13), an inhibitor of a soluble, thiol dependent metallopeptidase which hydrolyses neurotensin at Arg8-Arg9, gave greater than 80% inhibition of 3H-neurotensin degradation in the slice preparation.	Sulfhydryl Compounds	57-62	endothelin converting enzyme-like 1	Rattus norvegicus	73-89
3081777-0	1986	Cysteamine, zinc, and thiols modify detectability of rat pituitary prolactin: a comparison with effects on bovine prolactin suggests differences in hormone storage.	Sulfhydryl Compounds	22-28	prolactin	Rattus norvegicus	67-76
3526299-7	1986	In contrast, dynorphin(1-13), an inhibitor of a soluble, thiol dependent metallopeptidase which hydrolyses neurotensin at Arg8-Arg9, gave greater than 80% inhibition of 3H-neurotensin degradation in the slice preparation.	Sulfhydryl Compounds	57-62	neurotensin	Rattus norvegicus	107-118
3526299-11	1986	This evidence suggests that this thiol dependent metalloendopeptidase is the major neurotensin catabolizing enzyme in hypothalamic slices.	Sulfhydryl Compounds	33-38	thimet oligopeptidase 1	Rattus norvegicus	49-69
3526299-11	1986	This evidence suggests that this thiol dependent metalloendopeptidase is the major neurotensin catabolizing enzyme in hypothalamic slices.	Sulfhydryl Compounds	33-38	neurotensin	Rattus norvegicus	83-94
3030364-0	1986	[Effect of mercaptans on serum IgA].	Sulfhydryl Compounds	11-21	CD79a molecule	Homo sapiens	31-34
2935197-2	1986	At 1 X 10(-7) M Ca2+, 0.2 mM mersalyl, which represents approximately the equivalent amount of sulfhydryl of platelet suspensions that we used, specifically made myosin insoluble.	Sulfhydryl Compounds	95-105	myosin heavy chain 14	Homo sapiens	162-168
3955026-5	1986	U.S.A. 80, 4909-4913], myosin subfragment 1 that was modified by having its two reactive thiol groups cross-linked by N,N"-p-phenylenedimaleimide (pPDM) was found to resemble the myosin subfragment 1-adenosine 5"-triphosphate (S-1.ATP) complex in its interaction with actin.	Sulfhydryl Compounds	89-94	myosin heavy chain 14	Homo sapiens	23-29
3084462-4	1986	Acid beta-galactosidase was characterized as a thiol enzyme which was inactivated by a mercuric compound.	Sulfhydryl Compounds	47-52	galactosidase beta 1	Homo sapiens	0-23
30959627-0	1986	Relationship of Somatic Cell Count and Total Sulfhydryls in Milk.	Sulfhydryl Compounds	45-56	Weaning weight-maternal milk	Bos taurus	60-64
2867900-0	1986	Thiol modification as a probe of conformational forms of the F1 ATPase of Escherichia coli and of the structural asymmetry of its beta subunits.	Sulfhydryl Compounds	0-5	ATPase	Escherichia coli	64-70
2415613-5	1986	The thiol (-SH) group of D-Pen was required for generating effective stimulator cells; other thiol compounds, however, or heavy metals (Hg, Au) were unable to generate cross-reacting stimulators on incubation with spleen cells.	Sulfhydryl Compounds	4-9	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	27-30
3709933-4	1986	The aggregated AP-A was dissociated into an intermediate form with Triton X-100 and/or sodium deoxycholate and further into two low-molecular-weight forms with thiol compounds and neuraminidase.	Sulfhydryl Compounds	160-165	glutamyl aminopeptidase	Bos taurus	15-19
3536279-3	1986	Rhesus monkey alpha 1-antitrypsin contained a reactive thiol.	Sulfhydryl Compounds	55-60	serpin family A member 1	Macaca mulatta	14-33
3957895-3	1986	The nitrite production was significantly reduced when thiols of myosin were modified with 2-nitro-5-thiocyanobenzoate.	Sulfhydryl Compounds	54-60	myosin, heavy chain 15	Gallus gallus	64-70
2418059-9	1986	The thrombin-induced PA-I inhibited both tPA and urokinase, did not lose activity upon acidification, and was stable to sodium dodecyl sulfate and thiol reduction.	Sulfhydryl Compounds	147-152	coagulation factor II, thrombin	Homo sapiens	4-12
2418059-9	1986	The thrombin-induced PA-I inhibited both tPA and urokinase, did not lose activity upon acidification, and was stable to sodium dodecyl sulfate and thiol reduction.	Sulfhydryl Compounds	147-152	serpin family E member 1	Homo sapiens	21-25
4066714-0	1985	Sulfhydryl/disulfide forms of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase.	Sulfhydryl Compounds	0-10	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	40-87
3097260-2	1986	A covalently bound metabolite is formed by MAO-B in vitro from MPTP, through a reaction almost completely inhibited by physiological concentrations of glutathione and significantly reduced by other sulfhydryl containing compounds.	Sulfhydryl Compounds	198-208	monoamine oxidase B	Rattus norvegicus	43-48
2880383-6	1986	The effects in the liver of the exogenously supplied thiols during 2-acetylaminofluorene treatment were assessed evaluating DNA damage, glutathione levels, activity of marker enzymes glucose-6-phosphatase, gamma-glutamyltranspeptidase, and glutathione-S-transferase, survival rates, and development of salivary gland tumors.	Sulfhydryl Compounds	53-59	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	183-204
24258016-6	1985	It is suggested that selenium protects essential thiol groups in ALAD that are otherwise blocked by invading tin; in contrast, selenium, under similar conditions, does not prevent interactions of lead with enzyme thiol groups.	Sulfhydryl Compounds	49-54	aminolevulinate, delta-, dehydratase	Mus musculus	65-69
2868545-0	1985	Factor XIII catalyzed formation of fibrinogen-fibronectin oligomers--a thiol enhanced process.	Sulfhydryl Compounds	71-76	fibrinogen beta chain	Homo sapiens	35-45
2868545-0	1985	Factor XIII catalyzed formation of fibrinogen-fibronectin oligomers--a thiol enhanced process.	Sulfhydryl Compounds	71-76	fibronectin 1	Homo sapiens	46-57
4062957-1	1985	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic thiol compounds including drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine.	Sulfhydryl Compounds	93-98	thiopurine methyltransferase	Mus musculus	0-28
4062957-1	1985	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic thiol compounds including drugs such as 6-mercaptopurine (6-MP) and 6-thioguanine.	Sulfhydryl Compounds	93-98	thiopurine methyltransferase	Mus musculus	30-34
2415115-1	1985	The kinetics of the reaction of alpha 2-macroglobulin (alpha 2M) with human thrombin were studied by recording the appearance of thiol groups spectrophotometrically and by measuring the distribution of protein species by denaturing non-reducing gel electrophoresis.	Sulfhydryl Compounds	129-134	alpha-2-macroglobulin	Homo sapiens	32-53
2415115-1	1985	The kinetics of the reaction of alpha 2-macroglobulin (alpha 2M) with human thrombin were studied by recording the appearance of thiol groups spectrophotometrically and by measuring the distribution of protein species by denaturing non-reducing gel electrophoresis.	Sulfhydryl Compounds	129-134	alpha-2-macroglobulin	Homo sapiens	55-63
2415115-1	1985	The kinetics of the reaction of alpha 2-macroglobulin (alpha 2M) with human thrombin were studied by recording the appearance of thiol groups spectrophotometrically and by measuring the distribution of protein species by denaturing non-reducing gel electrophoresis.	Sulfhydryl Compounds	129-134	coagulation factor II, thrombin	Homo sapiens	76-84
2415115-4	1985	The observed second-order rate constant for thiol-group release was found to be faster than the second-order rate constant for the disappearance of the band corresponding to native alpha 2M on gel electrophoresis.	Sulfhydryl Compounds	44-49	alpha-2-macroglobulin	Homo sapiens	181-189
2415116-0	1985	Binding of proteinases to human alpha 2-macroglobulin with its thioester bonds cleaved by methylamine in the presence of a thiol-group-cyanylating reagent.	Sulfhydryl Compounds	123-128	alpha-2-macroglobulin	Homo sapiens	32-53
4062902-7	1985	S-protein was found to be an acidic glycoprotein with 10% (W/W) carbohydrate content and several isoelectric points in the range pH 4.75-5.25, and it contained one free thiol group per molecule of protein.	Sulfhydryl Compounds	169-174	vitronectin	Homo sapiens	0-9
2996427-5	1985	This affinity purified CANP had properties previously described for other CANPs: heterodimer of 80 and 30 kDa; neutral pH optimum; activation by millimolar Ca2+; and inhibition by an endogenous, heat-stable proteinaceous inhibitor, by leupeptin, and by sulfhydryl alkylating agents.	Sulfhydryl Compounds	253-263	calpain 1	Homo sapiens	23-27
2864083-1	1985	Rabbit liver arylsulfatase A (aryl-sulfate sulfhydrolase, EC 3.1.6.1) monomers of 130 kDa contain two free sulfhydryl groups as determined by spectrophotometric titration using 5,5"-dithiobis(2-nitrobenzoate) and by labeling with the fluorescent probe 5-(iodoacetamidoethyl)aminonaphthalene-1-sulfonic acid.	Sulfhydryl Compounds	107-117	arylsulfatase A	Oryctolagus cuniculus	13-28
2934089-6	1985	However, it did label GPIb beta in sonicated platelets, indicating that the thiol group of GPIb beta occupies an intracellular location.	Sulfhydryl Compounds	76-81	glycoprotein Ib platelet subunit beta	Homo sapiens	91-100
3929690-6	1985	Bovine carbonic anhydrase III contains five thiol groups, two of which react readily with Ellman"s reagent without effect on the catalytic activity.	Sulfhydryl Compounds	44-49	carbonic anhydrase 3	Bos taurus	7-29
4018271-1	1985	Human kappa-casein was prepared from whole casein by successive hydroxyapatite and thiol-Sepharose chromatographies.	Sulfhydryl Compounds	83-88	casein kappa	Homo sapiens	6-18
3893547-0	1985	Activation of bee venom phospholipase A2 by oleoyl imidazolide produces a thiol- and proteinase-resistant conformation.	Sulfhydryl Compounds	74-79	phospholipase A2 group IB	Homo sapiens	24-40
2989266-1	1985	Ubiquitin carboxyl-terminal hydrolase (formerly known as ubiquitin carboxyl-terminal esterase), from rabbit reticulocytes, has been shown to hydrolyze thiol esters formed between the ubiquitin carboxyl terminus and small thiols (e.g. glutathione), as well as free ubiquitin adenylate (Rose, I.	Sulfhydryl Compounds	221-227	ubiquitin	Oryctolagus cuniculus	0-9
2989266-1	1985	Ubiquitin carboxyl-terminal hydrolase (formerly known as ubiquitin carboxyl-terminal esterase), from rabbit reticulocytes, has been shown to hydrolyze thiol esters formed between the ubiquitin carboxyl terminus and small thiols (e.g. glutathione), as well as free ubiquitin adenylate (Rose, I.	Sulfhydryl Compounds	221-227	ubiquitin	Oryctolagus cuniculus	57-66
2989266-1	1985	Ubiquitin carboxyl-terminal hydrolase (formerly known as ubiquitin carboxyl-terminal esterase), from rabbit reticulocytes, has been shown to hydrolyze thiol esters formed between the ubiquitin carboxyl terminus and small thiols (e.g. glutathione), as well as free ubiquitin adenylate (Rose, I.	Sulfhydryl Compounds	221-227	ubiquitin	Oryctolagus cuniculus	183-192
2989266-1	1985	Ubiquitin carboxyl-terminal hydrolase (formerly known as ubiquitin carboxyl-terminal esterase), from rabbit reticulocytes, has been shown to hydrolyze thiol esters formed between the ubiquitin carboxyl terminus and small thiols (e.g. glutathione), as well as free ubiquitin adenylate (Rose, I.	Sulfhydryl Compounds	221-227	ubiquitin	Oryctolagus cuniculus	183-192
3874077-8	1985	Furthermore, after depletion of monocytes IL 2 production by peripheral T cells became almost completely dependent on the presence of thiols in the culture medium.	Sulfhydryl Compounds	134-140	interleukin 2	Homo sapiens	42-46
3928592-2	1985	The conjugate was prepared by a novel and convenient procedure devised to couple an amino group of CL to thiol groups of bovine serum albumin (BSA) introduced by thiol exchange reduction of its disulfide bonds with dithiothreitol, using N-(m-maleimidobenzoyloxy)succinimide (MBS) as a cross-linker.	Sulfhydryl Compounds	105-110	LOC100136344	Oncorhynchus mykiss	128-141
3928592-2	1985	The conjugate was prepared by a novel and convenient procedure devised to couple an amino group of CL to thiol groups of bovine serum albumin (BSA) introduced by thiol exchange reduction of its disulfide bonds with dithiothreitol, using N-(m-maleimidobenzoyloxy)succinimide (MBS) as a cross-linker.	Sulfhydryl Compounds	162-167	LOC100136344	Oncorhynchus mykiss	128-141
3840720-7	1985	Cytotoxic effects of these sulfhydryl compounds were observed in the same concentration range as that for cysteamine (0-2 mM), but only if cells were plated at low densities (10(2)-10(4) cells/flask), and were completely blocked by the addition of catalase (50 micrograms/ml).	Sulfhydryl Compounds	27-37	catalase	Cricetulus griseus	248-256
2866798-8	1985	Consistent with this view, the thiol reagent S-methyl methanethiosulfonate inactivated factor XIIIa, blocked cross-linking of fibrin, and protected against loss of its promoter activity.	Sulfhydryl Compounds	31-36	coagulation factor XIII A chain	Homo sapiens	87-99
4065147-4	1985	The formation of correct disulphide pairing in prolactin (band III), synthesised in the in vitro translation system in the presence of pancreatic microsomes, required the presence of a thiol oxidant such as oxidised glutathione during the translation.	Sulfhydryl Compounds	185-190	prolactin	Bos taurus	47-56
4065147-5	1985	The action of thiol oxidants on the in vitro biosynthesised and microsomally processed prolactin were both dose-dependent and catalytic; non-thiol oxidants such as NAD+ and NADP+ were ineffective.	Sulfhydryl Compounds	14-19	prolactin	Bos taurus	87-96
4065147-5	1985	The action of thiol oxidants on the in vitro biosynthesised and microsomally processed prolactin were both dose-dependent and catalytic; non-thiol oxidants such as NAD+ and NADP+ were ineffective.	Sulfhydryl Compounds	141-146	prolactin	Bos taurus	87-96
2998407-0	1985	Antiarthritic drugs containing thiol groups scavenge hypochlorite and inhibit its formation by myeloperoxidase from human leukocytes.	Sulfhydryl Compounds	31-36	myeloperoxidase	Homo sapiens	95-110
3003044-4	1985	These results, together with the sequence analysis, indicated that the three cysteine residues in cytochrome c1 heme subunit not involved in heme-binding existed in free thiol form.	Sulfhydryl Compounds	170-175	cytochrome c1	Bos taurus	98-111
2865352-3	1985	One possible pathway for the biotransformation of thiol compounds such as MTT is S-methylation catalyzed by either thiopurine methyltransferase (TPMT), a soluble enzyme, or by thiol methyltransferase, a microsomal enzyme.	Sulfhydryl Compounds	50-55	thiopurine S-methyltransferase	Homo sapiens	115-143
2865352-3	1985	One possible pathway for the biotransformation of thiol compounds such as MTT is S-methylation catalyzed by either thiopurine methyltransferase (TPMT), a soluble enzyme, or by thiol methyltransferase, a microsomal enzyme.	Sulfhydryl Compounds	50-55	thiopurine S-methyltransferase	Homo sapiens	145-149
2865352-9	1985	Maximal velocity (Vmax) values for the S-methylation of MTD catalyzed by TPMT and by human liver microsomes were 3.58- and 678-fold greater than were those for the thiol methylation of MTT.	Sulfhydryl Compounds	164-169	thiopurine S-methyltransferase	Homo sapiens	73-77
4079377-0	1985	Covalent chromatography by thiol-disulfide interchange of the highly-purified non-transformed rat liver glucocorticoid-receptor.	Sulfhydryl Compounds	27-32	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	104-127
4052110-0	1985	On the role of thiol groups in the inhibition of liver microsomal Ca2+ sequestration by toxic agents.	Sulfhydryl Compounds	15-20	carbonic anhydrase 2	Rattus norvegicus	66-69
4052110-5	1985	It is concluded that microsomal Ca2+ sequestration is critically dependent on protein sulfhydryl groups, and that modification of protein thiols may be an important mechanism for the inhibition of microsomal Ca2+ sequestration by a variety of toxic agents.	Sulfhydryl Compounds	138-144	carbonic anhydrase 2	Rattus norvegicus	208-211
3899711-0	1985	Nonspecific reaction of a thiol: protein disulfide oxidoreductase with the disulfide bonds of insulin.	Sulfhydryl Compounds	26-31	insulin	Bos taurus	94-101
3876304-7	1985	The increase in radiation sensitivity for cells treated with the Rh(II) carboxylates, but not the cis-Pt(II) complexes, is attributed to the ability of the Rh compounds to deplete intracellular thiols.	Sulfhydryl Compounds	194-200	DExD box helicase 50	Mus musculus	65-71
3876304-8	1985	Further, the efficiency of sensitization by the Rh(II) complexes and their ability to interact with cellular thiols depends upon the nature of the carboxylate ligand and follows the order butyrate greater than propionate greater than acetate greater than methoxyacetate.	Sulfhydryl Compounds	109-115	DExD box helicase 50	Mus musculus	48-54
2934089-6	1985	However, it did label GPIb beta in sonicated platelets, indicating that the thiol group of GPIb beta occupies an intracellular location.	Sulfhydryl Compounds	76-81	glycoprotein Ib platelet subunit beta	Homo sapiens	22-31
3840230-9	1985	Each of these regions contains the presumed active site sequence Trp-Cys-Gly-His-Cys-Lys, suggesting that PDI, similar in action to thioredoxin, catalyses disulphide bond interchange via an internal disulphide-sulphydryl interchange.	Sulfhydryl Compounds	210-220	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	106-109
3840230-9	1985	Each of these regions contains the presumed active site sequence Trp-Cys-Gly-His-Cys-Lys, suggesting that PDI, similar in action to thioredoxin, catalyses disulphide bond interchange via an internal disulphide-sulphydryl interchange.	Sulfhydryl Compounds	210-220	thioredoxin 1	Rattus norvegicus	132-143
2993028-1	1985	The effects of microsomal HMG-CoA reductase kinase, cytosolic phosphoprotein phosphatase and cytosolic, thiol-dependent cholesterol 7 alpha-hydroxylase stimulatory protein on purified cholesterol 7 alpha-hydroxylase and HMG-CoA reductase from rat liver were compared.	Sulfhydryl Compounds	104-109	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	120-151
2996495-4	1985	Inhibition studies with p-chloromercuribenzoate and N-ethylmaleimide indicate that ketohexokinase contains thiol groups, which are required for full activity.	Sulfhydryl Compounds	107-112	ketohexokinase	Homo sapiens	83-97
2413243-3	1985	The glucocorticoid receptor protein from humans and other species is a approximately 95,000 d, thiol group-containing monomer, prone to aggregation when "unactivated."	Sulfhydryl Compounds	95-100	nuclear receptor subfamily 3 group C member 1	Homo sapiens	4-27
3874078-11	1985	However, after addition of thiols to the medium, which enhances the IL2 production, a very narrow range of lectin concentration can be found which is just below toxic values and still high enough to induce IL2 production in the absence of accessory cells.	Sulfhydryl Compounds	27-33	interleukin 2	Homo sapiens	68-71
3874078-11	1985	However, after addition of thiols to the medium, which enhances the IL2 production, a very narrow range of lectin concentration can be found which is just below toxic values and still high enough to induce IL2 production in the absence of accessory cells.	Sulfhydryl Compounds	27-33	interleukin 2	Homo sapiens	206-209
3896810-8	1985	The distribution of thioredoxin and thioredoxin reductase is compatible with function in thiol-disulfide interchange reaction related to protein synthesis, intracellular transport and different forms of secretion.	Sulfhydryl Compounds	89-94	thioredoxin 1	Rattus norvegicus	20-31
3896810-8	1985	The distribution of thioredoxin and thioredoxin reductase is compatible with function in thiol-disulfide interchange reaction related to protein synthesis, intracellular transport and different forms of secretion.	Sulfhydryl Compounds	89-94	peroxiredoxin 5	Rattus norvegicus	36-57
2931426-5	1985	I now report the finding that the transformation of 6S-myosin to the 10S conformation results in a drastic change in the reactivity of thiol groups of gizzard myosin with N-iodoacetyl-N"-(5-sulfo-1-naphthyl)ethylenediamine (abbreviated as IAEDANS).	Sulfhydryl Compounds	135-140	myosin, heavy chain 15	Gallus gallus	55-61
2931426-5	1985	I now report the finding that the transformation of 6S-myosin to the 10S conformation results in a drastic change in the reactivity of thiol groups of gizzard myosin with N-iodoacetyl-N"-(5-sulfo-1-naphthyl)ethylenediamine (abbreviated as IAEDANS).	Sulfhydryl Compounds	135-140	myosin, heavy chain 15	Gallus gallus	159-165
2931426-10	1985	The reactivity of the thiol groups with IAEDANS was greatly decreased by the 6S to 10S transformation of gizzard myosin molecules.	Sulfhydryl Compounds	22-27	myosin, heavy chain 15	Gallus gallus	113-119
2931426-12	1985	Blocking the SH1-type thiol groups made the Mg-ATPase activities (in the presence of gizzard native tropomyosin) of gizzard myosin and of acto-gizzard myosin insensitive to calcium and to phosphorylation of regulatory light chains, although calcium-dependent phosphorylation of the IAEDANS-modified myosin could still occur.	Sulfhydryl Compounds	22-27	myosin, heavy chain 15	Gallus gallus	105-111
2931426-12	1985	Blocking the SH1-type thiol groups made the Mg-ATPase activities (in the presence of gizzard native tropomyosin) of gizzard myosin and of acto-gizzard myosin insensitive to calcium and to phosphorylation of regulatory light chains, although calcium-dependent phosphorylation of the IAEDANS-modified myosin could still occur.	Sulfhydryl Compounds	22-27	myosin, heavy chain 15	Gallus gallus	124-130
2931426-12	1985	Blocking the SH1-type thiol groups made the Mg-ATPase activities (in the presence of gizzard native tropomyosin) of gizzard myosin and of acto-gizzard myosin insensitive to calcium and to phosphorylation of regulatory light chains, although calcium-dependent phosphorylation of the IAEDANS-modified myosin could still occur.	Sulfhydryl Compounds	22-27	myosin, heavy chain 15	Gallus gallus	124-130
4044552-1	1985	We have investigated the limited proteolysis of the third component of complement, C3, by a human leukocyte protease, cathepsin G, by using a chemically modified C3, which was prepared by treatment of C3 with methylamine and a fluorescent thiol reagent, N-(dimethylamino-4-methylcoumarinyl)-maleimide (DACM) and was thus named DACM-C3me.	Sulfhydryl Compounds	239-244	cathepsin G	Homo sapiens	118-129
2410017-2	1985	Under experimental conditions where [thrombin] greater than [alpha 2M], the conformational change, measured by increases in the fluorescence of 6-(p-toluidino)-2-naphthalenesulfonate, and thiol group appearance displayed biphasic kinetics.	Sulfhydryl Compounds	188-193	coagulation factor II, thrombin	Homo sapiens	37-45
2410017-2	1985	Under experimental conditions where [thrombin] greater than [alpha 2M], the conformational change, measured by increases in the fluorescence of 6-(p-toluidino)-2-naphthalenesulfonate, and thiol group appearance displayed biphasic kinetics.	Sulfhydryl Compounds	188-193	alpha-2-macroglobulin	Homo sapiens	61-69
2990446-0	1985	Evidence that non-covalent forces, thiol and disulphide groups affect the structure and binding properties of the prolactin receptor on hepatocytes from pregnant rats.	Sulfhydryl Compounds	35-40	prolactin receptor	Rattus norvegicus	114-132
2992663-5	1985	Reaction with membrane-bound sulphydryl (SH) groups by micromolar concentrations of N-ethylmaleimide (NEM), hydroxymercuribenzoic acid (PCMB), or Ellman"s reagent (DTNB) decreased the binding of [3H]-imipramine, the number of 5-HT1-receptors, and the uptake of [3H]-5-HT.	Sulfhydryl Compounds	29-39	dystrobrevin, beta	Rattus norvegicus	164-168
3918853-7	1985	Pretreatment with iodoacetamide resulted in a 33% decrease in maximal PRL values, indicating the presence and functional importance of granule thiols.	Sulfhydryl Compounds	143-149	prolactin	Bos taurus	70-73
2989040-5	1985	The application of different inhibitors suggests that the receptor-mediated degradation of growth hormone in these 2 cell types takes place in an acidified compartment by an energy-requiring process and involving thiol groups.	Sulfhydryl Compounds	213-218	growth hormone 1	Homo sapiens	91-105
21313783-1	1985	Gradual reduction of disulphide bonds in human haptoglobin, type 2-1, was carried out either by the use of sodium borohydride or 2-mercaptoethanol, newly exposed sulphydryl groups as determined by the Ellman"s reagent and by the incorporation of [(14) C] acetamide, respectively.	Sulfhydryl Compounds	162-172	haptoglobin	Homo sapiens	47-58
3987692-11	1985	8-Mercapto-FAD X glutathione reductase, for instance, reacted readily and stoichiometrically with the thiol reagent methylmethanethiosulfonate.	Sulfhydryl Compounds	102-107	glutathione-disulfide reductase	Homo sapiens	17-38
4030750-2	1985	A peptide bridged with a disulfide bond was reduced and cleaved with tributylphosphine, and then coupled with a thiol specific reagent, ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate, under alkaline conditions.	Sulfhydryl Compounds	112-117	OXA1L mitochondrial inner membrane protein	Homo sapiens	161-166
2860337-4	1985	Methionine synthase activity was more thiol-dependent in the patient"s fibroblasts than it was in normal cells.	Sulfhydryl Compounds	38-43	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
2860337-7	1985	Values for incorporation of 14CH3H4PteGlu into methionine by intact cells and the thiol requirement of methionine synthase were abnormal in these amniocytes but these features did not conclusively identify the fetus at risk as being homozygous for the abnormality.	Sulfhydryl Compounds	82-87	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	103-122
3986776-3	1985	Treatment of cells with a carbamoylating nitrosourea, N,N"-bis(trans-4-hydroxycyclohexyl)-N"-nitrosourea, produced a dose-dependent inhibition of glutathione reductase and depletion of thiols in both cell lines.	Sulfhydryl Compounds	185-191	glutathione-disulfide reductase	Rattus norvegicus	146-167
3872340-4	1985	In contrast, the pI 5.1 component of PBM IL-1 is resistant to heat denaturation and sulfhydryl reagents, although it is totally inactivated by phenylglyoxal.	Sulfhydryl Compounds	84-94	interleukin 1 alpha	Homo sapiens	41-45
4048924-0	1985	Changes in circular dichroism and exposure of buried thiol groups during denaturation of rabbit muscle creatine kinase.	Sulfhydryl Compounds	53-58	creatine kinase M-type	Oryctolagus cuniculus	96-118
4004778-5	1985	Cathepsin H was characterized by kinetic analysis of the reactions of its thiol group with 2,2"-dipyridyl disulphide in the pH range approx.	Sulfhydryl Compounds	74-79	cathepsin H	Bos taurus	0-11
4004778-13	1985	This is useful because other active-centre titrations have proved unsuitable in view of the relatively low reactivity of the thiol group in cathepsin H.	Sulfhydryl Compounds	125-130	cathepsin H	Bos taurus	140-151
4002199-2	1985	The inhibitions of aggregation of platelet-rich plasma (PRP) and washed platelets, and of malondialdehyde production in thrombin-stimulated platelets by KF4939 were counteracted by pretreatment with sulfhydryl compounds, glutathione, 1-cysteine and dithiothreitol.	Sulfhydryl Compounds	199-219	prothrombin	Oryctolagus cuniculus	120-128
3983914-0	1985	FXIII induced gelation of human fibrinogen--an alternative thiol enhanced, thrombin independent pathway.	Sulfhydryl Compounds	59-64	fibrinogen beta chain	Homo sapiens	32-42
3158880-3	1985	Drug activation and the consequent hydrogen abstraction reaction, presumably generating a carbon-centered radical at C-5", do not require molecular oxygen but have a dose-dependent relation with thiol.	Sulfhydryl Compounds	195-200	complement C5	Homo sapiens	117-120
3994671-0	1985	Hepatic thiol and glutathione efflux under the influence of vasopressin, phenylephrine and adrenaline.	Sulfhydryl Compounds	8-13	arginine vasopressin	Rattus norvegicus	60-71
3994671-1	1985	Thiol and glutathione (GSH) efflux across the sinusoidal plasma membrane in isolated perfused rat liver was stimulated by addition of hormones such as vasopressin, phenylephrine and adrenaline, whereas glucagon or dibutyryl cyclic AMP were without effect.	Sulfhydryl Compounds	0-5	arginine vasopressin	Rattus norvegicus	151-162
2857177-1	1985	The effect of thiol oxidants on the light-activated H+-ATPase has been studied in freshly broken and intact chloroplasts.	Sulfhydryl Compounds	14-19	dynein axonemal heavy chain 8	Homo sapiens	55-61
2857177-0	1985	Differential effect of thiol oxidants on the chloroplast H+-ATPase in the light and in the dark.	Sulfhydryl Compounds	23-28	dynein axonemal heavy chain 8	Homo sapiens	60-66
4096891-5	1985	The data indicate that the superreactivity of intersubunit disulfides of seminal ribonuclease is matched by the high reactivity at neutral pH of adjacent cysteine residues 31 and 32, as compared to all small thiol compounds tested.	Sulfhydryl Compounds	208-213	seminal ribonuclease	Bos taurus	73-93
4096891-7	1985	These data, and the other results reported in this paper, led to the conclusion that the superreactivity at neutral pH of cysteine residues at positions 31 and 32 of bovine seminal ribonuclease is primarily dependent on the nearby presence of positively charged groups, particularly the epsilon-NH2 of lysine-34, and is influenced by the adjacency of the two thiols and by the protein tertiary structure.	Sulfhydryl Compounds	359-365	seminal ribonuclease	Bos taurus	173-193
2981675-10	1985	Thiol-blocking agents selectively prevented the appearance of the larger component (hCG coupled to 64,000 mol wt receptor fragment), while metal-chelating agents markedly decreased the appearance of the smaller component (hCG coupled to 38,000 mol wt receptor fragment) in the medium.	Sulfhydryl Compounds	0-5	chorionic gonadotropin subunit beta 5	Homo sapiens	84-87
3155516-0	1985	Modification of thiols of gizzard myosin alters ATPase activity, stability of myosin filaments, and the 6-10 S conformational transition.	Sulfhydryl Compounds	16-22	myosin heavy chain 14	Homo sapiens	34-40
3844938-4	1985	Addition of oxidized glutathione to mixtures containing either reduced thiol gave a new product of molecular weight intermediate between the high molecular weight product and Fab- and Fc-like fragments.	Sulfhydryl Compounds	71-76	FA complementation group B	Homo sapiens	175-178
3155516-0	1985	Modification of thiols of gizzard myosin alters ATPase activity, stability of myosin filaments, and the 6-10 S conformational transition.	Sulfhydryl Compounds	16-22	dynein axonemal heavy chain 8	Homo sapiens	48-54
3155516-0	1985	Modification of thiols of gizzard myosin alters ATPase activity, stability of myosin filaments, and the 6-10 S conformational transition.	Sulfhydryl Compounds	16-22	myosin heavy chain 14	Homo sapiens	78-84
3155516-1	1985	The pattern of incorporation of [14C]N-ethylmaleimide (MalNEt) into gizzard myosin indicates the presence of two classes of thiols: rapidly and slowly modified.	Sulfhydryl Compounds	124-130	myosin heavy chain 14	Homo sapiens	76-82
3155516-2	1985	The first class contains two thiol residues, SH-A and SH-B, located in the myosin rod and the 17-kDa light chain, respectively, while the second contains at least two thiols located in the myosin heavy chain.	Sulfhydryl Compounds	29-34	myosin heavy chain 14	Homo sapiens	75-81
3155516-3	1985	Changes in ATPase activities upon modification occur rapidly or slowly, paralleling reaction of either the first or second class of thiols.	Sulfhydryl Compounds	132-138	dynein axonemal heavy chain 8	Homo sapiens	11-17
3155516-8	1985	Modification of the second class of thiols is accompanied by a decrease in K+-EDTA-activated activity and an increase in Ca2+-activated activity measured above 0.3 M NaCl, where myosin neither forms filaments nor assumes the 10 S conformation.	Sulfhydryl Compounds	36-42	myosin heavy chain 14	Homo sapiens	178-184
3155516-9	1985	These slow changes are characteristic of blocking the SH-1 thiols of skeletal-muscle myosin, but in gizzard myosin are attributable to modification of a less reactive thiol, SH-C.	Sulfhydryl Compounds	59-65	myosin heavy chain 14	Homo sapiens	85-91
3155516-9	1985	These slow changes are characteristic of blocking the SH-1 thiols of skeletal-muscle myosin, but in gizzard myosin are attributable to modification of a less reactive thiol, SH-C.	Sulfhydryl Compounds	59-64	myosin heavy chain 14	Homo sapiens	85-91
2999224-9	1985	These receptor alterations may be attributed to a disuse and/or a partial degeneration of nerve terminals due to peripheral neurotoxins (i.e., ammonia, mercaptans, short chain fatty acids) and the decrease of glutamate decarboxylase activity and of zinc levels in brain tissues seems to be respectively a direct and an indirect demonstration of this phenomenon.	Sulfhydryl Compounds	152-162	glutamate-ammonia ligase	Rattus norvegicus	209-232
3977821-0	1985	The thiol groups of mouse immunoglobulin A.	Sulfhydryl Compounds	4-9	immunoglobulin heavy constant alpha	Mus musculus	26-42
3977821-6	1985	This residue may allow attachment of secretory component to dimer IgA in the mouse to proceed via thiol-disulphide exchange.	Sulfhydryl Compounds	98-103	immunoglobulin heavy constant alpha	Mus musculus	66-69
3873575-2	1985	The active fraction also had a sulfhydryl-containing moiety, the concentration of which was correlated directly with the extent of inhibition of the LPO enzyme.	Sulfhydryl Compounds	31-41	lactoperoxidase	Canis lupus familiaris	149-152
3155814-1	1985	The relationship between thiol depletion and its enhancement of melphalan (L-PAM) cytotoxicity was studied with the use of V-79-379A Chinese hamster cells in vitro.	Sulfhydryl Compounds	25-30	peptidyl-glycine alpha-amidating monooxygenase	Cricetulus griseus	77-80
3155814-5	1985	Cellular loss of nonprotein thiols by treatment with BSO correlated with enhanced L-PAM toxicity; however, a far greater effect was achieved when this enzymatic inhibitor was used in combination with a hypoxic cell sensitizer.	Sulfhydryl Compounds	28-34	peptidyl-glycine alpha-amidating monooxygenase	Cricetulus griseus	84-87
2995938-5	1985	Thiol reagents reduced receptor binding activity, suggesting that an intrachain disulfide bond might be an important constituent of the VIP binding site.	Sulfhydryl Compounds	0-5	vasoactive intestinal peptide	Rattus norvegicus	136-139
4088542-1	1985	The metabolism of CS2 proceeds by two distinct metabolic pathways, direct reaction with amine or thiol functions of cellular constituents, and microsomal oxidation to reactive intermediates that covalently bind to cell macromolecules.	Sulfhydryl Compounds	97-102	chorionic somatomammotropin hormone 2	Homo sapiens	18-21
6526379-9	1984	We found that the free thiol group, localized at position 121 or in equal amounts at positions 119 and 121 in bovine beta-lactoglobulin, is absent in beta-lactoglobulin I from horse colostrum.	Sulfhydryl Compounds	23-28	beta-lactoglobulin	Bos taurus	117-135
6096141-4	1984	The binding site for 125I-NPY was sensitive to treatment with proteolytic enzymes and thiol reagents.	Sulfhydryl Compounds	86-91	neuropeptide Y	Rattus norvegicus	26-29
6395896-3	1984	Heavy atom effects observed in the CH3Hg(II)-sulfhydryl complex of pig GAPD resemble closely those reported earlier for the analogous rabbit GAPD-CH3Hg(II) complex.	Sulfhydryl Compounds	45-55	glyceraldehyde-3-phosphate dehydrogenase	Sus scrofa	71-75
6395896-3	1984	Heavy atom effects observed in the CH3Hg(II)-sulfhydryl complex of pig GAPD resemble closely those reported earlier for the analogous rabbit GAPD-CH3Hg(II) complex.	Sulfhydryl Compounds	45-55	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	141-145
6085009-2	1984	The time course of the interactions of alpha 2-macroglobulin with trypsin and with plasmin was studied by measuring the generation of thiol groups, the concentration of alpha 2-macroglobulin subunits cleaved at the bait regions, and the change in intrinsic protein fluorescence of alpha 2-macroglobulin-enzyme reaction mixtures as functions of time.	Sulfhydryl Compounds	134-139	alpha-2-macroglobulin	Homo sapiens	39-60
6085009-2	1984	The time course of the interactions of alpha 2-macroglobulin with trypsin and with plasmin was studied by measuring the generation of thiol groups, the concentration of alpha 2-macroglobulin subunits cleaved at the bait regions, and the change in intrinsic protein fluorescence of alpha 2-macroglobulin-enzyme reaction mixtures as functions of time.	Sulfhydryl Compounds	134-139	plasminogen	Homo sapiens	83-90
6085009-6	1984	At low proteinase activity no further bait region cleavages occur and only the two thiol groups of half of the alpha 2-macroglobulin molecule are generated in the final 1:1 complex.	Sulfhydryl Compounds	83-88	alpha-2-macroglobulin	Homo sapiens	111-132
6501297-2	1984	The resonance Raman spectrum of CH3OC(=O)-Phe-NHCH2C(=S)S-cathepsin B, where the thiol S is from the active-site cysteine residue, is compared to that of the corresponding papain acyl-enzyme.	Sulfhydryl Compounds	81-86	cathepsin B	Homo sapiens	58-69
6526379-9	1984	We found that the free thiol group, localized at position 121 or in equal amounts at positions 119 and 121 in bovine beta-lactoglobulin, is absent in beta-lactoglobulin I from horse colostrum.	Sulfhydryl Compounds	23-28	beta-lactoglobulin	Bos taurus	150-168
6479100-10	1984	The regulation of thiol:disulfide equilibria appears to be an important determinant of the detectability of PRL storage forms and of their secretion.	Sulfhydryl Compounds	18-23	prolactin	Bos taurus	108-111
6149726-7	1984	The alkylation of the thiol groups by N-ethylmaleimide or N-iodoacetyl-N-(5-sulfo-1-naphtyl)ethylenediamine, and the trinitrophenylation of the lysyl residues by 2,4,6-trinitrobenzenesulfonate caused a significant decrease in the K+(EDTA)-dependent ATPase activity of the two myosins.	Sulfhydryl Compounds	22-27	dynein axonemal heavy chain 8	Homo sapiens	249-255
6093188-10	1984	Catalase also reduces the oxygen uptake for all thiols.	Sulfhydryl Compounds	48-54	catalase	Homo sapiens	0-8
6437445-0	1984	Formation of a stable complex of thrombin and the secreted platelet protein glycoprotein G (thrombin-sensitive protein, thrombospondin) by thiol-disulfide exchange.	Sulfhydryl Compounds	139-144	coagulation factor II, thrombin	Homo sapiens	33-41
6437445-0	1984	Formation of a stable complex of thrombin and the secreted platelet protein glycoprotein G (thrombin-sensitive protein, thrombospondin) by thiol-disulfide exchange.	Sulfhydryl Compounds	139-144	coagulation factor II, thrombin	Homo sapiens	92-100
6095975-5	1984	Inhibition and spectral shifts induced by some thiol compounds were very similar to those reported with mammalian catalase.	Sulfhydryl Compounds	47-52	catalase	Homo sapiens	114-122
6209394-3	1984	At the thiol group, DM-linked PLGA was bound to horse anti-rat alpha-fetoprotein (AFP) antibody.	Sulfhydryl Compounds	7-12	alpha-fetoprotein	Rattus norvegicus	63-80
6209394-3	1984	At the thiol group, DM-linked PLGA was bound to horse anti-rat alpha-fetoprotein (AFP) antibody.	Sulfhydryl Compounds	7-12	alpha-fetoprotein	Rattus norvegicus	82-85
6541651-3	1984	To help clarify this problem, we have carried out extensive studies of thiol-binding properties of native ferric chloroperoxidase and have compared our new results with those previously obtained in our laboratory on thiol adducts of P-450.	Sulfhydryl Compounds	216-221	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	233-238
6541651-4	1984	We have found that the ligation of exogenous thiols to the heme iron of chloroperoxidase generates hyperporphyrin (split Soret) spectra (lambda max = approximately 372 and approximately 455 nm), consistent with the formation of bisthiolate low-spin ferric heme adducts as has been established for P-450 and its heme models.	Sulfhydryl Compounds	45-51	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	297-302
6435914-5	1984	Serum CK-BB may be a useful tumor marker if reactivation with a thiol and EDTA is used immediately after collection.	Sulfhydryl Compounds	64-69	creatine kinase B	Homo sapiens	6-11
6437445-11	1984	It is concluded that glycoprotein G (thrombin-sensitive protein, thrombospondin) and thrombin form a dissociable complex that leads to a covalent complex by thiol-disulfide exchange of a thiol group on glycoprotein G and a disulfide on thrombin.	Sulfhydryl Compounds	157-162	coagulation factor II, thrombin	Homo sapiens	37-45
6437445-11	1984	It is concluded that glycoprotein G (thrombin-sensitive protein, thrombospondin) and thrombin form a dissociable complex that leads to a covalent complex by thiol-disulfide exchange of a thiol group on glycoprotein G and a disulfide on thrombin.	Sulfhydryl Compounds	157-162	coagulation factor II, thrombin	Homo sapiens	85-93
6437445-11	1984	It is concluded that glycoprotein G (thrombin-sensitive protein, thrombospondin) and thrombin form a dissociable complex that leads to a covalent complex by thiol-disulfide exchange of a thiol group on glycoprotein G and a disulfide on thrombin.	Sulfhydryl Compounds	157-162	coagulation factor II, thrombin	Homo sapiens	85-93
6437445-11	1984	It is concluded that glycoprotein G (thrombin-sensitive protein, thrombospondin) and thrombin form a dissociable complex that leads to a covalent complex by thiol-disulfide exchange of a thiol group on glycoprotein G and a disulfide on thrombin.	Sulfhydryl Compounds	187-192	coagulation factor II, thrombin	Homo sapiens	37-45
6437445-11	1984	It is concluded that glycoprotein G (thrombin-sensitive protein, thrombospondin) and thrombin form a dissociable complex that leads to a covalent complex by thiol-disulfide exchange of a thiol group on glycoprotein G and a disulfide on thrombin.	Sulfhydryl Compounds	187-192	coagulation factor II, thrombin	Homo sapiens	85-93
6437445-11	1984	It is concluded that glycoprotein G (thrombin-sensitive protein, thrombospondin) and thrombin form a dissociable complex that leads to a covalent complex by thiol-disulfide exchange of a thiol group on glycoprotein G and a disulfide on thrombin.	Sulfhydryl Compounds	187-192	coagulation factor II, thrombin	Homo sapiens	85-93
6388564-8	1984	Sodium dodecyl sulphate/polyacrylamide-gel electrophoresis of complexes formed between papain or cathepsin B and an excess of cystatin showed no peptide bond cleavage after incubation for 72 h. The reaction of the active-site thiol group of papain with 5,5"-dithiobis-(2-nitrobenzoic acid) at pH 8 and 2,2"-dithiobispyridine at pH 4 was blocked by complex-formation.	Sulfhydryl Compounds	226-231	cathepsin B	Homo sapiens	97-108
6097584-2	1984	The electron spin resonance spectra of the spin label bound to myosin head showed temperature-dependent changes indicating changes of the structure around the SH1 thiol group of the myosin head.	Sulfhydryl Compounds	163-168	myosin heavy chain 14	Homo sapiens	63-69
6097584-2	1984	The electron spin resonance spectra of the spin label bound to myosin head showed temperature-dependent changes indicating changes of the structure around the SH1 thiol group of the myosin head.	Sulfhydryl Compounds	163-168	myosin heavy chain 14	Homo sapiens	182-188
6508858-2	1984	With the aid of thiol-disulfide exchange chromatography and SDS polyacrylamide gel electrophoresis the F1 and F2 fragments of the modified cytochrome P-450 were isolated.	Sulfhydryl Compounds	16-21	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	139-155
6534384-1	1984	pH-dependent kinetics of the reactions of cathepsin B from bovine spleen and from rat liver with a thiol-specific two-protonic-state probe (2,2"-dipyridyl disulphide) and with a specific synthetic substrate (N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide).	Sulfhydryl Compounds	99-104	cathepsin B	Bos taurus	42-53
6534384-2	1984	Cathepsin B (EC 3.4.22.1) from bovine spleen and the analogous enzyme from rat liver were investigated at 25 degrees C at I0.1 in acidic media by kinetic study of (a) the reactions of their catalytic-site thiol groups towards the two-protonic-state reactivity probe 2,2"-dipyridyl disulphide and (b) their catalysis of the hydrolysis of N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide.	Sulfhydryl Compounds	205-210	cathepsin B	Bos taurus	0-11
6548525-0	1984	Electron microscopic visualization of the SH1 thiol of myosin by the use of an avidin-biotin system.	Sulfhydryl Compounds	46-51	myosin heavy chain 14	Homo sapiens	55-61
6548525-1	1984	One of the reactive thiols in the myosin head, SH1, was covalently labeled with a biotin derivative, N-iodoacetyl-N"-biotinylhexylenediamine.	Sulfhydryl Compounds	20-26	myosin heavy chain 14	Homo sapiens	34-40
6548525-2	1984	When 50% of the SH1 thiol was modified with the biotin reagent as judged from measurements of ATPase activities, the biotinylated myosin bound one mole of avidin per mole of myosin at the saturating level.	Sulfhydryl Compounds	20-25	myosin heavy chain 14	Homo sapiens	130-136
6548525-2	1984	When 50% of the SH1 thiol was modified with the biotin reagent as judged from measurements of ATPase activities, the biotinylated myosin bound one mole of avidin per mole of myosin at the saturating level.	Sulfhydryl Compounds	20-25	myosin heavy chain 14	Homo sapiens	174-180
6548525-5	1984	Electron microscopic examination of the avidin-myosin complex showed that the attachment site of avidin on the myosin head is 130 A from the head-rod junction, indicating that the SH1 thiol is located there.	Sulfhydryl Compounds	184-189	myosin heavy chain 14	Homo sapiens	47-53
6548525-5	1984	Electron microscopic examination of the avidin-myosin complex showed that the attachment site of avidin on the myosin head is 130 A from the head-rod junction, indicating that the SH1 thiol is located there.	Sulfhydryl Compounds	184-189	myosin heavy chain 14	Homo sapiens	111-117
6547856-2	1984	Chymotrypsin and papain digestion of 3H-labelled dinitrophenylated chicken gizzard myosin, pretreated with the myosin light chain catalyzed phosphorylating system, released a subfragment 1 devoid of its light chains but containing all of the label associated with the thiols of the heavy chain region.	Sulfhydryl Compounds	268-274	myosin, heavy chain 15	Gallus gallus	83-89
6430683-6	1984	Thiols such as mercaptoethanol, cysteine, glutathione, and others without nearby amino groups were stimulators of PRL assayability and release.	Sulfhydryl Compounds	0-6	prolactin	Homo sapiens	114-117
6430683-11	1984	We conclude that the inhibitory aminothiol action on PRL requires the thiol rather than the sulfide form and involves a reversible interaction which diminishes the immunochemical recognition of granule PRL.	Sulfhydryl Compounds	37-42	prolactin	Homo sapiens	53-56
6430683-11	1984	We conclude that the inhibitory aminothiol action on PRL requires the thiol rather than the sulfide form and involves a reversible interaction which diminishes the immunochemical recognition of granule PRL.	Sulfhydryl Compounds	37-42	prolactin	Homo sapiens	202-205
24458697-0	1984	Involvement of thiol groups in the activity of phosphoenolpyruvate carboxylase from maize leaves.	Sulfhydryl Compounds	15-20	MLO-like protein 4	Zea mays	47-78
24458697-1	1984	Purified maize leaf phosphoenolpyruvate carboxylase (EC 4.1.1.31) was completely inactivated by several thiol-modifying reagents, including, CuCl2, CdCl2 and N-ethylmaleimide.	Sulfhydryl Compounds	104-109	MLO-like protein 4	Zea mays	20-51
6547856-2	1984	Chymotrypsin and papain digestion of 3H-labelled dinitrophenylated chicken gizzard myosin, pretreated with the myosin light chain catalyzed phosphorylating system, released a subfragment 1 devoid of its light chains but containing all of the label associated with the thiols of the heavy chain region.	Sulfhydryl Compounds	268-274	myosin, heavy chain 15	Gallus gallus	111-117
6745176-11	1984	Depletion of PRL might involve interference with the conversion from oligomeric storage PRL to assayable PRL; 44-fold increases in PRL oligomer immunoactivity after alkali and thiol treatment were reduced to 6-fold increases when CySH was present.	Sulfhydryl Compounds	176-181	prolactin	Bos taurus	13-16
6745176-11	1984	Depletion of PRL might involve interference with the conversion from oligomeric storage PRL to assayable PRL; 44-fold increases in PRL oligomer immunoactivity after alkali and thiol treatment were reduced to 6-fold increases when CySH was present.	Sulfhydryl Compounds	176-181	prolactin	Bos taurus	88-91
6468376-3	1984	For locating the interacting thiols within the polypeptide chains the dissociated proteins L6 and L29 obtained from the isolated disulfide complex were subjected to S-cleavage following [14C]cyanylation of the two cysteine residues.	Sulfhydryl Compounds	29-35	ribosomal protein L29	Homo sapiens	98-101
6745176-11	1984	Depletion of PRL might involve interference with the conversion from oligomeric storage PRL to assayable PRL; 44-fold increases in PRL oligomer immunoactivity after alkali and thiol treatment were reduced to 6-fold increases when CySH was present.	Sulfhydryl Compounds	176-181	prolactin	Bos taurus	88-91
6745176-11	1984	Depletion of PRL might involve interference with the conversion from oligomeric storage PRL to assayable PRL; 44-fold increases in PRL oligomer immunoactivity after alkali and thiol treatment were reduced to 6-fold increases when CySH was present.	Sulfhydryl Compounds	176-181	prolactin	Bos taurus	88-91
16663773-0	1984	On the molecular mechanism of maize phosphoenolpyruvate carboxylase activation by thiol compounds.	Sulfhydryl Compounds	82-87	MLO-like protein 4	Zea mays	36-67
6429185-5	1984	These data indicate that both leukocyte fractions contain thiol-dependent insulin-degrading activity; however, only in the MN fraction was the degrading activity immunologically similar to that of liver GIT.	Sulfhydryl Compounds	58-63	insulin	Homo sapiens	74-81
16663773-3	1984	The activation induced by dithiothreitol was reversed by diamide, an oxidant of vicinal dithiols, suggesting that the redox state of disulfide bonds of the enzyme may be important in the expression of the maximal catalytic activity.Titration of thiol groups before and after activation of maize phosphoenolpyruvate carboxylase by dithiothreitol shows an increase of the accessible groups from 8 to 12 suggesting that the reduction of two disulfide bonds accompanied the activation.	Sulfhydryl Compounds	90-95	MLO-like protein 4	Zea mays	295-326
6424572-11	1984	The enzyme was inhibited by Zn2+, Fe2+, Hg2+, and sulfhydryl blockers such as 5,5"-dithiobis(2-nitrobenzoic acid), p-hydroxymercuribenzoate, and iodoacetate, apparently due to their reaction with one out of six titratable sulfhydryl groups per mole of acrosin.	Sulfhydryl Compounds	50-60	acrosin	Oryctolagus cuniculus	252-259
6235126-4	1984	The activation by Cd2+ of MLCK was inhibited by anticalmodulins (e.g., R-24571), whereas the inhibition by a higher Cd2+ concentration of MLCK and PL-Ca-PK was reversed by thiol agents (e.g., cysteine).	Sulfhydryl Compounds	172-177	Cd2 molecule	Rattus norvegicus	18-21
6235126-4	1984	The activation by Cd2+ of MLCK was inhibited by anticalmodulins (e.g., R-24571), whereas the inhibition by a higher Cd2+ concentration of MLCK and PL-Ca-PK was reversed by thiol agents (e.g., cysteine).	Sulfhydryl Compounds	172-177	myosin light chain kinase	Rattus norvegicus	26-30
6235217-1	1984	Forster energy transfer distance measurements from trapped 1,N6-ethenoadenosine diphosphate to chromophoric cross-linking reagents on the critical thiols of myosin subfragment.	Sulfhydryl Compounds	147-153	myosin heavy chain 14	Homo sapiens	157-163
6327455-3	1984	Proteinase activity was inhibited by serum fractions, thiol reagents, heavy metals, leupeptin, and antipain.	Sulfhydryl Compounds	54-59	endogenous retrovirus group K member 25	Homo sapiens	0-10
6327455-13	1984	The major cell rounding cytotoxic activity of E. histolytica extracts in vitro is probably due to the activity of a thiol-containing cathepsin B-like proteinase.	Sulfhydryl Compounds	116-121	endogenous retrovirus group K member 25	Homo sapiens	150-160
6547966-13	1984	These lifetimes were used to quantify changes in distances between two activity-related thiols on myosin upon the addition of Mg-ATP or its analogs.	Sulfhydryl Compounds	88-94	myosin heavy chain 14	Homo sapiens	98-104
6329286-8	1984	125I-VIP binding was, indeed, reduced after dithiothreitol preincubation, low concentrations of the thiol reagent decreasing the apparent number of high-affinity VIP receptors and higher dithiothreitol concentrations reducing the affinity of VIP receptors.	Sulfhydryl Compounds	100-105	vasoactive intestinal peptide	Rattus norvegicus	5-8
6329286-8	1984	125I-VIP binding was, indeed, reduced after dithiothreitol preincubation, low concentrations of the thiol reagent decreasing the apparent number of high-affinity VIP receptors and higher dithiothreitol concentrations reducing the affinity of VIP receptors.	Sulfhydryl Compounds	100-105	vasoactive intestinal peptide	Rattus norvegicus	162-165
6329286-8	1984	125I-VIP binding was, indeed, reduced after dithiothreitol preincubation, low concentrations of the thiol reagent decreasing the apparent number of high-affinity VIP receptors and higher dithiothreitol concentrations reducing the affinity of VIP receptors.	Sulfhydryl Compounds	100-105	vasoactive intestinal peptide	Rattus norvegicus	162-165
6725253-6	1984	C3-1 retains, on its alpha-chain, a unique hidden thiol site that can be exposed upon attachment of methylamine in the same way as human C3 and C4.	Sulfhydryl Compounds	50-55	c3-1	Oncorhynchus mykiss	0-4
6725253-6	1984	C3-1 retains, on its alpha-chain, a unique hidden thiol site that can be exposed upon attachment of methylamine in the same way as human C3 and C4.	Sulfhydryl Compounds	50-55	Fc gamma receptor and transporter	Homo sapiens	21-32
6238023-2	1984	Thiols of myosin.	Sulfhydryl Compounds	0-6	myosin heavy chain 14	Homo sapiens	10-16
6238023-3	1984	Myosin has 2 mol of the most reactive thiol, named SH1.	Sulfhydryl Compounds	38-43	myosin heavy chain 14	Homo sapiens	0-6
6233280-4	1984	Sulfhydryl residues exposed during activation can be reoxidized to disulfide by incubation with iodosobenzoate , with a concomitant loss of ATPase activity.	Sulfhydryl Compounds	0-10	dynein axonemal heavy chain 8	Homo sapiens	140-146
6327912-2	1984	Neurotensin degradation by rabbit brain cystosol fractions was activated by dithiothreitol and inhibited by thiol blocking reagents, Zn2+, and by monospecific antibodies against endo- oligopeptidases A and B, thus suggesting the possible involvement of these enzymes in neurotensin degradation by rabbit brain.	Sulfhydryl Compounds	108-113	neurotensin/neuromedin N	Oryctolagus cuniculus	0-11
6464517-3	1984	Investigations on glucose-6-phosphate-dehydrogenase-deficient platelets and on the effect of glutathione-oxidizing substances on normal platelets showed references to a regulatory significance of the cellular thiol/disulphide state in the process of activation.	Sulfhydryl Compounds	209-214	glucose-6-phosphate dehydrogenase	Homo sapiens	18-51
6715334-2	1984	A stable, reversibly sulfhydryl-modified, Zn2+-free porphobilinogen synthase (mod-apo-PBG synthase) has been prepared using methylmethanethiosulfonate.	Sulfhydryl Compounds	21-31	aminolevulinate dehydratase	Homo sapiens	52-76
6326144-11	1984	Thus, the secretory granule carboxypeptidase B-like activities in all three lobes of the pituitary appear to be similar thiol-metallopeptidases that differ from other carboxypeptidase activities previously described and may play an exclusive role in hormone biosynthesis in the pituitary.	Sulfhydryl Compounds	120-125	carboxypeptidase B1	Rattus norvegicus	28-46
6425288-5	1984	In contrast to the wild type enzyme, thiol beta-lactamase contains one free titratable thiol group/molecule.	Sulfhydryl Compounds	37-42	beta-lactamase	Escherichia coli	43-57
6424998-3	1984	Since thrombin is a serine esterase phylogenetically related to the serine esterases elastase and cathepsin G, the most likely mechanism of action is an interaction of the gold thiol complex with one or all of the four cysteine-cysteine disulfide bridges of the thrombin molecule.	Sulfhydryl Compounds	177-182	coagulation factor II, thrombin	Homo sapiens	6-14
6424998-3	1984	Since thrombin is a serine esterase phylogenetically related to the serine esterases elastase and cathepsin G, the most likely mechanism of action is an interaction of the gold thiol complex with one or all of the four cysteine-cysteine disulfide bridges of the thrombin molecule.	Sulfhydryl Compounds	177-182	cathepsin G	Homo sapiens	98-109
6424998-3	1984	Since thrombin is a serine esterase phylogenetically related to the serine esterases elastase and cathepsin G, the most likely mechanism of action is an interaction of the gold thiol complex with one or all of the four cysteine-cysteine disulfide bridges of the thrombin molecule.	Sulfhydryl Compounds	177-182	coagulation factor II, thrombin	Homo sapiens	262-270
6722114-3	1984	In the absence of ATP, G-actin exposed four thiol groups ( G4s ).	Sulfhydryl Compounds	44-49	arylsulfatase B	Homo sapiens	59-62
6722114-7	1984	This must be concluded from the fact that the shielding effect of thiol groups induced by addition of ATP was lost within ca.	Sulfhydryl Compounds	66-71	ATPase phospholipid transporting 8A2	Homo sapiens	102-105
6231955-3	1984	Affinity of toxin sites for agonists is altered by specific sulfhydryl/disulfide modification and by Ca2+, and sites may be labeled with the nicotinic acetylcholine receptor affinity reagent bromoacetylcholine.	Sulfhydryl Compounds	60-70	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	141-173
6373594-6	1984	In contrast to a marked (10-fold) increase of latent renin by dithiothreitol, the enzyme activity of active renin was increased by less than 50% by this sulfhydryl compound.	Sulfhydryl Compounds	153-163	renin	Rattus norvegicus	108-113
6713598-4	1984	Bovine serum albumin (BSA), which contains a single free sulfhydryl group per molecule and which thus represents a macromolecular thiol compound, inhibited covalent binding of the reactive acetaminophen metabolite to microsomal protein in a concentration-dependent manner.	Sulfhydryl Compounds	130-135	albumin	Mus musculus	7-20
6713598-4	1984	Bovine serum albumin (BSA), which contains a single free sulfhydryl group per molecule and which thus represents a macromolecular thiol compound, inhibited covalent binding of the reactive acetaminophen metabolite to microsomal protein in a concentration-dependent manner.	Sulfhydryl Compounds	130-135	albumin	Bos taurus	22-25
6713598-6	1984	47% when the thiol function of BSA was selectively blocked prior to incubation.	Sulfhydryl Compounds	13-18	albumin	Bos taurus	31-34
6698990-1	1984	The role of sulfhydryl groups in the activity of the terminal enzyme of the heme biosynthetic pathway, ferrochelatase (protoheme ferrolyase, EC 4.99.1.1), has been examined by using a variety of sulfhydryl group-specific reagents.	Sulfhydryl Compounds	12-22	FECH	Bos taurus	103-117
6528814-5	1984	It was concluded that the inhibitory effects of some heavy metal salts on MAO activity were not directly connected with their action on enzyme thiol groups but more probably with changes in the enzyme membrane surroundings in the different organs.	Sulfhydryl Compounds	143-148	monoamine oxidase A	Rattus norvegicus	74-77
6360667-6	1984	The increase in thiol enzyme activity was attributed both to cathepsin B and to the other thiol endopeptidases.	Sulfhydryl Compounds	16-21	cathepsin B	Oryctolagus cuniculus	61-72
6199017-3	1984	Exhaustive thiol reduction, however, almost abolished antigenicity, caused breakdown of the mucin into small heterogeneous glycopeptides, and liberated a "link" peptide of Mr 118000.	Sulfhydryl Compounds	11-16	LOC100508689	Homo sapiens	92-97
6477598-3	1984	Besides, the thiol markedly increased not only the Km value for aminopyrine N-demethylase but also the apparent Ks value for aminopyrine binding to the microsomal oxidized cytochrome P-450 by interacting with the cytochrome P-450.	Sulfhydryl Compounds	13-18	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	172-188
6477598-3	1984	Besides, the thiol markedly increased not only the Km value for aminopyrine N-demethylase but also the apparent Ks value for aminopyrine binding to the microsomal oxidized cytochrome P-450 by interacting with the cytochrome P-450.	Sulfhydryl Compounds	13-18	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	213-229
6324613-2	1984	The free thiol is a mucolytic compound which acts via the reduction of disulfide bonds of mucin molecules.	Sulfhydryl Compounds	9-14	LOC100508689	Homo sapiens	90-95
6320805-7	1984	The dye appears to act as an affinity label for the ATP/ADP-binding site by preferentially arylating a thiol residue generated during the reductive activation of the enzyme that is achieved by dithiothreitol or thioredoxin in vitro or during illumination of leaves.	Sulfhydryl Compounds	103-108	LOC101027257	Zea mays	211-222
6323860-3	1984	This new receptor assay method was used to study the modulation of androgen receptor of rat ventral prostate by metal ions, thiols, and ligand structure.	Sulfhydryl Compounds	124-130	androgen receptor	Rattus norvegicus	67-84
6083952-1	1984	It was found that the thiol-oxidizing agent diamide inhibits the formation of arachidonic acid metabolites in thrombin-stimulated platelets.	Sulfhydryl Compounds	22-27	coagulation factor II, thrombin	Homo sapiens	110-118
6714935-4	1984	Aminopeptidase 1 appeared to be a strongly sulfhydryl-dependent leucine aminopeptidase, activatable by thiol reagents.	Sulfhydryl Compounds	103-108	carboxypeptidase Q	Homo sapiens	0-14
6714935-4	1984	Aminopeptidase 1 appeared to be a strongly sulfhydryl-dependent leucine aminopeptidase, activatable by thiol reagents.	Sulfhydryl Compounds	103-108	carboxypeptidase Q	Homo sapiens	72-86
6229604-8	1984	It is suggested that even though intracellular accumulation of CuL+ creates an oxidizing environment and is potentially capable of inhibiting thiol enzymes such as hexokinase, protective effects are exerted in the red cell by the presence of hemoglobin, of radical scavengers, and of high levels of enzymes that detoxify toxic oxygen species.	Sulfhydryl Compounds	142-147	hexokinase	Saccharomyces cerevisiae S288C	164-174
6544185-2	1984	This partially denatured C3 (C3i) was coupled to activated Thiol-Sepharose via its single SH group.	Sulfhydryl Compounds	59-64	complement C3	Homo sapiens	25-27
6544185-2	1984	This partially denatured C3 (C3i) was coupled to activated Thiol-Sepharose via its single SH group.	Sulfhydryl Compounds	59-64	complement C3	Homo sapiens	29-32
6544185-4	1984	C3i was also fixed to sheep red cells which had been supplied with activated thiol groups by treatment with N-succinimidyl-3-(2-pyridyldithio)-propionate.	Sulfhydryl Compounds	77-82	complement C3	Homo sapiens	0-3
6198647-7	1984	The 125I-PDGF-alpha 2M complex or 125I-PDGF-plasma binding protein complex was not dissociated by 8 M urea, 1 M acetic acid, 0.1 M NaOH, or 1% NaDodSO4 but was dissociated by 2-mercaptoethanol, suggesting that the covalent binding of 125I-PDGF to alpha 2M occurs through a disulfide/sulfhydryl exchange reaction.	Sulfhydryl Compounds	283-293	alpha-2-macroglobulin	Homo sapiens	14-22
6504215-2	1984	This enzyme resembles cathepsin B (EC 3.4.22.1) in many physical-chemical properties including substrate specificity, requirement for thiol activators and inhibition both by thiol blocking reagents and by peptidyl diazomethyl ketones, but has a higher molecular size even after activation.	Sulfhydryl Compounds	134-139	cathepsin B	Homo sapiens	22-33
6504215-2	1984	This enzyme resembles cathepsin B (EC 3.4.22.1) in many physical-chemical properties including substrate specificity, requirement for thiol activators and inhibition both by thiol blocking reagents and by peptidyl diazomethyl ketones, but has a higher molecular size even after activation.	Sulfhydryl Compounds	174-179	cathepsin B	Homo sapiens	22-33
6671013-0	1983	High-performance liquid chromatography and fluorometric detection of biologically important thiols, derivatized with ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F).	Sulfhydryl Compounds	92-98	OXA1L mitochondrial inner membrane protein	Homo sapiens	142-147
6671013-1	1983	Thiol compounds which are derivatized with a fluorogenic reagent, ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F), are separated on a high-performance liquid chromatography column (muBondapak C18) and detected fluorometrically at 515 nm with excitation at 385 nm.	Sulfhydryl Compounds	0-5	OXA1L mitochondrial inner membrane protein	Homo sapiens	91-96
6671013-1	1983	Thiol compounds which are derivatized with a fluorogenic reagent, ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F), are separated on a high-performance liquid chromatography column (muBondapak C18) and detected fluorometrically at 515 nm with excitation at 385 nm.	Sulfhydryl Compounds	0-5	Bardet-Biedl syndrome 9	Homo sapiens	206-209
6584869-1	1983	The linear dichroism of iodoacetylrhodamine labels attached to the single reactive thiol groups of myosin heads was measured to determine the spatial orientation of myosin cross-bridges in single glycerinated skeletal muscle fibers.	Sulfhydryl Compounds	83-88	myosin heavy chain 14	Homo sapiens	99-105
6661182-14	1983	It is proposed that mercaptans increase the flexibility of the hinge region of the antibody molecule, allowing the formation of a higher-order complex with increased avidity for the CK-BB dimer.	Sulfhydryl Compounds	20-30	creatine kinase B	Homo sapiens	182-187
6661183-1	1983	Chicken liver fatty acid synthase is inhibited by the thiol-modifying reagents 5,5"-dithiobis-(2-nitrobenzoic acid) and iodoacetamide.	Sulfhydryl Compounds	54-59	fatty acid synthase	Gallus gallus	14-33
6358411-11	1983	We propose that copper may affect LHRH release as follows: copper, bound to an intracellular chelator (protein, peptide, or amino acid), oxidizes thiols of the LHRH granule, leading to a change in granule-membrane permeability and hence to LHRH release.	Sulfhydryl Compounds	146-152	gonadotropin releasing hormone 1	Rattus norvegicus	34-38
6358411-11	1983	We propose that copper may affect LHRH release as follows: copper, bound to an intracellular chelator (protein, peptide, or amino acid), oxidizes thiols of the LHRH granule, leading to a change in granule-membrane permeability and hence to LHRH release.	Sulfhydryl Compounds	146-152	gonadotropin releasing hormone 1	Rattus norvegicus	160-164
6358411-11	1983	We propose that copper may affect LHRH release as follows: copper, bound to an intracellular chelator (protein, peptide, or amino acid), oxidizes thiols of the LHRH granule, leading to a change in granule-membrane permeability and hence to LHRH release.	Sulfhydryl Compounds	146-152	gonadotropin releasing hormone 1	Rattus norvegicus	160-164
6665307-0	1983	An inhibitory effect of sulfhydryl compounds in the assay of rat and mouse thymic terminal deoxynucleotidyl transferase (TdT).	Sulfhydryl Compounds	24-44	deoxynucleotidyltransferase, terminal	Mus musculus	82-119
6665307-0	1983	An inhibitory effect of sulfhydryl compounds in the assay of rat and mouse thymic terminal deoxynucleotidyl transferase (TdT).	Sulfhydryl Compounds	24-44	deoxynucleotidyltransferase, terminal	Mus musculus	121-124
6665307-4	1983	Inhibition was significant at concentrations of sulfhydryl compounds commonly included in TdT assays (1 mM-2 mM).	Sulfhydryl Compounds	48-68	DNA nucleotidylexotransferase	Rattus norvegicus	90-93
6667024-2	1983	The purified enzyme is completely inactive (no activity detected between pH 6 and 9) but can be reactivated by thiol-reducing agents including dithiothreitol and thioredoxin.	Sulfhydryl Compounds	111-116	LOC101027257	Zea mays	162-173
6358411-0	1983	A possible role for copper-mediated oxidation of thiols in the regulation of the release of luteinizing hormone releasing hormone from isolated hypothalamic granules.	Sulfhydryl Compounds	49-55	gonadotropin releasing hormone 1	Rattus norvegicus	92-129
6358411-3	1983	and (b) is copper-stimulated LHRH release a result of an interaction of copper with thiol groups and, if so, does it require oxygen?	Sulfhydryl Compounds	84-89	gonadotropin releasing hormone 1	Rattus norvegicus	29-33
6607264-0	1983	The use of thiol-disulphide exchange chromatography for the automated isolation of alpha 1-antitrypsin and other plasma proteins with reactive thiol groups.	Sulfhydryl Compounds	11-16	serpin family A member 1	Homo sapiens	83-102
6139373-10	1983	A tryptic peptide containing the 3H label was isolated following digestion of [3H]C3b on activated thiol-Sepharose.	Sulfhydryl Compounds	99-104	complement C3	Homo sapiens	82-85
6607264-0	1983	The use of thiol-disulphide exchange chromatography for the automated isolation of alpha 1-antitrypsin and other plasma proteins with reactive thiol groups.	Sulfhydryl Compounds	143-148	serpin family A member 1	Homo sapiens	83-102
6622651-4	1983	The thiols, cysteine, glutathione, mercaptoacetic acid, and ascorbate have been shown to interact with those .OH adducts of dGMP and dG with oxidizing properties preferentially via an electron transfer process (k approximately 3 X 10(7)-1.4 X 10(9) dm3 mole-1 sec-1) as implied from the pH dependence of the rate constants.	Sulfhydryl Compounds	4-10	secretory blood group 1, pseudogene	Homo sapiens	260-265
6414464-1	1983	The kinetics of thiol-group alkylation in NADPH-cytochrome P-450 reductase during its inactivation by monobromobimane has been studied using the fluorimetric determination of S-bimane-L-cysteine by high-performance liquid chromatography.	Sulfhydryl Compounds	16-21	cytochrome p450 oxidoreductase	Homo sapiens	42-74
6414464-2	1983	Loss of activity during the reaction of NADPH-cytochrome P-450 reductase with monobromobimane is caused by the alkylation of one single critical cysteine residue, which can be protected against thiol-specific reagents by NADP(H).	Sulfhydryl Compounds	194-199	cytochrome p450 oxidoreductase	Homo sapiens	40-72
6661158-6	1983	It is possible that the T-2 effect is mediated through soluble thiol to cause cytoplasmic calcium decrease and loss of plasma membrane integrity.	Sulfhydryl Compounds	63-68	brachyury 2	Rattus norvegicus	24-27
6633508-10	1983	Apparent Km constants for some of these aromatic thiol compounds were in the nanomolar range, several orders of magnitude lower than those of the thiopurines and thiopyrimidines previously thought to be the only substrates for TPMT.	Sulfhydryl Compounds	49-54	thiopurine S-methyltransferase	Homo sapiens	227-231
6626524-0	1983	Forster energy transfer measurements of thiol 1 to thiol 2 distances in myosin subfragment 1.	Sulfhydryl Compounds	40-45	myosin heavy chain 14	Homo sapiens	72-78
6626524-0	1983	Forster energy transfer measurements of thiol 1 to thiol 2 distances in myosin subfragment 1.	Sulfhydryl Compounds	51-56	myosin heavy chain 14	Homo sapiens	72-78
6626524-1	1983	Forster energy transfer was used to measure the distance between reporter groups on the two reactive thiols of myosin, SH1 and SH2, and to detect changes in this distance upon binding of nucleotide.	Sulfhydryl Compounds	101-107	myosin heavy chain 14	Homo sapiens	111-117
6626153-5	1983	In addition, malonyl-CoA, when present simultaneously with Nbs2, protected CPT I activity against the desensitization effect of the thiol-group reagent.	Sulfhydryl Compounds	132-137	carnitine palmitoyltransferase 1B	Rattus norvegicus	75-80
6626153-6	1983	These results suggest that malonyl-CoA exerts an effect on one or more thiol groups of the enzyme, and that this effect is related to the ability of the metabolite to sensitize CPT I to malonyl-CoA inhibition.	Sulfhydryl Compounds	71-76	carnitine palmitoyltransferase 1B	Rattus norvegicus	177-182
6356291-13	1983	Streptolysin O is an oxygen-labile (thiol-activated) cytolysin.	Sulfhydryl Compounds	36-41	perforin 1	Homo sapiens	53-62
6193011-1	1983	The cysteine sulfhydryl groups of alpha 2-macroglobulin (alpha 2M) generated upon thrombin complex formation are in contact with the proteinase surface as evidenced by singlet--singlet energy transfer measurements from N-(iodoacetylaminoethyl)-5-naphthylamine-1-sulfonic acid-labeled thiol functions of alpha 2M to fluorescein isothiocyanate-labeled thrombin.	Sulfhydryl Compounds	284-289	alpha-2-macroglobulin	Homo sapiens	34-55
6193011-1	1983	The cysteine sulfhydryl groups of alpha 2-macroglobulin (alpha 2M) generated upon thrombin complex formation are in contact with the proteinase surface as evidenced by singlet--singlet energy transfer measurements from N-(iodoacetylaminoethyl)-5-naphthylamine-1-sulfonic acid-labeled thiol functions of alpha 2M to fluorescein isothiocyanate-labeled thrombin.	Sulfhydryl Compounds	284-289	alpha-2-macroglobulin	Homo sapiens	57-65
6193011-1	1983	The cysteine sulfhydryl groups of alpha 2-macroglobulin (alpha 2M) generated upon thrombin complex formation are in contact with the proteinase surface as evidenced by singlet--singlet energy transfer measurements from N-(iodoacetylaminoethyl)-5-naphthylamine-1-sulfonic acid-labeled thiol functions of alpha 2M to fluorescein isothiocyanate-labeled thrombin.	Sulfhydryl Compounds	284-289	coagulation factor II, thrombin	Homo sapiens	82-90
6882798-9	1983	It is concluded that: (1) H2O2, diamide and vitamin K-5 stimulate stereospecific sugar transport in soleus muscle by some mechanism other than lowering of ATP levels; (2) stimulation of sugar transport by oxidants is an ATP-dependent process; (3) some oxidant-sensitive sulphydryl group is critically involved in the process which activates muscle sugar transport.	Sulfhydryl Compounds	270-280	keratin 5	Rattus norvegicus	52-55
6639353-6	1983	This reduced thiol content was also reflected in a lowered activity of the thiolenzyme, glyceraldehyde-3-phosphate dehydrogenase in manganese exposed cells.	Sulfhydryl Compounds	13-18	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	88-128
6314192-1	1983	Chemical properties of receptor binding sites for thyrotropin-releasing hormone (TRH) in rat pituitary, retina, amygdala and hypothalamus were compared by examining the influence of sulfhydryl reagents on specific binding of [3H](3-Me-His2)-TRH ([3H]MeTRH).	Sulfhydryl Compounds	182-192	thyrotropin releasing hormone	Rattus norvegicus	81-84
6228071-0	1983	Transient activation of the Ca2+-ATPase from sarcoplasmic reticulum during thiol modification by 5,5"-dithiobis(2-nitrobenzoate).	Sulfhydryl Compounds	75-80	dynein axonemal heavy chain 8	Homo sapiens	33-39
6228071-1	1983	In the reaction of sarcoplasmic reticulum membranes with excess 5,5"-dithiobis(2-nitrobenzoate) (DTNB) some new features were observed: The Ca2+-dependent ATPase activities of increasingly modified preparations were considerably enhanced during the initial stage of thiol blockage.	Sulfhydryl Compounds	266-271	dynein axonemal heavy chain 8	Homo sapiens	155-161
6345618-1	1983	Crevicular fluid from gingivitis patients contains significant levels of a cysteine protease which was characterized as the lysosomal protease cathepsin B, as judged by substrate specificity, thiol dependence, pH optimum, kinetic parameters, pH stability, and inhibitor sensitivities.	Sulfhydryl Compounds	192-197	cathepsin B	Homo sapiens	143-154
6688532-1	1983	The active center thiol of monoalkylated pig heart lipoamide dehydrogenase, EHR, is induced to form an adduct to the enzyme-bound flavin adenine dinucleotide (FAD) at the C-4a position upon binding oxidized nicotinamide adenine dinucleotide (NAD+) [Thorpe, C., & Williams, C. H., Jr. (1976) J. Biol.	Sulfhydryl Compounds	18-23	dihydrolipoamide dehydrogenase	Sus scrofa	51-74
6311560-7	1983	First, tyrosinase oxidation of [3H]-estradiol was markedly inhibited by sulfhydryl reducing agents (monothioglycerol) that stabilize [3H]-estradiol binding to estrogen receptor.	Sulfhydryl Compounds	72-82	tyrosinase	Homo sapiens	7-17
6311560-7	1983	First, tyrosinase oxidation of [3H]-estradiol was markedly inhibited by sulfhydryl reducing agents (monothioglycerol) that stabilize [3H]-estradiol binding to estrogen receptor.	Sulfhydryl Compounds	72-82	estrogen receptor 1	Homo sapiens	159-176
6352535-7	1983	All three disulfide bonds of these insulin derivatives undergo reduction with tributylphosphine to give six sulfhydryls.	Sulfhydryl Compounds	108-119	insulin	Homo sapiens	35-42
6853546-0	1983	Fluorescence energy transfer studies on the proximity of the two essential thiols of myosin subfragment-1.	Sulfhydryl Compounds	75-81	myosin heavy chain 14	Homo sapiens	85-91
6305978-7	1983	A second enzyme, designated E2, is bound to the ubiquitin column when E1 and ATP are present, and is eluted with a thiol compound at high concentration.	Sulfhydryl Compounds	115-120	small nucleolar RNA, H/ACA box 73A	Homo sapiens	70-80
6615425-9	1983	Conventional two-substrate steady-state analysis of the thiol:protein-disulphide oxidoreductase activity indicates that it follows a ternary-complex mechanism.	Sulfhydryl Compounds	56-61	thioredoxin reductase 1	Homo sapiens	81-95
6555044-0	1983	The reaction of iodine and thiol-blocking reagents with human complement components C2 and factor B.	Sulfhydryl Compounds	27-32	complement C2	Homo sapiens	84-99
6555044-2	1983	Human complement components C2 and Factor B each contain one free thiol group/molecule.	Sulfhydryl Compounds	66-71	complement C2	Homo sapiens	28-43
6619113-2	1983	Porcine liver aminopeptidase was inactivated by various sulfhydryl-reactive reagents, whose inactivation rates were in the order: p-chloromercuribenzoate(PCMB) greater than HgCl2 greater than 2,2"-dithiodipyridine greater than 5,5"-dithiobis(2-nitrobenzoic acid)(DTNB).	Sulfhydryl Compounds	56-66	carboxypeptidase Q	Homo sapiens	14-28
6882359-10	1983	This material, added to yellow butyryl-CoA dehydrogenase with an excess of thiol, re-forms green enzyme, but it loses this ability on storage.	Sulfhydryl Compounds	75-80	acyl-CoA dehydrogenase short chain	Homo sapiens	31-56
6344921-0	1983	Insulin receptor: insulin-modulated interconversion between distinct molecular forms involving disulfide-sulfhydryl exchange.	Sulfhydryl Compounds	105-115	insulin receptor	Homo sapiens	0-16
6344921-0	1983	Insulin receptor: insulin-modulated interconversion between distinct molecular forms involving disulfide-sulfhydryl exchange.	Sulfhydryl Compounds	105-115	insulin	Homo sapiens	18-25
6838225-1	1983	Rat liver glucokinase (EC 2.7.1.2) undergoes two distinct sulfhydryl-related reversible kinetic transitions.	Sulfhydryl Compounds	58-68	glucokinase	Rattus norvegicus	10-21
6847195-1	1983	Peptidyl diazomethyl ketones inactivate cathepsin B apparently by alkylation of the active center thiol following complex formation as in the case of benzyloxycarbonyl (Cbz)-Phe-AlaCHN2.	Sulfhydryl Compounds	98-103	cathepsin B	Homo sapiens	40-51
6840089-0	1983	Identification of the thiol groups in human ceruloplasmin.	Sulfhydryl Compounds	22-27	ceruloplasmin	Homo sapiens	44-57
6840089-1	1983	Human ceruloplasmin was attached to activated thiol-Sepharose via its thiol groups and was then digested with pepsin.	Sulfhydryl Compounds	46-51	ceruloplasmin	Homo sapiens	6-19
6840089-1	1983	Human ceruloplasmin was attached to activated thiol-Sepharose via its thiol groups and was then digested with pepsin.	Sulfhydryl Compounds	70-75	ceruloplasmin	Homo sapiens	6-19
6838225-13	1983	These sulfhydryl-related transitions may be important in regulation of glucokinase activity, since glucokinase is very sensitive (at least 20-fold differential activity) to concentrations of glutathione within the physiological range, perhaps allowing the normally variable glutathione levels or cytosolic redox potential to modify the rate of uptake and storage of blood glucose through control of glucokinase activity.	Sulfhydryl Compounds	6-16	glucokinase	Rattus norvegicus	71-82
6189495-10	1983	Sulfhydryl compounds seemed to play important roles in the detoxification of Trp-P-2.	Sulfhydryl Compounds	0-20	polycystin 2, transient receptor potential cation channel	Rattus norvegicus	77-84
6838225-13	1983	These sulfhydryl-related transitions may be important in regulation of glucokinase activity, since glucokinase is very sensitive (at least 20-fold differential activity) to concentrations of glutathione within the physiological range, perhaps allowing the normally variable glutathione levels or cytosolic redox potential to modify the rate of uptake and storage of blood glucose through control of glucokinase activity.	Sulfhydryl Compounds	6-16	glucokinase	Rattus norvegicus	99-110
6838225-13	1983	These sulfhydryl-related transitions may be important in regulation of glucokinase activity, since glucokinase is very sensitive (at least 20-fold differential activity) to concentrations of glutathione within the physiological range, perhaps allowing the normally variable glutathione levels or cytosolic redox potential to modify the rate of uptake and storage of blood glucose through control of glucokinase activity.	Sulfhydryl Compounds	6-16	glucokinase	Rattus norvegicus	99-110
6853369-1	1983	Versatile methods for displacement of the C-3 sulfur side chain of carbapenems with other thiol groups.	Sulfhydryl Compounds	90-95	complement C3	Homo sapiens	42-45
6832146-0	1983	Interaction of ADP and magnesium with the active site of myosin subfragment-1 observed by reactivity changes of the critical thiols and by direct binding methods at low and high ionic strength.	Sulfhydryl Compounds	125-131	myosin heavy chain 14	Homo sapiens	57-63
6188466-0	1983	Localization of the proteinase-induced thiol groups in alpha 2-macroglobulin.	Sulfhydryl Compounds	39-44	alpha-2-macroglobulin	Homo sapiens	55-76
6188466-1	1983	Free thiol groups released on proteolytic attack of alpha 2-macroglobulin by trypsin or chymotrypsin bind covalently to thiopropyl-Sepharose, indicating that they are located at the surface of the complexes.	Sulfhydryl Compounds	5-10	alpha-2-macroglobulin	Homo sapiens	52-73
6839884-1	1983	3-(4-Maleimidylphenyl)-4-methyl-7-diethylamino coumarin (CPM), is a fluorescent thiol-binding agent.	Sulfhydryl Compounds	80-85	carboxypeptidase M	Cricetulus griseus	57-60
6340679-0	1983	Identification of thiol:protein disulfide oxidoreductase activity in cultured human fibroblasts: dependence of enzyme activity on growth conditions.	Sulfhydryl Compounds	18-23	thioredoxin reductase 1	Homo sapiens	42-56
6340679-1	1983	Thiol:protein disulfide oxidoreductase activity was assayed in extracts of cultured normal human skin fibroblasts.	Sulfhydryl Compounds	0-5	thioredoxin reductase 1	Homo sapiens	24-38
6340679-5	1983	Antibodies raised against purified bovine liver thiol:protein disulfide oxidoreductase immunoprecipitated all of the activity present in fibroblast extracts.	Sulfhydryl Compounds	48-53	thioredoxin reductase 1	Homo sapiens	72-86
6340679-6	1983	The thiol:protein disulfide oxidoreductase from human fibroblasts thus appears to share antigenic determinants with the bovine liver enzyme.	Sulfhydryl Compounds	4-9	thioredoxin reductase 1	Homo sapiens	28-42
6824640-0	1983	Trapping of transition metal-nucleotide complexes in myosin subfragment 1 by cross-linking thiols; divalent transition metal probes of the active site.	Sulfhydryl Compounds	91-97	myosin heavy chain 14	Homo sapiens	53-59
6301526-0	1983	Affinity chromatography of brain cyclic nucleotide phosphodiesterase using 3-(2-pyridyldithio)propionyl-substituted calmodulin linked to thiol-sepharose.	Sulfhydryl Compounds	137-142	calmodulin 1	Homo sapiens	116-126
6301526-1	1983	[3-(2-Pyridylthio)propionyl]calmodulin (PDP-CaM), an activated thiol derivative of calmodulin (CaM), was synthesized.	Sulfhydryl Compounds	63-68	calmodulin 1	Homo sapiens	28-38
6301526-1	1983	[3-(2-Pyridylthio)propionyl]calmodulin (PDP-CaM), an activated thiol derivative of calmodulin (CaM), was synthesized.	Sulfhydryl Compounds	63-68	calmodulin 1	Homo sapiens	44-47
6301526-1	1983	[3-(2-Pyridylthio)propionyl]calmodulin (PDP-CaM), an activated thiol derivative of calmodulin (CaM), was synthesized.	Sulfhydryl Compounds	63-68	calmodulin 1	Homo sapiens	95-98
6301526-3	1983	PDP-CaM was covalently coupled to free thiol-Sepharose 4B through formation of a stable mixed disulfide bond for use in affinity chromatography.	Sulfhydryl Compounds	39-44	calmodulin 1	Homo sapiens	4-7
6846823-0	1983	A novel fluorogenic reagent for thiols: ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate.	Sulfhydryl Compounds	32-38	OXA1L mitochondrial inner membrane protein	Homo sapiens	65-70
6846823-1	1983	Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate (SBD-F) was newly synthesized as a fluorogenic reagent for thiol compounds.	Sulfhydryl Compounds	112-117	OXA1L mitochondrial inner membrane protein	Homo sapiens	25-30
6140804-0	1983	A new sensitive, thiol tolerant method for the determination of inorganic pyrophosphatase.	Sulfhydryl Compounds	17-22	inorganic pyrophosphatase 1	Homo sapiens	64-89
6140804-1	1983	In this work a new sensitive, thiol tolerant method for the determination of inorganic pyrophosphatase (EC 3.6.1.1) was developed.	Sulfhydryl Compounds	30-35	inorganic pyrophosphatase 1	Homo sapiens	77-102
6338918-0	1983	Generation of an acid-stable and protein-bound persulfide-like residue in alkali- or sulfhydryl-treated insulin by a mechanism consonant with the beta-elimination hypothesis of disulfide bond lysis.	Sulfhydryl Compounds	85-95	insulin	Homo sapiens	104-111
6824640-5	1983	U.S.A. 76, 4966] have shown it is possible to trap MgADP and other nucleotides stably at the active site of myosin by cross-linking two thiol groups.	Sulfhydryl Compounds	136-141	myosin heavy chain 14	Homo sapiens	108-114
6202223-2	1983	The free thiol groups generated upon reaction of alpha 2-macroglobulin with trypsin or chymotrypsin react with thiopropyl Sepharose, indicating that they are located at the surface of the complexes.	Sulfhydryl Compounds	9-14	alpha-2-macroglobulin	Homo sapiens	49-70
6202223-3	1983	Singlet-singlet energy transfer experiments from labeled proteinases to labeled thiols of alpha 2-macroglobulin show that the thiol groups are in close contact with the proteinase molecules whether the latter are covalently or noncovalently bound to alpha 2-macroglobulin.	Sulfhydryl Compounds	80-86	alpha-2-macroglobulin	Homo sapiens	90-111
6202223-3	1983	Singlet-singlet energy transfer experiments from labeled proteinases to labeled thiols of alpha 2-macroglobulin show that the thiol groups are in close contact with the proteinase molecules whether the latter are covalently or noncovalently bound to alpha 2-macroglobulin.	Sulfhydryl Compounds	80-85	alpha-2-macroglobulin	Homo sapiens	90-111
6202223-5	1983	Using the same approach we demonstrate that the active sites of chymotrypsin molecules are separated by a distance of at least 20 A from the thiols group of each alpha 2-macroglobulin subunit.	Sulfhydryl Compounds	141-147	alpha-2-macroglobulin	Homo sapiens	162-183
7150622-1	1982	The activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hydroxymethylglutaryl-CoA reductase, EC 1.1.1.34) in preparations of thiol-deficient rat liver microsomes and microsomes containing thiols have been compared.	Sulfhydryl Compounds	197-203	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	16-63
6602098-2	1983	When albumin is present as a source of thiol groups, Fab fragments previously treated with N-ethylmaleimide (NEM) will dissociate from the agglutinators (fluid phase).	Sulfhydryl Compounds	39-44	FA complementation group B	Homo sapiens	53-56
6602098-4	1983	Prior to erythrocyte sensitization, the agglutinator site on Fab fragments can be blocked by thiol-disulfide exchange.	Sulfhydryl Compounds	93-98	FA complementation group B	Homo sapiens	61-64
6759610-1	1982	Previous studies from this (Zirkin et al., "80) and other (Marushige and Marushige, "78) laboratories have shown that proteinase associated with mammalian sperm nuclei is involved in thiol-induced sperm nuclear decondensation and protamine degradation in vitro.	Sulfhydryl Compounds	183-188	endogenous retrovirus group K member 25	Homo sapiens	118-128
6192095-5	1983	Inhibition of both ATPase and histamine release requires a sulfhydryl-reactive olefinic bond, but sulfhydryl reactivity alone is not sufficient, as certain analogs which have a high capacity to react with sulfhydryl moieties were not active.	Sulfhydryl Compounds	59-69	dynein axonemal heavy chain 8	Homo sapiens	19-25
7150622-0	1982	Thiol-disulfide-dependent interconversion of active and latent forms of rat hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase.	Sulfhydryl Compounds	0-5	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	84-131
7150622-1	1982	The activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hydroxymethylglutaryl-CoA reductase, EC 1.1.1.34) in preparations of thiol-deficient rat liver microsomes and microsomes containing thiols have been compared.	Sulfhydryl Compounds	134-139	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	16-63
7119774-2	1982	The oxidation of cysteine by ceruloplasmin has several properties in common with the Cu(II) catalyzed oxidation of cysteine: pH maxima, thiol specificity, lack of inhibition by anions, and high sensitivity to inhibition by copper complexing reagents.	Sulfhydryl Compounds	136-141	ceruloplasmin	Homo sapiens	29-42
6961918-5	1982	The complete protection afforded by NAD+ against the action of disulphiram suggests that the essential thiol group may be involved in binding of NAD+ to the xanthine oxidoreductase molecule.	Sulfhydryl Compounds	103-108	xanthine dehydrogenase	Rattus norvegicus	157-180
7184904-1	1982	Cardiac ODC was prepared from rats after the injection of isoproterenol and was partially purified by thiol-affinity chromatography.	Sulfhydryl Compounds	102-107	ornithine decarboxylase 1	Rattus norvegicus	8-11
6957247-6	1982	The two sulfotransferases differed in the requirement for sulfhydryl compounds; in the absence of sulfhydryl compounds, the activity of chondroitin 4-sulfotransferase was very low, whereas the activity of chondroitin 6-sulfotransferase was essentially unaffected.	Sulfhydryl Compounds	58-78	carbohydrate sulfotransferase 3	Gallus gallus	205-235
7150538-1	1982	The conformation of troponin C (TN-C) isolated from the white muscle of pike (Esox lucius), in the Ca2+ and metal-free states, was studied by circular dichroism, absorption difference spectroscopy, solvent perturbation difference spectroscopy, intrinsic fluorescence, thiol titration, and 1H nuclear magnetic resonance spectroscopy.	Sulfhydryl Compounds	268-273	tenascin	Esox lucius	20-30
6961918-0	1982	Involvement of a single thiol group in the conversion of the NAD+-dependent activity of rat liver xanthine oxidoreductase to the O2-dependent activity.	Sulfhydryl Compounds	24-29	xanthine dehydrogenase	Rattus norvegicus	98-121
6214556-1	1982	Modulation of phosphofructokinase activity by thiol/disulfide exchange.	Sulfhydryl Compounds	46-51	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	14-33
6214556-8	1982	These equilibrium constants for thiol/disulfide exchange are such that modulation of phosphofructokinase activity by thiol/disulfide exchange in vivo is feasible.	Sulfhydryl Compounds	32-37	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	85-104
6214556-8	1982	These equilibrium constants for thiol/disulfide exchange are such that modulation of phosphofructokinase activity by thiol/disulfide exchange in vivo is feasible.	Sulfhydryl Compounds	117-122	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	85-104
6807529-5	1982	The activities of CSAp in both plasma and tumor were similarly destroyed by treatment with a thiol reagent.	Sulfhydryl Compounds	93-98	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	18-22
7096338-4	1982	Proalbumin of smooth microsomes was found to contain a single thiol, which is proposed to be the noncoupling cysteine occurring residue 34 in circulating albumin.	Sulfhydryl Compounds	62-67	albumin	Rattus norvegicus	3-10
6807576-3	1982	The antibody-bound form of labeled prolactin was separated from the unbound form by a method based on the thiol-disulfide interchange reaction.	Sulfhydryl Compounds	106-111	prolactin	Homo sapiens	35-44
6282878-2	1982	The binding of thiol, thiolate, thioether, and disulfide sulfur donor ligands to ferric cytochrome P-450-CAM and myoglobin has been investigated by UV-visible absorption, magnetic circular dichroism (MCD), and EPR spectroscopy.	Sulfhydryl Compounds	15-20	myoglobin	Homo sapiens	88-122
6282878-5	1982	In contrast, only the thiolate-bound form is seen for myoglobin regardless of thiol acidity or solution pH (5.5-11.0), indicating that the heme iron of myoglobin is less electron-rich than that of P-450.	Sulfhydryl Compounds	22-27	myoglobin	Homo sapiens	54-63
6282878-5	1982	In contrast, only the thiolate-bound form is seen for myoglobin regardless of thiol acidity or solution pH (5.5-11.0), indicating that the heme iron of myoglobin is less electron-rich than that of P-450.	Sulfhydryl Compounds	22-27	myoglobin	Homo sapiens	152-161
7104741-3	1982	Thiol-reducing agents, such as dithiothreitol and cysteine, increased the biological activity of GMF.	Sulfhydryl Compounds	0-5	glia maturation factor beta	Homo sapiens	97-100
7104741-4	1982	These data suggest the presence of a surface receptor to GMF on the glioblasts, while the reduction of the thiol group(s) in GMF promotes the binding to its receptor.	Sulfhydryl Compounds	107-112	glia maturation factor beta	Homo sapiens	125-128
7115885-1	1982	Reaction kinetic studies of the sulfhydryl-directed fluorescent probes N-(1-pyrene)maleimide (PM) and N-(1-pyrenyl)iodoacetamide with actin from rabbit skeletal muscle showed that there were three accessible sulfhydryl groups in actin.	Sulfhydryl Compounds	32-42	actin	Oryctolagus cuniculus	134-139
7115885-1	1982	Reaction kinetic studies of the sulfhydryl-directed fluorescent probes N-(1-pyrene)maleimide (PM) and N-(1-pyrenyl)iodoacetamide with actin from rabbit skeletal muscle showed that there were three accessible sulfhydryl groups in actin.	Sulfhydryl Compounds	32-42	actin	Oryctolagus cuniculus	229-234
6291012-5	1982	Thiol reagents reduced the binding activity of the receptor, suggesting that an intrachain disulfide bond may form an important constituent of the binding site for TRH.	Sulfhydryl Compounds	0-5	thyrotropin releasing hormone	Rattus norvegicus	164-167
7047162-4	1982	It is a thiol, cathepsin-B-like proteinase with an apparent molecular weight of 68 000 and is composed of a single polypeptide chain.	Sulfhydryl Compounds	8-13	endogenous retrovirus group K member 25	Homo sapiens	32-42
6181786-0	1982	Nascent alpha 2-macroglobulin-trypsin complex: incorporation of amines and water at the thiol esterified Glx-residues of alpha 2-macroglobulin during activation with trypsin.	Sulfhydryl Compounds	88-93	alpha-2-macroglobulin	Homo sapiens	8-29
6181786-0	1982	Nascent alpha 2-macroglobulin-trypsin complex: incorporation of amines and water at the thiol esterified Glx-residues of alpha 2-macroglobulin during activation with trypsin.	Sulfhydryl Compounds	88-93	alpha-2-macroglobulin	Homo sapiens	121-142
7044763-1	1982	We have obtained evidence of thiol endopeptidases in the thyroid which are active in thyroglobulin degradation in vitro.	Sulfhydryl Compounds	29-34	LOW QUALITY PROTEIN: thyroglobulin	Oryctolagus cuniculus	85-98
7044763-8	1982	The action of the thiol endopeptidases on [125I]thyroglobulin was analyzed by polyacrylamide gel electrophoresis in sodium dodecyl sulfate or in sodium dodecyl sulfate and urea.	Sulfhydryl Compounds	18-23	LOW QUALITY PROTEIN: thyroglobulin	Oryctolagus cuniculus	48-61
7044763-12	1982	Each of the thiol endopeptidases had a synergistic effect when incubated with cathepsin D and [125I]thyroglobulin.	Sulfhydryl Compounds	12-17	cathepsin D	Oryctolagus cuniculus	78-89
7044763-12	1982	Each of the thiol endopeptidases had a synergistic effect when incubated with cathepsin D and [125I]thyroglobulin.	Sulfhydryl Compounds	12-17	LOW QUALITY PROTEIN: thyroglobulin	Oryctolagus cuniculus	100-113
6122685-7	1982	Dipeptidase, in contrast to aminopeptidase M, is inhibited by thiol compounds; Cys-Gly, in particular, is a potent inhibitor (Ki = 20 microM).	Sulfhydryl Compounds	62-67	alanyl aminopeptidase, membrane	Rattus norvegicus	28-44
6810885-0	1982	Copper inhibition of glutathione reductase and its reversal with gold thiolates, thiol, and disulfide compounds.	Sulfhydryl Compounds	70-75	glutathione-disulfide reductase	Homo sapiens	21-42
7052070-5	1982	Sephadex G-75 chromatography of the acid-soluble products of insulin digestion by cathepsin D or L suggested that thiols can reduce disulphide bonds in proteins after limited proteolysis.	Sulfhydryl Compounds	114-120	insulin	Homo sapiens	61-68
7052070-5	1982	Sephadex G-75 chromatography of the acid-soluble products of insulin digestion by cathepsin D or L suggested that thiols can reduce disulphide bonds in proteins after limited proteolysis.	Sulfhydryl Compounds	114-120	cathepsin D	Homo sapiens	82-93
7069515-6	1982	The mRNA was translated in a wheat germ system and newly synthesized metallothionein was isolated by activated thiol--Sepharose 4B chromatography.	Sulfhydryl Compounds	111-116	metallothionein-like protein 1	Triticum aestivum	69-84
7101470-5	1982	The data obtained about the influence of the various proteolytic enzyme inhibitors and activators on the thiol-activated cathepsin activity show a definite similarity of the enzyme with the thiol proteinases of the rat liver lysosomes, cathepsin B1 and L.	Sulfhydryl Compounds	105-110	cathepsin B	Rattus norvegicus	236-248
7060519-0	1982	Thiol regulation of protein, growth hormone, and prolactin release from isolated adenohypophysial secretory granules.	Sulfhydryl Compounds	0-5	prolactin	Homo sapiens	49-58
7060523-5	1982	We conclude that thiol cathepsins from cockerel liver cause proteolytic degradation of the estrogen receptor.	Sulfhydryl Compounds	17-22	estrogen receptor 1	Homo sapiens	91-108
7096319-0	1982	The distribution of thiol groups among the tryptic fragments of the heavy chain of myosin subfragment-1.	Sulfhydryl Compounds	20-25	myosin heavy chain 14	Homo sapiens	83-89
6282319-6	1982	Reduction of modified G3PD with 5 mM dithioerythritol under nondenaturing conditions released the inhibitor blocking the active-site thiol and completely restored enzyme activity while leaving the cross-link intact.	Sulfhydryl Compounds	133-138	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	22-26
6277905-7	1982	Selective derivatization of the thiol site with iodoacetamide results in a modified enzyme capable of catalyzing only ATP:PPi exchange and in forming only ubiquitin adenylate.	Sulfhydryl Compounds	32-37	ubiquitin	Oryctolagus cuniculus	155-164
6277905-8	1982	Derivatization of the thiol site prevents conjugate formation in a reconstituted system, demonstrating that the ubiquitin thiolester is the proximal donor for subsequent conjugate formation.	Sulfhydryl Compounds	22-27	ubiquitin	Oryctolagus cuniculus	112-121
7037172-1	1982	Spontaneous mammary tumors from C3H/HeJ mice and transplants established from mammary tumors were investigated for their capacity to secrete thiol-dependent proteinase activity in organ culture explants.	Sulfhydryl Compounds	141-146	endogenous retrovirus group K member 18	Homo sapiens	157-167
6120852-3	1982	Thus, somatostatin exhibits organoprotection dependent on endogenous sulfhydryls.	Sulfhydryl Compounds	69-80	somatostatin	Rattus norvegicus	6-18
6177002-8	1982	Sulfhydryl-specific binding of native IFN-gamma to an Affi-Gel 501 column suggested that this IFN contains free sulfhydryl.	Sulfhydryl Compounds	112-122	interferon gamma	Homo sapiens	38-47
7185255-1	1982	Sulfhydryl substances (cysteine, glutathione, cysteamine and BAL) provide protection against experimental gastric ulcer induced by indomethacin while being ulcerogenous in stress-ulcer.	Sulfhydryl Compounds	0-21	poly(ADP-ribose) polymerase family member 9	Homo sapiens	61-64
6175959-3	1982	Fragment C3d remained attached to the thiol-Sepharose and was subsequently eluted with L-cysteine.	Sulfhydryl Compounds	38-43	endogenous retrovirus group K member 13	Homo sapiens	9-12
6175959-6	1982	Specific chemical cleavage of the alpha-chain was achieved after S-cyanylation of the thiol.	Sulfhydryl Compounds	86-91	Fc gamma receptor and transporter	Homo sapiens	34-45
7053372-2	1982	Rabbit Fab" antibody fragments were covalently couple to preformed large unilamellar vesicles using a new sulfhydryl-reactive phospholipid derivative N-[4-(p-maleimidophenyl)butyryl]phosphatidylethanolamine (MPB-PE).	Sulfhydryl Compounds	106-116	FA complementation group B	Homo sapiens	7-10
7053373-6	1982	Progesterone receptor activation by sulfhydryl reduction was a reversible process, dependent on addition or removal (by dialysis) of the reducing agent.	Sulfhydryl Compounds	36-46	progesterone receptor	Homo sapiens	0-21
6276374-3	1982	Thus, to address this problem, disulfide bonds of ribonuclease-A and lysozyme were reductively cleaved under denaturing conditions, and the resulting 7-8 sulfhydryl groups were treated with a new sulfhydryl group reagent containing selenium, 6,6"-diselenobis(3-nitrobenzoic acid), to give proteins containing covalently attached selenium in the form of selenenyl sulfides.	Sulfhydryl Compounds	154-164	lysozyme	Homo sapiens	69-77
6276374-3	1982	Thus, to address this problem, disulfide bonds of ribonuclease-A and lysozyme were reductively cleaved under denaturing conditions, and the resulting 7-8 sulfhydryl groups were treated with a new sulfhydryl group reagent containing selenium, 6,6"-diselenobis(3-nitrobenzoic acid), to give proteins containing covalently attached selenium in the form of selenenyl sulfides.	Sulfhydryl Compounds	196-206	lysozyme	Homo sapiens	69-77
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Sulfhydryl Compounds	204-214	renin	Canis lupus familiaris	24-29
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Sulfhydryl Compounds	204-214	renin	Canis lupus familiaris	97-102
7032805-2	1982	A high-molecular-weight renin (M(r) 60 000) was formed by the reaction of a low-molecular-weight renin (M(r) 40 000) with a renin-binding substance in canine renal cortical extract in the presence of the sulphydryl (SH) group oxidizing agent potassium tetrathionate; thus the reaction required SH oxidation.	Sulfhydryl Compounds	204-214	renin	Canis lupus familiaris	97-102
6275890-1	1982	Use of thiol-sepharose-bound Saccharomyces cerevisiae cytochrome c. A method for simultaneous purification of cytochrome c reductase and cytochrome c oxidase using a cytochrome c affinity column is presented.	Sulfhydryl Compounds	7-12	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	137-157
7158169-0	1982	Human muscle glyceraldehyde-3-phosphate dehydrogenase: reactivity of sulphydryl groups.	Sulfhydryl Compounds	69-79	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	13-53
7158169-2	1982	The kinetics of the reaction of thiol groups of glyceraldehyde-3-phosphate dehydrogenase from human muscle with 5,5"-dithiobis-2-nitrobenzoate (DTNB) was studied spectrophotometrically using the conventional and stopped-flow methods.	Sulfhydryl Compounds	32-37	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	48-88
7028769-4	1981	It also demonstrated that the renin--RBP complex was formed at 37 degrees C in the absence of sulfhydryl reagent.	Sulfhydryl Compounds	94-104	renin	Homo sapiens	30-35
6896145-0	1981	Amino acid sequence of the tryptic peptide containing the catalytic-site thiol group of bovine liver uridine diphosphate glucose dehydrogenase.	Sulfhydryl Compounds	73-78	glucose dehydrogenase	Bos taurus	121-142
6896145-1	1981	The catalytic-site thiol groups of UDP-glucose dehydrogenase from bovine liver were carboxymethylated with iodo[2-14C]acetate or with iodoacetamidofluorescein.	Sulfhydryl Compounds	19-24	UDP-glucose 6-dehydrogenase	Bos taurus	35-60
7298626-4	1981	Of the various chemicals tested, only those which contained either a free amino group (except lysine) and/or a free sulfhydryl group (e.g. semicarbazide, cysteine, glycine, glucosamine) effectively blocked (40-80%) the binding of 14C as well as protected against acrolein-induced denaturation of cytochrome P-450.	Sulfhydryl Compounds	116-126	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	296-312
7320103-0	1981	Covalent chromatography as a means of isolating thiol peptides from large proteins: application to human ceruloplasmin.	Sulfhydryl Compounds	48-53	ceruloplasmin	Homo sapiens	105-118
7121292-0	1982	Chemical modification of myosin by active-site trapping of metal-nucleotides with thiol crosslinking reagents.	Sulfhydryl Compounds	82-87	myosin heavy chain 14	Homo sapiens	25-31
6797474-1	1981	The total -SH content of purified NADPH-cytochrome P-450 reductase (NADPH: ferricytochrome oxidoreductase, EC 1.6.2.4) from rabbit liver microsomes accessible to an excess equivalent of PCMB was 7.0 +/- 0.3 mol thiol groups/mol protein.	Sulfhydryl Compounds	211-216	NADPH--cytochrome P450 reductase	Oryctolagus cuniculus	34-66
7032599-1	1981	Pepsin treatment of ascitic fluid from patients with neoplasia generated a cysteine (thiol) proteinase activity which resembles cathepsin B (EC 3.4.22.1) in its requirements for thiol activators, susceptibility to inhibitors and specificity for synthetic substrates.	Sulfhydryl Compounds	85-90	endogenous retrovirus group K member 25	Homo sapiens	92-102
7032599-1	1981	Pepsin treatment of ascitic fluid from patients with neoplasia generated a cysteine (thiol) proteinase activity which resembles cathepsin B (EC 3.4.22.1) in its requirements for thiol activators, susceptibility to inhibitors and specificity for synthetic substrates.	Sulfhydryl Compounds	85-90	cathepsin B	Homo sapiens	128-139
7032600-5	1981	104, 249-254) and of ascertaining the full physiological significance of ion binding, we investigated the effects of ions and thiol reagents on the proteolysis of yeast phosphoglycerate kinase (ATP: 3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3).	Sulfhydryl Compounds	126-131	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	169-192
7032600-5	1981	104, 249-254) and of ascertaining the full physiological significance of ion binding, we investigated the effects of ions and thiol reagents on the proteolysis of yeast phosphoglycerate kinase (ATP: 3-phospho-D-glycerate 1-phosphotransferase, EC 2.7.2.3).	Sulfhydryl Compounds	126-131	F1F0 ATP synthase subunit gamma	Saccharomyces cerevisiae S288C	194-200
6950391-1	1981	Thioredoxin and glutaredoxin may be important in regulating cell metabolism by mediating interchanges between sulfhydryl and disulfide groups.	Sulfhydryl Compounds	110-120	thioredoxin	Homo sapiens	0-11
6950391-1	1981	Thioredoxin and glutaredoxin may be important in regulating cell metabolism by mediating interchanges between sulfhydryl and disulfide groups.	Sulfhydryl Compounds	110-120	glutaredoxin	Homo sapiens	16-28
6978710-3	1981	One of the activation products of C4, C4b, was prepared, and the reactive thiol group on the alpha"-chain was radioactively labelled with iodo[2-14C]acetic acid.	Sulfhydryl Compounds	74-79	Fc gamma receptor and transporter	Homo sapiens	93-105
6457648-6	1981	A reduction in the number of thiol groups present on the ATPase molecule parallels the reduction of enzyme activity and changes in the protein mobility.	Sulfhydryl Compounds	29-34	dynein axonemal heavy chain 8	Homo sapiens	57-63
7028769-4	1981	It also demonstrated that the renin--RBP complex was formed at 37 degrees C in the absence of sulfhydryl reagent.	Sulfhydryl Compounds	94-104	renin binding protein	Homo sapiens	37-40
6457035-1	1981	The fluorescent thiol reagent N-(1-anilinonaphthyl-4)maleimide (ANM) reacts covalently with the Ca2+ ATPase moiety of fragmented sarcoplasmic reticulum in two phases as determined by the increase of fluorescence intensity and optical density at 350 nm.	Sulfhydryl Compounds	16-21	carbonic anhydrase 2	Homo sapiens	96-107
6453617-13	1981	Thiol groups of the 17 000-light chain (and some heavy chains) are probably located peripheral to the active site region of gizzard myosin and they are involved in maintaining the enzymic activity of this protein.	Sulfhydryl Compounds	0-5	myosin, heavy chain 15	Gallus gallus	132-138
7240248-2	1981	Upon reaction with N-ethylmaleimide, a single sulfhydryl residue/Mr = 50,000 subunit of phenylalanine hydroxylase is modified.	Sulfhydryl Compounds	46-56	phenylalanine hydroxylase	Rattus norvegicus	88-113
6265763-3	1981	The main contribution to the ESR absorption for both types of thiol groups gives the spin labelled Ca-ATPase.	Sulfhydryl Compounds	62-67	spindlin 1	Homo sapiens	85-89
6912277-9	1981	Unlike native C3, C3 bearing a single reactive sulfhydryl group was capable of generating fluid-phase C3 convertase with Factors B, D, and P and was cleaved by Factor I (C3b inactivator) in the presence of Factor H (beta 1H).	Sulfhydryl Compounds	47-57	complement factor H	Homo sapiens	206-214
6912277-9	1981	Unlike native C3, C3 bearing a single reactive sulfhydryl group was capable of generating fluid-phase C3 convertase with Factors B, D, and P and was cleaved by Factor I (C3b inactivator) in the presence of Factor H (beta 1H).	Sulfhydryl Compounds	47-57	complement factor H	Homo sapiens	216-223
6790577-5	1981	Purified H-protein from the patient did not react with lipoamide dehydrogenase, and titration of thiol groups with [2,3-14C]N-ethylmaleimide suggested that this H-protein is devoid of lipoic acid.	Sulfhydryl Compounds	97-102	myosin binding protein H	Homo sapiens	161-170
6172116-8	1981	After the reaction with a proteinase or with methylamine, a free thiol group was detectable on each subunit of alpha 2M.	Sulfhydryl Compounds	65-70	alpha-2-macroglobulin	Homo sapiens	111-119
16435483-6	1981	The ACAT was inhibited by taurocholate and by the thiol-blocking agent 5,5"-dithiobis(2-nitrobenzoic acid).	Sulfhydryl Compounds	50-55	sterol O-acyltransferase 1	Homo sapiens	4-8
7237230-0	1981	L-phenylalanine induced changes of sulfhydryl reactivity in rabbit muscle pyruvate kinase.	Sulfhydryl Compounds	35-45	pyruvate kinase PKLR	Oryctolagus cuniculus	74-89
7213779-7	1981	These results provide evidence that apolipoprotein B proteolysis progresses in distinct stages via specific breakdown products and suggest that the thiol cathepsins become more active later in the degradation pathway.	Sulfhydryl Compounds	148-153	apolipoprotein B	Bos taurus	36-52
6112057-3	1981	At concentrations less than 10 mM, sodium nitrite required the addition of one of several thiols or ascorbate to activate guanylate cyclase from bovine coronary artery.	Sulfhydryl Compounds	90-96	guanylate cyclase	Bos taurus	122-139
6112057-4	1981	Guanylate cyclase activation by large amounts (50 microL) of saturated amyl nitrite gas did not require, but was enhanced by, the addition of thiols or ascorbate.	Sulfhydryl Compounds	142-148	guanylate cyclase	Bos taurus	0-17
6112057-5	1981	However, similar to sodium nitrite, guanylate cyclase activation by smaller amounts (5 microL) of saturated amyl nitrite gas did require the addition of one of various thiols or ascorbate.	Sulfhydryl Compounds	168-174	guanylate cyclase	Bos taurus	36-53
6272728-1	1981	A series of N-alkylmaleimides has been synthesized and used to investigate the thiol groups that are essential for the activity of rat liver microsomal glucose 6-phosphatase.	Sulfhydryl Compounds	79-84	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	152-173
6270905-3	1981	At the same time, activity of thiol-dependent enzymes/cathepsins B and C/ was decreased in all preparations studied.	Sulfhydryl Compounds	30-35	cathepsin B	Rattus norvegicus	54-72
7008829-0	1980	Determination of interactive thiol ionizations in bovine serum albumin, glutathione, and other thiols by potentiometric difference titration.	Sulfhydryl Compounds	29-34	albumin	Homo sapiens	57-70
7233443-7	1981	Since none of the main HCB-metabolites could induce a pathological porphyrin pattern, a reactive intermediate capable of reacting with glutathione or thiol-groups of uroporphyrinogen decarboxylase (UROG-D) is believed to be responsible for the inhibition of UROG-D.	Sulfhydryl Compounds	150-155	uroporphyrinogen decarboxylase	Gallus gallus	166-196
7233443-7	1981	Since none of the main HCB-metabolites could induce a pathological porphyrin pattern, a reactive intermediate capable of reacting with glutathione or thiol-groups of uroporphyrinogen decarboxylase (UROG-D) is believed to be responsible for the inhibition of UROG-D.	Sulfhydryl Compounds	150-155	uroporphyrinogen decarboxylase	Gallus gallus	198-204
6263263-3	1980	In the present study, we used the reactivity of sulphydryl groups in the Ca2+-dependent ATPase as an index of conformational change during the Ca2+ transport cycle and examined the effects of protein kinase-catalysed phosphorylation.	Sulfhydryl Compounds	48-58	dynein axonemal heavy chain 8	Homo sapiens	88-94
7008829-1	1980	A potentiometric difference titration (PDT) method is used to study the ionization behavior of the thiol group in bovine serum albumin and in the following less complex compounds: glutathione, cysteine, 2-mercaptoethanol, 3-mercaptopropionic acid, 2-mercaptoethylamine, cis-2-mercaptocyclobutylamine, 2-aminothiophenol, and 5-mercapto-2-nitrobenzoic acid.	Sulfhydryl Compounds	99-104	albumin	Homo sapiens	121-134
6263263-4	1980	N-Ethylmaleimide alkylation allowed the distinction of several thiol groups with variable functional significance for the ATPase.	Sulfhydryl Compounds	63-68	dynein axonemal heavy chain 8	Homo sapiens	122-128
6903192-12	1980	Conversion of C3 to C3b exposes one sulfhydryl residue as does modification of C3 with methylamine.	Sulfhydryl Compounds	36-46	complement C3	Homo sapiens	14-16
6263263-9	1980	The results indicate that protein kinase-catalysed phosphorylation results in conformational changes of the ATPase, which renders certain thiol groups inaccessible to N-ethylmaleimide.	Sulfhydryl Compounds	138-143	dynein axonemal heavy chain 8	Homo sapiens	108-114
6786284-3	1980	On assay of the reduction of ADP-Fe3+ chelate by the reduction of cytochrome c in the presence of superoxide dismutase and antimycin A or by the oxidation of reduced coenzymes, the reactions were not affected by rotenone but were inhibited by thiol-group inhibitors.	Sulfhydryl Compounds	243-248	LOC104968582	Bos taurus	66-78
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	Sulfhydryl Compounds	121-131	renin	Canis lupus familiaris	42-47
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	Sulfhydryl Compounds	121-131	renin	Canis lupus familiaris	110-115
7004725-2	1980	The low-molecular-weight (40 000) form of renin was converted into the high-molecular-weight (60 000) form of renin with sulphydryl oxidation, and the high-molecular-weight form of renin was re-converted into the low-molecular-weight form with a reduction of disulphide bonds in the renal cortical homogenate of the dog.	Sulfhydryl Compounds	121-131	renin	Canis lupus familiaris	110-115
7002370-0	1980	Enzyme immunoassay for insulin with a novel separation method using activated thiol-Sepharose.	Sulfhydryl Compounds	78-83	insulin	Homo sapiens	23-30
7430090-0	1980	A fluorescent probe study of Ca2+ binding to the Ca2+-specific sites of cardiac troponin and troponin C. Cardiac troponin C (C-TnC) was labeled with the sulfhydryl-specific fluorescent probe molecule 2-(4"-iodoacetamidoanilino)naphthalene-6-sulfonic acid at cysteine 35 and 84 to produce C-TnCIA.	Sulfhydryl Compounds	153-163	troponin C1, slow skeletal and cardiac type	Homo sapiens	105-130
7018481-3	1980	Conjugation of the insulin derivative to human placental alkaline phosphatase was carried out via a thiol interchange reaction and the resulting conjugate was active in a double-antibody, solid-phase enzyme immunoassay for insulin.	Sulfhydryl Compounds	100-105	insulin	Homo sapiens	19-26
6934510-1	1980	Treatment of the third component of human complement (C3) with methylamine results in a loss of hemolytic function and the appearance of a thiol group.	Sulfhydryl Compounds	139-144	complement C3	Homo sapiens	42-56
6903192-12	1980	Conversion of C3 to C3b exposes one sulfhydryl residue as does modification of C3 with methylamine.	Sulfhydryl Compounds	36-46	complement C3	Homo sapiens	20-23
6903192-12	1980	Conversion of C3 to C3b exposes one sulfhydryl residue as does modification of C3 with methylamine.	Sulfhydryl Compounds	36-46	complement C3	Homo sapiens	20-22
6251863-2	1980	These values are similar to those observed for reductions of oxidized glutathione and Ellman"s reagent by a similar set of thiols (beta nuc congruent to 0.5).	Sulfhydryl Compounds	123-129	nucleobindin 1	Homo sapiens	136-139
6447696-13	1980	These data indicating that pPDM does label the -SH1- and -SH2-containing region in myosin by covalently bridging them and shows that in the presence of MgADP these thiols can approach to within 12 to 14 A.	Sulfhydryl Compounds	164-170	myosin heavy chain 14	Homo sapiens	83-89
6249379-0	1980	Electron spin resonance study of human transcortin: Thiol groups and binding site topography.	Sulfhydryl Compounds	52-57	serpin family A member 6	Homo sapiens	39-50
7408902-2	1980	Trypsin has been reacted with dithiothreitol and with a naturally occurring thiol-containing trypsin inhibitor to form enzyme-inhibitor complexes.	Sulfhydryl Compounds	76-81	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	93-110
16661370-5	1980	The bean ABP auxin binding site is similar to the corn endoplasmic reticulum auxin-binding sites in specificity for auxins and sensitivity to thiol reagents and azide.	Sulfhydryl Compounds	142-147	auxin-binding protein 4	Zea mays	9-12
6252945-7	1980	In contrast to the situation in normal cells, sulphydryl groups in G-6-PD Espoo cells, and to a lesser extent in G-6-PD Helsinki cells, were sensitive to oxidation by acetylphenylhydrazine.	Sulfhydryl Compounds	46-56	glucose-6-phosphate dehydrogenase	Homo sapiens	67-73
6933551-2	1980	The effects of the drug on NADPH-thioredoxin oxidoreductase, EC 1.6.4.5] and thioredoxin-(SH)2, a ubiquitous thiol-dependent disulfide reductase system, are described.	Sulfhydryl Compounds	109-114	thioredoxin	Bos taurus	77-88
6105889-0	1980	Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols.	Sulfhydryl Compounds	15-21	guanylate cyclase	Bos taurus	58-75
6105889-1	1980	Glyceryl trinitrate specifically required cysteine, whereas NaNO2 at concentrations less than 10 mM required one of several thiols or ascorbate, to activate soluble guanylate cyclase from bovine coronary artery.	Sulfhydryl Compounds	124-130	guanylate cyclase	Bos taurus	165-182
6105889-5	1980	Similarly, micromolar concentrations of the S-nitroso derivatives of penicillamine, GSH and dithiothreitol, prepared by reacting the thiol with nitric oxide, activated guanylate cyclase.	Sulfhydryl Compounds	133-138	guanylate cyclase	Bos taurus	168-185
6105889-7	1980	Similarly, guanylate cyclase activation by glyceryl trinitrae plus cysteine, and by NaNO2 plus either a thiol or ascorbate, was inhibited by methemoglobin, ferricyanide and methylene blue.	Sulfhydryl Compounds	104-109	guanylate cyclase	Bos taurus	11-28
6821370-7	1980	A significant fraction of the protons in the whole molecule are affected by the binding of Co(II) at the first metal-ion-binding site (where the ligands are the enzyme"s sole thiol group and three histidine residues).	Sulfhydryl Compounds	175-180	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-97
7448199-10	1980	The activity of aminopeptidase A was not affected by sulfhydryl agents, S-S dissociating agents and serine proteinase inhibitor, but was inhibited strongly by metal chelating agents, and enhanced by alkaline earth metals.	Sulfhydryl Compounds	53-63	glutamyl aminopeptidase	Sus scrofa	16-32
7364505-1	1980	Albumin-collodion coated activated charcoal was found to effectively remove mercaptan in aqueous solution or in "plasma" solution.	Sulfhydryl Compounds	76-85	albumin	Homo sapiens	0-7
6772167-0	1980	Effects of phlorrhizin and thiol reagents on the galactosyltransferase activity of Golgi membrane vesicles of lactating rat mammary gland.	Sulfhydryl Compounds	27-32	glycoprotein alpha-galactosyltransferase 1	Rattus norvegicus	49-70
7391521-5	1980	Thiol compounds were required for the maximal enzyme activity and there was an absolute requirement for pyridoxal phosphate as a cofactor, with an apparent Km of 15 micro M. There was a modest competitive inhibition of ODC activity by the end products of ornithine catabolism.	Sulfhydryl Compounds	0-5	ornithine decarboxylase	Bos taurus	219-222
7396835-7	1980	This regeneration was diminished by the Ca2+-efflux stimulatig agents that were not themselves thiol-blocking reagents, such as thyroxine, uncoupler, trifluorothienylacetone and indomethacin.	Sulfhydryl Compounds	95-100	carbonic anhydrase 2	Homo sapiens	40-43
6446710-1	1980	Sarcoplasmic reticulum vesicles were exposed to various thiol-directed spin labels, and the position of the label on the inner or outer vesicle surface was investigated as a function of the ATPase (adenosinetriphosphatase; ATP phosphohydrolase, EC 3.6.1.3) chemical state.	Sulfhydryl Compounds	56-61	spindlin 1	Homo sapiens	71-75
7390984-8	1980	The number of thiol groups in order molecule of F1, F2, F3, and F4, was 4, 4, 4, and 5, respectively.	Sulfhydryl Compounds	14-19	prothrombin	Oryctolagus cuniculus	48-66
6444414-0	1980	Magnesium nucleotide is stoichiometrically trapped at the active site of myosin and its active proteolytic fragments by thiol cross-linking reagents.	Sulfhydryl Compounds	120-125	myosin heavy chain 14	Homo sapiens	73-79
6453130-1	1980	In isolated myosin the reaction sequence of essential thiol groups with N-ethylmaleimide was studied using the following five approaches: kinetics of the modification reaction, effects of modification on enzyme properties, affinity chromatography of isolated subfragment-1 stemming from modified myosin, isolation of cyanogen bromide peptides and identification of the tryptic thiol peptides thereof.	Sulfhydryl Compounds	54-59	myosin heavy chain 14	Homo sapiens	12-18
6453130-3	1980	In the former cases the two thiol-1 groups per myosin, one per active site, reacted at an equal rate indicating an equivalent microenvironment of these groups and hence a symmetric site-site relationship.	Sulfhydryl Compounds	28-33	myosin heavy chain 14	Homo sapiens	47-53
6243968-0	1980	Reactions of mercaptans with cytochrome c oxidase and cytochrome c.	Sulfhydryl Compounds	13-23	cytochrome c, somatic	Homo sapiens	29-41
7378066-12	1980	Modification of enzyme thiol groups during inactivation was determined by measuring a decrease in iodoacetamide-reactive groups in purified glucose 6-phosphate dehydrogenase.	Sulfhydryl Compounds	23-28	glucose-6-phosphate dehydrogenase	Rattus norvegicus	140-173
6243968-0	1980	Reactions of mercaptans with cytochrome c oxidase and cytochrome c.	Sulfhydryl Compounds	13-23	cytochrome c, somatic	Homo sapiens	54-66
7358630-3	1980	We studied the effect of Ca2+ on the reactivities of two SH groups of DTNB light chain (Cys 128 and Cys 157) using a fluorogenic thiol reagent.	Sulfhydryl Compounds	129-134	dystrobrevin beta	Homo sapiens	70-74
7358655-4	1980	Myosin was first treated with N-ethylmaleimide to block S1 and then treated with a fluorogenic thiol reagent, N-(7-dimethyl-amino-4-methylcoumarinyl) maleimide (DACM), in the presence or absence of ADP.	Sulfhydryl Compounds	95-100	myosin heavy chain 14	Homo sapiens	0-6
7358655-5	1980	From the distribution of DACM in the two kinds of DACM-treated myosin, it was found that thiol groups of all the light chains and of the 50 K fragment of subfragment-1 heavy chain became less reactive to DACM in the presence of ADP.	Sulfhydryl Compounds	89-94	myosin heavy chain 14	Homo sapiens	63-69
7358638-0	1980	Location of the essential thiol of porcine liver cathepsin B.	Sulfhydryl Compounds	26-31	cathepsin B	Homo sapiens	49-60
7358638-1	1980	Porcine liver cathepsin B, a thiol enzyme, exists in at least three forms.	Sulfhydryl Compounds	29-34	cathepsin B	Homo sapiens	14-25
120192-3	1979	CA III is liable to posttranslational modification by thiol group interaction.	Sulfhydryl Compounds	54-59	carbonic anhydrase 3	Homo sapiens	0-6
160564-1	1979	Particular thiols of the myosin subfragment 1 moieties of single glycerinated muscle fibers are covalently labeled with rhodamine.	Sulfhydryl Compounds	11-17	myosin heavy chain 14	Homo sapiens	25-31
226348-7	1979	These results indicate that sulfhydryl-binding reagents, through their interaction with critical thiol groups, promote insulin release in these insulinoma cells by inducing changes in calcium fluxes.	Sulfhydryl Compounds	28-38	insulin	Mesocricetus auratus	119-126
226348-7	1979	These results indicate that sulfhydryl-binding reagents, through their interaction with critical thiol groups, promote insulin release in these insulinoma cells by inducing changes in calcium fluxes.	Sulfhydryl Compounds	97-102	insulin	Mesocricetus auratus	119-126
226348-8	1979	It is possible that these thiol groups regulate calcium metabolism and, thus, insulin release under physiological conditions.	Sulfhydryl Compounds	26-31	insulin	Mesocricetus auratus	78-85
6111625-0	1980	Divalent cation dependent ATPase activities of red blood cell membranes: influence of the oxidation of membrane thiol groups close to each other.	Sulfhydryl Compounds	112-117	dynein axonemal heavy chain 8	Homo sapiens	26-32
6111625-3	1980	The oxidation of neighboring thiols seems to leave the mechanism of the (Ca2+ + Mg2+)-ATPase amplification system evoked by Ca2+ largely unaffected.	Sulfhydryl Compounds	29-35	dynein axonemal heavy chain 8	Homo sapiens	86-92
226348-0	1979	Sulfhydryl reagent-induced insulin release and 45Ca++ fluxes in Syrian hamster insulinoma cells.	Sulfhydryl Compounds	0-10	insulin	Mesocricetus auratus	27-34
540888-2	1979	S-GPT elevated due to ethionine (Eth) administration was suppressed by thiol compounds such as tiopronin (2-mercaptopropionylglycine), glutathione, cysteine, in which tiopronin proved to be more effective than glutathione or cysteine.	Sulfhydryl Compounds	71-76	glutamic--pyruvic transaminase	Homo sapiens	2-5
41666-5	1979	Renin was converted into a higher-molecular-weight form (60 000) by mixing with cytosol in the presence of sodium tetrathionate, a thiol inhibitor.	Sulfhydryl Compounds	131-136	renin	Canis lupus familiaris	0-5
486501-0	1979	The role of zinc with special reference to the essential thiol groups in delta-aminolevulinic acid dehydratase of bovine liver.	Sulfhydryl Compounds	57-62	aminolevulinate dehydratase	Bos taurus	73-110
160508-10	1979	The thiol reagents, N-ethylmaleimide and para-chloromercuribenzoate (PCMB), affected the ATPase activity and the phosphoryl transfer activity differently: with the blockade of 2.4 essential thiol equivalents by N-ethylmaleimide the ATPase was inhibited 50% and net uptake of catecholamine ceased, while the phosphoryl transfer remained unimpaired.	Sulfhydryl Compounds	4-9	dynein axonemal heavy chain 8	Homo sapiens	89-95
160508-10	1979	The thiol reagents, N-ethylmaleimide and para-chloromercuribenzoate (PCMB), affected the ATPase activity and the phosphoryl transfer activity differently: with the blockade of 2.4 essential thiol equivalents by N-ethylmaleimide the ATPase was inhibited 50% and net uptake of catecholamine ceased, while the phosphoryl transfer remained unimpaired.	Sulfhydryl Compounds	4-9	dynein axonemal heavy chain 8	Homo sapiens	232-238
160508-10	1979	The thiol reagents, N-ethylmaleimide and para-chloromercuribenzoate (PCMB), affected the ATPase activity and the phosphoryl transfer activity differently: with the blockade of 2.4 essential thiol equivalents by N-ethylmaleimide the ATPase was inhibited 50% and net uptake of catecholamine ceased, while the phosphoryl transfer remained unimpaired.	Sulfhydryl Compounds	190-195	dynein axonemal heavy chain 8	Homo sapiens	89-95
160508-10	1979	The thiol reagents, N-ethylmaleimide and para-chloromercuribenzoate (PCMB), affected the ATPase activity and the phosphoryl transfer activity differently: with the blockade of 2.4 essential thiol equivalents by N-ethylmaleimide the ATPase was inhibited 50% and net uptake of catecholamine ceased, while the phosphoryl transfer remained unimpaired.	Sulfhydryl Compounds	190-195	dynein axonemal heavy chain 8	Homo sapiens	232-238
159451-1	1979	Studies with reagents that crosslink two thiol groups have shown that it is possible to trap nucleotides at the active site of myosin chymotryptic subfragment 1.	Sulfhydryl Compounds	41-46	myosin heavy chain 14	Homo sapiens	127-133
120298-8	1979	These thiol compounds did not influence fp1 and fp2 but tended to suppress the cytochrome P-450 content decreased by administration of ethionine.	Sulfhydryl Compounds	6-11	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	79-95
468832-0	1979	Interchangeable forms of thiol:protein disulfide oxidoreductase.	Sulfhydryl Compounds	25-30	thioredoxin reductase 1	Homo sapiens	49-63
91367-17	1979	S-alpha 2M was readily dissociated to the quarter-subunits by mild reduction, with the formation of 3-4 new thiol groups per subunit.	Sulfhydryl Compounds	108-113	alpha-2-macroglobulin	Homo sapiens	2-10
501902-2	1979	High molecular weight (HMW) renin fractionated by gel chromatography from crude renal extract prepared with thiol group blockers was converted into normal size renin by acdification, accompanied with an increase in renin activity by about 50%.	Sulfhydryl Compounds	108-113	renin	Canis lupus familiaris	28-33
501902-2	1979	High molecular weight (HMW) renin fractionated by gel chromatography from crude renal extract prepared with thiol group blockers was converted into normal size renin by acdification, accompanied with an increase in renin activity by about 50%.	Sulfhydryl Compounds	108-113	renin	Canis lupus familiaris	160-165
501902-2	1979	High molecular weight (HMW) renin fractionated by gel chromatography from crude renal extract prepared with thiol group blockers was converted into normal size renin by acdification, accompanied with an increase in renin activity by about 50%.	Sulfhydryl Compounds	108-113	renin	Canis lupus familiaris	160-165
501902-4	1979	Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.	Sulfhydryl Compounds	96-101	renin	Canis lupus familiaris	0-5
501902-4	1979	Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.	Sulfhydryl Compounds	96-101	renin	Canis lupus familiaris	10-15
501902-4	1979	Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.	Sulfhydryl Compounds	96-101	renin	Canis lupus familiaris	57-62
501902-4	1979	Renin and renin binding substance could combine into HMW renin at neutral pH in the presence of thiol group blockers and renin activity decreased.	Sulfhydryl Compounds	96-101	renin	Canis lupus familiaris	57-62
110443-7	1979	Both V79 and Ehrlich cells contained appreciable amounts of glutathione S-transferase (EC 2.5.1.18), which catalyzes the nucleophilic substitution of the nitro group of 4-NQO with thiols.	Sulfhydryl Compounds	180-186	hematopoietic prostaglandin D synthase	Mus musculus	60-85
540885-9	1979	In the experiment on the therapeutic effects, the maximal values of serum GOT and GPT brought by ethionine were suppressed by the thiol compounds given 16 hr after ethionine administration, but liver NPSH content and liver lipids were not influenced.	Sulfhydryl Compounds	130-135	glutamic--pyruvic transaminase	Rattus norvegicus	82-85
91367-20	1979	If the thiol groups of the quarter-subunits of S-alpha 2M were blocked by carboxymethylation, oxidative reassociation did not occur.	Sulfhydryl Compounds	7-12	alpha-2-macroglobulin	Homo sapiens	49-57
36318-0	1979	Effect of leucine on the pyridine nucleotide contents of islets and on the insulin released--interactions in vitro with methylene blue, thiol oxidants, and p-chloromercuribenzoate.	Sulfhydryl Compounds	136-141	insulin	Homo sapiens	75-82
232052-4	1979	CCl4 induced a significant decrease of nonprotein thiol (NPSH) in the liver 24 hr after administration, but this decrease did not result in an increase of nonprotein disulfide in the liver.	Sulfhydryl Compounds	50-55	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
39555-3	1979	The l-glutamine-dependent l-asparagine synthetase activity of the partially purified enzyme from mouse pancreas was markedly decreased by freezing for 7 days at -87 degrees C in the presence of 1mm-dithiothreitol, but effectively protected from inactivation by high concentrations (10mm) of the thiol reagent.	Sulfhydryl Compounds	295-300	asparagine synthetase	Mus musculus	28-49
36318-8	1979	From the data, we assume that the observed increase of NADPH may lead via GSH to an increase in the number of such thiol groups in the beta-cell membrane, which are believed to be related to stimulation of insulin release and, thus, to increase the sensitivity of the beta-cell to stimulation by glucose and/or leucine.	Sulfhydryl Compounds	115-120	insulin	Homo sapiens	206-213
379020-2	1979	The lectins are all thiol group-requiring, divalent cation-independent dimers, of apparent monomer mol wt 12,000 (calf lectins) or 13,000 (chicken lectin), and acidic pI.	Sulfhydryl Compounds	20-25	galectin 3	Gallus gallus	4-10
117842-0	1979	Proteolytic fragmentation of myosin: location of SH-1 and SH-2 thiols.	Sulfhydryl Compounds	63-69	myosin heavy chain 14	Homo sapiens	29-35
34612-0	1979	Interaction of lactoperoxidase with thiols and diiodotyrosine.	Sulfhydryl Compounds	36-42	lactoperoxidase	Homo sapiens	15-30
34612-7	1979	Lactoperoxidase is also adsorbed on insolubilized thiols (thiol-agarose).	Sulfhydryl Compounds	50-56	lactoperoxidase	Homo sapiens	0-15
34612-7	1979	Lactoperoxidase is also adsorbed on insolubilized thiols (thiol-agarose).	Sulfhydryl Compounds	50-55	lactoperoxidase	Homo sapiens	0-15
34612-9	1979	A simple method for the preparation of lactoperoxidase from milk by affinity chromatography is based on the interactions of the enzyme with the two ligands, thiols and diiodotyrosine.	Sulfhydryl Compounds	157-163	lactoperoxidase	Homo sapiens	39-54
162124-4	1979	These results indicate that the perturbation of the ATPase microenvironment caused by membrane thiol oxidation is at good extent responsible for alterations of the divalent cation-dependent ATPase activity.	Sulfhydryl Compounds	95-100	dynein axonemal heavy chain 8	Homo sapiens	52-58
162124-4	1979	These results indicate that the perturbation of the ATPase microenvironment caused by membrane thiol oxidation is at good extent responsible for alterations of the divalent cation-dependent ATPase activity.	Sulfhydryl Compounds	95-100	dynein axonemal heavy chain 8	Homo sapiens	190-196
229680-2	1979	When alcohol or thiol ligands are added to the sixth coordination position of a five-coordinated 4-nitrobenzene thiolate complex of FeIII protoporphyrin IX dimethyl ester chloride low spin complexes with optical and EPR-spectra very similar to cytochrome P-450 are obtained.	Sulfhydryl Compounds	16-21	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	244-260
537258-6	1979	Sulfhydryl inhibitors such as ethacrynic acid, mersalyl and p-chloromercuribenzoic acid suppressed Ca2+ efflux and stimulated Ca2+ influx.	Sulfhydryl Compounds	0-10	carbonic anhydrase 2	Rattus norvegicus	99-102
537258-6	1979	Sulfhydryl inhibitors such as ethacrynic acid, mersalyl and p-chloromercuribenzoic acid suppressed Ca2+ efflux and stimulated Ca2+ influx.	Sulfhydryl Compounds	0-10	carbonic anhydrase 2	Rattus norvegicus	126-129
512360-4	1979	The haptoglobin-hemoglobin complexes are then specifically eluted by buffers containing dithiothreitol or other thiols and are further purified by chromatography on concanavalin A-agarose and Sephacryl S-200 columns.	Sulfhydryl Compounds	112-118	haptoglobin	Homo sapiens	4-15
318410-2	1979	The cholesterol esterifying activity in mouse plasma has been identified as lecithin:cholesterol acyltransferase (LCAT) on the basis of stoichiometric data, predominant transfer of polyunsaturated fatty acids, wide pH optimum and inhibition of esterification by phospholipase A2 and sulphydryl blocking agents.	Sulfhydryl Compounds	283-293	lecithin cholesterol acyltransferase	Mus musculus	76-112
318410-2	1979	The cholesterol esterifying activity in mouse plasma has been identified as lecithin:cholesterol acyltransferase (LCAT) on the basis of stoichiometric data, predominant transfer of polyunsaturated fatty acids, wide pH optimum and inhibition of esterification by phospholipase A2 and sulphydryl blocking agents.	Sulfhydryl Compounds	283-293	lecithin cholesterol acyltransferase	Mus musculus	114-118
422323-3	1979	Conversion of the latter into the sulfhydryl form and interaction with the S-sulfonated B chain of bovine (sheep) insulin yielded [Arg21-A] sheep insulin, which was purified by chromatography on a carboxymethylcellulose column with an exponential sodium chloride gradient.	Sulfhydryl Compounds	34-44	LOC105613195	Ovis aries	146-153
728403-1	1978	The highly purified form of phosphoenolpyruvate carboxykinase (PEPCK) contained 13 thiols (all in the reduced state) per 72 000 daltons.	Sulfhydryl Compounds	83-89	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	28-61
728403-1	1978	The highly purified form of phosphoenolpyruvate carboxykinase (PEPCK) contained 13 thiols (all in the reduced state) per 72 000 daltons.	Sulfhydryl Compounds	83-89	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	63-68
152313-1	1978	The fluorescent reagent, S-mercuric N-dansyl-cysteine, reacts specifically with thiols of the purified Ca2+-ATPase of the sarcoplasmic reticulum, producing an increase of fluorescence of fluorescence intensity at 500 nm (lambda ex = 335 nm).	Sulfhydryl Compounds	80-86	dynein axonemal heavy chain 8	Homo sapiens	108-114
152313-3	1978	Twelve reactive thiols per 10(5) daltons of ATPase peptide fall into roughly three classes.	Sulfhydryl Compounds	16-22	dynein axonemal heavy chain 8	Homo sapiens	44-50
701259-5	1978	Radish cytochrome f contains one thiol group which reacts with 5,5"-dithiobis(2-nitrobenzoic acid) only after denaturation by sodium dodecyl sulfate.	Sulfhydryl Compounds	33-38	petA	Raphanus sativus	7-19
681358-8	1978	Model reactions between 8-Cl-Flavin (riboflavin or FAD) and organic thiols (thiophenol, beta-mercaptoethanol, or N-acetylcysteine) give products with spectra which are similar to that of FAD covalently bound to lipoamide dehydrogenase.	Sulfhydryl Compounds	68-74	dihydrolipoamide dehydrogenase	Homo sapiens	211-234
747665-4	1978	Though the molecular weight of renin in kidney-cortex homogenate was 43,000, it was completely converted into high-molecular-weight renin in the presence of substances that react with thiol groups.	Sulfhydryl Compounds	184-189	renin	Canis lupus familiaris	31-36
747665-4	1978	Though the molecular weight of renin in kidney-cortex homogenate was 43,000, it was completely converted into high-molecular-weight renin in the presence of substances that react with thiol groups.	Sulfhydryl Compounds	184-189	renin	Canis lupus familiaris	132-137
738998-0	1978	Formation of interchain disulfide bonds in Bence Jones proteins and Fab(t) fragments of immunoglobulin G through thiol-disulfide interchange.	Sulfhydryl Compounds	113-118	FA complementation group B	Homo sapiens	68-71
718919-3	1978	The results in this report demonstrate that dithiothreitol, which stabilizes thiol groups, will, like hemin, prevent the conversion of the prorepressor to HCR and will inactivate reversible HCR.	Sulfhydryl Compounds	77-82	eukaryotic translation initiation factor 2-alpha kinase 1	Oryctolagus cuniculus	155-158
718919-3	1978	The results in this report demonstrate that dithiothreitol, which stabilizes thiol groups, will, like hemin, prevent the conversion of the prorepressor to HCR and will inactivate reversible HCR.	Sulfhydryl Compounds	77-82	eukaryotic translation initiation factor 2-alpha kinase 1	Oryctolagus cuniculus	190-193
208787-0	1978	A model of cytochrome P-450; optical and EPR properties of a thiol-containing peptide-hemin system and its activity of aniline hydroxylation.	Sulfhydryl Compounds	61-66	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	11-27
697744-1	1978	6,6-Dithiodinicotinate shows half-of-the-sites reactivity towards the six catalytic-site thiol groups of bovine liver UDP-glucose dehydrogenase.	Sulfhydryl Compounds	89-94	UDP-glucose 6-dehydrogenase	Bos taurus	118-143
684756-3	1978	The activity of glyceraldehyde-3-phosphate dehydrogenase was inhibited by blocking thiol-groups with the mercury compounds.	Sulfhydryl Compounds	83-88	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	16-56
684756-7	1978	Thioltransferase, known to catalyze thiol-disulfide exchange reactions, increased the regain of glyceraldehyde-3-phosphate dehydrogenase activity to nearly the original value.	Sulfhydryl Compounds	36-41	glutaredoxin	Homo sapiens	0-16
684756-7	1978	Thioltransferase, known to catalyze thiol-disulfide exchange reactions, increased the regain of glyceraldehyde-3-phosphate dehydrogenase activity to nearly the original value.	Sulfhydryl Compounds	36-41	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	96-136
566268-0	1978	Ionization and reactivities of the thiol groups which participate in the formation of interchain disulfide bonds of Bence Jones proteins and an Fab(t) fragment.	Sulfhydryl Compounds	35-40	FA complementation group B	Homo sapiens	144-147
566268-1	1978	The pK values and reactivities of the thiol groups which participate in the formation of interchain disulfide bonds in Bence Jones proteins and the Fab(t) fragment of a myeloma protein (Jo) (IgGl, kappa) were determined by means of the reactions with chloroacetamide and DTNB, and of spectrophotometric titration.	Sulfhydryl Compounds	38-43	dystrobrevin beta	Homo sapiens	271-275
566268-5	1978	The spectrophotometric titration of partially reduced Nag protein (type lambda) also showed that the two thiol groups have different pK values.	Sulfhydryl Compounds	105-110	NBAS subunit of NRZ tethering complex	Homo sapiens	54-57
30408-0	1978	Characterization, kinetics and comparative properties of thiol:protein disulfide oxidoreductase.	Sulfhydryl Compounds	57-62	thioredoxin reductase 1	Homo sapiens	81-95
680802-6	1978	Variation of the L-cystine content of the medium used here influenced the effect of thiols such as D-PAm on the cells, an increase in cystine content favouring the retention of high activity.	Sulfhydryl Compounds	84-90	peptidylglycine alpha-amidating monooxygenase	Mus musculus	101-104
35747-4	1978	Moreover, a high initial rise is observed in cathepsin B1, a thiol-dependent endopeptidase of lysosomes, and in dipeptidyl peptidase IV, a membrane-associated peptidase.	Sulfhydryl Compounds	61-66	cathepsin B	Homo sapiens	45-57
207651-1	1978	The yields in molecules per 100 eV for active-site and sulphydryl loss from glyceraldehyde-3-phosphate dehydrogenase have been determined in nitrous-oxide-saturated, aerated and argon-saturated solutions.	Sulfhydryl Compounds	55-65	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	76-116
212908-3	1978	The inactivation of (NaK)-ATPase by reaction with NBD-chloride showing under all conditions studied a pseudo first-order rate rests on the alkylation of thiol groups in or near catalytic centre.	Sulfhydryl Compounds	153-158	TANK binding kinase 1	Homo sapiens	21-24
348469-1	1978	The single thiol of yeast phosphoglycerate kinase was labelled with the chromophoric sulfhydryl reagent, 2-chloromercuri-4-nitrophenol.	Sulfhydryl Compounds	11-16	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	26-49
348469-8	1978	Anions bound to phosphoglycerate kinase decreased the rate of reaction between the enzyme thiol and 5,5"-dithiobis(2-nitrobenzoic acid).	Sulfhydryl Compounds	90-95	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	16-39
646820-0	1978	A study of the role of the reactive thiol group of rabbit muscle creatine kinase with a chromophoric reporter group.	Sulfhydryl Compounds	36-41	creatine kinase M-type	Oryctolagus cuniculus	58-80
646820-1	1978	Substrate- and ligand-induced conformational changes were studied in a series of thiol-modified derivatives of rabbit muscle creatine kinase that retained different amounts of enzymic activity.	Sulfhydryl Compounds	81-86	creatine kinase M-type	Oryctolagus cuniculus	118-140
304805-2	1978	alpha1-Antitrypsin contains a single thiol group partly blocked in native plasma and reactive after mild reduction.	Sulfhydryl Compounds	37-42	serpin family A member 1	Homo sapiens	0-18
339944-0	1978	Hydrolytically induced allosteric change in the heavy chain of intact myosin involving nonessential thiol groups.	Sulfhydryl Compounds	100-105	myosin heavy chain 14	Homo sapiens	70-76
339944-3	1978	In intact myosin nonessential thiol 3 groups become the most reactive during ATP hydrolysis above 15 degrees C. These thiol 3 groups are located in a portion of the myosin heavy chain which appears as a fragment with an apparent molecular weight of 11 000 during proteolysis.	Sulfhydryl Compounds	30-35	myosin heavy chain 14	Homo sapiens	10-16
339944-3	1978	In intact myosin nonessential thiol 3 groups become the most reactive during ATP hydrolysis above 15 degrees C. These thiol 3 groups are located in a portion of the myosin heavy chain which appears as a fragment with an apparent molecular weight of 11 000 during proteolysis.	Sulfhydryl Compounds	30-35	myosin heavy chain 14	Homo sapiens	165-171
339944-3	1978	In intact myosin nonessential thiol 3 groups become the most reactive during ATP hydrolysis above 15 degrees C. These thiol 3 groups are located in a portion of the myosin heavy chain which appears as a fragment with an apparent molecular weight of 11 000 during proteolysis.	Sulfhydryl Compounds	118-123	myosin heavy chain 14	Homo sapiens	10-16
339944-3	1978	In intact myosin nonessential thiol 3 groups become the most reactive during ATP hydrolysis above 15 degrees C. These thiol 3 groups are located in a portion of the myosin heavy chain which appears as a fragment with an apparent molecular weight of 11 000 during proteolysis.	Sulfhydryl Compounds	118-123	myosin heavy chain 14	Homo sapiens	165-171
339944-6	1978	As its nonessential thiol 3 groups are rendered the most reactive of all thiol groups in the enzyme-product complex M**ADP.Pi, the hydrolytic step induces an allosteric conformational change in the neck region of intact myosin.	Sulfhydryl Compounds	20-25	myosin heavy chain 14	Homo sapiens	220-226
339944-6	1978	As its nonessential thiol 3 groups are rendered the most reactive of all thiol groups in the enzyme-product complex M**ADP.Pi, the hydrolytic step induces an allosteric conformational change in the neck region of intact myosin.	Sulfhydryl Compounds	73-78	myosin heavy chain 14	Homo sapiens	220-226
212908-12	1978	In the absence of ATP, Na+ or K+ ligandation of (NaK)-ATPase produce opposite effects on the reactivity of the thiol groups of catalytic centres reflecting different changes of their conformation.	Sulfhydryl Compounds	111-116	TANK binding kinase 1	Homo sapiens	49-52
723265-2	1978	Both control and insulin-stimulated D-glucose transport activities were inhibited by cytochalasin B and thiol reagents.	Sulfhydryl Compounds	104-109	insulin	Homo sapiens	17-24
623821-2	1978	In case of Mg-ATP and unmodified myosin conformation of the active centre changes monotonously with the change in temperature but after the modification of S1 thiol groups by N-ethylmaleimide on the temperature dependence curve of rotational mobility of the spin label a discontinuous is observed at 14-16 degrees C. It is also observed in case of K+-EDTA-ATP, or Ca2+-ATP and unmodified myosin.	Sulfhydryl Compounds	159-164	myosin heavy chain 14	Homo sapiens	33-39
623821-2	1978	In case of Mg-ATP and unmodified myosin conformation of the active centre changes monotonously with the change in temperature but after the modification of S1 thiol groups by N-ethylmaleimide on the temperature dependence curve of rotational mobility of the spin label a discontinuous is observed at 14-16 degrees C. It is also observed in case of K+-EDTA-ATP, or Ca2+-ATP and unmodified myosin.	Sulfhydryl Compounds	159-164	myosin heavy chain 14	Homo sapiens	388-394
337969-1	1977	The effects of urea in concentrations from 0 to 6M on the following properties of yeast phosphoglycerate kinase were studied: the kinetics of inactivation of the enzyme, the spectrum of 2-chloromercuri-4-nitrophenol bound to the single thiol group of the enzyme, the rate of reaction between the mercurial and enzyme, and the isoelectric point.	Sulfhydryl Compounds	236-241	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	88-111
909062-0	1977	The interaction of ethacrynic acid, dihydroethacrynic acid and certain thiol adducts of ethacrynic acid with bovine serum albumin.	Sulfhydryl Compounds	71-76	albumin	Homo sapiens	116-129
144520-0	1977	Reactivity of essential thiols of myosin.	Sulfhydryl Compounds	24-30	myosin heavy chain 14	Homo sapiens	34-40
144520-4	1977	The binding of MgADP to myosin exposes the essential thiols as reflected by an increased rate of their modification.	Sulfhydryl Compounds	53-59	myosin heavy chain 14	Homo sapiens	24-30
144610-0	1977	Isolation of cyanogen bromide and tryptic peptides containing the essential thiol groups from isolated myosin heads.	Sulfhydryl Compounds	76-81	myosin heavy chain 14	Homo sapiens	103-109
903355-1	1977	A thiol:protein disulfide oxidoreductase which degrades insulin into its A and B chains has been purified to homogeneity from bovine liver.	Sulfhydryl Compounds	2-7	insulin	Bos taurus	56-63
891549-7	1977	Sterically unhindered thiol groups in the rat hemoglobin are thought to react with the usual adduct intermediate in GSH oxidation by diazene (formed from RCON = NCOR + GSH leads to RCON(SG)NHCOR) to produce mixed disulfides, from which GSH is not easily regenerated.	Sulfhydryl Compounds	22-27	nuclear receptor co-repressor 1	Rattus norvegicus	161-165
200608-1	1977	Fragmented sarcoplasmic reticulum (SR) was reacted with a thiol-directed spin label, N-(1-oxyl-2,2,6,6,-tetramethyl-4-piperidinyl)maleimide, under various conditions.	Sulfhydryl Compounds	58-63	spindlin 1	Homo sapiens	73-77
332226-0	1977	Evidence for a single essential thiol in the yeast hexokinase molecule.	Sulfhydryl Compounds	32-37	hexokinase	Saccharomyces cerevisiae S288C	51-61
332226-1	1977	In yeast hexokinase B, two thiols per monomer appeared to be essential when enzymic inactivation was produced by the concurrent alkylation of both of them, by several reagents including the affinity reagent N-bromoacetyl-2-D-galactosamine.	Sulfhydryl Compounds	27-33	hexokinase	Saccharomyces cerevisiae S288C	9-19
560871-1	1977	A bovine counterpart to human prealbumin was purified from bovine serum by thiol-disulfide exchange chromatography on thiol-Sepharose 4B and affinity chromatography on human retinol-binding protein linked to Sepharose 4B.	Sulfhydryl Compounds	75-80	transthyretin	Bos taurus	30-40
560871-1	1977	A bovine counterpart to human prealbumin was purified from bovine serum by thiol-disulfide exchange chromatography on thiol-Sepharose 4B and affinity chromatography on human retinol-binding protein linked to Sepharose 4B.	Sulfhydryl Compounds	118-123	transthyretin	Bos taurus	30-40
193485-7	1977	When a nucleotide is bound, the 2 heads of a single myosin molecule adopt different conformations since on each head a different type of essential thiol group was found to be the most reactive towards N-ethylmaleimide.	Sulfhydryl Compounds	147-152	myosin heavy chain 14	Homo sapiens	52-58
894267-1	1977	Fibroblast interferon may be stabilized against many inactivating influences by the addition of certain simple sulphydryl reagents.	Sulfhydryl Compounds	111-121	interferon beta 1	Homo sapiens	0-21
18114-0	1977	Reaction of brain hexokinase with tetranitromethane: oxidation of essential thiol groups.	Sulfhydryl Compounds	76-81	hexokinase 1	Homo sapiens	18-28
141279-3	1977	subunit of skeletal-muscle phosphofructokinase was specifically carboxymethylated with iodo[2-14C]acetate, and after denaturation the remaining thiol groups were carboxymethylated with bromo[2-3H]acetate.	Sulfhydryl Compounds	144-149	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	27-46
16004-1	1977	Rat liver ornithine decarboxylase induced by injection of thioacetamide has been separated into at least two fractions by covalent chromatography on an activated thiol-Sepharose 4B column.	Sulfhydryl Compounds	162-167	ornithine decarboxylase 1	Rattus norvegicus	10-33
843346-0	1977	Primary structure of the essential thiol peptide from the lactate dehydrogenase C subunit.	Sulfhydryl Compounds	35-40	lactate dehydrogenase C	Homo sapiens	58-81
16877-3	1977	As previously reported when a specific thiol group, S2, of myosin reacts with N-ethylmaleimide (NEM), its Ca2+-ATPase activity is decreased.	Sulfhydryl Compounds	39-44	myosin heavy chain 14	Homo sapiens	59-65
902911-0	1977	Effects of temperature and reagent size on the reaction of the thiol groups of rabbit muscle creatine kinase [proceedings].	Sulfhydryl Compounds	63-68	creatine kinase M-type	Oryctolagus cuniculus	86-108
188546-1	1977	The S-adenosylmethionine synthetase activities of rat liver and Novikoff ascites tumor have been partially purified and characterized by chromatographic behavior, kinetic analysis, sulfhydryl dependency, and response to inhibitors.	Sulfhydryl Compounds	181-191	methionine adenosyltransferase 1A	Rattus norvegicus	4-35
906730-2	1977	Cathepsin H is an endoaminopeptidase belonging to the group of thiol enzymes.	Sulfhydryl Compounds	63-68	cathepsin H	Rattus norvegicus	0-11
963021-4	1976	Combination of this compound with the sulfhydryl form of human A chain afforded [Leu9-B]insulin.	Sulfhydryl Compounds	38-48	insulin	Homo sapiens	88-95
22044-2	1977	Behavior of sulfhydryl and disulfide groups in alkali-treated beta-lactoglobulin and alpha-lactalbumin].	Sulfhydryl Compounds	12-22	lactalbumin alpha	Homo sapiens	85-102
857407-4	1977	The effect of insulin on the hexokinase activity was postulated to occur due to reaction of thiol-disulphide exchange between disulphide group of insulin and free sulfhydryl group of hexokinase.	Sulfhydryl Compounds	92-97	insulin	Homo sapiens	14-21
857407-4	1977	The effect of insulin on the hexokinase activity was postulated to occur due to reaction of thiol-disulphide exchange between disulphide group of insulin and free sulfhydryl group of hexokinase.	Sulfhydryl Compounds	92-97	insulin	Homo sapiens	146-153
1000490-6	1976	In addition, those enzymes that have been demonstrated to be most sensitive to established sulfhydryl inhibitors, such as glyceraldehyde-3-phosphate dehydrogenase, were also most sensitive to rhodium(II) carboxylate inactivation.	Sulfhydryl Compounds	91-101	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	122-162
1034635-0	1976	Current status of the thiol redox model for the regulation of hexose transport by insulin.	Sulfhydryl Compounds	22-27	insulin	Homo sapiens	82-89
1034635-1	1976	Data obtained over the last two years pertinent to the thiol redox model for the modulation of hexose transport activity by insulin is summarized.	Sulfhydryl Compounds	55-60	insulin	Homo sapiens	124-131
990916-2	1976	At 20 degrees C, DIP was as fast as the thiol oxidizing agent, diamide, in evoking transmitter release but was appreciably less effective at 6 degrees C. DIP + 1 and DIP + 2 did not increase transmitter release.	Sulfhydryl Compounds	40-45	DIP	Homo sapiens	17-20
402003-1	1977	A variety of thiol compounds inhibited the enzymatic bis-oxygenation of 8,11,14-eicosatrienoic acid to prostaglandin G1, as examined with a purified preparation of prostaglandin endoperoxide synthetase (prostaglandin synthase; 8,11,14-eicosatrienoate, hydrogen-donor:oxygen oxidoreductase; EC 1.14.99.1) from bovine vesicular gland.	Sulfhydryl Compounds	13-18	thioredoxin reductase 1	Homo sapiens	274-288
1009954-1	1976	Reaction of the thiol reagent 5,5"-dithio-bis(2-nitrobenzoic acid) (Nbs2) with the brain-specific protein S-100 favours stabilization of the quaternary structure of the protein via disulfide bond formation.	Sulfhydryl Compounds	16-21	S100 calcium binding protein B	Homo sapiens	106-111
1009954-4	1976	These findings are interpreted assuming that in presence of Ca2+ the three subunits forming the native S-100 protein have two cysteine residues exposed to the solvent but mismatched to form disulfides while in presence of K+ the sulphydryl groups are in a less accessible position to Nbs2 but suitable for S-S bond formation.	Sulfhydryl Compounds	229-239	S100 calcium binding protein B	Homo sapiens	103-108
1009944-1	1976	The two reactive thiol groups of rabbit muscle creatine kinase were stoichiometrically reacted with 5,5"-dithio-bis(2-nitrobenzoic acid).	Sulfhydryl Compounds	17-22	creatine kinase M-type	Oryctolagus cuniculus	40-62
135584-1	1976	"Substrate inhibition", which has been described earlier for myosin Ca-ATPase in low ionic strength KCl solution [1], is found to take place also at high KCl concentration and under partial modification of enzyme thiol groups with p-CMB.	Sulfhydryl Compounds	213-218	myosin heavy chain 14	Homo sapiens	61-67
9375-0	1976	Thiols of myosin.	Sulfhydryl Compounds	0-6	myosin heavy chain 14	Homo sapiens	10-16
1085169-1	1976	alpha 1-Antitrypsin phenotypes Pi M and Z, purified by the thiol-disulfide exchange procedure, were desialylated by treatment with neuraminidase covalently coupled to Sepharose and used as acceptors of sialic acid in an assay system for serum sialic acid transferase (CMP-N-acetylneuraminate:D-galactosyl-glycoprotein N-acetylneuraminyltransferase, EC 2.4.99.1) activity.	Sulfhydryl Compounds	59-64	serpin family A member 1	Homo sapiens	0-19
133635-0	1976	Defining the "fast-reacting" thiols of myosin by reaction with 1, 5 IAEDANS.	Sulfhydryl Compounds	29-35	myosin heavy chain 14	Homo sapiens	39-45
182393-0	1976	Binding of thiols to microsomal cytochrome P-450.	Sulfhydryl Compounds	11-17	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	32-48
182393-6	1976	Tertiary thiols caused the formation of the high-spin cytochrome P-450 substrate complex, and model studies with myoglobin revealed that steric hindrance prevented the liganding of the tertiary thiol group to the ferric cytochrome P-450.	Sulfhydryl Compounds	9-15	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	54-70
182393-6	1976	Tertiary thiols caused the formation of the high-spin cytochrome P-450 substrate complex, and model studies with myoglobin revealed that steric hindrance prevented the liganding of the tertiary thiol group to the ferric cytochrome P-450.	Sulfhydryl Compounds	9-15	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	220-236
182393-6	1976	Tertiary thiols caused the formation of the high-spin cytochrome P-450 substrate complex, and model studies with myoglobin revealed that steric hindrance prevented the liganding of the tertiary thiol group to the ferric cytochrome P-450.	Sulfhydryl Compounds	9-14	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	54-70
182393-6	1976	Tertiary thiols caused the formation of the high-spin cytochrome P-450 substrate complex, and model studies with myoglobin revealed that steric hindrance prevented the liganding of the tertiary thiol group to the ferric cytochrome P-450.	Sulfhydryl Compounds	9-14	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	220-236
182393-8	1976	It was concluded that lipophilic thiols can be bound as ligands by at least two species of oxidized cytochrome P-450 which represent, however, not more than about one fifth of the total cytochrome P-450 content in liver microsomes from phenobarbital-pretreated rats.	Sulfhydryl Compounds	33-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	100-116
182393-8	1976	It was concluded that lipophilic thiols can be bound as ligands by at least two species of oxidized cytochrome P-450 which represent, however, not more than about one fifth of the total cytochrome P-450 content in liver microsomes from phenobarbital-pretreated rats.	Sulfhydryl Compounds	33-39	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	186-202
9375-3	1976	The flexibility of the tertiary structure around the active site of myosin ATPase [EC 3.6.1.3] was studied using the reactivity of two specific thiol groups, S1 and S2, as a structural probe.	Sulfhydryl Compounds	144-149	myosin heavy chain 14	Homo sapiens	68-74
775317-1	1976	Treatment of elongation factor G (EF-G) with the thiol reagent N-ethylmaleimide only partially inhibits (10 to 70%) the activity of the factor in (a) guanosine nucleotide-EF-G-ribosome complex formation, (b) uncoupled ribosome-dependent GTP hydrolysis, and (c) polypeptide synthesis.	Sulfhydryl Compounds	49-54	G elongation factor mitochondrial 1	Homo sapiens	13-32
776964-2	1976	Native tryptophanyl-tRNA synthetase purified from Escherichia coli B has on each identical subunit a single thiol group which rapidly forms a mixed disulfide with a thionitrobenzoate moiety of 5,5"-dithiobis(2-nitrobenzoic acid).	Sulfhydryl Compounds	108-113	tryptophanyl-tRNA synthetase 1	Homo sapiens	7-35
7306-15	1976	Sodium sulfide gave an MCD spectrum which resembled that of the normal thiol Mb complex just after addition at pH 6.86.	Sulfhydryl Compounds	71-76	myoglobin	Homo sapiens	77-79
1268201-0	1976	Effect of bridging the two essential thiols of myosin on its spectral and actin-binding properties.	Sulfhydryl Compounds	37-43	myosin heavy chain 14	Homo sapiens	47-53
1268201-1	1976	The circular dichroic and fluorescent spectral properties of the myosin head (subfragment I (SFI)) modified by covalently bridging the two essential thiol groups have been examined.	Sulfhydryl Compounds	149-154	myosin heavy chain 14	Homo sapiens	65-71
1268201-6	1976	These results suggest that the local conformational state of the polypeptide chain formed on bridging the two thiol groups exhibits certain similarities with the state produced following binding of MgATP to native myosin.	Sulfhydryl Compounds	110-115	myosin heavy chain 14	Homo sapiens	214-220
5133-0	1976	Isolation, characterization and partial sequence of cyanogen bromide fragments and thiol peptides from pig kidney D-amino-acid oxidase.	Sulfhydryl Compounds	83-88	D-amino acid oxidase	Sus scrofa	114-134
931986-6	1976	One thiol group reacts rapidly unless L-tryptophan, ATP, and Mg2+ are present together.	Sulfhydryl Compounds	4-9	mucin 7, secreted	Homo sapiens	61-64
57822-7	1976	The results obtained in this study indicate that bleomycin inhibits DNA polymerases alpha and beta by a thiol reagent-dependent interaction with the template.	Sulfhydryl Compounds	104-109	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	68-89
775317-1	1976	Treatment of elongation factor G (EF-G) with the thiol reagent N-ethylmaleimide only partially inhibits (10 to 70%) the activity of the factor in (a) guanosine nucleotide-EF-G-ribosome complex formation, (b) uncoupled ribosome-dependent GTP hydrolysis, and (c) polypeptide synthesis.	Sulfhydryl Compounds	49-54	G elongation factor mitochondrial 1	Homo sapiens	34-38
775317-1	1976	Treatment of elongation factor G (EF-G) with the thiol reagent N-ethylmaleimide only partially inhibits (10 to 70%) the activity of the factor in (a) guanosine nucleotide-EF-G-ribosome complex formation, (b) uncoupled ribosome-dependent GTP hydrolysis, and (c) polypeptide synthesis.	Sulfhydryl Compounds	49-54	G elongation factor mitochondrial 1	Homo sapiens	171-175
1061133-0	1976	Reciprocal reactivities of specific thiols when actin binds to myosin.	Sulfhydryl Compounds	36-42	actin	Oryctolagus cuniculus	48-53
1272253-9	1976	Second, the transport system itself, whether in the basal state or after activation by insulin, lectins, or oxidants, is resistant to sulfhydryl reagents such as N-ethylmaleimide, while the increase in transport activity due to these agents is exquisitely sensitive to sulfhydryl blockage.	Sulfhydryl Compounds	134-144	insulin	Homo sapiens	87-94
1253791-3	1976	A small amount of free thiol groups, totally about 0.4 groups per mole of protein, were shown to be present on both the heavy and light chains of the IgA dimer, but not on its J-chain, while no such groups could be demonstrated on free secretory component.	Sulfhydryl Compounds	23-28	CD79a molecule	Homo sapiens	150-153
985813-1	1976	About 100 S-fatty acyl thiol compounds designed as substrates for pancreatic lipase [EC 3.1.1.3] were synthesized and tested for susceptibility to hydrolysis by hog pancreatic lipase and hog hepatic carboxylic esterase [EC 3.1.1.1] using 5,5"-dithiobis(2-nitrobenzoic acid) as a chromogenic reagent to determine the hydrolytic rates of their S-acyl bonds.	Sulfhydryl Compounds	23-28	pancreatic lipase	Homo sapiens	66-83
170996-1	1975	The glucocorticoid receptor protein present in the high-speed supernant fraction of rat thymus tissue is extremely unstable, having a half-life of about 2 h at 4 degrees C. It was found that the decline in steroid-binding capacity could be slowed, though not arrested completely, by the addition of sulphydryl-protecting agents such as 2-mercaptoethanol or dithiothreitol, and by EDTA.	Sulfhydryl Compounds	299-309	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	4-27
191312-0	1976	Differential reactivity of the thiol groups of rabbit muscle creatine kinase.	Sulfhydryl Compounds	31-36	creatine kinase M-type	Oryctolagus cuniculus	54-76
73-0	1975	Radioactive labeling and location of specific thiol groups in myosin from fast, slow and cardiac muscles.	Sulfhydryl Compounds	46-51	myosin heavy chain 14	Homo sapiens	62-68
73-2	1975	Based on incorporation of radioactively labeled N-ethylmaleimide, the readily reactive thiol groups of isolated myosin (EC 3.6.1.3) from fast, slow and cardiac muscles could be classified into 3 types.	Sulfhydryl Compounds	87-92	myosin heavy chain 14	Homo sapiens	112-118
73-4	1975	Both thiol-1 and thiol-2 groups which are essential for functioning of the K+-stimulated ATPase, are located in the heavy chains in all 3 myosin types.	Sulfhydryl Compounds	5-10	myosin heavy chain 14	Homo sapiens	138-144
73-4	1975	Both thiol-1 and thiol-2 groups which are essential for functioning of the K+-stimulated ATPase, are located in the heavy chains in all 3 myosin types.	Sulfhydryl Compounds	17-22	myosin heavy chain 14	Homo sapiens	138-144
127613-2	1975	A purine disulfide analog of ATP, 6,6"-dithiobis(inosinyl imidodiphosphate), forms mixed disulfide bonds between the 6 thiol group on the purine ring and certain key cysteines on myosin, heavy meromyosin, and subfragment one.	Sulfhydryl Compounds	119-124	myosin heavy chain 14	Homo sapiens	179-185
9766-12	1976	Cathepsin H is a thiol-enzyme with a molecular weight of 28000 and a pI of 7,1.	Sulfhydryl Compounds	17-22	cathepsin H	Rattus norvegicus	0-11
8154-1	1976	Enzymic studies performed with chemically modified yeast hexokinase (ATP : D-hexose-6-phosphotransferase) confirm previous results indicating that the sulfhydryl, imidazol and most of the reactive amino groups do not seem to be directly implicated in the enzyme active site.	Sulfhydryl Compounds	151-161	hexokinase	Saccharomyces cerevisiae S288C	57-67
137809-5	1976	The sulphydryl groups of actomyosin reacting with 5,5"-dithiobis-(2-nitrobenzoic acid) were blocked by concentrations of 5HT which inhibited the Mg2+-activated ATPase.	Sulfhydryl Compounds	4-14	dynein axonemal heavy chain 8	Homo sapiens	160-166
56186-5	1975	Removal, using mercaptoethanol, of the thiol blocking groups from the DTNB-treated CEA resulted in a 55% recovery of antigenic activity.	Sulfhydryl Compounds	39-44	CEA cell adhesion molecule 3	Homo sapiens	83-86
128454-3	1975	Sulfhydryl titrations of the heavy chain showed that the partial reduction involved primarily the cleavage of the sole interchain disulfide bridge of plasmin.	Sulfhydryl Compounds	0-10	plasminogen	Homo sapiens	150-157
240419-0	1975	The thiol group of bovine serum albumin.	Sulfhydryl Compounds	4-9	albumin	Homo sapiens	26-39
809280-0	1975	Purification of alpha1-antitrypsin from plasma through thiol-disulfide interchange.	Sulfhydryl Compounds	55-60	serpin family A member 1	Canis lupus familiaris	16-34
240419-2	1975	The reaction between 2,2"-dipyridyl disulphide and the thiol group in bovine serum albumin has been studied at pH 1.1-7.9.	Sulfhydryl Compounds	55-60	albumin	Homo sapiens	77-90
1181010-1	1975	The inhibition by some thiol reagents of partly purified mitochondrial monoamine oxidase (MAO) (EC 1.4.3.4) from rat liver was studied, and the molar content of sulfhydryl groups in the enzyme determined.	Sulfhydryl Compounds	23-28	monoamine oxidase A	Rattus norvegicus	71-88
52360-4	1975	The results suggest that all hexokinase type I isoenzymes may have a common antigenic site irrespective of their sources, though their responses to a thiol inhibitor are different.	Sulfhydryl Compounds	150-155	hexokinase 1	Rattus norvegicus	29-46
1181010-1	1975	The inhibition by some thiol reagents of partly purified mitochondrial monoamine oxidase (MAO) (EC 1.4.3.4) from rat liver was studied, and the molar content of sulfhydryl groups in the enzyme determined.	Sulfhydryl Compounds	23-28	monoamine oxidase A	Rattus norvegicus	90-93
1181010-3	1975	Concentrations of the respective inhibitors causing 50% inhibition after 15 min of preincubation with the enzyme at pH 7.0 and 37 degrees C are 5.80 times 10(-4) M and 4.35 times 10(-5) M. The thiol compounds cysteine, dithiothreitol, and 2-mercaptoethanol did not inhibit MAO.	Sulfhydryl Compounds	193-198	monoamine oxidase A	Rattus norvegicus	273-276
127876-5	1975	The earliest sign of the deteriorating structure of the contractile proteins in lasting mitral heart disease is the growing content of thiol compounds of myosin.	Sulfhydryl Compounds	135-140	myosin heavy chain 14	Homo sapiens	154-160
132431-0	1975	Thiols of myosin.	Sulfhydryl Compounds	0-6	myosin heavy chain 14	Homo sapiens	10-16
1095053-0	1975	Essential thiols of yeast hexokinase: alkylation by a substrate-like reagent.	Sulfhydryl Compounds	10-16	hexokinase	Saccharomyces cerevisiae S288C	26-36
1178903-3	1975	Evidence is also presented to show that this binding of PGAs to the "acceptor" of the rabbit kidney is related to an interaction with a thiol group of 15-hydroxy prostaglandin dehydrogenase, the enzyme chiefly involved in the metabolism of prostaglandins.	Sulfhydryl Compounds	136-141	carbonyl reductase [NADPH] 1	Oryctolagus cuniculus	151-189
1175606-6	1975	Cholesterol 7alpha-hydroxylase activity is enhanced in vitro by thiol-containing substances like mercaptoethanol, dithiothreitol, or cysteamine.	Sulfhydryl Compounds	64-69	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	0-30
1095053-5	1975	All the alkylation of hexokinase B was shown to occur at two thiol groups per subunit, associated stoichiometrically with inactivation.	Sulfhydryl Compounds	61-66	hexokinase	Saccharomyces cerevisiae S288C	22-32
237532-0	1975	Essential and nonessential thiols of yeast hexokinase.	Sulfhydryl Compounds	27-33	hexokinase	Saccharomyces cerevisiae S288C	43-53
1170876-2	1975	The degradation of 125I-labeled insulin by enzyme purified from beef pancreas was studied with various thiol-containing compounds as cosubstrates.	Sulfhydryl Compounds	103-108	insulin	Homo sapiens	32-39
167802-4	1975	Spin count studies show an average of approximately 0.5 labeled sulfhydryl/tropomyosin molecule and only approximately 0.15 labeled amino group/molecule.	Sulfhydryl Compounds	64-74	spindlin 1	Homo sapiens	0-4
1157835-3	1975	Efficiency of colony formation observed after 2 days of culture was increased as much as 5-fold (to an average of 325 colonies/10-5 nucleated marrow cells) by the addition of thiol (either beta-mercaptoethanol or alphal-thioglycerol) at a final concentration of 10 minus 4 M. Optimum efficiency required 0.5 erythropoietin units/ml and was influenced by the purity of the preparation.	Sulfhydryl Compounds	175-180	erythropoietin	Mus musculus	308-322
1137567-5	1975	MDH isoenzymes differ in their response to heat and thiol reagents.	Sulfhydryl Compounds	52-57	malic enzyme 1	Homo sapiens	0-3
164224-4	1975	Selective modification of the active site cysteine residue (149) and determinations of total sulphydryl content implicate this residue as the site of the immobile spin-label.	Sulfhydryl Compounds	93-103	spindlin 1	Homo sapiens	163-167
126941-2	1975	Changes in the mono- and divalentcation-stimulated ATPase activities of myosin progressively labeled with N-ethyl-[2,3-14C2]-maleimide were used to classify the readily reacting thiol groups into 3 types.	Sulfhydryl Compounds	178-183	myosin heavy chain 14	Homo sapiens	72-78
126941-3	1975	The results show that one thiol-1 and one thiol-2 group are associated with each of the 2 active sites of myosin.	Sulfhydryl Compounds	26-31	myosin heavy chain 14	Homo sapiens	106-112
126941-3	1975	The results show that one thiol-1 and one thiol-2 group are associated with each of the 2 active sites of myosin.	Sulfhydryl Compounds	42-47	myosin heavy chain 14	Homo sapiens	106-112
126941-8	1975	In the conformation of the long-lived myosin-product intermediate occuring during hydrolysis of Mg-ATP at 25 degrees C, 4 thiol groups of the third class react as well as or even more readily than those of the first and second classes.	Sulfhydryl Compounds	122-127	myosin heavy chain 14	Homo sapiens	38-44
234501-12	1975	The trypsin and elastase binding and inhibiting capacity of alpha1-AT remains after cleavage of the internal -S-S-bridge of alpha1-AT through interchange with a light chain thiol for which reason an intact internal -S-S-bridge of alpha1-AT is not necessary for inhibition and linkdage of the enzymes.	Sulfhydryl Compounds	173-178	serpin family A member 1	Homo sapiens	60-69
57940-4	1975	The alpha2-macroglobulin on a molar basis, is superior as an inhibitor to the metal-binding agents and thiols.	Sulfhydryl Compounds	103-109	alpha-2-macroglobulin	Homo sapiens	4-24
1157835-4	1975	When cultures contained thiol and high doses (3 units/ml) of purified erythropoietin, a second population of erythroid colonies became apparent after 5 days of culture, and increased in size to macroscopic dimensions by the tenth day, when they contained as many as 10-4 cells.	Sulfhydryl Compounds	24-29	erythropoietin	Mus musculus	70-84
4528467-0	1974	Chemical modulation of cell surfaces by sulfhydryl compounds: effect on C3b receptors.	Sulfhydryl Compounds	40-60	endogenous retrovirus group K member 3	Homo sapiens	72-75
1054516-2	1975	Primary explants of P388, EL-4, and L1210 murine leukemia cells and of normal mouse bone marrow are shown to require sulfhydryl compounds for proliferation in vitro.	Sulfhydryl Compounds	117-137	epilepsy 4	Mus musculus	26-30
4609485-0	1974	Isolation, characterization and partial sequencing of cystine and thiol peptides of pig heart lipoamide dehydrogenase.	Sulfhydryl Compounds	66-71	dihydrolipoamide dehydrogenase	Sus scrofa	94-117
4421676-0	1974	Thiol groups of liver alcohol dehydrogenase.	Sulfhydryl Compounds	0-5	aldo-keto reductase family 1 member A1	Homo sapiens	22-43
1153192-6	1975	CS2 is formed in high yield (a few percent) in mixtures containing 40-50% of H2S, while the maximum concentration of thiols (i.e., CH3SH and C2H5SH) is reached with lower percentages of H2S.	Sulfhydryl Compounds	117-123	chorionic somatomammotropin hormone 2	Homo sapiens	0-3
4463957-10	1974	The 3-carboxy-4-nitrothio-phenolate released was consistent with the reaction of 2 thiol groups/molecule of Factor XIII(a).	Sulfhydryl Compounds	83-88	coagulation factor XIII A chain	Homo sapiens	108-122
4463957-12	1974	This indicated that the a" chains of Factor XIII(a) were responsible for the thiol reactivity of the enzyme.	Sulfhydryl Compounds	77-82	coagulation factor XIII A chain	Homo sapiens	37-51
4763327-0	1973	The identity of the insulin degrading thiol-protein disulfide oxidoreductase (glutathione-insulin transhydrogenase) with the sulfhydryl-disulfide interchange enzyme.	Sulfhydryl Compounds	38-43	thioredoxin reductase 1	Homo sapiens	62-76
4842301-2	1974	New thiol-oxidizing agents: DIP, DIP+1, DIP+2.	Sulfhydryl Compounds	4-9	disco interacting protein 2 homolog A	Homo sapiens	40-45
4372632-1	1974	The ATPase (EC 3.6.1.3) of sarcoplasmic reticulum vesicles was reacted to various extents with thiol-directed spin labels.	Sulfhydryl Compounds	95-100	dynein axonemal heavy chain 8	Homo sapiens	4-10
4372632-1	1974	The ATPase (EC 3.6.1.3) of sarcoplasmic reticulum vesicles was reacted to various extents with thiol-directed spin labels.	Sulfhydryl Compounds	95-100	spindlin 1	Homo sapiens	110-114
4372632-7	1974	The data were reconciled by a simple rotary model, envisioning that an enzymatic state corresponds to an average angular position of the ATPase and thereby determines the proportion of labeled thiols exposed to external and internal ascorbate concentrations.	Sulfhydryl Compounds	193-199	dynein axonemal heavy chain 8	Homo sapiens	137-143
4831231-0	1974	4,4"-Bis-dimethylaminodiphenylcarbinol modification of active center sulfhydryl residues in malate dehydrogenase.	Sulfhydryl Compounds	69-79	malic enzyme 1	Homo sapiens	92-112
4463972-0	1974	Difference in kinetic properties between hexokinase type I isoenzymes from various rat tissues with reference to the effect of a thiol inhibitor.	Sulfhydryl Compounds	129-134	hexokinase 1	Rattus norvegicus	41-58
4763327-0	1973	The identity of the insulin degrading thiol-protein disulfide oxidoreductase (glutathione-insulin transhydrogenase) with the sulfhydryl-disulfide interchange enzyme.	Sulfhydryl Compounds	38-43	prolyl 4-hydroxylase subunit beta	Homo sapiens	78-114
4784454-0	1973	Chemical modification of sulfhydryl residues of rabbit triosephosphate isomerase.	Sulfhydryl Compounds	25-35	triosephosphate isomerase	Oryctolagus cuniculus	55-80
4356293-2	1973	Protein thiols as co-substrates for glutathione-insulin transhydrogenase.	Sulfhydryl Compounds	8-14	prolyl 4-hydroxylase subunit beta	Homo sapiens	36-72
4361111-0	1973	Electron spin resonance of myosin spin labeled at the S1 thiol groups during hydrolysis of adenosine triphosphate.	Sulfhydryl Compounds	57-62	myosin heavy chain 14	Homo sapiens	27-33
4736435-2	1973	Effect of thiol and disulfide compounds on activities of thioldisulfide transhydrogenase, glutathione reductase and glucose-6-phosphate dehydrogenase].	Sulfhydryl Compounds	10-15	glucose-6-phosphate dehydrogenase	Homo sapiens	116-149
4740680-0	1973	[The anti-hepatotoxic effect of aliphatic and heterocyclic mercapto compounds in CCl4-induced liver damage in the rat.	Sulfhydryl Compounds	59-77	C-C motif chemokine ligand 4	Rattus norvegicus	81-85
4740681-0	1973	[The anti-hepatotoxic effect of aliphatic and heterocyclic mercapto compounds in CCl4-induced liver damage in the rat.	Sulfhydryl Compounds	59-77	C-C motif chemokine ligand 4	Rattus norvegicus	81-85
4740682-0	1973	[The effect of aliphatic and heterocyclic mercapto compounds on lipid peroxidation in CCl4-induced liver damage in the rat].	Sulfhydryl Compounds	42-60	C-C motif chemokine ligand 4	Rattus norvegicus	86-90
4676313-0	1972	A study of the subunit structure and the thiol reactivity of bovine liver uridine diphosphate glucose dehydrogenase.	Sulfhydryl Compounds	41-46	glucose dehydrogenase	Bos taurus	94-115
4263471-0	1972	Nuclear magnetic resonance studies of heavy metal ion-sulfhydryl interactions in myosin.	Sulfhydryl Compounds	54-64	myosin heavy chain 14	Homo sapiens	81-87
4566096-11	1972	It is suggested that insulin release may be regulated by relatively superficial thiol groups in the beta-cell plasma membrane.	Sulfhydryl Compounds	80-85	insulin	Homo sapiens	21-28
4344134-0	1972	The effects of nucleotides and Mg 2+  on the electron spin resonance spectra of myosin spin labeled at the S 2  thiol groups.	Sulfhydryl Compounds	112-117	myosin heavy chain 14	Homo sapiens	80-86
4097521-0	1970	Phosphorylation coupled to oxidation of thiol groups (GSH) by cytochrome c with disulfide (GSSG) as an essential catalyst.	Sulfhydryl Compounds	40-45	cytochrome c, somatic	Homo sapiens	62-74
5076228-1	1972	In the presence of mercaptans, IgM(p) partially dissociated into Fc(mu)-like and Fab(mu) fragments.	Sulfhydryl Compounds	19-29	FA complementation group B	Homo sapiens	81-84
4622270-0	1972	Effect of thiol compounds on melanin formation by tyrosinase.	Sulfhydryl Compounds	10-15	tyrosinase	Homo sapiens	50-60
4333936-5	1971	The thiol groups of the light components of myosin are essential to preserve the ATPase activity of the protein and are close to the pyrophosphate-binding sites.	Sulfhydryl Compounds	4-9	myosin heavy chain 14	Homo sapiens	44-50
5500320-0	1970	Mammalian ornithine decarboxylase: activation and alteration of physical behaviour by thiol compounds.	Sulfhydryl Compounds	86-91	ornithine decarboxylase 1	Homo sapiens	10-33
4333936-0	1971	The location of the thiol groups of myosin that are protected by pyrophosphate against reaction with 2,4-dinitrophenyl  -hydroxyethyl disulphide.	Sulfhydryl Compounds	20-25	myosin heavy chain 14	Homo sapiens	36-42
4333936-2	1971	The residual Ca(2+)-stimulated adenosine triphosphatase (ATPase) activity of the modified myosin was different depending on the presence or absence of PP(i) during modification and the number of 2,4-dinitrophenyl beta-hydroxyethyl disulphide-modified thiol groups.	Sulfhydryl Compounds	251-256	myosin heavy chain 14	Homo sapiens	90-96
4331039-0	1971	The conformation of myosin during the steady state of ATP hydrolysis: studies with myosin spin labeled at the S 1  thiol groups.	Sulfhydryl Compounds	115-120	myosin heavy chain 14	Homo sapiens	20-26
5551216-0	1971	Studies of the effect of sulphydryl and other inhibitors on reticulocyte uptake of doubly-labelled transferrin.	Sulfhydryl Compounds	25-35	transferrin	Homo sapiens	99-110
5102321-0	1971	Degradation of IgG3 monoclonal proteins during storage and in the presence of a thiol (DL-penicillamine).	Sulfhydryl Compounds	80-85	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	15-19
4321371-0	1970	Effect of nucleotides and pyrophosphate on spin labels bound to S1 thiol groups of myosin.	Sulfhydryl Compounds	67-72	myosin heavy chain 14	Homo sapiens	83-89
4319825-0	1970	Phosphorylation coupled to oxidation of thiol groups (GSH) by cytochrome c with disulfide (GSSG) as an essential catalyst.	Sulfhydryl Compounds	40-45	cytochrome c, somatic	Homo sapiens	62-74
5474790-0	1970	Phosphorylation coupled to oxidation of thiol groups (GSH) by cytochrome c with disulfide (GSSG) as an essential catalyst.	Sulfhydryl Compounds	40-45	cytochrome c, somatic	Homo sapiens	62-74
5474791-0	1970	Phosphorylation coupled to oxidation of thiol groups (GSH) by cytochrome c with disulfide (GSSG) as an essential catalyst.	Sulfhydryl Compounds	40-45	cytochrome c, somatic	Homo sapiens	62-74
5435994-0	1970	The effect of age and protein deprivation on the sulfhydryl content of serum albumin.	Sulfhydryl Compounds	49-59	albumin	Homo sapiens	71-84
5515524-0	1970	[Participation of sulfhydryl compounds in formation of methemoglobin].	Sulfhydryl Compounds	18-38	hemoglobin subunit gamma 2	Homo sapiens	55-68
5271756-2	1969	In the case of the serine protease subtilisin, the catalytic serine residue can be specifically replaced by a cysteine residue and this modified enzyme is called thiol-subtilisin.	Sulfhydryl Compounds	162-167	coagulation factor II, thrombin	Homo sapiens	19-34
5360692-0	1969	Active-site thiol groups of yeast hexokinase.	Sulfhydryl Compounds	12-17	hexokinase	Saccharomyces cerevisiae S288C	34-44
4980717-6	1969	This reaction probably involves the thiol group of bovine serum albumin; it does not occur with bovine serum albumin which has been treated with p-chloromercuribenzoate, iodoacetamide or Ellman"s reagent.	Sulfhydryl Compounds	36-41	albumin	Homo sapiens	58-71
4309596-15	1969	When myosin is modified with a thiol reagent (p-mercuribenzoate) at a certain ratio to myosin, the inhibition by Mg(2+) becomes unobservable.	Sulfhydryl Compounds	31-36	myosin heavy chain 14	Homo sapiens	5-11
4309596-15	1969	When myosin is modified with a thiol reagent (p-mercuribenzoate) at a certain ratio to myosin, the inhibition by Mg(2+) becomes unobservable.	Sulfhydryl Compounds	31-36	myosin heavy chain 14	Homo sapiens	87-93
5365339-0	1969	Effect of sulphydryl inhibition on the uptake of transferrin-bound iron by reticulocytes.	Sulfhydryl Compounds	10-20	transferrin	Homo sapiens	49-60
5685849-0	1968	Nuclear protein thiol in cultured mammalian cells.	Sulfhydryl Compounds	16-21	negative elongation factor complex member E	Homo sapiens	0-15
5782031-0	1969	Inhibition of catalase and lactate dehydrogenase by radiation-protective thiols and thiol derivatives.	Sulfhydryl Compounds	73-79	catalase	Homo sapiens	14-22
5782031-0	1969	Inhibition of catalase and lactate dehydrogenase by radiation-protective thiols and thiol derivatives.	Sulfhydryl Compounds	73-78	catalase	Homo sapiens	14-22
4883828-0	1968	Direct isolation of thiol-containing peptides from insulin using a water-insoluble organomercurial copolymer of ethylene and maleic acid.	Sulfhydryl Compounds	20-25	insulin	Homo sapiens	51-58
5703740-0	1968	[The effect of thiol reagents on the activity of yeast hexokinase].	Sulfhydryl Compounds	15-20	hexokinase	Saccharomyces cerevisiae S288C	55-66
5660634-0	1968	Selective purification of the thiol peptides of myosin.	Sulfhydryl Compounds	30-35	myosin heavy chain 14	Homo sapiens	48-54
5665887-1	1968	The reactivity of the three disulphide bridges of insulin towards sodium sulphite was studied by amperometric titration of the liberated thiol groups.	Sulfhydryl Compounds	137-142	insulin	Homo sapiens	50-57
5660634-7	1968	The thiol peptides in a peptic digest of cystine-exchanged myosin were purified in this way, and their amino acid sequences were determined.	Sulfhydryl Compounds	4-9	myosin heavy chain 14	Homo sapiens	59-65
5660634-9	1968	The conclusion that myosin contains at least 16, and probably between 20 and 22, unique thiol sequences indicates that the molecule consists of two chemically equivalent components.	Sulfhydryl Compounds	88-93	myosin heavy chain 14	Homo sapiens	20-26
5637605-0	1968	Reaction of lysozyme with dithiothreitol and other mercaptans.	Sulfhydryl Compounds	51-61	lysozyme	Homo sapiens	12-20
5645457-0	1968	[Detection of an effect of thiol group blockade on heme in a single-chain hemoprotein: tunny myoglobin].	Sulfhydryl Compounds	27-32	myoglobin	Homo sapiens	93-102
5641885-0	1968	Amino acid sequences aroung the thiol groups of myokinase.	Sulfhydryl Compounds	32-37	adenylate kinase 1	Homo sapiens	48-57
6048771-3	1967	Haems are unstable under aerobic conditions in the presence of thiols, which are used to activate the ferrochelatase enzyme; catalase inhibits this degradation of haem.	Sulfhydryl Compounds	63-69	ferrochelatase	Homo sapiens	102-116
4380024-0	1966	The effect of thiols and ganglioside on the alterations in water, sodium and potassium distribution produced in brain slices by vasopressin and protamine.	Sulfhydryl Compounds	14-20	arginine vasopressin	Homo sapiens	128-139
6034675-0	1967	Inhibition of dopamine beta-hydroxylase by sulfhydryl compounds and the nature of the natural inhibitors.	Sulfhydryl Compounds	43-63	dopamine beta-hydroxylase	Homo sapiens	14-39
6027244-0	1967	The thiol groups of fumarase.	Sulfhydryl Compounds	4-9	fumarate hydratase	Homo sapiens	20-28
5925864-0	1966	The reversible conversion of lipoyl dehydrogenase to an artifactual enzyme by oxidation of sulfhydryl groups.	Sulfhydryl Compounds	91-101	dihydrolipoamide dehydrogenase	Homo sapiens	29-49
5971868-2	1966	The disulfide and sulfhydryl content of beef-liver catalase].	Sulfhydryl Compounds	18-28	catalase	Homo sapiens	51-60
4287347-0	1966	Influence of substrate-induced enzymic inactivation on the sulfhydryl content of glyceraldehyde-3-phosphate dehydrogenase.	Sulfhydryl Compounds	59-69	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	81-121
5941349-7	1966	Treatment of the supernatant fraction with N-ethylmaleimide resulted in release of large amounts of ribonuclease activity, indicating the presence of a ribonuclease inhibitor having reactive thiol groups.	Sulfhydryl Compounds	191-196	ribonuclease/angiogenin inhibitor	Rattus norvegicus	152-174
5866720-0	1965	Potentiation of some bradykinin effects by thiol compounds.	Sulfhydryl Compounds	43-48	kininogen 1	Homo sapiens	21-31
5938660-10	1966	Galactokinase phosphorylates 2-deoxygalactose and galactosamine in addition to galactose, has a pH optimum of 7.8, a Q(10) of 2, and is stimulated by cysteine and other thiols.	Sulfhydryl Compounds	169-175	galactokinase	Saccharomyces cerevisiae S288C	0-13
5848028-0	1965	An improved assay of erythrocyte and leukocyte galactose-1-phosphate uridyl transferase: stabilization of the enzyme by a thiol protective reagent.	Sulfhydryl Compounds	122-127	galactose-1-phosphate uridylyltransferase	Homo sapiens	47-87
5863319-0	1965	A zinc-binding thiol group in the active center of bovine carboxypeptidase B.	Sulfhydryl Compounds	15-20	carboxypeptidase B1	Bos taurus	58-76
5859511-0	1965	A critical study of amperometric titration methods for sulfhydryl determination in native and denatured bovine serum albumin.	Sulfhydryl Compounds	55-65	albumin	Homo sapiens	111-124
14209332-0	1964	CHROMATOGRAPHIC PURIFICATION OF THE THIOL ENZYME CATHEPSIN C.	Sulfhydryl Compounds	36-41	cathepsin C	Homo sapiens	49-60
14343136-0	1965	THE ACTION OF THIOL REAGENTS ON THE ADENOSINE-TRIPHOSPHATASE ACTIVITIES OF HEAVY MEROMYOSIN AND L-MYOSIN.	Sulfhydryl Compounds	14-19	myosin heavy chain 14	Homo sapiens	85-91
14343136-4	1965	Stimulation of the Ca(2+)-activated adenosine triphosphatase of both heavy meromyosin and myosin by thiol reagents is markedly affected by ionic strength, the effects being greater with the former than with the latter.	Sulfhydryl Compounds	100-105	myosin heavy chain 14	Homo sapiens	79-85
14343136-7	1965	The precise behaviour of the thiol reagents at low ionic strength is slightly modified by the age of the heavy meromyosin and myosin preparations.	Sulfhydryl Compounds	29-34	myosin heavy chain 14	Homo sapiens	115-121
14343136-11	1965	The adenosine triphosphatases of heavy meromyosin and myosin activated by potassium chloride in the absence of bivalent activators are inhibited by thiol reagents over the range of ionic strength at which stimulation occurs in the presence of calcium chloride as activator.	Sulfhydryl Compounds	148-153	myosin heavy chain 14	Homo sapiens	43-49
14240991-0	1964	EFFECTS OF SOME SULFHYDRYL COMPOUNDS ON THE MAGNESIUM-ENHANCED ADENOSINETRIPHOSPHATASE ACTIVITY OF MYOSIN B.	Sulfhydryl Compounds	16-36	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	63-86
4975312-2	1969	The amino acid sequences around the thiol groups of glyceraldehyde 3-phosphate dehydrogenase from badger and monkey skeletal muscle were compared with the sequences around the thiol groups in the enzyme isolated from other organisms.	Sulfhydryl Compounds	36-41	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	52-92
4975312-2	1969	The amino acid sequences around the thiol groups of glyceraldehyde 3-phosphate dehydrogenase from badger and monkey skeletal muscle were compared with the sequences around the thiol groups in the enzyme isolated from other organisms.	Sulfhydryl Compounds	176-181	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	52-92
14192907-0	1964	MODIFICATION OF L-MYOSIN BY DISULFIDE-SULFHYDRYL INTERCHANGE REACTION.	Sulfhydryl Compounds	38-48	myosin heavy chain 14	Homo sapiens	18-24
13714413-3	1961	The heat lability, substrate and coenzyme specificity, and sulfhydryl and phosphate dependence of the tissue component catalyzing this reaction indicate that glyceraldehyde-3-phosphate dehydrogenase activity is being demonstrated.	Sulfhydryl Compounds	59-69	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	158-198
13935833-0	1963	Effect of vasopressin and dehydration on protein-bound sulfhydryl and disulfide groups in renal cells.	Sulfhydryl Compounds	55-65	arginine vasopressin	Homo sapiens	10-21
13876609-0	1962	The disulfide-sulfhydryl interchange as a mechanism of insulin action.	Sulfhydryl Compounds	14-24	insulin	Homo sapiens	55-62
14042998-5	1963	On the basis of the results it was postulated that hormone-receptor interaction can be considered a two-step process: (a) The binding or attachment of hormone to receptor site through ionic, hydrogen, and hydrophobic bonds and (b) a disulfide interchange reaction between hormonal disulfide and receptor sulfhydryl.	Sulfhydryl Compounds	304-314	nuclear receptor subfamily 4 group A member 1	Homo sapiens	51-67
14450387-0	1962	[Effect of muscle activity on the relation of myosin thiol groups to adenosinetriphosphoric acid].	Sulfhydryl Compounds	53-58	myosin heavy chain 14	Homo sapiens	46-52
13084626-0	1953	Coenzyme binding and the thiol groups of glyceraldehyde-3-phosphate dehydrogenase.	Sulfhydryl Compounds	25-30	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	41-81
13839947-0	1960	Effect of sulphydryl group reagents on tryptophanase activity.	Sulfhydryl Compounds	10-20	tryptophan 2,3-dioxygenase	Homo sapiens	39-52
13143031-0	1954	Effect of vitamin B12 on liver and blood non-protein sulfhydryl compounds.	Sulfhydryl Compounds	53-73	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	18-21
33932368-0	2021	Disentangling chloroplast ATP synthase regulation by proton motive force and thiol modulation in Arabidopsis leaves.	Sulfhydryl Compounds	77-82	ATP synthase	Arabidopsis thaliana	26-38
13061586-0	1953	The effect of intravenous ACTH on the blood level of ascorbic acid and of sulfhydryl as determined by a modified amperometric technique.	Sulfhydryl Compounds	74-84	proopiomelanocortin	Homo sapiens	26-30
14955620-7	1952	By means of the amperometric silver titration of Kolthoff and Harris, it is shown that sulfhydryl groups are liberated in the bleaching of rhodopsin, two such groups for each retinene(1) molecule that appears.	Sulfhydryl Compounds	87-97	rhodopsin	Bos taurus	139-148
20285166-0	1947	The relationship of sulfhydryl and disulfide groups to the antigenic power of bovine serum albumin.	Sulfhydryl Compounds	20-30	albumin	Homo sapiens	85-98
13061470-0	1953	Effect of vitamin B12 on the levels of soluble sulfhydryl compounds in blood.	Sulfhydryl Compounds	47-67	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	18-21
33601276-10	2021	Moreover, Alb reacted with GSH/GSSG via thiol-disulfide exchange and reciprocally regulated the availability of -SH groups.	Sulfhydryl Compounds	40-45	albumin	Mus musculus	10-13
33905956-5	2021	Within 10 min of ascorbate addition, we detected increased oxidation of erythrocyte peroxiredoxin 2 (Prx2), a major thiol antioxidant protein and a sensitive marker of H2O2 production.	Sulfhydryl Compounds	116-121	peroxiredoxin 2	Homo sapiens	84-99
33905956-5	2021	Within 10 min of ascorbate addition, we detected increased oxidation of erythrocyte peroxiredoxin 2 (Prx2), a major thiol antioxidant protein and a sensitive marker of H2O2 production.	Sulfhydryl Compounds	116-121	peroxiredoxin 2	Homo sapiens	101-105
33965839-0	2021	Spectroscopic and biochemical characterization of metallo-beta-lactamase IMP-1 with dicarboxylic, sulfonyl, and thiol inhibitors.	Sulfhydryl Compounds	112-117	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	73-78
33961403-4	2021	Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity.	Sulfhydryl Compounds	56-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	159-179
33961403-4	2021	Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity.	Sulfhydryl Compounds	56-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	181-185
33961403-4	2021	Interestingly, S-S-AuNCs displayed a unique response to thiol compounds and low pH values and were thus pioneered as a high-efficiency sensor for OPs based on acetylcholinesterase (AChE)-catalyzed hydrolysis of acetylthiocholine into thiocholine and CH3COOH and OP inhibition of AChE activity.	Sulfhydryl Compounds	56-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	279-283
34002274-5	2021	A low concentration of lysozyme was then added to occupy the high-affinity cavities of the polymer and sterically protect the thiol groups within them.	Sulfhydryl Compounds	126-131	lysozyme	Homo sapiens	23-31
33636492-2	2021	D-Pen molecules contain a thiol which can combine with Ag to form a non-fluorescent ground state complex, inducing the aggregation of DNA-AgNCs followed by the fluorescence quenching.	Sulfhydryl Compounds	26-31	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	2-5
33724816-3	2021	In particular, thiopeptolide/thio-depsipeptides were capable of pH-sensitive thiol-thioester exchange reactions to yield alpha,omega-dithiols, which react with maleimide-functionalized multi-arm polyethylene glycol to polymer networks.	Sulfhydryl Compounds	77-82	phenylalanine hydroxylase	Homo sapiens	64-66
33249721-4	2021	The reaction of hSR with either NO or nitroso donors is conformation-dependent and occurs only in the conformation stabilized by the allosteric effector ATP, in which the epsilon-amino group of Lys114 acts as a base towards the thiol group of Cys113.	Sulfhydryl Compounds	228-233	HSR	Homo sapiens	16-19
33249721-5	2021	In the closed conformation stabilized by glycine - an active-site ligand of hSR - the side chain of Lys114 moves away from that of Cys113, while the carboxyl side-chain group of Asp318 moves significantly closer, increasing the thiol pKa and preventing the reaction.	Sulfhydryl Compounds	228-233	HSR	Homo sapiens	76-79
33107103-4	2021	Different isoforms of HMGB1 present with distinctive physiological functions in ECM-fully-reduced HMGB1 (all thiol) acts as the initial damage signal to recruit circulating myeloid cells, disulfide HMGB1 behaves as a cytokine to activate macrophages and neutrophils, and both signals are turned off when HMGB1 is terminally oxidized into the final sulfonate form.	Sulfhydryl Compounds	109-114	high mobility group box 1	Homo sapiens	22-27
33107103-4	2021	Different isoforms of HMGB1 present with distinctive physiological functions in ECM-fully-reduced HMGB1 (all thiol) acts as the initial damage signal to recruit circulating myeloid cells, disulfide HMGB1 behaves as a cytokine to activate macrophages and neutrophils, and both signals are turned off when HMGB1 is terminally oxidized into the final sulfonate form.	Sulfhydryl Compounds	109-114	high mobility group box 1	Homo sapiens	98-103
33107103-4	2021	Different isoforms of HMGB1 present with distinctive physiological functions in ECM-fully-reduced HMGB1 (all thiol) acts as the initial damage signal to recruit circulating myeloid cells, disulfide HMGB1 behaves as a cytokine to activate macrophages and neutrophils, and both signals are turned off when HMGB1 is terminally oxidized into the final sulfonate form.	Sulfhydryl Compounds	109-114	high mobility group box 1	Homo sapiens	98-103
33107103-4	2021	Different isoforms of HMGB1 present with distinctive physiological functions in ECM-fully-reduced HMGB1 (all thiol) acts as the initial damage signal to recruit circulating myeloid cells, disulfide HMGB1 behaves as a cytokine to activate macrophages and neutrophils, and both signals are turned off when HMGB1 is terminally oxidized into the final sulfonate form.	Sulfhydryl Compounds	109-114	high mobility group box 1	Homo sapiens	98-103
33662873-5	2021	Early evidence in literature suggests that the thiol to disulfide balance of critical Cys residues of the COVID-19 spike protein and the ACE-2 receptor may influence the risk of infection and the severity of the disease, with a more oxidizing environment producing the worst prognosis.	Sulfhydryl Compounds	47-52	covid-19 spike protein	None	106-128
33662875-12	2021	Because zinc binding also protects PTP thiols form irreversible oxidation, there is a multi-faceted reciprocal interaction, illustrating that zinc- and redox-signaling are intricately linked on multiple levels.	Sulfhydryl Compounds	39-45	protein tyrosine phosphatase receptor type U	Homo sapiens	35-38
33627050-6	2021	To assess the plasma levels of malondialdehyde (MDA) and total thiol group (TTG), blood samples were garnered.Results: In the Abeta-injected rats, EPSP slope, and PS amplitude were significantly reduced after the induction of LTP.	Sulfhydryl Compounds	63-68	amyloid beta precursor protein	Rattus norvegicus	126-131
34047563-11	2021	More importantly, these results also suggest that Cd2+ can effectively be used for enhancing the fluorescence quantum yield of thiol-capped QDs such as GSH@ZAIS.	Sulfhydryl Compounds	127-132	CD2 molecule	Homo sapiens	50-53
33985344-6	2021	Four of the six H1 and H3 HA bonds are cleaved by the vascular thiol isomerases, thioredoxin and protein disulphide isomerase, in recombinant proteins, which correlated with surface exposure of the disulfides in crystal structures.	Sulfhydryl Compounds	63-68	thioredoxin	Homo sapiens	81-92
33724816-0	2021	Thiol-Thioester Exchange Reactions in Precursors Enable pH-Triggered Hydrogel Formation.	Sulfhydryl Compounds	0-5	phenylalanine hydroxylase	Homo sapiens	56-58
33960401-4	2021	Arsenic treatment caused high levels of oxidative stress in the slim1 mutants, and slim1 alleles were impaired in both thiol and sulfate accumulation.	Sulfhydryl Compounds	119-124	ETHYLENE-INSENSITIVE3-like 3	Arabidopsis thaliana	83-88
33955435-5	2021	The thiol functionalised CS (CS-SH)/HB-PEG hydrogel scaffolds were fabricated via thiol-ene reaction, which exhibits rapid gelation, excellent mechanical properties and prolonged degradation properties.	Sulfhydryl Compounds	4-9	citrate synthase	Rattus norvegicus	25-27
33955435-5	2021	The thiol functionalised CS (CS-SH)/HB-PEG hydrogel scaffolds were fabricated via thiol-ene reaction, which exhibits rapid gelation, excellent mechanical properties and prolonged degradation properties.	Sulfhydryl Compounds	4-9	citrate synthase	Rattus norvegicus	29-34
33955435-5	2021	The thiol functionalised CS (CS-SH)/HB-PEG hydrogel scaffolds were fabricated via thiol-ene reaction, which exhibits rapid gelation, excellent mechanical properties and prolonged degradation properties.	Sulfhydryl Compounds	82-87	citrate synthase	Rattus norvegicus	25-27
33955435-5	2021	The thiol functionalised CS (CS-SH)/HB-PEG hydrogel scaffolds were fabricated via thiol-ene reaction, which exhibits rapid gelation, excellent mechanical properties and prolonged degradation properties.	Sulfhydryl Compounds	82-87	citrate synthase	Rattus norvegicus	29-34
33885283-0	2021	Exploring the Versatility of the Covalent Thiol-Alkyne Reaction with Substituted Propargyl Warheads: A Deciding Role for the Cysteine Protease.	Sulfhydryl Compounds	42-47	cathepsin B	Homo sapiens	125-142
33885283-6	2021	Bottom-up mass spectrometric analysis of the covalent adduct with a deuterated propargyl ABP provides mechanistic understanding of the in situ thiol-alkyne reaction, identifying the alkyne rather than an allenic intermediate as the reactive species.	Sulfhydryl Compounds	143-148	amine oxidase copper containing 1	Homo sapiens	89-92
32311837-2	2021	The disulfide bond structure of the insulin was reduced to generate free sulfhydryl as a terminal group.	Sulfhydryl Compounds	73-83	insulin	Homo sapiens	36-43
33601276-1	2021	Albumin (Alb) is the most abundant plasma protein with multiple biological functions, including antioxidative property through its thiol activity.	Sulfhydryl Compounds	131-136	albumin	Mus musculus	0-3
33607500-4	2021	alpha1-microglobulin (A1M) is a ubiquitous protein with thiol-dependent antioxidant properties, protecting cells and matrix against oxidative damage due to its reductase activities and radical- and heme-binding properties.	Sulfhydryl Compounds	56-61	alpha-1-microglobulin/bikunin precursor	Homo sapiens	22-25
33966733-3	2021	The aim of this study was to investigate the lotho and thiol/disulfide levels in women with non-obese PCOS compared to healthy controls and also to investigate the relationship of serum Klotho and thiol/disulfide homeostasis with cardiometabolic risk factors.	Sulfhydryl Compounds	197-202	klotho	Homo sapiens	186-192
33966733-8	2021	Correlation analysis revealed that serum Klotho levels were negatively correlated with BMI, waist circumference, disulphide/total thiol, disulphide/native thiol, HOMA-IR and LAP-index.	Sulfhydryl Compounds	130-135	klotho	Homo sapiens	41-47
33966733-8	2021	Correlation analysis revealed that serum Klotho levels were negatively correlated with BMI, waist circumference, disulphide/total thiol, disulphide/native thiol, HOMA-IR and LAP-index.	Sulfhydryl Compounds	155-160	klotho	Homo sapiens	41-47
33607500-10	2021	The redox-active thiol group of A1M was unaffected by the binding to HS, and the cell protection and heme-binding abilities of A1M were slightly affected.	Sulfhydryl Compounds	17-22	PZP, alpha-2-macroglobulin like	Mus musculus	32-35
33913605-6	2021	The redox- and proton-neutral S- nitrosation process reported here represents the first functional model of ceruloplasmin in mediating S -nitrosation of external thiols, adding further implications for biological copper sites in the interconversion of NO   /RSNO.	Sulfhydryl Compounds	162-168	ceruloplasmin	Homo sapiens	108-121
33964761-1	2021	In the work, sulfhydryl functionalized montmorillonite nanosheets based hydrogel balls were firstly synthesized for Pb(II) adsorption, and then characterized by scanning electron microscope (SEM), fourier transform infrared spectroscopy (FTIR), surface area analyzer (BET), thermogravimetry (TG), and zeta potential.	Sulfhydryl Compounds	13-23	submaxillary gland androgen regulated protein 3B	Homo sapiens	116-122
33964761-1	2021	In the work, sulfhydryl functionalized montmorillonite nanosheets based hydrogel balls were firstly synthesized for Pb(II) adsorption, and then characterized by scanning electron microscope (SEM), fourier transform infrared spectroscopy (FTIR), surface area analyzer (BET), thermogravimetry (TG), and zeta potential.	Sulfhydryl Compounds	13-23	delta/notch like EGF repeat containing	Homo sapiens	268-271
33710874-8	2021	Thiol cleavability appraisal of the resultant C-S and C-N linked thio-bioconjugates demonstrated C-S functionalized linkers to be cleavable and C-N functionalized linkers to be noncleavable when incubated in an excess of glutathione.	Sulfhydryl Compounds	0-5	citrate synthase	Homo sapiens	46-49
33893288-3	2021	Here, we use thiol-reactive derivatives of the cosubstrate adenosine triphosphate (ATP) to covalently stabilize the transient FICD:BiP complex and determine its crystal structure.	Sulfhydryl Compounds	13-18	FIC domain protein adenylyltransferase	Homo sapiens	126-130
33893288-3	2021	Here, we use thiol-reactive derivatives of the cosubstrate adenosine triphosphate (ATP) to covalently stabilize the transient FICD:BiP complex and determine its crystal structure.	Sulfhydryl Compounds	13-18	heat shock protein family A (Hsp70) member 5	Homo sapiens	131-134
33710874-8	2021	Thiol cleavability appraisal of the resultant C-S and C-N linked thio-bioconjugates demonstrated C-S functionalized linkers to be cleavable and C-N functionalized linkers to be noncleavable when incubated in an excess of glutathione.	Sulfhydryl Compounds	0-5	citrate synthase	Homo sapiens	97-100
33844389-3	2021	Phenylacetamidomethyl (Phacm) protected homocysteine (HcP) was incorporated and its latent thiol group unmasked on purified proteins using pencillin G acylase (PGA).	Sulfhydryl Compounds	91-96	coproporphyrinogen oxidase	Homo sapiens	54-57
33675922-2	2021	Thiolated beta-CD was synthesized via replacement of all primary hydroxyl groups on beta-CD backbone by halogen followed by substitution with thiol groups.	Sulfhydryl Compounds	142-147	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	10-17
33675922-6	2021	Thiolated beta-CD displayed 5360 +- 412 micromol/g thiol groups.	Sulfhydryl Compounds	51-56	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	10-17
33607928-0	2021	Salmonella enterica BcfH is a trimeric thioredoxin-like bifunctional enzyme with both thiol oxidase and disulfide isomerase activities.	Sulfhydryl Compounds	86-91	thioredoxin	Bos taurus	39-50
33607928-5	2021	This contrasts with the eukaryotic disulfide forming machinery where the modular thioredoxin protein PDI mediates thiol oxidation and disulfide reshuffling.	Sulfhydryl Compounds	114-119	thioredoxin	Bos taurus	81-92
33916181-0	2021	An Activatable T1-Weighted MR Contrast Agent: A Noninvasive Tool for Tracking the Vicinal Thiol Motif of Thioredoxin in Live Cells.	Sulfhydryl Compounds	90-95	thioredoxin	Homo sapiens	105-116
33544162-0	2021	Novel voltammetric tumor necrosis factor-alpha (TNF-alpha) immunosensor based on gold nanoparticles involved in thiol-functionalized multi-walled carbon nanotubes and bimetallic Ni/Cu-MOFs.	Sulfhydryl Compounds	112-117	tumor necrosis factor	Homo sapiens	19-46
33544162-0	2021	Novel voltammetric tumor necrosis factor-alpha (TNF-alpha) immunosensor based on gold nanoparticles involved in thiol-functionalized multi-walled carbon nanotubes and bimetallic Ni/Cu-MOFs.	Sulfhydryl Compounds	112-117	tumor necrosis factor	Homo sapiens	48-57
33544162-4	2021	Herein, a novel, sensitive, and selective voltammetric TNF-alpha immunosensor was prepared by using gold nanoparticles involved in thiol-functionalized multi-walled carbon nanotubes (AuNPs/S-MWCNTs) as sensor platform and bimetallic Ni/Cu-MOFs as sensor amplification.	Sulfhydryl Compounds	131-136	tumor necrosis factor	Homo sapiens	55-64
33586042-7	2021	In the present study, the effects of LMM thiols on the inhibitory potential of ALB-Cys34SNO on human washed platelets were investigated.	Sulfhydryl Compounds	41-47	albumin	Homo sapiens	79-82
33586042-12	2021	It is assumed that the underlying mechanism involves S-transnitrosylation of SH groups of the platelet surface by LMM RSNO formed through the reaction of SNALB with the thiols: ALB-Cys34SNO + R-CysSH   ALB-Cys34SH + R-CysSNO.	Sulfhydryl Compounds	169-175	albumin	Homo sapiens	156-159
33586042-12	2021	It is assumed that the underlying mechanism involves S-transnitrosylation of SH groups of the platelet surface by LMM RSNO formed through the reaction of SNALB with the thiols: ALB-Cys34SNO + R-CysSH   ALB-Cys34SH + R-CysSNO.	Sulfhydryl Compounds	169-175	albumin	Homo sapiens	177-180
33916181-7	2021	The nontoxic nature of CA1, coupled with its relaxivity features, leads us to suggest that it constitutes a first-in-class MRI T1 contrast agent that allows for the facile and noninvasive monitoring of vicinal thiol protein motif expression in live cells.	Sulfhydryl Compounds	210-215	carbonic anhydrase 1	Homo sapiens	23-26
33839958-0	2021	Colorimetric detection of acetylcholinesterase and its inhibitor based on thiol-regulated oxidase-like activity of 2D palladium square nanoplates on reduced graphene oxide.	Sulfhydryl Compounds	74-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-46
33751892-3	2021	Reduced bovine serum albumin (BSA) molecules with six thiol groups were used to cross-link the shells of the micelles by reacting with the pendant pyridyl disulfide groups on the P(PEGMA-co-PDSMA) block.	Sulfhydryl Compounds	54-59	albumin	Mus musculus	15-28
33916181-1	2021	We have synthesized new magnetic resonance imaging (MRI) T1 contrast agents (CA1 and CA2) that permit the activatable recognition of the cellular vicinal thiol motifs of the protein thioredoxin.	Sulfhydryl Compounds	154-159	carbonic anhydrase 1	Homo sapiens	77-80
33916181-1	2021	We have synthesized new magnetic resonance imaging (MRI) T1 contrast agents (CA1 and CA2) that permit the activatable recognition of the cellular vicinal thiol motifs of the protein thioredoxin.	Sulfhydryl Compounds	154-159	carbonic anhydrase 2	Homo sapiens	85-88
33916181-1	2021	We have synthesized new magnetic resonance imaging (MRI) T1 contrast agents (CA1 and CA2) that permit the activatable recognition of the cellular vicinal thiol motifs of the protein thioredoxin.	Sulfhydryl Compounds	154-159	thioredoxin	Homo sapiens	182-193
33592758-7	2021	Thiol-bearing compounds such as thiocholine generated through the hydrolysis of acetylthiocholine by acetylcholinesterase (AChE) interacted with the surface of CdS QDs thus blocking the ECL.	Sulfhydryl Compounds	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-121
33592758-7	2021	Thiol-bearing compounds such as thiocholine generated through the hydrolysis of acetylthiocholine by acetylcholinesterase (AChE) interacted with the surface of CdS QDs thus blocking the ECL.	Sulfhydryl Compounds	0-5	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-127
33727589-3	2021	Gal-9 also binds to protein disulfide isomerase (PDI), maintains PDI on surface of T cells, and increases free thiols in the disulfide/thiol cycles.	Sulfhydryl Compounds	111-117	lectin, galactose binding, soluble 9	Mus musculus	0-5
33337576-1	2021	The difluoromethyl (CHF 2 ) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups.	Sulfhydryl Compounds	195-200	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	20-25
33727589-3	2021	Gal-9 also binds to protein disulfide isomerase (PDI), maintains PDI on surface of T cells, and increases free thiols in the disulfide/thiol cycles.	Sulfhydryl Compounds	111-116	lectin, galactose binding, soluble 9	Mus musculus	0-5
33515755-0	2021	Sulfenic acid in human serum albumin: reaction with thiols, oxidation and spontaneous decay.	Sulfhydryl Compounds	52-58	albumin	Homo sapiens	23-36
33656867-2	2021	DMSe has been recently revealed as a precursor of secondary organic aerosol (SOA), and its resultant SOA possesses strong oxidizing capability toward thiol groups that can perturb several major biological pathways in human airway epithelial cells and is linked to genotoxicity, DNA damage, and p53-mediated stress responses.	Sulfhydryl Compounds	150-155	tumor protein p53	Homo sapiens	294-297
33555180-3	2021	This work examines thiolation of BMP-2 for chemical attachment to a poly(ethylene glycol) hydrogel using thiol-norbornene click chemistry.	Sulfhydryl Compounds	19-24	bone morphogenetic protein 2	Mus musculus	33-38
33476933-3	2021	Multiple p97 inhibitors identified from previous high-throughput screening studies are thiol-reactive compounds targeting Cys522 in the D2 ATP-binding domain.	Sulfhydryl Compounds	87-92	valosin containing protein	Homo sapiens	9-12
33649977-9	2021	In addition, vit D elevated thiol content, SOD and CAT activities, and BDNF levels, while reduced nitrite and MDA concentration.	Sulfhydryl Compounds	28-33	vitrin	Rattus norvegicus	13-16
33875079-3	2021	METHODS: ScFvHER2 fragment was coupled with DM1 nanoparticles (NPs) via covalent thiol-maleimide linkages.	Sulfhydryl Compounds	81-86	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-17
33662397-6	2021	The structure together with DFT computational modeling demonstrate that 3HPA (and 3MPA) associate with iron as chelate complexes with the substrate-carboxylate group forming an additional interaction with Arg168 and the thiol bound at the same position as in CDO.	Sulfhydryl Compounds	220-225	cell adhesion associated, oncogene regulated	Homo sapiens	259-262
33649426-8	2021	Our results confirm, for the first time, that METTL7B, a gene implicated in multiple disease states including rheumatoid arthritis and breast cancer, encodes a protein that methylates small molecule alkyl thiols.	Sulfhydryl Compounds	205-211	methyltransferase like 7B	Homo sapiens	46-53
32979223-9	2021	These findings led us to propose that ROS levels modulate RAGE and/or TLR4-mediated inflammatory allodynia by regulating the concentrations of disulfide HMGB1 or all-thiol HMGB1.	Sulfhydryl Compounds	166-171	advanced glycosylation end product-specific receptor	Mus musculus	58-62
32979223-8	2021	Precisely, lower ROS levels contributed to the inflammatory pain response via the all-thiol HMGB1/RAGE signaling pathway during the chronic state.	Sulfhydryl Compounds	86-91	high mobility group box 1	Mus musculus	92-97
33649426-2	2021	Here we demonstrate with a range of experimental approaches using cell lines, in vitro systems, and recombinantly expressed enzyme, that human methyltransferase-like protein 7B (METTL7B) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to hydrogen sulfide (H2S) and other exogenous thiol small molecules.	Sulfhydryl Compounds	312-317	methyltransferase like 7B	Homo sapiens	143-176
33649426-2	2021	Here we demonstrate with a range of experimental approaches using cell lines, in vitro systems, and recombinantly expressed enzyme, that human methyltransferase-like protein 7B (METTL7B) catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to hydrogen sulfide (H2S) and other exogenous thiol small molecules.	Sulfhydryl Compounds	312-317	methyltransferase like 7B	Homo sapiens	178-185
33649426-4	2021	Furthermore, recombinantly expressed and purified wild-type METTL7B methylates several thiol compounds, including H2S, 7alpha-thiospironolactone, L-penicillamine, and captopril, in a time- and concentration-dependent manner.	Sulfhydryl Compounds	87-92	methyltransferase like 7B	Homo sapiens	60-67
32979223-8	2021	Precisely, lower ROS levels contributed to the inflammatory pain response via the all-thiol HMGB1/RAGE signaling pathway during the chronic state.	Sulfhydryl Compounds	86-91	advanced glycosylation end product-specific receptor	Mus musculus	98-102
32979223-9	2021	These findings led us to propose that ROS levels modulate RAGE and/or TLR4-mediated inflammatory allodynia by regulating the concentrations of disulfide HMGB1 or all-thiol HMGB1.	Sulfhydryl Compounds	166-171	toll-like receptor 4	Mus musculus	70-74
32979223-9	2021	These findings led us to propose that ROS levels modulate RAGE and/or TLR4-mediated inflammatory allodynia by regulating the concentrations of disulfide HMGB1 or all-thiol HMGB1.	Sulfhydryl Compounds	166-171	high mobility group box 1	Mus musculus	172-177
33679289-0	2020	A Novel SOD1 Intermediate Oligomer, Role of Free Thiols and Disulfide Exchange.	Sulfhydryl Compounds	49-55	superoxide dismutase 1	Homo sapiens	8-12
33626394-5	2021	KEY FINDINGS: Compared with vehicle control, alcohol pretreatment significantly reduced hydrolysis of clopidogrel as a result of significant down-regulation of Nrf2-mediated Ces1 expression (responsible for the formation of clopidogrel carboxylate), increased metabolic activation of clopidogrel due to significant up-regulation of Cyp2c (for the formation of active thiol metabolite H4), and consequently enhanced inhibition of ADP-induced platelet aggregation and activation by clopidogrel.	Sulfhydryl Compounds	367-372	nuclear factor, erythroid derived 2, like 2	Mus musculus	160-164
33626394-5	2021	KEY FINDINGS: Compared with vehicle control, alcohol pretreatment significantly reduced hydrolysis of clopidogrel as a result of significant down-regulation of Nrf2-mediated Ces1 expression (responsible for the formation of clopidogrel carboxylate), increased metabolic activation of clopidogrel due to significant up-regulation of Cyp2c (for the formation of active thiol metabolite H4), and consequently enhanced inhibition of ADP-induced platelet aggregation and activation by clopidogrel.	Sulfhydryl Compounds	367-372	carboxylesterase 1G	Mus musculus	174-178
33664754-2	2021	In this study, the contribution of CBSX proteins to the redox regulation of thiol enzymes in the chloroplast Trx system was evaluated both in vitro and in vivo.	Sulfhydryl Compounds	76-81	thioredoxin	Homo sapiens	109-112
33679157-0	2021	A new electrochemical impedance biosensor based on aromatic thiol for alpha-1 antitrypsin determination.	Sulfhydryl Compounds	60-65	serpin family A member 1	Homo sapiens	70-89
33526831-1	2021	Multi-functionalized fibrous silica KCC-1 (MF-KCC-1) bearing amine, tetrasulfide, and thiol groups was synthesized via a post-functionalization method and fully characterized by several methods such as FTIR, FESEM, EDX-Mapping, TEM, and N2 adsorption-desorption techniques.	Sulfhydryl Compounds	86-91	solute carrier family 12 member 4	Homo sapiens	36-41
33588719-6	2021	TFF1 mainly exists as a monomer with an unusual free thiol group and only minor amounts form a disulfide linked homodimer as well as heterodimers with gastrokine-2 and IgG-Fc-binding protein (FCGBP).	Sulfhydryl Compounds	53-58	trefoil factor 1	Homo sapiens	0-4
33105119-0	2021	pH dependent fluorescence of thiol coated CdSe/CdS quantum dots in an aqueous phase.	Sulfhydryl Compounds	29-34	CDP-diacylglycerol synthase 1	Homo sapiens	42-45
33567524-6	2021	Oxidative stress has been implicated in the pathogenesis of Alzheimer"s disease, and brains with the disease examined in this study also exhibited higher carbonylated proteins, as well as an increased thiol oxidation state of peroxiredoxin 6 (Prx6).	Sulfhydryl Compounds	201-206	peroxiredoxin 6	Homo sapiens	226-241
33539422-12	2021	We also investigated changes in the redox state of HIF-1alpha using PEG-maleimide, which binds to thiols synthesized from disulfide bonds by reduction.	Sulfhydryl Compounds	98-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
33485214-4	2021	A biomimetic system (MPLP), which loads PLP NPs on the surface of bone marrow-derived macrophage (BMDM) via the maleimide-thiol conjugation, is synthesized to effectively deliver PLP, control drug release and activate the tumor-specific immune response in situ.	Sulfhydryl Compounds	122-127	proteolipid protein 1	Homo sapiens	22-25
33485214-4	2021	A biomimetic system (MPLP), which loads PLP NPs on the surface of bone marrow-derived macrophage (BMDM) via the maleimide-thiol conjugation, is synthesized to effectively deliver PLP, control drug release and activate the tumor-specific immune response in situ.	Sulfhydryl Compounds	122-127	proteolipid protein 1	Homo sapiens	40-43
33428920-1	2021	Electrophiles, ubiquitously found in the environment, modify thiol groups of sensor proteins, leading to activation of redox signaling pathways such as the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor E2 related factor 2 (Nrf2) pathway.	Sulfhydryl Compounds	61-66	kelch like ECH associated protein 1	Homo sapiens	156-191
33428920-1	2021	Electrophiles, ubiquitously found in the environment, modify thiol groups of sensor proteins, leading to activation of redox signaling pathways such as the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor E2 related factor 2 (Nrf2) pathway.	Sulfhydryl Compounds	61-66	kelch like ECH associated protein 1	Homo sapiens	193-198
33428920-1	2021	Electrophiles, ubiquitously found in the environment, modify thiol groups of sensor proteins, leading to activation of redox signaling pathways such as the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor E2 related factor 2 (Nrf2) pathway.	Sulfhydryl Compounds	61-66	NFE2 like bZIP transcription factor 2	Homo sapiens	236-240
33328325-7	2021	The pro-migratory effects of MIF depended on lipid raft/caveolae-mediated but not clathrin-mediated endocytosis, on its tautomerase activity and, likely, on its thiol protein oxidoreductase activity.	Sulfhydryl Compounds	161-166	macrophage migration inhibitory factor	Homo sapiens	29-32
33314700-0	2021	A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death.	Sulfhydryl Compounds	2-7	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	38-41
33314700-0	2021	A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death.	Sulfhydryl Compounds	2-7	tumor protein p53	Homo sapiens	61-64
33359085-0	2021	Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.	Sulfhydryl Compounds	107-112	thioredoxin	Homo sapiens	59-70
33359085-0	2021	Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.	Sulfhydryl Compounds	107-112	thioredoxin domain containing 17	Homo sapiens	72-77
33359085-0	2021	Cellular S-denitrosylases: Potential role and interplay of Thioredoxin, TRP14, and Glutaredoxin systems in thiol-dependent protein denitrosylation.	Sulfhydryl Compounds	107-112	glutaredoxin	Homo sapiens	83-95
33075181-0	2021	Blocking Von Willebrand Factor Free-Thiols inhibits binding to collagen under high and pathological shear stress.	Sulfhydryl Compounds	36-42	von Willebrand factor	Homo sapiens	9-30
33075181-1	2021	BACKGROUND: Von Willebrand Factor (VWF) contains a number of free thiols, the majority of which are located in its C-domains, and these have been shown to alter VWF function, However, the impact of free-thiols on function following acute exposure of VWF to collagen under high and pathological shear stress has not been determined.	Sulfhydryl Compounds	66-72	von Willebrand factor	Homo sapiens	12-33
33075181-1	2021	BACKGROUND: Von Willebrand Factor (VWF) contains a number of free thiols, the majority of which are located in its C-domains, and these have been shown to alter VWF function, However, the impact of free-thiols on function following acute exposure of VWF to collagen under high and pathological shear stress has not been determined.	Sulfhydryl Compounds	66-72	von Willebrand factor	Homo sapiens	35-38
33075181-1	2021	BACKGROUND: Von Willebrand Factor (VWF) contains a number of free thiols, the majority of which are located in its C-domains, and these have been shown to alter VWF function, However, the impact of free-thiols on function following acute exposure of VWF to collagen under high and pathological shear stress has not been determined.	Sulfhydryl Compounds	66-72	von Willebrand factor	Homo sapiens	161-164
33075181-1	2021	BACKGROUND: Von Willebrand Factor (VWF) contains a number of free thiols, the majority of which are located in its C-domains, and these have been shown to alter VWF function, However, the impact of free-thiols on function following acute exposure of VWF to collagen under high and pathological shear stress has not been determined.	Sulfhydryl Compounds	66-72	von Willebrand factor	Homo sapiens	161-164
33075181-1	2021	BACKGROUND: Von Willebrand Factor (VWF) contains a number of free thiols, the majority of which are located in its C-domains, and these have been shown to alter VWF function, However, the impact of free-thiols on function following acute exposure of VWF to collagen under high and pathological shear stress has not been determined.	Sulfhydryl Compounds	203-209	von Willebrand factor	Homo sapiens	12-33
33075181-1	2021	BACKGROUND: Von Willebrand Factor (VWF) contains a number of free thiols, the majority of which are located in its C-domains, and these have been shown to alter VWF function, However, the impact of free-thiols on function following acute exposure of VWF to collagen under high and pathological shear stress has not been determined.	Sulfhydryl Compounds	203-209	von Willebrand factor	Homo sapiens	35-38
33075181-4	2021	RESULTS: Blockade of VWF free-thiols reduced VWF mediated platelet capture to collagen in a shear dependent manner, with platelet capture virtually abolished above 5000s-1 and in regions of stenosis in microfluidic channels.	Sulfhydryl Compounds	30-36	von Willebrand factor	Homo sapiens	21-24
33075181-4	2021	RESULTS: Blockade of VWF free-thiols reduced VWF mediated platelet capture to collagen in a shear dependent manner, with platelet capture virtually abolished above 5000s-1 and in regions of stenosis in microfluidic channels.	Sulfhydryl Compounds	30-36	von Willebrand factor	Homo sapiens	45-48
33075181-6	2021	AFM measurements showed that thiol-blockade reduced the life-time and strength of the VWF-collagen bond.	Sulfhydryl Compounds	29-34	von Willebrand factor	Homo sapiens	86-89
33075181-7	2021	Pulling simulations of the VWF-C4 domain demonstrated that with one or two reduced disulphide bonds the C4 domain has increased flexibility and the propensity to undergo free-thiol exchange.	Sulfhydryl Compounds	175-180	von Willebrand factor	Homo sapiens	27-30
33075181-8	2021	CONCLUSIONS: We conclude that free-thiols in the C-domains of VWF enhance the flexibility of the molecule and enable it to withstand high shear forces following collagen binding, demonstrating a previously unrecognised role for VWF free-thiols.	Sulfhydryl Compounds	35-41	von Willebrand factor	Homo sapiens	62-65
33075181-8	2021	CONCLUSIONS: We conclude that free-thiols in the C-domains of VWF enhance the flexibility of the molecule and enable it to withstand high shear forces following collagen binding, demonstrating a previously unrecognised role for VWF free-thiols.	Sulfhydryl Compounds	35-41	von Willebrand factor	Homo sapiens	228-231
33075181-8	2021	CONCLUSIONS: We conclude that free-thiols in the C-domains of VWF enhance the flexibility of the molecule and enable it to withstand high shear forces following collagen binding, demonstrating a previously unrecognised role for VWF free-thiols.	Sulfhydryl Compounds	237-243	von Willebrand factor	Homo sapiens	62-65
33075181-8	2021	CONCLUSIONS: We conclude that free-thiols in the C-domains of VWF enhance the flexibility of the molecule and enable it to withstand high shear forces following collagen binding, demonstrating a previously unrecognised role for VWF free-thiols.	Sulfhydryl Compounds	237-243	von Willebrand factor	Homo sapiens	228-231
32615861-3	2021	The aim of this study was to characterize the degradation-controlled in vitro release kinetics of PTH from the thiol-ene hydrogels, in vivo hydrogel degradation in a subcutaneous implant model, and bone healing in a rat critical size bone defect.	Sulfhydryl Compounds	111-116	parathyroid hormone	Rattus norvegicus	98-101
32615861-7	2021	Treatment of bone defects with the composite thiol-ene hydrogel-PPF scaffold, delivering either 3 or 10 microg of tethered PTH 1-84, was found to increase bridging of critical size bone defects, whereas treatment with 30 microg of tethered PTH resulted in less bone ingrowth into the defect area.	Sulfhydryl Compounds	45-50	parathyroid hormone	Rattus norvegicus	123-131
32615861-7	2021	Treatment of bone defects with the composite thiol-ene hydrogel-PPF scaffold, delivering either 3 or 10 microg of tethered PTH 1-84, was found to increase bridging of critical size bone defects, whereas treatment with 30 microg of tethered PTH resulted in less bone ingrowth into the defect area.	Sulfhydryl Compounds	45-50	parathyroid hormone	Rattus norvegicus	123-126
33526831-1	2021	Multi-functionalized fibrous silica KCC-1 (MF-KCC-1) bearing amine, tetrasulfide, and thiol groups was synthesized via a post-functionalization method and fully characterized by several methods such as FTIR, FESEM, EDX-Mapping, TEM, and N2 adsorption-desorption techniques.	Sulfhydryl Compounds	86-91	solute carrier family 12 member 4	Homo sapiens	43-51
33466919-6	2021	By probing the alternative orientation of PDI with respect to hVKORC1, the functionally related noncovalent complex formed by hVKORC1 and PDI was found, which is proposed to be a first precursor to probe thiol-disulphide exchange reactions between PDI and hVKORC1.	Sulfhydryl Compounds	204-209	prolyl 4-hydroxylase subunit beta	Homo sapiens	42-45
33498669-3	2021	Here, we designed a modular nanoscale system that selectively targets CD44v6-expressing GC cells by the site-oriented conjugation of a new-engineered CD44v6 half-antibody fragment to maleimide-modified polystyrene nanoparticles (PNPs) via an efficient bioorthogonal thiol-Michael addition click chemistry.	Sulfhydryl Compounds	266-271	CD44 molecule (Indian blood group)	Homo sapiens	70-74
33466919-6	2021	By probing the alternative orientation of PDI with respect to hVKORC1, the functionally related noncovalent complex formed by hVKORC1 and PDI was found, which is proposed to be a first precursor to probe thiol-disulphide exchange reactions between PDI and hVKORC1.	Sulfhydryl Compounds	204-209	vitamin K epoxide reductase complex subunit 1	Homo sapiens	62-69
33466919-6	2021	By probing the alternative orientation of PDI with respect to hVKORC1, the functionally related noncovalent complex formed by hVKORC1 and PDI was found, which is proposed to be a first precursor to probe thiol-disulphide exchange reactions between PDI and hVKORC1.	Sulfhydryl Compounds	204-209	vitamin K epoxide reductase complex subunit 1	Homo sapiens	126-133
33466919-6	2021	By probing the alternative orientation of PDI with respect to hVKORC1, the functionally related noncovalent complex formed by hVKORC1 and PDI was found, which is proposed to be a first precursor to probe thiol-disulphide exchange reactions between PDI and hVKORC1.	Sulfhydryl Compounds	204-209	prolyl 4-hydroxylase subunit beta	Homo sapiens	138-141
33466919-6	2021	By probing the alternative orientation of PDI with respect to hVKORC1, the functionally related noncovalent complex formed by hVKORC1 and PDI was found, which is proposed to be a first precursor to probe thiol-disulphide exchange reactions between PDI and hVKORC1.	Sulfhydryl Compounds	204-209	prolyl 4-hydroxylase subunit beta	Homo sapiens	138-141
33466919-6	2021	By probing the alternative orientation of PDI with respect to hVKORC1, the functionally related noncovalent complex formed by hVKORC1 and PDI was found, which is proposed to be a first precursor to probe thiol-disulphide exchange reactions between PDI and hVKORC1.	Sulfhydryl Compounds	204-209	vitamin K epoxide reductase complex subunit 1	Homo sapiens	126-133
33410430-5	2021	However, in the presence of thiocholine (TCh), a thiol-containing compound hydrolyzed from acetylthiocholine (ATCh) by AChE, a stronger coordination interaction between Cu2+ and TCh occurred, resulting in the restoration of the fluorescence of GQD@Tb/GMP ICPs.	Sulfhydryl Compounds	49-54	acetylcholinesterase	Rattus norvegicus	119-123
33416847-6	2021	Redox shift assays using a thiol-modifying reagent indicated that PFK5 is efficiently reduced by a specific type of Trx, namely, Trx-f. PFK5 enzyme activity was lowered with the Trx-f-dependent reduction.	Sulfhydryl Compounds	27-32	phosphofructokinase 5	Arabidopsis thaliana	66-70
33198504-3	2021	RESULTS: We synthesized a tyrosine-based iodoacetamide derivative, N-iodoacetyl L-tyrosine methyl ester (TME-IAM), which reacts with the thiol residue of cysteine identically to that of beta-(4-hydroxyphenyl)ethyl iodoacetamide (HPE-IAM), a commercially available reagent.	Sulfhydryl Compounds	137-142	T-associated maternal effect	Mus musculus	105-108
33416847-6	2021	Redox shift assays using a thiol-modifying reagent indicated that PFK5 is efficiently reduced by a specific type of Trx, namely, Trx-f. PFK5 enzyme activity was lowered with the Trx-f-dependent reduction.	Sulfhydryl Compounds	27-32	thioredoxin H-type 1	Arabidopsis thaliana	116-119
33416847-6	2021	Redox shift assays using a thiol-modifying reagent indicated that PFK5 is efficiently reduced by a specific type of Trx, namely, Trx-f. PFK5 enzyme activity was lowered with the Trx-f-dependent reduction.	Sulfhydryl Compounds	27-32	thioredoxin H-type 1	Arabidopsis thaliana	129-132
33416847-6	2021	Redox shift assays using a thiol-modifying reagent indicated that PFK5 is efficiently reduced by a specific type of Trx, namely, Trx-f. PFK5 enzyme activity was lowered with the Trx-f-dependent reduction.	Sulfhydryl Compounds	27-32	phosphofructokinase 5	Arabidopsis thaliana	136-140
33416847-6	2021	Redox shift assays using a thiol-modifying reagent indicated that PFK5 is efficiently reduced by a specific type of Trx, namely, Trx-f. PFK5 enzyme activity was lowered with the Trx-f-dependent reduction.	Sulfhydryl Compounds	27-32	thioredoxin H-type 1	Arabidopsis thaliana	129-132
33419032-5	2021	The measurement of redox dependence of rWT Ocm thiol-disulfide equilibrium (glutathione redox pair) showed that redox potential of Cys18 for the metal-free and Ca2+-loaded protein is of -168 mV and -176 mV, respectively.	Sulfhydryl Compounds	47-52	oncomodulin	Rattus norvegicus	43-46
33419032-6	2021	Therefore, the conservative thiol of rWT Ocm is prone to disulfide dimerization under physiological redox conditions.	Sulfhydryl Compounds	28-33	oncomodulin	Rattus norvegicus	41-44
33279619-6	2021	We observed MB to significantly impact cellular thiol redox status by oxidizing cellular glutathione and altering the thiol redox status of peroxiredoxin 3 (Prx3, mitochondrial) after acute exposure.	Sulfhydryl Compounds	118-123	peroxiredoxin 3	Homo sapiens	140-155
33241667-4	2021	This study shows that CD4+ TEM cells can be decorated with poly(ethylene glycol)-modified polystyrene nanoparticles using thiol-maleimide coupling chemistry, resulting in the immobilization of  105 nanoparticles per cell as determined by confocal microscopy.	Sulfhydryl Compounds	122-127	CD4 antigen	Mus musculus	22-25
33144263-5	2021	Herein, we attempt to clarify the effects of defined thiol oxidation states on small molecule binding of cytoglobin heme, using cyanide binding to probe the ferric state.	Sulfhydryl Compounds	53-58	cytoglobin	Homo sapiens	105-115
33144263-6	2021	Cyanide binding kinetics to wild-type cytoglobin reveal at least two kinetically distinct subpopulations, depending on thiol oxidation states.	Sulfhydryl Compounds	119-124	cytoglobin	Homo sapiens	38-48
33249742-7	2021	Select metabolites associated with thiol metabolism were similarly affected by GTE and the loss-of-TLR4 signaling.	Sulfhydryl Compounds	35-40	toll-like receptor 4	Mus musculus	99-103
33161042-3	2021	It is believed that conserved cysteines (Cys) in GC1 modulate the enzyme"s activity through thiol-redox modifications.	Sulfhydryl Compounds	92-97	olfactomedin 4	Homo sapiens	49-52
33161042-5	2021	Herein we investigated the novel concept that NO-stimulated GC1 activity is mediated by thiol/disulfide switches and aimed to map the specific Cys that are involved.	Sulfhydryl Compounds	88-93	olfactomedin 4	Homo sapiens	60-63
33249863-5	2021	RyR2 protein levels decreased progressively during the process, and the thiol oxidation proportions of RyR2 were higher in compensated and decompensated stages than in normal stage.	Sulfhydryl Compounds	72-77	ryanodine receptor 2	Rattus norvegicus	103-107
33126056-6	2021	Moreover, partial depletion of thiols with buthionine sulfoximine prevented PKC nitrosylation and the blood pressure effects of oral nitrite.	Sulfhydryl Compounds	31-37	proline rich transmembrane protein 2	Homo sapiens	76-79
33379237-4	2020	Scaffolds were formed via a Michael addition reaction upon the combination of two 8-arm polyethylene glycol (PEG) polymers functionalized with thiol (PEG-8-SH) and acrylate (PEG-8-Acr) end groups.	Sulfhydryl Compounds	143-148	IGF2 antisense RNA	Homo sapiens	150-155
33728852-7	2021	In patients with alcoholic psychosis, Nrf2 level was correlated with both the total antioxidant capacity due to uric acid and the <<thiol>> antioxidant capacity; in patients with psychosis in schizophrenia, Nrf2 level was correlated only with the <<thiol>> antioxidant capacity.	Sulfhydryl Compounds	132-137	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
33728852-7	2021	In patients with alcoholic psychosis, Nrf2 level was correlated with both the total antioxidant capacity due to uric acid and the <<thiol>> antioxidant capacity; in patients with psychosis in schizophrenia, Nrf2 level was correlated only with the <<thiol>> antioxidant capacity.	Sulfhydryl Compounds	132-137	NFE2 like bZIP transcription factor 2	Homo sapiens	207-211
33728852-7	2021	In patients with alcoholic psychosis, Nrf2 level was correlated with both the total antioxidant capacity due to uric acid and the <<thiol>> antioxidant capacity; in patients with psychosis in schizophrenia, Nrf2 level was correlated only with the <<thiol>> antioxidant capacity.	Sulfhydryl Compounds	249-254	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
33728852-7	2021	In patients with alcoholic psychosis, Nrf2 level was correlated with both the total antioxidant capacity due to uric acid and the <<thiol>> antioxidant capacity; in patients with psychosis in schizophrenia, Nrf2 level was correlated only with the <<thiol>> antioxidant capacity.	Sulfhydryl Compounds	249-254	NFE2 like bZIP transcription factor 2	Homo sapiens	207-211
33728852-8	2021	CONCLUSIONS: The correlation between the total and <<thiol>> antioxidant capacity and the level of Nrf2 in mononuclear cells of patients with alcohol delirium indicates the undamaged state of the regulation.	Sulfhydryl Compounds	53-58	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
33575999-1	2021	AIM: To assess and compare the antioxidant capacities of high-grade gliomas (HGG) according to their grades and the presence of isocitrate dehydrogenase 1 (IDH1) mutation using tissue thiol level measurement.	Sulfhydryl Compounds	184-189	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	156-160
33575999-7	2021	When all tumors were compared according to the IDH1 mutation presence, IDH1-negative (IDH1-) HGGs had higher thiol contents than IDH1 mutant (IDH1+) HGGs (p = 0.001).	Sulfhydryl Compounds	109-114	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	71-75
33575999-7	2021	When all tumors were compared according to the IDH1 mutation presence, IDH1-negative (IDH1-) HGGs had higher thiol contents than IDH1 mutant (IDH1+) HGGs (p = 0.001).	Sulfhydryl Compounds	109-114	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	71-75
33575999-7	2021	When all tumors were compared according to the IDH1 mutation presence, IDH1-negative (IDH1-) HGGs had higher thiol contents than IDH1 mutant (IDH1+) HGGs (p = 0.001).	Sulfhydryl Compounds	109-114	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	71-75
33575999-7	2021	When all tumors were compared according to the IDH1 mutation presence, IDH1-negative (IDH1-) HGGs had higher thiol contents than IDH1 mutant (IDH1+) HGGs (p = 0.001).	Sulfhydryl Compounds	109-114	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	71-75
33575999-8	2021	The thiol levels of Grade 4 IDH1- gliomas were statistically significantly higher than of Grade 3 gliomas (p = 0.023), but no statistically significant difference between the thiol levels of Grade 3 and Grade 4 IDH1+ tumors was noted (p = 0.459).	Sulfhydryl Compounds	4-9	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
33575999-9	2021	CONCLUSION: We have demonstrated the higher thiol concentrations of HGGs, particularly IDH1- ones.	Sulfhydryl Compounds	44-49	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	87-91
33414789-1	2020	The thiol isomerase, protein disulfide isomerase (PDI), plays important intracellular roles during protein folding, maintaining cellular function and viability.	Sulfhydryl Compounds	4-9	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	21-48
33414789-1	2020	The thiol isomerase, protein disulfide isomerase (PDI), plays important intracellular roles during protein folding, maintaining cellular function and viability.	Sulfhydryl Compounds	4-9	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	50-53
33409268-4	2020	Variants of BM3Heme, cytochrome C, glucose oxidase, and glutathione reductase were then attached via maleimide-thiol coupling.	Sulfhydryl Compounds	111-116	cytochrome c, somatic	Homo sapiens	21-33
33357178-7	2021	Finally, we took K-Ras4B HVR peptide as an example to test the compatibility of farnesylation reaction at Cys with the N-terminal Sec)2, and the farnesyl group was successfully added to the thiol group of Cys.	Sulfhydryl Compounds	190-195	KRAS proto-oncogene, GTPase	Homo sapiens	17-24
33409268-4	2020	Variants of BM3Heme, cytochrome C, glucose oxidase, and glutathione reductase were then attached via maleimide-thiol coupling.	Sulfhydryl Compounds	111-116	glutathione-disulfide reductase	Homo sapiens	56-77
33027771-5	2020	Thiol modification of beta-CD was carried out using thiourea which served as a thiol donor.	Sulfhydryl Compounds	0-5	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	22-29
33027771-5	2020	Thiol modification of beta-CD was carried out using thiourea which served as a thiol donor.	Sulfhydryl Compounds	79-84	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	22-29
32958252-11	2020	In summary, EdAG"s ability to spontaneously react with endogenous thiols and inhibit hTrx-1 are potentially biochemically relevant in humans.	Sulfhydryl Compounds	66-72	hemogen	Homo sapiens	12-16
32961182-0	2020	Thiol antioxidant thioredoxin reductase: A prospective biochemical crossroads between anticancer and antiparasitic treatments of the modern era.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	18-29
32961182-1	2020	The thiol-based glutathione reductase (GR) and thioredoxin reductase (TrxR) are the major antioxidant enzymes present in various organisms that maintain the internal redox homeostasis.	Sulfhydryl Compounds	4-9	glutathione-disulfide reductase	Homo sapiens	16-37
32961182-1	2020	The thiol-based glutathione reductase (GR) and thioredoxin reductase (TrxR) are the major antioxidant enzymes present in various organisms that maintain the internal redox homeostasis.	Sulfhydryl Compounds	4-9	glutathione-disulfide reductase	Homo sapiens	39-41
32961182-1	2020	The thiol-based glutathione reductase (GR) and thioredoxin reductase (TrxR) are the major antioxidant enzymes present in various organisms that maintain the internal redox homeostasis.	Sulfhydryl Compounds	4-9	thioredoxin	Homo sapiens	47-58
32961182-1	2020	The thiol-based glutathione reductase (GR) and thioredoxin reductase (TrxR) are the major antioxidant enzymes present in various organisms that maintain the internal redox homeostasis.	Sulfhydryl Compounds	4-9	peroxiredoxin 5	Homo sapiens	70-74
32958252-0	2020	Electrophilic reactivity of the Busulfan metabolite, EdAG, towards cellular thiols and inhibition of human thioredoxin-1.	Sulfhydryl Compounds	76-82	hemogen	Homo sapiens	53-57
32958252-4	2020	However, EdAG"s reactions with common cellular thiols such as glutathione (GSH) and l-cysteine are understudied, along with possible inhibition of glutathionylation-dependent enzymes (with active site cysteine residues).	Sulfhydryl Compounds	47-53	hemogen	Homo sapiens	9-13
32958252-6	2020	Using this model, we compared the apparent rates of thiol depletion in the presence of EdAG or arecoline, a toxic constituent of the areca (betel) nut and known GSH depletor.	Sulfhydryl Compounds	52-57	hemogen	Homo sapiens	87-91
33274918-0	2020	Analysis of Hop-Derived Thiols in Beer Using On-Fiber Derivatization in Combination with HS-SPME and GC-MS/MS.	Sulfhydryl Compounds	24-30	HOP homeobox	Homo sapiens	12-15
33201697-6	2020	Cellular NF-kappaB inhibition assays for these lactams were benchmarked against parthenolide and a synthetic alpha-methylene-gamma-lactone showing a positive correlation between thiol reactivity and bioactivity.	Sulfhydryl Compounds	178-183	nuclear factor kappa B subunit 1	Homo sapiens	9-18
33231463-1	2020	The thermal stability of thiol based DNA SAMs prepared on gold surfaces is an important parameter that is correlated to sensor lifetime.	Sulfhydryl Compounds	25-30	methionine adenosyltransferase 1A	Homo sapiens	41-45
33298526-5	2021	Using these reagents, here we have determined how enhanced generation of mitochondrial superoxide and hydrogen peroxide, or disruption of mitochondrial thiol homeostasis affect activation of the Nrf2 system in cells, which was assessed by Nrf2 protein level, nuclear translocation and expression of its target genes.	Sulfhydryl Compounds	152-157	NFE2 like bZIP transcription factor 2	Homo sapiens	195-199
33330868-0	2021	Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies.	Sulfhydryl Compounds	59-64	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	22-27
33330868-0	2021	Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies.	Sulfhydryl Compounds	59-64	angiotensin converting enzyme 2	Homo sapiens	39-43
33330868-4	2021	We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection.	Sulfhydryl Compounds	14-19	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	140-145
33330868-4	2021	We found that thiol-based drugs, cysteamine and WR-1065 (the active metabolite of amifostine) in particular, decrease binding of SARS-CoV-2 spike protein to its receptor, decrease the entry efficiency of SARS-CoV-2 spike pseudotyped virus, and inhibit SARS-CoV-2 live virus infection.	Sulfhydryl Compounds	14-19	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	215-220
33330868-6	2021	One Sentence Summary: Thiol-based drugs decrease binding of SARS-CoV-2 spike protein to its receptor and inhibit SARS-CoV-2 cell entry.	Sulfhydryl Compounds	22-27	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	71-76
33298526-0	2021	Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production.	Sulfhydryl Compounds	49-54	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31302696-9	2020	Given the broad-ranging actions of NRF2, we need to better understand the mechanisms of activation, biological function and regulation of NRF2 and its inhibitor, KEAP1, in different clinical conditions to ensure that modulation of this thiol-based system will not result in major adverse effects.	Sulfhydryl Compounds	236-241	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
31302696-9	2020	Given the broad-ranging actions of NRF2, we need to better understand the mechanisms of activation, biological function and regulation of NRF2 and its inhibitor, KEAP1, in different clinical conditions to ensure that modulation of this thiol-based system will not result in major adverse effects.	Sulfhydryl Compounds	236-241	NFE2 like bZIP transcription factor 2	Homo sapiens	138-142
31302696-9	2020	Given the broad-ranging actions of NRF2, we need to better understand the mechanisms of activation, biological function and regulation of NRF2 and its inhibitor, KEAP1, in different clinical conditions to ensure that modulation of this thiol-based system will not result in major adverse effects.	Sulfhydryl Compounds	236-241	kelch like ECH associated protein 1	Homo sapiens	162-167
33106987-4	2020	We focused on the impact of antioxidants, like NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, that maintain the disulfide-thiol balance in the cell.	Sulfhydryl Compounds	171-176	thioredoxin	Homo sapiens	98-109
33276631-1	2020	NF-E2 p45-related factor 2 (NRF2, encoded in the human by NFE2L2) mediates short-term adaptation to thiol-reactive stressors.	Sulfhydryl Compounds	100-105	NFE2 like bZIP transcription factor 2	Homo sapiens	0-26
33276631-1	2020	NF-E2 p45-related factor 2 (NRF2, encoded in the human by NFE2L2) mediates short-term adaptation to thiol-reactive stressors.	Sulfhydryl Compounds	100-105	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
33276631-1	2020	NF-E2 p45-related factor 2 (NRF2, encoded in the human by NFE2L2) mediates short-term adaptation to thiol-reactive stressors.	Sulfhydryl Compounds	100-105	NFE2 like bZIP transcription factor 2	Homo sapiens	58-64
33276631-2	2020	In normal cells, activation of NRF2 by a thiol-reactive stressor helps prevent, for a limited period of time, the initiation of cancer by chemical carcinogens through induction of genes encoding drug-metabolising enzymes.	Sulfhydryl Compounds	41-46	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
32255262-4	2020	The thiol side-chain of the single vimentin cysteine at position 328 (Cys328) is a direct target of oxidative modifications inside cells.	Sulfhydryl Compounds	4-9	vimentin	Homo sapiens	35-43
33058990-3	2020	In this study, we demonstrated that plasma thiol antioxidant capacity (-SHp) is a useful predictive biomarker associated with future clinical severity using MeHg-intoxicated rats administered 1 mg/kg/day for 4 weeks.	Sulfhydryl Compounds	43-48	nuclear receptor subfamily 0, group B, member 2	Rattus norvegicus	72-75
33087507-0	2020	Glutaminase inhibitors induce thiol-mediated oxidative stress and radio-sensitization in treatment resistant cervical cancers.	Sulfhydryl Compounds	30-35	glutaminase	Homo sapiens	0-11
33170008-5	2020	ABPP on crude cell lysates suggested that general proteome thiol reactivity correlates with cytotoxicity.	Sulfhydryl Compounds	59-64	amyloid beta precursor protein	Homo sapiens	0-4
32822809-7	2020	In this study, we present a comprehensive approach for site-selective conjugation between aminated silica nanoparticles (SiNPs) and the single accessible thiol in human serum albumin (HSA) (66.5 kDa).	Sulfhydryl Compounds	154-159	albumin	Homo sapiens	169-182
33039509-13	2020	CONCLUSION: This study showed that both GnRH agonist and thiol preserved or improved structural changes in the hypothalamus caused by cyclophosphamide in mice, suggesting that using thiol and especially GnRH agonist along with chemotherapy drugs may have protective effects on fertility.	Sulfhydryl Compounds	57-62	gonadotropin releasing hormone 1	Mus musculus	203-207
33039509-13	2020	CONCLUSION: This study showed that both GnRH agonist and thiol preserved or improved structural changes in the hypothalamus caused by cyclophosphamide in mice, suggesting that using thiol and especially GnRH agonist along with chemotherapy drugs may have protective effects on fertility.	Sulfhydryl Compounds	182-187	gonadotropin releasing hormone 1	Mus musculus	40-44
32780264-1	2020	Targeting to obtain better water solubility and stability and less aggregation-caused quenching effects of quantum dots, two kinds of thiol molecules, glutathione and L-cysteine, were firstly united to offer stabilizing ligands for aqueous synthesized CdS quantum dots, which exhibited sensitive aggregation-induced emission properties.	Sulfhydryl Compounds	134-139	CDP-diacylglycerol synthase 1	Homo sapiens	252-255
33106987-4	2020	We focused on the impact of antioxidants, like NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, that maintain the disulfide-thiol balance in the cell.	Sulfhydryl Compounds	171-176	prolyl 4-hydroxylase subunit beta	Homo sapiens	114-141
33245668-7	2021	CF3 increased hepatic non-protein thiol (NPSH) levels and the superoxide dismutase (SOD) activity decreased by a single morphine dose.	Sulfhydryl Compounds	34-39	coagulation factor III	Mus musculus	0-3
33038311-7	2020	We identified the reactive sulfhydryl moiety as that of cysteine, as S-carboxymethylation to block cysteine sulfhydryls prevented NF-kappaB-p65-Cys-alkylation reaction with EGCG.	Sulfhydryl Compounds	27-37	RELA proto-oncogene, NF-kB subunit	Homo sapiens	130-143
33238608-4	2020	Detailed mechanistic studies revealed that both homoleptic and heteroleptic silver complexes strongly and selectively inhibit the selenoenzyme thioredoxin reductase both as isolated enzyme and in human ovarian cancer cells (half inhibition concentration values in the nanomolar range) causing the disruption of cellular thiol-redox homeostasis, and leading to apoptotic cell death.	Sulfhydryl Compounds	320-325	peroxiredoxin 5	Homo sapiens	143-164
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	Sulfhydryl Compounds	190-195	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	Sulfhydryl Compounds	190-195	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	Sulfhydryl Compounds	190-195	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
33238433-9	2020	Blocking enzymatically catalyzed thiol-isomerization decreased plasmin-induced platelet responses, suggesting that plasmin activates platelets in a thiol-dependent manner.	Sulfhydryl Compounds	33-38	plasminogen	Homo sapiens	63-70
33238433-9	2020	Blocking enzymatically catalyzed thiol-isomerization decreased plasmin-induced platelet responses, suggesting that plasmin activates platelets in a thiol-dependent manner.	Sulfhydryl Compounds	33-38	plasminogen	Homo sapiens	115-122
33238433-9	2020	Blocking enzymatically catalyzed thiol-isomerization decreased plasmin-induced platelet responses, suggesting that plasmin activates platelets in a thiol-dependent manner.	Sulfhydryl Compounds	148-153	plasminogen	Homo sapiens	63-70
33238433-9	2020	Blocking enzymatically catalyzed thiol-isomerization decreased plasmin-induced platelet responses, suggesting that plasmin activates platelets in a thiol-dependent manner.	Sulfhydryl Compounds	148-153	plasminogen	Homo sapiens	115-122
32898624-2	2020	The magnitude and duration of S-nitrosylation are governed by the two main thiol reducing systems, the glutathione (GSH) and thioredoxin (Trx) antioxidant systems.	Sulfhydryl Compounds	75-80	thioredoxin	Homo sapiens	138-141
31905314-6	2020	Moreover, combined PRP and CWI were more effective than the isolated treatments to increase catalase activity, also the ratio of reduced/oxidized glutathione, and the non-protein thiols (-SH) group levels.	Sulfhydryl Compounds	179-185	proline rich protein 2-like 1	Rattus norvegicus	19-22
33328889-4	2020	The thiol-dependent antioxidant activity of IRBP maintains the delicate redox balance in the normal retina.	Sulfhydryl Compounds	4-9	retinol binding protein 3	Homo sapiens	44-48
33207555-7	2020	Plasma samples were taken upon admission, and albumin-adjusted plasma-free thiols were determined.	Sulfhydryl Compounds	75-81	albumin	Homo sapiens	46-53
33207555-8	2020	Albumin-adjusted plasma-free thiols were lower in patients with AKI (n = 43, median (interquartile range) 7.28 micromol/g (3.52, 8.95)) compared to patients without AKI (8.50 mumol/g (5.82, 11.28); p < 0.05) upon admission to the ICU.	Sulfhydryl Compounds	29-35	albumin	Homo sapiens	0-7
33207555-9	2020	Higher age (B = -0.72), higher levels of neutrophil gelatinase-associated lipocalin (B = -0.002), creatinine (B = -0.01) and lower serum albumin (B = 0.47) were associated with lower free thiol levels.	Sulfhydryl Compounds	188-193	lipocalin 2	Homo sapiens	41-83
33207555-10	2020	Further, albumin-adjusted free thiol levels were significantly reduced in patients with sepsis (8.30 (5.52-10.64) micromol/g) compared to patients without sepsis (6.95 (3.72-8.92) micromol/g; p < 0.05).	Sulfhydryl Compounds	31-36	albumin	Homo sapiens	9-16
33207555-11	2020	Together, albumin-adjusted plasma-free thiols were significantly reduced in patients with AKI and patients with sepsis compared with patients without AKI and sepsis.	Sulfhydryl Compounds	39-45	albumin	Homo sapiens	10-17
32912630-1	2020	Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex.	Sulfhydryl Compounds	153-158	thioredoxin interacting protein	Homo sapiens	0-31
32912630-1	2020	Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex.	Sulfhydryl Compounds	153-158	thioredoxin interacting protein	Homo sapiens	33-38
32912630-1	2020	Thioredoxin-interacting protein (TXNIP) has multiple disease-associated functions including inducing oxidative stress by inhibiting the anti-oxidant and thiol reducing activity of thioredoxin (TRX), reducing cellular glucose transport, and is a component of the activated inflammasome complex.	Sulfhydryl Compounds	153-158	thioredoxin	Homo sapiens	180-191
33330413-4	2020	Importantly, we have demonstrated that 20 kDa thiol-reactive PEG conjugated by maleimide chemistry to the Cys2 G-CSF variant exhibits leukocyte proliferative activity similar to that of the commercially available G-CSF conjugated with aldehyde PEG in a neutropenia mice model.	Sulfhydryl Compounds	46-51	colony stimulating factor 3 (granulocyte)	Mus musculus	111-116
32886838-2	2020	The catalytic protocol (Cu(MeCN)4 PF6 /dtbbpy) promotes macrocyclization of peptides, dipeptides and tripeptides at ambient temperature (14 examples, 23 73 % yields) via thiols and bromoalkynes, and is chemoselective with regards to terminal alkynes.	Sulfhydryl Compounds	170-176	sperm associated antigen 17	Homo sapiens	34-37
32938215-0	2020	Free Thiol beta2-GPI (beta-2-Glycoprotein-I) Provides a Link Between Inflammation and Oxidative Stress in Atherosclerotic Coronary Artery Disease.	Sulfhydryl Compounds	5-10	apolipoprotein H	Homo sapiens	11-20
33173013-6	2020	Here, we discuss the mechanisms driving ERp44 substrate recognition, with important consequences on the definition of "thiol-mediated quality control".	Sulfhydryl Compounds	119-124	endoplasmic reticulum protein 44	Homo sapiens	40-45
33148149-10	2021	Betain attenuates mechanism of MIF-mediated effects in TAA-induced liver injury, reducing transaminases, -glutamyltranspeptidase, bilirubin, MDA, AOPP, TOS, CRP, IL-6, IFN-g and increasing thiols.	Sulfhydryl Compounds	189-195	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	31-34
32938215-2	2020	beta2-GPI (beta-2-glycoprotein-I) is a circulating plasma protein that undergoes post-translational modification and exists in free thiol as well as oxidized forms.	Sulfhydryl Compounds	132-137	apolipoprotein H	Homo sapiens	0-9
32938215-9	2020	While total beta2-GPI was not associated with stable coronary artery disease, a higher free thiol beta2-GPI was associated with its presence and extent.	Sulfhydryl Compounds	92-97	apolipoprotein H	Homo sapiens	98-107
32938215-10	2020	This finding remained significant after correcting for confounding variables, and free thiol beta2-GPI was a better predictor of stable coronary artery disease than high-sensitivity C-reactive protein.	Sulfhydryl Compounds	87-92	apolipoprotein H	Homo sapiens	93-102
32938215-12	2020	CONCLUSIONS: Free thiol beta2-GPI is a predictor of coronary artery disease presence and extent in stable patients.	Sulfhydryl Compounds	18-23	apolipoprotein H	Homo sapiens	24-33
32938215-13	2020	Free thiol beta2-GPI was a better predictor than high-sensitivity C-reactive protein.	Sulfhydryl Compounds	5-10	apolipoprotein H	Homo sapiens	11-20
32717533-3	2020	The hTRPA1 activity was abolished by the thiol reducing agent TCEP.	Sulfhydryl Compounds	41-46	transient receptor potential cation channel subfamily A member 1	Homo sapiens	4-10
32702157-10	2020	This review updates recent findings in the field and addresses emerging evidence that thiol/disulfide-based reactions mediated by the prothrombotic secreted PDIs are balanced by the transmembrane member of this family, TMX1.	Sulfhydryl Compounds	86-91	thioredoxin-related transmembrane protein 1	Mus musculus	219-223
32643560-1	2020	The fabrication of molecularly imprinted nanoparticles (MIP-NPs) specific for myoglobin by using thiol-ene photopolymerization in miniemulsion was described.	Sulfhydryl Compounds	97-102	myoglobin	Homo sapiens	78-87
33201598-4	2020	Density functional theoretical computations support experimental observations and predict that a beta-elimination mechanism is favored for converting each nucleophile byproduct into a desired thiol-acrylate product, though an SN 2 process can be competitive (i. e. within <2.5 kcal/mol) in less polar solvents.	Sulfhydryl Compounds	192-197	amyloid beta precursor protein	Homo sapiens	95-101
33879435-0	2020	Thiol-disulfide exchange reactions occurring at modified bovine serum albumin detected using ellman"s reagent (5, 5"-dithiobis (2-itrobenzoic acid).	Sulfhydryl Compounds	0-5	albumin	Homo sapiens	64-77
33060708-2	2020	It belongs to the family of peroxidases (referred to as Peroxiredoxins, Prdx"s) that work independently of any prosthetic groups or co-factors, and instead utilize a peroxidatic thiol residue for peroxide reduction.	Sulfhydryl Compounds	178-183	peroxiredoxin 1	Homo sapiens	56-70
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	13-23	nebulin	Homo sapiens	79-86
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	13-23	actinin alpha 1	Homo sapiens	88-101
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	13-23	myosin binding protein C3	Homo sapiens	175-199
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	13-23	titin	Homo sapiens	215-220
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	25-27	nebulin	Homo sapiens	79-86
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	25-27	actinin alpha 1	Homo sapiens	88-101
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	25-27	myosin binding protein C3	Homo sapiens	175-199
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	25-27	titin	Homo sapiens	215-220
33108336-8	2021	We focus on the secreted redox proteins and characterized thiol switches in the ectodomains of membrane proteins, such as integrins and the metalloprotease ADAM17, which are among the best-characterized proteins and discuss their underlying mechanisms and biological implications.	Sulfhydryl Compounds	58-63	ADAM metallopeptidase domain 17	Homo sapiens	156-162
33055209-0	2020	Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of TP53.	Sulfhydryl Compounds	27-32	tumor protein p53	Homo sapiens	117-121
33055209-2	2020	The P47S variant of TP53, which exists primarily in African-descent populations, associates with an elevated abundance of low molecular weight (LMW) thiols, including glutathione (GSH) and coenzyme A (CoA).	Sulfhydryl Compounds	149-155	tumor protein p53	Homo sapiens	20-24
33055209-6	2020	This adaptive metabolic switch is rapid, reversible, and accompanied by thiol-mediated changes in the structures and activities of key glycolytic signaling pathway proteins, including GAPDH and G6PD.	Sulfhydryl Compounds	72-77	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	184-189
33055209-6	2020	This adaptive metabolic switch is rapid, reversible, and accompanied by thiol-mediated changes in the structures and activities of key glycolytic signaling pathway proteins, including GAPDH and G6PD.	Sulfhydryl Compounds	72-77	glucose-6-phosphate dehydrogenase	Homo sapiens	194-198
32739347-3	2020	Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%.	Sulfhydryl Compounds	168-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
32739347-3	2020	Acetylcholinesterase (AChE) is well known to catalyze the hydrolysis of acetylcholine (ATCh) to produce thiocholine, whose affinity is strong enough to capture Cu2+ by thiol (-SH) group from the complex PASP-Cu, resulting in the fluorescence signal of PASP recovers up to 90%.	Sulfhydryl Compounds	168-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
32917772-1	2020	Light activation of thiol enzymes by the thioredoxin (Trx) systems and cyclic electron transport by the PROTON GRADIENT REGULATION 5 (PGR5)-dependent pathway contribute substantially to regulation of photosynthesis.	Sulfhydryl Compounds	20-25	thioredoxin H-type 1	Arabidopsis thaliana	41-52
32917772-1	2020	Light activation of thiol enzymes by the thioredoxin (Trx) systems and cyclic electron transport by the PROTON GRADIENT REGULATION 5 (PGR5)-dependent pathway contribute substantially to regulation of photosynthesis.	Sulfhydryl Compounds	20-25	thioredoxin H-type 1	Arabidopsis thaliana	54-57
32917772-1	2020	Light activation of thiol enzymes by the thioredoxin (Trx) systems and cyclic electron transport by the PROTON GRADIENT REGULATION 5 (PGR5)-dependent pathway contribute substantially to regulation of photosynthesis.	Sulfhydryl Compounds	20-25	proton gradient regulation 5	Arabidopsis thaliana	104-132
32917772-1	2020	Light activation of thiol enzymes by the thioredoxin (Trx) systems and cyclic electron transport by the PROTON GRADIENT REGULATION 5 (PGR5)-dependent pathway contribute substantially to regulation of photosynthesis.	Sulfhydryl Compounds	20-25	proton gradient regulation 5	Arabidopsis thaliana	134-138
32917772-7	2020	We also compared the photoreduction of thiol enzymes between the trx f1f2 and pgr5 trxf1f2 mutants.	Sulfhydryl Compounds	39-44	thioredoxin H-type 1	Arabidopsis thaliana	65-68
32917772-7	2020	We also compared the photoreduction of thiol enzymes between the trx f1f2 and pgr5 trxf1f2 mutants.	Sulfhydryl Compounds	39-44	proton gradient regulation 5	Arabidopsis thaliana	78-82
33250641-7	2020	Amlodipine inhibited GGT enzyme, which participates in the metabolism of extracellular glutathione (GSH) and platinum-GSH-conjugates to a reactive toxic thiol.	Sulfhydryl Compounds	153-158	gamma-glutamyltransferase 1	Rattus norvegicus	21-24
32940035-6	2020	The Zn(II)-IMAC system selectively bound the thiol-containing Zn(II)-ACE1 inhibitors captopril and omapatrilat, and the Fe(III)-IMAC system selectively bound the Fe(II)/(III)-5-LO inhibitor licofelone, demonstrating a remarkable IMAC-metalloenzyme metal ion match.	Sulfhydryl Compounds	45-50	angiotensin I converting enzyme	Homo sapiens	69-73
33096784-3	2020	Plant RPI is the target of diverse post-translational modifications including phosphorylation and thiol-based modifications to presumably adjust its activity to the photosynthetic electron flow.	Sulfhydryl Compounds	98-103	uncharacterized protein	Chlamydomonas reinhardtii	6-9
33060708-2	2020	It belongs to the family of peroxidases (referred to as Peroxiredoxins, Prdx"s) that work independently of any prosthetic groups or co-factors, and instead utilize a peroxidatic thiol residue for peroxide reduction.	Sulfhydryl Compounds	178-183	peroxiredoxin 1	Homo sapiens	72-76
33066147-7	2020	Moreover, correlative light/electron microscopy (CLEM) was achieved using our atmospheric scanning electron microscope (ASEM); radicals formed in liquid by the electron beam caused the thiol-ene click reactions, and excimer fluorescence of the labeled proteins in cells and tissues was visualized by FM.	Sulfhydryl Compounds	185-190	fibromodulin	Homo sapiens	300-302
33053804-6	2020	We speculated that SH48 bearing an alpha,beta-unsaturated carbonyl group could interact with a thiol residue of STAT3, thereby inactivating this transcription factor.	Sulfhydryl Compounds	95-100	signal transducer and activator of transcription 3	Homo sapiens	112-117
32989125-6	2020	This pattern is distinct from the reactive oxygen species (ROS)-mediated toxicity pathway, and an alternative cysteine reaction pathway was revealed by the decreased abundance of proteins (e.g., MT1X) prone to posttranslational thiol modification.	Sulfhydryl Compounds	228-233	metallothionein 1X	Homo sapiens	195-199
32717274-2	2020	While Nrf2 activity largely is governed by posttranslational modification of critical thiol residues in the protein partner and redox sensor Keap1, fine-tuning is provided by additional mechanisms - including epigenetic regulation.	Sulfhydryl Compounds	86-91	NFE2 like bZIP transcription factor 2	Homo sapiens	6-10
32428298-2	2020	PD-404,182 was shown to be a selective covalent inhibitor of HDAC8 that forms mixed disulfides with several cysteine residues and is also able to transform thiol groups to thiocyanates.	Sulfhydryl Compounds	156-161	histone deacetylase 8	Homo sapiens	61-66
32428298-5	2020	Therefore, the inhibition mechanism of HDAC8 by PD-404,182 involves both, covalent modification of thiols as well as ligand mediated disulfide formation.	Sulfhydryl Compounds	99-105	histone deacetylase 8	Homo sapiens	39-44
33052346-6	2020	Oxidative stress has been implicated in the pathogenesis of Alzheimer"s disease, and Alzheimer"s disease brains examined in this study also exhibited higher carbonylated proteins as well as increased thiol oxidation state of peroxiredoxin 6 (Prx6).	Sulfhydryl Compounds	200-205	peroxiredoxin 6	Homo sapiens	225-240
32925168-5	2020	Trx1 and thiol levels were higher in IL-15- than in IL-2-primed NK cells.	Sulfhydryl Compounds	9-14	interleukin 15	Homo sapiens	37-42
32780893-6	2020	Thiols block the angiotensin-converting enzyme 2 thereby hampering penetration of SARS-CoV-2 into cells.	Sulfhydryl Compounds	0-6	angiotensin converting enzyme 2	Homo sapiens	17-48
32925168-5	2020	Trx1 and thiol levels were higher in IL-15- than in IL-2-primed NK cells.	Sulfhydryl Compounds	9-14	interleukin 2	Homo sapiens	52-56
32580013-2	2020	Nrf2 activators previously tested in clinical trials were electrophilic, causing adverse effects due to non-selective and covalent modification of cellular thiols.	Sulfhydryl Compounds	156-162	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Sulfhydryl Compounds	118-123	amyloid beta precursor protein	Homo sapiens	55-65
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Sulfhydryl Compounds	118-123	NFE2 like bZIP transcription factor 2	Homo sapiens	164-168
30961461-1	2020	Chalcones are a type of flavonoids characterized by an alpha-beta unsaturated structural element which may react with thiol groups to activate pathways such as the Nrf2-Keap-1 system.	Sulfhydryl Compounds	118-123	kelch like ECH associated protein 1	Homo sapiens	169-175
33011677-9	2020	In summary, we propose that ADAM17 is able to modulate Trx-1 conformation affecting its activity and intracellular redox state, bringing up a novel possibility for positive regulation of thiol isomerase activity in the cell by mammalian metalloproteinases.	Sulfhydryl Compounds	187-192	ADAM metallopeptidase domain 17	Homo sapiens	28-34
32618039-3	2020	Glutaredoxin 1 (Grx1) is a thiol/disulfide oxidoreductase that catalyzes the deglutathionylation of proteins and is important for regulation of cellular protein thiol redox homeostasis.	Sulfhydryl Compounds	27-32	glutaredoxin	Homo sapiens	0-14
32618039-3	2020	Glutaredoxin 1 (Grx1) is a thiol/disulfide oxidoreductase that catalyzes the deglutathionylation of proteins and is important for regulation of cellular protein thiol redox homeostasis.	Sulfhydryl Compounds	27-32	glutaredoxin	Homo sapiens	16-20
32905883-3	2020	Here we show that motor abnormalities prior to neuronal loss in this model are associated with extensive alpha-Synuclein-dependent cellular thiol oxidation.	Sulfhydryl Compounds	140-145	synuclein alpha	Rattus norvegicus	105-120
33011677-9	2020	In summary, we propose that ADAM17 is able to modulate Trx-1 conformation affecting its activity and intracellular redox state, bringing up a novel possibility for positive regulation of thiol isomerase activity in the cell by mammalian metalloproteinases.	Sulfhydryl Compounds	187-192	thioredoxin	Homo sapiens	55-60
32969502-3	2021	For the determination of ACE, thiol modified primary aptamer (Apt1) was selected by using the SELEX method and immobilized on the surface of the poly(5-amino-2-mercapto-1,3,4-thiadiazole (P(AMT)) and AuNPs modified SPE (SPE/P(AMT)/AuNPs) via Au-S bonding.	Sulfhydryl Compounds	30-35	lysophospholipase 1	Homo sapiens	62-66
31388672-5	2020	Previous studies showed that glutathione (GSH) is one such thiols, and that cellular gamma-glutamyltransferase (GGT) can efficiently potentiate GSH-dependent iron redox cycling and consequent oxidative stress.	Sulfhydryl Compounds	59-65	gamma-glutamyltransferase light chain family member 3	Homo sapiens	85-110
31388672-5	2020	Previous studies showed that glutathione (GSH) is one such thiols, and that cellular gamma-glutamyltransferase (GGT) can efficiently potentiate GSH-dependent iron redox cycling and consequent oxidative stress.	Sulfhydryl Compounds	59-65	gamma-glutamyltransferase light chain family member 3	Homo sapiens	112-115
32652583-5	2020	CB RNA sequencing data indicate all-thiol HMGB1-mediated upregulation of immune-related biological pathways.	Sulfhydryl Compounds	36-41	high mobility group box 1	Rattus norvegicus	42-47
32760956-5	2020	Using the thiol groups left after removing templates, PIR could be introduced as the 1st PIM.	Sulfhydryl Compounds	10-15	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	89-92
33015465-4	2020	Importantly, both BSA and human serum albumin (HSA) could enhance the peroxidase-like activity of Cu2+, which provided a new sensing platform for distinguishing BSA and HSA from other thiol-containing biomolecules.	Sulfhydryl Compounds	184-189	albumin	Homo sapiens	32-45
32933054-5	2020	In the full length hTRPA1, the labeling of different cysteines ranged from nil up to 95% already at the lowest concentration of NMM, suggesting large differences in reactivity of the thiols.	Sulfhydryl Compounds	183-189	transient receptor potential cation channel subfamily A member 1	Homo sapiens	19-25
32819601-5	2020	Original Ag2S QDs was obtained by mixing sodium sulfide and silver nitrate in a thiol-terminated polyethylene glycol (mPEG-SH) solution.	Sulfhydryl Compounds	80-85	angiotensin II receptor, type 1a	Mus musculus	9-13
32971812-4	2020	The data from the molten globule-like structures of ribonuclease, lysozyme, bovine serum albumin and chymotrypsinogen identified new speeding agents, i.e., hydrophobic/electrostatic interactions and productive complex formations involving the protein and thiol reagent, which were able to confer exceptional reactivity to structural cysteines which were only intended to form disulfides.	Sulfhydryl Compounds	255-260	lysozyme	Homo sapiens	66-74
32971812-4	2020	The data from the molten globule-like structures of ribonuclease, lysozyme, bovine serum albumin and chymotrypsinogen identified new speeding agents, i.e., hydrophobic/electrostatic interactions and productive complex formations involving the protein and thiol reagent, which were able to confer exceptional reactivity to structural cysteines which were only intended to form disulfides.	Sulfhydryl Compounds	255-260	albumin	Homo sapiens	83-96
32910125-2	2020	We employed 1.9 nm Au nanoparticles decorated with thiol ligands bearing a TACN (1,4,7-triazacyclononane) headgroup to encapsulate FMN (riboflavin-5"-phosphate).	Sulfhydryl Compounds	51-56	formin 1	Homo sapiens	131-134
32787104-1	2020	Synthetic triterpenoids including CDDO, its methyl ester (CDDO-Me, bardoxolone methyl), and its imidazolide (CDDO-Im) enhance Nrf2-mediated anti-oxidant and anti-inflammatory activity in many diseases by reacting with thiols on the adaptor protein, Keap1.	Sulfhydryl Compounds	218-224	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
32652583-12	2020	Differential gene expression analysis showed all-thiol HMGB1-driven upregulation of a number of prominent pro-inflammatory markers including Il1alpha and Il1beta.	Sulfhydryl Compounds	49-54	high mobility group box 1	Rattus norvegicus	55-60
32652583-12	2020	Differential gene expression analysis showed all-thiol HMGB1-driven upregulation of a number of prominent pro-inflammatory markers including Il1alpha and Il1beta.	Sulfhydryl Compounds	49-54	interleukin 1 alpha	Rattus norvegicus	141-149
32654268-8	2020	RP1, administered before or after irradiation, alleviated TBI and PBI-BM5-induced TJ disruption, barrier dysfunction, and endotoxemia accompanied by protein thiol oxidation and downregulation of antioxidant gene expression, cofilin activation, and remodeling of the actin cytoskeleton.	Sulfhydryl Compounds	157-162	retinitis pigmentosa 1 (human)	Mus musculus	0-3
32652583-12	2020	Differential gene expression analysis showed all-thiol HMGB1-driven upregulation of a number of prominent pro-inflammatory markers including Il1alpha and Il1beta.	Sulfhydryl Compounds	49-54	interleukin 1 alpha	Rattus norvegicus	154-161
32558346-5	2020	RESULTS: Protein-adjusted serum free thiols were significantly reduced in subjects with FLI>=60 (n=1,651).	Sulfhydryl Compounds	37-43	FLII actin remodeling protein	Homo sapiens	88-91
30688119-2	2020	MATERIALS AND METHODS: The activity of delta-aminolevulinate dehydratase (delta-ALA-D) was analyzed as an indirect marker of oxidative stress, as well as the quantification of thiobarbituric acid reactive substances (TBARS), protein thiol groups (P-SH) and nonprotein thiol groups (NP-SH), vitamin C (VIT C) and catalase activity (CAT) in maternal blood samples from twin (n = 30) and single (n = 30) pregnancies.	Sulfhydryl Compounds	233-238	aminolevulinate dehydratase	Homo sapiens	74-85
30688119-2	2020	MATERIALS AND METHODS: The activity of delta-aminolevulinate dehydratase (delta-ALA-D) was analyzed as an indirect marker of oxidative stress, as well as the quantification of thiobarbituric acid reactive substances (TBARS), protein thiol groups (P-SH) and nonprotein thiol groups (NP-SH), vitamin C (VIT C) and catalase activity (CAT) in maternal blood samples from twin (n = 30) and single (n = 30) pregnancies.	Sulfhydryl Compounds	268-273	aminolevulinate dehydratase	Homo sapiens	74-85
32558346-6	2020	In multivariable logistic regression analyses, protein-adjusted serum free thiols were associated with NAFLD (FLI>=60) (OR per doubling of concentration: 0.78 [95% CI 0.64-0.96], P=0.016) even when adjusted for potential confounding factors, including systolic blood pressure, diabetes, current smoking, use of alcohol, and total cholesterol (OR 0.80 [95% CI 0.65-0.99], P=0.04).	Sulfhydryl Compounds	75-81	FLII actin remodeling protein	Homo sapiens	110-113
32558346-9	2020	Longitudinally, protein-adjusted serum free thiols were significantly associated with the risk of all-cause mortality in subjects with NAFLD (FLI>=60) (HR 0.27 [95% CI 0.17-0.45], P<0.001).	Sulfhydryl Compounds	44-50	FLII actin remodeling protein	Homo sapiens	142-145
32498902-11	2020	The application of ICP-MS together with efficient separation/pre-concentration of analyte on thiol-functionalized MCM-41 sorbents allows to determine Pd in environmental water samples at pg mL-1 level.	Sulfhydryl Compounds	93-98	L1 cell adhesion molecule	Mus musculus	190-194
32498834-7	2020	This biosensor uses a synthetic GPI phosphoglycan bioreceptor immobilized on screen-printed gold electrodes through a linear alkane thiol phosphodiester.	Sulfhydryl Compounds	132-137	glucose-6-phosphate isomerase	Homo sapiens	32-35
32570189-4	2020	Unlike HOCl, HOSCN can be detoxified by thioredoxin reductase, and reacts selectively with thiols to result in reversible modifications, which could potentially reduce the extent of MPO-induced damage during chronic inflammation.	Sulfhydryl Compounds	91-97	myeloperoxidase	Homo sapiens	182-185
32329917-6	2020	IRC7 gene could be proposed as target for the selection of S. cerevisiae strains to increase thiols content in wine.	Sulfhydryl Compounds	93-99	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	0-4
32878074-1	2020	Thioredoxins (Trxs) and thioredoxin reductases (TrxRs) encompass a highly complex network involved in sustaining thiol-based redox homeostasis in plant tissues.	Sulfhydryl Compounds	113-118	LOC101027257	Zea mays	24-35
32908689-13	2020	Conclusion: The results are congruent with the following proposed sequence of events leading to a protective response of the organism during the pathogenesis of primary pterygium: a decreased level of eNOS provokes a decline in the level of NO in pterygium tissue, which then leads to reduced S-nitrosylation of GSH or other thiols and possibly to the modulation of the intracellular level of GSH through synthesis and/or mobilization from other tissues.	Sulfhydryl Compounds	325-331	nitric oxide synthase 3	Homo sapiens	201-205
32785321-1	2020	1,3-Cyclohexandione derived cyclic ketals and thiol ketals were used as O- and S-nucleophiles, respectively, for the ring opening of donor-acceptor cyclopropanes catalyzed by Cu(OTf)2 and a series of functionalized alkylene glycol diethers and dithiol diethers were obtained in good to high yields under mild conditions.	Sulfhydryl Compounds	46-51	POU class 2 homeobox 2	Homo sapiens	175-183
32072360-6	2020	In conclusion, GSTP is confirmed to functionally interact with Nrf2 and to have a prominent position in the pecking order of factors that control both the Nrf2-dependent and independent response of cellular thiols to alkylating agents.	Sulfhydryl Compounds	207-213	nuclear factor, erythroid derived 2, like 2	Mus musculus	63-67
32343292-5	2020	An off-stoichiometry thiol-ene Michael addition between PEGalphaMA (8-arm, 10 kg mol-1) and the clickable dECM resulted in hydrogels with an elastic modulus of E = 3.6 +- 0.24 kPa, approximating healthy lung tissue (1-5 kPa).	Sulfhydryl Compounds	21-26	modifier of LPS-response 1	Mus musculus	81-86
32824562-5	2020	Cysteine and, at a lesser extent, homocysteine represent the most abundant thiol bound to HSA.	Sulfhydryl Compounds	75-80	albumin	Homo sapiens	90-93
31910038-2	2020	This review addresses emerging evidence that exported thiol oxidoreductases(TOR) such as thioredoxin, protein disulfide isomerases, QSOX1 and peroxiredoxins, composing a peri/epicellular (pec)TOR pool, mediates relevant signaling.	Sulfhydryl Compounds	54-59	RAR related orphan receptor C	Homo sapiens	76-79
31910038-2	2020	This review addresses emerging evidence that exported thiol oxidoreductases(TOR) such as thioredoxin, protein disulfide isomerases, QSOX1 and peroxiredoxins, composing a peri/epicellular (pec)TOR pool, mediates relevant signaling.	Sulfhydryl Compounds	54-59	thioredoxin	Homo sapiens	89-100
31910038-2	2020	This review addresses emerging evidence that exported thiol oxidoreductases(TOR) such as thioredoxin, protein disulfide isomerases, QSOX1 and peroxiredoxins, composing a peri/epicellular (pec)TOR pool, mediates relevant signaling.	Sulfhydryl Compounds	54-59	quiescin sulfhydryl oxidase 1	Homo sapiens	132-137
31910038-2	2020	This review addresses emerging evidence that exported thiol oxidoreductases(TOR) such as thioredoxin, protein disulfide isomerases, QSOX1 and peroxiredoxins, composing a peri/epicellular (pec)TOR pool, mediates relevant signaling.	Sulfhydryl Compounds	54-59	RAR related orphan receptor C	Homo sapiens	192-195
31910038-5	2020	TOR catalytic pathways, displaying common patterns, culminate in substrate thiol reduction, oxidation or isomerization.	Sulfhydryl Compounds	75-80	RAR related orphan receptor C	Homo sapiens	0-3
32072360-0	2020	Glutathione S-transferase P influences the Nrf2-dependent response of cellular thiols to seleno-compounds.	Sulfhydryl Compounds	79-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	43-47
32072360-3	2020	GSTP1-1 gene ablation was confirmed to upregulate Nrf2 activity and to increase Cys uptake and the de novo biosynthesis of reduced glutathione (GSH) that was readily released in the extracellular medium together with other cellular thiols.	Sulfhydryl Compounds	232-238	glutathione S-transferase, pi 1	Mus musculus	0-7
32072360-3	2020	GSTP1-1 gene ablation was confirmed to upregulate Nrf2 activity and to increase Cys uptake and the de novo biosynthesis of reduced glutathione (GSH) that was readily released in the extracellular medium together with other cellular thiols.	Sulfhydryl Compounds	232-238	nuclear factor, erythroid derived 2, like 2	Mus musculus	50-54
32823937-5	2020	We summarize the recent understanding of the KEAP1/NRF2 signaling pathway, which is a thiol-based sensor-effector apparatus, with particular focuses on epidermal differentiation in the context of the gene-environment interaction, the structure/function principles involved in KEAP1/NRF2 signaling, lessons from mouse models, and their pathological implications.	Sulfhydryl Compounds	86-91	kelch-like ECH-associated protein 1	Mus musculus	45-50
32823937-5	2020	We summarize the recent understanding of the KEAP1/NRF2 signaling pathway, which is a thiol-based sensor-effector apparatus, with particular focuses on epidermal differentiation in the context of the gene-environment interaction, the structure/function principles involved in KEAP1/NRF2 signaling, lessons from mouse models, and their pathological implications.	Sulfhydryl Compounds	86-91	nuclear factor, erythroid derived 2, like 2	Mus musculus	51-55
32401400-0	2020	Pt-S Bond Mediated Nanoflares for High-Fidelity Intracellular Applications by Avoiding Thiol Cleavage.	Sulfhydryl Compounds	87-92	6-pyruvoyltetrahydropterin synthase	Homo sapiens	0-4
32401400-3	2020	Instead of replacing the thiol by a carbene or selenol for stronger adsorption, we herein communicate that Pt-S bond is much more stable, fully avoiding cleavage by biothiols.	Sulfhydryl Compounds	25-30	6-pyruvoyltetrahydropterin synthase	Homo sapiens	107-111
32072360-6	2020	In conclusion, GSTP is confirmed to functionally interact with Nrf2 and to have a prominent position in the pecking order of factors that control both the Nrf2-dependent and independent response of cellular thiols to alkylating agents.	Sulfhydryl Compounds	207-213	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
32572387-2	2020	However, toxicological effects associated with inhibition of thiol-containing enzymes, such as the delta-aminolevulinic acid dehydratase (delta-AlaD), have been described.	Sulfhydryl Compounds	61-66	aminolevulinate dehydratase	Homo sapiens	99-136
32572387-2	2020	However, toxicological effects associated with inhibition of thiol-containing enzymes, such as the delta-aminolevulinic acid dehydratase (delta-AlaD), have been described.	Sulfhydryl Compounds	61-66	aminolevulinate dehydratase	Homo sapiens	138-148
32729144-4	2020	Based on the different behavior of the CNA-2G monomers and CNA-2G oligomers with two or more pendant nucleobases in photopolymerization, an unusual thiol-ene chain-growth propagation mechanism is observed for the former and a common thiol-ene step-growth propagation mechanism for the latter.	Sulfhydryl Compounds	148-153	keratocan	Homo sapiens	39-44
32563966-4	2020	A series of novel triazolyl pyrazole derivatives (10a-y) in which thiol bearing triazole moiety as the zinc binding functional group was introduced to a pyrazole based pharmacophore was synthesized and evaluated as potent and selective inhibitors of h-TNAP over h-NPP1.	Sulfhydryl Compounds	66-71	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	264-268
32802063-0	2020	Rapid SERS Detection of Thiol-Containing Natural Products in Culturing Complex.	Sulfhydryl Compounds	24-29	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	6-10
32729144-4	2020	Based on the different behavior of the CNA-2G monomers and CNA-2G oligomers with two or more pendant nucleobases in photopolymerization, an unusual thiol-ene chain-growth propagation mechanism is observed for the former and a common thiol-ene step-growth propagation mechanism for the latter.	Sulfhydryl Compounds	233-238	keratocan	Homo sapiens	39-44
32536603-7	2020	In E. coli, the most significant target of IR by a wide margin was glyceraldehyde 3"-phosphate dehydrogenase (GAPDH), in which the thiol side chain of the catalytic Cys residue was oxidized to sulfonic acid.	Sulfhydryl Compounds	131-136	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	110-115
32632184-5	2020	We combine synthetic thiol-reactive nucleotide derivatives with recombinantly produced Fic enzymes containing strategically placed cysteines in their active sites to yield reactive binary probes for covalent substrate capture.	Sulfhydryl Compounds	21-26	C-C motif chemokine ligand 7	Homo sapiens	87-90
32365245-1	2020	Thiol-based redox-regulation is vital to coordinate chloroplast functions depending on illumination and is well investigated for thioredoxin-dependent processes.	Sulfhydryl Compounds	0-5	thioredoxin H-type 1	Arabidopsis thaliana	129-140
32677157-4	2020	In addition, glutathione (GSH) depletion through disulfide-thiol exchange leads to the inactivation of glutathione peroxide 4 (GPX4), which results in a further increase in LPO content.	Sulfhydryl Compounds	59-64	glutathione peroxidase 4	Mus musculus	127-131
32677157-4	2020	In addition, glutathione (GSH) depletion through disulfide-thiol exchange leads to the inactivation of glutathione peroxide 4 (GPX4), which results in a further increase in LPO content.	Sulfhydryl Compounds	59-64	lactoperoxidase	Mus musculus	173-176
32732254-6	2020	Reduction of 2CPA then inactivates its peroxidase activity, suppressing the peroxide detoxification machinery, whereas the activation of SAT1 promotes thiol synthesis and builds up reduction capacity, which in turn triggers the retrograde regulation of defense gene expressions against abiotic stress.	Sulfhydryl Compounds	151-156	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	137-141
32615756-6	2020	According to their prominent organoleptic and distinguishing roles, these two thiols can be regarded as flavor markers for SSB.	Sulfhydryl Compounds	78-84	small RNA binding exonuclease protection factor La	Homo sapiens	123-126
32699335-5	2020	Since conjugation of poly(ethylene) glycol (PEG) has been known to improve the biological properties of biomolecules, therefore, we further attempted to prepare PEG-conjugated variant of cryptdin-2 using thiol specific PEGylation.	Sulfhydryl Compounds	204-209	defensin, alpha, 12	Mus musculus	187-197
32539053-5	2020	In order to avoid this issue, new reactive thiol residues were therefore engineered at sites distant to the heme group and the alpha/beta dimer/dimer interface.	Sulfhydryl Compounds	43-48	amyloid beta precursor protein	Homo sapiens	127-137
32097855-0	2020	Thiol-functionalized magnetic covalent organic frameworks by a cutting strategy for efficient removal of Hg2+ from water.	Sulfhydryl Compounds	0-5	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	105-108
32843933-18	2020	However, a significant negative correlation was observed between visfatin and total with native thiol (P < 0.005, r = -0.338), (P < 0.005, r = -0.448).	Sulfhydryl Compounds	96-101	nicotinamide phosphoribosyltransferase	Homo sapiens	65-73
32409143-9	2020	The HO-1 induction was inhibited by a ROS scavenger N-acetylcysteine (NAC), thiol-containing antioxidants (glutathione [GSH] and dithiothreitol [DTT]), JNK and p38 MAPK inhibitors, and nuclear transport inhibitor leptomycin.	Sulfhydryl Compounds	76-81	heme oxygenase 1	Rattus norvegicus	4-8
32389478-3	2020	First, we tested the thiol-disulfide bond interchange between beta-LG and MFGM by heating raw milk (87 C, 8 min) in the presence of different reagents capable of preventing this interaction, and then evaluated the presence of beta-LG in resulting MFGM preparations by sodium dodecyl sulfate-PAGE.	Sulfhydryl Compounds	21-26	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	74-78
32647651-9	2020	15d-PGJ2-induced inactivation of IKKbeta was also attributable to its covalent thiol modification at the cysteine 179 residue of IKKbeta.	Sulfhydryl Compounds	79-84	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	33-40
32647651-9	2020	15d-PGJ2-induced inactivation of IKKbeta was also attributable to its covalent thiol modification at the cysteine 179 residue of IKKbeta.	Sulfhydryl Compounds	79-84	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	129-136
32437124-4	2020	We herein report the development of a colorimetric assay based on gold nanoparticles (AuNPs), when capped with suitably designed thiol-modified antisense oligonucleotides (ASOs) specific for N-gene (nucleocapsid phosphoprotein) of SARS-CoV-2, could be used for diagnosing positive COVID-19 cases within 10 min from the isolated RNA samples.	Sulfhydryl Compounds	129-134	nucleocapsid phosphoprotein	Severe acute respiratory syndrome coronavirus 2	199-211
32576932-0	2020	Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry.	Sulfhydryl Compounds	56-61	stromal interaction molecule 2	Homo sapiens	83-113
32576932-3	2020	However, the effects of thiol modifications on STIM2 during nitrosative stress and their role in regulating basal Ca2+ levels remain unknown.	Sulfhydryl Compounds	24-29	stromal interaction molecule 2	Homo sapiens	47-52
32573231-3	2020	Herein, a chemical proteomic method to quantify site-specific cysteine reactivity using a maleimide-activated, thiol-reactive probe (N-propargylmaleimide, NPM) is described.	Sulfhydryl Compounds	111-116	nucleophosmin 1	Homo sapiens	155-158
32548971-3	2020	Subsequently, polyethylene glycolated fluorescein isothiocyanate (FITC-PEG) is incorporated into the COFs via the exchange reactions between the disulfide in insulin chains and the thiol in FITC-PEG to afford a robust nano-assembly (FITC-PEG-COF@Ins-GOx).	Sulfhydryl Compounds	181-186	hydroxyacid oxidase 1, liver	Mus musculus	250-253
32610453-0	2020	A DVD-MoS2/Ag2S/Ag Nanocomposite Thiol-Conjugated with Porphyrins for an Enhanced Light-Mediated Hydrogen Evolution Reaction.	Sulfhydryl Compounds	33-38	angiotensin II receptor type 1	Homo sapiens	11-15
32610453-2	2020	Herein, we present the conjugation of this MoS2/Ag2S/Ag-DVD nanocomposite with thiol-terminated tetraphenylporphyrins, taking advantage of the grafting of thiol groups through covalent S-S bridges, for integrating the well-known porphyrins photoactivity into the nanocomposite.	Sulfhydryl Compounds	79-84	angiotensin II receptor type 1	Homo sapiens	48-52
32610453-2	2020	Herein, we present the conjugation of this MoS2/Ag2S/Ag-DVD nanocomposite with thiol-terminated tetraphenylporphyrins, taking advantage of the grafting of thiol groups through covalent S-S bridges, for integrating the well-known porphyrins photoactivity into the nanocomposite.	Sulfhydryl Compounds	155-160	angiotensin II receptor type 1	Homo sapiens	48-52
32630599-8	2020	Only recently, gastric TFF1 was demonstrated to occur predominantly in monomeric forms with an unusual free thiol group.	Sulfhydryl Compounds	108-113	trefoil factor 1	Mus musculus	23-27
32656452-6	2020	In this study, the role of thiol-disulfide balance on the interactions between SARS-CoV/CoV-2 spike proteins and ACE2 was investigated using molecular dynamics simulations.	Sulfhydryl Compounds	27-32	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	94-99
32656452-6	2020	In this study, the role of thiol-disulfide balance on the interactions between SARS-CoV/CoV-2 spike proteins and ACE2 was investigated using molecular dynamics simulations.	Sulfhydryl Compounds	27-32	angiotensin converting enzyme 2	Homo sapiens	113-117
32656452-7	2020	The study revealed that the binding affinity was significantly impaired when all of the disulfide bonds of both ACE2 and SARS-CoV/CoV-2 spike proteins were reduced to thiol groups.	Sulfhydryl Compounds	167-172	angiotensin converting enzyme 2	Homo sapiens	112-116
32656452-7	2020	The study revealed that the binding affinity was significantly impaired when all of the disulfide bonds of both ACE2 and SARS-CoV/CoV-2 spike proteins were reduced to thiol groups.	Sulfhydryl Compounds	167-172	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	136-141
32119934-0	2020	Thiol-mediated and catecholamine-enhanced multimerization of a cerebrovascular disease enriched fragment of NOTCH3.	Sulfhydryl Compounds	0-5	notch receptor 3	Homo sapiens	108-114
32526859-4	2020	Mutations of the FGF2 WT protein were designed to obtain variants with a single surface-exposed reactive cysteine for the chemical conjugation via maleimide-thiol reaction with bis-functionalized linear PEG linkers.	Sulfhydryl Compounds	157-162	fibroblast growth factor 2	Homo sapiens	17-21
32369051-8	2020	The disulfide LMWG loaded with a thiol-containing protein (bovine serum albumin) features sustained release in vitro, whereas a dextran of the same molecular weight, lacking a thiol biomolecule, shows quick release.	Sulfhydryl Compounds	33-38	albumin	Homo sapiens	66-79
32253061-3	2020	To minimize undesirable reactivity, we have strategically blocked the thiol moiety in DTC with a cleavable p-aminobenzyl (pAB) group linked to peptide substrates recognized by prostate specific antigen (PSA).	Sulfhydryl Compounds	70-75	kallikrein related peptidase 3	Homo sapiens	203-206
31919789-8	2020	Because of presence cysteine in both side of S2P peptide, maleimide formed a thiolether linkage by thiol group of cysteine.	Sulfhydryl Compounds	77-82	membrane bound transcription factor peptidase, site 2	Homo sapiens	45-48
31713999-5	2020	However, it is unknown why FAD of Erv1 has such a low potential compared with other sulfhydryl oxidases, and why the shuttle disulphide has a potential as low as many of the stable structural disulphides of the substrates of MIA pathway.	Sulfhydryl Compounds	84-94	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	34-38
32172034-3	2020	In this study, linearly ordered collagen scaffold (LOCS) was modified with N-cadherin through a two-step cross-linking between thiol and amino group.	Sulfhydryl Compounds	127-132	cadherin 2	Rattus norvegicus	75-85
31435697-0	2020	Copper-mediated thiol potentiation and mutagenesis-guided modeling suggest a highly conserved copper-binding motif in human OR2M3.	Sulfhydryl Compounds	16-21	olfactory receptor family 2 subfamily M member 3	Homo sapiens	124-129
32006234-9	2020	Thiol antioxidants such as N-acetyl cysteine and glutathione reduced the neurotoxicity of 15d-PGJ2 but enhanced that of the anti-NSE antibody.	Sulfhydryl Compounds	0-5	enolase 2	Homo sapiens	129-132
32326777-3	2020	Thioredoxin-1 (Trx-1) is a small ubiquitous thiol protein with redox/inflammation modulatory properties relevant to the pathogenesis of sepsis.	Sulfhydryl Compounds	44-49	thioredoxin	Homo sapiens	0-13
32326777-3	2020	Thioredoxin-1 (Trx-1) is a small ubiquitous thiol protein with redox/inflammation modulatory properties relevant to the pathogenesis of sepsis.	Sulfhydryl Compounds	44-49	thioredoxin	Homo sapiens	15-20
32330046-1	2020	Surface and tip-enhanced Raman spectroscopies in total internal reflection (TIR-SERS and TIR-TERS) are used to characterize the oxidation, spin, and ligation state of cytochrome c (Cc) molecules electrostatically bound on a hydrophilic thiol self-assembled monolayer.	Sulfhydryl Compounds	236-241	cytochrome c, somatic	Homo sapiens	167-179
32113527-0	2020	Electrochemical genosensor for Klotho detection based on aliphatic and aromatic thiols self-assembled monolayers.	Sulfhydryl Compounds	80-86	klotho	Homo sapiens	31-37
32092292-8	2020	These results suggest that the changes of the cellular thiol-dependent redox environment regulated by TXNRD1 is a major event in the adverse effects of cisplatin in kidney.	Sulfhydryl Compounds	55-60	thioredoxin reductase 1	Homo sapiens	102-108
31856407-9	2020	This effect might be regulated by the changes in the number of redox-active thiol groups via formate dehydrogenase H, which might be directly related to proton ATPase FO subunit.	Sulfhydryl Compounds	76-81	ATPase	Escherichia coli	160-166
32151745-1	2020	Peroxiredoxins (Prxs) are an unusual family of thiol-specific peroxidases that possess a binding site for H2O2 and rely on a conserved cysteine residue for rapid reaction with H2O2.	Sulfhydryl Compounds	47-52	peroxiredoxin 1	Homo sapiens	0-14
32312386-5	2020	In the detection of thrombin, the selected aptamer probe with a stem-loop structure was labeled with tetraferrocene at the 3" terminal and thiol at the 5" terminal, respectively.	Sulfhydryl Compounds	139-144	coagulation factor II, thrombin	Homo sapiens	20-28
32312386-7	2020	However, upon treatment with the target protein of thrombin the stem-loop structure opened, promoting rapid attachment of the thiol group to the electrode interface generating Au-S self-assembly with the action of potential-assistance.	Sulfhydryl Compounds	126-131	coagulation factor II, thrombin	Homo sapiens	51-59
32416464-15	2020	However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2.	Sulfhydryl Compounds	214-219	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
32416464-15	2020	However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2.	Sulfhydryl Compounds	214-219	kelch like ECH associated protein 1	Homo sapiens	266-271
32416464-15	2020	However, the cells exposed to arsenite are transformed by the continuous nuclear translocation of Nrf2 due to oxidative stress, and the persulfide from dimethylthioarsenics may promote Nrf2 by the combination with thiol groups, especially redox control key protein, Keap1, eventually cause nuclear translocation of sustained Nrf2.	Sulfhydryl Compounds	214-219	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
32523880-13	2020	Extract also significantly improved the effect of AngII on MDA, total thiol content, CAT and SOD in both heart and aorta tissues.	Sulfhydryl Compounds	70-75	angiotensinogen	Rattus norvegicus	50-55
32192339-2	2020	In this report, human hair keratin was extracted with a reduction method and then conjugated with zwitterionic poly(2-methacryloxyethyl phosphatidylcholine, MPC) via thiol chain transfer polymerization(Thiol CTP).	Sulfhydryl Compounds	166-171	solute carrier family 25 member 1	Homo sapiens	208-211
32138909-7	2020	Good linearities of the method for the thiols in human serum were obtained in the range of 0.5-500.0 muM with correlation coefficient (R) greater than 0.9960.	Sulfhydryl Compounds	39-45	latexin	Homo sapiens	101-104
32138909-8	2020	The limit of detection is in the range of 0.07-0.18 muM for the investigated thiols in human serum with relative standard deviations of lower than 13.5% and recoveries ranging from 81.9 to 117.1%.	Sulfhydryl Compounds	77-83	latexin	Homo sapiens	52-55
32279039-14	2020	Overall, these results indicate that frataxin-deficient NRVMs present an altered thiol-redox state which could contribute to the cardiac pathology.	Sulfhydryl Compounds	81-86	frataxin	Rattus norvegicus	37-45
31913846-7	2020	Both Cys thiol masking and dimerization decreased the activity of apoE2 and apoE3 but not apoE4.	Sulfhydryl Compounds	9-14	apolipoprotein E	Homo sapiens	66-71
31913846-7	2020	Both Cys thiol masking and dimerization decreased the activity of apoE2 and apoE3 but not apoE4.	Sulfhydryl Compounds	9-14	apolipoprotein E	Homo sapiens	76-81
31913846-10	2020	Redox-mediated modification of Cys thiols of apoE2 or apoE3, especially disulfide bond formation with apoAII, affects lipid metabolism and consequently may be responsible for the diverse isoform specificity of apoE.	Sulfhydryl Compounds	35-41	apolipoprotein E	Homo sapiens	45-50
31913846-10	2020	Redox-mediated modification of Cys thiols of apoE2 or apoE3, especially disulfide bond formation with apoAII, affects lipid metabolism and consequently may be responsible for the diverse isoform specificity of apoE.	Sulfhydryl Compounds	35-41	apolipoprotein E	Homo sapiens	54-59
31913846-10	2020	Redox-mediated modification of Cys thiols of apoE2 or apoE3, especially disulfide bond formation with apoAII, affects lipid metabolism and consequently may be responsible for the diverse isoform specificity of apoE.	Sulfhydryl Compounds	35-41	apolipoprotein A2	Homo sapiens	102-108
31913846-10	2020	Redox-mediated modification of Cys thiols of apoE2 or apoE3, especially disulfide bond formation with apoAII, affects lipid metabolism and consequently may be responsible for the diverse isoform specificity of apoE.	Sulfhydryl Compounds	35-41	apolipoprotein E	Homo sapiens	45-49
32149496-0	2020	High-Throughput Metal Trap: Sulfhydryl-Functionalized Wood Membrane Stacks for Rapid and Highly Efficient Heavy Metal Ion Removal.	Sulfhydryl Compounds	28-38	TRAP	Homo sapiens	22-26
32300309-7	2020	Furthermore, A1M also inhibited the ROS-induced photoreduction reaction of riboflavin, in a reaction involving the free thiol group in position C34.	Sulfhydryl Compounds	120-125	alpha-1-microglobulin/bikunin precursor	Homo sapiens	13-16
32006712-7	2020	Treatment with CORM-3 and CORM-A1 (all concentrations from 0.1 to 100 muM) decreased thiol group oxidation induced by H2O2/Fe.	Sulfhydryl Compounds	85-90	latexin	Homo sapiens	70-73
32055907-3	2020	In principle, target IL-8 is first treated with the reducing agent tris(2-carboxyethyl)phosphine (TCEP) to yield active thiols and then captured by antibody-functionalized magnetic beads (MBs).	Sulfhydryl Compounds	120-126	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
31724188-8	2020	Cannabidiol inhibits CYP2C19, an isoenzyme responsible for the transformation of clopidogrel to its active thiol metabolite.	Sulfhydryl Compounds	107-112	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	21-28
32175596-8	2020	Furthermore, the addition of an appropriate concentration (5 to 105 micromol/g) of TP/HP-beta-CD inclusion complex decreased the carbonyl content, hydrophobicity, and protein aggregation of MP from lamb tripe, whereas it increased the sulfhydryl content.	Sulfhydryl Compounds	235-245	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	89-96
32061935-0	2020	COA6 facilitates cytochrome c oxidase biogenesis as thiol-reductase for copper metallochaperones in mitochondria.	Sulfhydryl Compounds	52-57	cytochrome c oxidase assembly factor 6	Homo sapiens	0-4
32167516-1	2020	A new N2O-type BODIPY probe (LF-Bop) has been proposed for the selective and sensitive detection of biologically relevant small molecular thiols.	Sulfhydryl Compounds	138-144	BOP	Homo sapiens	32-35
32167516-3	2020	The results show that LF-Bop is able to detect all tested free thiols through a fluorescence turn-on assay.	Sulfhydryl Compounds	63-69	BOP	Homo sapiens	25-28
32235296-0	2020	Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [18F]AlF-Affibody Conjugates.	Sulfhydryl Compounds	0-5	epidermal growth factor receptor	Mus musculus	74-78
32235296-0	2020	Thiol-Reactive PODS-Bearing Bifunctional Chelators for the Development of EGFR-Targeting [18F]AlF-Affibody Conjugates.	Sulfhydryl Compounds	0-5	hepatocyte specific developmental regulation 1	Mus musculus	94-97
32061935-7	2020	We demonstrate that COA6 acts as a thiol-reductase to reduce disulphide bridges of critical cysteine residues in SCO1 and SCO2.	Sulfhydryl Compounds	35-40	cytochrome c oxidase assembly factor 6	Homo sapiens	20-24
32061935-7	2020	We demonstrate that COA6 acts as a thiol-reductase to reduce disulphide bridges of critical cysteine residues in SCO1 and SCO2.	Sulfhydryl Compounds	35-40	synthesis of cytochrome C oxidase 1	Homo sapiens	113-117
32061935-7	2020	We demonstrate that COA6 acts as a thiol-reductase to reduce disulphide bridges of critical cysteine residues in SCO1 and SCO2.	Sulfhydryl Compounds	35-40	synthesis of cytochrome C oxidase 2	Homo sapiens	122-126
32061935-9	2020	Our analyses define COA6 as thiol-reductase, which is essential for CuA biogenesis.	Sulfhydryl Compounds	28-33	cytochrome c oxidase assembly factor 6	Homo sapiens	20-24
32077288-1	2020	An electrochemical method for the C(sp2)-H thioetherification of quinoxalin-2(1H)-ones with primary, secondary, and tertiary thiols is reported.	Sulfhydryl Compounds	116-131	Sp2 transcription factor	Homo sapiens	34-39
32218363-0	2020	The Peroxidatic Thiol of Peroxiredoxin 1 is Nitrosated by Nitrosoglutathione but Coordinates to the Dinitrosyl Iron Complex of Glutathione.	Sulfhydryl Compounds	16-21	peroxiredoxin 1	Homo sapiens	25-40
32245186-5	2020	We report here a novel fluorescence resonance energy transfer based two-photon probe MT-1 for mitochondrial thiols detection.	Sulfhydryl Compounds	108-114	metallothionein 1I, pseudogene	Homo sapiens	85-89
32245186-7	2020	MT-1 shows a fast response, high selectivity, and sensitivity to thiols, as well as a low limit of detection.	Sulfhydryl Compounds	65-71	metallothionein 1I, pseudogene	Homo sapiens	0-4
32245186-8	2020	The two-photon property of MT-1 allows the direct visualization of thiols in live cells and tissues by two-photon microscopy.	Sulfhydryl Compounds	67-73	metallothionein 1I, pseudogene	Homo sapiens	27-31
32245186-9	2020	MT-1 can serve as an effective tool to unravel the diverse biological functions of mitochondrial thiols in living systems.	Sulfhydryl Compounds	97-103	metallothionein 1I, pseudogene	Homo sapiens	0-4
32218335-9	2020	Through an extensive review of aggregate evidence, we discuss herein the functional significance of the thiol-rich protein loricrin from a biochemical, genetic, pathological, metabolic, or immunological aspect with some theoretical and speculative perspectives.	Sulfhydryl Compounds	104-109	loricrin	Mus musculus	123-131
32265897-4	2020	By ICP co-expression analysis, we also identified three IFNgamma-induced genes [(IFNgamma-inducible lysosomal thiol reductase (IFI30), guanylate binding protein1 (GBP1), and guanylate binding protein 4 (GBP4)] as potential novel ICPRGs.	Sulfhydryl Compounds	110-115	interferon gamma	Homo sapiens	56-64
32265897-4	2020	By ICP co-expression analysis, we also identified three IFNgamma-induced genes [(IFNgamma-inducible lysosomal thiol reductase (IFI30), guanylate binding protein1 (GBP1), and guanylate binding protein 4 (GBP4)] as potential novel ICPRGs.	Sulfhydryl Compounds	110-115	IFI30 lysosomal thiol reductase	Homo sapiens	127-132
32152269-4	2020	Competitive adsorption experiments coupled with theoretical calculations reveal that the (100) facet of cadmoselite and (002) facet of greenockite preferentially bind with transferrin via inner-sphere thiol complexation.	Sulfhydryl Compounds	201-206	transferrin	Homo sapiens	172-183
32088959-6	2020	Furthermore, NEP exhibits high selectivity towards VDPs over other protein thiols and low molecular weight thiols.	Sulfhydryl Compounds	75-81	membrane metalloendopeptidase	Homo sapiens	13-16
32088959-6	2020	Furthermore, NEP exhibits high selectivity towards VDPs over other protein thiols and low molecular weight thiols.	Sulfhydryl Compounds	107-113	membrane metalloendopeptidase	Homo sapiens	13-16
31953091-6	2020	Tetradeca-thiolated beta-CD oligomer displayed 8144 +- 317 micromol thiol groups per gram.	Sulfhydryl Compounds	10-15	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	20-27
32197489-3	2020	Protein disulfide isomerase (PDI) reduces disulfide bonds (S-S) to free thiol (-SH) on various proteins.	Sulfhydryl Compounds	72-77	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	0-27
32197489-3	2020	Protein disulfide isomerase (PDI) reduces disulfide bonds (S-S) to free thiol (-SH) on various proteins.	Sulfhydryl Compounds	72-77	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	29-32
32197489-8	2020	PDI siRNA effectively reduced spontaneous seizure activity with decreases in total thiol level on PSD95 and NR2A-PSD95 association.	Sulfhydryl Compounds	83-88	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	0-3
32197489-8	2020	PDI siRNA effectively reduced spontaneous seizure activity with decreases in total thiol level on PSD95 and NR2A-PSD95 association.	Sulfhydryl Compounds	83-88	DLG associated protein 2	Rattus norvegicus	98-103
32197489-8	2020	PDI siRNA effectively reduced spontaneous seizure activity with decreases in total thiol level on PSD95 and NR2A-PSD95 association.	Sulfhydryl Compounds	83-88	DLG associated protein 2	Rattus norvegicus	113-118
32006628-2	2020	Previous studies revealed that sEH activity is inhibited by specific binding of electrophiles to a redox-sensitive thiol (Cys521) adjacent to the catalytic center of the hydrolase.	Sulfhydryl Compounds	115-120	epoxide hydrolase 2, cytoplasmic	Mus musculus	31-34
31791770-8	2020	Additionally, PS-100 particles increase the antioxidant catalase and glutathione S-transferase activities and decrease the total non-protein thiols in FuB-1 cells.	Sulfhydryl Compounds	141-147	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	151-156
31569302-6	2020	In addition, Mia40, the physiological thiol substrate of Erv1, was used as an electron donor for Erv1 in a detailed enzyme kinetic study.	Sulfhydryl Compounds	38-43	Mia40p	Saccharomyces cerevisiae S288C	13-18
31734460-10	2020	Cell adherence to fibronectin coated plates was impaired by urate hydroperoxide, as well as by other oxidants, thiol alkylating agents and PDI inhibitors.	Sulfhydryl Compounds	111-116	fibronectin 1	Homo sapiens	18-29
31734460-12	2020	CONCLUSIONS: Our results demonstrated that urate hydroperoxide affects thiol-oxidation of PDI and other cell surface proteins, impairing cellular adherence.	Sulfhydryl Compounds	71-76	prolyl 4-hydroxylase subunit beta	Homo sapiens	90-93
32057247-1	2020	An efficient, solvent-free synthesis of 2-acylthieno[2,3-b]quinolines is reported from 2-halo-quinolinyl ketones through Cu-TEMPO catalyzed dehydrogenation, sp2-C-H functionalization using elemental sulfur as thiol surrogate (sulfur source) and tetrabutylammonium acetate as an ionic reaction medium.	Sulfhydryl Compounds	209-214	Sp2 transcription factor	Homo sapiens	157-160
31843260-0	2020	The oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 influences intracellular signaling.	Sulfhydryl Compounds	23-38	toll like receptor 2	Homo sapiens	60-64
31843260-0	2020	The oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 influences intracellular signaling.	Sulfhydryl Compounds	23-38	toll like receptor 4	Homo sapiens	69-73
31843260-4	2020	Our central hypothesis is that the oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 are critical for pathogen-initiated intracellular signaling as well in hyperoxia.	Sulfhydryl Compounds	54-69	toll like receptor 2	Homo sapiens	91-95
32087961-8	2020	Mechanistically, thiol reductant DTT treatment or C192S mutation prevented SO2-induced AAT1 sulfenylation and the subsequent inhibition of AAT activity in purified AAT1 protein and primary HUVECs.	Sulfhydryl Compounds	17-22	glutamic-oxaloacetic transaminase 1	Homo sapiens	87-91
31843260-4	2020	Our central hypothesis is that the oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 are critical for pathogen-initiated intracellular signaling as well in hyperoxia.	Sulfhydryl Compounds	54-69	toll like receptor 4	Homo sapiens	100-104
31843260-5	2020	Cysteine thiols of TLR4 and its co-receptor MD2 have been shown to aid binding between the two molecules and also bacterial LPS binding to the receptor complex.	Sulfhydryl Compounds	0-15	toll like receptor 4	Homo sapiens	19-23
31843260-5	2020	Cysteine thiols of TLR4 and its co-receptor MD2 have been shown to aid binding between the two molecules and also bacterial LPS binding to the receptor complex.	Sulfhydryl Compounds	0-15	lymphocyte antigen 96	Homo sapiens	44-47
31843260-6	2020	We extend these findings by demonstrating the oxidation of free thiols on the ectodomain of hTLR4, after exposure to LPS or hyperoxia suggesting that the cysteines on the ectodomain of TLR4 could form intra- or intermolecular disulfide bonds.	Sulfhydryl Compounds	64-70	toll like receptor 4	Homo sapiens	92-97
31843260-6	2020	We extend these findings by demonstrating the oxidation of free thiols on the ectodomain of hTLR4, after exposure to LPS or hyperoxia suggesting that the cysteines on the ectodomain of TLR4 could form intra- or intermolecular disulfide bonds.	Sulfhydryl Compounds	64-70	toll like receptor 4	Homo sapiens	93-97
31843260-7	2020	We also demonstrated blockade of intracellular signaling from TLR4 and TLR2 by thiol-modifying compounds which suggest a novel therapeutic intervention for sepsis, hyperoxia-induced cell injury and yeast infection.	Sulfhydryl Compounds	79-84	toll like receptor 4	Homo sapiens	62-66
31843260-7	2020	We also demonstrated blockade of intracellular signaling from TLR4 and TLR2 by thiol-modifying compounds which suggest a novel therapeutic intervention for sepsis, hyperoxia-induced cell injury and yeast infection.	Sulfhydryl Compounds	79-84	toll like receptor 2	Homo sapiens	71-75
32051359-3	2020	Contact angle values and the attenuated total reflectance Fourier transform infrared (ATR/FT-IR) spectra of the QCM sensors after immersion into an ethanol solution of thiol derivatives clearly showed that self-assembled monolayers of the derivatives were formed on the QCM sensors.	Sulfhydryl Compounds	168-173	ATR serine/threonine kinase	Homo sapiens	86-89
31977118-1	2020	With a combination of atom transfer radical polymerization (ATRP), quasi-living Grignard metathesis method, and thiol-ene click reaction, an amphiphilic star-like rod-coil diblock copolymer poly(acrylic acid)-block-poly(3-hexylthiophene) comprising 21-arm inner coil-like PAA blocks and outer rod-like conjugated polymer poly(3-hexylthiophene) (P3HT) blocks with well-defined molecular structures and narrow molecular weight distribution is synthesized.	Sulfhydryl Compounds	112-117	steroidogenic acute regulatory protein	Homo sapiens	153-157
30601070-3	2020	Angiopep-2 was functionalized to nanoparticles via a maleimide-thiol covalent binding reaction to obtain ANG-Rg3-NP.	Sulfhydryl Compounds	63-68	angiogenin	Homo sapiens	105-108
31945496-0	2020	Thiol antioxidants sensitize malabaricone C induced cancer cell death via reprogramming redox sensitive p53 and NF-kappaB proteins in vitro and in vivo.	Sulfhydryl Compounds	0-5	tumor protein p53	Homo sapiens	104-107
31945496-0	2020	Thiol antioxidants sensitize malabaricone C induced cancer cell death via reprogramming redox sensitive p53 and NF-kappaB proteins in vitro and in vivo.	Sulfhydryl Compounds	0-5	nuclear factor kappa B subunit 1	Homo sapiens	112-121
31945496-8	2020	Secondly, thiol antioxidants cause rapid glutathionylation of transcription factors [p53, p65 (NF-kappaB) etc.	Sulfhydryl Compounds	10-15	tumor protein p53	Homo sapiens	85-88
31945496-8	2020	Secondly, thiol antioxidants cause rapid glutathionylation of transcription factors [p53, p65 (NF-kappaB) etc.	Sulfhydryl Compounds	10-15	RELA proto-oncogene, NF-kB subunit	Homo sapiens	90-93
31945496-8	2020	Secondly, thiol antioxidants cause rapid glutathionylation of transcription factors [p53, p65 (NF-kappaB) etc.	Sulfhydryl Compounds	10-15	nuclear factor kappa B subunit 1	Homo sapiens	95-104
31977118-3	2020	Subsequently, 21-arm star-like coil polymers PtBA-SCOCH3 react with rod-like vinyl-functionalized P3HT to yield functional star-like rod-coil diblock copolymers PtBA-b-P3HT via thiol-ene click reaction, followed by selective hydrolysis of inner PtBA block into PAA block.	Sulfhydryl Compounds	177-182	steroidogenic acute regulatory protein	Homo sapiens	21-25
31977118-3	2020	Subsequently, 21-arm star-like coil polymers PtBA-SCOCH3 react with rod-like vinyl-functionalized P3HT to yield functional star-like rod-coil diblock copolymers PtBA-b-P3HT via thiol-ene click reaction, followed by selective hydrolysis of inner PtBA block into PAA block.	Sulfhydryl Compounds	177-182	steroidogenic acute regulatory protein	Homo sapiens	123-127
31977118-4	2020	The present synthetic approach enables the construction of well-defined star-like conformation with few structural limitations in a facile and highly efficient manner due to the robust and orthogonal nature of the thiol-ene click reaction.	Sulfhydryl Compounds	214-219	steroidogenic acute regulatory protein	Homo sapiens	72-76
31944110-1	2020	One tactic for cysteine protease inhibition is to form a covalent bond between an electrophilic atom of the inhibitor and the thiol of the catalytic cysteine.	Sulfhydryl Compounds	126-131	cathepsin B	Homo sapiens	15-32
31985207-1	2020	The purpose of the study was to develop a per-6-thiolated alpha-cyclodextrin (alpha-CD) by substituting all primary hydroxyl groups of alpha-CD with thiol groups and to assess its solubility-improving and permeation-enhancing properties for a BCS Class IV drug in vitro as well as in vivo.	Sulfhydryl Compounds	48-53	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-86
31985207-1	2020	The purpose of the study was to develop a per-6-thiolated alpha-cyclodextrin (alpha-CD) by substituting all primary hydroxyl groups of alpha-CD with thiol groups and to assess its solubility-improving and permeation-enhancing properties for a BCS Class IV drug in vitro as well as in vivo.	Sulfhydryl Compounds	48-53	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-143
31985207-7	2020	The per-6-thiolated alpha-CD oligomer displayed 4244 +- 402 mumol/g thiol groups.	Sulfhydryl Compounds	10-15	ACD, shelterin complex subunit and telomerase recruitment factor	Rattus norvegicus	20-28
32087961-8	2020	Mechanistically, thiol reductant DTT treatment or C192S mutation prevented SO2-induced AAT1 sulfenylation and the subsequent inhibition of AAT activity in purified AAT1 protein and primary HUVECs.	Sulfhydryl Compounds	17-22	serpin family A member 1	Homo sapiens	87-90
32087961-8	2020	Mechanistically, thiol reductant DTT treatment or C192S mutation prevented SO2-induced AAT1 sulfenylation and the subsequent inhibition of AAT activity in purified AAT1 protein and primary HUVECs.	Sulfhydryl Compounds	17-22	glutamic-oxaloacetic transaminase 1	Homo sapiens	164-168
32076070-3	2020	We have previously shown that beta2AR agonism generates intracellular ROS, an effect that is required for receptor function, and which post-translationally oxidizes beta2AR cysteine thiols to Cys-S-sulfenic acids (Cys-S-OH).	Sulfhydryl Compounds	173-188	adenosine A2a receptor	Homo sapiens	30-37
31630859-5	2020	Ball milling method improved the properties of BMS-biochar, namely, more efficient SH load, a larger surface area, more functional groups, more negatively charged surface, which resulted in higher removal efficiency of Hg2+ and CH3Hg+ (320.1 mg/g for Hg2+ and 104.9 mg/g for CH3Hg+) compared to the pristine biochar (105.7 mg/g for Hg2+ and 8.21 mg/g for CH3Hg+) and thiol-modified biochar through chemical impregnation (CIS-biochar) (175.6 mg/g for Hg2+ and 58.0 mg/g for CH3Hg+).	Sulfhydryl Compounds	367-372	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	219-222
32076070-3	2020	We have previously shown that beta2AR agonism generates intracellular ROS, an effect that is required for receptor function, and which post-translationally oxidizes beta2AR cysteine thiols to Cys-S-sulfenic acids (Cys-S-OH).	Sulfhydryl Compounds	173-188	adenosine A2a receptor	Homo sapiens	165-172
31630859-0	2020	Thiol-modified biochar synthesized by a facile ball-milling method for enhanced sorption of inorganic Hg2+ and organic CH3Hg.	Sulfhydryl Compounds	0-5	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	102-105
32085555-7	2020	This fact indicates the interactions between TGA thiol group and dangling bonds of Ag 2 S nanocrystals.	Sulfhydryl Compounds	49-54	angiotensin II receptor type 1	Homo sapiens	83-89
32085555-11	2020	This feature is caused by the change in the symmetry of TGA molecules due to passivation of Ag 2 S quantum dots.For Ag 2 S/TGA QDs with recombination luminescence, the insignificant high-frequency shift of 7-10 cm - 1 for nu a s (COO - ) at 1567 cm - 1 and low-frequency shift of 3-5 cm - 1 for nu s (COO - ) at 1388 cm - 1 , probably caused by the interaction of thiol with Ag 2 S surface is observed.	Sulfhydryl Compounds	364-369	angiotensin II receptor type 1	Homo sapiens	116-122
32085555-11	2020	This feature is caused by the change in the symmetry of TGA molecules due to passivation of Ag 2 S quantum dots.For Ag 2 S/TGA QDs with recombination luminescence, the insignificant high-frequency shift of 7-10 cm - 1 for nu a s (COO - ) at 1567 cm - 1 and low-frequency shift of 3-5 cm - 1 for nu s (COO - ) at 1388 cm - 1 , probably caused by the interaction of thiol with Ag 2 S surface is observed.	Sulfhydryl Compounds	364-369	angiotensin II receptor type 1	Homo sapiens	116-122
31898870-3	2020	By employing a DBP tagged with a certain FG, such as thiol, biotin, and carboxyl acid, it is possible to introduce any FG with a controlled density on DNA-wrapped CNTs.	Sulfhydryl Compounds	53-58	D-box binding PAR bZIP transcription factor	Homo sapiens	15-18
31814373-7	2020	Conclusion: The results showed that thiol/disulfide homeostasis in patients with autoimmune gastritis caused an increase in ischemia modified albumin and disulfide whereas a decrease in thiols.	Sulfhydryl Compounds	36-41	albumin	Homo sapiens	142-149
31942788-5	2020	The calculations of DFT, the experimental results and the characterization analyses suggest that the binding mechanisms are the chelation, ion exchange and electrostatic interactions between hydroxyl/amino/sulfhydryl groups of UiO-66-ATA(Zr) and Pb(II).	Sulfhydryl Compounds	206-216	submaxillary gland androgen regulated protein 3B	Homo sapiens	246-252
32033303-6	2020	The LODs for alpha-lipoic acid and low-molecular-mass thiols were 0.08 and 0.12 nmol mL-1, respectively, while LOQs were 0.12 and 0.16 nmol mL-1, respectively.	Sulfhydryl Compounds	54-60	L1 cell adhesion molecule	Mus musculus	85-89
31518425-2	2020	In the presence of oxidative and electrophilic insults, the thiols of cysteine residues in KEAP1 are modified, and subsequently stabilized NRF2 activates its target genes that are involved in detoxification and cytoprotection.	Sulfhydryl Compounds	60-66	kelch like ECH associated protein 1	Homo sapiens	91-96
31518425-2	2020	In the presence of oxidative and electrophilic insults, the thiols of cysteine residues in KEAP1 are modified, and subsequently stabilized NRF2 activates its target genes that are involved in detoxification and cytoprotection.	Sulfhydryl Compounds	60-66	NFE2 like bZIP transcription factor 2	Homo sapiens	139-143
31703989-7	2020	Fourier transform infrared spectral analysis revealed that the stretching vibration at 2560 cm-1 responsible for S-H bond of thiol group disappeared suggesting the conjugation of 2-mercaptoethanol with Ag2S nanoparticles.	Sulfhydryl Compounds	125-130	angiotensin II receptor type 1	Homo sapiens	202-206
32033229-5	2020	In addition, R-As2+-compounds have even higher affinity to selenol groups, e.g., in thioredoxin reductase that also possesses a thiol group vicinal to the selenol.	Sulfhydryl Compounds	128-133	peroxiredoxin 5	Homo sapiens	84-105
31863908-4	2020	Here, we show that a thiol group of Cys111 in SOD1 is oxidized to a sulfenic acid with hydrogen peroxide and reveal that further dissociation of the bound metal ions from the oxidized SOD1 allows another free Cys residue (Cys6) to nucleophilically attack the sulfenylated Cys111.	Sulfhydryl Compounds	21-26	superoxide dismutase 1	Homo sapiens	46-50
31863908-4	2020	Here, we show that a thiol group of Cys111 in SOD1 is oxidized to a sulfenic acid with hydrogen peroxide and reveal that further dissociation of the bound metal ions from the oxidized SOD1 allows another free Cys residue (Cys6) to nucleophilically attack the sulfenylated Cys111.	Sulfhydryl Compounds	21-26	superoxide dismutase 1	Homo sapiens	184-188
31838203-4	2020	For successful delivery of siKRAS, tGC/psi-nanoparticle formulation of polymerized siRNA and thiol-modified glycol chitosan nanoparticle-was used for KRAS specific inhibition in vitro and in vivo.	Sulfhydryl Compounds	93-98	KRAS proto-oncogene, GTPase	Homo sapiens	29-33
30522366-6	2020	No significant difference was found between the patients with early onset and late onset preeclampsia regarding TXNDC5 levels and thiol/disulfide homeostasis (p > .05).Conclusion: Serum TXNDC5 levels were significantly higher in patients with early-onset and late-onset preeclampsia.	Sulfhydryl Compounds	130-135	thioredoxin domain containing 5	Homo sapiens	186-192
31774080-3	2020	In the present study, the dynamics of the structural change of hGal-1 by the formation of disulfide bonds were investigated by time-resolved FTIR spectroscopy combined with a modification in which its thiol groups (-SH) were replaced with S-nitrosylated groups (SNO).	Sulfhydryl Compounds	201-206	galectin 1	Homo sapiens	63-69
31816776-0	2020	Utilizing the thiol chemistry of biomolecules for the rapid determination of anti-TNF-alpha drug in blood.	Sulfhydryl Compounds	14-19	tumor necrosis factor	Homo sapiens	82-91
31706236-4	2020	What"s more, significantly elevated thiol groups (PC2 and PC3) in CX4 under Cd stress might contribute to the high Cd accumulation in roots and the root-to-shoot translocation of Cd-PC complex.	Sulfhydryl Compounds	36-41	chromobox 4	Homo sapiens	50-53
31706236-4	2020	What"s more, significantly elevated thiol groups (PC2 and PC3) in CX4 under Cd stress might contribute to the high Cd accumulation in roots and the root-to-shoot translocation of Cd-PC complex.	Sulfhydryl Compounds	36-41	chromobox 8	Homo sapiens	58-61
31963801-7	2020	The analysis based on the nucleotide sequences of the ESBL resistance genes showed that all cefotaximase-Munichs (CTX-Ms) were CTX-M-15 and that all sulfhydryl variables (SHVs) were SHV-11: 41.67% CTX-M-15-producing E. coli, 16.67% CTX-M-15+SHV-11-producing E. coli, 8.33% CTX-M-15-producing K. pneumoniae, 25% CTX-M-15+SHV-11-producing K. pneumoniae, and 8.33% CTX-M-15-produced E. cloacae.	Sulfhydryl Compounds	149-159	EsbL	Escherichia coli	54-58
31538772-8	2020	Thiol nucleophiles decreased the extent of covalent binding to the model protein bovine serum albumin, while amine and alcohol nucleophiles had no effect, suggesting reactivity with cysteine of proteins.	Sulfhydryl Compounds	0-5	albumin	Homo sapiens	88-101
31963721-10	2020	As a consequence, the free thiol of monomeric Tff1 could have a protective scavenger function, e.g., for reactive oxygen/nitrogen species.	Sulfhydryl Compounds	27-32	trefoil factor 1	Mus musculus	46-50
32016114-4	2020	By comparison with the control group, the EST group had significantly higher levels of serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), creatine kinase MB (CK-MB), myoglobin, cardiac TBARS, nitric oxide (NO), total thiol and hydrogen peroxide, cardiac damage, and expression of P53 and TNFalpha.	Sulfhydryl Compounds	231-236	mitogen-activated protein kinase kinase kinase 8	Mus musculus	42-45
31951630-7	2020	Here we show that CNP initiate a mitochondrial increase of ROS levels accompanied by an increase in mitochondrial thiol oxidation.	Sulfhydryl Compounds	114-119	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	18-21
31941973-3	2020	We detected the formation of acrylamide adducts with thiol groups from both metabolites and protein residues, leading to a quasi-complete depletion of glutathione and to the inactivation of different components of the thioredoxin system.	Sulfhydryl Compounds	53-58	thioredoxin	Homo sapiens	218-229
32010088-1	2019	As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target.	Sulfhydryl Compounds	5-10	AT695_RS13830	Staphylococcus aureus	29-50
32010088-1	2019	As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target.	Sulfhydryl Compounds	5-10	AT695_RS13830	Staphylococcus aureus	52-56
32496983-6	2020	Nrf2, which activates the antioxidant response element (ARE) leading to up-regulation of GPx, thiol metabolism-associated detoxifying enzymes (GSTs) and stress-response genes (HO-1) are all downregulated in animal models and patients with asthma and COPD.	Sulfhydryl Compounds	94-99	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31711899-4	2020	In this work, RGDS functionalized and enzymatically degradable poly(ethylene glycol) (PEG) microgels were annealed into MAP hydrogels via thiol-ene click chemistry and photopolymerization.	Sulfhydryl Compounds	138-143	ral guanine nucleotide dissociation stimulator	Homo sapiens	14-18
31906414-4	2020	During the initiation of cell death, numerous vacuoles formed from ER cisterns in the cytoplasm, and cell death was partially suppressed by the inhibitors of protein synthesis and folding, the IP3 receptor inhibitor as well as by thiols.	Sulfhydryl Compounds	230-236	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	193-205
31669698-4	2020	We developed four synthetic approaches to generate RBC-Staphylococcal protein A (RBC-SpA) complexes: amino group targeting through N-hydrosuccinidyl ester-functionalized homobifunctional poly(ethylene glycol) (NHS-PEG-NHS), direct thiol group targeting using heterobifunctional NHS-PEG-maleimide (NHS-PEG-MAL), converted thiol targeting using heterobifunctional NHS-PEG-MAL, and click chemistry using a heterobifunctional NHS-PEG-azido (NHS-PEG-N3) and NHS-PEG-alkyne (NHS-PEG-alk).	Sulfhydryl Compounds	231-236	surfactant protein A1	Homo sapiens	85-88
31669698-4	2020	We developed four synthetic approaches to generate RBC-Staphylococcal protein A (RBC-SpA) complexes: amino group targeting through N-hydrosuccinidyl ester-functionalized homobifunctional poly(ethylene glycol) (NHS-PEG-NHS), direct thiol group targeting using heterobifunctional NHS-PEG-maleimide (NHS-PEG-MAL), converted thiol targeting using heterobifunctional NHS-PEG-MAL, and click chemistry using a heterobifunctional NHS-PEG-azido (NHS-PEG-N3) and NHS-PEG-alkyne (NHS-PEG-alk).	Sulfhydryl Compounds	321-326	surfactant protein A1	Homo sapiens	85-88
31589114-4	2020	Thioredoxin and glutathione systems are the two major thiol-dependent systems not only provide antioxidant capacity but also participate in various biological events in bacteria, such as DNA synthesis and protein folding.	Sulfhydryl Compounds	54-59	thioredoxin	Homo sapiens	0-11
31889463-1	2020	A previous study showed that introducing an Arabidopsis thaliana thiol/disulfide-modulating protein, Low Quantum Yield of Photosystem II 1 (LQY1), into the cyanobacterium Synechocystis sp.	Sulfhydryl Compounds	65-70	DnaJ/Hsp40 cysteine-rich domain superfamily protein	Arabidopsis thaliana	140-144
31557719-2	2020	SELENBP1 is associated with cellular redox and thiol homeostasis in several respects, including its established role as a methanethiol oxidase that is involved in degradation of methanethiol, a methionine catabolite, generating hydrogen sulfide (H2S) and hydrogen peroxide (H2O2).	Sulfhydryl Compounds	47-52	selenium binding protein 1	Homo sapiens	0-8
31909639-8	2020	Subsequent addition of dithiothreitol caused recovery of caspase-3 activity indicating involvement of the oxidation of the Cys-thiol group.	Sulfhydryl Compounds	123-132	caspase 3	Mus musculus	57-66
31521661-0	2020	A review on the druggability of a thiol-based enzymatic antioxidant thioredoxin reductase for treating filariasis and other parasitic infections.	Sulfhydryl Compounds	34-39	peroxiredoxin 5	Homo sapiens	68-89
31521661-5	2020	The thiol-based antioxidant enzymes (glutathione reductase and thioredoxin reductase) have dragged much attention of the researchers to date.	Sulfhydryl Compounds	4-9	glutathione-disulfide reductase	Homo sapiens	37-58
31521661-5	2020	The thiol-based antioxidant enzymes (glutathione reductase and thioredoxin reductase) have dragged much attention of the researchers to date.	Sulfhydryl Compounds	4-9	peroxiredoxin 5	Homo sapiens	63-84
31521661-6	2020	In this regard, among the thiol-based antioxidants, particularly the Thioredoxin reductase (TrxR), is known to be present in a number of parasitic organisms have pulled the researchers.	Sulfhydryl Compounds	26-31	peroxiredoxin 5	Homo sapiens	69-90
31521661-6	2020	In this regard, among the thiol-based antioxidants, particularly the Thioredoxin reductase (TrxR), is known to be present in a number of parasitic organisms have pulled the researchers.	Sulfhydryl Compounds	26-31	peroxiredoxin 5	Homo sapiens	92-96
30789800-6	2020	All doses of Vit C increased thyroxine, protein and albumin and thiol content in in renal and liver tissues while, decreased AST, ALT and ALK-P concentration and MDA in liver and renal tissues compared to PTU group (P<0.05-P<0.001).	Sulfhydryl Compounds	64-69	vitrin	Rattus norvegicus	13-16
32607985-3	2020	Subsequent regeneration of the low-molecular weight antioxidants by NAD(P)H and thioredoxin/thiol-dependent pathways relaxes the electron pressure in the photosynthetic electron transport chain.	Sulfhydryl Compounds	92-97	thioredoxin	Homo sapiens	80-91
31738662-10	2020	Essentially, the moles of PrC-210 thiol within a single 0.5 MTD PrC-210 dose suppressed the moles of ROS generated by 40% of the 4 Gy X-ray dose administered to p53-/- pups, and in doing so, eliminated the lifetime leukemia/lymphoma risk normally residing "downstream" of that 40% of the 4 Gy dose.	Sulfhydryl Compounds	34-39	transformation related protein 53, pseudogene	Mus musculus	161-164
31546169-4	2020	A combination of biochemical, biophysical, crystallographic and cell biology approaches revealed a new and, to our knowledge, unique mode of Aurora A inhibition by CoA, involving selective binding of the ADP moiety of CoA to the ATP binding pocket and covalent modification of Cys290 in the activation loop by the thiol group of the pantetheine tail.	Sulfhydryl Compounds	314-319	aurora kinase A	Homo sapiens	141-149
31845089-1	2019	A dual column packed with a magnetic metal-organic framework composite (MFC) and mercapto-functionalized MFC nanoparticles (MFC-SH) in microfluidic chip channels is described for array chip-based magnetic solid phase microextraction of arsenic species including arsenite [As(III)], arsenate [As(V)], monomethylarsonous acid (MMA) and dimethylarsinic acid (DMA) in SCC-7 cells.	Sulfhydryl Compounds	81-89	colon tumor susceptibility 7	Mus musculus	364-369
31890941-2	2019	Thioredoxin (Trx) family proteins efficiently catalyze thiol-disulfide exchange reactions and the proteins are widely recognized for their importance in the operation of thiol switches.	Sulfhydryl Compounds	55-70	thioredoxin	Homo sapiens	0-11
31890941-2	2019	Thioredoxin (Trx) family proteins efficiently catalyze thiol-disulfide exchange reactions and the proteins are widely recognized for their importance in the operation of thiol switches.	Sulfhydryl Compounds	55-70	thioredoxin	Homo sapiens	13-16
31890941-2	2019	Thioredoxin (Trx) family proteins efficiently catalyze thiol-disulfide exchange reactions and the proteins are widely recognized for their importance in the operation of thiol switches.	Sulfhydryl Compounds	55-60	thioredoxin	Homo sapiens	0-11
31890941-2	2019	Thioredoxin (Trx) family proteins efficiently catalyze thiol-disulfide exchange reactions and the proteins are widely recognized for their importance in the operation of thiol switches.	Sulfhydryl Compounds	55-60	thioredoxin	Homo sapiens	13-16
31845089-9	2019	Graphical abstractSchematic representation of magnetic metal-organic framework composite (MFC) and mercapto-functionalized MFC nanoparticles (MFC-SH) packed dual-column, squamous carcinoma cells (SCC-7), online chip-based array MSPME-ICPMS system.	Sulfhydryl Compounds	99-107	colon tumor susceptibility 7	Mus musculus	196-201
31449969-8	2019	CRISPR-edited MUT and PCCA HEK293 cells recapitulate primary defects of MMA and PA and have upregulation of transcripts associated with serine and thiol metabolism including PSAT1.	Sulfhydryl Compounds	147-152	propionyl-CoA carboxylase subunit alpha	Homo sapiens	22-26
31921758-2	2019	This study introduced tert dodecyl mercaptan (TDM) together with NaOl as a mixed collector to improve selectivity in diaspore flotation.	Sulfhydryl Compounds	46-49	telomerase reverse transcriptase	Homo sapiens	22-26
31585568-4	2019	Taking insulin as example of biomarker in human serum, we developed sulfhydryl human insulin aptamer functionalized magnetic metal organic framework (denoted as Mag MOF@Au@HIA) through the post-synthetic modification of MIL-101(Cr)-NH2 for testing the applicability of the established method.	Sulfhydryl Compounds	68-78	insulin	Homo sapiens	85-92
31651920-1	2019	We report the design of a mucin hydrogel created using a thiol-based cross-linking strategy.	Sulfhydryl Compounds	57-62	LOC100508689	Homo sapiens	26-31
31662433-5	2019	Although ATIII has N-glycans and a hydrophobic core, we found that its quality control depended solely on free thiol content.	Sulfhydryl Compounds	111-116	serpin family C member 1	Homo sapiens	9-14
31662433-7	2019	ATIII variants with free thiols were retained in the ER but not degraded.	Sulfhydryl Compounds	25-31	serpin family C member 1	Homo sapiens	0-5
32280641-9	2019	Abeta induced a significant decrease in the total thiol content of hippocampus, and pelargonidin restored the hippocampal antioxidant capacity.	Sulfhydryl Compounds	50-55	amyloid beta precursor protein	Rattus norvegicus	0-5
31585568-4	2019	Taking insulin as example of biomarker in human serum, we developed sulfhydryl human insulin aptamer functionalized magnetic metal organic framework (denoted as Mag MOF@Au@HIA) through the post-synthetic modification of MIL-101(Cr)-NH2 for testing the applicability of the established method.	Sulfhydryl Compounds	68-78	insulin	Homo sapiens	7-14
31653696-3	2019	It has also been suggested that DJ-1 serves as a deglycase that catalyzes hydrolysis of hemithioacetals and hemiaminals formed by reactions of MGO with the thiol and amino groups of proteins.	Sulfhydryl Compounds	156-161	Parkinsonism associated deglycase	Homo sapiens	32-36
31449969-8	2019	CRISPR-edited MUT and PCCA HEK293 cells recapitulate primary defects of MMA and PA and have upregulation of transcripts associated with serine and thiol metabolism including PSAT1.	Sulfhydryl Compounds	147-152	phosphoserine aminotransferase 1	Homo sapiens	174-179
31801208-2	2019	Once in cells, MeHg actively binds thiols and selenols, interfering with the activity of redox enzymes such as thioredoxin (Trx) and the selenoenzyme thioredoxin reductase (TrxR) which integrate the thioredoxin system.	Sulfhydryl Compounds	35-41	peroxiredoxin 5	Homo sapiens	150-171
31393047-2	2019	Additionally, ADAMTS13 is thought to regulate lateral association of VWF multimers to form fibrillar structures through its free thiols.	Sulfhydryl Compounds	129-135	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	14-22
31393047-2	2019	Additionally, ADAMTS13 is thought to regulate lateral association of VWF multimers to form fibrillar structures through its free thiols.	Sulfhydryl Compounds	129-135	von Willebrand factor	Homo sapiens	69-72
31393047-3	2019	OBJECTIVE: The purpose of the present study is to obtain direct evidence for ADAMTS13 to engage in thiol/disulfide exchange reactions.	Sulfhydryl Compounds	99-104	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	77-85
31393047-9	2019	Several partially reduced free thiols are identified in ADAMTS13, with cysteines 1254 and 1275 being the most prominent, although a point mutation (C1275S) in ADAMTS13 does not alter its ability to form covalent linkages with VWF.	Sulfhydryl Compounds	31-37	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	56-64
31393047-12	2019	CONCLUSIONS: Our results suggest that a dynamic network of free thiols in ADAMTS13 undergoing intra- and inter-molecular redox reactions may add another layer of regulation to VWF function under various conditions.	Sulfhydryl Compounds	64-70	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	74-82
31393047-12	2019	CONCLUSIONS: Our results suggest that a dynamic network of free thiols in ADAMTS13 undergoing intra- and inter-molecular redox reactions may add another layer of regulation to VWF function under various conditions.	Sulfhydryl Compounds	64-70	von Willebrand factor	Homo sapiens	176-179
31680614-4	2019	The recombinant Grx was able to efficiently catalyze the thiol-disulfide oxidoreduction of insulin in the presence of DTT as an election donor.	Sulfhydryl Compounds	57-72	glutaredoxin	Homo sapiens	16-19
31680614-4	2019	The recombinant Grx was able to efficiently catalyze the thiol-disulfide oxidoreduction of insulin in the presence of DTT as an election donor.	Sulfhydryl Compounds	57-72	insulin	Homo sapiens	91-98
31448653-10	2019	In particular, the PTM of beta2GPI via thiol-exchange reactions is a highly specific phenomenon that makes the protein more antigenic.	Sulfhydryl Compounds	39-44	apolipoprotein H	Homo sapiens	26-34
31801293-7	2019	For the first time, we hypothesize that the free thiol of monomeric xP1-and probably also its mammalian ortholog TFF1-could have a protective scavenger function, e.g., for reactive oxygen/nitrogen species.	Sulfhydryl Compounds	49-54	XPA, DNA damage recognition and repair factor	Homo sapiens	68-71
31801293-7	2019	For the first time, we hypothesize that the free thiol of monomeric xP1-and probably also its mammalian ortholog TFF1-could have a protective scavenger function, e.g., for reactive oxygen/nitrogen species.	Sulfhydryl Compounds	49-54	trefoil factor 1	Homo sapiens	113-117
31801208-2	2019	Once in cells, MeHg actively binds thiols and selenols, interfering with the activity of redox enzymes such as thioredoxin (Trx) and the selenoenzyme thioredoxin reductase (TrxR) which integrate the thioredoxin system.	Sulfhydryl Compounds	35-41	peroxiredoxin 5	Homo sapiens	173-177
31776360-4	2019	The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2alpha2 (JNK2alpha2).	Sulfhydryl Compounds	120-125	peroxiredoxin 1	Mus musculus	101-116
31776360-4	2019	The mechanism involves signaling by mitochondria-generated H2O2 (mH2O2) acting via the redox sensor, peroxiredoxin-1, a thiol peroxidase with high reactivity towards H2O2 that activates c-Jun N-terminal kinase-2alpha2 (JNK2alpha2).	Sulfhydryl Compounds	120-125	jun proto-oncogene	Mus musculus	186-191
31772124-0	2019	Thiol-based direct threat sensing by the stress-activated protein kinase Hog1.	Sulfhydryl Compounds	0-5	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	73-77
31394422-2	2019	A three-dimensional network structure (...Au-SNH2 Mn+ H2NS-Au...) was formed after the Mn+ (Pb2+, Cd2+, Zn2+ and Ag+) coordinated the gold nanoparticles through the amino group in the thiol ligand, which promoted aurophilicity (...Au...Au...)	Sulfhydryl Compounds	184-189	CD2 molecule	Homo sapiens	98-101
31760490-11	2019	Hydrolysis of the cytoprotective adjuvant amifostine (a phosphothioester) by ALP leads to a thiol that causes the decomposition of the MnO2 nanosheets.	Sulfhydryl Compounds	92-97	alkaline phosphatase, placental	Homo sapiens	77-80
31660558-2	2019	Surface chirality that shortens the surface residence time of Abeta, for example, R-cysteine modification with carboxylic, secondary amine and thiol groups surrounding the chiral center, can retard Abeta oligomerization and fibrillation.	Sulfhydryl Compounds	143-148	amyloid beta precursor protein	Homo sapiens	62-67
31724952-3	2019	Here we measured the access of thiol-reactive ions across the selectivity filters in rodent TRPV1-3 channels.	Sulfhydryl Compounds	31-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-99
31660558-2	2019	Surface chirality that shortens the surface residence time of Abeta, for example, R-cysteine modification with carboxylic, secondary amine and thiol groups surrounding the chiral center, can retard Abeta oligomerization and fibrillation.	Sulfhydryl Compounds	143-148	amyloid beta precursor protein	Homo sapiens	198-203
31596284-0	2019	Supramolecular chirality of coordination polymers of Ag+ with a chiral thiol ligand that bears a beta-turn structure.	Sulfhydryl Compounds	71-76	amyloid beta precursor protein	Homo sapiens	95-101
31596284-1	2019	We report coordination polymers forming from Ag+ and a chiral thiol ligand that bears a beta-turn structure, exhibiting supramolecular chirality showing both the majority rules effect (MRE) and the racemate rules effect (RRE).	Sulfhydryl Compounds	62-67	amyloid beta precursor protein	Homo sapiens	86-92
31760917-2	2019	The main problem of selective GAPDH inhibition is a highly conserved nature of the enzyme active site and, especially, Cys150 environment important for the catalytic action of cysteine sulfhydryl group.	Sulfhydryl Compounds	176-195	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	30-35
31662505-0	2019	Increased Expression of Ecto-NOX Disulfide-thiol Exchanger 1 (ENOX1) in Diabetic Mice Retina and its Involvement in Diabetic Retinopathy Development.	Sulfhydryl Compounds	43-48	tripartite motif-containing 33	Mus musculus	24-28
31662505-0	2019	Increased Expression of Ecto-NOX Disulfide-thiol Exchanger 1 (ENOX1) in Diabetic Mice Retina and its Involvement in Diabetic Retinopathy Development.	Sulfhydryl Compounds	43-48	ecto-NOX disulfide-thiol exchanger 1	Mus musculus	62-67
31662505-2	2019	Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) is a member of the ecto-NOX family involved in the plasma membrane electron transport pathway.	Sulfhydryl Compounds	19-24	tripartite motif-containing 33	Mus musculus	0-4
31662505-2	2019	Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) is a member of the ecto-NOX family involved in the plasma membrane electron transport pathway.	Sulfhydryl Compounds	19-24	ecto-NOX disulfide-thiol exchanger 1	Mus musculus	38-43
31662505-2	2019	Ecto-NOX disulfide-thiol exchanger 1 (ENOX1) is a member of the ecto-NOX family involved in the plasma membrane electron transport pathway.	Sulfhydryl Compounds	19-24	tripartite motif-containing 33	Mus musculus	64-68
31318380-7	2019	These results suggest that mitochondrial thiol redox systems are responsible for maintaining AOX in its reduced form rather than regulating its activity in vivo.	Sulfhydryl Compounds	41-46	alternative oxidase 2	Arabidopsis thaliana	93-96
31395444-8	2019	The level of total thiols was lower in the Ben-Sed group than in the Sta-Tr group.	Sulfhydryl Compounds	19-25	autosomal striping	Mus musculus	69-72
31395444-10	2019	The concentration of non-protein thiols in the muscle was higher in the Ben-Sed group than in the Ben-Tr group, whereas in the heart, concentration of non-protein thiols of Sta-Tr group was lower than that of Sta-Sed group.	Sulfhydryl Compounds	163-169	autosomal striping	Mus musculus	173-176
31219655-5	2019	A thiol-derivatized hyaluronan hydrogel cross-linked with polyethyleneglycol diacrylate (PEGDA) was used to topically deliver a cyclized epiviosamine: cP12 and a cyclized engineered variant of cP12 termed cNP8 to porcine, full-thickness, excisional wounds.	Sulfhydryl Compounds	2-7	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	151-155
31527089-1	2019	NADPH-thioredoxin reductase C (NTRC) forms a separate thiol-reduction cascade in plastids, combining both NADPH-thioredoxin reductase and thioredoxin activities on a single polypeptide.	Sulfhydryl Compounds	54-59	thioredoxin-like protein CITRX, chloroplastic	Solanum lycopersicum	6-17
31527089-1	2019	NADPH-thioredoxin reductase C (NTRC) forms a separate thiol-reduction cascade in plastids, combining both NADPH-thioredoxin reductase and thioredoxin activities on a single polypeptide.	Sulfhydryl Compounds	54-59	thioredoxin-like protein CITRX, chloroplastic	Solanum lycopersicum	112-123
31527089-1	2019	NADPH-thioredoxin reductase C (NTRC) forms a separate thiol-reduction cascade in plastids, combining both NADPH-thioredoxin reductase and thioredoxin activities on a single polypeptide.	Sulfhydryl Compounds	54-59	thioredoxin-like protein CITRX, chloroplastic	Solanum lycopersicum	112-123
31219655-5	2019	A thiol-derivatized hyaluronan hydrogel cross-linked with polyethyleneglycol diacrylate (PEGDA) was used to topically deliver a cyclized epiviosamine: cP12 and a cyclized engineered variant of cP12 termed cNP8 to porcine, full-thickness, excisional wounds.	Sulfhydryl Compounds	2-7	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	193-197
31654061-6	2019	Mechanistically, H2S was proved to inhibit IKKbeta activity directly via sulfhydrating IKKbeta at cysteinyl residue 179 (C179) in purified recombinant IKKbeta protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKbeta inactivation.	Sulfhydryl Compounds	185-190	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	43-50
31654061-6	2019	Mechanistically, H2S was proved to inhibit IKKbeta activity directly via sulfhydrating IKKbeta at cysteinyl residue 179 (C179) in purified recombinant IKKbeta protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKbeta inactivation.	Sulfhydryl Compounds	185-190	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	87-94
31654061-6	2019	Mechanistically, H2S was proved to inhibit IKKbeta activity directly via sulfhydrating IKKbeta at cysteinyl residue 179 (C179) in purified recombinant IKKbeta protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKbeta inactivation.	Sulfhydryl Compounds	185-190	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	87-94
31654061-6	2019	Mechanistically, H2S was proved to inhibit IKKbeta activity directly via sulfhydrating IKKbeta at cysteinyl residue 179 (C179) in purified recombinant IKKbeta protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKbeta inactivation.	Sulfhydryl Compounds	185-190	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	87-94
31652503-6	2019	Trx1 downregulation counteracted the thiol reductive effect of Sorafenib on Signal Transducer and Activator of Transcription 3 (STAT3) but not on Mitogen-Activated Protein Kinase (MAPK) or Protein Kinase B (Akt) and transformed advanced HCC cells into Sorafenib-sensitive cells.	Sulfhydryl Compounds	37-42	thioredoxin	Homo sapiens	0-4
31356950-2	2019	Various derivatives of human proinsulin were cloned, expressed in E. coli and inclusion bodies prepared under weak acidic conditions (pH 6.5), which protected the native thiols.	Sulfhydryl Compounds	170-176	insulin	Homo sapiens	29-39
31681379-7	2019	Therefore, land plants evolved additional thiol/disulfide-modulating proteins, such as Low Quantum Yield of PSII 1 (LQY1), to aid in the repair and reassembly cycle of PSII.	Sulfhydryl Compounds	42-47	DnaJ/Hsp40 cysteine-rich domain superfamily protein	Arabidopsis thaliana	116-120
31544965-3	2019	Here, we show that the thiol-specific peroxidase peroxiredoxin-4 (Prdx4) directly regulates IL-1beta generation by interfering with caspase-1 activity.	Sulfhydryl Compounds	23-28	peroxiredoxin 4	Mus musculus	49-64
31544965-3	2019	Here, we show that the thiol-specific peroxidase peroxiredoxin-4 (Prdx4) directly regulates IL-1beta generation by interfering with caspase-1 activity.	Sulfhydryl Compounds	23-28	peroxiredoxin 4	Mus musculus	66-71
31544965-3	2019	Here, we show that the thiol-specific peroxidase peroxiredoxin-4 (Prdx4) directly regulates IL-1beta generation by interfering with caspase-1 activity.	Sulfhydryl Compounds	23-28	interleukin 1 beta	Mus musculus	92-100
31544965-3	2019	Here, we show that the thiol-specific peroxidase peroxiredoxin-4 (Prdx4) directly regulates IL-1beta generation by interfering with caspase-1 activity.	Sulfhydryl Compounds	23-28	caspase 1	Mus musculus	132-141
31490648-4	2019	Here, we report the functionalization of pristine CNT films by thiol-ended hyperbranched polymers (THBP-n) via a thiol-ene click reaction that can introduce simultaneous improvements on the strength, modulus, and elongation to the PCNT film by 689, 812, and 32.4%, respectively.	Sulfhydryl Compounds	63-68	crystallin mu	Homo sapiens	99-103
31490648-5	2019	The high thiol content of THBP-n enables the formation of a network with a high degree of cross-linking between carbon nanotubes, which provides high-efficiency load transfer that increases the tensile strength and modulus of the resulting films and at the same time a compressible hyperbranched structure that allows for deformation and slip between CNTs and consequently improved elongation.	Sulfhydryl Compounds	9-14	crystallin mu	Homo sapiens	26-30
31215278-11	2019	PPARgamma agonist improved thiol, SOD and CAT, while diminished MDA concentration.	Sulfhydryl Compounds	27-32	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-9
31288066-7	2019	RA demonstrated to have an inhibitory effect over NRF2 activation, which regulates the expression of thiol antioxidants enzymes.	Sulfhydryl Compounds	101-106	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
31482681-5	2019	Besides, the Fe-N-C SAzymes are applied in biosensor areas to evaluate the activity of acetylcholinesterase based on the inhibition toward nanozyme activity by thiols.	Sulfhydryl Compounds	160-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	87-107
31490631-0	2019	Covalently Binding of Bovine Serum Albumin to Unsaturated Poly(Globalide-Co-epsilon-Caprolactone) Nanoparticles by Thiol-Ene Reactions.	Sulfhydryl Compounds	115-120	albumin	Homo sapiens	29-42
31490631-4	2019	In this work, the surface of poly(globalide-co-epsilon-caprolactone) (PGlCL) nanoparticles containing double bonds in the main polymer chain is covalently functionalized with bovine serum albumin (BSA) by thiol-ene chemistry, producing conjugates which are resistant to dissociation.	Sulfhydryl Compounds	205-210	albumin	Homo sapiens	182-195
31206414-3	2019	This study aimed to investigate the relationship of thiol levels, SH/SS homeostasis, and ischemia-modified albumin (IMA) in patients with beta-thal.	Sulfhydryl Compounds	52-57	albumin	Homo sapiens	107-114
30968345-5	2019	In the present review, we highlight some molecular mechanisms linking tau and Abeta toxicities involving oxidative stress, aging, Abeta turnover, the contribution of thiol groups, and the role mitochondrial activities in the AD pathogenesis.	Sulfhydryl Compounds	166-171	microtubule associated protein tau	Homo sapiens	70-73
30820867-0	2019	Dynamic thiol/disulphide homeostasis in children with neurofibromatosis type 1 and tuberous sclerosis.	Sulfhydryl Compounds	8-13	neurofibromin 1	Homo sapiens	54-78
31251685-8	2019	Moreover, the presence of at least one cysteine residue in all the annotated SLC transporters, so far, highlights the possibility of using the thiol (SH) residue for covalent drug targeting.	Sulfhydryl Compounds	143-148	C-C motif chemokine ligand 21	Homo sapiens	77-80
31278980-2	2019	In addition, the study describes the methodology for the application of these reagents for measuring and imaging of free thiols on cell surfaces as well as their use as pseudo substrates for the thiol reductase and S-nitrosothioldenitrosylase activities of protein disulfide isomerase (PDI) and S-nitrosothiol reductase activity of S-nitrosoglutathione reductase (GSNOR) in vitro and on live cells in culture.	Sulfhydryl Compounds	121-127	prolyl 4-hydroxylase subunit beta	Homo sapiens	257-284
31557852-4	2019	Based on BGERTs and its conjugation with the thiol-terminated polyethylene glycol (PEG) and transferrin, we construct a targeted Transferrin (TF)-PEG-BGERTs SERS nanoprobe and achieve the dynamic imaging of transferrin receptor (TfR) molecules on a single live cell, in which the role of transferrin-conjugated PEG-BGERT is for targeting TfR molecules located in cellular membrane surface.	Sulfhydryl Compounds	45-50	transferrin	Homo sapiens	129-140
31557852-4	2019	Based on BGERTs and its conjugation with the thiol-terminated polyethylene glycol (PEG) and transferrin, we construct a targeted Transferrin (TF)-PEG-BGERTs SERS nanoprobe and achieve the dynamic imaging of transferrin receptor (TfR) molecules on a single live cell, in which the role of transferrin-conjugated PEG-BGERT is for targeting TfR molecules located in cellular membrane surface.	Sulfhydryl Compounds	45-50	transferrin receptor	Homo sapiens	207-227
31557852-4	2019	Based on BGERTs and its conjugation with the thiol-terminated polyethylene glycol (PEG) and transferrin, we construct a targeted Transferrin (TF)-PEG-BGERTs SERS nanoprobe and achieve the dynamic imaging of transferrin receptor (TfR) molecules on a single live cell, in which the role of transferrin-conjugated PEG-BGERT is for targeting TfR molecules located in cellular membrane surface.	Sulfhydryl Compounds	45-50	transferrin receptor	Homo sapiens	229-232
31557852-4	2019	Based on BGERTs and its conjugation with the thiol-terminated polyethylene glycol (PEG) and transferrin, we construct a targeted Transferrin (TF)-PEG-BGERTs SERS nanoprobe and achieve the dynamic imaging of transferrin receptor (TfR) molecules on a single live cell, in which the role of transferrin-conjugated PEG-BGERT is for targeting TfR molecules located in cellular membrane surface.	Sulfhydryl Compounds	45-50	transferrin	Homo sapiens	207-218
31557852-4	2019	Based on BGERTs and its conjugation with the thiol-terminated polyethylene glycol (PEG) and transferrin, we construct a targeted Transferrin (TF)-PEG-BGERTs SERS nanoprobe and achieve the dynamic imaging of transferrin receptor (TfR) molecules on a single live cell, in which the role of transferrin-conjugated PEG-BGERT is for targeting TfR molecules located in cellular membrane surface.	Sulfhydryl Compounds	45-50	transferrin receptor	Homo sapiens	338-341
31501427-2	2019	Here, we reveal that L-plastin (LPL), an established tumor marker, is reversibly regulated by ROS-induced thiol oxidation on Cys101, which forms a disulfide bridge with Cys42.	Sulfhydryl Compounds	106-111	lymphocyte cytosolic protein 1	Homo sapiens	21-30
31501427-2	2019	Here, we reveal that L-plastin (LPL), an established tumor marker, is reversibly regulated by ROS-induced thiol oxidation on Cys101, which forms a disulfide bridge with Cys42.	Sulfhydryl Compounds	106-111	lymphocyte cytosolic protein 1	Homo sapiens	32-35
31320475-1	2019	Dynamic control of thioredoxin (Trx) oxidoreductase activity is essential for balancing the need of cells to rapidly respond to oxidative/nitrosative stress and to temporally regulate thiol-based redox signaling.	Sulfhydryl Compounds	184-189	thioredoxin	Homo sapiens	19-30
31320475-1	2019	Dynamic control of thioredoxin (Trx) oxidoreductase activity is essential for balancing the need of cells to rapidly respond to oxidative/nitrosative stress and to temporally regulate thiol-based redox signaling.	Sulfhydryl Compounds	184-189	thioredoxin	Homo sapiens	32-35
31320475-1	2019	Dynamic control of thioredoxin (Trx) oxidoreductase activity is essential for balancing the need of cells to rapidly respond to oxidative/nitrosative stress and to temporally regulate thiol-based redox signaling.	Sulfhydryl Compounds	184-189	thioredoxin reductase 1	Homo sapiens	37-51
30820867-3	2019	We aimed to investigate the thiol/disulphide balance as an oxidative stress marker in children who suffer from NF1 and TSC.	Sulfhydryl Compounds	28-33	neurofibromin 1	Homo sapiens	111-114
31343087-4	2019	Specifically, thiol-based self-assembled monolayers (SAMs), 4-methylbenzenethiol (MBT) and pentafluorobenzenethiol (PFBT), are used to investigate contact resistance in n-type accumulation-mode OECTs made from the hydrophilic copolymer P-90, where the deliberate functionalization of the gold source/drain electrodes decreases and increases the energetic mismatch at the electrode/semiconductor interface, respectively.	Sulfhydryl Compounds	14-19	cellular inhibitor of PP2A	Homo sapiens	236-240
30820867-3	2019	We aimed to investigate the thiol/disulphide balance as an oxidative stress marker in children who suffer from NF1 and TSC.	Sulfhydryl Compounds	28-33	TSC complex subunit 1	Homo sapiens	119-122
30820867-7	2019	The total thiol, native thiol, and disulfide level was lower in TSC and NF1 group than the healthy control group.	Sulfhydryl Compounds	10-15	TSC complex subunit 1	Homo sapiens	64-67
30820867-7	2019	The total thiol, native thiol, and disulfide level was lower in TSC and NF1 group than the healthy control group.	Sulfhydryl Compounds	10-15	neurofibromin 1	Homo sapiens	72-75
30820867-7	2019	The total thiol, native thiol, and disulfide level was lower in TSC and NF1 group than the healthy control group.	Sulfhydryl Compounds	24-29	TSC complex subunit 1	Homo sapiens	64-67
30820867-7	2019	The total thiol, native thiol, and disulfide level was lower in TSC and NF1 group than the healthy control group.	Sulfhydryl Compounds	24-29	neurofibromin 1	Homo sapiens	72-75
30820867-9	2019	We detected that the total thiol, native thiol, and disulfide levels were lower in TSC and NF1 group than the healthy control group.	Sulfhydryl Compounds	27-32	TSC complex subunit 1	Homo sapiens	83-86
30820867-9	2019	We detected that the total thiol, native thiol, and disulfide levels were lower in TSC and NF1 group than the healthy control group.	Sulfhydryl Compounds	27-32	neurofibromin 1	Homo sapiens	91-94
30820867-9	2019	We detected that the total thiol, native thiol, and disulfide levels were lower in TSC and NF1 group than the healthy control group.	Sulfhydryl Compounds	41-46	TSC complex subunit 1	Homo sapiens	83-86
30820867-9	2019	We detected that the total thiol, native thiol, and disulfide levels were lower in TSC and NF1 group than the healthy control group.	Sulfhydryl Compounds	41-46	neurofibromin 1	Homo sapiens	91-94
31165553-7	2019	A bis-NHC-ligated Pt species generated from the hydrolysis of 1 a forms adducts with thiols and appears to target an active-site cysteine of ASNS.	Sulfhydryl Compounds	85-91	asparagine synthetase	Mus musculus	141-145
31132430-4	2019	We found oxidization of cysteines (cysteines with oxidized thiol groups) in KEAP1 protein with a weaker interaction between NRF2 and KEAP1, following ABS exposure.	Sulfhydryl Compounds	59-64	kelch like ECH associated protein 1	Homo sapiens	76-81
31555141-1	2019	Objective: Mitochondrial thioredoxin 2 (Trx2) is a vital mitochondrial redox protein that mediates normal protein thiol reduction and provides electrons to peroxiredoxin 3 (Prx3) to scavenge H2O2 in mitochondria.	Sulfhydryl Compounds	114-119	thioredoxin 2	Mus musculus	40-44
31319664-7	2019	In addition, such probe presents an excellent selective ratiometric response to H2S relative to other anionic species and thiols because of the specific interaction between Pd2+ and H2S.	Sulfhydryl Compounds	122-128	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	173-176
31497710-1	2019	In this study, we investigate the adsorption capability of molybdenum sulfide (MoS2)/thiol-functionalized multiwalled carbon nanotube (SH-MWCNT) nanocomposite for rapid and efficient removal of heavy metals [Pb(II) and Cd(II)] from industrial mine water.	Sulfhydryl Compounds	85-90	submaxillary gland androgen regulated protein 3B	Homo sapiens	208-214
31485294-6	2019	The thiol-antioxidant NAC prevented the EV induction by CSE in epithelial cells and fibroblasts.	Sulfhydryl Compounds	4-9	synuclein alpha	Homo sapiens	22-25
31217277-1	2019	Thiol-based redox regulation via ferredoxin-thioredoxin (Trx) reductase/Trx controls various functions in chloroplasts in response to light/dark changes.	Sulfhydryl Compounds	0-5	thioredoxin H-type 1	Arabidopsis thaliana	44-55
31217277-1	2019	Thiol-based redox regulation via ferredoxin-thioredoxin (Trx) reductase/Trx controls various functions in chloroplasts in response to light/dark changes.	Sulfhydryl Compounds	0-5	thioredoxin H-type 1	Arabidopsis thaliana	57-60
31217277-1	2019	Thiol-based redox regulation via ferredoxin-thioredoxin (Trx) reductase/Trx controls various functions in chloroplasts in response to light/dark changes.	Sulfhydryl Compounds	0-5	thioredoxin H-type 1	Arabidopsis thaliana	72-75
31398901-5	2019	Both the glycone moiety and the aglycone tail can be modified by using sp2-iminosugar precursors with different configurational profiles (d-gluco or d-galacto in this work) and varied thiols, as well as by oxidation of the sulfide adducts (to the corresponding sulfones in this work).	Sulfhydryl Compounds	184-190	Sp2 transcription factor	Homo sapiens	71-74
31497343-4	2019	Activation of integrins can be promoted by thiol-disulfide exchanges initiated by Protein Disulfide Isomerase (PDI).	Sulfhydryl Compounds	43-48	prolyl 4-hydroxylase subunit beta	Homo sapiens	82-109
31497343-4	2019	Activation of integrins can be promoted by thiol-disulfide exchanges initiated by Protein Disulfide Isomerase (PDI).	Sulfhydryl Compounds	43-48	prolyl 4-hydroxylase subunit beta	Homo sapiens	111-114
31497343-7	2019	Furthermore, we prove that the transendothelial migration of MDA-MB-231 cells and contraction of collagen can be blocked by thiol blockers or PDI inhibitors and that these factors affect exposition of free thiols on integrin molecules.	Sulfhydryl Compounds	206-212	prolyl 4-hydroxylase subunit beta	Homo sapiens	142-145
31243395-3	2019	By injecting a uracil analog, 4-thiouracil, into transgenic mice that express cell-type-specific uracil phosphoribosyltransferase (UPRT), an enzyme required for 4-thiouracil incorporation into newly synthesized RNA, only cells expressing UPRT synthesize thiol-containing RNA.	Sulfhydryl Compounds	254-259	uracil phosphoribosyltransferase	Mus musculus	131-135
31087497-1	2019	Bovine beta-lactoglobulin (BLG) is a major whey protein with unique structural characteristics: it possesses a free Cys thiol (SH) and two disulfide (SS) bonds and consists of a beta-barrel core surrounded by one long and several short alpha helices.	Sulfhydryl Compounds	120-125	beta-lactoglobulin	Bos taurus	7-25
31087497-1	2019	Bovine beta-lactoglobulin (BLG) is a major whey protein with unique structural characteristics: it possesses a free Cys thiol (SH) and two disulfide (SS) bonds and consists of a beta-barrel core surrounded by one long and several short alpha helices.	Sulfhydryl Compounds	120-125	beta-lactoglobulin	Bos taurus	27-30
31087497-9	2019	These findings are informative not only for elucidating oxidative folding pathways of other members of the beta-lactoglobulin family, but also for understanding the roles of a redundant Cys thiol in the oxidative folding process of a protein with odd Cys residues.	Sulfhydryl Compounds	190-195	beta-lactoglobulin	Bos taurus	107-125
31042499-5	2019	Inhibiting extracellular PDI mimics thiol blocking.	Sulfhydryl Compounds	36-41	prolyl 4-hydroxylase subunit beta	Homo sapiens	25-28
31147200-3	2019	Modulation of neurokinin A levels may also be related to the effect of thiol drugs on oxidative stress.	Sulfhydryl Compounds	71-76	tachykinin precursor 1	Homo sapiens	14-26
31409973-8	2019	CCl4 treatment increased malondialdehyde (MDA) level and decreased nonprotein thiol (NP-SH) and total protein (TP) in liver tissues.	Sulfhydryl Compounds	78-83	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
30859693-2	2019	Of particular interest are recent advances in assembling MOF materials equipped with free-standing thiol functions: metal guests can be conveniently inserted to install electroactive metal-sulfur bonds, which, as crosslinks, also stabilize the host coordination net.	Sulfhydryl Compounds	99-104	lysine acetyltransferase 8	Homo sapiens	57-60
30859693-3	2019	Here the historical development of the bifunctional, two-step design embodied by the thiol-tagged MOF solids is traced, in order to highlight the underlying spirit that has driven research efforts in the past two decades.	Sulfhydryl Compounds	85-90	lysine acetyltransferase 8	Homo sapiens	98-101
30917742-7	2019	There was a correlation between the sperm MMP2 activity and the total thiol group (TTG) (r = 0.276, p &lt; .05) and the total antioxidant capacity (TAC) of seminal plasma (r = 0.304, p &lt; .05).	Sulfhydryl Compounds	70-75	matrix metallopeptidase 2	Homo sapiens	42-46
31111667-7	2019	GAPDH, with a thiol group in its active site, is more sensitive to Ag than MDH, displaying many thiol groups but none in its active site, suggesting that thiol groups at the active site strongly determines the sensitivity of enzymes toward AgNPs.	Sulfhydryl Compounds	14-19	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
31111667-7	2019	GAPDH, with a thiol group in its active site, is more sensitive to Ag than MDH, displaying many thiol groups but none in its active site, suggesting that thiol groups at the active site strongly determines the sensitivity of enzymes toward AgNPs.	Sulfhydryl Compounds	14-19	malic enzyme 1	Homo sapiens	75-78
31111667-7	2019	GAPDH, with a thiol group in its active site, is more sensitive to Ag than MDH, displaying many thiol groups but none in its active site, suggesting that thiol groups at the active site strongly determines the sensitivity of enzymes toward AgNPs.	Sulfhydryl Compounds	96-101	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
31111667-7	2019	GAPDH, with a thiol group in its active site, is more sensitive to Ag than MDH, displaying many thiol groups but none in its active site, suggesting that thiol groups at the active site strongly determines the sensitivity of enzymes toward AgNPs.	Sulfhydryl Compounds	96-101	malic enzyme 1	Homo sapiens	75-78
31111667-7	2019	GAPDH, with a thiol group in its active site, is more sensitive to Ag than MDH, displaying many thiol groups but none in its active site, suggesting that thiol groups at the active site strongly determines the sensitivity of enzymes toward AgNPs.	Sulfhydryl Compounds	96-101	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
31111667-7	2019	GAPDH, with a thiol group in its active site, is more sensitive to Ag than MDH, displaying many thiol groups but none in its active site, suggesting that thiol groups at the active site strongly determines the sensitivity of enzymes toward AgNPs.	Sulfhydryl Compounds	96-101	malic enzyme 1	Homo sapiens	75-78
31165811-2	2019	Different from the previous probes, we developed a fluorescent probe enabling the detection of intracellular GSTs in a low GSH level environment by pre-treatment of the cells with thiol-scavengers.	Sulfhydryl Compounds	180-185	glutathione S-transferase kappa 1	Homo sapiens	109-113
31243577-0	2019	Disposable paper-based electrochemical sensor using thiol-terminated poly(2-methacryloyloxyethyl phosphorylcholine) for the label-free detection of C-reactive protein.	Sulfhydryl Compounds	52-57	C-reactive protein	Homo sapiens	148-166
31243577-11	2019	Graphical abstract Schematic presentation of highly sensitive and disposable paper-based electrochemical sensor using thiol-terminated poly(2-methacryloyloxyethyl phosphorylcholine) in the presence of Ca2+ for the label-free C-reactive protein detection.	Sulfhydryl Compounds	118-123	C-reactive protein	Homo sapiens	225-243
30924279-4	2019	Rapid persulfidation leading to complete thiol oxidation of TTP mediated by H2 S was observed by low-temperature ESI-MS and fluorescence spectroscopy.	Sulfhydryl Compounds	41-46	ZFP36 ring finger protein	Homo sapiens	60-63
31117737-1	2019	pH/reduction dual-triggered chicken-feather-keratin-based prodrug nanoparticles (C-PK/- SS-Hy-D NPs) were designed via a facile one-pot oxidation coupling reaction between the thiol-functional acid-labile prodrug M-Hy-D and the PEGylated keratin (PK) graft copolymer, for tumor intracellular doxorubicin (DOX) delivery.	Sulfhydryl Compounds	176-181	keratin	Gallus gallus	44-51
29792351-1	2019	Aims: Peroxiredoxins (PRDXs) are thiol-specific antioxidant enzymes that regulate redox balance that are critical for maintaining the cellular potential for self-renewal and stemness.	Sulfhydryl Compounds	33-38	peroxiredoxin 6	Mus musculus	6-20
30971427-3	2019	Because oxidation of cell-surface thiols also alters protein functionality, we hypothesized that increasing the levels of thioredoxin (Trx), an antioxidant molecule facilitating reduction of proteins through cysteine thiol-disulfide exchange, in T cells will promote their sustained antitumor function.	Sulfhydryl Compounds	34-40	thioredoxin 1	Mus musculus	122-133
30971427-3	2019	Because oxidation of cell-surface thiols also alters protein functionality, we hypothesized that increasing the levels of thioredoxin (Trx), an antioxidant molecule facilitating reduction of proteins through cysteine thiol-disulfide exchange, in T cells will promote their sustained antitumor function.	Sulfhydryl Compounds	34-40	thioredoxin 1	Mus musculus	135-138
30971427-3	2019	Because oxidation of cell-surface thiols also alters protein functionality, we hypothesized that increasing the levels of thioredoxin (Trx), an antioxidant molecule facilitating reduction of proteins through cysteine thiol-disulfide exchange, in T cells will promote their sustained antitumor function.	Sulfhydryl Compounds	34-39	thioredoxin 1	Mus musculus	122-133
30971427-3	2019	Because oxidation of cell-surface thiols also alters protein functionality, we hypothesized that increasing the levels of thioredoxin (Trx), an antioxidant molecule facilitating reduction of proteins through cysteine thiol-disulfide exchange, in T cells will promote their sustained antitumor function.	Sulfhydryl Compounds	34-39	thioredoxin 1	Mus musculus	135-138
30921659-3	2019	In aqueous solution, TCF-Cys, which with an acrylate extremity as a recognizing unit, exhibited excellent "turn-on" fluorescence response for Cys superior to other amino acids and thiols with a limit of detection of 0.1323 muM.	Sulfhydryl Compounds	180-186	ETS transcription factor ELK4	Danio rerio	21-24
31092800-1	2019	Thioester surfactants, [C12H25N(CH3)2(CH2)mSCOCH3] Br (C12mSAc, m = 4, 11, 12), yielded thiol surfactants via thiol-thioester exchange upon addition of dithiothreitol in aqueous solution.	Sulfhydryl Compounds	88-93	chromosome 12 open reading frame 73	Homo sapiens	51-53
31092800-1	2019	Thioester surfactants, [C12H25N(CH3)2(CH2)mSCOCH3] Br (C12mSAc, m = 4, 11, 12), yielded thiol surfactants via thiol-thioester exchange upon addition of dithiothreitol in aqueous solution.	Sulfhydryl Compounds	110-115	chromosome 12 open reading frame 73	Homo sapiens	51-53
30842219-6	2019	Treatment of WT-PLN with HNO leads to sulfinamide formation when the HNO donor is in excess, whereas disulfide formation is expected to dominate when the HNO/thiol stoichiometry approaches a 1:1 ratio that is more similar to that anticipated in vivo under normal, physiological conditions.	Sulfhydryl Compounds	158-163	phospholamban	Homo sapiens	16-19
30073465-4	2019	The inhibitory effects of P-13 on JAK2/STAT3 signaling could be blocked by reducing agents dithiothreitol (DTT) or glutathione (GSH), indicating an involvement of the thiol-reactive alpha-beta unsaturated carbonyl group in P-13.	Sulfhydryl Compounds	167-172	H3 histone pseudogene 6	Homo sapiens	26-30
30875500-6	2019	Therefore, we developed a fluorescent method to quantify thiol groups in HA with N-(1-pyrenyl) maleimide (NPM).	Sulfhydryl Compounds	57-62	nucleophosmin 1	Homo sapiens	106-109
31177989-7	2019	Both the all-thiol and disulfide types of HMGB1 induced CitH3 via their specific receptors, CXCR4 and TLR4, respectively.	Sulfhydryl Compounds	13-18	C-X-C motif chemokine receptor 4	Rattus norvegicus	92-97
31177989-7	2019	Both the all-thiol and disulfide types of HMGB1 induced CitH3 via their specific receptors, CXCR4 and TLR4, respectively.	Sulfhydryl Compounds	13-18	toll-like receptor 4	Rattus norvegicus	102-106
30853337-7	2019	RESULTS: The thiol-containing form of homocysteine (HcySH) suppressed phosphorylation of insulin receptor-beta subunit, but enhanced PTP1B activity.	Sulfhydryl Compounds	13-18	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	133-138
30861549-0	2019	Role of Cell Surface Lipids and Thiol-Disulphide Exchange Pathways in Regulating the Encryption and Decryption of Tissue Factor.	Sulfhydryl Compounds	32-37	coagulation factor III, tissue factor	Homo sapiens	114-127
30861549-8	2019	To date, externalization of phosphatidylserine to the outer leaflet and thiol-disulphide exchange pathways that either turn on and off the allosteric disulphide bond in TF are shown to play a major role in regulating TF pro-coagulant activity on cell surfaces.	Sulfhydryl Compounds	72-77	coagulation factor III, tissue factor	Homo sapiens	169-171
30861549-8	2019	To date, externalization of phosphatidylserine to the outer leaflet and thiol-disulphide exchange pathways that either turn on and off the allosteric disulphide bond in TF are shown to play a major role in regulating TF pro-coagulant activity on cell surfaces.	Sulfhydryl Compounds	72-77	coagulation factor III, tissue factor	Homo sapiens	217-219
31026148-3	2019	This iron(II) thiolate dinuclear complex, [FeII2(LS)(LSH)] ([Fe2SH]+) (LS2- = 2,2"-(2,2"-bipyridine-6,6"-diyl)bis(1,1-diphenylethanethiolate)) contains a thiol group in the metal coordination sphere.	Sulfhydryl Compounds	14-19	helicase, lymphoid specific	Homo sapiens	53-56
30740917-0	2019	Anchoring CoII Ions into a Thiol-Laced Metal-Organic Framework for Efficient Visible-Light-Driven Conversion of CO2 into CO.	Sulfhydryl Compounds	27-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	10-14
30740917-3	2019	To address this, catalytically active CoII centers can be anchored into the porous matrix of metal-organic frameworks (MOFs) by utilizing a robust Zr-based MOF (Zr-DMBD) functionalized with freestanding thiol groups to enable efficient post-synthetic metal insertion.	Sulfhydryl Compounds	203-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-42
31091675-3	2019	Blood Cd2+ binds to thiol-containing high (e.g., albumin, transferrin) and low molecular weight proteins (e.g., the high-affinity metal-binding protein metallothionein, beta2-microglobulin, alpha1-microglobulin and lipocalin-2).	Sulfhydryl Compounds	20-25	albumin	Rattus norvegicus	49-56
30876583-0	2019	One-step fabrication of cinchona-based hybrid monolithic chiral stationary phases via photo-initiated thiol-ene polymerization for cLC enantioseparation.	Sulfhydryl Compounds	102-107	Charcot-Leyden crystal galectin	Homo sapiens	131-134
30812058-3	2019	METHODS: A novel strategy based on a thiol-specific stable isotopic labelling reagent was developed to determine the binding ratio of metal-based anticancer complexes, namely cisplatin and organometallic ruthenium complex [(eta6 -biphenyl)RuCl(en)]PF6 (en = ethylenediamine), with the cysteinyl residues of Atox1.	Sulfhydryl Compounds	37-42	sperm associated antigen 17	Homo sapiens	248-251
30812058-3	2019	METHODS: A novel strategy based on a thiol-specific stable isotopic labelling reagent was developed to determine the binding ratio of metal-based anticancer complexes, namely cisplatin and organometallic ruthenium complex [(eta6 -biphenyl)RuCl(en)]PF6 (en = ethylenediamine), with the cysteinyl residues of Atox1.	Sulfhydryl Compounds	37-42	antioxidant 1 copper chaperone	Homo sapiens	307-312
30739756-5	2019	Oxidation of residual thiols yielded a zwitterionic Poly-RP/WAX/SCX mixed-mode phase with sulfonic acid endcapping and shifted the still net positive surface charge to lower zeta-potentials.	Sulfhydryl Compounds	22-28	scleraxis bHLH transcription factor	Homo sapiens	64-67
31017422-5	2019	Incubation of 3T3-L1 cells for 48 h with amino acid side chain oxidation and glycation products (1 and 10 muM) resulted in a loss (up to 40%, p &lt; 0.05) of cell thiols and decreased metabolic activity compared with those of the controls.	Sulfhydryl Compounds	163-169	latexin	Homo sapiens	106-109
31020285-2	2019	In the presence of 1 mol% NHC, various thiols underwent the sulfa-Michael-Michael cascade reaction with benzenedi(enones) efficiently to form the carbon-sulfur bond and construct sulfenylated indanes in good to excellent yields with high diastereoselectivity.	Sulfhydryl Compounds	39-45	high mobility group nucleosomal binding domain 4	Homo sapiens	26-29
31020285-3	2019	In addition, the NHC-catalyzed sulfa-Michael-aldol cascade reaction between o-formyl chalcone and thiols has also been demonstrated to afford sulfenylated indanes with a free hydroxyl group in moderate yields and good diastereoselectivity.	Sulfhydryl Compounds	98-104	high mobility group nucleosomal binding domain 4	Homo sapiens	17-20
31020297-4	2019	AChE can hydrolyze acetylthiocholine (ATCh) to form thiocholine (TCh) which contains a thiol group.	Sulfhydryl Compounds	87-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4
31017793-0	2019	Chemoselective Synthesis of N-Terminal Cysteinyl Thioesters via beta,gamma-C,S Thiol-Michael Addition.	Sulfhydryl Compounds	79-84	interleukin 2 receptor subunit gamma	Homo sapiens	69-76
31017793-2	2019	Herein, we report an efficient synthesis of N-terminal cysteinyl thioesters, suitable for S, N-acyl transfer, based on beta,gamma-C,S thiol-Michael addition.	Sulfhydryl Compounds	134-139	interleukin 2 receptor subunit gamma	Homo sapiens	124-131
31129031-8	2019	We observed that the thiol reducing agent, dithiothreitol abrogated 15-keto PGE2-induced STAT3 inactivation and disrupted the direct interaction between 15-keto PGE2 and STAT3.	Sulfhydryl Compounds	21-26	signal transducer and activator of transcription 3	Homo sapiens	89-94
31129031-8	2019	We observed that the thiol reducing agent, dithiothreitol abrogated 15-keto PGE2-induced STAT3 inactivation and disrupted the direct interaction between 15-keto PGE2 and STAT3.	Sulfhydryl Compounds	21-26	signal transducer and activator of transcription 3	Homo sapiens	170-175
31129031-11	2019	Taken together, thiol modification of STAT3 by 15-keto PGE2 inactivates STAT3 which may account for its suppression of breast cancer cell proliferation and progression.	Sulfhydryl Compounds	16-21	signal transducer and activator of transcription 3	Homo sapiens	38-43
31129031-11	2019	Taken together, thiol modification of STAT3 by 15-keto PGE2 inactivates STAT3 which may account for its suppression of breast cancer cell proliferation and progression.	Sulfhydryl Compounds	16-21	signal transducer and activator of transcription 3	Homo sapiens	72-77
30854738-5	2019	A cytotoxic molecule was then connected to the newly introduced thiol group, and both a surface plasmon resonance binding assay and in vivo xenograft mouse model results showed that the resulting ADC could selectively target and kill HER2-positive cells.	Sulfhydryl Compounds	64-69	erb-b2 receptor tyrosine kinase 2	Mus musculus	234-238
30367780-2	2019	The thioredoxin family of proteins like thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomerase, are involved in the formation, transfer or isomerization of disulfide bonds through a characteristic thiol-disulfide exchange reaction.	Sulfhydryl Compounds	212-217	thioredoxin	Homo sapiens	4-15
30367780-2	2019	The thioredoxin family of proteins like thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomerase, are involved in the formation, transfer or isomerization of disulfide bonds through a characteristic thiol-disulfide exchange reaction.	Sulfhydryl Compounds	212-217	thioredoxin	Homo sapiens	40-51
30367780-2	2019	The thioredoxin family of proteins like thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomerase, are involved in the formation, transfer or isomerization of disulfide bonds through a characteristic thiol-disulfide exchange reaction.	Sulfhydryl Compounds	212-217	thioredoxin	Homo sapiens	53-56
30367780-2	2019	The thioredoxin family of proteins like thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomerase, are involved in the formation, transfer or isomerization of disulfide bonds through a characteristic thiol-disulfide exchange reaction.	Sulfhydryl Compounds	212-217	glutaredoxin	Homo sapiens	59-71
30367780-2	2019	The thioredoxin family of proteins like thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomerase, are involved in the formation, transfer or isomerization of disulfide bonds through a characteristic thiol-disulfide exchange reaction.	Sulfhydryl Compounds	212-217	glutaredoxin	Homo sapiens	73-76
31080419-8	2019	Patients with CD with above-average free thiols had significantly lower CRP levels (median 1.4 [interquartile range] [0.4; 2.6] vs. 3.6 [0.6; 7.0] mg/L; P &lt; 0.05) and BMI (23.6 +- 4.8 vs. 27.1 +- 5.2 kg/m2; P &lt; 0.05).	Sulfhydryl Compounds	41-47	C-reactive protein	Homo sapiens	72-75
31080419-10	2019	Finally, plasma free thiol concentrations negatively correlated with biomarkers of inflammation, including hsCRP, SAA, IL-17A (all P &lt; 0.05), and VEGF.	Sulfhydryl Compounds	21-26	serum amyloid A1 cluster	Homo sapiens	114-117
31080419-10	2019	Finally, plasma free thiol concentrations negatively correlated with biomarkers of inflammation, including hsCRP, SAA, IL-17A (all P &lt; 0.05), and VEGF.	Sulfhydryl Compounds	21-26	interleukin 17A	Homo sapiens	119-125
31080419-10	2019	Finally, plasma free thiol concentrations negatively correlated with biomarkers of inflammation, including hsCRP, SAA, IL-17A (all P &lt; 0.05), and VEGF.	Sulfhydryl Compounds	21-26	vascular endothelial growth factor A	Homo sapiens	149-153
30611810-1	2019	In this study, a novel and efficient aptasensor based on immobilization of thiol terminated prostate specific antigen (PSA) binding DNA aptamer onto Au nanoparticles/fullerene C60-chitosan-ionic liquid/multiwalled carbon nanotubes/screen printed carbon electrode has been fabricated for ultrasensitive aptasensing of biomarker PSA.	Sulfhydryl Compounds	75-80	kallikrein related peptidase 3	Homo sapiens	92-117
31052910-5	2019	Here, we demonstrate the capability of gold strip gratings fabricated on a CaF2 substrate to enhance the CH2 vibrational modes of a thiol-based monolayer of MHDA.	Sulfhydryl Compounds	132-137	CCR4-NOT transcription complex subunit 8	Homo sapiens	75-79
31019520-9	2019	Here, we update the current knowledge of these two redox systems focusing on recent evidence showing their functional interrelationship through the action of the thiol-dependent peroxidase, 2-Cys peroxiredoxin (2-Cys Prx).	Sulfhydryl Compounds	162-167	periaxin	Homo sapiens	217-220
30899997-4	2019	The specificity of thiol-gold interaction was demonstrated over allyl-rich thiol-ene surfaces and the robustness of the CHT-IMERs at different flow rates and reaction temperatures using bradykinin hydrolysis as the model reaction.	Sulfhydryl Compounds	19-24	kininogen 1	Homo sapiens	186-196
30611810-1	2019	In this study, a novel and efficient aptasensor based on immobilization of thiol terminated prostate specific antigen (PSA) binding DNA aptamer onto Au nanoparticles/fullerene C60-chitosan-ionic liquid/multiwalled carbon nanotubes/screen printed carbon electrode has been fabricated for ultrasensitive aptasensing of biomarker PSA.	Sulfhydryl Compounds	75-80	kallikrein related peptidase 3	Homo sapiens	119-122
30611810-1	2019	In this study, a novel and efficient aptasensor based on immobilization of thiol terminated prostate specific antigen (PSA) binding DNA aptamer onto Au nanoparticles/fullerene C60-chitosan-ionic liquid/multiwalled carbon nanotubes/screen printed carbon electrode has been fabricated for ultrasensitive aptasensing of biomarker PSA.	Sulfhydryl Compounds	75-80	kallikrein related peptidase 3	Homo sapiens	327-330
30741476-3	2019	The anti-adhesion activity appears to depend on the terminal free thiols of HNP-1, which may inhibit VWF-VWF lateral associations.	Sulfhydryl Compounds	66-72	HNP1	Homo sapiens	76-81
30653415-7	2019	A greater protein expression level of endogenous thiol antioxidant thioredoxin (TRX) was observed among iron-loaded muscle whereas its endogenous inhibitor thioredoxin-interacting protein (TXNip) and the TRX/TXNip ratio were similar.	Sulfhydryl Compounds	49-54	thioredoxin 1	Mus musculus	67-78
30653415-7	2019	A greater protein expression level of endogenous thiol antioxidant thioredoxin (TRX) was observed among iron-loaded muscle whereas its endogenous inhibitor thioredoxin-interacting protein (TXNip) and the TRX/TXNip ratio were similar.	Sulfhydryl Compounds	49-54	thioredoxin 1	Mus musculus	80-83
30653415-7	2019	A greater protein expression level of endogenous thiol antioxidant thioredoxin (TRX) was observed among iron-loaded muscle whereas its endogenous inhibitor thioredoxin-interacting protein (TXNip) and the TRX/TXNip ratio were similar.	Sulfhydryl Compounds	49-54	thioredoxin interacting protein	Mus musculus	208-213
30741476-3	2019	The anti-adhesion activity appears to depend on the terminal free thiols of HNP-1, which may inhibit VWF-VWF lateral associations.	Sulfhydryl Compounds	66-72	Von Willebrand factor	Mus musculus	101-104
30741476-3	2019	The anti-adhesion activity appears to depend on the terminal free thiols of HNP-1, which may inhibit VWF-VWF lateral associations.	Sulfhydryl Compounds	66-72	Von Willebrand factor	Mus musculus	105-108
30741476-12	2019	Conclusions Our results demonstrate for the first time an antiplatelet adhesion or antithrombotic activity of HNP-1; this activity depends on its terminal free thiols, likely affecting VWF-VWF lateral associations.	Sulfhydryl Compounds	160-166	HNP1	Homo sapiens	110-115
30602565-0	2019	A new class of recombinant human albumin with multiple surface thiols exhibits stable conjugation and enhanced FcRn binding and blood circulation.	Sulfhydryl Compounds	63-69	Fc gamma receptor and transporter	Homo sapiens	111-115
30678949-0	2019	Silver nanoparticles decorated on thiol-modified magnetite nanoparticles (Fe3O4/SiO2-Pr-S-Ag) as a recyclable nanocatalyst for degradation of organic dyes.	Sulfhydryl Compounds	34-39	S-antigen visual arrestin	Homo sapiens	88-92
30678949-1	2019	Surface modification of Fe3O4 nanoparticle with thiol groups was used for the immobilization of silver nano-particles to produce Fe3O4/SiO2-Pr-S-Ag NPs.	Sulfhydryl Compounds	48-53	S-antigen visual arrestin	Homo sapiens	143-147
30156702-5	2019	When AtGAL was incubated in the presence of a thiol-reducing reagent prior to immunoblotting, its cross-reactivity with anti-AtGAL1-IgG was markedly attenuated (consistent with three predicted disulfide bonds in AtGAL1"s apple domain).	Sulfhydryl Compounds	46-51	Mevalonate/galactokinase family protein	Arabidopsis thaliana	125-131
30156702-5	2019	When AtGAL was incubated in the presence of a thiol-reducing reagent prior to immunoblotting, its cross-reactivity with anti-AtGAL1-IgG was markedly attenuated (consistent with three predicted disulfide bonds in AtGAL1"s apple domain).	Sulfhydryl Compounds	46-51	Mevalonate/galactokinase family protein	Arabidopsis thaliana	212-218
31496908-0	2019	Thiol/Disulphide Homeostasis, Ischemia Modified Albumin, and Ferroxidase as Oxidative Stress Markers in Women with Obesity with Insulin Resistance.	Sulfhydryl Compounds	0-5	insulin	Homo sapiens	128-135
30602565-5	2019	The thiol rHSA variants exhibited up to 95% monomeric stability over 24 months and retained hFcRn engagement compared with a WT unconjugated control demonstrated by Biolayer Interferometry.	Sulfhydryl Compounds	4-9	Fc gamma receptor and transporter	Homo sapiens	92-97
30602565-8	2019	We also observed a 1.3-fold increase in the blood circulatory half-life of a high hFcRn-binding triple-thiol variant conjugated with AF680 (t 1/2 = 22.4 h) compared with its WT counterpart (t 1/2 = 17.3 h) in mice.	Sulfhydryl Compounds	103-108	Fc gamma receptor and transporter	Homo sapiens	82-87
30658969-3	2019	The role of the yeast gene IRC7 in thiol release has been well established, and it has been shown that a 38-bp deletion found in many wine strains cause them to express a truncated version of Irc7p that does not possess cysteine-S-conjugate beta-lyase activity.	Sulfhydryl Compounds	35-40	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	27-31
30658969-3	2019	The role of the yeast gene IRC7 in thiol release has been well established, and it has been shown that a 38-bp deletion found in many wine strains cause them to express a truncated version of Irc7p that does not possess cysteine-S-conjugate beta-lyase activity.	Sulfhydryl Compounds	35-40	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	192-197
30658969-5	2019	Screening of a large number of strains coupled with analysis of genomic sequence data allowed us to identify several previously undescribed single-nucleotide polymorphisms (SNPs) in IRC7 that, when coupled with allele length, more robustly explain the ability of a particular yeast strain to release thiols from their cysteinylated precursors.	Sulfhydryl Compounds	300-306	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	182-186
30658969-6	2019	We also demonstrate that allelic variation of IRC7 not only affects the release of thiols but modulates the formation of negative volatile sulfur compounds from the amino acid cysteine.	Sulfhydryl Compounds	83-89	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	46-50
30611847-10	2019	Further optimization of non-covalent interaction and thiol-reactivity provides opportunities to develop therapeutic useful covalent HDAC8 inhibitors.	Sulfhydryl Compounds	53-58	histone deacetylase 8	Homo sapiens	132-137
30739449-5	2019	The decrease of hydrogen peroxide and increase of free thiol groups in wCat1-treated dough suggest that the decomposition of hydrogen peroxide by wCat1 likely promotes disulfide-bond formation and thus the cross-linking of dough proteins.	Sulfhydryl Compounds	55-60	catalase-1	Triticum aestivum	71-76
30739449-5	2019	The decrease of hydrogen peroxide and increase of free thiol groups in wCat1-treated dough suggest that the decomposition of hydrogen peroxide by wCat1 likely promotes disulfide-bond formation and thus the cross-linking of dough proteins.	Sulfhydryl Compounds	55-60	catalase-1	Triticum aestivum	146-151
30855255-0	2019	Reactions of Rh2(CH3COO)4 with thiols and thiolates: a structural study.	Sulfhydryl Compounds	31-37	Rh associated glycoprotein	Homo sapiens	13-16
30841428-3	2019	A selected aptamer - AS1411 - selective towards nucleolin, with a terminal thiol group was conjugated to HGNs.	Sulfhydryl Compounds	75-80	nucleolin	Homo sapiens	48-57
30593501-0	2019	Kinetic studies reveal a key role of a redox-active glutaredoxin in the evolution of the thiol-redox metabolism of trypanosomatid parasites.	Sulfhydryl Compounds	89-94	glutaredoxin	Homo sapiens	52-64
30593501-11	2019	These findings suggest that Grx1 has played an important adaptive role during the rewiring of the thiol-redox metabolism of kinetoplastids.	Sulfhydryl Compounds	98-103	glutaredoxin	Homo sapiens	28-32
30855255-1	2019	The structural differences between the aerobic reaction products of Rh2(AcO)4 (1; AcO- = CH3COO-) with thiols and thiolates in non-aqueous media are probed by X-ray absorption spectroscopy.	Sulfhydryl Compounds	103-109	Rh associated glycoprotein	Homo sapiens	68-77
30601716-7	2019	Misfolding of nascent Tpi1 in response to both cadmium and glucose-depletion stress required both cysteines, implying that thiol status in this protein directly influences folding.	Sulfhydryl Compounds	123-128	triosephosphate isomerase 1	Homo sapiens	22-26
30855255-3	2019	Coordination of simple thiols to the axial positions of Rh2(AcO)4 with Rh-SH bonds of 2.5-2.6 A keeps the RhII-RhII bond intact (2.41 +- 0.02 A) but leads to a colour change from emerald green to burgundy.	Sulfhydryl Compounds	23-29	Rh associated glycoprotein	Homo sapiens	56-65
30587509-2	2019	DMF is known to act by depleting intracellular glutathione and modifying thiols on Keap1 protein, resulting in the stabilization of the transcription factor Nrf2, which in turn induces the expression of antioxidant response element genes.	Sulfhydryl Compounds	73-79	kelch like ECH associated protein 1	Homo sapiens	83-88
30587509-2	2019	DMF is known to act by depleting intracellular glutathione and modifying thiols on Keap1 protein, resulting in the stabilization of the transcription factor Nrf2, which in turn induces the expression of antioxidant response element genes.	Sulfhydryl Compounds	73-79	NFE2 like bZIP transcription factor 2	Homo sapiens	157-161
30601716-9	2019	Moreover, human TPI, mutations in which cause a glycolytic deficiency syndrome, also forms aggregates in response to cadmium treatment, suggesting that this conserved enzyme is folding-labile and may be a useful endogenous model for investigating thiol-specific proteotoxicity.	Sulfhydryl Compounds	247-252	triosephosphate isomerase 1	Homo sapiens	16-19
30601510-4	2019	Herein, we report for the first time, the design, synthesis, physico-chemical characterization and bioactivities of gold nanoparticles covalently functionalized with a thiol ligand containing both shikimoyl and guanidinyl functionalities (Au-SGSH).	Sulfhydryl Compounds	168-173	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	242-246
31872748-44	2019	The identification of Nrf2 pathway in cells exposed to isoprene-derived SOA is in accordance with our findings using the DTT assay, which measures the thiol reactivity of PM samples as a surrogate for their ROS-generation potential.	Sulfhydryl Compounds	151-156	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
31872748-45	2019	Specifically, our results point to the cysteine-thiol modifications within cells that lead to activation of Nrf2-related gene expression.	Sulfhydryl Compounds	39-53	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
30873037-8	2019	S-CMC inhibited CSE-induced SUMO1 modification of HDAC2 in the presence of thiol/GSH, increased HDAC activity, and decreased IL-8 expression.	Sulfhydryl Compounds	75-80	small ubiquitin like modifier 1	Homo sapiens	28-33
30873037-8	2019	S-CMC inhibited CSE-induced SUMO1 modification of HDAC2 in the presence of thiol/GSH, increased HDAC activity, and decreased IL-8 expression.	Sulfhydryl Compounds	75-80	histone deacetylase 2	Homo sapiens	50-55
30873037-3	2019	Our previous studies have shown that carbocisteine (S-CMC) reversed cigarette smoke extract (CSE)-induced down-regulation of HDAC2 expression/activity in a thiol/GSH-dependent manner and enhanced sensitivity of steroid therapy.	Sulfhydryl Compounds	156-161	histone deacetylase 2	Homo sapiens	125-130
30259944-0	2019	Boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols.	Sulfhydryl Compounds	93-99	complement C3	Homo sapiens	23-26
30771096-0	2019	Determination of alkaline phosphatase activity based on enzyme-triggered generation of a thiol and the fluorescence quenching of silver nanoclusters.	Sulfhydryl Compounds	89-94	alkaline phosphatase, placental	Homo sapiens	17-37
30771096-3	2019	ALP catalyzes the dephosphorylation of the thiophosphate amifostine to generate a thiol that binds to the AgNCs and causes its fluorescence to be quenched.	Sulfhydryl Compounds	82-87	alkaline phosphatase, placental	Homo sapiens	0-3
30771096-6	2019	Graphical abstract Alkaline phosphatase (ALP) catalyzes the degradation of amifostine with a generation a thiol product.	Sulfhydryl Compounds	106-111	alkaline phosphatase, placental	Homo sapiens	19-39
30771096-6	2019	Graphical abstract Alkaline phosphatase (ALP) catalyzes the degradation of amifostine with a generation a thiol product.	Sulfhydryl Compounds	106-111	alkaline phosphatase, placental	Homo sapiens	41-44
30771096-7	2019	The thiol quenches the fluorescence of silver nanoclusters, and a method for the detection of ALP down to 0.02 U L-1 was developed.	Sulfhydryl Compounds	4-9	alkaline phosphatase, placental	Homo sapiens	94-97
30259944-1	2019	In this protocol we described a boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols as nucleophiles.	Sulfhydryl Compounds	125-131	complement C3	Homo sapiens	55-58
30469076-3	2019	It was then applied as a transducer to immobilize a thiol-functionalized DNA aptamer via the self-assembled monolayer mechanism for the specific binding of cTnI.	Sulfhydryl Compounds	52-57	troponin I3, cardiac type	Homo sapiens	156-160
30415113-6	2019	PCB 126 modulated glycerophospholipid metabolism, glutathione metabolism, and CoA biosynthesis pathways irrespective of diet; indicating that the disturbance in lipid metabolism and thiol metabolites are general markers of PCB 126 exposure irrespective of liver health.	Sulfhydryl Compounds	182-187	pyruvate carboxylase	Mus musculus	0-3
30442651-5	2019	[14C]Acalabrutinib was metabolized to more than three dozen metabolites detectable by liquid chromatography-tandem mass spectrometry, with primary metabolism by CYP3A-mediated oxidation of the pyrrolidine ring, thiol conjugation of the butynamide warhead, and amide hydrolysis.	Sulfhydryl Compounds	211-216	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	161-166
30645101-6	2019	The QM investigation of the ligand exchange with methanethiol, used as a model of Cys40 of AQP3, was carried out for some derivatives and showed that the affinity of the compounds" binding for thiols is higher in comparison to the Aubipy complex ([AuIII(bipy)Cl2]PF6, bipy = 2,2"-bipyridine).	Sulfhydryl Compounds	193-199	aquaporin 3 (Gill blood group)	Homo sapiens	91-95
30645101-6	2019	The QM investigation of the ligand exchange with methanethiol, used as a model of Cys40 of AQP3, was carried out for some derivatives and showed that the affinity of the compounds" binding for thiols is higher in comparison to the Aubipy complex ([AuIII(bipy)Cl2]PF6, bipy = 2,2"-bipyridine).	Sulfhydryl Compounds	193-199	sperm associated antigen 17	Homo sapiens	263-266
30511403-4	2019	In this report, we optimized the assay conditions and exploited the applications of PEG-switch in quantitation of the extent of protein thiol oxidation in cells in response to H2 O2 and insulin.	Sulfhydryl Compounds	136-141	insulin	Homo sapiens	176-193
30203196-0	2019	Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis.	Sulfhydryl Compounds	9-14	sirtuin 2	Mus musculus	28-33
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Sulfhydryl Compounds	236-241	bone morphogenetic protein 1	Homo sapiens	113-139
30537892-2	2019	After characterization of the chemical structure of TG-DPU using proton nuclear magnetic resonance spectroscopy, bone morphogenetic protein (BMP-2) was loaded in the TG-DPU under oxidative conditions to form disulfides between the free thiol of TG-DPU and BMP-2.	Sulfhydryl Compounds	236-241	bone morphogenetic protein 2	Homo sapiens	141-146
30639960-0	2019	Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches.	Sulfhydryl Compounds	77-82	thioredoxin	Homo sapiens	0-11
30639960-0	2019	Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches.	Sulfhydryl Compounds	77-82	glutaredoxin	Homo sapiens	16-28
30654300-2	2019	Glutathione (GSH) is the most abundant intracellular thiol, protects cellular components from oxidation and is maintained in a reduced state by glutathione reductase (GR).	Sulfhydryl Compounds	53-58	glutathione-disulfide reductase	Homo sapiens	167-169
30639960-1	2019	The aim of the present study was to define the role of Trx and Grx on metabolic thiol redox regulation and identify their protein and metabolite targets.	Sulfhydryl Compounds	80-85	thioredoxin	Homo sapiens	55-58
30639960-1	2019	The aim of the present study was to define the role of Trx and Grx on metabolic thiol redox regulation and identify their protein and metabolite targets.	Sulfhydryl Compounds	80-85	glutaredoxin	Homo sapiens	63-66
30682073-3	2019	Glutaredoxin-1 is a small cytosolic thioltransferase that controls a reversible protein thiol modification, S-glutationylation (protein-GSH adducts), thereby regulating redox signaling.	Sulfhydryl Compounds	36-41	glutaredoxin	Mus musculus	0-14
30552876-0	2019	Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione.	Sulfhydryl Compounds	65-70	glutaredoxin	Homo sapiens	24-36
30552876-0	2019	Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione.	Sulfhydryl Compounds	106-112	glutaredoxin	Homo sapiens	24-36
30508655-8	2019	Therefore, thiol-modified HA and poly(ethylene glycol) diacrylate hydrogels were generated and functionalized with peptides based on ECM known to influence regeneration, including fibronectin, laminin and tenascin-C.	Sulfhydryl Compounds	11-16	fibronectin 1	Homo sapiens	180-191
30425049-9	2019	rTMX1 oxidized thiols in the alphaIIbbeta3 integrin and TMX1-deficient platelets had increased thiols in the beta3 subunit of alphaIIbbeta3, consistent with oxidase activity of rTMX1 against alphaIIbbeta3.	Sulfhydryl Compounds	15-21	thioredoxin-related transmembrane protein 1	Rattus norvegicus	0-5
30425049-9	2019	rTMX1 oxidized thiols in the alphaIIbbeta3 integrin and TMX1-deficient platelets had increased thiols in the beta3 subunit of alphaIIbbeta3, consistent with oxidase activity of rTMX1 against alphaIIbbeta3.	Sulfhydryl Compounds	15-21	thioredoxin-related transmembrane protein 1	Mus musculus	1-5
30425049-9	2019	rTMX1 oxidized thiols in the alphaIIbbeta3 integrin and TMX1-deficient platelets had increased thiols in the beta3 subunit of alphaIIbbeta3, consistent with oxidase activity of rTMX1 against alphaIIbbeta3.	Sulfhydryl Compounds	95-101	thioredoxin-related transmembrane protein 1	Rattus norvegicus	0-5
30425049-9	2019	rTMX1 oxidized thiols in the alphaIIbbeta3 integrin and TMX1-deficient platelets had increased thiols in the beta3 subunit of alphaIIbbeta3, consistent with oxidase activity of rTMX1 against alphaIIbbeta3.	Sulfhydryl Compounds	95-101	thioredoxin-related transmembrane protein 1	Mus musculus	1-5
30508655-8	2019	Therefore, thiol-modified HA and poly(ethylene glycol) diacrylate hydrogels were generated and functionalized with peptides based on ECM known to influence regeneration, including fibronectin, laminin and tenascin-C.	Sulfhydryl Compounds	11-16	tenascin C	Homo sapiens	205-215
30625997-10	2019	Finally, NADP-ICDH activities were decreased both in a catalase2 mutant and in mutants affected in thiol reduction systems, suggesting a role of the thiol reduction systems to protect NADP-ICDH activities in planta.	Sulfhydryl Compounds	149-154	catalase 2	Arabidopsis thaliana	55-64
30417195-2	2019	In this work, we report a fluorescent molecular probe for assaying BChE activity based on thiol-triggered fluorescence enhancement via thiol-ene click reactions.	Sulfhydryl Compounds	90-95	butyrylcholinesterase	Homo sapiens	67-71
30417195-9	2019	This work demonstrates a design strategy of fluorescent probes lighted up by thiol-ene click reactions, reveals the main cause of thiol-triggered fluorescence enhancement by altering the radiative rate, and provides the first fluorometric assay of BChE based on rapid thiol-ene click reactions.	Sulfhydryl Compounds	77-82	butyrylcholinesterase	Homo sapiens	248-252
30401714-1	2019	Glutathione (GSH)/GSH reductase (GSR) and thioredoxin/thioredoxin reductase (TXNRD) are two major compensating thiol-dependent antioxidant pathways that maintain protein dithiol/disulfide balance.	Sulfhydryl Compounds	111-116	thioredoxin	Homo sapiens	42-53
30666186-0	2018	Light-Induced Thiol Oxidation of Recoverin Affects Rhodopsin Desensitization.	Sulfhydryl Compounds	14-19	recoverin	Homo sapiens	33-42
30666186-0	2018	Light-Induced Thiol Oxidation of Recoverin Affects Rhodopsin Desensitization.	Sulfhydryl Compounds	14-19	rhodopsin	Homo sapiens	51-60
30666186-7	2018	Histological data indicate that thiol oxidation of recoverin precedes apoptosis of photoreceptors.	Sulfhydryl Compounds	32-37	recoverin	Homo sapiens	51-60
30666186-11	2018	Overall, the intensity and duration of illumination of the retina affect thiol oxidation of recoverin likely contributing to propagation of the oxidative stress and photoreceptor damage.	Sulfhydryl Compounds	73-78	recoverin	Homo sapiens	92-101
30415064-7	2019	We further synthesized SrtA-sensitive peptide linker (i.e., KCLPRTGCK) for crosslinking with 8-arm PEG-norbornene (PEG8NB) via thiol-norbornene photocrosslinking.	Sulfhydryl Compounds	127-132	IGF2 antisense RNA	Homo sapiens	115-121
30401714-1	2019	Glutathione (GSH)/GSH reductase (GSR) and thioredoxin/thioredoxin reductase (TXNRD) are two major compensating thiol-dependent antioxidant pathways that maintain protein dithiol/disulfide balance.	Sulfhydryl Compounds	111-116	peroxiredoxin 5	Homo sapiens	54-75
31631785-5	2019	Furthermore, mutations that impaired the thiol reductase activity or disrupted the N-linked glycosylation, a posttranslational modification essential for its lysosomal localization, largely compromised GILT restriction of viral entry.	Sulfhydryl Compounds	41-46	IFI30 lysosomal thiol reductase	Homo sapiens	202-206
30389454-0	2019	Colorimetric detection of PCA3 in urine for prostate cancer diagnosis using thiol-labeled PCR primer and unmodified gold nanoparticles.	Sulfhydryl Compounds	76-81	prostate cancer associated 3	Homo sapiens	26-30
31069778-2	2019	Angiotensinogen is found in two distinct posttranslational forms in the plasma, an oxidized and a reduced (free thiol) form.	Sulfhydryl Compounds	112-117	angiotensinogen	Homo sapiens	0-15
30394289-7	2019	Modification of free thiol with N-ethylmaleimide revealed that Cys198 in CaMKIV is a target for S-oxidation.	Sulfhydryl Compounds	21-26	calcium/calmodulin dependent protein kinase IV	Homo sapiens	73-79
31069778-4	2019	We have developed novel ELISA assays to quantitate the levels of total and free thiol angiotensinogen allowing for calculation of the amount of oxidized angiotensinogen species.	Sulfhydryl Compounds	80-85	angiotensinogen	Homo sapiens	86-101
31288716-4	2019	A method to obtain selectivity for JAK3 over the other JAK family members, which has attracted more scientific attention recently, is the targeting of the active site cysteine residue, unique in JAK3 within the JAK family, with compounds containing electrophilic warheads which can form a covalent bond with the nucleophilic thiol of the cysteine residue.	Sulfhydryl Compounds	325-330	Janus kinase 3	Homo sapiens	35-39
31288716-4	2019	A method to obtain selectivity for JAK3 over the other JAK family members, which has attracted more scientific attention recently, is the targeting of the active site cysteine residue, unique in JAK3 within the JAK family, with compounds containing electrophilic warheads which can form a covalent bond with the nucleophilic thiol of the cysteine residue.	Sulfhydryl Compounds	325-330	Janus kinase 3	Homo sapiens	195-199
30465586-2	2018	This highly regioselective approach afforded C-3 functionalized products in excellent yield, and this methodology was found to be compatible with both aromatic and aliphatic thiols having electronic and steric divergence as well as diverse functional groups.	Sulfhydryl Compounds	174-180	complement C3	Homo sapiens	45-48
30284335-1	2019	Peroxiredoxins are thiol-dependent peroxidases that function in peroxide detoxification and H2 O2 induced signaling.	Sulfhydryl Compounds	19-24	peroxiredoxin 1	Homo sapiens	0-14
30284335-8	2019	The longer lifetime of PRDX2 sulfenic acid allows it to react with other protein thiols to translate the signal via an intermediate mixed disulfide (involving its peroxidatic cysteine), whereas PRDX1 continues the cycle forming disulfide involving its resolving cysteine to function as a redox relay.	Sulfhydryl Compounds	81-87	peroxiredoxin 2	Homo sapiens	23-28
30411617-3	2018	In the absence of Hg2+, the thiol-modified T-rich probe 1 spontaneously formed a hairpin structure by base pairing.	Sulfhydryl Compounds	28-33	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	18-21
30398845-9	2018	Calculated chemical properties as well as data from molecular orbital calculations, reactive molecular dynamics simulations, and intrinsic reaction coordinate modeling also supported the selectivity of 15d-PGJ2"s C9 toward PPARdelta"s Cys thiol.	Sulfhydryl Compounds	239-244	peroxisome proliferator activated receptor delta	Homo sapiens	223-232
30015030-5	2018	Because of stronger affinity between the thiol and Hg2+, over 90% fluorescence was recovered by adding 40 muM glutathione to CDs-Hg2+ system.	Sulfhydryl Compounds	41-46	latexin	Homo sapiens	106-109
30513914-0	2018	The Role of Cystinosin in the Intermediary Thiol Metabolism and Redox Homeostasis in Kidney Proximal Tubular Cells.	Sulfhydryl Compounds	43-48	cystinosin, lysosomal cystine transporter	Homo sapiens	12-22
30513914-3	2018	Because of the apparent involvement of cystinosin in the intermediary thiol metabolism, its discovery has fuelled investigations into its role in modulating cellular redox homeostasis.	Sulfhydryl Compounds	70-75	cystinosin, lysosomal cystine transporter	Homo sapiens	39-49
30513914-11	2018	Non-invasive techniques such as in vivo magnetic resonance imaging with the aid of systems biology approaches may provide invaluable mechanistic insights into the role of cystinosin in the essential intermediary thiol metabolism and in the overall regulation cellular redox homeostasis.	Sulfhydryl Compounds	212-217	cystinosin, lysosomal cystine transporter	Homo sapiens	171-181
30359716-6	2018	Src activation was based on interaction between thiol group of thiomers and cysteine-riched Src upstream membrane receptors, EGFR and IGFR.	Sulfhydryl Compounds	48-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
30390092-13	2018	Thus, astrocytic thiol supply increased neuronal resilience to various proteotoxic stressors by simultaneously attenuating cell death-related stress responses, and enhancing the recovery from proteotoxic stress through upregulation of NRF-1.	Sulfhydryl Compounds	17-22	nuclear respiratory factor 1	Homo sapiens	235-240
30315102-5	2018	By combining acid quenching and thiol alkylation, we stabilized and purified the complexes formed between endogenous PDIp and its target proteins from the mouse pancreas.	Sulfhydryl Compounds	32-37	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	117-121
30253188-9	2018	In the setting of oxidative stress (hydrogen peroxide)-mediated death of human retinal pigment epithelial cells as can occur in AMD, the free thiol form of CFH offers a protective function compared to the oxidised form.	Sulfhydryl Compounds	142-147	complement factor H	Homo sapiens	156-159
30253188-10	2018	We found for the first time using a novel ELISA system we have developed for free thiol CFH, that both redox forms of CFH are found in the human plasma.	Sulfhydryl Compounds	82-87	complement factor H	Homo sapiens	88-91
30253188-10	2018	We found for the first time using a novel ELISA system we have developed for free thiol CFH, that both redox forms of CFH are found in the human plasma.	Sulfhydryl Compounds	82-87	complement factor H	Homo sapiens	118-121
30792914-6	2018	Thiol marker was 0.34 +- 0.26 in NVD without and 0.26 +- 0.24 in NVD with Entonox, suggesting the lack of a statistically significant difference (p = 0.09).The FRAP results were 0.936 +- 0.696 in NVD without and 1.21 +- 0.89 in NVD with Entonox, suggesting the lack of a statistically significant difference (p = 0.06).	Sulfhydryl Compounds	0-5	mechanistic target of rapamycin kinase	Homo sapiens	160-164
31239850-9	2018	Only Native/total thiol*100 values are higher in patients who use insulin than those who do not.	Sulfhydryl Compounds	18-23	insulin	Homo sapiens	66-73
30262286-8	2018	Reactive species generation, lipid peroxidation and thiol depletion were also substantially increased in cells after exposure to SZ1.	Sulfhydryl Compounds	52-57	DLG2 antisense RNA 1	Homo sapiens	129-132
30315444-9	2018	But the increase in the serum E2 level as noted in the ELISA data with impairment in the hepatic estrogen sulfotransferase (SULT1E1) protein expression (immuno-blot data) were noticed with interfered hepatic free-thiols only in ENU and xenograft-E2 group compared to arsenic group.	Sulfhydryl Compounds	213-219	sulfotransferase family 1E member 1	Homo sapiens	97-122
30315444-9	2018	But the increase in the serum E2 level as noted in the ELISA data with impairment in the hepatic estrogen sulfotransferase (SULT1E1) protein expression (immuno-blot data) were noticed with interfered hepatic free-thiols only in ENU and xenograft-E2 group compared to arsenic group.	Sulfhydryl Compounds	213-219	sulfotransferase family 1E member 1	Homo sapiens	124-131
30315937-4	2018	The aim of this study was to identify constitutive interaction partners of Prx2 in Jurkat T-lymphoma cells, in which thiol protein oxidation occurs at low micromolar concentrations of H2O2.	Sulfhydryl Compounds	117-122	paired related homeobox 2	Homo sapiens	75-79
30538993-0	2018	Structural Basis for the Limited Response to Oxidative and Thiol-Conjugating Agents by Triosephosphate Isomerase From the Photosynthetic Bacteria Synechocystis.	Sulfhydryl Compounds	59-64	triosephosphate isomerase	Arabidopsis thaliana	87-112
30246912-2	2018	Peptide polymerization relies on tyrosinase oxidation of tyrosine residues to Dopaquinones, which rapidly form cysteinyldopa-moieties with free thiols from cysteine residues, thereby linking unimers and generating adhesive polymers.	Sulfhydryl Compounds	144-150	tyrosinase	Homo sapiens	33-43
30524244-2	2018	Recently, we have reported that protein disulfide isomerase (PDI) reduces disulfide bond (S-S) to free thiol (-SH) on NMDAR.	Sulfhydryl Compounds	103-108	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	32-59
30524244-2	2018	Recently, we have reported that protein disulfide isomerase (PDI) reduces disulfide bond (S-S) to free thiol (-SH) on NMDAR.	Sulfhydryl Compounds	103-108	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	61-64
30524244-6	2018	However, PDI knockdown effectively inhibited pilocarpine-induced acute seizures and spontaneous seizures in chronic epilepsy rats, accompanied by increasing the SNO-thiol-to-total thiol ratio on NMDAR due to diminishing the amounts of total thiols on GluN1 and GluN2A.	Sulfhydryl Compounds	165-170	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	9-12
30524244-6	2018	However, PDI knockdown effectively inhibited pilocarpine-induced acute seizures and spontaneous seizures in chronic epilepsy rats, accompanied by increasing the SNO-thiol-to-total thiol ratio on NMDAR due to diminishing the amounts of total thiols on GluN1 and GluN2A.	Sulfhydryl Compounds	180-185	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	9-12
30524244-6	2018	However, PDI knockdown effectively inhibited pilocarpine-induced acute seizures and spontaneous seizures in chronic epilepsy rats, accompanied by increasing the SNO-thiol-to-total thiol ratio on NMDAR due to diminishing the amounts of total thiols on GluN1 and GluN2A.	Sulfhydryl Compounds	241-247	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	9-12
30584462-6	2018	This suggests functions of Nrx in the oxidation of protein thiols.	Sulfhydryl Compounds	59-65	nucleoredoxin	Homo sapiens	27-30
30358983-0	2018	Tetrachlorobenzoquinone-Induced Nrf2 Confers Neuron-like PC12 Cells Resistance to Endoplasmic Reticulum Stress via Regulating Glutathione Synthesis and Protein Thiol Homeostasis.	Sulfhydryl Compounds	160-165	NFE2 like bZIP transcription factor 2	Rattus norvegicus	32-36
30358983-10	2018	Overall, our results analyzed the relationships between Nrf2 and ER stress in response to TCBQ and showed that activation of Nrf2-GSH played a protective role against TCBQ-induced ER stress-associated neurotoxicity via regulating GSH synthesis and protein thiol homeostasis.	Sulfhydryl Compounds	256-261	NFE2 like bZIP transcription factor 2	Rattus norvegicus	56-60
30358983-10	2018	Overall, our results analyzed the relationships between Nrf2 and ER stress in response to TCBQ and showed that activation of Nrf2-GSH played a protective role against TCBQ-induced ER stress-associated neurotoxicity via regulating GSH synthesis and protein thiol homeostasis.	Sulfhydryl Compounds	256-261	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-129
30403670-6	2018	There was a significant elevation in LPO, in conjunction with a significant decline in the enzymatic antioxidants superoxide dismutase, catalase, and glutathione peroxidase and the non-enzymatic antioxidants glutathione and thiols.	Sulfhydryl Compounds	224-230	lactoperoxidase	Rattus norvegicus	37-40
30415466-5	2018	Finally, CdS quantum dots (QDs) were introduced on the ITO in order to increase the PEC response of g-C3N4 based on the Cd-S binding between the QDs and thiol groups.	Sulfhydryl Compounds	153-158	CDP-diacylglycerol synthase 1	Homo sapiens	120-124
30423958-7	2018	Then, the addition of three thiol-containing amino acids (Cys, Hcy, GSH) to the quenched fluorescence solution with Hg2+ can restore the fluorescence, and the detection limits of the three biothiols (Cys, Hcy, GSH) are 0.133 muM, 0.086 muM, and 0.123 muM, respectively.	Sulfhydryl Compounds	28-33	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	116-119
30351107-7	2018	It is observed that formation of a thiazolidine ring from NAC occurs primarily in four steps, which involve proton abstraction from the thiol (SH) group of NAC and subsequent formation of an S-C bond by a nucleophilic attack of the C-S group on the protonated C-O-H group in NAC.	Sulfhydryl Compounds	136-141	X-linked Kx blood group	Homo sapiens	58-61
30351107-7	2018	It is observed that formation of a thiazolidine ring from NAC occurs primarily in four steps, which involve proton abstraction from the thiol (SH) group of NAC and subsequent formation of an S-C bond by a nucleophilic attack of the C-S group on the protonated C-O-H group in NAC.	Sulfhydryl Compounds	136-141	X-linked Kx blood group	Homo sapiens	156-159
30351107-7	2018	It is observed that formation of a thiazolidine ring from NAC occurs primarily in four steps, which involve proton abstraction from the thiol (SH) group of NAC and subsequent formation of an S-C bond by a nucleophilic attack of the C-S group on the protonated C-O-H group in NAC.	Sulfhydryl Compounds	136-141	X-linked Kx blood group	Homo sapiens	156-159
30228182-2	2018	These effects are thought to be mediated by alterations in the redox state of critical thiols in the IP3R, but this has not been directly demonstrated in intact cells.	Sulfhydryl Compounds	87-93	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	101-105
30228182-11	2018	To our knowledge, this study is the first that has used proteomic methods to assess the redox state of individual thiols in IP3R in intact cells.	Sulfhydryl Compounds	114-120	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	124-128
32254875-3	2018	The thiol-capped ELPs were used to prepare functionalized gold nanoparticles (GNPs), which were found to undergo thermally-triggered reversible aggregation at 40  C. The peptide conformation and nanoparticle aggregation behaviour of the ELP-GNPs in aqueous solution were investigated by transmission electron microscopy (TEM), circular dichroism (CD) and UV-vis spectroscopy.	Sulfhydryl Compounds	4-9	nuclear receptor subfamily 5 group A member 1	Homo sapiens	17-20
30257333-8	2018	On the other hand, there was a reduction in GPx activity and total thiol levels after IL-17 A administration.	Sulfhydryl Compounds	67-72	interleukin 17A	Mus musculus	86-93
29920414-0	2018	The control of the adsorption of bovine serum albumin on mercaptan-modified gold thin films investigated by SERS spectroscopy.	Sulfhydryl Compounds	57-66	albumin	Homo sapiens	40-53
29920414-1	2018	Nanostructured gold thin films were built from deposition of colloidal gold nanoparticles on silanized glass slides, and used to study the adsorption of bovine serum albumin (BSA) after chemical treatment of gold surface with the mercaptans 2-mercaptoethanol, 3-mercaptoproprionic acid, 1,3-propanedithiol and 1-propanethiol.	Sulfhydryl Compounds	230-240	albumin	Homo sapiens	160-173
30353352-4	2018	PDI/Trp showed fluorescence quenching in the presence of Hg2+ and the fluorescence was recovered after addition of biological thiols (cysteine, homocysteine and glutathione).	Sulfhydryl Compounds	126-132	peptidyl arginine deiminase 1	Homo sapiens	0-3
30257364-4	2018	Elevated levels of PDE-5", arginase, AChE, ADA and ACE activities and MDA were observed in PAR-induced rats with concomitant decrease in non-protein thiol levels when compared to the NC group.	Sulfhydryl Compounds	149-154	plasminogen activator, urokinase receptor	Rattus norvegicus	91-94
29596885-10	2018	Inhibition of TrxR2, by hindering the activity of Trx2 and Prx3, increases the mitochondrial concentration of reactive oxygen species and shifts the thiol redox state toward a more oxidized condition.	Sulfhydryl Compounds	149-154	thioredoxin reductase 2	Homo sapiens	14-19
30278242-5	2018	Metabolism of arsenite to dimethylarsinate (DMAV) by arsenite-3-methyltransferase (As3MT) promotes clearance, but also generates reactive trivalent intermediates that bind extensively to cellular thiols.	Sulfhydryl Compounds	196-202	arsenite methyltransferase	Mus musculus	83-88
29775743-3	2018	Due to the catalytic redox cycle, low concentrations of methylselenol, a postulated active metabolite of selenium, react with the tumor-promoting lipid hydroperoxide bound to PKC to form methylseleninic acid (MSA), which selectively reacts with thiol residues present within the vicinity of the PKC catalytic domain to inactivate it.	Sulfhydryl Compounds	245-250	proline rich transmembrane protein 2	Homo sapiens	175-178
29775743-8	2018	Due to a high-affinity binding of thioredoxin to the PKC catalytic domain, this thiol oxidation is explicitly reversed by thioredoxin reductase (TXNRD), a selenoprotein.	Sulfhydryl Compounds	80-85	thioredoxin	Homo sapiens	34-45
29775743-8	2018	Due to a high-affinity binding of thioredoxin to the PKC catalytic domain, this thiol oxidation is explicitly reversed by thioredoxin reductase (TXNRD), a selenoprotein.	Sulfhydryl Compounds	80-85	proline rich transmembrane protein 2	Homo sapiens	53-56
29775743-8	2018	Due to a high-affinity binding of thioredoxin to the PKC catalytic domain, this thiol oxidation is explicitly reversed by thioredoxin reductase (TXNRD), a selenoprotein.	Sulfhydryl Compounds	80-85	peroxiredoxin 5	Homo sapiens	122-143
29775743-8	2018	Due to a high-affinity binding of thioredoxin to the PKC catalytic domain, this thiol oxidation is explicitly reversed by thioredoxin reductase (TXNRD), a selenoprotein.	Sulfhydryl Compounds	80-85	peroxiredoxin 5	Homo sapiens	145-150
30192996-3	2018	SERS studies with aromatic thiols further support the slow surface modification kinetics observed by fluorescence spectroscopy.	Sulfhydryl Compounds	27-33	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-4
30207066-7	2018	Thiols within the catalytic motif of PDI are essential for its role in thrombosis.	Sulfhydryl Compounds	0-6	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	37-40
30207066-11	2018	Methods and results The role of endogenous NO in PDI activity was evaluated by incubating endothelium with an NO scavenger, which resulted in exposure of free thiols, increased thiol isomerase activity, and enhanced thrombin generation on the cell membrane.	Sulfhydryl Compounds	159-165	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	49-52
30207066-11	2018	Methods and results The role of endogenous NO in PDI activity was evaluated by incubating endothelium with an NO scavenger, which resulted in exposure of free thiols, increased thiol isomerase activity, and enhanced thrombin generation on the cell membrane.	Sulfhydryl Compounds	159-164	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	49-52
30345904-6	2018	One Sudanese family of Arab descent residing in Saudi Arabia harbored a homozygous c.464A&gt;G, p.Asn155Ser mutation in PYROXD1, a gene recently reported in association with myofibrillar myopathy and whose protein product reduces thiol residues.	Sulfhydryl Compounds	230-235	pyridine nucleotide-disulphide oxidoreductase domain 1	Mus musculus	120-127
29885581-3	2018	Bioconjugation mechanism was applied by conjugating anti-TDP 43 with N-succinimidyl S-acetylthioacetate (SATA) producing a thiol-linked anti-TDP 43, which was used to directly link with gold electrode surface, minimizing the preparation steps for biosensor fabrication and simplifying the biosensor surface.	Sulfhydryl Compounds	123-128	TAR DNA binding protein	Homo sapiens	57-63
30260223-1	2018	An operationally simple sodium iodide-mediated C-S and C-Se bond formation protocol involving substituted 4-quinolone and thiols/diselenide to generate different ArS/ArSe-substituted 4-quinolone derivatives in excellent yields was developed.	Sulfhydryl Compounds	122-128	RIEG2	Homo sapiens	162-165
30260223-1	2018	An operationally simple sodium iodide-mediated C-S and C-Se bond formation protocol involving substituted 4-quinolone and thiols/diselenide to generate different ArS/ArSe-substituted 4-quinolone derivatives in excellent yields was developed.	Sulfhydryl Compounds	122-128	arylsulfatase L	Homo sapiens	166-170
30165045-4	2018	We successfully applied this assay to investigate the effects of thiol-reactive compounds and divalent cations on TGase2 kinase by determining the half maximal inhibitory concentrations (IC50).	Sulfhydryl Compounds	65-70	transglutaminase 2	Homo sapiens	114-120
30165045-5	2018	Thiol-reactive compounds inhibited TGase2 kinase activity in a concentration-dependent manner, with IC50 values ranging from 0.125 to 5.550 mM.	Sulfhydryl Compounds	0-5	transglutaminase 2	Homo sapiens	35-41
30057300-0	2018	Role of Thiol Reactivity for Targeting Mutant p53.	Sulfhydryl Compounds	8-13	tumor protein p53	Homo sapiens	46-49
30057300-2	2018	Recent studies have identified several mutant p53-reactivating compounds that target thiol groups in mutant p53.	Sulfhydryl Compounds	85-90	tumor protein p53	Homo sapiens	46-49
30057300-2	2018	Recent studies have identified several mutant p53-reactivating compounds that target thiol groups in mutant p53.	Sulfhydryl Compounds	85-90	tumor protein p53	Homo sapiens	108-111
30057300-4	2018	Analysis of the National Cancer Institute database revealed that Michael acceptors show the highest selectivity for mutant p53-expressing cells among analyzed thiol-reactive compounds.	Sulfhydryl Compounds	159-164	tumor protein p53	Homo sapiens	123-126
30057300-6	2018	Moreover, mild thiol reactivity, often coupled with combined chemical functional groups, such as in imines, aldehydes, and primary alcohols, can stimulate mutant p53 refolding.	Sulfhydryl Compounds	15-20	tumor protein p53	Homo sapiens	162-165
30148350-0	2018	Highly Sensitive Membraneless Fructose Biosensor Based on Fructose Dehydrogenase Immobilized onto Aryl Thiol Modified Highly Porous Gold Electrode: Characterization and Application in Food Samples.	Sulfhydryl Compounds	103-108	aldehyde dehydrogenase 1 family member L1	Homo sapiens	58-80
29885581-3	2018	Bioconjugation mechanism was applied by conjugating anti-TDP 43 with N-succinimidyl S-acetylthioacetate (SATA) producing a thiol-linked anti-TDP 43, which was used to directly link with gold electrode surface, minimizing the preparation steps for biosensor fabrication and simplifying the biosensor surface.	Sulfhydryl Compounds	123-128	TAR DNA binding protein	Homo sapiens	141-147
30138815-6	2018	These results revealed the potential for peptide degradation via the cleavage of disulfide cyclization bonds to form free thiols when using one of these C18 cartridges.	Sulfhydryl Compounds	122-128	Bardet-Biedl syndrome 9	Homo sapiens	153-156
30311601-9	2018	The results show that the 2-CysPrx serves as electron sink in the thiol network important to oxidize reductively activated proteins and represents the missing link in the reversal of thioredoxin-dependent regulation.	Sulfhydryl Compounds	66-71	thioredoxin	Homo sapiens	183-194
30173384-1	2018	Mammalian delta-aminolevulinate dehydratase (delta-ALA-D) is a metalloenzyme, which requires Zn(II) and reduced thiol groups for catalytic activity, and is an important molecular target for the widespread environmental toxic metals.	Sulfhydryl Compounds	112-117	aminolevulinate dehydratase	Homo sapiens	10-43
30318520-5	2018	We also show a correlation between the decrease of reduced thiols with a poorer clinical outcome of CLL patients bearing mutant TP53 gene.	Sulfhydryl Compounds	59-65	tumor protein p53	Homo sapiens	128-132
30173384-1	2018	Mammalian delta-aminolevulinate dehydratase (delta-ALA-D) is a metalloenzyme, which requires Zn(II) and reduced thiol groups for catalytic activity, and is an important molecular target for the widespread environmental toxic metals.	Sulfhydryl Compounds	112-117	aminolevulinate dehydratase	Homo sapiens	45-56
30030891-5	2018	We here review how TF is switched between its role in coagulation and cell signaling through thiol-disulfide exchange reactions in the context of physiologically relevant lipid microdomains.	Sulfhydryl Compounds	93-98	coagulation factor III, tissue factor	Homo sapiens	19-21
29787950-6	2018	The resulting large-sized pore silica nanoparticles, especially those modified with thiol group, exhibited the high Bcl-2-converting peptide-loading efficiency of over 40%.	Sulfhydryl Compounds	84-89	BCL2 apoptosis regulator	Homo sapiens	116-121
29488135-6	2018	Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the thioredoxin (TRX) system, a major cellular thiol-reducing and antioxidant system.	Sulfhydryl Compounds	117-122	thioredoxin interacting protein	Homo sapiens	0-31
30291946-5	2018	It is well-documented that the thiol redox homeostasis of schistosomes is entirely based on a single enzyme named thioredoxin-glutathione reductase (TGR).	Sulfhydryl Compounds	31-36	thioredoxin reductase 3	Homo sapiens	114-147
30291946-5	2018	It is well-documented that the thiol redox homeostasis of schistosomes is entirely based on a single enzyme named thioredoxin-glutathione reductase (TGR).	Sulfhydryl Compounds	31-36	thioredoxin reductase 3	Homo sapiens	149-152
29488135-6	2018	Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the thioredoxin (TRX) system, a major cellular thiol-reducing and antioxidant system.	Sulfhydryl Compounds	117-122	thioredoxin interacting protein	Homo sapiens	33-38
29488135-6	2018	Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the thioredoxin (TRX) system, a major cellular thiol-reducing and antioxidant system.	Sulfhydryl Compounds	117-122	thioredoxin	Homo sapiens	74-85
29488135-6	2018	Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the thioredoxin (TRX) system, a major cellular thiol-reducing and antioxidant system.	Sulfhydryl Compounds	117-122	thioredoxin	Homo sapiens	87-90
30098457-9	2018	In the presence of hydrogen peroxide, GRPEL2 forms dimers through intermolecular disulfide bonds in which Cys87 is the thiol switch.	Sulfhydryl Compounds	119-124	GrpE like 2, mitochondrial	Homo sapiens	38-44
30429709-0	2018	Dynamic thiol/disulphide homeostasis in vitiligo patients.	Sulfhydryl Compounds	8-13	VAMAS6	Homo sapiens	40-48
30429709-2	2018	Aim: To examine the thiol/disulphide balance in vitiligo patients and to compare the results with a healthy control group.	Sulfhydryl Compounds	20-25	VAMAS6	Homo sapiens	48-56
30429709-9	2018	In this study, we investigated in vitiligo patients whether thiol/disulphide balance is a new oxidative stress marker.	Sulfhydryl Compounds	60-65	VAMAS6	Homo sapiens	34-42
29860091-3	2018	Also, this review focuses on the development of electrochemical label-free immunosensor for SOD1 and the recent advances in biosensing assay methods based on their catalytic and biological functions with various substrates including reactive oxygen species (superoxide anion radical, hydrogen peroxide), nitric oxide metabolites (nitrite, nitrate) and thiols using thiol oxidase activity.	Sulfhydryl Compounds	352-358	superoxide dismutase 1	Homo sapiens	92-96
30429709-13	2018	We are of the opinion that new investigations to determine serum levels of thiol/disulphide may shed light on the possible roles of these molecules in vitiligo.	Sulfhydryl Compounds	75-80	VAMAS6	Homo sapiens	151-159
30025197-2	2018	The prochelator GGTDTC requires activation by gamma-glutamyl transferase (GGT) to release the metal chelator diethyldithiocarbamate from a linker that masks its thiol reactivity and metal binding properties.	Sulfhydryl Compounds	161-166	gamma-glutamyltransferase 1	Homo sapiens	46-72
30025197-2	2018	The prochelator GGTDTC requires activation by gamma-glutamyl transferase (GGT) to release the metal chelator diethyldithiocarbamate from a linker that masks its thiol reactivity and metal binding properties.	Sulfhydryl Compounds	161-166	gamma-glutamyltransferase 1	Homo sapiens	16-19
30017915-4	2018	This mechanism of kinase inhibition results in compounds that can target PLK1 with high selectivity, while avoiding issues with irreversible covalent binding and interaction with other thiol-containing molecules in the cell.	Sulfhydryl Compounds	185-190	polo like kinase 1	Homo sapiens	73-77
30148635-3	2018	We target an isolated aromatic thiol (thiobenzonitrile, TBN) as a prototypical molecular system.	Sulfhydryl Compounds	31-36	TATA-box binding protein associated factor 8	Homo sapiens	56-59
30148952-3	2018	By integrated with the thiol-induced inhibition of PDA formation, an ingenious inorganic-organic hybrid tongue-mimic sensor array is thus unveiled for noninvasive pattern recognition of thiols in biofluids in a TRL-RET-reversed "turn on" format toward healthcare monitoring.	Sulfhydryl Compounds	23-28	ret proto-oncogene	Homo sapiens	215-218
30148952-3	2018	By integrated with the thiol-induced inhibition of PDA formation, an ingenious inorganic-organic hybrid tongue-mimic sensor array is thus unveiled for noninvasive pattern recognition of thiols in biofluids in a TRL-RET-reversed "turn on" format toward healthcare monitoring.	Sulfhydryl Compounds	186-192	ret proto-oncogene	Homo sapiens	215-218
30156819-4	2018	Oxidation of thiols by chloramine-T promotes fibronectin (FN) adsorption and fibroblast cell adhesion, whereas the reduction by tris(2-carboxyethyl)phosphine reverses these effects, leading to low FN adsorption and little cell adhesion and spreading.	Sulfhydryl Compounds	13-19	fibronectin 1	Homo sapiens	45-56
30156819-4	2018	Oxidation of thiols by chloramine-T promotes fibronectin (FN) adsorption and fibroblast cell adhesion, whereas the reduction by tris(2-carboxyethyl)phosphine reverses these effects, leading to low FN adsorption and little cell adhesion and spreading.	Sulfhydryl Compounds	13-19	fibronectin 1	Homo sapiens	58-60
30156819-4	2018	Oxidation of thiols by chloramine-T promotes fibronectin (FN) adsorption and fibroblast cell adhesion, whereas the reduction by tris(2-carboxyethyl)phosphine reverses these effects, leading to low FN adsorption and little cell adhesion and spreading.	Sulfhydryl Compounds	13-19	fibronectin 1	Homo sapiens	197-199
30202003-4	2018	Instead of using crosslinking technique and surface immobilization of antibody, we applied a novel method for biosensor fabrication, using S-Acetylmercaptosuccinic anhydride (SAMSA) to modify the Anti-GPC-1 producing a thiol-linked Anti-GPC-1.	Sulfhydryl Compounds	219-224	glypican 1	Homo sapiens	201-206
30056268-2	2018	Albumin is susceptible to numerous post-translational modifications and particularly related to its free thiol group at Cys34 which is the main circulating scavenger of reactive oxygen species.	Sulfhydryl Compounds	105-110	albumin	Homo sapiens	0-7
30218010-0	2018	Two Tau binding sites on tubulin revealed by thiol-disulfide exchanges.	Sulfhydryl Compounds	45-50	microtubule associated protein tau	Homo sapiens	4-7
30202003-5	2018	The thiol-linked Anti-GPC-1 was then directly formed a single-layer antibody layer on the gold biosensor, minimizing the biosensor preparation steps significantly.	Sulfhydryl Compounds	4-9	glypican 1	Homo sapiens	22-27
29978532-0	2018	Solid-Phase Thiol-Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist.	Sulfhydryl Compounds	12-17	calcitonin related polypeptide alpha	Homo sapiens	75-79
30021839-3	2018	In this study, we have identified a thiol-dependent substrate interaction between EDEM1 and the alpha1-antitrypsin ER-associated protein degradation (ERAD) clients Z and NHK, specifically through the single Cys residue on Z/NHK (Cys256), required for binding under stringent detergent conditions.	Sulfhydryl Compounds	36-41	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	82-87
30021839-5	2018	About four reactive thiols on EDEM1 were identified and were not directly responsible for the observed redox-sensitive binding by EDEM1.	Sulfhydryl Compounds	20-26	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	30-35
30021839-6	2018	Moreover, a protein construct comprising the EDEM1 MLD had thiol-dependent binding properties along with its active glycan-trimming activities.	Sulfhydryl Compounds	59-64	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	45-50
29627323-5	2018	Inhibition of ASK1 kinase activity, either by specific ASK1 inhibitor, NQDI1 or by thiol antioxidants reduces human amylin-evoked ASK1 and JNK activation and consequently human amylin toxicity in rat insulinoma Rin-m5F cells and human islets.	Sulfhydryl Compounds	83-88	islet amyloid polypeptide	Homo sapiens	116-122
29959487-3	2018	Subsequently, the substrate DNA1 was adsorbed onto the surfaces of the gold nanoparticles via thiol-gold bonds, so that the complementary guanine-rich DNA2 could be hybridized to the gold electrode in sequence.	Sulfhydryl Compounds	94-99	DNA replication helicase/nuclease 2	Homo sapiens	151-155
29627323-5	2018	Inhibition of ASK1 kinase activity, either by specific ASK1 inhibitor, NQDI1 or by thiol antioxidants reduces human amylin-evoked ASK1 and JNK activation and consequently human amylin toxicity in rat insulinoma Rin-m5F cells and human islets.	Sulfhydryl Compounds	83-88	mitogen-activated protein kinase 8	Homo sapiens	139-142
29627323-5	2018	Inhibition of ASK1 kinase activity, either by specific ASK1 inhibitor, NQDI1 or by thiol antioxidants reduces human amylin-evoked ASK1 and JNK activation and consequently human amylin toxicity in rat insulinoma Rin-m5F cells and human islets.	Sulfhydryl Compounds	83-88	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	14-18
29627323-5	2018	Inhibition of ASK1 kinase activity, either by specific ASK1 inhibitor, NQDI1 or by thiol antioxidants reduces human amylin-evoked ASK1 and JNK activation and consequently human amylin toxicity in rat insulinoma Rin-m5F cells and human islets.	Sulfhydryl Compounds	83-88	islet amyloid polypeptide	Homo sapiens	177-183
30028086-1	2018	Human serum albumin (HSA) is characterized by 17 disulfides and by only one unpaired cysteine (Cys34 ), which can be free in the reduced albumin or linked as a mixed disulfide with cysteine, or in minor amount with other natural thiols, in the oxidized albumin.	Sulfhydryl Compounds	229-235	albumin	Homo sapiens	6-19
29890337-7	2018	Pretreatment with the thiol reducing agents, N-acetylcysteine (NAC) or dithiothreitol (DTT), attenuated Nrf2 activation and HO-1 expression.	Sulfhydryl Compounds	22-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	104-108
29604397-4	2018	beta2-GPI also undergoes dynamic posttranslational modification between oxidized and free thiol forms.	Sulfhydryl Compounds	90-95	apolipoprotein H	Homo sapiens	0-9
30055731-3	2018	There are no studies in literature on the association between autosomal recessive non-syndromic hearing loss(ARNSHL) including GJB2 and non-GJB2 mutations and thiol-disulphide balance.	Sulfhydryl Compounds	159-164	gap junction protein beta 2	Homo sapiens	127-131
29890337-7	2018	Pretreatment with the thiol reducing agents, N-acetylcysteine (NAC) or dithiothreitol (DTT), attenuated Nrf2 activation and HO-1 expression.	Sulfhydryl Compounds	22-27	heme oxygenase 1	Rattus norvegicus	124-128
29890337-9	2018	These results suggest that ECN may directly interact with Kelch-like ECH-associated protein 1 (Keap1) and modify critical cysteine thiols present in the proteins responsible for Nrf2-mediated upregulation of HO-1.	Sulfhydryl Compounds	131-137	NFE2 like bZIP transcription factor 2	Rattus norvegicus	178-182
29890337-9	2018	These results suggest that ECN may directly interact with Kelch-like ECH-associated protein 1 (Keap1) and modify critical cysteine thiols present in the proteins responsible for Nrf2-mediated upregulation of HO-1.	Sulfhydryl Compounds	131-137	heme oxygenase 1	Rattus norvegicus	208-212
29710586-0	2018	Efficient removal of Cd2+ and Pb2+ from aqueous solution with amino- and thiol-functionalized activated carbon: Isotherm and kinetics modeling.	Sulfhydryl Compounds	73-78	CD2 molecule	Homo sapiens	21-24
30104347-0	2018	Thioredoxin-like2/2-Cys peroxiredoxin redox cascade supports oxidative thiol modulation in chloroplasts.	Sulfhydryl Compounds	71-76	thioredoxin H-type 1	Arabidopsis thaliana	0-11
29778001-6	2018	Here, as an example, thiol-terminated aptamers were immobilized onto the patchy gold part as a signal probe to detect carcinoembryonic antigen (CEA).	Sulfhydryl Compounds	21-26	CEA cell adhesion molecule 3	Homo sapiens	118-142
29778001-6	2018	Here, as an example, thiol-terminated aptamers were immobilized onto the patchy gold part as a signal probe to detect carcinoembryonic antigen (CEA).	Sulfhydryl Compounds	21-26	CEA cell adhesion molecule 3	Homo sapiens	144-147
30087968-2	2018	The PDI-HQ-Pb2+ complex was further used to develop a fluorescent NIR ensemble for the detection of thiols.	Sulfhydryl Compounds	100-106	peptidyl arginine deiminase 1	Homo sapiens	4-7
30960878-3	2018	The thiophenol group would be involved with disulfide bonds between the polymer chains and siRNA modified with free thiols (thiol-siRNA) to form and pi-pi interactions between the pendent aromatic groups and coprostane ring of the bile acid.	Sulfhydryl Compounds	116-122	glucosidase beta 2	Mus musculus	231-240
30960878-3	2018	The thiophenol group would be involved with disulfide bonds between the polymer chains and siRNA modified with free thiols (thiol-siRNA) to form and pi-pi interactions between the pendent aromatic groups and coprostane ring of the bile acid.	Sulfhydryl Compounds	116-121	glucosidase beta 2	Mus musculus	231-240
29729206-0	2018	Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates.	Sulfhydryl Compounds	51-56	albumin	Homo sapiens	72-79
30140002-3	2018	The thioredoxin (Trx) and glutaredoxin (Grx) systems are important as antioxidants for maintaining cellular redox balance and providing electrons for thiol-dependent reactions like those catalyzed by ribonucleotide reductase and peroxiredoxins (Prxs).	Sulfhydryl Compounds	150-155	thioredoxin	Homo sapiens	4-15
30140002-3	2018	The thioredoxin (Trx) and glutaredoxin (Grx) systems are important as antioxidants for maintaining cellular redox balance and providing electrons for thiol-dependent reactions like those catalyzed by ribonucleotide reductase and peroxiredoxins (Prxs).	Sulfhydryl Compounds	150-155	thioredoxin	Homo sapiens	17-20
30140002-3	2018	The thioredoxin (Trx) and glutaredoxin (Grx) systems are important as antioxidants for maintaining cellular redox balance and providing electrons for thiol-dependent reactions like those catalyzed by ribonucleotide reductase and peroxiredoxins (Prxs).	Sulfhydryl Compounds	150-155	glutaredoxin	Homo sapiens	26-38
30140002-3	2018	The thioredoxin (Trx) and glutaredoxin (Grx) systems are important as antioxidants for maintaining cellular redox balance and providing electrons for thiol-dependent reactions like those catalyzed by ribonucleotide reductase and peroxiredoxins (Prxs).	Sulfhydryl Compounds	150-155	glutaredoxin	Homo sapiens	40-43
30043021-0	2018	Modulating the GSH/Trx selectivity of a fluorogenic disulfide-based thiol sensor to reveal diminished GSH levels under ER stress.	Sulfhydryl Compounds	68-73	thioredoxin	Homo sapiens	19-22
29898414-8	2018	Furthermore, the binding of biotin-tagged BR to Kelch-like ECH-associated protein 1 (KEAP1)-a biological electrophile sensor-was prevented by pretreatment with BR or a thiol compound, but was not by pretreatment with BV.	Sulfhydryl Compounds	168-173	kelch like ECH associated protein 1	Homo sapiens	48-83
29898414-8	2018	Furthermore, the binding of biotin-tagged BR to Kelch-like ECH-associated protein 1 (KEAP1)-a biological electrophile sensor-was prevented by pretreatment with BR or a thiol compound, but was not by pretreatment with BV.	Sulfhydryl Compounds	168-173	kelch like ECH associated protein 1	Homo sapiens	85-90
30089863-4	2018	Using single-molecule force-clamp spectroscopy, here we show that mechanical force promotes the thermodynamically disfavored SN2 cleavage of an individual protein disulfide bond by poor nucleophilic organic thiols.	Sulfhydryl Compounds	207-213	solute carrier family 38 member 5	Homo sapiens	125-128
30094692-5	2018	A capture thrombin-binding aptamer 2 (TBA-2; a 15-mer) carrying a 3"-terminal thiol group was self-assembled onto the surface of the gold electrode.	Sulfhydryl Compounds	78-83	coagulation factor II, thrombin	Homo sapiens	10-18
29808942-3	2018	The BET surface areas for the Mannich products are reduced from that of UiO-66-NH2 , but the compounds show enhanced selectivity for adsorption of CO2 over N2 at 273 K. The thiol-containing MOFs adsorb mercury(II) ions from aqueous solution, removing up to 99 %.	Sulfhydryl Compounds	173-178	delta/notch like EGF repeat containing	Homo sapiens	4-7
29923039-5	2018	Cd2+ presumably inactivates IDH due to its high affinity for thiols, leading to a covalent enzyme modification.	Sulfhydryl Compounds	61-67	CD2 molecule	Homo sapiens	0-3
29923039-5	2018	Cd2+ presumably inactivates IDH due to its high affinity for thiols, leading to a covalent enzyme modification.	Sulfhydryl Compounds	61-67	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-31
29923039-9	2018	Glutathione, a cellular sulphydryl reductant, has a moderate affinity for Cd2+, allowing IDH to be activated with residual Cd2+, unlike dithiothreitol, which has a much higher affinity.	Sulfhydryl Compounds	24-34	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	89-92
30042429-1	2018	Thiol-dependent enzymes, including the thioredoxin (Trx) and glutathione (GSH) systems, have recently been found as promising bactericidal targets in multidrug-resistant (MDR) bacteria.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	39-50
30256204-3	2018	The aim of this prospective study was to evaluate the role of oxidative stress, using native thiol/disulfide (SH/SS) homeostasis as a novel indicator, in the etiology of BPPV.	Sulfhydryl Compounds	93-98	benign paroxysmal positional vertigo	Homo sapiens	170-174
30415238-0	2018	Effect of thiol antioxidants on lipopolysaccharide-induced cyclooxygenase-2 expression in pulmonary epithelial cells.	Sulfhydryl Compounds	10-15	prostaglandin-endoperoxide synthase 2	Homo sapiens	59-75
30415238-8	2018	Pretreatment of thiol antioxidants GSH and NAC reduced ROS levels and attenuated the increase in ROS, the activation of NF-kappaB, AP-1, and STAT-3, and the expression of COX-2 in LPS-treated A549 cells.	Sulfhydryl Compounds	16-21	nuclear factor kappa B subunit 1	Homo sapiens	120-129
30415238-8	2018	Pretreatment of thiol antioxidants GSH and NAC reduced ROS levels and attenuated the increase in ROS, the activation of NF-kappaB, AP-1, and STAT-3, and the expression of COX-2 in LPS-treated A549 cells.	Sulfhydryl Compounds	16-21	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-135
30415238-8	2018	Pretreatment of thiol antioxidants GSH and NAC reduced ROS levels and attenuated the increase in ROS, the activation of NF-kappaB, AP-1, and STAT-3, and the expression of COX-2 in LPS-treated A549 cells.	Sulfhydryl Compounds	16-21	signal transducer and activator of transcription 3	Homo sapiens	141-147
30415238-8	2018	Pretreatment of thiol antioxidants GSH and NAC reduced ROS levels and attenuated the increase in ROS, the activation of NF-kappaB, AP-1, and STAT-3, and the expression of COX-2 in LPS-treated A549 cells.	Sulfhydryl Compounds	16-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	171-176
30256204-5	2018	RESULTS: Patients with BPPV initially had significantly lower native SH levels and significantly lower SH/total thiol (TT) ratios, as well as significantly higher SS/SH and SS/TT ratios, than the healthy controls.	Sulfhydryl Compounds	112-117	benign paroxysmal positional vertigo	Homo sapiens	23-27
30042429-1	2018	Thiol-dependent enzymes, including the thioredoxin (Trx) and glutathione (GSH) systems, have recently been found as promising bactericidal targets in multidrug-resistant (MDR) bacteria.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	52-55
29714059-0	2018	Blocking the Thiol at Cysteine-322 Destabilizes Tau Protein and Prevents Its Oligomer Formation.	Sulfhydryl Compounds	13-18	microtubule associated protein tau	Homo sapiens	48-51
30031898-8	2018	In silico and Inductively Coupled Plasma Mass Spectrometry studies revealed the interaction of Arsenic to the Cx43 preferably occurs through surface exposed cysteines, thereby capping the thiol groups that form disulfide bonds in the tertiary structure.	Sulfhydryl Compounds	188-193	gap junction protein alpha 1	Homo sapiens	110-114
29714059-3	2018	Here we uncover a critical role of the free thiol at Cys-322 in determining tau stability.	Sulfhydryl Compounds	44-49	microtubule associated protein tau	Homo sapiens	76-79
29714059-4	2018	We found that the application of thiol-blocking agents like NEM or MMTS blocks this thiol, by which it destabilizes tau protein and prevents its oligomer formation.	Sulfhydryl Compounds	33-38	microtubule associated protein tau	Homo sapiens	116-119
29714059-4	2018	We found that the application of thiol-blocking agents like NEM or MMTS blocks this thiol, by which it destabilizes tau protein and prevents its oligomer formation.	Sulfhydryl Compounds	84-89	microtubule associated protein tau	Homo sapiens	116-119
30001196-1	2018	BACKGROUND: Three low molecular weight thiols are synthesized by Mycobacterium tuberculosis (M.tb), namely ergothioneine (ERG), mycothiol (MSH) and gamma-glutamylcysteine (GGC).	Sulfhydryl Compounds	39-45	msh homeobox 2	Homo sapiens	139-142
29684906-8	2018	The HILIC method was successfully applied for the analysis of commercially available samples of pharmaceutically active thiols such as captopril, N-acetyl-l-cysteine (NAC) and cysteine.	Sulfhydryl Compounds	120-126	X-linked Kx blood group	Homo sapiens	167-170
30001196-12	2018	This study therefore suggests that the most effective strategy to target thiol biosynthesis for anti-tuberculosis drug development would be the simultaneous inhibition of the biosynthesis of ERG, MSH and GGC.	Sulfhydryl Compounds	73-78	msh homeobox 2	Homo sapiens	196-199
29752269-11	2018	The results indicate that the capability to resist oxidative stress is required for virulence of A. alternataIMPORTANCE The thioredoxin and glutaredoxin systems are important thiol antioxidant systems in cells, and knowledge of these two systems in the plant-pathogenic fungus A. alternata is useful for finding new strategies to reduce the virulence of this pathogen.	Sulfhydryl Compounds	175-180	CC77DRAFT_723006	Alternaria alternata	124-135
29916707-4	2018	The addition of cysteine, a low-molecular-mass free thiol, resulted in increased aggregation of both Ca-sat and Ca-dep alpha-LA.	Sulfhydryl Compounds	52-57	lactalbumin alpha	Homo sapiens	119-127
30288233-1	2018	We describe here two novel antibody-drug conjugates loaded with the HDAC inhibitor ST7612AA1 (IC50 equal to 0.07 muM on NCI-H460 cells), a thiol-based molecule with a moderate toxicity in vivo.	Sulfhydryl Compounds	139-144	histone deacetylase 9	Homo sapiens	68-72
29752269-11	2018	The results indicate that the capability to resist oxidative stress is required for virulence of A. alternataIMPORTANCE The thioredoxin and glutaredoxin systems are important thiol antioxidant systems in cells, and knowledge of these two systems in the plant-pathogenic fungus A. alternata is useful for finding new strategies to reduce the virulence of this pathogen.	Sulfhydryl Compounds	175-180	CC77DRAFT_929808	Alternaria alternata	140-152
30037569-6	2018	Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents.	Sulfhydryl Compounds	188-193	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	33-36
29728915-3	2018	Isolated human and bovine erythrocytic CAII and CAIV can convert nitrite to nitrous acid (HONO) and its anhydride N2O3 which, in the presence of thiols (RSH), are further converted to S-nitrosothiols (RSNO) and NO.	Sulfhydryl Compounds	145-151	carbonic anhydrase 2	Bos taurus	39-43
29728915-3	2018	Isolated human and bovine erythrocytic CAII and CAIV can convert nitrite to nitrous acid (HONO) and its anhydride N2O3 which, in the presence of thiols (RSH), are further converted to S-nitrosothiols (RSNO) and NO.	Sulfhydryl Compounds	145-151	carbonic anhydrase 4	Bos taurus	48-52
29594387-6	2018	In this review article, we discuss targets of redox-dependent thiol modifications that are known or expected to be involved in the regulation of EV release, namely redox-sensitive calcium channels, N-ethylmaleimide sensitive factor, protein disulfide isomerase, phospholipid flippases, actin filaments, calpains and cell surface-exposed thiols.	Sulfhydryl Compounds	62-67	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	198-231
30037569-6	2018	Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents.	Sulfhydryl Compounds	17-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	33-36
30037569-6	2018	Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents.	Sulfhydryl Compounds	17-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	110-113
29773183-8	2018	However, the increased-[Zn2+]i could induce marked activation in ATP-sensitive K+-channel currents, IKATP, depending on low cellular ATP and thiol-oxidation levels of these channels.	Sulfhydryl Compounds	141-146	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	100-105
30037569-6	2018	Furthermore, the thiol groups of p65 were modified by CAPE, and the inhibitory effects of CAPE and DBL on the p65 phosphorylation and nitrite production were reversed by pretreatment with thiol-containing reagents.	Sulfhydryl Compounds	188-193	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	110-113
30037569-7	2018	These results suggest that CAPE has strong inhibitory effects on the NF-kappaB activation that are associated with the modification of thiol groups and phosphorylation of p65.	Sulfhydryl Compounds	135-140	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
29545647-6	2018	Conversely, hydrogen sulfide (H2S), a sulfhydryl-containing gasotransmitter, confers anti-inflammatory effects through decreasing [Cl-]i via activation of cystic fibrosis transmembrane conductance regulator (CFTR).	Sulfhydryl Compounds	38-48	CF transmembrane conductance regulator	Homo sapiens	155-206
29782701-2	2018	In order to achieve this without compromising network properties, multifunctional linear poly(glycidol) acrylate (PG-Acr) is synthesized and utilized as crosslinker for hydrogel formation with thiol-functionalized hyaluronic acid via Michael-type addition.	Sulfhydryl Compounds	193-198	acrosin	Homo sapiens	117-120
29669129-7	2018	These results suggest that AtOPT6 is likely to be involved in transporting GSH, PCs and Cd complexed with these thiols into sink organs.	Sulfhydryl Compounds	112-118	oligopeptide transporter 1	Arabidopsis thaliana	27-33
28527631-0	2018	The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration.	Sulfhydryl Compounds	4-9	mitofusin 2	Homo sapiens	25-36
28527631-4	2018	Mitochondrial hyperfusion represents an adaptive stress response that confers transient protection by increasing mitochondrial ATP production but how this depends on the thiol switch C684 in MFN2 has not been investigated.	Sulfhydryl Compounds	170-175	mitofusin 2	Homo sapiens	191-195
29717933-0	2018	The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.	Sulfhydryl Compounds	25-30	kelch like ECH associated protein 1	Homo sapiens	4-9
29717933-0	2018	The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.	Sulfhydryl Compounds	25-30	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
29717933-2	2018	KEAP1 acts as a cysteine thiol-rich sensor of redox insults, whereas NRF2 is a transcription factor that robustly transduces chemical signals to regulate a battery of cytoprotective genes.	Sulfhydryl Compounds	25-30	kelch like ECH associated protein 1	Homo sapiens	0-5
29553725-1	2018	Two-cysteine peroxiredoxins (Prx) have a three-step catalytic cycle consisting of (1) reduction of peroxide and formation of sulfenic acid on the enzyme, (2) condensation of the sulfenic acid with a thiol to form disulfide, also known as resolution, and (3) reduction of the disulfide by a reductant protein.	Sulfhydryl Compounds	199-204	peroxiredoxin 1	Homo sapiens	13-27
29550515-4	2018	When treated to MCF-7 cells, 15d-PGJ2 bound to PTEN, and this was abolished in the presence of the thiol-reducing agent dithiothreitol.	Sulfhydryl Compounds	99-104	phosphatase and tensin homolog	Homo sapiens	47-51
29967247-2	2018	The overall thiol pool is the resultant of several individual pools of small compounds (e.g. cysteine), peptides (e.g. glutathione), and thiol proteins (e.g. thioredoxin (Trx)), which are not in equilibrium and present specific oxidized/reduced ratios.	Sulfhydryl Compounds	12-17	thioredoxin	Homo sapiens	158-169
29967247-2	2018	The overall thiol pool is the resultant of several individual pools of small compounds (e.g. cysteine), peptides (e.g. glutathione), and thiol proteins (e.g. thioredoxin (Trx)), which are not in equilibrium and present specific oxidized/reduced ratios.	Sulfhydryl Compounds	12-17	thioredoxin	Homo sapiens	171-174
29792672-10	2018	Mycothiol (MSH) and ergothioneine (EGT), two small-molecule thiols that are known for their redox-relevant roles in protection against various endogenous and exogenous stresses, function through two unusual S-glycosylations to mediate an eight-carbon aminosugar transfer, activation, and modification during the molecular assembly and tailoring processes in lincosamide antibiotic biosynthesis.	Sulfhydryl Compounds	60-66	msh homeobox 2	Homo sapiens	11-14
29851341-4	2018	Using the thiol pair of Cu/Zn-superoxide dismutase (SOD1), we demonstrated that cyclic disulfides, including the drug/nutritional supplement lipoic acid, efficiently cross-linked thiol pairs but avoided dead-end modifications.	Sulfhydryl Compounds	10-15	superoxide dismutase 1	Homo sapiens	52-56
29851341-4	2018	Using the thiol pair of Cu/Zn-superoxide dismutase (SOD1), we demonstrated that cyclic disulfides, including the drug/nutritional supplement lipoic acid, efficiently cross-linked thiol pairs but avoided dead-end modifications.	Sulfhydryl Compounds	179-184	superoxide dismutase 1	Homo sapiens	52-56
29792672-11	2018	Related intermediates include an MSH S-conjugate, mercapturic acid, and a thiomethyl product, which are reminiscent of intermediates found in thiol-mediated detoxification metabolism.	Sulfhydryl Compounds	142-147	msh homeobox 2	Homo sapiens	33-36
29553725-2	2018	By following changes in protein fluorescence, we have studied the pH dependence of reaction 2 in human peroxiredoxins 1, 2, and 5 and in Salmonella typhimurium AhpC and obtained rate constants for the reaction and p Ka values of the thiol and sulfenic acid involved for each system.	Sulfhydryl Compounds	233-238	peroxiredoxin 1	Homo sapiens	103-129
29792672-12	2018	In these biosynthetic pathways, "old" protein folds can result in "new" enzymatic activity, such as the DinB-2 fold protein for thiol exchange between EGT and MSH, the gamma-glutamyltranspeptidase homologue for C-C bond cleavage, and the pyridoxal-5"-phosphate-dependent enzyme for diverse S-functionalization, generating interest in how nature develops remarkably diverse biochemical functions using a limited range of protein scaffolds.	Sulfhydryl Compounds	128-133	msh homeobox 2	Homo sapiens	159-162
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	high mobility group box 1	Mus musculus	0-25
29605485-7	2018	Our results showed a significant elevation in TBARS level after administration of Abeta causing mitochondrial ROS generation, swelling, outer membrane damage, cytochrome C release and also lower thiol, FRAP, and MMP levels.	Sulfhydryl Compounds	195-200	amyloid beta precursor protein	Rattus norvegicus	82-87
29532356-3	2018	Herein, we hypothesized that the maleimide group-containing 5-FU prodrug (EMC-5-FU) could improve the intestinal mucoadhesion because the maleimide end group can covalently target thiol residues of mucin glycoprotein covering the intestinal enterocytes.	Sulfhydryl Compounds	180-185	solute carrier family 13 member 2	Rattus norvegicus	198-203
29859088-10	2018	CONCLUSIONS: Both Tpx1 and OxyR contain thiol switches, with very high reactivity towards peroxides.	Sulfhydryl Compounds	40-45	cysteine rich secretory protein 2	Homo sapiens	18-22
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	high mobility group box 1	Mus musculus	27-32
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	high mobility group box 1	Mus musculus	208-213
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	high mobility group box 1	Mus musculus	208-213
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	high mobility group box 1	Mus musculus	208-213
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	high mobility group box 1	Mus musculus	208-213
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	advanced glycosylation end product-specific receptor	Mus musculus	342-346
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	toll-like receptor 4	Mus musculus	352-372
29196860-1	2018	High mobility group box 1 (HMGB1), a nuclear protein, once released into the extracellular space under pathological conditions, plays a pronociceptive role in redox-dependent distinct active forms, all-thiol HMGB1 (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), that accelerate nociception through the receptor for advanced glycation endproducts (RAGE) and Toll-like receptor 4 (TLR4), respectively.	Sulfhydryl Compounds	202-207	toll-like receptor 4	Mus musculus	374-378
29683468-0	2018	Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols.	Sulfhydryl Compounds	104-110	hepatocyte nuclear factor 4 alpha	Homo sapiens	16-19
29861445-5	2018	Here, the insoluble paclitaxel becomes incorporated into the hydrophobic core of the self-assemblies formed in an aqueous environment (256 nm), while the cytochrome C attaches irreversibly onto the hybrid nanoparticle surface via gold-thiol dative covalent binding.	Sulfhydryl Compounds	235-240	cytochrome c, somatic	Homo sapiens	154-166
29622725-2	2018	We combined SLAM-seq [thiol(SH)-linked alkylation for the metabolic sequencing of RNA], a method for direct quantification of newly synthesized messenger RNAs (mRNAs), with pharmacological and chemical-genetic perturbation in order to define regulatory functions of two transcriptional hubs in cancer, BRD4 and MYC, and to interrogate direct responses to BET bromodomain inhibitors (BETis).	Sulfhydryl Compounds	22-27	signaling lymphocytic activation molecule family member 1	Homo sapiens	12-16
29744490-3	2018	According to MP2/6-311++G(2d,p) calculations, the thiol tautomer should be higher in energy by 62.5 kJ mol-1.	Sulfhydryl Compounds	50-55	tryptase pseudogene 1	Homo sapiens	13-16
29743079-5	2018	In the current study, Jurkat T cell lines expressing Tat and its deletion mutants were used to determine the effect of Tat on the thiol proteome in the presence and absence of SMX-HA revealing drug-dependent changes in the disulfide proteome in HIV infected cells.	Sulfhydryl Compounds	130-135	tyrosine aminotransferase	Homo sapiens	119-122
29743079-7	2018	RESULTS: Redox 2D gel electrophoresis demonstrated that untreated, Tat-expressing cells contain a number of proteins with oxidized thiols.	Sulfhydryl Compounds	131-137	tyrosine aminotransferase	Homo sapiens	67-70
29683468-1	2018	Two "turn on" TCF-based fluorescence probes were developed for the detection of biological thiols (TCF-GSH and TCFCl-GSH).	Sulfhydryl Compounds	91-97	hepatocyte nuclear factor 4 alpha	Homo sapiens	14-17
29683468-1	2018	Two "turn on" TCF-based fluorescence probes were developed for the detection of biological thiols (TCF-GSH and TCFCl-GSH).	Sulfhydryl Compounds	91-97	hepatocyte nuclear factor 4 alpha	Homo sapiens	99-102
29156406-4	2018	The nanohybrids conjugated with streptavidin and biotinylated signal probes were used as the tracer labels, target miR-122 was sandwiched between the tracer labels and thiol-terminated capture probes inserted in MCH monolayer on the gold nanoparticles-functionalized nitrogen-doped graphene sheets (AuNPs@N-G) modified electrode.	Sulfhydryl Compounds	168-173	microRNA 122	Homo sapiens	115-122
29751548-5	2018	Compound 1"s thiol sulfur formed hydrogen bonding interactions with Gly154 and Tyr308, respectively, and made it bound more closely to HDAC2.	Sulfhydryl Compounds	13-18	histone deacetylase 2	Homo sapiens	135-140
29127898-3	2018	A thiol terminated DNA aptamer with affinity for HER2 was used to prepare the bio-recognition layer via self-assembly on interdigitated gold surfaces.	Sulfhydryl Compounds	2-7	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-53
29369431-5	2018	To render a particular target molecule accessible for PELDOR, it can be engineered to contain only one or two surface-exposed cysteine residues, which can be efficiently spin-labelled using thiol-reactive nitroxide compounds.	Sulfhydryl Compounds	190-195	spindlin 1	Homo sapiens	170-174
29760703-7	2018	Moreover, H2S donor directly inhibited the activity of purified AAT protein, which was reversed by a thiol reductant DTT.	Sulfhydryl Compounds	101-106	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	64-67
29542320-6	2018	Using VAC for the MOF film growth on gold surfaces modified with thiol SAMs and on a bare silicon surface yielded oriented MOF films, rendering the VAC process robust toward chemical surface variations.	Sulfhydryl Compounds	65-70	methionine adenosyltransferase 1A	Homo sapiens	71-75
29938191-4	2018	To improve the therapy efficiency as a PTT agent, the MCP NPs are further modified with functional polyethylene glycol (PEG) and thiol terminal cyclic arginine-glycine-aspartic acid peptide, respectively: the first one is to increase the stability, biocompatibility, and blood circulation time of MCP NPs in vivo; the second one is to increase the tumor accumulation of MCP-PEG NPs and improve their therapeutic efficiency as photothermal agent.	Sulfhydryl Compounds	129-134	CD46 molecule	Homo sapiens	54-57
29448054-9	2018	We also assessed RAGE"s effect on redox regulation and report that RAGE knockdown attenuated oxidant production, decreased protein oxidation, and increased reduced thiol pools.	Sulfhydryl Compounds	164-169	advanced glycosylation end product-specific receptor	Rattus norvegicus	67-71
28870850-4	2018	All of these patients with major bleeding presented with hypoprothrombinemia secondary to hypovitaminosis K. This adverse event may be due to inhibition of vitamin K epoxide reductase and/or gamma-glutamyl-carboxylase by the 2-methyl-1,2,3-thiadiazol-5-thiol group of cefazolin.	Sulfhydryl Compounds	253-258	vitamin K epoxide reductase complex subunit 1	Homo sapiens	156-183
29521093-0	2018	Au-Se-Bond-Based Nanoprobe for Imaging MMP-2 in Tumor Cells under a High-Thiol Environment.	Sulfhydryl Compounds	73-78	matrix metallopeptidase 2	Homo sapiens	39-44
28870850-4	2018	All of these patients with major bleeding presented with hypoprothrombinemia secondary to hypovitaminosis K. This adverse event may be due to inhibition of vitamin K epoxide reductase and/or gamma-glutamyl-carboxylase by the 2-methyl-1,2,3-thiadiazol-5-thiol group of cefazolin.	Sulfhydryl Compounds	253-258	gamma-glutamyl carboxylase	Homo sapiens	191-217
28888895-4	2018	Our previous studies demonstrated that an unpaired thiol in the cytoplasmic tail of GPVI undergoes rapid oxidation to form GPVI homodimers in response to ligand binding, indicating an oxidative submembranous environment in platelets after GPVI stimulation.	Sulfhydryl Compounds	51-56	glycoprotein VI platelet	Homo sapiens	84-88
29106077-1	2018	Previous studies have shown that the mammalian delta-aminolevulinic acid dehydratase (delta-ALAD) is inhibited by selenides and selenoxides, which can involve thiol oxidation.	Sulfhydryl Compounds	159-164	aminolevulinate dehydratase	Homo sapiens	47-84
29106077-1	2018	Previous studies have shown that the mammalian delta-aminolevulinic acid dehydratase (delta-ALAD) is inhibited by selenides and selenoxides, which can involve thiol oxidation.	Sulfhydryl Compounds	159-164	aminolevulinate dehydratase	Homo sapiens	86-96
29355776-2	2018	Since small G protein RhoA contains cysteine residues in the GTP-binding domain which is critical for its function, modification these thiols may alter RhoA activity and lead to changes in the downstream signaling such as myosin light chain phosphorylation.	Sulfhydryl Compounds	135-141	ras homolog family member A	Homo sapiens	22-26
29355776-2	2018	Since small G protein RhoA contains cysteine residues in the GTP-binding domain which is critical for its function, modification these thiols may alter RhoA activity and lead to changes in the downstream signaling such as myosin light chain phosphorylation.	Sulfhydryl Compounds	135-141	ras homolog family member A	Homo sapiens	152-156
29355776-2	2018	Since small G protein RhoA contains cysteine residues in the GTP-binding domain which is critical for its function, modification these thiols may alter RhoA activity and lead to changes in the downstream signaling such as myosin light chain phosphorylation.	Sulfhydryl Compounds	135-141	myosin heavy chain 14	Homo sapiens	222-228
29355776-5	2018	CSNO was shown to lead to RhoA nitrosylation and RhoA thiol oxidation status was found to be consistent with loss of its activity.	Sulfhydryl Compounds	54-59	ras homolog family member A	Homo sapiens	49-53
29040960-4	2018	The free thiol at Cys34 on human serum albumin (HSA) is highly stable, has a long retention and possess a high reactivity for RSS.	Sulfhydryl Compounds	9-14	albumin	Mus musculus	33-46
29358221-1	2018	According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols.	Sulfhydryl Compounds	232-238	aldehyde dehydrogenase 2 family member	Homo sapiens	41-65
29358221-1	2018	According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular nitrate tolerance and explains the dependence of this reaction on added thiols.	Sulfhydryl Compounds	232-238	aldehyde dehydrogenase 2 family member	Homo sapiens	67-72
29358221-4	2018	In addition to the thiol-reversible oxidation of ALDH2, thiol-refractive inactivation was observed, particularly under high-turnover conditions.	Sulfhydryl Compounds	19-24	aldehyde dehydrogenase 2 family member	Homo sapiens	49-54
29358221-7	2018	On a longer time scale, mechanism-based, thiol-refractive irreversible inactivation of ALDH2, and possibly depletion of the endogenous reductant, will render blood vessels tolerant to GTN.	Sulfhydryl Compounds	41-46	aldehyde dehydrogenase 2 family member	Homo sapiens	87-92
28888895-4	2018	Our previous studies demonstrated that an unpaired thiol in the cytoplasmic tail of GPVI undergoes rapid oxidation to form GPVI homodimers in response to ligand binding, indicating an oxidative submembranous environment in platelets after GPVI stimulation.	Sulfhydryl Compounds	51-56	glycoprotein VI platelet	Homo sapiens	123-127
28888895-4	2018	Our previous studies demonstrated that an unpaired thiol in the cytoplasmic tail of GPVI undergoes rapid oxidation to form GPVI homodimers in response to ligand binding, indicating an oxidative submembranous environment in platelets after GPVI stimulation.	Sulfhydryl Compounds	51-56	glycoprotein VI platelet	Homo sapiens	123-127
29578059-4	2018	TRPV1, TRPA1 and TRPC can respond to electrophilic fatty acids because they have ankyrin-like repeats in their N terminus that are rich in cysteine residues that react with electrophiles and other thiol modifying species.	Sulfhydryl Compounds	197-202	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
29578059-4	2018	TRPV1, TRPA1 and TRPC can respond to electrophilic fatty acids because they have ankyrin-like repeats in their N terminus that are rich in cysteine residues that react with electrophiles and other thiol modifying species.	Sulfhydryl Compounds	197-202	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	7-12
32625823-0	2018	Scientific Opinion on Flavouring Group Evaluation 74, Revision 4 (FGE.74Rev4): Consideration of aliphatic sulphides and thiols evaluated by JECFA (53rd and 61st meeting) structurally related to aliphatic and alicyclic mono-, di-, tri- and polysulphides with or without additional oxygenated functional groups from chemical group 20 evaluated by EFSA in FGE.08Rev5.	Sulfhydryl Compounds	120-126	sulfatase modifying factor 1	Homo sapiens	66-69
29563864-6	2018	Causative for alpha-Syn-induced neurodegeneration are mitochondrial thiol oxidation and activation of caspases downstream of mitochondrial outer membrane permeabilization, leading to apoptosis-like cell death execution with some unusual aspects.	Sulfhydryl Compounds	68-73	synuclein alpha	Rattus norvegicus	14-23
29253750-1	2018	A novel water-compatible surface molecularly imprinted thiol-functionalized titanium dioxide (TiO2) material (CMIP-coated TiO2) was prepared in water, using 2, 4-dinitrophenol (2, 4-DNP) as template molecule and o-phenylenediamine (OPDA) as both functional monomer and cross-linker.	Sulfhydryl Compounds	55-60	c-Maf inducing protein	Homo sapiens	110-114
29172434-4	2018	Various approaches to MBL inhibitors are described; among others, the promising motif of a zinc coordinating thiol moiety is very popular.	Sulfhydryl Compounds	109-114	mannose-binding lectin family member 3, pseudogene	Homo sapiens	22-25
29172434-5	2018	Nevertheless, since the first report of a thiol-based MBL inhibitor (thiomandelic acid) in 2001, no steps in development of thiol based MBL inhibitors were reported that go beyond clinical isolate testing.	Sulfhydryl Compounds	42-47	mannose-binding lectin family member 3, pseudogene	Homo sapiens	54-57
29172434-6	2018	In this study, we report on the synthesis and biochemical characterization of thiol-based MBL inhibitors and highlight the challenges behind the development of thiol-based compounds, which exhibit good in vitro activity toward a broad spectrum of MBLs, selectivity against human off-targets, and reasonable activity against clinical isolates.	Sulfhydryl Compounds	78-83	mannose-binding lectin family member 3, pseudogene	Homo sapiens	90-93
29172434-6	2018	In this study, we report on the synthesis and biochemical characterization of thiol-based MBL inhibitors and highlight the challenges behind the development of thiol-based compounds, which exhibit good in vitro activity toward a broad spectrum of MBLs, selectivity against human off-targets, and reasonable activity against clinical isolates.	Sulfhydryl Compounds	160-165	mannose-binding lectin family member 3, pseudogene	Homo sapiens	90-93
29329420-7	2018	The intracellular glutathione levels were reduced in Bcl-xL-overexpressing Chang-L cells treated with DOX/PDTC, and DOX/PDTC-induced paraptosis was effectively blocked by pretreatment with thiol-antioxidants, but not by non-thiol antioxidants.	Sulfhydryl Compounds	189-194	BCL2 like 1	Homo sapiens	53-59
29329420-7	2018	The intracellular glutathione levels were reduced in Bcl-xL-overexpressing Chang-L cells treated with DOX/PDTC, and DOX/PDTC-induced paraptosis was effectively blocked by pretreatment with thiol-antioxidants, but not by non-thiol antioxidants.	Sulfhydryl Compounds	224-229	BCL2 like 1	Homo sapiens	53-59
29329420-8	2018	Collectively, our results suggest that disruption of thiol homeostasis may critically contribute to DOX/PDTC-induced paraptosis in Bcl-xL-overexpressing cells.	Sulfhydryl Compounds	53-58	BCL2 like 1	Homo sapiens	131-137
29293453-7	2018	When the endothelial cells adhere to fibrinogen or fibronectin, PDI and alphaVbeta3 gain free thiol groups.	Sulfhydryl Compounds	94-99	fibrinogen beta chain	Homo sapiens	37-47
29779107-2	2018	Coimmobilization of BuChE with the thiol group indicator 5,5"-dithiobis(2-nitrobenzoic) acid did not reduce the activity of BuChE, which allowed us to simplify the procedure and reduce the time of analysis of organophosphorus pesticides.	Sulfhydryl Compounds	35-40	butyrylcholinesterase	Homo sapiens	20-25
29431026-4	2018	Mechanistic studies on the nitroglycerin bioactivation process revealed that during bioconversion of nitroglycerin and in the presence of reactive oxygen and nitrogen species the active site thiols of ALDH-2 are oxidized and the enzyme activity is lost.	Sulfhydryl Compounds	191-197	aldehyde dehydrogenase 2 family member	Homo sapiens	201-207
29293453-7	2018	When the endothelial cells adhere to fibrinogen or fibronectin, PDI and alphaVbeta3 gain free thiol groups.	Sulfhydryl Compounds	94-99	fibronectin 1	Homo sapiens	51-62
29293453-7	2018	When the endothelial cells adhere to fibrinogen or fibronectin, PDI and alphaVbeta3 gain free thiol groups.	Sulfhydryl Compounds	94-99	prolyl 4-hydroxylase subunit beta	Homo sapiens	64-67
29264659-5	2018	Native Grx5 could be reconstituted with all of the glutathione analogs used, as well as other thiol ligands, such as DTT or L-cysteine, by in vitro chemical reconstitution, and the holo proteins were found to transfer [2Fe-2S] cluster to apo ferredoxin 1 at comparable rates.	Sulfhydryl Compounds	94-99	glutaredoxin 5	Homo sapiens	7-11
29410996-0	2018	Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems.	Sulfhydryl Compounds	14-19	thioredoxin	Homo sapiens	61-72
29400693-6	2018	EPO catalyzed oxidation of thiocyanate and bromide by H2O2 to generate oxidants that crosslink cysteine thiol groups and stiffen thiolated hydrogels.	Sulfhydryl Compounds	104-109	eosinophil peroxidase	Homo sapiens	0-3
29410996-10	2018	Collectively, these results demonstrate that metal ions are major players in regulating the Trx and Grx systems-mediated cellular redox processes and thus, provide an opportunity to understand the functions of metal ions in thiol metabolism dysfunction-related diseases.	Sulfhydryl Compounds	224-229	thioredoxin	Homo sapiens	92-95
29410996-10	2018	Collectively, these results demonstrate that metal ions are major players in regulating the Trx and Grx systems-mediated cellular redox processes and thus, provide an opportunity to understand the functions of metal ions in thiol metabolism dysfunction-related diseases.	Sulfhydryl Compounds	224-229	glutaredoxin	Homo sapiens	100-103
29420254-8	2018	This involves an initial sulfenylation of the active site thiol followed by the formation of an intrachain disulfide with a resolving thiol group and completed by the reduction of this disulfide by a thioredoxin-like protein to regenerate the active site thiol.	Sulfhydryl Compounds	58-63	thioredoxin	Homo sapiens	200-211
29420254-8	2018	This involves an initial sulfenylation of the active site thiol followed by the formation of an intrachain disulfide with a resolving thiol group and completed by the reduction of this disulfide by a thioredoxin-like protein to regenerate the active site thiol.	Sulfhydryl Compounds	134-139	thioredoxin	Homo sapiens	200-211
29420254-8	2018	This involves an initial sulfenylation of the active site thiol followed by the formation of an intrachain disulfide with a resolving thiol group and completed by the reduction of this disulfide by a thioredoxin-like protein to regenerate the active site thiol.	Sulfhydryl Compounds	134-139	thioredoxin	Homo sapiens	200-211
29372915-2	2018	The human CFTR has two functionally active thiol groups for gating regulation by chemical modification.	Sulfhydryl Compounds	43-48	CF transmembrane conductance regulator	Homo sapiens	10-14
29410996-0	2018	Modulation of thiol-dependent redox system by metal ions via thioredoxin and glutaredoxin systems.	Sulfhydryl Compounds	14-19	glutaredoxin	Homo sapiens	77-89
28301954-6	2018	S-bacillithiolation of OhrR, MetE, and glyceraldehyde-3-phosphate dehydrogenase (Gap) functions, analogous to S-glutathionylation, as both a redox-regulatory device and in thiol protection under oxidative stress.	Sulfhydryl Compounds	9-14	AT695_RS09095	Staphylococcus aureus	39-79
29410996-3	2018	Mammalian TrxRs are selenoproteins; the thiols and selenols in the active site of these enzymes confer the thioredoxin system to work as soft bases, which have a high affinity with soft acids, including numerous metal ions.	Sulfhydryl Compounds	40-46	thioredoxin	Homo sapiens	107-118
28301954-6	2018	S-bacillithiolation of OhrR, MetE, and glyceraldehyde-3-phosphate dehydrogenase (Gap) functions, analogous to S-glutathionylation, as both a redox-regulatory device and in thiol protection under oxidative stress.	Sulfhydryl Compounds	9-14	AT695_RS09095	Staphylococcus aureus	81-84
29349898-0	2018	Helenalin Analogues Targeting NF-kappaB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles.	Sulfhydryl Compounds	45-50	nuclear factor kappa B subunit 1	Homo sapiens	30-39
28372502-1	2018	SIGNIFICANCE: Mycothiol (MSH, AcCys-GlcN-Ins) is the main low-molecular weight (LMW) thiol of most Actinomycetes, including the human pathogen Mycobacterium tuberculosis that affects millions of people worldwide.	Sulfhydryl Compounds	18-23	msh homeobox 2	Homo sapiens	25-28
29271657-2	2018	We report how application of in silico fragment-based molecular design employing thiol-mediated metal anchorage leads to potent MBL inhibitors.	Sulfhydryl Compounds	81-86	mannose-binding lectin family member 3, pseudogene	Homo sapiens	128-131
29439404-6	2018	At the molecular level, RyR2 channels from HFD-fed mice had substantially fewer free thiol residues, suggesting that redox modifications were responsible for the higher activity.	Sulfhydryl Compounds	85-90	ryanodine receptor 2, cardiac	Mus musculus	24-28
29422028-1	2018	BACKGROUND: Peroxiredoxins are ubiquitous thiol-dependent peroxidases that represent a major antioxidant defense in both prokaryotic cells and eukaryotic organisms.	Sulfhydryl Compounds	42-47	peroxiredoxin 1	Gallus gallus	12-26
29261301-3	2018	The currently available inhibitors of Trx1 and Grx1 are thiol-reactive electrophiles or disulfides that may suffer from low selectivity because of their thiol reactivity.	Sulfhydryl Compounds	56-61	thioredoxin	Homo sapiens	38-42
29261301-3	2018	The currently available inhibitors of Trx1 and Grx1 are thiol-reactive electrophiles or disulfides that may suffer from low selectivity because of their thiol reactivity.	Sulfhydryl Compounds	56-61	glutaredoxin	Homo sapiens	47-51
29261301-3	2018	The currently available inhibitors of Trx1 and Grx1 are thiol-reactive electrophiles or disulfides that may suffer from low selectivity because of their thiol reactivity.	Sulfhydryl Compounds	153-158	thioredoxin	Homo sapiens	38-42
29298486-2	2018	Herein, we report a redox-controlled fluorescence nanoswtich based on reversible disulfide bonds, and further develop a fluorometric assay of BChE via thiol-triggered disaggregation-induced emission.	Sulfhydryl Compounds	151-156	butyrylcholinesterase	Homo sapiens	142-146
29261301-3	2018	The currently available inhibitors of Trx1 and Grx1 are thiol-reactive electrophiles or disulfides that may suffer from low selectivity because of their thiol reactivity.	Sulfhydryl Compounds	153-158	glutaredoxin	Homo sapiens	47-51
29298486-6	2018	The specific thiol-triggered disaggregation-induced emission enables us to assay BChE activity in a fluorescence turn-on and real-time way using butyrylthiocholine iodide as the substrate.	Sulfhydryl Compounds	13-18	butyrylcholinesterase	Homo sapiens	81-85
29388568-7	2018	Using a single-step nanoprecipitation method, salinomycin-loaded lipid-polymer nanoparticles (SA-NPs) were prepared, then CD20-SA-NPs were obtained through conjugation of thiolated anti-CD20 aptamers to SA-NPs via a maleimide-thiol reaction.	Sulfhydryl Compounds	171-176	keratin 20	Homo sapiens	122-126
29273564-13	2018	Our data, suggest that Asc-s and ionizing radiation induced cell cycle arrest and apoptosis by perturbing redox balance through irreversible complexes of thiols with Asc-s, disturbed mitochondrial membrane permeability and activation of caspase-3 in EL4 cells.	Sulfhydryl Compounds	154-160	steroid sulfatase	Mus musculus	23-26
29273564-5	2018	Further it also significantly decreased GSH/GSSG ratio due to binding of Asc-s with thiols.	Sulfhydryl Compounds	84-90	steroid sulfatase	Mus musculus	73-76
29273564-6	2018	The increase in oxidative stress induced by Asc-s and radiation treatment was abrogated by thiol antioxidants in EL4 cells.	Sulfhydryl Compounds	91-96	steroid sulfatase	Mus musculus	44-47
29273564-13	2018	Our data, suggest that Asc-s and ionizing radiation induced cell cycle arrest and apoptosis by perturbing redox balance through irreversible complexes of thiols with Asc-s, disturbed mitochondrial membrane permeability and activation of caspase-3 in EL4 cells.	Sulfhydryl Compounds	154-160	steroid sulfatase	Mus musculus	166-169
28840318-3	2018	Second, PGRP simultaneously induces oxidative, thiol, and metal stress responses in bacteria, which individually are bacteriostatic, but in combination are bactericidal.	Sulfhydryl Compounds	47-52	peptidoglycan recognition protein 1	Homo sapiens	8-12
28840318-4	2018	Third, PGRP induces oxidative, thiol, and metal stress responses in bacteria through three independent pathways.	Sulfhydryl Compounds	31-36	peptidoglycan recognition protein 1	Homo sapiens	7-11
29277598-7	2018	Rap1 deletion lowered cellular thiol-redox status and diminished activities of thiol-redox enzymes, thioredoxin 1 and glutaredoxin 1.	Sulfhydryl Compounds	31-36	telomeric repeat binding factor 2, interacting protein	Mus musculus	0-4
28868943-10	2018	TAC and thiol groups were negatively correlated with TNF-alpha.	Sulfhydryl Compounds	8-13	tumor necrosis factor	Homo sapiens	53-62
29277598-7	2018	Rap1 deletion lowered cellular thiol-redox status and diminished activities of thiol-redox enzymes, thioredoxin 1 and glutaredoxin 1.	Sulfhydryl Compounds	79-84	telomeric repeat binding factor 2, interacting protein	Mus musculus	0-4
29675245-1	2018	The ligation of sterically demanding peptidyl sites such as those involving Val-Val and Val-Pro linkages has proven to be extremely challenging with conventional NCL methods that rely on exogenous thiol additives.	Sulfhydryl Compounds	197-202	nucleolin	Homo sapiens	162-165
29191937-6	2018	Limited proteolysis, kinetic simulations, and MS analyses confirmed that peroxynitrite preferentially oxidizes the redox-active Cys residues of PDI to the corresponding sulfenic acids, which reacted with the resolving thiols at the active sites to produce disulfides (i.e. Cys53-Cys56 and Cys397-Cys400).	Sulfhydryl Compounds	218-224	prolyl 4-hydroxylase subunit beta	Homo sapiens	144-147
29203246-0	2018	The role of Protein Disulfide Isomerase and thiol bonds modifications in activation of integrin subunit alpha11.	Sulfhydryl Compounds	44-49	integrin subunit alpha 11	Homo sapiens	87-111
30966139-8	2018	Thus, the improved mucoadhesion could be due to a Michael-type addition reaction between the nanoparticles and thiol groups present in mucin glycoprotein, in addition to entanglements and hydrogen bonding.	Sulfhydryl Compounds	111-116	LOC100508689	Homo sapiens	135-140
29178528-0	2018	Nanoscale Chemical Imaging of Reversible Photoisomerization of an Azobenzene-Thiol Self-Assembled Monolayer by Tip-Enhanced Raman Spectroscopy.	Sulfhydryl Compounds	77-82	TOR signaling pathway regulator	Homo sapiens	111-114
29178528-3	2018	Herein, the photoisomerization of a self-assembled monolayer of azobenzene-thiol molecules on a Au surface was investigated using scanning tunneling microscopy and tip-enhanced Raman spectroscopy.	Sulfhydryl Compounds	75-80	TOR signaling pathway regulator	Homo sapiens	164-167
29203246-5	2018	This paper provides evidences that binding to integrin ligands initiate changes in free thiol pattern on cell surface and that thiol-disulfide exchange mediated by PDI leads to activation of integrin subunit alpha11.	Sulfhydryl Compounds	88-93	prolyl 4-hydroxylase subunit beta	Homo sapiens	164-167
29203246-5	2018	This paper provides evidences that binding to integrin ligands initiate changes in free thiol pattern on cell surface and that thiol-disulfide exchange mediated by PDI leads to activation of integrin subunit alpha11.	Sulfhydryl Compounds	88-93	integrin subunit alpha 11	Homo sapiens	191-215
29203246-5	2018	This paper provides evidences that binding to integrin ligands initiate changes in free thiol pattern on cell surface and that thiol-disulfide exchange mediated by PDI leads to activation of integrin subunit alpha11.	Sulfhydryl Compounds	127-132	prolyl 4-hydroxylase subunit beta	Homo sapiens	164-167
29311554-6	2018	However, loss in covalent-bound LC3 also sensitizes the catalytic thiols of Atg3 and Atg7 to inhibitory oxidation that prevents LC3 lipidation, observed in vitro and in mouse aorta.	Sulfhydryl Compounds	66-72	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	32-35
29203246-5	2018	This paper provides evidences that binding to integrin ligands initiate changes in free thiol pattern on cell surface and that thiol-disulfide exchange mediated by PDI leads to activation of integrin subunit alpha11.	Sulfhydryl Compounds	127-132	integrin subunit alpha 11	Homo sapiens	191-215
28763763-6	2018	The long-chain aliphatic thiols act as spacers between CDA and AuNP.	Sulfhydryl Compounds	25-31	cytidine deaminase	Homo sapiens	55-58
29311554-6	2018	However, loss in covalent-bound LC3 also sensitizes the catalytic thiols of Atg3 and Atg7 to inhibitory oxidation that prevents LC3 lipidation, observed in vitro and in mouse aorta.	Sulfhydryl Compounds	66-72	autophagy related 3	Mus musculus	76-80
29154837-2	2018	Nrf2 activators often exhibit cytotoxicity due to nonspecific electrophilic reactions with thiol groups.	Sulfhydryl Compounds	91-96	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
28763763-7	2018	Interestingly, the fluorescence of CDA is observed to be enhanced successively as the chain lengths of aliphatic thiols are increased.	Sulfhydryl Compounds	113-119	cytidine deaminase	Homo sapiens	35-38
29298981-7	2018	Thus, regulation of PRIN2 is the thiol-mediated mechanism required for full PEP activity, with PRIN2 monomerization via reduction by TRXs providing a mechanistic link between photosynthetic electron transport and activation of photosynthetic gene expression.	Sulfhydryl Compounds	33-38	Serine/Threonine-kinase	Arabidopsis thaliana	20-25
29298981-7	2018	Thus, regulation of PRIN2 is the thiol-mediated mechanism required for full PEP activity, with PRIN2 monomerization via reduction by TRXs providing a mechanistic link between photosynthetic electron transport and activation of photosynthetic gene expression.	Sulfhydryl Compounds	33-38	RNA-binding KH domain-containing protein	Arabidopsis thaliana	76-79
28398822-2	2018	The peroxidase peroxiredoxin 1 (PRDX1) regulates signal transduction through changes in thiol oxidation of its cysteines.	Sulfhydryl Compounds	88-93	peroxiredoxin 1	Homo sapiens	15-30
28398822-2	2018	The peroxidase peroxiredoxin 1 (PRDX1) regulates signal transduction through changes in thiol oxidation of its cysteines.	Sulfhydryl Compounds	88-93	peroxiredoxin 1	Homo sapiens	32-37
29746182-3	2018	During active autophagy, LC3 is transferred from the catalytic thiol of ATG7 to the active site thiol of ATG3, where it is conjugated to phosphatidylethanolamine.	Sulfhydryl Compounds	63-68	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	25-28
29873527-0	2018	Magnetic Fe3O4@MCM-41 core-shell nanoparticles functionalized with thiol silane for efficient l-asparaginase immobilization.	Sulfhydryl Compounds	67-72	asparaginase and isoaspartyl peptidase 1	Homo sapiens	94-108
29873527-6	2018	l-ASNase was covalently immobilized onto the thiol-functionalized Fe3O4@MCM-41 magnetic nanoparticles.	Sulfhydryl Compounds	45-50	asparaginase and isoaspartyl peptidase 1	Homo sapiens	0-8
29873527-12	2018	Thereby, the results confirmed that thiol-functionalized Fe3O4@MCM-41 magnetic nanoparticles had high efficiency for l-ASNase immobilization and improved stability of L-ASNase.	Sulfhydryl Compounds	36-41	asparaginase and isoaspartyl peptidase 1	Homo sapiens	117-125
29873527-12	2018	Thereby, the results confirmed that thiol-functionalized Fe3O4@MCM-41 magnetic nanoparticles had high efficiency for l-ASNase immobilization and improved stability of L-ASNase.	Sulfhydryl Compounds	36-41	asparaginase and isoaspartyl peptidase 1	Homo sapiens	167-175
29746182-3	2018	During active autophagy, LC3 is transferred from the catalytic thiol of ATG7 to the active site thiol of ATG3, where it is conjugated to phosphatidylethanolamine.	Sulfhydryl Compounds	63-68	autophagy related 7	Mus musculus	72-76
29746182-3	2018	During active autophagy, LC3 is transferred from the catalytic thiol of ATG7 to the active site thiol of ATG3, where it is conjugated to phosphatidylethanolamine.	Sulfhydryl Compounds	96-101	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	25-28
29746182-3	2018	During active autophagy, LC3 is transferred from the catalytic thiol of ATG7 to the active site thiol of ATG3, where it is conjugated to phosphatidylethanolamine.	Sulfhydryl Compounds	96-101	autophagy related 3	Mus musculus	105-109
29746182-4	2018	In our recent study, we show LC3 is bound to the catalytic thiols of inactive ATG3 and ATG7 through a stable thioester, which becomes transient upon autophagy stimulation.	Sulfhydryl Compounds	59-65	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	29-32
29746182-4	2018	In our recent study, we show LC3 is bound to the catalytic thiols of inactive ATG3 and ATG7 through a stable thioester, which becomes transient upon autophagy stimulation.	Sulfhydryl Compounds	59-65	autophagy related 3	Mus musculus	78-82
29746182-4	2018	In our recent study, we show LC3 is bound to the catalytic thiols of inactive ATG3 and ATG7 through a stable thioester, which becomes transient upon autophagy stimulation.	Sulfhydryl Compounds	59-65	autophagy related 7	Mus musculus	87-91
29146186-5	2018	TMalpha and TM"s D123, but not D1, promoted the thrombin-dependent degradation of all-thiol (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), an effect mimicked by TM"s D2, though to a lesser extent.	Sulfhydryl Compounds	86-91	coagulation factor II	Mus musculus	48-56
29146186-5	2018	TMalpha and TM"s D123, but not D1, promoted the thrombin-dependent degradation of all-thiol (at-HMGB1) and disulfide HMGB1 (ds-HMGB1), an effect mimicked by TM"s D2, though to a lesser extent.	Sulfhydryl Compounds	86-91	high mobility group box 1	Mus musculus	96-101
29746182-5	2018	Transient interaction with LC3 exposes the catalytic thiols on ATG3 and ATG7, which under pro-oxidizing conditions undergo inhibitory oxidation.	Sulfhydryl Compounds	53-59	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	27-30
29746182-5	2018	Transient interaction with LC3 exposes the catalytic thiols on ATG3 and ATG7, which under pro-oxidizing conditions undergo inhibitory oxidation.	Sulfhydryl Compounds	53-59	autophagy related 3	Mus musculus	63-67
29746182-5	2018	Transient interaction with LC3 exposes the catalytic thiols on ATG3 and ATG7, which under pro-oxidizing conditions undergo inhibitory oxidation.	Sulfhydryl Compounds	53-59	autophagy related 7	Mus musculus	72-76
29260407-0	2018	Does thiol-disulphide balance show oxidative stress in different MEFV mutations?	Sulfhydryl Compounds	5-10	MEFV innate immuity regulator, pyrin	Homo sapiens	65-69
29145138-6	2018	IPOH [500 muM] caused a decrease in the thiol-state balance (e.g. after 2 h, GSH:GSSG was reduced by 37% compared to the untreated 16HBE14o-cells).	Sulfhydryl Compounds	40-45	latexin	Homo sapiens	10-13
31355358-5	2018	TXNIP binds to and inhibits the anti-oxidant and thiol reducing capacity of thioredoxins and causes cellular oxidative stress, inflammation and premature cell death.	Sulfhydryl Compounds	49-54	thioredoxin interacting protein	Homo sapiens	0-5
29952411-8	2018	Alteration in nitrotyrosine concentrations correlated with testosterone, DHEAS, androstenediones, FAI, and LH, while changes in thiol groups cor-related with DHEAS.	Sulfhydryl Compounds	128-133	sulfotransferase family 2A member 1	Homo sapiens	158-163
30062411-3	2018	S-glutathionylation, the adduction of glutathione to cysteine residues in Rac1, is a redox-dependent thiol modification and is generally associated with oxidative/nitrosative stress, representing a novel mechanism of GTPase regulation.	Sulfhydryl Compounds	101-106	Rac family small GTPase 1	Homo sapiens	74-78
31106306-5	2018	TXNIP"s actions involve binding to and inhibition of anti-oxidant and thiol-reducing capacities of thioredoxins (Trx) causing cellular oxidative stress and apoptosis.	Sulfhydryl Compounds	70-75	thioredoxin interacting protein	Homo sapiens	0-5
28640934-4	2018	UGT activity using UDP-glucose as donor was then determined using 11 synthetic acceptors bearing hydroxyl, amino and thiol groups that had been shown to undergo conjugation in plant extracts.	Sulfhydryl Compounds	117-122	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-3
29669353-15	2018	The effects of cinobufagin on cell proliferation, apoptosis, ROS generation and DeltaPsim loss were dramatically reversed when the cells were pretreated with the thiol-antioxidants NAC or GSH.	Sulfhydryl Compounds	162-167	X-linked Kx blood group	Homo sapiens	181-184
29600453-1	2018	S-nitrosylation (or S-nitrosation, SNO) is an oxidative posttranslational modification to the thiol group of a cysteine amino acid residue.	Sulfhydryl Compounds	94-99	strawberry notch homolog 1	Homo sapiens	35-38
29129062-5	2017	For a standard pilsner beer with 35 international bitter units with typical concentrations of thiols and hop bitter acids, thiols were found to react with ca.	Sulfhydryl Compounds	123-129	HOP homeobox	Homo sapiens	105-108
28764013-4	2017	Using the proposed SIL-SPE-LC-DPIS/DNLS-MS methods, 76 thiol and 25 aldehyde candidates were found in beer.	Sulfhydryl Compounds	55-60	STIL centriolar assembly protein	Homo sapiens	19-22
28764013-5	2017	Furthermore, we established SIL-SPE-LC-MRM-MS methods for the relative quantitation of thiols and aldehydes in different beer samples.	Sulfhydryl Compounds	87-93	STIL centriolar assembly protein	Homo sapiens	28-31
29172459-7	2017	NMR structural analysis and molecular docking studies suggest that a single Fe2+ ion is chelated by thiol side chains from Cys15 and Cys17 in the GCAP5 dimer, forming an [Fe(SCys)4] complex like that observed previously in two-iron superoxide reductases.	Sulfhydryl Compounds	100-105	guanylate cyclase activator 1e	Danio rerio	146-151
29214517-3	2017	One cysteine mutated calmodulin (CaM), as a model protein, was immobilized on thiol-terminated pattern surfaces.	Sulfhydryl Compounds	78-83	calmodulin 1	Homo sapiens	21-31
29214517-3	2017	One cysteine mutated calmodulin (CaM), as a model protein, was immobilized on thiol-terminated pattern surfaces.	Sulfhydryl Compounds	78-83	calmodulin 1	Homo sapiens	33-36
28939006-1	2017	We have introduced protein thiolation index (PTI), i.e. the molar ratio of the sum of all low molecular mass thiols bound to plasma proteins to protein free cysteinyl residues, as a sensitive biomarker of oxidative stress.	Sulfhydryl Compounds	109-115	serpin family B member 6	Homo sapiens	45-48
28916472-6	2017	After GD10.6, the EMB maintains the amino acid intake flux, resulting in a significant depletion of most thiols in the amniotic fluid and the yolk sac fluid.	Sulfhydryl Compounds	105-111	embigin	Rattus norvegicus	18-21
28935607-11	2017	The mixed disulfide and the C150-C154 disulfide bond protect GAPDH from irreversible oxidation and can be reduced in the excess of thiols.	Sulfhydryl Compounds	131-137	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	61-66
31457357-14	2017	Again, in organic solvents, thiol or amine-induced quenched fluorescence is selectively recovered by Pb(II) ion without any alteration of excitation and emission maxima.	Sulfhydryl Compounds	28-33	submaxillary gland androgen regulated protein 3B	Homo sapiens	101-107
28776438-2	2017	We now characterized the interaction of thiol-containing compounds with CN1 cysteine residue at position 102, which is important for CN1 activity.	Sulfhydryl Compounds	40-45	carnosine dipeptidase 1	Homo sapiens	72-75
28776438-2	2017	We now characterized the interaction of thiol-containing compounds with CN1 cysteine residue at position 102, which is important for CN1 activity.	Sulfhydryl Compounds	40-45	carnosine dipeptidase 1	Homo sapiens	133-136
28945705-2	2017	We developed thiol(SH)-linked alkylation for the metabolic sequencing of RNA (SLAM seq), an orthogonal-chemistry-based RNA sequencing technology that detects 4-thiouridine (s4U) incorporation in RNA species at single-nucleotide resolution.	Sulfhydryl Compounds	13-18	signaling lymphocytic activation molecule family member 1	Mus musculus	78-82
28939765-1	2017	Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds.	Sulfhydryl Compounds	63-68	thioredoxin	Homo sapiens	15-19
28943453-2	2017	Here we attempted to reveal how titin isoform composition and oxidative insults (i.e. sulfhydryl (SH)-group oxidation or carbonylation) influence Fpassive of left ventricular (LV) cardiomyocytes during rat heart development.	Sulfhydryl Compounds	86-96	titin	Rattus norvegicus	32-37
28513872-4	2017	Here, we found that NPM regulated the expression of peroxiredoxin 6 (PRDX6), a member of thiol-specific antioxidant protein family, consequently affected the level and distribution of ROS.	Sulfhydryl Compounds	89-94	nucleophosmin 1	Homo sapiens	20-23
28513872-4	2017	Here, we found that NPM regulated the expression of peroxiredoxin 6 (PRDX6), a member of thiol-specific antioxidant protein family, consequently affected the level and distribution of ROS.	Sulfhydryl Compounds	89-94	peroxiredoxin 6	Homo sapiens	52-67
28513872-4	2017	Here, we found that NPM regulated the expression of peroxiredoxin 6 (PRDX6), a member of thiol-specific antioxidant protein family, consequently affected the level and distribution of ROS.	Sulfhydryl Compounds	89-94	peroxiredoxin 6	Homo sapiens	69-74
29095609-7	2017	In good agreement, both techniques suggest the binding affinity of the mono(NHC) Au(I) complexes toward selenols and thiols.	Sulfhydryl Compounds	117-123	high mobility group nucleosomal binding domain 4	Homo sapiens	76-79
28622643-2	2017	In the presence of targets, the thiol-modified hairpin capture probes (HCP1 and HCP2) specifically hybridize with miR-141 and miR-21 on a gold electrode, leading to the conformation change of HCP1 and HCP2, respectively.	Sulfhydryl Compounds	32-37	CYCS pseudogene 51	Homo sapiens	71-75
31457357-16	2017	The fluorescence recovery by Pb(II) and unaltered emission peak only in nonaqueous solvent unequivocally prove the engagement of Pb(II) with thiols or amines, which in turn revert the original solvent-supported stabilization of the assembly.	Sulfhydryl Compounds	141-147	submaxillary gland androgen regulated protein 3B	Homo sapiens	129-135
28622643-2	2017	In the presence of targets, the thiol-modified hairpin capture probes (HCP1 and HCP2) specifically hybridize with miR-141 and miR-21 on a gold electrode, leading to the conformation change of HCP1 and HCP2, respectively.	Sulfhydryl Compounds	32-37	CYCS pseudogene 52	Homo sapiens	80-84
28443683-5	2017	The Trx and GSH systems, which reversibly regulate thiol modifications, regulate redox signaling involved in various biological events in the CNS.	Sulfhydryl Compounds	51-56	thioredoxin	Homo sapiens	4-7
28622643-2	2017	In the presence of targets, the thiol-modified hairpin capture probes (HCP1 and HCP2) specifically hybridize with miR-141 and miR-21 on a gold electrode, leading to the conformation change of HCP1 and HCP2, respectively.	Sulfhydryl Compounds	32-37	microRNA 141	Homo sapiens	114-121
28622643-2	2017	In the presence of targets, the thiol-modified hairpin capture probes (HCP1 and HCP2) specifically hybridize with miR-141 and miR-21 on a gold electrode, leading to the conformation change of HCP1 and HCP2, respectively.	Sulfhydryl Compounds	32-37	microRNA 21	Homo sapiens	126-132
28622643-2	2017	In the presence of targets, the thiol-modified hairpin capture probes (HCP1 and HCP2) specifically hybridize with miR-141 and miR-21 on a gold electrode, leading to the conformation change of HCP1 and HCP2, respectively.	Sulfhydryl Compounds	32-37	CYCS pseudogene 51	Homo sapiens	192-196
28622643-2	2017	In the presence of targets, the thiol-modified hairpin capture probes (HCP1 and HCP2) specifically hybridize with miR-141 and miR-21 on a gold electrode, leading to the conformation change of HCP1 and HCP2, respectively.	Sulfhydryl Compounds	32-37	CYCS pseudogene 52	Homo sapiens	201-205
29071315-2	2017	In the presence of BCl3 as the sole boron source, the boryl group and thiol group are added to the C-C double bonds simultaneously.	Sulfhydryl Compounds	70-75	BCL3 transcription coactivator	Homo sapiens	19-23
28443683-6	2017	CRITICAL ISSUES: In this review, we focus on the following: (i) how ROS/RNS are produced and mediate signaling in CNS; (ii) how Trx and GSH systems regulate redox signaling by catalyzing reversible thiol modifications; (iii) how dysfunction of the Trx and GSH systems causes alterations of cellular redox signaling in human neuronal diseases; and (iv) the effects of certain small molecules that target thiol-based signaling pathways in the CNS.	Sulfhydryl Compounds	198-203	thioredoxin	Homo sapiens	128-131
28443683-6	2017	CRITICAL ISSUES: In this review, we focus on the following: (i) how ROS/RNS are produced and mediate signaling in CNS; (ii) how Trx and GSH systems regulate redox signaling by catalyzing reversible thiol modifications; (iii) how dysfunction of the Trx and GSH systems causes alterations of cellular redox signaling in human neuronal diseases; and (iv) the effects of certain small molecules that target thiol-based signaling pathways in the CNS.	Sulfhydryl Compounds	198-203	thioredoxin	Homo sapiens	248-251
28443683-6	2017	CRITICAL ISSUES: In this review, we focus on the following: (i) how ROS/RNS are produced and mediate signaling in CNS; (ii) how Trx and GSH systems regulate redox signaling by catalyzing reversible thiol modifications; (iii) how dysfunction of the Trx and GSH systems causes alterations of cellular redox signaling in human neuronal diseases; and (iv) the effects of certain small molecules that target thiol-based signaling pathways in the CNS.	Sulfhydryl Compounds	403-408	thioredoxin	Homo sapiens	128-131
28672263-7	2017	The SPI nanoaggregates were used to prepare oil-in-water nanoemulsions with canola oil, which exhibited good stability over 21days at 4 C. In addition, the pH 12-MTS samples had resulted in the highest protein solubility, lowest turbidity, free sulfhydryl and disulfide bonds, surface hydrophobicity, antioxidant activity, and rheological and emulsifying properties than the other samples.	Sulfhydryl Compounds	245-255	chromogranin A	Homo sapiens	4-7
29016988-1	2017	Once the ferredoxin/thioredoxin system was established as a mechanism linking light to the post-translational regulation of chloroplast enzymes, I considered that plants might harbor a light-independent mechanism utilizing this same enzyme chemistry based on thiol-disulfide redox transitions.	Sulfhydryl Compounds	259-264	thioredoxin	Homo sapiens	20-31
28830914-11	2017	The thiol-containing molecules l-cysteine and d-cysteine both mimicked the protective effects of NAC, whereas the thiol-lacking molecule N-acetyl-S-methyl-l-cysteine failed to exert protection or blunt the rise in ubiquitinated proteins.	Sulfhydryl Compounds	4-9	X-linked Kx blood group	Homo sapiens	97-100
28830914-12	2017	Collectively, these findings suggest that the thiol group in NAC is required for its effects on glial viability and protein quality control.	Sulfhydryl Compounds	46-51	X-linked Kx blood group	Homo sapiens	61-64
29084526-7	2017	AtFC1 overexpression (35S::FC1) lines accumulated more Cd and non-protein thiol compounds than wild-type, and conferred plant tolerance to Cd stress, with improved primary root elongation, biomass and chlorophyll (Chl) content, and low degree of oxidation associated with reduced H2O2, O 2- and peroxides.	Sulfhydryl Compounds	74-79	serine/threonine-protein kinase AFC1	Arabidopsis thaliana	0-5
30023543-3	2017	Other thiol-reactive electrophiles have also been shown to induce the heat shock response as well as to covalently adduct members of the heat shock protein family, such as heat shock protein 72 (Hsp72).	Sulfhydryl Compounds	6-11	heat shock protein family A (Hsp70) member 1A	Homo sapiens	172-193
30023543-3	2017	Other thiol-reactive electrophiles have also been shown to induce the heat shock response as well as to covalently adduct members of the heat shock protein family, such as heat shock protein 72 (Hsp72).	Sulfhydryl Compounds	6-11	heat shock protein family A (Hsp70) member 1A	Homo sapiens	195-200
30023522-2	2017	Thiols or thiolates would be likely biological targets for an electrophile, such as CS2, and in this context, the present study examines the dynamics of CS2 reactions with various thiols (RSH) in physiologically relevant near-neutral aqueous media to form the respective trithiocarbonate anions (TTC-, also known as "thioxanthate anions").	Sulfhydryl Compounds	0-6	chorionic somatomammotropin hormone 2	Homo sapiens	84-87
30023522-2	2017	Thiols or thiolates would be likely biological targets for an electrophile, such as CS2, and in this context, the present study examines the dynamics of CS2 reactions with various thiols (RSH) in physiologically relevant near-neutral aqueous media to form the respective trithiocarbonate anions (TTC-, also known as "thioxanthate anions").	Sulfhydryl Compounds	180-186	chorionic somatomammotropin hormone 2	Homo sapiens	153-156
29084526-7	2017	AtFC1 overexpression (35S::FC1) lines accumulated more Cd and non-protein thiol compounds than wild-type, and conferred plant tolerance to Cd stress, with improved primary root elongation, biomass and chlorophyll (Chl) content, and low degree of oxidation associated with reduced H2O2, O 2- and peroxides.	Sulfhydryl Compounds	74-79	ferrochelatase 1	Arabidopsis thaliana	2-5
28560860-5	2017	The change in apparent redness is mainly caused by redox reaction of the nitroso hemochromogen (NH) (eigenvectors of a*, C and NH in PC1 were all the maximum value of 0.28); a* was correlated with NH (0.96), free sulfhydryls (0.98), carbonyl derivatives (-0.95) formed during protein oxidation, and malondialdehyde (-0.98) and dienes (-0.92) formed by lipid oxidation.	Sulfhydryl Compounds	213-224	polycystin 1, transient receptor potential channel interacting	Homo sapiens	133-136
28632338-1	2017	The relevance of the -CF2 H moiety has attracted considerable attention from organic synthetic and medicinal chemistry communities, because this group can act as a more lipophilic isostere of the carbinol, thiol, hydroxamic acid, or amide groups.	Sulfhydryl Compounds	206-211	ATPase H+ transporting accessory protein 1	Homo sapiens	22-25
29049363-3	2017	The majority of circulating beta2GPI is biochemically reduced with two free thiols in Domain V. However, increased levels of oxidised beta2GPI are found in patients with antiphospholipid syndrome (APS).	Sulfhydryl Compounds	76-82	apolipoprotein H	Homo sapiens	28-36
29049363-10	2017	This study demonstrates that oxidised beta2GPI lacking free cysteine-thiol groups most closely associates with IgG anti-DI positivity compared to IgG anti-CL and anti-beta2GPI.	Sulfhydryl Compounds	69-74	apolipoprotein H	Homo sapiens	38-46
28823538-4	2017	Initial mechanistic insights have also been gained on the gold complex [Au(C^N^C)(GluS)] (3), and support the idea that the thioredoxin system may be a target for this family of compounds together with other relevant intracellular thiol-containing molecules.	Sulfhydryl Compounds	231-236	thioredoxin	Homo sapiens	124-135
28820574-0	2017	Thiol-Containing Metallo-beta-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem.	Sulfhydryl Compounds	0-5	hypothetical protein	Klebsiella pneumoniae	17-39
28820574-3	2017	We here examine the ability of previously reported thiol-based MBL inhibitors to synergize with meropenem and cefoperazone against a panel of Gram-negative carbapenem-resistant isolates expressing different beta-lactamases.	Sulfhydryl Compounds	51-56	hypothetical protein	Klebsiella pneumoniae	63-66
28806702-6	2017	Consequently, HMGB1 oxidation increased in the cytoplasm of kidney cells during its translocation from the nucleus to the circulation, with the degree of oxidation dependent on the severity of sepsis, as measured in in vivo mouse samples using a thiol assay and mass spectrometry (LC-MS/MS).	Sulfhydryl Compounds	246-251	high mobility group box 1	Mus musculus	14-19
28827476-8	2017	Immunoblotting of cortical homogenate cross-linked with zero-length oxidative (sulfhydryl groups) cross-linker cupric-phenanthroline revealed a shift of AT2R and MasR bands upward with overlapping migration for their complexes which were sensitive to the reducing beta-mercaptoethanol, suggesting involvement of -SH groups in cross-linking.	Sulfhydryl Compounds	79-89	angiotensin II receptor, type 2	Rattus norvegicus	153-157
28827476-8	2017	Immunoblotting of cortical homogenate cross-linked with zero-length oxidative (sulfhydryl groups) cross-linker cupric-phenanthroline revealed a shift of AT2R and MasR bands upward with overlapping migration for their complexes which were sensitive to the reducing beta-mercaptoethanol, suggesting involvement of -SH groups in cross-linking.	Sulfhydryl Compounds	79-89	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	162-166
28875601-5	2017	A newly developed spectrophotometric method was used to measure native thiol (NT) and disulfide (DS) levels in FMF patients and an age-sex matched group of healthy controls.	Sulfhydryl Compounds	71-76	MEFV innate immuity regulator, pyrin	Homo sapiens	111-114
28875601-8	2017	NT (P &lt; 0.001) and total thiol (TT) (P &lt; 0.001) levels in FMF patients were significantly lower compared to healthy controls.	Sulfhydryl Compounds	28-33	MEFV innate immuity regulator, pyrin	Homo sapiens	64-67
28578274-2	2017	Using purified xanthine oxidoreductase (XOR), chemiluminescence and electron paramagnetic resonance (EPR) spectroscopy, we found that XOR catalyzes nitric oxide (NO) generation from NDHP under anaerobic conditions, and that thiols are not involved or required in this process.	Sulfhydryl Compounds	224-230	xanthine dehydrogenase	Rattus norvegicus	134-137
28826737-5	2017	This aromatic thiol closely approximates the catecholic substrate of homoprotocatechuate of 2, 3-HPCD while maintaining the 2-carbon thiol-amine separation preferred by Mm CDO.	Sulfhydryl Compounds	14-19	cysteine dioxygenase 1, cytosolic	Mus musculus	172-175
28836015-7	2017	All Grx3 derivatives were reconstituted by standard chemical reconstitution protocols and found to transfer cluster to apo ferredoxin 1 (Fdx1) at rates comparable to native protein, even when using DTT, BME or free L-cysteine as a thiol source in place of GSH during reconstitution.	Sulfhydryl Compounds	231-236	glutaredoxin 3	Homo sapiens	4-8
28875601-0	2017	Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?	Sulfhydryl Compounds	8-13	MEFV innate immuity regulator, pyrin	Homo sapiens	77-105
28875601-4	2017	The aim of this study was to investigate the relationship between thiol-disulfide balance and colchicine resistance in FMF patients during an attack or attack-free period.	Sulfhydryl Compounds	66-71	MEFV innate immuity regulator, pyrin	Homo sapiens	119-122
28808108-6	2017	In this paper we focus on the recent reports on specificity and networking of chloroplast thioredoxin systems and evaluate the prospect of improving photosynthetic performance by modifying the activity of thiol regulators in plants.This article is part of the themed issue "Enhancing photosynthesis in crop plants: targets for improvement".	Sulfhydryl Compounds	205-210	thioredoxin	Homo sapiens	90-101
31457864-1	2017	We have combined results from several spectroscopic techniques to investigate the aerobic reactions of Rh2(AcO)4 (AcO- = CH3COO-) with l-cysteine (H2Cys) and its derivatives d-penicillamine (3,3"-dimethylcysteine, H2Pen), with steric hindrance at the thiol group, and N-acetyl-l-cysteine (H2NAC), with its amino group blocked.	Sulfhydryl Compounds	251-256	Rh associated glycoprotein	Homo sapiens	103-112
28903783-13	2017	beta2GPI was then reduced by TRX-1/DTT in vitro; the free thiols were detected on Cys288 and Cys326 in domain V of beta2GPI.	Sulfhydryl Compounds	58-64	apolipoprotein H	Homo sapiens	115-123
28903783-6	2017	Glutathione (GSH) was selected to block the free thiols in reduced beta2GPI.	Sulfhydryl Compounds	49-55	apolipoprotein H	Homo sapiens	67-75
28903783-16	2017	CONCLUSION: Stable reduced beta2GPI can be obtained in vitro by TRX-1 deoxidation followed by the blockage of thiols with GSH.	Sulfhydryl Compounds	110-116	apolipoprotein H	Homo sapiens	27-35
28825482-2	2017	The interface platform is created using a maleimide-functionalized parylene coating (maleimide-PPX) that provides two routes for controlled conjugation accessibility, including the maleimide-thiol coupling reaction and the thiol-ene click reaction, with a high reaction specificity under mild conditions.	Sulfhydryl Compounds	191-196	protein phosphatase 4, catalytic subunit	Mus musculus	95-98
28887543-3	2017	Here, we report that a cysteine thiol redox sensor contributes to the role of SIRT6 in controlling glucose homeostasis.	Sulfhydryl Compounds	32-37	sirtuin 6	Homo sapiens	78-83
28894122-5	2017	They can recruit/release monomeric RRM2 through thiol-disulfide exchange reactions.	Sulfhydryl Compounds	48-53	ribonucleotide reductase regulatory subunit M2	Homo sapiens	35-39
28533090-4	2017	This technique avoids many of the problems associate with the previously reported method of using a thiol-reactive fluorescence probes to measure AHCY activity.	Sulfhydryl Compounds	100-105	adenosylhomocysteinase	Homo sapiens	146-150
28887543-8	2017	These results suggest that direct and reversible cysteine thiol 144 may play a functional role in SIRT6-dependent control over monocyte glycolysis, an important determinant of effector innate immune responses.	Sulfhydryl Compounds	58-63	sirtuin 6	Homo sapiens	98-103
28668728-5	2017	IRC7 gene, previously described in S. cerevisiae, has been identified in T. delbrueckii, establishing the genetics basis of its thiol-releasing capability.	Sulfhydryl Compounds	128-133	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	0-4
28576878-12	2017	ERp72 bound poorly to beta3-null mouse platelets, and the addition of ERp72(oo-ss-ss) to human platelets generated thiols in alphaIIbbeta3, suggesting a direct interaction of ERp72 with alphaIIbbeta3.	Sulfhydryl Compounds	115-121	protein disulfide isomerase associated 4	Mus musculus	70-75
28746987-3	2017	The major thiol-reducing pathways engage the thioredoxin and the glutaredoxin systems which are involved in removal of oxidants, protein proofreading and folding.	Sulfhydryl Compounds	10-15	thioredoxin	Homo sapiens	45-56
28746987-3	2017	The major thiol-reducing pathways engage the thioredoxin and the glutaredoxin systems which are involved in removal of oxidants, protein proofreading and folding.	Sulfhydryl Compounds	10-15	glutaredoxin	Homo sapiens	65-77
28659344-0	2017	Guanylyl cyclase sensitivity to nitric oxide is protected by a thiol oxidation-driven interaction with thioredoxin-1.	Sulfhydryl Compounds	63-68	thioredoxin	Homo sapiens	103-116
28659344-4	2017	In animal models of nitrate tolerance and angiotensin II-induced hypertension, decreased vasodilation in response to NO correlates with GC1 thiol oxidation, but the physiological mechanism that resensitizes GC1 to NO and restores basal activity is unknown.	Sulfhydryl Compounds	140-145	solute carrier family 25 member 22	Homo sapiens	136-139
28659344-5	2017	Because GC1 interacts with the oxidoreductase protein-disulfide isomerase, we hypothesized that thioredoxin-1 (Trx1), a cytosolic oxidoreductase, could be involved in restoring GC1 basal activity and NO sensitivity because the Trx/thioredoxin reductase (TrxR) system maintains thiol redox homeostasis.	Sulfhydryl Compounds	277-282	solute carrier family 25 member 22	Homo sapiens	8-11
28659344-5	2017	Because GC1 interacts with the oxidoreductase protein-disulfide isomerase, we hypothesized that thioredoxin-1 (Trx1), a cytosolic oxidoreductase, could be involved in restoring GC1 basal activity and NO sensitivity because the Trx/thioredoxin reductase (TrxR) system maintains thiol redox homeostasis.	Sulfhydryl Compounds	277-282	thioredoxin	Homo sapiens	96-109
28659344-5	2017	Because GC1 interacts with the oxidoreductase protein-disulfide isomerase, we hypothesized that thioredoxin-1 (Trx1), a cytosolic oxidoreductase, could be involved in restoring GC1 basal activity and NO sensitivity because the Trx/thioredoxin reductase (TrxR) system maintains thiol redox homeostasis.	Sulfhydryl Compounds	277-282	thioredoxin	Homo sapiens	111-115
28659344-5	2017	Because GC1 interacts with the oxidoreductase protein-disulfide isomerase, we hypothesized that thioredoxin-1 (Trx1), a cytosolic oxidoreductase, could be involved in restoring GC1 basal activity and NO sensitivity because the Trx/thioredoxin reductase (TrxR) system maintains thiol redox homeostasis.	Sulfhydryl Compounds	277-282	thioredoxin	Homo sapiens	111-114
28671680-1	2017	Thioredoxin (Trx) is one of the two major thiol antioxidants, playing essential roles in redox homeostasis and signaling.	Sulfhydryl Compounds	42-47	thioredoxin	Homo sapiens	0-11
28671680-1	2017	Thioredoxin (Trx) is one of the two major thiol antioxidants, playing essential roles in redox homeostasis and signaling.	Sulfhydryl Compounds	42-47	thioredoxin	Homo sapiens	13-16
28810662-5	2017	While endogenous galectin-9 is not required for basal cell surface PDI expression, exogenous galectin-9 mediated retention of cell surface PDI shifted the disulfide/thiol equilibrium on the T cell surface.	Sulfhydryl Compounds	165-170	galectin 9	Homo sapiens	93-103
28653773-4	2017	Thiol-functionalized transferrin (Tf-SH) is anchored onto the surface of MoS2 nanosheets by the formation of disulfide bonds, which could further enhance the cellular uptake of DOX and MoS2 to HepG2 cells for high-efficiency synergetic therapy.	Sulfhydryl Compounds	0-5	transferrin	Homo sapiens	21-32
28576878-12	2017	ERp72 bound poorly to beta3-null mouse platelets, and the addition of ERp72(oo-ss-ss) to human platelets generated thiols in alphaIIbbeta3, suggesting a direct interaction of ERp72 with alphaIIbbeta3.	Sulfhydryl Compounds	115-121	protein disulfide isomerase family A member 4	Homo sapiens	70-75
27509825-0	2017	The matricellular ligand Cyr61 contributes to the metastatic spread of tumors by activating integrin VLA-4, independently of thiol redox modulation : .	Sulfhydryl Compounds	125-130	cellular communication network factor 1	Homo sapiens	25-30
28342314-2	2017	The thiol terminated capture probe 1 (SH-P1) was immobilized on the electrode through AuS interaction.	Sulfhydryl Compounds	4-9	nuclear receptor subfamily 0 group B member 2	Homo sapiens	38-43
28528273-0	2017	Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C.	Sulfhydryl Compounds	12-18	cathepsin C	Homo sapiens	110-121
28528273-1	2017	Addition of thiols to double bond of glycyl-dehydroalanine and phenyl-dehydroalanine esters provided micromolar inhibitors of cathepsin C.	Sulfhydryl Compounds	12-18	cathepsin C	Homo sapiens	126-137
28596054-3	2017	A linear NPR3-selective peptide, [Cha8]-ANP(7-16)-NH2 (1), showed potent binding affinity for NPR3 but poor predicted chemical stability due to its free thiol group.	Sulfhydryl Compounds	153-158	natriuretic peptide receptor 3	Mus musculus	9-13
28501159-5	2017	Due to the synergic effect between the reagents DTT and ACN, DTT/ACN-based depletion offers good performance in the depletion of thiol-rich proteins, such as albumin and transferrin (DTT action), as well as of high molecular weight proteins (ACN action).	Sulfhydryl Compounds	129-134	transferrin	Homo sapiens	170-181
28391181-1	2017	Ohr and OsmC proteins comprise two subfamilies within a large group of proteins that display Cys-based, thiol dependent peroxidase activity.	Sulfhydryl Compounds	104-109	peroxidase 24	Musa acuminata	120-130
28461233-1	2017	Thiol homeostasis has a critical role in the maintenance of proper cellular functions and survival, being coordinated by the action of several reductive enzymes, including glutathione (GSH)/glutathione reductase (GR) and thioredoxin (Trx)/thioredoxin reductase (TrxR) systems.	Sulfhydryl Compounds	0-5	glutathione-disulfide reductase	Homo sapiens	190-211
28461233-1	2017	Thiol homeostasis has a critical role in the maintenance of proper cellular functions and survival, being coordinated by the action of several reductive enzymes, including glutathione (GSH)/glutathione reductase (GR) and thioredoxin (Trx)/thioredoxin reductase (TrxR) systems.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	221-232
28461233-1	2017	Thiol homeostasis has a critical role in the maintenance of proper cellular functions and survival, being coordinated by the action of several reductive enzymes, including glutathione (GSH)/glutathione reductase (GR) and thioredoxin (Trx)/thioredoxin reductase (TrxR) systems.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	234-237
28700690-4	2017	Human DGAT2 activity was considerably inhibited not only by thiol-modifying reagents (NEM and IA) but also by ROS-related chemicals (H2O2 and beta-lapachone), while human DGAT1 and GPAT1 were little affected.	Sulfhydryl Compounds	60-65	diacylglycerol O-acyltransferase 2	Homo sapiens	6-11
28461233-1	2017	Thiol homeostasis has a critical role in the maintenance of proper cellular functions and survival, being coordinated by the action of several reductive enzymes, including glutathione (GSH)/glutathione reductase (GR) and thioredoxin (Trx)/thioredoxin reductase (TrxR) systems.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	239-250
28650005-3	2017	Thrombin detection was achieved through the charge modulation of the electrical double layer due to the specific and dose dependent binding of thrombin to the surface of thiol terminated ssDNA aptamer functionalized MoS2 nanosheets.	Sulfhydryl Compounds	170-175	coagulation factor II, thrombin	Homo sapiens	0-8
28650005-3	2017	Thrombin detection was achieved through the charge modulation of the electrical double layer due to the specific and dose dependent binding of thrombin to the surface of thiol terminated ssDNA aptamer functionalized MoS2 nanosheets.	Sulfhydryl Compounds	170-175	coagulation factor II, thrombin	Homo sapiens	143-151
28700690-4	2017	Human DGAT2 activity was considerably inhibited not only by thiol-modifying reagents (NEM and IA) but also by ROS-related chemicals (H2O2 and beta-lapachone), while human DGAT1 and GPAT1 were little affected.	Sulfhydryl Compounds	60-65	diacylglycerol O-acyltransferase 1	Homo sapiens	171-176
28533092-0	2017	Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles.	Sulfhydryl Compounds	0-5	ATP binding cassette subfamily B member 1	Homo sapiens	40-54
28744126-5	2017	Tail vein injection of miR155-AuNP, in which thiol-modified antago-miR155 was covalently conjugated with gold nanoparticle (AuNP), preferentially delivered the nucleic acids into the macrophages via phagocytosis.	Sulfhydryl Compounds	45-50	microRNA 155	Mus musculus	23-29
28744126-5	2017	Tail vein injection of miR155-AuNP, in which thiol-modified antago-miR155 was covalently conjugated with gold nanoparticle (AuNP), preferentially delivered the nucleic acids into the macrophages via phagocytosis.	Sulfhydryl Compounds	45-50	microRNA 155	Mus musculus	67-73
28438657-0	2017	The thiol of human serum albumin: Acidity, microenvironment and mechanistic insights on its oxidation to sulfenic acid.	Sulfhydryl Compounds	4-9	albumin	Homo sapiens	19-32
28323130-3	2017	One group of thiol containing proteins, peroxiredoxins, in particular, have been associated with inflammation.	Sulfhydryl Compounds	13-18	peroxiredoxin 1	Homo sapiens	40-54
28323130-4	2017	In this study, we assessed surface thiols of the U937 and Thp1 monocyte cell lines and primary monocytes in vitro upon inflammatory stimulation by irreversibly labelling the cells with a fluorescent derivative of maleimide.	Sulfhydryl Compounds	35-41	GLI family zinc finger 2	Homo sapiens	58-62
28323130-8	2017	We found an increase in exofacial thiols on monocytes upon in vitro stimulation by LPS or TNF, both in primary monocytes and monocytic cell lines (p&lt;0.0005).	Sulfhydryl Compounds	34-40	tumor necrosis factor	Homo sapiens	90-93
28465261-0	2017	Challenges in the evaluation of thiol-reactive inhibitors of human protein disulfide Isomerase.	Sulfhydryl Compounds	32-37	prolyl 4-hydroxylase subunit beta	Homo sapiens	67-94
28465261-1	2017	This paper addresses how to evaluate the efficacy of the growing inventory of thiol-reactive inhibitors of mammalian protein disulfide Isomerase (PDI) enzymes under realistic concentrations of potentially competing thiol-containing peptides and proteins.	Sulfhydryl Compounds	78-83	prolyl 4-hydroxylase subunit beta	Homo sapiens	117-144
28465261-1	2017	This paper addresses how to evaluate the efficacy of the growing inventory of thiol-reactive inhibitors of mammalian protein disulfide Isomerase (PDI) enzymes under realistic concentrations of potentially competing thiol-containing peptides and proteins.	Sulfhydryl Compounds	78-83	prolyl 4-hydroxylase subunit beta	Homo sapiens	146-149
28465261-1	2017	This paper addresses how to evaluate the efficacy of the growing inventory of thiol-reactive inhibitors of mammalian protein disulfide Isomerase (PDI) enzymes under realistic concentrations of potentially competing thiol-containing peptides and proteins.	Sulfhydryl Compounds	215-220	prolyl 4-hydroxylase subunit beta	Homo sapiens	117-144
28495929-1	2017	OBJECTIVE: Coagulation initiation by tissue factor (TF) is regulated by cellular inhibitors, cell surface availability of procoagulant phosphatidylserine, and thiol-disulfide exchange.	Sulfhydryl Compounds	159-164	coagulation factor III, tissue factor	Homo sapiens	37-50
28495929-1	2017	OBJECTIVE: Coagulation initiation by tissue factor (TF) is regulated by cellular inhibitors, cell surface availability of procoagulant phosphatidylserine, and thiol-disulfide exchange.	Sulfhydryl Compounds	159-164	coagulation factor III, tissue factor	Homo sapiens	52-54
28359953-7	2017	RESULTS: CSE augmented the release of the EV subtype exosomes, which could be prevented by scavenging thiol-reactive components using NAC or GSH.	Sulfhydryl Compounds	102-107	X-linked Kx blood group	Homo sapiens	134-137
28438657-3	2017	Molecular dynamics simulations of HSA in the sub-microsecond timescale show that while sulfur exposure to solvent is limited and fluctuating in the thiol form, it increases in the thiolate, stabilized by a persistent hydrogen-bond (HB) network involving Tyr84 and bridging waters to Asp38 and Gln33 backbone.	Sulfhydryl Compounds	148-153	albumin	Homo sapiens	34-37
28438657-11	2017	These studies contribute to deepen the understanding of the reactivity of HSA-SH, the most abundant thiol in human plasma, and in a wider perspective, provide clues on the key aspects that modulate thiol reactivity against H2O2.	Sulfhydryl Compounds	100-105	albumin	Homo sapiens	74-77
28438657-11	2017	These studies contribute to deepen the understanding of the reactivity of HSA-SH, the most abundant thiol in human plasma, and in a wider perspective, provide clues on the key aspects that modulate thiol reactivity against H2O2.	Sulfhydryl Compounds	198-203	albumin	Homo sapiens	74-77
28465261-1	2017	This paper addresses how to evaluate the efficacy of the growing inventory of thiol-reactive inhibitors of mammalian protein disulfide Isomerase (PDI) enzymes under realistic concentrations of potentially competing thiol-containing peptides and proteins.	Sulfhydryl Compounds	215-220	prolyl 4-hydroxylase subunit beta	Homo sapiens	146-149
28465261-3	2017	This plate reader-compatible method detects human PDI down to 5-10nM, can utilize a range of thiol substrates (including 5microM dithiothreitol, 10microM reduced RNase thiols, and 5mM glutathione; GSH), and can operate from pH 6-9.5 in a variety of buffers.	Sulfhydryl Compounds	93-98	prolyl 4-hydroxylase subunit beta	Homo sapiens	50-53
27363428-4	2017	Thiols of flagellar proteins, such as outer dense fibre protein 1 (ODF1), are oxidised to form disulfides during epididymal transit and the spermatozoa become motile.	Sulfhydryl Compounds	0-6	outer dense fiber of sperm tails 1	Homo sapiens	67-71
28465261-3	2017	This plate reader-compatible method detects human PDI down to 5-10nM, can utilize a range of thiol substrates (including 5microM dithiothreitol, 10microM reduced RNase thiols, and 5mM glutathione; GSH), and can operate from pH 6-9.5 in a variety of buffers.	Sulfhydryl Compounds	168-174	prolyl 4-hydroxylase subunit beta	Homo sapiens	50-53
28465261-4	2017	PDI assays often employ low micromolar levels of substrates leading to ambiguities when thiol-directed inhibitors are evaluated.	Sulfhydryl Compounds	88-93	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-3
28465261-6	2017	Extracellular PDI faces a much lower concentration of potentially competing thiols; to assess reductase activity under these conditions, the pre-reduced PDI is treated with inhibitor and then fluorescence increase upon reduction of BD-SS is followed in the absence of additional competing thiols.	Sulfhydryl Compounds	76-82	prolyl 4-hydroxylase subunit beta	Homo sapiens	14-17
28465261-6	2017	Extracellular PDI faces a much lower concentration of potentially competing thiols; to assess reductase activity under these conditions, the pre-reduced PDI is treated with inhibitor and then fluorescence increase upon reduction of BD-SS is followed in the absence of additional competing thiols.	Sulfhydryl Compounds	289-295	prolyl 4-hydroxylase subunit beta	Homo sapiens	14-17
28465261-8	2017	Two reversible reagents, 3,4-methylenedioxy-beta-nitrostyrene (MNS) and the arsenical APAO, were found to be strong inhibitors of PDI in the absence of competing thiols, but were ineffective in the presence of 5mM GSH.	Sulfhydryl Compounds	162-168	prolyl 4-hydroxylase subunit beta	Homo sapiens	130-133
28394828-4	2017	Prevention of Rab7 oxidation by replacement of the redox-sensing thiols modulates its GTPase activity.	Sulfhydryl Compounds	65-71	RAB7, member RAS oncogene family	Mus musculus	14-18
28473247-7	2017	Precipitation of Keap1 was attenuated markedly by pretreatment with oxidized 5-ASA or a sulfhydryl donor.	Sulfhydryl Compounds	88-98	kelch like ECH associated protein 1	Homo sapiens	17-22
28479370-2	2017	Previous work showed that the S. cerevisiae OSI1 gene is highly induced by allicin and other thiol-reactive compounds, and in silico analysis revealed multiple Yap1p binding motifs in the OSI1 promoter sequence.	Sulfhydryl Compounds	93-98	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	160-165
27363428-11	2017	Our findings indicate that mBBr affects the thiol status of ODF1 in human spermatozoa and interferes with progressive motility.	Sulfhydryl Compounds	44-49	outer dense fiber of sperm tails 1	Homo sapiens	60-64
28548821-5	2017	Peptide probes immobilized on a sensing slide can recognize cathepsin B, and this can induce thiol-alkyne covalent coupling between the probe and cathepsin B.	Sulfhydryl Compounds	93-98	cathepsin B	Homo sapiens	60-71
28977909-0	2017	2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G2/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.	Sulfhydryl Compounds	201-206	glutathione-disulfide reductase	Homo sapiens	115-136
28977909-10	2017	Our results may introduce new target and approach for esophageal cancer therapy through generation of GR-mediated thiol oxidative stress.	Sulfhydryl Compounds	114-119	glutathione-disulfide reductase	Homo sapiens	102-104
28532685-7	2017	EPR Tempol signal decreased in the presence of PDI while remained unaffected when PDI thiols were previously blocked with NEM.	Sulfhydryl Compounds	86-92	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	82-85
28548821-5	2017	Peptide probes immobilized on a sensing slide can recognize cathepsin B, and this can induce thiol-alkyne covalent coupling between the probe and cathepsin B.	Sulfhydryl Compounds	93-98	cathepsin B	Homo sapiens	146-157
28559343-9	2017	In the intramolecular oxidation of PDI, a transition state is only observed if hydrogen bond donors are nearby the mixed disulfide intermediate, which emphasizes that the thermochemistry of thiol-disulfide exchange in PDI is influenced by the presence of hydrogen bond donors.	Sulfhydryl Compounds	190-195	prolyl 4-hydroxylase subunit beta	Homo sapiens	35-38
28441057-3	2017	Redox balance is maintained by prevention, interception, and repair, and concomitantly the regulatory potential of molecular thiol-driven master switches such as Nrf2/Keap1 or NF-kappaB/IkappaB is used for system-wide oxidative stress response.	Sulfhydryl Compounds	125-130	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
28441057-3	2017	Redox balance is maintained by prevention, interception, and repair, and concomitantly the regulatory potential of molecular thiol-driven master switches such as Nrf2/Keap1 or NF-kappaB/IkappaB is used for system-wide oxidative stress response.	Sulfhydryl Compounds	125-130	kelch like ECH associated protein 1	Homo sapiens	167-172
28441057-3	2017	Redox balance is maintained by prevention, interception, and repair, and concomitantly the regulatory potential of molecular thiol-driven master switches such as Nrf2/Keap1 or NF-kappaB/IkappaB is used for system-wide oxidative stress response.	Sulfhydryl Compounds	125-130	nuclear factor kappa B subunit 1	Homo sapiens	176-185
28559343-9	2017	In the intramolecular oxidation of PDI, a transition state is only observed if hydrogen bond donors are nearby the mixed disulfide intermediate, which emphasizes that the thermochemistry of thiol-disulfide exchange in PDI is influenced by the presence of hydrogen bond donors.	Sulfhydryl Compounds	190-195	prolyl 4-hydroxylase subunit beta	Homo sapiens	218-221
27957793-4	2017	Our analysis revealed up-regulated expression of proteins that form the antioxidant barrier of the cell in VEGF-D-treated human umbilical endothelial cells and increased production of reactive oxygen and nitrogen species in addition to a transient elevation in the total thiol group content.	Sulfhydryl Compounds	271-276	vascular endothelial growth factor D	Homo sapiens	107-113
28385889-4	2017	Using heterologous expression in Xenopus oocytes and the engineered cysteine-less hCNT3 protein hCNT3(C-), substituted cysteine accessibility method analysis with the membrane-impermeant thiol reactive reagent p-chloromercuribenzene sulfonate was performed on the transport domain (interfacial helix 2, hairpin 1, putative transmembrane domain (TM) 7, and TM8), as well as TM9 of the scaffold domain of the protein.	Sulfhydryl Compounds	187-192	solute carrier family 28 member 3	Homo sapiens	82-87
28442570-4	2017	CblC from Caenorhabditis elegans (ceCblC) also exhibits a robust thiol oxidase activity, converting reduced GSH to oxidized GSSG with concomitant scrubbing of ambient dissolved O2 The mechanism of thiol oxidation catalyzed by ceCblC is not known.	Sulfhydryl Compounds	65-70	Cbl proto-oncogene C	Homo sapiens	0-4
28411237-3	2017	Thioredoxin (Trx) and glutaredoxin (Grx) are ubiquitous redox proteins, catalyzing thiol-disulfide exchange reactions.	Sulfhydryl Compounds	83-88	thioredoxin	Homo sapiens	0-11
28411237-3	2017	Thioredoxin (Trx) and glutaredoxin (Grx) are ubiquitous redox proteins, catalyzing thiol-disulfide exchange reactions.	Sulfhydryl Compounds	83-88	thioredoxin	Homo sapiens	13-16
28411237-3	2017	Thioredoxin (Trx) and glutaredoxin (Grx) are ubiquitous redox proteins, catalyzing thiol-disulfide exchange reactions.	Sulfhydryl Compounds	83-88	glutaredoxin	Homo sapiens	22-34
28411237-3	2017	Thioredoxin (Trx) and glutaredoxin (Grx) are ubiquitous redox proteins, catalyzing thiol-disulfide exchange reactions.	Sulfhydryl Compounds	83-88	glutaredoxin	Homo sapiens	36-39
27662116-6	2017	Catalase activity showed a decrease only in intact liver at -20 and -80 C. In contrast, in blood it showed an increase in intact tissue at -20 and -80 C. Reduced thiol groups generally decreased with freezing time, but showed an increase in intact blood at -20 and -80 C, probably because of color interference.	Sulfhydryl Compounds	162-167	catalase	Rattus norvegicus	0-8
28726203-2	2017	Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker.	Sulfhydryl Compounds	101-106	C-C motif chemokine ligand 2	Homo sapiens	113-134
28726203-2	2017	Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker.	Sulfhydryl Compounds	101-106	mitogen-activated protein kinase kinase 7	Homo sapiens	177-180
28726203-2	2017	Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker.	Sulfhydryl Compounds	101-106	mitogen-activated protein kinase 1	Homo sapiens	181-184
28150308-8	2017	Patient phenotyping failed to detect useful antigen information on eight patients: seven Fyb silencing mutations and one partial e. A thiol-treated RRC antibody investigation was the least expensive testing method for the first transfusion, but four- and five-antigen-matched RBC transfusions were equal in cost within five and 21 transfusion events, respectively.	Sulfhydryl Compounds	134-139	FYN binding protein 1	Homo sapiens	89-92
28127705-10	2017	Vit C increased thiol, SOD and CAT in the brain tissues while, reduced MDA.	Sulfhydryl Compounds	16-21	vitrin	Rattus norvegicus	0-3
28406517-1	2017	Mycothiol (MSH) is the predominant low molecular weight thiol produced by actinomycetes, and it plays a pivotal role in the bacterial detoxication process.	Sulfhydryl Compounds	4-9	msh homeobox 2	Homo sapiens	11-14
28530270-4	2017	Through dual-color 2P-PEEM for various alkyl chain lengths of Cn-SAMs, it is revealed that SPP properties are largely modified by an interfacial electronic state, particularly formed by the chemical interaction between surface Au atoms and adsorbate thiol molecules, thereby allowing the quantification of their group velocity at ~0.86 times the speed of light.	Sulfhydryl Compounds	250-255	methionine adenosyltransferase 1A	Homo sapiens	65-69
28471462-8	2017	Another recently deorphaned human olfactory receptor, OR2M3, highly selective for a thiol from onions, and a broadly-tuned thiol receptor, OR1A1, are also discussed.	Sulfhydryl Compounds	84-89	olfactory receptor family 2 subfamily M member 3	Homo sapiens	54-59
28179112-2	2017	Here we present a novel protein-protein interaction among Glucose-6-phosphate dehydrogenase (LdG6PDH) and Trypanothione reductase (LdTryR) of Leishmania donovani displaying interconnection between central glucose metabolism and thiol metabolism of this parasite.	Sulfhydryl Compounds	228-233	trypanothione reductase	Leishmania donovani	106-129
28464614-3	2017	Spatially resolved core level images of C1s, V2p, and Y3d are obtained, which verify the selective thiol adsorption on the gold squares and specific binding of europium doped yttrium vanadate QDots on the self-assembled monolayer.	Sulfhydryl Compounds	99-104	complement C1s	Homo sapiens	40-43
28390674-6	2017	Assessment of intracellular free sulfhydryl levels and lactate dehydrogenase activity suggested that Cd2+ (10 mumol/L) induced oxidative stress and disrupted cell membrane integrity.	Sulfhydryl Compounds	33-43	Cd2 molecule	Rattus norvegicus	101-104
28087384-3	2017	The terminal thiol group of the EGF fragment was first conjugated to surface amines of the MNPs using a heterofunctional crosslinker, and doxorubicin was sequentially conjugated to the MNPs via a hydrazone linker, where the degree of subsitution of the surface amines to EGFfr was varied from 1% to 40%.	Sulfhydryl Compounds	13-18	epidermal growth factor	Homo sapiens	32-35
28069233-3	2017	Our model protein, bovine serum albumin (BSA) was treated with 2-iminothiolane hydrochloride (Traut"s reagent) to convert primary amines to thiols before the synthesis of microbubbles.	Sulfhydryl Compounds	140-146	albumin	Homo sapiens	26-39
28358192-1	2017	The protein disulfide isomerase (PDI) family comprises a wide set of enzymes mainly involved in thiol-disulfide exchange reactions in the endoplasmic reticulum.	Sulfhydryl Compounds	96-101	protein disulfide isomerase	Arabidopsis thaliana	4-31
28358192-1	2017	The protein disulfide isomerase (PDI) family comprises a wide set of enzymes mainly involved in thiol-disulfide exchange reactions in the endoplasmic reticulum.	Sulfhydryl Compounds	96-101	protein disulfide isomerase	Arabidopsis thaliana	33-36
28063347-1	2017	Mycobacterium tuberculosis has distinctive ability to detoxify various microbicidal superoxides and hydroperoxides via a redox catalytic cycle involving thiol reductants of peroxiredoxin (Prx) and thioredoxin (Trx) systems which has conferred on it resistance against oxidative killing and survivability within host.	Sulfhydryl Compounds	153-158	peroxiredoxin	Mycobacterium tuberculosis H37Rv	173-186
28063347-1	2017	Mycobacterium tuberculosis has distinctive ability to detoxify various microbicidal superoxides and hydroperoxides via a redox catalytic cycle involving thiol reductants of peroxiredoxin (Prx) and thioredoxin (Trx) systems which has conferred on it resistance against oxidative killing and survivability within host.	Sulfhydryl Compounds	153-158	peroxiredoxin	Mycobacterium tuberculosis H37Rv	188-191
28063347-1	2017	Mycobacterium tuberculosis has distinctive ability to detoxify various microbicidal superoxides and hydroperoxides via a redox catalytic cycle involving thiol reductants of peroxiredoxin (Prx) and thioredoxin (Trx) systems which has conferred on it resistance against oxidative killing and survivability within host.	Sulfhydryl Compounds	153-158	thioredoxin	Mycobacterium tuberculosis H37Rv	197-208
28063347-1	2017	Mycobacterium tuberculosis has distinctive ability to detoxify various microbicidal superoxides and hydroperoxides via a redox catalytic cycle involving thiol reductants of peroxiredoxin (Prx) and thioredoxin (Trx) systems which has conferred on it resistance against oxidative killing and survivability within host.	Sulfhydryl Compounds	153-158	thioredoxin	Mycobacterium tuberculosis H37Rv	210-213
28073045-4	2017	The hydrophobic Bp1 peptide with a cysteine residue adsorbs irreversibly onto Au surfaces due to thiol bond formation, while on hydrophobic CH3 SAM surface, the interactions are hydrophobic in nature.	Sulfhydryl Compounds	97-102	BP1	Homo sapiens	16-19
28175305-2	2017	Summary answer: ERp57 is a component of a multimeric spermatozoa-ZP receptor complex involved in regulation of human spermatozoa-ZP binding via up-regulation of sperm surface thiol content.	Sulfhydryl Compounds	175-180	protein disulfide isomerase family A member 3	Homo sapiens	16-21
28175305-19	2017	Blocking of ERp57 function by specific antibody or inhibitors against ERp57 reduced the surface thiol content and ZP-binding capacity of human spermatozoa.	Sulfhydryl Compounds	96-101	protein disulfide isomerase family A member 3	Homo sapiens	12-17
28175305-19	2017	Blocking of ERp57 function by specific antibody or inhibitors against ERp57 reduced the surface thiol content and ZP-binding capacity of human spermatozoa.	Sulfhydryl Compounds	96-101	protein disulfide isomerase family A member 3	Homo sapiens	70-75
28294521-0	2017	Thiol-based copper handling by the copper chaperone Atox1.	Sulfhydryl Compounds	0-5	peroxiredoxin 3	Homo sapiens	52-57
28294521-3	2017	Atox1 and other copper chaperones handle cytosolic copper using Cys thiols which are ideal ligands for coordinating Cu(I).	Sulfhydryl Compounds	68-74	peroxiredoxin 3	Homo sapiens	0-5
28219012-7	2017	RK-quinone and DBL-quinone quantitatively bind to the small thiol N-acetyl-l-cysteine to form thiol adducts and can also bind to the thiol protein bovine serum albumin through its cysteinyl residue.	Sulfhydryl Compounds	60-65	MCF.2 cell line derived transforming sequence	Homo sapiens	15-18
28219012-7	2017	RK-quinone and DBL-quinone quantitatively bind to the small thiol N-acetyl-l-cysteine to form thiol adducts and can also bind to the thiol protein bovine serum albumin through its cysteinyl residue.	Sulfhydryl Compounds	94-99	MCF.2 cell line derived transforming sequence	Homo sapiens	15-18
28262504-5	2017	We identified the conserved cysteine 97 (Cys-97) to be the only reactive thiol in human MCU that undergoes S-glutathionylation.	Sulfhydryl Compounds	73-78	mitochondrial calcium uniporter	Homo sapiens	88-91
28155214-6	2017	DAT inhibition by 3alpha-bis-4-fluorophenyl-methoxytropane and dithiothreitol (a cell-permeable thiol-reducing agent) protected RA-differentiated, but not undifferentiated, SH-SY5Y cells from oxidative damage and cell death caused by 6-OHDA.	Sulfhydryl Compounds	96-101	solute carrier family 6 member 3	Homo sapiens	0-3
28484486-9	2017	Likewise, exposed plants exhibited increased expressions of glutathione synthase and glutathione S-transferase (nearly threefold increase in both roots and leaves), indicating a promising role of thiols in detoxification of TiO2NPs in tomato.	Sulfhydryl Compounds	196-202	glutathione synthetase, chloroplastic	Solanum lycopersicum	60-80
28484486-9	2017	Likewise, exposed plants exhibited increased expressions of glutathione synthase and glutathione S-transferase (nearly threefold increase in both roots and leaves), indicating a promising role of thiols in detoxification of TiO2NPs in tomato.	Sulfhydryl Compounds	196-202	glutathione S-transferase	Solanum lycopersicum	85-110
27825522-2	2017	The thiol modified T-rich hairpin capture probe was self-assembled onto the surface of the NPG modified electrode for hybridizing with ferrocene-labeled T-rich probe in the presence of Hg2+ via T-Hg2+-T coordination chemistry.	Sulfhydryl Compounds	4-9	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	185-188
27825522-2	2017	The thiol modified T-rich hairpin capture probe was self-assembled onto the surface of the NPG modified electrode for hybridizing with ferrocene-labeled T-rich probe in the presence of Hg2+ via T-Hg2+-T coordination chemistry.	Sulfhydryl Compounds	4-9	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	196-199
27825522-4	2017	Taking advantage of the amplification effect of NPG electrode for increasing the reaction sites of thiol modified capture probe, the proposed electrochemical aptasensor could detect Hg2+ quantitatively in the range of 0.01-5000nM, with a detection limit as low as 0.0036nM which is much lower than the maximum contamination level for Hg2+ in drinking water defined by the U.S. Environmental Protection Agency.	Sulfhydryl Compounds	99-104	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	182-185
27825522-4	2017	Taking advantage of the amplification effect of NPG electrode for increasing the reaction sites of thiol modified capture probe, the proposed electrochemical aptasensor could detect Hg2+ quantitatively in the range of 0.01-5000nM, with a detection limit as low as 0.0036nM which is much lower than the maximum contamination level for Hg2+ in drinking water defined by the U.S. Environmental Protection Agency.	Sulfhydryl Compounds	99-104	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	334-337
28177569-0	2017	The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling.	Sulfhydryl Compounds	13-18	catenin beta interacting protein 1	Homo sapiens	86-90
28257787-1	2017	Human protein disulfide isomerase (hPDI) is a key redox-regulated thiol-containing protein operating as both oxidoreductase and molecular chaperone in the endoplasmic reticulum of cells.	Sulfhydryl Compounds	66-71	prolyl 4-hydroxylase subunit beta	Homo sapiens	6-33
28257787-1	2017	Human protein disulfide isomerase (hPDI) is a key redox-regulated thiol-containing protein operating as both oxidoreductase and molecular chaperone in the endoplasmic reticulum of cells.	Sulfhydryl Compounds	66-71	prolyl 4-hydroxylase subunit beta	Homo sapiens	35-39
28257787-1	2017	Human protein disulfide isomerase (hPDI) is a key redox-regulated thiol-containing protein operating as both oxidoreductase and molecular chaperone in the endoplasmic reticulum of cells.	Sulfhydryl Compounds	66-71	thioredoxin reductase 1	Homo sapiens	109-123
28025687-9	2017	Residues were investigated by measuring transport activities, kinetics and response to thiol-specific reagents in 42 site-specific mutants compared with cysteine-less GltP (C256A) having an apparent affinity of initial rate transport (K m) for 3H-L-glutamate of 22.6 +- 5.5 muM in energised E. coli cells.	Sulfhydryl Compounds	87-92	glycolipid transfer protein	Homo sapiens	167-171
27665998-2	2017	Therefore, thioredoxin (Trx) as an antioxidant maintains the balance of the thiol-related redox status, and also plays pivotal roles in the regulation of redox signaling.	Sulfhydryl Compounds	76-81	thioredoxin	Homo sapiens	11-22
27889386-3	2017	PDIA1 exerts thiol oxidation/reduction and isomerization, plus chaperone effects.	Sulfhydryl Compounds	13-18	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-5
27665998-2	2017	Therefore, thioredoxin (Trx) as an antioxidant maintains the balance of the thiol-related redox status, and also plays pivotal roles in the regulation of redox signaling.	Sulfhydryl Compounds	76-81	thioredoxin	Homo sapiens	24-27
27889386-8	2017	Extracellularly, PDIs crucially regulate thiol redox signaling of thrombosis/platelet activation, e.g., integrins, and PDIA1 supports expansive caliber remodeling during injury repair via matrix/cytoskeletal organization.	Sulfhydryl Compounds	41-46	prolyl 4-hydroxylase subunit beta	Homo sapiens	119-124
28131631-8	2017	Either dephosphorylation of RyR2 using PP1 or thiol reduction using DTT eliminated any significant difference in the activity of RyR2 from healthy and failing hearts.	Sulfhydryl Compounds	46-51	ryanodine receptor 2	Homo sapiens	129-133
28511369-10	2017	Thiol levels were decreased in PIH as compared to control (p&lt;0.001).	Sulfhydryl Compounds	0-5	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	31-34
28510123-1	2017	We have shown that the inhibition of Na,K-ATPase during its long-term incubation with amyloid beta (Abeta42), an Alzheimer"s disease protein, is caused by the change in the thiol redox status of cells leading to induction of glutathionylation alpha-subunit of Na,K-ATPase.	Sulfhydryl Compounds	173-178	amyloid beta precursor protein	Homo sapiens	86-98
27876599-6	2017	RESULTS: Generated thiolated Eudragit  S100 displaying 235+-14mumol of free thiol groups and 878+-101mumol of disulfide bonds per gram polymer showed a great improvement in both: dynamic viscosity with mucus and adhesion time on mucosal tissue compared to the unmodified polymer.	Sulfhydryl Compounds	19-24	S100 calcium binding protein A1	Homo sapiens	39-43
28107924-1	2017	Effective covalent immobilization of quinone and aptamer onto a gold electrode via thiol addition (a Michael addition) for sensitive and selective protein (with thrombin as the model) biosensing is reported, with a detection limit down to 20 fM for thrombin.	Sulfhydryl Compounds	83-88	coagulation factor II, thrombin	Homo sapiens	249-257
28007499-11	2017	The effects of CYT-Rx20 on cell viability and the loss of DeltaPsim were significantly reversed when cells were pretreated with thiol antioxidants NAC, GSH, or 2-ME.	Sulfhydryl Compounds	128-133	synuclein alpha	Homo sapiens	147-150
28069892-6	2017	Sulfur deficiency inhibited DCL4 but not DCL3, and the activity of DCL4 was recovered by supplementation of the cell-free extracts with reductants containing a thiol group.	Sulfhydryl Compounds	160-165	dicer-like 4	Arabidopsis thaliana	67-71
28107924-1	2017	Effective covalent immobilization of quinone and aptamer onto a gold electrode via thiol addition (a Michael addition) for sensitive and selective protein (with thrombin as the model) biosensing is reported, with a detection limit down to 20 fM for thrombin.	Sulfhydryl Compounds	83-88	coagulation factor II, thrombin	Homo sapiens	161-169
27193868-0	2017	Synthesis and application of thiol-functionalized magnetic nanoparticles for studying interactions of epirubicin hydrochloride with bovine serum albumin by fluorescence spectrometry.	Sulfhydryl Compounds	29-34	albumin	Homo sapiens	139-152
28107924-2	2017	Briefly, the thiol addition reaction of a gold electrode-supported 1,6-hexanedithiol (HDT) with p-benzoquinone (BQ) yielded BQ-HDT/Au, and the similar reaction of thiolated thrombin aptamer (TTA) with activated BQ-HDT/Au under 0.3V led to formation of a gold electrode-supported novel electrochemical probe TTA-BQ-HDT/Au.	Sulfhydryl Compounds	13-18	coagulation factor II, thrombin	Homo sapiens	173-181
28126440-4	2017	Nrf2 exists in the cytosol in complex with its binding partner Keap1, which is a thiol-rich redox-sensing protein.	Sulfhydryl Compounds	81-86	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
28222608-4	2017	Representatively, the material (COF-S-SH) synthesized by treating COF-V with 1,2-ethanedithiol exhibits high efficiency in removing mercury from aqueous solutions and the air, affording Hg2+ and Hg0 capacities of 1350 and 863 mg g-1, respectively, surpassing all those of thiol and thioether functionalized materials reported thus far.	Sulfhydryl Compounds	89-94	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	32-37
28249157-0	2017	Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II.	Sulfhydryl Compounds	101-106	hydroxyacylglutathione hydrolase	Homo sapiens	133-146
28126440-4	2017	Nrf2 exists in the cytosol in complex with its binding partner Keap1, which is a thiol-rich redox-sensing protein.	Sulfhydryl Compounds	81-86	kelch like ECH associated protein 1	Homo sapiens	63-68
28025393-5	2017	Spermatozoa from infertile men have lower levels of PRDXs (particularly of PRDX6), which are thiol-oxidized and therefore inactive.	Sulfhydryl Compounds	93-98	peroxiredoxin 6	Homo sapiens	75-80
28011619-5	2017	This conjugation event attenuated reversible thiol reduction of Trx1, leading to ROS accumulation and a broader degradation of thiol redox homeostasis in cancer cells.	Sulfhydryl Compounds	45-50	thioredoxin 1	Mus musculus	64-68
28011619-5	2017	This conjugation event attenuated reversible thiol reduction of Trx1, leading to ROS accumulation and a broader degradation of thiol redox homeostasis in cancer cells.	Sulfhydryl Compounds	127-132	thioredoxin 1	Mus musculus	64-68
28198441-4	2017	In vitro thiol reductase assay revealed that PDI increased the amount of thiols on full-length recombinant NR1 protein.	Sulfhydryl Compounds	73-79	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	45-48
28198441-4	2017	In vitro thiol reductase assay revealed that PDI increased the amount of thiols on full-length recombinant NR1 protein.	Sulfhydryl Compounds	73-79	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	107-110
28039148-10	2017	Furthermore, GPx1 knockdown-mediated reductive and oxidative stress could be antagonized by a thiol-oxidizing agent diamide and a thiol-containing compound N-acetylcysteine (NAC), respectively.	Sulfhydryl Compounds	94-99	glutathione peroxidase 1	Mus musculus	13-17
28100875-7	2017	Logistic regression analysis revealed that changes in BNP and global longitudinal strain (GLS), baseline level of native thiol, disulfide, and the disulfide/total thiol ratio were strong predictors for a decrease in LVEF.The thiol/disulfide pathway may be a factor for predicting chemotherapy-induced cardiac toxicity as one of the oxidative stress mechanisms.	Sulfhydryl Compounds	163-168	natriuretic peptide B	Homo sapiens	54-57
28100875-7	2017	Logistic regression analysis revealed that changes in BNP and global longitudinal strain (GLS), baseline level of native thiol, disulfide, and the disulfide/total thiol ratio were strong predictors for a decrease in LVEF.The thiol/disulfide pathway may be a factor for predicting chemotherapy-induced cardiac toxicity as one of the oxidative stress mechanisms.	Sulfhydryl Compounds	163-168	natriuretic peptide B	Homo sapiens	54-57
28039148-10	2017	Furthermore, GPx1 knockdown-mediated reductive and oxidative stress could be antagonized by a thiol-oxidizing agent diamide and a thiol-containing compound N-acetylcysteine (NAC), respectively.	Sulfhydryl Compounds	130-135	glutathione peroxidase 1	Mus musculus	13-17
28152104-0	2017	Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors.	Sulfhydryl Compounds	39-44	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	62-67
28152104-3	2017	Elimination of the thiol function by substitution of serine for Cys-893 led to increased steady-state expression level and strongly reduced interaction with SAP97, a major cytosolic interaction partner of GluA1 C-terminus.	Sulfhydryl Compounds	19-24	discs large MAGUK scaffold protein 1	Homo sapiens	157-162
28152104-3	2017	Elimination of the thiol function by substitution of serine for Cys-893 led to increased steady-state expression level and strongly reduced interaction with SAP97, a major cytosolic interaction partner of GluA1 C-terminus.	Sulfhydryl Compounds	19-24	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	205-210
28152104-6	2017	Our results show that Cys-893 can serve as a molecular target for regulatory thiol modifications of GluA1 receptors, including the effects of nitric oxide.	Sulfhydryl Compounds	77-82	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	100-105
27777179-5	2017	alpha1-antitrypsin, transthyretin, and haptoglobin showed thiol oxidation at HOCl concentrations higher than those causing complete oxidation of albumin.	Sulfhydryl Compounds	58-63	serpin family A member 1	Homo sapiens	0-18
28034831-11	2017	PDIA1 was robustly secreted by physiological levels of arterial laminar shear in EC and supported alpha 5 integrin thiol oxidation.	Sulfhydryl Compounds	115-120	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-5
27777179-5	2017	alpha1-antitrypsin, transthyretin, and haptoglobin showed thiol oxidation at HOCl concentrations higher than those causing complete oxidation of albumin.	Sulfhydryl Compounds	58-63	haptoglobin	Homo sapiens	39-50
27923813-2	2017	Nitro-conjugated linoleic acid (NO2-CLA) is preferentially formed, constitutes the most abundant nitrated fatty acid in humans, and contains two carbons that could potentially react with thiols, modulating signaling actions and levels.	Sulfhydryl Compounds	187-193	selectin P ligand	Homo sapiens	36-39
27923813-3	2017	In this work, we examined the reactions of NO2-CLA with low molecular weight thiols (glutathione, cysteine, homocysteine, cysteinylglycine, and beta-mercaptoethanol) and human serum albumin.	Sulfhydryl Compounds	77-83	selectin P ligand	Homo sapiens	47-50
28075404-15	2017	The cell surface thiols dose dependently decreased following HSA-AOPP treatment, while ROS production increased.	Sulfhydryl Compounds	17-23	peroxiredoxin 5	Mus musculus	65-69
27909052-0	2017	Spontaneous Unfolding-Refolding of Fibronectin Type III Domains Assayed by Thiol Exchange: THERMODYNAMIC STABILITY CORRELATES WITH RATES OF UNFOLDING RATHER THAN FOLDING.	Sulfhydryl Compounds	75-80	fibronectin 1	Homo sapiens	35-46
28075404-0	2017	Advanced Oxidation Protein Products-Modified Albumin Induces Differentiation of RAW264.7 Macrophages into Dendritic-Like Cells Which Is Modulated by Cell Surface Thiols.	Sulfhydryl Compounds	162-168	peroxiredoxin 5	Mus musculus	0-35
27796455-2	2017	A 15-base thrombin-binding aptamer (TBA15) with a thiol end was first immobilized on an Ag nanoprism array by the S-Ag bond.	Sulfhydryl Compounds	50-55	coagulation factor II, thrombin	Homo sapiens	10-18
27982144-1	2017	A novel class of superfluorinated and NIR-luminescent gold nanoclusters were obtained starting from a branched thiol, bearing 27 equivalent 19F atoms per molecule.	Sulfhydryl Compounds	111-116	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	38-41
29047089-2	2017	Nitric oxide, reactive oxygen species, thiol and heme redox, and heme biosynthesis control mechanisms regulating the production of cGMP by sGC.	Sulfhydryl Compounds	39-44	sarcoglycan beta	Homo sapiens	139-142
27796455-2	2017	A 15-base thrombin-binding aptamer (TBA15) with a thiol end was first immobilized on an Ag nanoprism array by the S-Ag bond.	Sulfhydryl Compounds	50-55	S-antigen visual arrestin	Homo sapiens	114-118
26823067-0	2017	In vivo oxidative stress alters thiol redox status of peroxiredoxin 1 and 6 and impairs rat sperm quality.	Sulfhydryl Compounds	32-37	peroxiredoxin 1	Rattus norvegicus	54-75
27834956-9	2017	Consistently, BV6/Dexa treatment causes oxidative thiol modifications of Bak protein.	Sulfhydryl Compounds	50-55	BCL2-antagonist/killer 1	Mus musculus	73-76
27671344-6	2017	The parent compounds herein presented a certain reactivity concerning oxidation and thiol binding: Unsubstituted aminophenols bound covalently to C159 and C418 of human 5-LO.	Sulfhydryl Compounds	84-89	arachidonate 5-lipoxygenase	Homo sapiens	169-173
27064983-1	2017	The study aimed to compare the dynamic thiol/disulfide homeostasis between patients with premature ovarian failure (POF) and healthy women.	Sulfhydryl Compounds	39-44	POF1B actin binding protein	Homo sapiens	116-119
27064983-7	2017	This is the first study demonstrating the thiol/disulfide homeostasis in women with POF and may help us understanding the pathophysiology.	Sulfhydryl Compounds	42-47	POF1B actin binding protein	Homo sapiens	84-87
27774630-6	2017	Furthermore, binding of HMGB1 to AIM2 is stronger with fully reduced all-thiol HMGB1 than with partially oxidized disulfide-HMGB1, and binding strength corresponds to caspase-1 activation.	Sulfhydryl Compounds	73-78	high mobility group box 1	Mus musculus	24-29
28527208-6	2017	Our results underline the necessity of thiol-protecting conditions during the analysis of tau oligomers involved in the etiopathogenesis of various tauopathies including Alzheimer"s disease.	Sulfhydryl Compounds	39-44	microtubule associated protein tau	Homo sapiens	90-93
27774630-6	2017	Furthermore, binding of HMGB1 to AIM2 is stronger with fully reduced all-thiol HMGB1 than with partially oxidized disulfide-HMGB1, and binding strength corresponds to caspase-1 activation.	Sulfhydryl Compounds	73-78	absent in melanoma 2	Mus musculus	33-37
27774630-6	2017	Furthermore, binding of HMGB1 to AIM2 is stronger with fully reduced all-thiol HMGB1 than with partially oxidized disulfide-HMGB1, and binding strength corresponds to caspase-1 activation.	Sulfhydryl Compounds	73-78	high mobility group box 1	Mus musculus	79-84
27774630-6	2017	Furthermore, binding of HMGB1 to AIM2 is stronger with fully reduced all-thiol HMGB1 than with partially oxidized disulfide-HMGB1, and binding strength corresponds to caspase-1 activation.	Sulfhydryl Compounds	73-78	high mobility group box 1	Mus musculus	79-84
28138305-13	2017	Conclusion: The difference in texture and hardness of mucin may be due to cellular content, hydration, glucose, protein, lipids, thiol and MUC distribution.	Sulfhydryl Compounds	129-134	LOC100508689	Homo sapiens	54-59
28500593-8	2017	In the other part reversibly modified PTP-thiols are first reduced and then hyperoxidized by pervanadate (PV).	Sulfhydryl Compounds	42-48	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	38-41
27756843-8	2016	Sirt1 S-nitrosation was reversed upon exposure to the thiol-based reducing agents, including physiologically relevant concentrations of the cellular reducing agent glutathione.	Sulfhydryl Compounds	54-59	sirtuin 1	Homo sapiens	0-5
29118897-9	2017	The transmembrane protein ADAM17 releases proinflammatory mediators, such as TNFalpha, and is itself regulated by a thiol switch.	Sulfhydryl Compounds	116-121	ADAM metallopeptidase domain 17	Homo sapiens	26-32
29118897-9	2017	The transmembrane protein ADAM17 releases proinflammatory mediators, such as TNFalpha, and is itself regulated by a thiol switch.	Sulfhydryl Compounds	116-121	tumor necrosis factor	Homo sapiens	77-85
27348778-4	2016	Alloyed thioglycolic (TGA)-capped CdZnSeS QDs with a high photoluminescence (PL) quantum yield (QY) value of 92% were synthesized, and a modified silanization method was employed to encapsulate the thiol-capped QDs in a silica layer.	Sulfhydryl Compounds	198-203	T-box transcription factor 1	Homo sapiens	22-25
27960420-6	2016	EpCAM antibody was modified onto the surface of the micropillars through the thiol-oligonucleotide linkers in order to release captured cancer cells by DNase I treatment.	Sulfhydryl Compounds	77-82	epithelial cell adhesion molecule	Homo sapiens	0-5
27726203-3	2016	This decrease depends on the electronic nature of the thiols, being most pronounced with highly electron-rich thiols (4-R=NMe2 ).	Sulfhydryl Compounds	54-60	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	122-126
27726203-3	2016	This decrease depends on the electronic nature of the thiols, being most pronounced with highly electron-rich thiols (4-R=NMe2 ).	Sulfhydryl Compounds	110-116	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	122-126
27234646-4	2016	In this study, we studied the modulatory effect of the thiol-rich compound S-allyl cysteine (SAC) on the mRNA level of uroplakin II by real-time polymerase chain reaction and expression of uroplakin II protein by immunoblotting.	Sulfhydryl Compounds	55-60	uroplakin 2	Mus musculus	119-131
27934335-0	2016	Enantioselective Synthesis of alpha-Mercapto-beta-amino Esters via Rh(II)/Chiral Phosphoric Acid-Cocatalyzed Three-Component Reaction of Diazo Compounds, Thiols, and Imines.	Sulfhydryl Compounds	154-160	Rh blood group D antigen	Homo sapiens	67-73
27638861-0	2016	Alkylating Agent-Induced NRF2 Blocks Endoplasmic Reticulum Stress-Mediated Apoptosis via Control of Glutathione Pools and Protein Thiol Homeostasis.	Sulfhydryl Compounds	130-135	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
28451143-2	2016	One such example is the inactivation of ubiquitin specific protease-2 (USP2)-an emerging drug target to combat prostate cancer-by beta-lapachone, which has been identified to involve oxidation of the catalytic cysteine"s thiol residue to sulfinic acid.	Sulfhydryl Compounds	221-226	ubiquitin specific peptidase 2	Homo sapiens	40-69
28451143-2	2016	One such example is the inactivation of ubiquitin specific protease-2 (USP2)-an emerging drug target to combat prostate cancer-by beta-lapachone, which has been identified to involve oxidation of the catalytic cysteine"s thiol residue to sulfinic acid.	Sulfhydryl Compounds	221-226	ubiquitin specific peptidase 2	Homo sapiens	71-75
27671770-14	2016	In the presence of MnTE-2-PyP, there was a significant increase in oxidized thiols in PC3 cell lysates and this was reversed with catalase overexpression.	Sulfhydryl Compounds	76-82	catalase	Homo sapiens	130-138
27671770-15	2016	Specifically, we showed that p300 was oxidized after MnTE-2-PyP treatment, indicating that MnTE-2-PyP is creating a more oxidizing environment and this is altering the oxidation state of p300 thiol residues.	Sulfhydryl Compounds	192-197	E1A binding protein p300	Homo sapiens	29-33
27671770-15	2016	Specifically, we showed that p300 was oxidized after MnTE-2-PyP treatment, indicating that MnTE-2-PyP is creating a more oxidizing environment and this is altering the oxidation state of p300 thiol residues.	Sulfhydryl Compounds	192-197	E1A binding protein p300	Homo sapiens	187-191
27720842-5	2016	MyD88 cysteine residues functionally modulate MyD88-dependent NF-kappaB activation, suggesting a link between MyD88 thiol oxidation state and immune signaling.	Sulfhydryl Compounds	116-121	MYD88 innate immune signal transduction adaptor	Homo sapiens	0-5
27720842-5	2016	MyD88 cysteine residues functionally modulate MyD88-dependent NF-kappaB activation, suggesting a link between MyD88 thiol oxidation state and immune signaling.	Sulfhydryl Compounds	116-121	MYD88 innate immune signal transduction adaptor	Homo sapiens	46-51
27720842-5	2016	MyD88 cysteine residues functionally modulate MyD88-dependent NF-kappaB activation, suggesting a link between MyD88 thiol oxidation state and immune signaling.	Sulfhydryl Compounds	116-121	nuclear factor kappa B subunit 1	Homo sapiens	62-71
27720842-5	2016	MyD88 cysteine residues functionally modulate MyD88-dependent NF-kappaB activation, suggesting a link between MyD88 thiol oxidation state and immune signaling.	Sulfhydryl Compounds	116-121	MYD88 innate immune signal transduction adaptor	Homo sapiens	46-51
27512925-3	2016	The primary role of GGT is the extracellular catabolism of glutathione, the major thiol antioxidant in mammalian cells, which plays a relevant role in protecting cells against oxidants produced during normal metabolism; GGT, therefore, plays an important role in cellular defence.	Sulfhydryl Compounds	82-87	gamma-glutamyltransferase light chain family member 3	Homo sapiens	20-23
27667125-8	2016	This can be an important advantage in terms of reactivity (thiolate/selenolate are more nucleophilic than thiol/selenol) and ability to work as an electrostatic trigger (the "shuttle" mechanism) and may be the reason why TrxR uses selenium instead of sulfur.	Sulfhydryl Compounds	59-64	peroxiredoxin 5	Homo sapiens	221-225
27255146-7	2016	Moreover, PRP increased the levels of enzymatic antioxidants superoxide dismutase and catalase activities in the injured muscle, and also the non-protein thiols (-SH) group levels in erythrocytes.	Sulfhydryl Compounds	154-160	proline rich protein 2-like 1	Rattus norvegicus	10-13
29624354-0	2016	[Intracellular thiol contents and fatty acid metabolism pathways are regulated by the Nrf1 (NFE2L1) with its transcriptional suppressor activity].	Sulfhydryl Compounds	15-20	nuclear respiratory factor 1	Homo sapiens	86-90
27769451-2	2016	Our biosensing approach provides an especial and significant detection mechanism: CS can catalyze the essential condensation reaction between acetyl-coenzyme A (Ac-CoA) and oxaloacetate (OAA) to form citrate and CoA; then, in the presence of Ag(I), CoA-Ag(I) CP can be in situ formed because of the strong complexation ability of thiol groups of CoA toward Ag(I).	Sulfhydryl Compounds	330-335	citrate synthase	Homo sapiens	82-84
29624354-0	2016	[Intracellular thiol contents and fatty acid metabolism pathways are regulated by the Nrf1 (NFE2L1) with its transcriptional suppressor activity].	Sulfhydryl Compounds	15-20	NFE2 like bZIP transcription factor 1	Homo sapiens	92-98
28138537-4	2016	The predicted and verified Ag(SR)3 monomer, together with the recently discovered Ag2(SR)5 dimer and Ag3(SR)6 trimer, establishes a family of unique mount motifs for silver thiolate nanoparticles, expanding knowledge beyond the earlier-known Au-S staples in thiol-capped gold nanoclusters.	Sulfhydryl Compounds	173-178	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	82-85
28138537-4	2016	The predicted and verified Ag(SR)3 monomer, together with the recently discovered Ag2(SR)5 dimer and Ag3(SR)6 trimer, establishes a family of unique mount motifs for silver thiolate nanoparticles, expanding knowledge beyond the earlier-known Au-S staples in thiol-capped gold nanoclusters.	Sulfhydryl Compounds	173-178	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	101-104
30108705-0	2017	Discovery of selective cystathionine beta-synthase inhibitors by high-throughput screening with a fluorescent thiol probe.	Sulfhydryl Compounds	110-115	cystathionine beta-synthase	Homo sapiens	23-50
27634040-0	2016	Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch.	Sulfhydryl Compounds	80-85	lysine demethylase 1A	Homo sapiens	60-65
27634040-3	2016	Here, we show KDM1A is highly thiol-reactive in vitro and in cellular models.	Sulfhydryl Compounds	30-35	lysine demethylase 1A	Homo sapiens	14-19
27634040-5	2016	Hydrogen peroxide produced by KDM1A catalysis reduces thiol labeling and inactivates demethylase activity over time.	Sulfhydryl Compounds	54-59	lysine demethylase 1A	Homo sapiens	30-35
27827892-2	2016	Glutaredoxin 1 (Grx1) is a thiol repair enzyme which catalyzes the reduction of PSSG.	Sulfhydryl Compounds	27-32	glutaredoxin	Homo sapiens	0-14
27703014-3	2016	Because excessive thiol oxidation and H2O2 generation cause cell death, Ero1alpha activity must be properly regulated.	Sulfhydryl Compounds	18-23	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	72-81
27827892-2	2016	Glutaredoxin 1 (Grx1) is a thiol repair enzyme which catalyzes the reduction of PSSG.	Sulfhydryl Compounds	27-32	glutaredoxin	Homo sapiens	16-20
27693243-4	2016	BITC-induced cell death was completely prevented by pretreatment with thiol-containing redox compounds including N-acetyl-l-cysteine (NAC), glutathione (GSH), dithiothreitol, and 2-mercaptoethanol, but not free radical scavengers mito-TEMPO, catalase, apocynin, l-NAME and mannitol.	Sulfhydryl Compounds	70-75	X-linked Kx blood group	Homo sapiens	134-137
27612966-0	2016	Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR.	Sulfhydryl Compounds	13-18	dual oxidase 1	Mus musculus	120-125
27612966-0	2016	Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR.	Sulfhydryl Compounds	13-18	epidermal growth factor receptor	Mus musculus	130-134
27612966-5	2016	Acrolein and other thiol-reactive electrophiles were found to dramatically prevent allergen-induced activation of DUOX1 as well as EGFR, and acrolein was capable of inhibiting EGFR tyrosine kinase activity via modification of C797.	Sulfhydryl Compounds	19-24	dual oxidase 1	Mus musculus	114-119
27612966-5	2016	Acrolein and other thiol-reactive electrophiles were found to dramatically prevent allergen-induced activation of DUOX1 as well as EGFR, and acrolein was capable of inhibiting EGFR tyrosine kinase activity via modification of C797.	Sulfhydryl Compounds	19-24	epidermal growth factor receptor	Mus musculus	131-135
27612966-7	2016	Collectively, our findings indicate a novel anti-inflammatory mechanism of CS-derived acrolein and other thiol-reactive electrophiles, by directly inhibiting DUOX1- and EGFR-mediated airway epithelial responses to airborne allergens.	Sulfhydryl Compounds	105-110	dual oxidase 1	Mus musculus	158-163
27612966-7	2016	Collectively, our findings indicate a novel anti-inflammatory mechanism of CS-derived acrolein and other thiol-reactive electrophiles, by directly inhibiting DUOX1- and EGFR-mediated airway epithelial responses to airborne allergens.	Sulfhydryl Compounds	105-110	epidermal growth factor receptor	Mus musculus	169-173
27575053-9	2016	Thiols that were exposed in FXI after PDI reduction were labeled with 3-(N-maleimidopropionyl)-biocytin (MPB) and detected with avidin.	Sulfhydryl Compounds	0-6	prolyl 4-hydroxylase subunit beta	Homo sapiens	38-41
27663261-7	2016	SSNO--induced Nrf2 transactivation activity was abrogated by either NO scavenging with cPTIO or inhibition of thiol sulfuration by high concentrations of cysteine, implying a role for both persulfides/polysulfides and NO in SSNO- mediated Nrf2 activation.	Sulfhydryl Compounds	110-115	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
28123399-2	2016	There are two opposite "chemical" mechanisms underlying such activation: the first one is a non-specific covalent modification of Keap1 thiols, resulting in side effects of varied severity, and the second one is the shift of the Nrf2-Kelch-like ECH associated protein-1 (Keap1) binding equilibrium in the presence of a competitive and chemically benign displacement agent.	Sulfhydryl Compounds	136-142	kelch like ECH associated protein 1	Homo sapiens	130-135
28123399-3	2016	At this point, no displacement activators exhibit sufficient biological activity in comparison with common Nrf2 activators working via Keap1 thiol modification.	Sulfhydryl Compounds	141-146	NFE2 like bZIP transcription factor 2	Homo sapiens	107-111
28123399-3	2016	At this point, no displacement activators exhibit sufficient biological activity in comparison with common Nrf2 activators working via Keap1 thiol modification.	Sulfhydryl Compounds	141-146	kelch like ECH associated protein 1	Homo sapiens	135-140
27077456-0	2016	Thiol/disulphide homeostasis in pregnant women with Familial Mediterranean fever.	Sulfhydryl Compounds	0-5	MEFV innate immuity regulator, pyrin	Homo sapiens	52-80
26865084-7	2016	CRP levels in plasma were positively correlated with the body mass index (BMI), insulin and glucose levels, HOMA-IR, HOMA-beta, WBC and neutrophil counts, and the NLR, and were negatively correlated with TAS and total thiol levels in the overall studied population.	Sulfhydryl Compounds	218-223	C-reactive protein	Homo sapiens	0-3
27077456-1	2016	OBJECTIVE: To investigate the presence of oxidative stress (OS) in pregnant women with Familial Mediterranean fever (FMF) in the first trimester by evaluating thiol/disulphide homeostasis.	Sulfhydryl Compounds	159-164	MEFV innate immuity regulator, pyrin	Homo sapiens	117-120
27591652-2	2016	The Mn-doped CdS was deposited on the TiO2 NWs by successive ion layer adsorption and reaction (SILAR) as ECL emitter, on which thiol-modified aptamer of cyt c was attached via Cd-S bond.	Sulfhydryl Compounds	128-133	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
27591652-2	2016	The Mn-doped CdS was deposited on the TiO2 NWs by successive ion layer adsorption and reaction (SILAR) as ECL emitter, on which thiol-modified aptamer of cyt c was attached via Cd-S bond.	Sulfhydryl Compounds	128-133	cytochrome c, somatic	Homo sapiens	154-159
27591652-2	2016	The Mn-doped CdS was deposited on the TiO2 NWs by successive ion layer adsorption and reaction (SILAR) as ECL emitter, on which thiol-modified aptamer of cyt c was attached via Cd-S bond.	Sulfhydryl Compounds	128-133	CDP-diacylglycerol synthase 1	Homo sapiens	177-181
27666483-4	2016	HSA possesses a free thiol group in Cys-34 that could be a site for hydropersulfide formation.	Sulfhydryl Compounds	21-26	albumin	Homo sapiens	0-3
27723317-5	2016	The high utility of alkylative elimination, which is compatible with multiple thiols in Ub targets, was demonstrated by generating a probe derived from the Ub ligase tripartite motif protein 25 (TRIM-25).	Sulfhydryl Compounds	78-84	tripartite motif containing 25	Homo sapiens	166-193
27723317-5	2016	The high utility of alkylative elimination, which is compatible with multiple thiols in Ub targets, was demonstrated by generating a probe derived from the Ub ligase tripartite motif protein 25 (TRIM-25).	Sulfhydryl Compounds	78-84	tripartite motif containing 25	Homo sapiens	195-202
27659093-0	2016	Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols.	Sulfhydryl Compounds	114-120	olfactory receptor family 2 subfamily T member 11	Homo sapiens	83-89
27512054-9	2016	In contrast with RcCDPK1, which catalyzes inhibitory phosphorylation of COS bacterial-type phosphoenolpyruvate carboxylase at Ser451, RcCDPK2 exhibited broad substrate specificity, a wide pH-activity profile centered at pH 8.5, and insensitivity to metabolite effectors or thiol redox status.	Sulfhydryl Compounds	273-278	calcium-dependent protein kinase 26	Ricinus communis	134-141
27521706-4	2016	In this study, a dual-targeting hybrid peptide HAIYPRHGGCGMPKKKPTPIQLNP (T10-ERK), which is composed of ERK peptide inhibitor MPKKKPTPIQLNP, a thiol spacer (i.e., GGCG) and transferrin receptor (TfR)-binding peptide HAIYPRH, was designed.	Sulfhydryl Compounds	143-148	mitogen-activated protein kinase 1	Mus musculus	77-80
27521706-5	2016	Then, this thiol-modified hybrid peptide was conjugated to DOXO-EMCH (6-maleimidocaproyl) hydrazone of DOX), forming a novel peptide-DOX conjugate T10-ERK-DOX.	Sulfhydryl Compounds	11-16	mitogen-activated protein kinase 1	Mus musculus	151-154
27676265-4	2016	Here we show that the penultimate step in the biosynthesis of the highly brominated marine bacterial product pentabromopseudilin is catalyzed by an unusual debrominase Bmp8 that utilizes a redox thiol mechanism to remove the C-2 bromine atom of 2,3,4,5-tetrabromopyrrole to facilitate oxidative coupling to 2,4-dibromophenol.	Sulfhydryl Compounds	195-200	bone morphogenetic protein 8b	Homo sapiens	168-172
27676265-4	2016	Here we show that the penultimate step in the biosynthesis of the highly brominated marine bacterial product pentabromopseudilin is catalyzed by an unusual debrominase Bmp8 that utilizes a redox thiol mechanism to remove the C-2 bromine atom of 2,3,4,5-tetrabromopyrrole to facilitate oxidative coupling to 2,4-dibromophenol.	Sulfhydryl Compounds	195-200	complement C2	Homo sapiens	225-228
27637085-5	2016	DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase.	Sulfhydryl Compounds	248-253	dual oxidase 2	Homo sapiens	0-5
27637085-5	2016	DUOX2 knockdown with short interfering RNA significantly decreased IFN-gamma-induced VEGF-A or HIF-1alpha up-regulation, as did treatment of pancreatic cancer cells with the NADPH oxidase inhibitor diphenylene iodonium, the multifunctional reduced thiol N-acetylcysteine, and the polyethylene glycol-modified form of the hydrogen peroxide detoxifying enzyme catalase.	Sulfhydryl Compounds	248-253	interferon gamma	Homo sapiens	67-76
27789946-0	2016	Real-time colorimetric detection of DNA methylation of the PAX1 gene in cervical scrapings for cervical cancer screening with thiol-labeled PCR primers and gold nanoparticles.	Sulfhydryl Compounds	126-131	paired box 1	Homo sapiens	59-63
27659093-10	2016	When screened against a series of alcohols, thiols, sulfides, and metal-coordinating ligands, OR2T11 responds with enhancement by copper to the mouse semiochemical CH3SCH2SH and derivatives, to four-membered cyclic sulfide thietane and to one- to four-carbon straight- and branched-chain and five-carbon branched-chain thiols but not to longer chain thiols, suggesting compact receptor dimensions.	Sulfhydryl Compounds	44-50	olfactory receptor family 2 subfamily T member 11	Homo sapiens	94-100
27659093-10	2016	When screened against a series of alcohols, thiols, sulfides, and metal-coordinating ligands, OR2T11 responds with enhancement by copper to the mouse semiochemical CH3SCH2SH and derivatives, to four-membered cyclic sulfide thietane and to one- to four-carbon straight- and branched-chain and five-carbon branched-chain thiols but not to longer chain thiols, suggesting compact receptor dimensions.	Sulfhydryl Compounds	319-325	olfactory receptor family 2 subfamily T member 11	Homo sapiens	94-100
27659093-10	2016	When screened against a series of alcohols, thiols, sulfides, and metal-coordinating ligands, OR2T11 responds with enhancement by copper to the mouse semiochemical CH3SCH2SH and derivatives, to four-membered cyclic sulfide thietane and to one- to four-carbon straight- and branched-chain and five-carbon branched-chain thiols but not to longer chain thiols, suggesting compact receptor dimensions.	Sulfhydryl Compounds	319-325	olfactory receptor family 2 subfamily T member 11	Homo sapiens	94-100
27766046-5	2016	The main allosteric disulphide bond in the fifth domain of beta2GPI can exist in two redox states: free thiol or oxidised.	Sulfhydryl Compounds	104-109	apolipoprotein H	Homo sapiens	59-67
27209521-7	2016	The reduced Cd tolerance in sid2 mutants is due to the lowered GSH status, which is associated with the decreased expression of serine acetyltransferase along with a decline in contents of non-protein thiols, phytochelatins, and the lowered transcription and activities of glutathione reductase1 (GR1) which reduced GSH regeneration.	Sulfhydryl Compounds	201-207	ADC synthase superfamily protein	Arabidopsis thaliana	28-32
27642162-0	2016	Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.	Sulfhydryl Compounds	91-96	endoplasmic reticulum protein 44	Homo sapiens	25-30
27642162-0	2016	Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention.	Sulfhydryl Compounds	91-96	peroxiredoxin 4	Homo sapiens	31-46
27642162-4	2016	Our data reveal that ERp44 binds the oxidized form of peroxiredoxin 4 via thiol-disulfide interchange reactions.	Sulfhydryl Compounds	74-79	endoplasmic reticulum protein 44	Homo sapiens	21-26
27642162-4	2016	Our data reveal that ERp44 binds the oxidized form of peroxiredoxin 4 via thiol-disulfide interchange reactions.	Sulfhydryl Compounds	74-79	peroxiredoxin 4	Homo sapiens	54-69
27766046-6	2016	It is the conformational transformation of beta2GPI from its free thiol form to its more immunogenic oxidised form that exposes neo-epitopes on the first and fifth domains.	Sulfhydryl Compounds	66-71	apolipoprotein H	Homo sapiens	43-51
27521458-5	2016	Coupling with sequential blocking of free thiols with multiple iodoacetyl-based Cys-reactive chemicals, we employed this PAC-switch method to show that endogenous SHP-2 and PTP1B were S-nitrosylated in MS-1 cells exposed to insulin.	Sulfhydryl Compounds	42-48	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	163-168
27642162-7	2016	This work provides insights into the mechanisms of thiol-mediated protein retention and indicates the key roles of ERp44 in this biochemical cycle to optimize oxidative folding and redox homeostasis.	Sulfhydryl Compounds	51-56	endoplasmic reticulum protein 44	Homo sapiens	115-120
27422341-2	2016	In the present study, we investigate the selective oxidation/reduction of the protein motif Cys-(Xn=2-6)-Cys, known as a vicinal thiol group (VTG), present in the SR Ca(2+)-ATPase (SERCA) and in the Ca(2+)-channel ryanodine receptor (RyR) which are modified during muscle fatigue in SM.	Sulfhydryl Compounds	129-134	ryanodine receptor 2	Rattus norvegicus	214-232
27422341-2	2016	In the present study, we investigate the selective oxidation/reduction of the protein motif Cys-(Xn=2-6)-Cys, known as a vicinal thiol group (VTG), present in the SR Ca(2+)-ATPase (SERCA) and in the Ca(2+)-channel ryanodine receptor (RyR) which are modified during muscle fatigue in SM.	Sulfhydryl Compounds	129-134	ryanodine receptor 2	Rattus norvegicus	234-237
27888590-12	2016	Protein sulfhydryl showed changes in NTX+CCl4 group which indicated a significant increase in protein sulfhydryl content in a 6th week compared to CCl4 group (P&lt;0.05).	Sulfhydryl Compounds	8-18	C-C motif chemokine ligand 4	Rattus norvegicus	41-45
27521458-5	2016	Coupling with sequential blocking of free thiols with multiple iodoacetyl-based Cys-reactive chemicals, we employed this PAC-switch method to show that endogenous SHP-2 and PTP1B were S-nitrosylated in MS-1 cells exposed to insulin.	Sulfhydryl Compounds	42-48	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	173-178
27529405-0	2016	6-Bromo-7-hydroxy-3-methylcoumarin (mBhc) is an efficient multi-photon labile protecting group for thiol caging and three-dimensional chemical patterning.	Sulfhydryl Compounds	99-104	PHD finger protein 21A	Mus musculus	36-40
27598034-9	2016	Pretreatment with thiol reducing agents blunted 15d-PGJ2-induced HIF-1alpha stabilization, indicative of a cysteine residue as a direct target of 15d-PGJ2.	Sulfhydryl Compounds	18-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
27643875-8	2016	These results indicate that combined inhibition of GSH- and Trx-dependent thiol metabolism using pharmacologically relevant agents can enhance responses of human breast cancer stem cells to radiation both in vitro and in vivo.	Sulfhydryl Compounds	74-79	thioredoxin	Homo sapiens	60-63
27639450-4	2016	Numerous in vitro approaches have identified Trx1-dependent thiol switches; however, these findings may not be physiologically relevant and little is known about Trx1 interactions in vivo.	Sulfhydryl Compounds	60-65	thioredoxin 1	Mus musculus	45-49
26247355-2	2016	In this study restricted chalcone analogue, compound 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one MT1, was used as a starting compound to synthesize new mono Mannich bases since Mannich bases may induce more cytotoxicity than chalcone analogue that they are derived from by producing additional alkylating center for cellular thiols.	Sulfhydryl Compounds	329-335	metallothionein 1I, pseudogene	Homo sapiens	101-104
27350580-3	2016	Here, we demonstrate that the selective oxidations of protein vicinal thiols, occurring only in the more oxidized brains under study, were linked specifically to a peroxide stress as evidenced by increased oxidations, to disulfides, of the presumed catalytic vicinal thiols of peroxiredoxins 1 and 2.	Sulfhydryl Compounds	70-76	peroxiredoxin 1	Rattus norvegicus	277-299
27643875-1	2016	The goal of this study was to determine if depletion of glutathione (GSH) and inhibition of thioredoxin (Trx) reductase (TrxR) activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol-dependent oxidative stress.	Sulfhydryl Compounds	229-234	thioredoxin	Homo sapiens	92-103
27643875-1	2016	The goal of this study was to determine if depletion of glutathione (GSH) and inhibition of thioredoxin (Trx) reductase (TrxR) activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol-dependent oxidative stress.	Sulfhydryl Compounds	229-234	thioredoxin	Homo sapiens	105-108
27405778-2	2016	Previous studies documented metabolic reprogramming in stored red blood cells (RBCs) and oxidation of GAPDH at functional residues upon exposure to pro-oxidants diamide and H2O2 Here we hypothesize that routine storage of erythrocyte concentrates promotes metabolic modulation of stored RBCs by targeting functional thiol residues of GAPDH.	Sulfhydryl Compounds	316-321	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	102-107
27529405-5	2016	To address this issue, here we describe the development of 6-bromo-7-hydroxy-3-methylcoumarin-4-ylmethyl (mBhc) as an improved group for thiol-protection.	Sulfhydryl Compounds	137-142	PHD finger protein 21A	Mus musculus	106-110
27529405-6	2016	One- and two-photon photolysis reactions demonstrate that a peptide containing a mBhc-caged thiol undergoes clean and efficient photo-cleavage upon irradiation without detectable photoisomer production.	Sulfhydryl Compounds	92-97	PHD finger protein 21A	Mus musculus	81-85
27529405-7	2016	To test its utility for biological studies, a K-Ras-derived peptide containing an mBhc-protected thiol was prepared by solid phase peptide synthesis using Fmoc-Cys(mBhc)-OH for the introduction of the caged thiol.	Sulfhydryl Compounds	97-102	KRAS proto-oncogene, GTPase	Homo sapiens	46-51
27529405-7	2016	To test its utility for biological studies, a K-Ras-derived peptide containing an mBhc-protected thiol was prepared by solid phase peptide synthesis using Fmoc-Cys(mBhc)-OH for the introduction of the caged thiol.	Sulfhydryl Compounds	97-102	PHD finger protein 21A	Mus musculus	82-86
27529405-7	2016	To test its utility for biological studies, a K-Ras-derived peptide containing an mBhc-protected thiol was prepared by solid phase peptide synthesis using Fmoc-Cys(mBhc)-OH for the introduction of the caged thiol.	Sulfhydryl Compounds	207-212	KRAS proto-oncogene, GTPase	Homo sapiens	46-51
27529405-11	2016	The simple synthesis of mBhc and its efficient removal by one- and two-photon processes make it an attractive protecting group for thiol caging in a variety of applications.	Sulfhydryl Compounds	131-136	PHD finger protein 21A	Mus musculus	24-28
27131996-1	2016	This manuscript reports the synthesis of pyrene-based fluorescent probe (PA-1) containing alpha,beta-unsaturated carbonyl moiety and its application towards the selective and sensitive detection of cysteine (Cys) over other bio-thiols.	Sulfhydryl Compounds	228-234	PAXIP1 associated glutamate rich protein 1	Homo sapiens	73-77
27517529-4	2016	Thiol end-modified HA was site-specifically conjugated to N-glycan on Fc region of oxidized DR5 Ab using a heterobifunctional linker of 3-(2-pyridyldithio)propionyl hydrazide (PDPH).	Sulfhydryl Compounds	0-5	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	92-95
27449092-3	2016	Pyrrolidine dithiocarbamate (PDTC) is a thiol compound having anti-inflammatory and antioxidant properties which can inhibit STAT3 and nuclear factor kappaB (NF-kappaB) signaling in mice.	Sulfhydryl Compounds	40-45	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
27624281-0	2016	Thiol dependent intramolecular locking of Orai1 channels.	Sulfhydryl Compounds	0-5	ORAI calcium release-activated calcium modulator 1	Homo sapiens	42-47
27530744-6	2016	Cysteine (Cys), glutathione (GSH), and four other kinds of thiols have been well distinguished on the basis of this sensor array at a low concentration (1.0 muM).	Sulfhydryl Compounds	59-65	latexin	Homo sapiens	157-160
27394177-1	2016	Non-esterified fatty acids bound to the human serum albumin (HSA) contribute to several HSAs properties of special concern in pathologies, for instance to the reactivity of the free HSA-Cys34 thiol group (important antioxidative thiol pool in plasma), and to the affinity for binding of molecules and ions (for example cobalt as a prominent biomarker in heart ischemia).	Sulfhydryl Compounds	192-197	albumin	Homo sapiens	46-59
27394177-1	2016	Non-esterified fatty acids bound to the human serum albumin (HSA) contribute to several HSAs properties of special concern in pathologies, for instance to the reactivity of the free HSA-Cys34 thiol group (important antioxidative thiol pool in plasma), and to the affinity for binding of molecules and ions (for example cobalt as a prominent biomarker in heart ischemia).	Sulfhydryl Compounds	229-234	albumin	Homo sapiens	46-59
27035878-2	2016	The oxidoreductase glutaredoxin-1 (Glrx1) under physiological conditions catalyzes deglutathionylation and restores the protein thiol group.	Sulfhydryl Compounds	128-133	glutaredoxin	Mus musculus	19-33
27422983-9	2016	Avoiding the reperfusion-induced thiol oxidation of RyR2 with MPG produced a reduction in the number of arrhythmias and did not modify the contractile recovery.	Sulfhydryl Compounds	33-38	ryanodine receptor 2, cardiac	Mus musculus	52-56
27422983-9	2016	Avoiding the reperfusion-induced thiol oxidation of RyR2 with MPG produced a reduction in the number of arrhythmias and did not modify the contractile recovery.	Sulfhydryl Compounds	33-38	N-methylpurine-DNA glycosylase	Mus musculus	62-65
27035878-2	2016	The oxidoreductase glutaredoxin-1 (Glrx1) under physiological conditions catalyzes deglutathionylation and restores the protein thiol group.	Sulfhydryl Compounds	128-133	glutaredoxin	Mus musculus	35-40
27378569-5	2016	The mean serum free thiol concentration was 3.6+-0.5muM/g protein.	Sulfhydryl Compounds	20-25	latexin	Homo sapiens	52-55
25884239-9	2016	In this study, the probe for hnRNPB1 was designed with a thiol crosslinker.	Sulfhydryl Compounds	57-62	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	29-36
27197195-5	2016	Mechanistic investigations revealed that coinhibition of mTORC1 and GCLC decreased the level of the intracellular thiol antioxidant glutathione (GSH), thereby increasing levels of reactive oxygen species, which we determined to mediate cell death in Tsc2-deficient cells.	Sulfhydryl Compounds	114-119	CREB regulated transcription coactivator 1	Mus musculus	57-63
32263467-4	2016	Inorganic pyrophosphatase (PPase) was conjugated through a one-step thiol-disulfide exchange reaction with a series of well-defined and molecular weight-controlled glycopolymers, poly(2-methacrylamido glucopyranose) (PMAG), prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization.	Sulfhydryl Compounds	68-73	inorganic pyrophosphatase 1	Homo sapiens	0-25
32263467-4	2016	Inorganic pyrophosphatase (PPase) was conjugated through a one-step thiol-disulfide exchange reaction with a series of well-defined and molecular weight-controlled glycopolymers, poly(2-methacrylamido glucopyranose) (PMAG), prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization.	Sulfhydryl Compounds	68-73	inorganic pyrophosphatase 1	Homo sapiens	27-32
27490699-3	2016	In contrast, here we demonstrate that incubation of busulfan with the thiol redox proteins glutaredoxin or thioredoxin at pH 7.4 and 37  C results in the formation of putative S-tetrahydrothiophenium adducts at their catalytic Cys residues, followed by beta-elimination to yield dehydroalanine.	Sulfhydryl Compounds	70-75	glutaredoxin	Homo sapiens	91-103
27490699-3	2016	In contrast, here we demonstrate that incubation of busulfan with the thiol redox proteins glutaredoxin or thioredoxin at pH 7.4 and 37  C results in the formation of putative S-tetrahydrothiophenium adducts at their catalytic Cys residues, followed by beta-elimination to yield dehydroalanine.	Sulfhydryl Compounds	70-75	thioredoxin	Homo sapiens	107-118
27574401-1	2016	BACKGROUND: The glyoxalase system including two thiol-dependent enzymes, glyoxalase I (Glo-I) and glyoxalase II, plays an important role in a ubiquitous metabolic pathway involved in cellular detoxification of cytotoxic 2-oxoaldehydes.	Sulfhydryl Compounds	48-53	glyoxalase I	Homo sapiens	73-85
27574401-1	2016	BACKGROUND: The glyoxalase system including two thiol-dependent enzymes, glyoxalase I (Glo-I) and glyoxalase II, plays an important role in a ubiquitous metabolic pathway involved in cellular detoxification of cytotoxic 2-oxoaldehydes.	Sulfhydryl Compounds	48-53	glyoxalase I	Homo sapiens	87-92
27574401-1	2016	BACKGROUND: The glyoxalase system including two thiol-dependent enzymes, glyoxalase I (Glo-I) and glyoxalase II, plays an important role in a ubiquitous metabolic pathway involved in cellular detoxification of cytotoxic 2-oxoaldehydes.	Sulfhydryl Compounds	48-53	hydroxyacylglutathione hydrolase	Homo sapiens	98-111
27388689-6	2016	This method involves the use of AgNO3 in acidic ethanol to cleave the thiol linkage of pyrrole-protein (DHP-protein) adducts, and the resulting 7,9-di-C2H5O-DHP is quantified by HPLC-ES-MS/MS multiple reaction monitoring analysis in the presence of a known quantity of isotopically labeled 7,9-di-C2D5O-DHP internal standard.	Sulfhydryl Compounds	70-75	5'-3' exoribonuclease 2	Homo sapiens	104-115
27197195-5	2016	Mechanistic investigations revealed that coinhibition of mTORC1 and GCLC decreased the level of the intracellular thiol antioxidant glutathione (GSH), thereby increasing levels of reactive oxygen species, which we determined to mediate cell death in Tsc2-deficient cells.	Sulfhydryl Compounds	114-119	glutamate-cysteine ligase catalytic subunit	Homo sapiens	68-72
27284000-0	2016	Exploring the arachidonic acid-induced structural changes in phagocyte NADPH oxidase p47(phox) and p67(phox) via thiol accessibility and SRCD spectroscopy.	Sulfhydryl Compounds	113-118	pleckstrin	Homo sapiens	103-107
27526200-8	2016	Due to these proteins having known cysteine residues susceptible to oxidation, we subsequently investigated and observed transcriptional remodeling of metabolic enzymes, a shift to more oxidized redox couples, and post-translational thiol oxidation of STIM1.	Sulfhydryl Compounds	233-238	stromal interaction molecule 1	Homo sapiens	252-257
27502484-0	2016	TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux.	Sulfhydryl Compounds	44-49	thioredoxin related transmembrane protein 1	Homo sapiens	0-4
27502484-8	2016	As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression.	Sulfhydryl Compounds	5-10	thioredoxin related transmembrane protein 1	Homo sapiens	35-39
27261461-2	2016	Human SOD1 (hSOD1) contains four cysteines, including Cys(57) and Cys(146), which have been linked to protein stability and folding via forming a disulfide bond, and Cys(6) and Cys(111) as free thiols.	Sulfhydryl Compounds	194-200	superoxide dismutase 1	Homo sapiens	6-10
27261461-2	2016	Human SOD1 (hSOD1) contains four cysteines, including Cys(57) and Cys(146), which have been linked to protein stability and folding via forming a disulfide bond, and Cys(6) and Cys(111) as free thiols.	Sulfhydryl Compounds	194-200	superoxide dismutase 1	Homo sapiens	12-17
27134014-3	2016	After hydrolysis, the mixed SAMs exhibit behaviors from antimicrobial to antifouling, since the COOCH3-thiols were translated into carboxylic acid (COO(-)-) terminated thiols, which carried a net charge of -1 e. Simulation results showed that the main differences between COOCH3-/N(CH3)3(+)-SAM and COO(-)-/N(CH3)3(+)-SAM are the charged property and the hydration layer above the surface.	Sulfhydryl Compounds	103-109	methionine adenosyltransferase 1A	Homo sapiens	28-32
27134014-14	2016	The mixed SAMs, constructed from a 1:1 combination of COOCH3- and N(CH3)3(+)-terminated thiols, can induce protein adsorption mainly through the electrostatic interaction.	Sulfhydryl Compounds	88-94	methionine adenosyltransferase 1A	Homo sapiens	10-14
27134014-15	2016	When the COOCH3-terminated thiols were hydrolyzed to negatively charged COO(-)-terminated thiols, the mixed-charged SAMs switched from antimicrobial to antifouling.	Sulfhydryl Compounds	27-33	methionine adenosyltransferase 1A	Homo sapiens	116-120
27134014-15	2016	When the COOCH3-terminated thiols were hydrolyzed to negatively charged COO(-)-terminated thiols, the mixed-charged SAMs switched from antimicrobial to antifouling.	Sulfhydryl Compounds	90-96	methionine adenosyltransferase 1A	Homo sapiens	116-120
27022137-8	2016	The multivariate analysis identified a significant association between the variables PON1-Q192R (Wilks" lambda = 0.85, P = 0.002) and PON-aryl (Wilks" lambda = 0.896, P = 0.017), with FRAP and total thiol.	Sulfhydryl Compounds	199-204	paraoxonase 1	Homo sapiens	85-89
27022137-8	2016	The multivariate analysis identified a significant association between the variables PON1-Q192R (Wilks" lambda = 0.85, P = 0.002) and PON-aryl (Wilks" lambda = 0.896, P = 0.017), with FRAP and total thiol.	Sulfhydryl Compounds	199-204	paraoxonase 1	Homo sapiens	85-88
27284000-0	2016	Exploring the arachidonic acid-induced structural changes in phagocyte NADPH oxidase p47(phox) and p67(phox) via thiol accessibility and SRCD spectroscopy.	Sulfhydryl Compounds	113-118	pleckstrin	Homo sapiens	85-88
27284000-0	2016	Exploring the arachidonic acid-induced structural changes in phagocyte NADPH oxidase p47(phox) and p67(phox) via thiol accessibility and SRCD spectroscopy.	Sulfhydryl Compounds	113-118	pleckstrin	Homo sapiens	89-93
27284000-0	2016	Exploring the arachidonic acid-induced structural changes in phagocyte NADPH oxidase p47(phox) and p67(phox) via thiol accessibility and SRCD spectroscopy.	Sulfhydryl Compounds	113-118	CD33 molecule	Homo sapiens	99-102
27284000-10	2016	While five of the nine thiol groups in p67(phox) and all of them in p47(phox) have low access to the solvent when proteins are alone in solution, all of them become fully accessible when proteins are together.	Sulfhydryl Compounds	23-28	CD33 molecule	Homo sapiens	39-42
27284000-10	2016	While five of the nine thiol groups in p67(phox) and all of them in p47(phox) have low access to the solvent when proteins are alone in solution, all of them become fully accessible when proteins are together.	Sulfhydryl Compounds	23-28	pleckstrin	Homo sapiens	43-47
27284000-10	2016	While five of the nine thiol groups in p67(phox) and all of them in p47(phox) have low access to the solvent when proteins are alone in solution, all of them become fully accessible when proteins are together.	Sulfhydryl Compounds	23-28	pleckstrin	Homo sapiens	68-71
27377780-1	2016	Mammalian thioredoxin 1 (Trx1) and the selenoprotein Trx reductase 1 (TrxR1) are key cellular enzymes that function coordinately in thiol-based redox regulation and signaling.	Sulfhydryl Compounds	132-137	thioredoxin	Homo sapiens	10-23
27212016-4	2016	Proteins with free thiols were rapidly modified by 4MBQ with apparent second order rate constants, k2 of (3.1+-0.2)x10(4)M(-1)s(-1) for bovine serum albumin (BSA) and (4.8+-0.2)x10(3)M(-1)s(-1) for human serum albumin at pH 7.0.	Sulfhydryl Compounds	19-25	albumin	Homo sapiens	143-156
27212016-4	2016	Proteins with free thiols were rapidly modified by 4MBQ with apparent second order rate constants, k2 of (3.1+-0.2)x10(4)M(-1)s(-1) for bovine serum albumin (BSA) and (4.8+-0.2)x10(3)M(-1)s(-1) for human serum albumin at pH 7.0.	Sulfhydryl Compounds	19-25	albumin	Homo sapiens	204-217
27212016-5	2016	These values are at least 12-fold greater than that for alpha-lactalbumin (4.0+-0.2)x10(2)M(-1)s(-1), which does not contain any free thiols.	Sulfhydryl Compounds	134-140	lactalbumin alpha	Homo sapiens	56-73
27377780-1	2016	Mammalian thioredoxin 1 (Trx1) and the selenoprotein Trx reductase 1 (TrxR1) are key cellular enzymes that function coordinately in thiol-based redox regulation and signaling.	Sulfhydryl Compounds	132-137	thioredoxin	Homo sapiens	25-29
27377780-1	2016	Mammalian thioredoxin 1 (Trx1) and the selenoprotein Trx reductase 1 (TrxR1) are key cellular enzymes that function coordinately in thiol-based redox regulation and signaling.	Sulfhydryl Compounds	132-137	thioredoxin	Homo sapiens	25-28
27377780-1	2016	Mammalian thioredoxin 1 (Trx1) and the selenoprotein Trx reductase 1 (TrxR1) are key cellular enzymes that function coordinately in thiol-based redox regulation and signaling.	Sulfhydryl Compounds	132-137	thioredoxin reductase 1	Homo sapiens	70-75
27122109-0	2016	A CE-LIF method based on long wavelength fluorescence labeling for the analysis of thiols in human urine.	Sulfhydryl Compounds	83-89	LIF interleukin 6 family cytokine	Homo sapiens	5-8
27183920-9	2016	Moreover, it was shown in vitro that GSTs can strongly increase the efficiency of GSH to protect against the alkylation of the model thiol N-acetylcysteine by reactive diclofenac metabolites.	Sulfhydryl Compounds	133-138	glutathione S-transferase kappa 1	Homo sapiens	37-41
27174129-2	2016	Ado-trastuzumab emtansine utilizes the Ab-SMCC-DM1 format, in which the thiol-functionalized maytansinoid cytotoxic agent, DM1, is linked to the antibody (Ab) via the maleimide moiety of the heterobifunctional SMCC linker.	Sulfhydryl Compounds	72-77	immunoglobulin heavy diversity 1-7	Homo sapiens	47-50
27174129-2	2016	Ado-trastuzumab emtansine utilizes the Ab-SMCC-DM1 format, in which the thiol-functionalized maytansinoid cytotoxic agent, DM1, is linked to the antibody (Ab) via the maleimide moiety of the heterobifunctional SMCC linker.	Sulfhydryl Compounds	72-77	immunoglobulin heavy diversity 1-7	Homo sapiens	123-126
27174129-11	2016	Experiments on ex vivo stability confirm that some loss of maytansinoid from Ab-SMCC-DM1 conjugates can occur via thiol elimination, but at a slower rate than the corresponding rate of loss reported for thiol-maleimide links formed at thiols derived by reduction of endogenous cysteine residues in antibodies, consistent with expected differences in thiol-maleimide stability related to thiol pKa.	Sulfhydryl Compounds	114-119	immunoglobulin heavy diversity 1-7	Homo sapiens	85-88
27420328-4	2016	Evaluation of the free thiol content after reduction by reducing reagent showed that metal-ion binding elicited strong retardation of cysteine oxidation in the order of Zn(II)&gt;Ni(II)&gt;Co(II).	Sulfhydryl Compounds	23-28	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	189-195
27015647-4	2016	Subsequently, the NPs were conjugated with thiol modified MUC-1 aptamers.	Sulfhydryl Compounds	43-48	mucin 1, cell surface associated	Homo sapiens	58-63
26774751-12	2016	This study demonstrates for the first time that mitochondrial thiol modification inhibits metabolism via inhibition of both aconitase and GAC in a breast cancer cell model.	Sulfhydryl Compounds	62-67	glutaminase	Homo sapiens	138-141
27191177-0	2016	Thiol-Activated HNO Release from a Ruthenium Antiangiogenesis Complex and HIF-1alpha Inhibition for Cancer Therapy.	Sulfhydryl Compounds	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
27191177-8	2016	Together, these results demonstrate for the first time thiol-dependent production of HNO by a ruthenium complex and subsequent destabilization of HIF-1alpha.	Sulfhydryl Compounds	55-60	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
27283928-1	2016	A reactivity and selectivity study of O,O-diethyl 2,4-dinitrophenyl phosphate () and O,O-diethyl 2,4-dinitrophenyl thionophosphate () with a series of thiols of low molecular weight: N-acetyl cysteine (NAC), l-cysteine (Cys), homocysteine (Hcys), glutathione (GSH), and d-penicillamine (Pen) was conducted.	Sulfhydryl Compounds	151-157	tetraspanin 33	Homo sapiens	287-290
27216999-6	2016	The aryl nicotinate of compound 5k, as indicated by molecular docking was found to engage His121 and critical enzyme thiols, i.e., Cys163 of caspase-3 for its potent activity.	Sulfhydryl Compounds	117-123	caspase 3	Rattus norvegicus	141-150
27009048-5	2016	Furthermore, the dimerization of sGC and PKG and vasodilation induced by SO2 in precontracted rings were significantly prevented by thiol reductants dithiothreitol (DTT).	Sulfhydryl Compounds	132-137	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	33-36
29423025-9	2018	Pretreatment of cells with dithiothreitol abrogated the MSeA-induced NQO-1 expression, suggesting that MSeA causes Keap1 thiol modification.	Sulfhydryl Compounds	121-126	NAD(P)H quinone dehydrogenase 1	Homo sapiens	69-74
29423025-9	2018	Pretreatment of cells with dithiothreitol abrogated the MSeA-induced NQO-1 expression, suggesting that MSeA causes Keap1 thiol modification.	Sulfhydryl Compounds	121-126	kelch like ECH associated protein 1	Homo sapiens	115-120
26901459-3	2016	The biosensor was assembled in two stages: (1) the immobilization of the anti-miRNA-155 that was thiol modified on an Au-screen printed electrode (Au-SPE), followed by (2) blocking the areas of non-specific binding with mercaptosuccinic acid.	Sulfhydryl Compounds	97-102	microRNA 155	Homo sapiens	78-87
27229448-3	2016	It was reported that thiols react in vitro with DON at two positions: reversibly at C-10 of the alpha,beta-unsaturated ketone and irreversibly at C-13 of the epoxy group.	Sulfhydryl Compounds	21-27	homeobox C10	Homo sapiens	84-88
27229448-3	2016	It was reported that thiols react in vitro with DON at two positions: reversibly at C-10 of the alpha,beta-unsaturated ketone and irreversibly at C-13 of the epoxy group.	Sulfhydryl Compounds	21-27	homeobox C13	Homo sapiens	146-150
27009048-0	2016	The vasodilatory effect of sulfur dioxide via SGC/cGMP/PKG pathway in association with sulfhydryl-dependent dimerization.	Sulfhydryl Compounds	87-97	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	46-49
27271225-3	2016	Functionalization of GO with a peptide substrate for MMP-2 bearing a thiol group leads to its self-assembly via disulfide bonding, accompanied by self-quenching of GO"s strong fluorescence.	Sulfhydryl Compounds	69-74	matrix metallopeptidase 2	Homo sapiens	53-58
27002306-6	2016	Y-632 inhibited Hsp90 function mainly through inducing intracellular thiol oxidation, which led to disruption of the Hsp90-Hsp70/Hsp90 organizing protein complex and further induced cell adhesion inhibition, G0 /G1 cell cycle arrest, and apoptosis.	Sulfhydryl Compounds	69-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	16-21
26946085-2	2016	Previous redox-proteomics studies have suggested that mitochondrial malate dehydrogenase (mMDH), a key enzyme in the tricarboxylic acid (TCA) cycle and redox shuttling, is under thiol-based redox regulation as a target candidate of thioredoxin (Trx).	Sulfhydryl Compounds	178-183	malate dehydrogenase 2, NAD (mitochondrial)	Mus musculus	90-94
26946085-2	2016	Previous redox-proteomics studies have suggested that mitochondrial malate dehydrogenase (mMDH), a key enzyme in the tricarboxylic acid (TCA) cycle and redox shuttling, is under thiol-based redox regulation as a target candidate of thioredoxin (Trx).	Sulfhydryl Compounds	178-183	thioredoxin H-type 1	Arabidopsis thaliana	232-243
26946085-2	2016	Previous redox-proteomics studies have suggested that mitochondrial malate dehydrogenase (mMDH), a key enzyme in the tricarboxylic acid (TCA) cycle and redox shuttling, is under thiol-based redox regulation as a target candidate of thioredoxin (Trx).	Sulfhydryl Compounds	178-183	thioredoxin H-type 1	Arabidopsis thaliana	245-248
27002306-6	2016	Y-632 inhibited Hsp90 function mainly through inducing intracellular thiol oxidation, which led to disruption of the Hsp90-Hsp70/Hsp90 organizing protein complex and further induced cell adhesion inhibition, G0 /G1 cell cycle arrest, and apoptosis.	Sulfhydryl Compounds	69-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	117-122
27002306-6	2016	Y-632 inhibited Hsp90 function mainly through inducing intracellular thiol oxidation, which led to disruption of the Hsp90-Hsp70/Hsp90 organizing protein complex and further induced cell adhesion inhibition, G0 /G1 cell cycle arrest, and apoptosis.	Sulfhydryl Compounds	69-74	heat shock protein 90 alpha family class A member 1	Homo sapiens	117-122
26923386-2	2016	Glutathione reductase is responsible for maintaining the supply of reduced glutathione; one of the most abundant reducing thiols in the majority of cells.	Sulfhydryl Compounds	122-128	glutathione-disulfide reductase	Homo sapiens	0-21
26928883-8	2016	Serum total thiol, native thiol, and disulfide levels decreased significantly in the CSX group compared with the control group (P&lt;0.001).	Sulfhydryl Compounds	12-17	NK2 homeobox 5	Homo sapiens	85-88
26928883-8	2016	Serum total thiol, native thiol, and disulfide levels decreased significantly in the CSX group compared with the control group (P&lt;0.001).	Sulfhydryl Compounds	26-31	NK2 homeobox 5	Homo sapiens	85-88
26928883-10	2016	Although disulfide/native thiol levels increased in the CSX group, this reduction did not reach statistical significance (5.8 vs. 5.5, P&gt;0.05).	Sulfhydryl Compounds	26-31	NK2 homeobox 5	Homo sapiens	56-59
26928883-11	2016	The reduction of thiols was correlated negatively with CRP and NLR (P&lt;0.001).	Sulfhydryl Compounds	17-23	C-reactive protein	Homo sapiens	55-58
26928883-13	2016	Also, receiver operating characteristic curve analysis showed that serum total thiol values of 338.4 or below could predict the CSX with 86% sensitivity and 84% specificity (area under curve=0.903; 95% confidence interval: 0.842-0.965).	Sulfhydryl Compounds	79-84	NK2 homeobox 5	Homo sapiens	128-131
26928883-14	2016	CONCLUSION: Serum total thiol levels decreased significantly in CSX and this reduction independently predicted CSX with strong sensitivity and specificity.	Sulfhydryl Compounds	24-29	NK2 homeobox 5	Homo sapiens	64-67
26928883-14	2016	CONCLUSION: Serum total thiol levels decreased significantly in CSX and this reduction independently predicted CSX with strong sensitivity and specificity.	Sulfhydryl Compounds	24-29	NK2 homeobox 5	Homo sapiens	111-114
26928883-15	2016	This suggests that the reduction in thiols along with increased inflammation may play a pathophysiological role in the development of CSX.	Sulfhydryl Compounds	36-42	NK2 homeobox 5	Homo sapiens	134-137
26928883-4	2016	The aim of this study was to investigate thiol levels and thiol/disulfide homeostasis in CSX patients.	Sulfhydryl Compounds	41-46	NK2 homeobox 5	Homo sapiens	89-92
26928883-4	2016	The aim of this study was to investigate thiol levels and thiol/disulfide homeostasis in CSX patients.	Sulfhydryl Compounds	58-63	NK2 homeobox 5	Homo sapiens	89-92
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Sulfhydryl Compounds	245-250	aldehyde dehydrogenase 3 family member A2	Homo sapiens	39-67
26837749-3	2016	We hypothesised that HOSCN, a thiol-specific oxidant may target the iron-sulphur cluster of aconitase (both isolated, and within primary human coronary artery endothelial cells; HCAEC) resulting in enzyme dysfunction, release of iron, and conversion of the cytosolic isoform to iron response protein-1, which regulates intracellular iron levels.	Sulfhydryl Compounds	30-35	aconitase 1	Homo sapiens	278-301
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Sulfhydryl Compounds	245-250	aldehyde dehydrogenase 3 family member A2	Homo sapiens	69-74
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Sulfhydryl Compounds	245-250	aldo-keto reductase family 1 member B	Homo sapiens	77-93
27081212-1	2016	Thioredoxin (Trx) is a ubiquitous oxidoreductase maintaining protein-bound cysteine residues in the reduced thiol state.	Sulfhydryl Compounds	108-113	oxidoreductase	Escherichia coli	34-48
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Sulfhydryl Compounds	245-250	aldo-keto reductase family 1 member B	Homo sapiens	95-97
26887678-0	2016	Thiol-Disulfide Exchange in Human Growth Hormone.	Sulfhydryl Compounds	0-5	growth hormone 1	Homo sapiens	34-48
26887678-1	2016	PURPOSE: Thiol-disulfide exchange was monitored in recombinant human growth hormone (hGH) and in model tryptic peptides derived from hGH to investigate the effects of higher-order structure on the reaction.	Sulfhydryl Compounds	9-14	growth hormone 1	Homo sapiens	69-83
27162359-5	2016	A biotin switch assay shows that GSSG-ester-induced HIF-1alpha contains reversibly modified thiols, and MS confirms GSH adducts on Cys(520) (mouse Cys(533)).	Sulfhydryl Compounds	92-98	hypoxia inducible factor 1, alpha subunit	Mus musculus	52-62
26775941-5	2016	These kinetic data suggest that small molar excesses of some plant extracts relative to the MPI thiol concentration should afford significant protection against MbFe(IV)O-mediated oxidation.	Sulfhydryl Compounds	96-101	mannose phosphate isomerase	Homo sapiens	92-95
27331089-1	2016	We have recently reported SAR data describing the pharmacological activity of a series of phenyl alkyl selenides and tellurides which catalyse the oxidation of thiols by hydrogen peroxide (H2O2), "The design of redox active thiol peroxidase mimics: dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action" B. Zadehvakili, S.M.	Sulfhydryl Compounds	160-166	sarcosine dehydrogenase	Homo sapiens	26-29
27137918-3	2016	After expression in Xenopus oocytes, human SGLT1 molecules (hSGLT1) were labelled on an externally accessible cysteine residue with a thiol-reactive fluorophore (tetramethylrhodamine-C5-maleimide, TMR).	Sulfhydryl Compounds	134-139	solute carrier family 5 member 1	Homo sapiens	43-48
27054760-0	2016	Unexpected Thiols Triggering Photoluminescent Enhancement of Cytidine Stabilized Au Nanoclusters for Sensitive Assays of Glutathione Reductase and Its Inhibitors Screening.	Sulfhydryl Compounds	11-17	glutathione-disulfide reductase	Homo sapiens	121-142
27054760-2	2016	However, we here report an unexpected PL enhancement of cytidine stabilized Au (AuCyt) NCs triggered by thiols, such as reduced glutathione (GSH) at sub-muM level, while such phenomena have not been observed for Au NCs capped with similar adenosine/cytidine nucleotides.	Sulfhydryl Compounds	104-110	latexin	Homo sapiens	153-156
27058612-2	2016	A mild thiol-ene click reaction was used to anchor 1-allylimidazolium-per(p-methyl)phenylcarbamoylated-beta-CD and 1-allylimidazolium-per(p-chloride)phenylcarbamoylated-beta-CD onto thiol-modified porous silica giving structurally well-defined stable cationic multifunctional CD chiral stationary phases (CSP1 and CSP2 respectively).	Sulfhydryl Compounds	7-12	regulator of calcineurin 1	Homo sapiens	305-309
27058612-2	2016	A mild thiol-ene click reaction was used to anchor 1-allylimidazolium-per(p-methyl)phenylcarbamoylated-beta-CD and 1-allylimidazolium-per(p-chloride)phenylcarbamoylated-beta-CD onto thiol-modified porous silica giving structurally well-defined stable cationic multifunctional CD chiral stationary phases (CSP1 and CSP2 respectively).	Sulfhydryl Compounds	7-12	regulator of calcineurin 2	Homo sapiens	314-318
26775941-2	2016	Blocking of the protein thiol groups on the MPI by N-ethylmaleimide (NEM) markedly reduced this rate constant to kMPI-NEM=1.3 +- 0.4 x 10(3)M(-1)s(-1) consistent with a key role for the Cys residues on MPI as targets for haem protein-mediated oxidation.	Sulfhydryl Compounds	24-29	mannose phosphate isomerase	Homo sapiens	44-47
26775941-2	2016	Blocking of the protein thiol groups on the MPI by N-ethylmaleimide (NEM) markedly reduced this rate constant to kMPI-NEM=1.3 +- 0.4 x 10(3)M(-1)s(-1) consistent with a key role for the Cys residues on MPI as targets for haem protein-mediated oxidation.	Sulfhydryl Compounds	24-29	mannose phosphate isomerase	Homo sapiens	114-117
27027927-7	2016	To probe biological utility, thiol group uncaging was carried out using a peptide derived from the protein K-Ras4B to yield a sequence that is a known substrate for protein farnesyltransferase; irradiation of the NDBF-caged peptide in the presence of the enzyme resulted in the formation of the farnesylated product.	Sulfhydryl Compounds	29-34	KRAS proto-oncogene, GTPase	Homo sapiens	107-114
27007881-6	2016	Azide-functionalized micelles and thiol-containing Fab were linked using a heterobifunctional cross-linker (FPM-PEG4-DBCO) that contained a fluorophenyl-maleimide for stable conjugation to Fabs thiols and a strained alkyne (DBCO) group for coupling to micelle azide groups.	Sulfhydryl Compounds	34-39	FA complementation group B	Homo sapiens	51-54
27137918-3	2016	After expression in Xenopus oocytes, human SGLT1 molecules (hSGLT1) were labelled on an externally accessible cysteine residue with a thiol-reactive fluorophore (tetramethylrhodamine-C5-maleimide, TMR).	Sulfhydryl Compounds	134-139	solute carrier family 5 member 1	Homo sapiens	60-66
26709731-6	2016	The well-structured N-terminus, compact barrel form, differences in the loop regions, specific transmembrane segments and the abundance of thiols in VDAC-2 enable this isoform to perform a different subset of regulatory functions, establish anti-apoptotic features and contribute to gametogenesis.	Sulfhydryl Compounds	139-145	voltage dependent anion channel 2	Homo sapiens	149-155
27562997-1	2016	Earlier it has been shown that extracellular glutathione peroxidase (GPx3) from human plasma is able to use cysteine (Cys-SH) instead of glutathione (GSH) as a thiol substrate.	Sulfhydryl Compounds	160-165	glutathione peroxidase 3	Homo sapiens	31-67
27562997-1	2016	Earlier it has been shown that extracellular glutathione peroxidase (GPx3) from human plasma is able to use cysteine (Cys-SH) instead of glutathione (GSH) as a thiol substrate.	Sulfhydryl Compounds	160-165	glutathione peroxidase 3	Homo sapiens	69-73
27562997-8	2016	The most probable outcome of this result is the ability of rat GPx3 to utilize all three thiols as substrates for oxidation.	Sulfhydryl Compounds	89-95	glutathione peroxidase 3	Rattus norvegicus	63-67
26898502-5	2016	We report that multiple thiol-containing proteins involved in metabolism and glycolysis; fructose bisphosphate aldolase, triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and creatine kinase, together with a number of chaperone, antioxidant and structural proteins, were modified in a reversible manner in macrophages treated with HOSCN.	Sulfhydryl Compounds	24-29	triosephosphate isomerase 1	Homo sapiens	121-146
26898502-5	2016	We report that multiple thiol-containing proteins involved in metabolism and glycolysis; fructose bisphosphate aldolase, triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and creatine kinase, together with a number of chaperone, antioxidant and structural proteins, were modified in a reversible manner in macrophages treated with HOSCN.	Sulfhydryl Compounds	24-29	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	148-188
26898502-5	2016	We report that multiple thiol-containing proteins involved in metabolism and glycolysis; fructose bisphosphate aldolase, triosephosphate isomerase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and creatine kinase, together with a number of chaperone, antioxidant and structural proteins, were modified in a reversible manner in macrophages treated with HOSCN.	Sulfhydryl Compounds	24-29	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	190-195
32263341-2	2016	In this study, we obtained disulfide-crosslinked albumin hydrogels using the protein"s own thiol groups.	Sulfhydryl Compounds	91-96	albumin	Homo sapiens	49-56
27114613-1	2016	The structural composition of CFTR"s anion permeation pathway has been proposed to consist of a short narrow region, flanked by two wide inner and outer vestibules, based on systematic cysteine scanning studies using thiol-reactive probes of various sizes.	Sulfhydryl Compounds	217-222	CF transmembrane conductance regulator	Homo sapiens	30-34
27826418-6	2016	Our findings are interpreted to mean that thiols of FL-hHO-2s are not involved in HO-2 activation or inhibition by the compounds that have been designed and identified by us.	Sulfhydryl Compounds	42-48	heme oxygenase 2	Homo sapiens	56-60
26945724-7	2016	To elucidate these findings, it was found that PEITC-induced HO-1 upregulation can be inhibited with thiol antioxidants (glutathione and N-acetylcysteine).	Sulfhydryl Compounds	101-106	heme oxygenase 1	Homo sapiens	61-65
26974228-2	2016	Our objective was to compare the stability of AuNP conjugated to MCP via a single thiol [DOTA-PEG-ortho-pyridyl disulfide (OPSS)], a dithiol [DOTA-PEG-lipoic acid (LA)] or multithiol end-group [PEG-pGlu(DOTA)8-LA4] and determine the elimination and biodistribution of these (177)Lu-labeled MCP-AuNP in mice.	Sulfhydryl Compounds	82-87	CD46 antigen, complement regulatory protein	Mus musculus	65-68
26492953-7	2016	MAIN OUTCOME MEASURES: The relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS.	Sulfhydryl Compounds	44-49	LAP	Homo sapiens	77-80
25975991-6	2016	The thiol antioxidant barrier (-SHp) level significantly decreased 2 weeks after MeHg exposure, which is an early stage at which no systemic oxidative stress, histopathological changes, or clinical signs were detected.	Sulfhydryl Compounds	4-9	nuclear receptor subfamily 0, group B, member 2	Rattus norvegicus	32-35
26492468-6	2016	In the presence of carbamate pesticide, the activity of AChE is inhibited, and the amount of the product containing the thiol group generated by the hydrolysis reaction of acetylthiocholine chloride (ACh) decreases, resulting in the release of a low concentration of Hg(2+).	Sulfhydryl Compounds	120-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	56-60
26851520-10	2016	Using two different therapeutic antibodies--Trastuzumab (anti-HER2) and Cetuximab (anti-EGFR)--we show labeling with pHAb dye using amine and thiol chemistries and impact of chemistry and dye to antibody ration on internalization.	Sulfhydryl Compounds	142-147	epidermal growth factor receptor	Homo sapiens	88-92
27019961-6	2016	The elimination of buried free thiols in FGF-1 can substantially increase the protein half-life in cell culture.	Sulfhydryl Compounds	31-37	fibroblast growth factor 1	Homo sapiens	41-46
26709469-8	2016	Finally, the use of the mixed-mode thiol-acrylate PEG4A-peptide hydrogels is explored for in situ encapsulation of hepatocellular carcinoma cells (Huh7).	Sulfhydryl Compounds	35-40	MIR7-3 host gene	Homo sapiens	147-151
26823467-8	2016	H2O2 inhibited Panx1 function temporarily by formation of disulfide bonds at the thiol group of its terminal cysteine.	Sulfhydryl Compounds	81-86	pannexin 1	Homo sapiens	15-20
26964514-0	2016	Secreted APE1/Ref-1 inhibits TNF-alpha-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor.	Sulfhydryl Compounds	79-84	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	9-13
26827822-1	2016	Cadmium is an environmental electrophile that modifies protein reactive thiols such as Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Sulfhydryl Compounds	72-78	kelch like ECH associated protein 1	Bos taurus	87-122
26827822-1	2016	Cadmium is an environmental electrophile that modifies protein reactive thiols such as Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Sulfhydryl Compounds	72-78	kelch like ECH associated protein 1	Bos taurus	124-129
26827822-1	2016	Cadmium is an environmental electrophile that modifies protein reactive thiols such as Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Sulfhydryl Compounds	72-78	NFE2 like bZIP transcription factor 2	Bos taurus	156-199
26827822-1	2016	Cadmium is an environmental electrophile that modifies protein reactive thiols such as Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of nuclear factor-erythroid 2-related factor 2 (Nrf2).	Sulfhydryl Compounds	72-78	NFE2 like bZIP transcription factor 2	Bos taurus	201-205
26809007-3	2016	To exploit the potential antitumor activity of MMC and reduce its toxicity we have previously developed a formulation of pegylated liposomes with a lipophilic prodrug of MMC (PL-MLP), activated by endogenous reducing agents which are abundant in the tumor cell environment in the form of different thiols.	Sulfhydryl Compounds	298-304	cysteine and glycine-rich protein 3	Mus musculus	178-181
26964514-0	2016	Secreted APE1/Ref-1 inhibits TNF-alpha-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor.	Sulfhydryl Compounds	79-84	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	14-19
26964514-0	2016	Secreted APE1/Ref-1 inhibits TNF-alpha-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor.	Sulfhydryl Compounds	79-84	tumor necrosis factor	Homo sapiens	29-38
26964514-6	2016	Additionally, recombinant human (rh) APE1/Ref-1 with reducing activity induced a conformational change in rh TNF-alpha receptor 1 (TNFR1) by thiol-disulfide exchange.	Sulfhydryl Compounds	141-146	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	37-41
26964514-6	2016	Additionally, recombinant human (rh) APE1/Ref-1 with reducing activity induced a conformational change in rh TNF-alpha receptor 1 (TNFR1) by thiol-disulfide exchange.	Sulfhydryl Compounds	141-146	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	42-47
26964514-6	2016	Additionally, recombinant human (rh) APE1/Ref-1 with reducing activity induced a conformational change in rh TNF-alpha receptor 1 (TNFR1) by thiol-disulfide exchange.	Sulfhydryl Compounds	141-146	TNF receptor superfamily member 1A	Homo sapiens	109-129
26964514-6	2016	Additionally, recombinant human (rh) APE1/Ref-1 with reducing activity induced a conformational change in rh TNF-alpha receptor 1 (TNFR1) by thiol-disulfide exchange.	Sulfhydryl Compounds	141-146	TNF receptor superfamily member 1A	Homo sapiens	131-136
26644402-0	2016	An Alternative Thiol-Reactive Dye to Analyze Ligand Interactions with the Chemokine Receptor CXCR2 Using a New Thermal Shift Assay Format.	Sulfhydryl Compounds	15-20	C-X-C motif chemokine receptor 2	Homo sapiens	93-98
26839920-3	2016	The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode.	Sulfhydryl Compounds	29-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-145
26839920-3	2016	The competitive binding by a thiol group (-SH), produced in the hydrolysis reaction of acetylthiocholine (ACh) chloride with acetylcholinesterase (AChE), removes mercury ions from the base pairs, causing a nuclease-catalyzed digestion, and the subsequent electrochemical response increase due to the weak electrostatic repulsion between the product-mononucleotides and the ITO electrode.	Sulfhydryl Compounds	29-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-151
27027965-2	2016	The oxidoreductase glutaredoxin-1 (Glrx1), under physiological conditions, catalyzes deglutathionylation and restores the protein thiol group.	Sulfhydryl Compounds	130-135	glutaredoxin	Mus musculus	35-40
26644402-4	2016	Here, we describe a differential scanning fluorimetry (DSF) screening method using the thiol-reactive BODIPY FL-cystine dye to monitor thermal unfolding of the G-protein-coupled receptor (GPCR), CXCR2.	Sulfhydryl Compounds	87-92	C-X-C motif chemokine receptor 2	Homo sapiens	195-200
26361990-17	2016	In summary, thiol compounds such as GSH or NAC constitute a promising approach to improve the therapy for SM injury.	Sulfhydryl Compounds	12-17	synuclein alpha	Homo sapiens	43-46
26593282-7	2016	We furthermore detected slight differences in thiol status of parasites transiently transfected with hGrx1-roGFP2 in comparison with control 3D7 cells.	Sulfhydryl Compounds	46-51	glutaredoxin	Homo sapiens	101-106
26361990-2	2016	Thiol compounds such as glutathione (GSH) and N-acetylcysteine (NAC) have been suggested as potential antidotes.	Sulfhydryl Compounds	0-5	synuclein alpha	Homo sapiens	46-68
26494253-0	2016	A novel fluorogenic probe for the investigation of free thiols: Application to kinetic measurements of acetylcholinesterase activity.	Sulfhydryl Compounds	56-62	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123
26683377-8	2016	Also, the cell-permeable thiol N-acetyl l-cysteine, reverses DMF inhibition of the NFkappaB pathway, supporting the notion that the electrophile, DMF, acts via covalent modification.	Sulfhydryl Compounds	25-30	nuclear factor kappa B subunit 1	Homo sapiens	83-91
26702055-8	2016	Our results suggest that Cys-258 residues are heterogeneously modified in the hTRPV1 tetrameric complex and comprise Cys-258 with free thiol for oxidation sensing and Cys-258, which is involved in the disulfide bond for assisting subunit dimerization.	Sulfhydryl Compounds	135-140	transient receptor potential cation channel subfamily V member 1	Homo sapiens	78-84
26647758-6	2016	This study found that when the disulfide bonds in PDI are reduced to thiols, the reduced PDI exhibits a smaller hydrodynamic diameter than the oxided PDI.	Sulfhydryl Compounds	69-75	prolyl 4-hydroxylase subunit beta	Homo sapiens	50-53
26872211-3	2016	Peroxiredoxin 5 (Prdx5) is a thiol-dependent peroxidase that reduces oxidative stress by catalyzing intramolecular disulfide bonds.	Sulfhydryl Compounds	29-34	peroxiredoxin 5	Rattus norvegicus	0-15
26872211-3	2016	Peroxiredoxin 5 (Prdx5) is a thiol-dependent peroxidase that reduces oxidative stress by catalyzing intramolecular disulfide bonds.	Sulfhydryl Compounds	29-34	peroxiredoxin 5	Rattus norvegicus	17-22
26786359-8	2016	AuStNPs are advantageous for SPR sensing, as it was demonstrated in the sensitive detection of not only thiols, such as ampicillin, but also iodide with the detection limit of 3.2 pM (0.4 ng L(-1)).	Sulfhydryl Compounds	104-110	sepiapterin reductase	Homo sapiens	29-32
26647758-6	2016	This study found that when the disulfide bonds in PDI are reduced to thiols, the reduced PDI exhibits a smaller hydrodynamic diameter than the oxided PDI.	Sulfhydryl Compounds	69-75	prolyl 4-hydroxylase subunit beta	Homo sapiens	89-92
26647758-6	2016	This study found that when the disulfide bonds in PDI are reduced to thiols, the reduced PDI exhibits a smaller hydrodynamic diameter than the oxided PDI.	Sulfhydryl Compounds	69-75	prolyl 4-hydroxylase subunit beta	Homo sapiens	89-92
26601956-3	2016	Interactions of Prx2 with other thiols are not well characterized.	Sulfhydryl Compounds	32-38	peroxiredoxin 2	Mus musculus	16-20
26795153-4	2016	Thiol-disulfide redox regulation is dependent on the conserved redox proteins, glutathione/glutaredoxin (GRX) and thioredoxin (TRX) systems.	Sulfhydryl Compounds	0-5	glutaredoxin	Homo sapiens	79-103
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	Sulfhydryl Compounds	31-36	mitogen-activated protein kinase 1	Homo sapiens	148-151
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	Sulfhydryl Compounds	31-36	mitogen-activated protein kinase 3	Homo sapiens	152-156
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	Sulfhydryl Compounds	31-36	mitogen-activated protein kinase 8	Homo sapiens	157-160
26426352-4	2016	RESULTS: The area under the plasma concentration-time curve (AUC) of the active thiol metabolite of clopidogrel was highest in the CYP2C19 extensive metabolizers (EM) and lowest in the poor metabolizers (PM).	Sulfhydryl Compounds	80-85	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	131-138
27209753-0	2016	[Optical Analysis of the Interaction of Mercaptan Derivatives of Nanogold Particles with Carcinoembryonic Antigen].	Sulfhydryl Compounds	40-49	CEA cell adhesion molecule 3	Homo sapiens	89-113
27209753-15	2016	Fluorescence sensitization effect was observed when mercaptan derivatives of nanogold interacted with carcinoembryonic antigen (CEA) and no fluorescence sensitization effect was found when nanogold interacted with carcinoembryonic antigen (CEA).	Sulfhydryl Compounds	52-61	CEA cell adhesion molecule 3	Homo sapiens	102-126
27209753-15	2016	Fluorescence sensitization effect was observed when mercaptan derivatives of nanogold interacted with carcinoembryonic antigen (CEA) and no fluorescence sensitization effect was found when nanogold interacted with carcinoembryonic antigen (CEA).	Sulfhydryl Compounds	52-61	CEA cell adhesion molecule 3	Homo sapiens	128-131
27209753-16	2016	The study of CEA hyperchromic mechanism of mercaptan derivatives nanogold and the CEA by the method of infrared spectrum, shows that the randomized OH bonds in the Au-protein interaction, showed more on the outside of the plane of bending vibration after the interaction with the mercaptan derivative nanogold, making the energy transfer from mercaptan derivatives nanogold to protein easy; leading to its fluorescence sensitization effect.	Sulfhydryl Compounds	43-52	CEA cell adhesion molecule 3	Homo sapiens	13-16
27209753-16	2016	The study of CEA hyperchromic mechanism of mercaptan derivatives nanogold and the CEA by the method of infrared spectrum, shows that the randomized OH bonds in the Au-protein interaction, showed more on the outside of the plane of bending vibration after the interaction with the mercaptan derivative nanogold, making the energy transfer from mercaptan derivatives nanogold to protein easy; leading to its fluorescence sensitization effect.	Sulfhydryl Compounds	280-289	CEA cell adhesion molecule 3	Homo sapiens	13-16
27209753-16	2016	The study of CEA hyperchromic mechanism of mercaptan derivatives nanogold and the CEA by the method of infrared spectrum, shows that the randomized OH bonds in the Au-protein interaction, showed more on the outside of the plane of bending vibration after the interaction with the mercaptan derivative nanogold, making the energy transfer from mercaptan derivatives nanogold to protein easy; leading to its fluorescence sensitization effect.	Sulfhydryl Compounds	280-289	CEA cell adhesion molecule 3	Homo sapiens	82-85
27209753-16	2016	The study of CEA hyperchromic mechanism of mercaptan derivatives nanogold and the CEA by the method of infrared spectrum, shows that the randomized OH bonds in the Au-protein interaction, showed more on the outside of the plane of bending vibration after the interaction with the mercaptan derivative nanogold, making the energy transfer from mercaptan derivatives nanogold to protein easy; leading to its fluorescence sensitization effect.	Sulfhydryl Compounds	280-289	CEA cell adhesion molecule 3	Homo sapiens	13-16
27209753-16	2016	The study of CEA hyperchromic mechanism of mercaptan derivatives nanogold and the CEA by the method of infrared spectrum, shows that the randomized OH bonds in the Au-protein interaction, showed more on the outside of the plane of bending vibration after the interaction with the mercaptan derivative nanogold, making the energy transfer from mercaptan derivatives nanogold to protein easy; leading to its fluorescence sensitization effect.	Sulfhydryl Compounds	280-289	CEA cell adhesion molecule 3	Homo sapiens	82-85
26763400-1	2016	As a part of our studies to develop a cell-based in vitro photosensitization assay, we examined whether changes of cell-surface thiols and amines on human monocytic cell line THP-1 could be used to predict photosensitizing potential of chemicals.	Sulfhydryl Compounds	128-134	GLI family zinc finger 2	Homo sapiens	175-180
26629855-2	2016	For example, targeting cysteine residues in the ATP-binding pockets of kinases with thiol-reactive molecules has afforded increased selectivity and potency to drugs like imbrutinib, which inhibits the oncogene BTK, and CO-1686 and AZD9291 that target oncogenic mutant EGFR.	Sulfhydryl Compounds	84-89	Bruton tyrosine kinase	Homo sapiens	210-213
26629855-2	2016	For example, targeting cysteine residues in the ATP-binding pockets of kinases with thiol-reactive molecules has afforded increased selectivity and potency to drugs like imbrutinib, which inhibits the oncogene BTK, and CO-1686 and AZD9291 that target oncogenic mutant EGFR.	Sulfhydryl Compounds	84-89	epidermal growth factor receptor	Homo sapiens	268-272
26795153-4	2016	Thiol-disulfide redox regulation is dependent on the conserved redox proteins, glutathione/glutaredoxin (GRX) and thioredoxin (TRX) systems.	Sulfhydryl Compounds	0-5	glutaredoxin	Homo sapiens	105-108
26795153-4	2016	Thiol-disulfide redox regulation is dependent on the conserved redox proteins, glutathione/glutaredoxin (GRX) and thioredoxin (TRX) systems.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	114-125
26795153-4	2016	Thiol-disulfide redox regulation is dependent on the conserved redox proteins, glutathione/glutaredoxin (GRX) and thioredoxin (TRX) systems.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	127-130
26693734-3	2016	We have developed a novel vitamin B12 derivative suitably tailored for disulfide-based conjugation that can undergo cleavage in the presence of glutathione, the most abundant thiol in mammalian cells.	Sulfhydryl Compounds	175-180	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37
26706171-1	2016	A series of novel thiol-based histone deacetylase (HDAC) inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif was designed, synthesized, and evaluated for their HDAC inhibition activity.	Sulfhydryl Compounds	18-23	histone deacetylase 9	Homo sapiens	200-204
26706171-0	2016	Novel thiol-based histone deacetylase inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif: Design, synthesis and SAR study.	Sulfhydryl Compounds	6-11	histone deacetylase 9	Homo sapiens	18-37
26709300-1	2016	In this work, a new nanomaterial of thiol functional ferrocene derivative (Fc-SH) stabilized Au NPs/carbon dots nanocomposite (Au/C NC) coupling with graphene modified glassy carbon electrode (Fc-S-Au/C NC/graphene/GCE) was fabricated to serve as a quadruplet detection platform for ultrasensitive and simultaneous determination of ascorbic acid (AA), dopamine (DA), uric acid (UA) and acetaminophen (AC).	Sulfhydryl Compounds	36-41	aminomethyltransferase	Homo sapiens	215-218
26633597-0	2016	Revealing Intermolecular Interaction and Surface Restructuring of an Aromatic Thiol Assembling on Au(111) by Tip-Enhanced Raman Spectroscopy.	Sulfhydryl Compounds	78-83	TOR signaling pathway regulator	Homo sapiens	109-112
26706171-1	2016	A series of novel thiol-based histone deacetylase (HDAC) inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif was designed, synthesized, and evaluated for their HDAC inhibition activity.	Sulfhydryl Compounds	18-23	histone deacetylase 9	Homo sapiens	30-49
26706171-1	2016	A series of novel thiol-based histone deacetylase (HDAC) inhibitors bearing 3-phenyl-1H-pyrazole-5-carboxamide scaffold as surface recognition motif was designed, synthesized, and evaluated for their HDAC inhibition activity.	Sulfhydryl Compounds	18-23	histone deacetylase 9	Homo sapiens	51-55
26633597-2	2016	We utilized tip-enhanced Raman spectroscopy (TERS) to address the challenge in probing the subtle change of the intermolecular interaction during the assembly of a pyridine-terminated aromatic thiol on the single crystal Au(111) surface that cannot produce enhanced Raman signal, together with electrochemical methods to study the charge transfer properties of SAM.	Sulfhydryl Compounds	193-198	TOR signaling pathway regulator	Homo sapiens	12-15
26597547-2	2016	Pyridyl disulfide functionalized silica particles are prepared by surface chemical reactions, and thiol-terminated poly(oligo(ethylene glycol) monomethyl ether methacrylate) (POEGMA) and bovine serum albumin (BSA) molecules are grafted to the silica particles by thiol-disulfide exchange reactions.	Sulfhydryl Compounds	98-103	albumin	Homo sapiens	194-207
26728034-15	2016	Indeed, docking analyzes performed with a LmABCB3 structural model using trypanothione, the main thiol in this parasite, as a ligand showed how both, LmABCB3 and yeast ATM1, contain a similar thiol-binding pocket.	Sulfhydryl Compounds	97-102	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	168-172
26728034-15	2016	Indeed, docking analyzes performed with a LmABCB3 structural model using trypanothione, the main thiol in this parasite, as a ligand showed how both, LmABCB3 and yeast ATM1, contain a similar thiol-binding pocket.	Sulfhydryl Compounds	192-197	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	168-172
25827171-4	2016	Exploration is also undertaken to assess whether the free thiol form of beta2GPI versus the oxidized disulfide form have distinct functional properties in the setting of hydrogen peroxide (H(2)O(2))-mediated cell death of an immortalized human retinal pigment epithelium (RPE) cell line.	Sulfhydryl Compounds	58-63	apolipoprotein H	Homo sapiens	72-80
26536848-7	2016	Unlike caspase and proteasome inhibitors, low molecular weight thiols, such as N-acetyl-L-cysteine (NAC), prevented Stattic V-induced sperm immobilization and increase responsiveness to acrosome reaction inducers.	Sulfhydryl Compounds	63-69	X-linked Kx blood group	Homo sapiens	100-103
26536848-8	2016	NAC also efficiently prevented the production of superoxide anion, mitochondrial membrane depolarization, intracellular acidification and the oxidation of protein free thiols caused by Stattic V. These results show that the deleterious effects of Stattic V on sperm functions are caused directly or indirectly by excessive intracellular ROS production without causing sperm apoptosis or necrosis.	Sulfhydryl Compounds	168-174	X-linked Kx blood group	Homo sapiens	0-3
25827171-6	2016	Free thiol beta2GPI is shown to protect the immortalized human RPE cell line against H(2)O(2)-induced cell death, whereas the oxidized form of beta2GPI and free thiol bovine serum albumin were not protective.	Sulfhydryl Compounds	5-10	apolipoprotein H	Homo sapiens	11-19
25827171-7	2016	Free thiol beta2GPI levels were significantly decreased in patients with late AMD compared with early AMD and healthy controls.	Sulfhydryl Compounds	5-10	apolipoprotein H	Homo sapiens	11-19
25827171-8	2016	Our observations lead to the hypothesis that free thiol beta2GPI may protect against oxidative stress injury to RPE cells in the early stages of AMD.	Sulfhydryl Compounds	50-55	apolipoprotein H	Homo sapiens	56-64
27766259-5	2016	The fusion protein was purified by affinity chromatography and 29.4 mg/L of native hEGF can be released by thiol induced N-terminal cleavage without any proteases.	Sulfhydryl Compounds	107-112	epidermal growth factor	Homo sapiens	83-87
26547218-6	2016	In the patient group, a positive correlation was determined between c-reactive protein (r = 325, p = 0.007; r = 316, p = 0.010, respectively), fasting blood glucose (r = 279, p = 0.018; r = 251, p = 0.035, respectively), and glycosylated hemoglobin (r = 341, p = 0.004; r = 332, p = 0.005, respectively) and rates of disulfide/native thiol and disulfide/total thiol.	Sulfhydryl Compounds	334-339	C-reactive protein	Homo sapiens	68-86
26726744-5	2016	A thiol-containing protein at m/z 15155 in the brain cell lysate was identified as the cystatin-12 precursor (CST12) from a rat protein database search and a tryptic fragmentation experiment.	Sulfhydryl Compounds	2-7	cystatin 12	Rattus norvegicus	87-98
26726744-5	2016	A thiol-containing protein at m/z 15155 in the brain cell lysate was identified as the cystatin-12 precursor (CST12) from a rat protein database search and a tryptic fragmentation experiment.	Sulfhydryl Compounds	2-7	cystatin 12	Rattus norvegicus	110-115
26547218-6	2016	In the patient group, a positive correlation was determined between c-reactive protein (r = 325, p = 0.007; r = 316, p = 0.010, respectively), fasting blood glucose (r = 279, p = 0.018; r = 251, p = 0.035, respectively), and glycosylated hemoglobin (r = 341, p = 0.004; r = 332, p = 0.005, respectively) and rates of disulfide/native thiol and disulfide/total thiol.	Sulfhydryl Compounds	360-365	C-reactive protein	Homo sapiens	68-86
27642237-10	2016	There was a negative correlation of CRP with native thiol, total thiol, and native thiol/total thiol ratio while there was a positive correlation of CRP with disulphide/native thiol and disulphide/total thiol in the AA group.	Sulfhydryl Compounds	52-57	C-reactive protein	Homo sapiens	36-39
26538256-4	2016	Spectroscopic analyses revealed the presence of thiol (-SH)/thione, disulfide (-S-S-), and sulfonate groups in ETB.	Sulfhydryl Compounds	48-53	endothelin receptor type B	Homo sapiens	111-114
26873191-2	2016	Chemical profile is characterized by reactions with thiols and thiol proteins such as aldehyde dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase, caspases among others.	Sulfhydryl Compounds	52-58	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	110-150
26873191-2	2016	Chemical profile is characterized by reactions with thiols and thiol proteins such as aldehyde dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase, caspases among others.	Sulfhydryl Compounds	52-57	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	110-150
26202203-6	2016	This review briefly describes the newer aspects of MGMT posttranslational regulation by ubiquitination, sumoylation and glutathionylation and reveals how the reactivity of the active site Cys145 can be exploited for potent inhibition and depletion of MGMT by thiol-reacting drugs such as the disulfiram and various dithiocarbamate derivatives.	Sulfhydryl Compounds	259-264	O-6-methylguanine-DNA methyltransferase	Homo sapiens	51-55
26581637-0	2016	Free thiol groups in von Willebrand factor (VWF) are required for its full function under physiological flow conditions.	Sulfhydryl Compounds	5-10	von Willebrand factor	Homo sapiens	44-47
26671656-2	2016	Whether this process can be modulated by a small molecular weight thiol antioxidant N-acetyl-L-cysteine (NAC) was tested in normal human skin fibroblasts (NHFs) using a uni-directional wound healing assay.	Sulfhydryl Compounds	66-71	X-linked Kx blood group	Homo sapiens	105-108
26518762-2	2016	The nucleophilic thiol group allows cysteine to undergo a broad range of redox modifications beyond classical thiol-disulfide redox equilibria, including S-sulfenylation (-SOH), S-sulfinylation (-SO(2)H), S-sulfonylation (-SO(3)H), S-nitrosylation (-SNO), S-sulfhydration (-SSH), S-glutathionylation (-SSG), and others.	Sulfhydryl Compounds	17-22	strawberry notch homolog 1	Homo sapiens	250-253
26581637-1	2016	INTRODUCTION: von Willebrand factor (VWF) is rich in cysteine; next to important structural disulfide bonds, free thiol groups are present.	Sulfhydryl Compounds	114-119	von Willebrand factor	Homo sapiens	37-40
26581637-2	2016	Free thiols on the surface of plasmatic VWF have been shown to play a role in VWF self-association and in platelet binding under pathologically high levels of shear stress.	Sulfhydryl Compounds	5-11	von Willebrand factor	Homo sapiens	40-43
26581637-2	2016	Free thiols on the surface of plasmatic VWF have been shown to play a role in VWF self-association and in platelet binding under pathologically high levels of shear stress.	Sulfhydryl Compounds	5-11	von Willebrand factor	Homo sapiens	78-81
26581637-3	2016	The present study explores the role of VWF free thiol groups under physiological levels of shear stress and in interactions with collagen and platelet-GPIbalpha receptor.	Sulfhydryl Compounds	48-53	von Willebrand factor	Homo sapiens	39-42
26581637-6	2016	RESULTS: Blockade of free thiol groups significantly reduced VWF-mediated platelet recruitment to collagen under physiological flow conditions.	Sulfhydryl Compounds	26-31	von Willebrand factor	Homo sapiens	61-64
26581637-10	2016	CONCLUSIONS: This study shows a significant contribution of free thiol groups in VWF to the mediation of platelet adhesion under physiological shear stress conditions.	Sulfhydryl Compounds	65-70	von Willebrand factor	Homo sapiens	81-84
26581637-11	2016	The free thiol groups are shown to be involved in VWF binding to both collagen III and platelet GP1b receptor.	Sulfhydryl Compounds	9-14	von Willebrand factor	Homo sapiens	50-53
25868756-3	2015	Similar to most Au(I) complexes, Au(III) complexes can inhibit the activities of thiol-containing enzymes, including thioredoxin reductase, via ligand exchange reactions to form Au-S(Se) bonds.	Sulfhydryl Compounds	81-86	peroxiredoxin 5	Homo sapiens	117-138
26398879-0	2015	Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors.	Sulfhydryl Compounds	84-89	insulin degrading enzyme	Homo sapiens	37-61
26398879-2	2015	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that hydrolyzes diverse peptide substrates in both the cytosol and the extracellular space, but current genetic and pharmacological approaches are incapable of selectively inhibiting the protease in specific subcellular compartments.	Sulfhydryl Compounds	36-41	insulin degrading enzyme	Homo sapiens	0-24
26458166-9	2015	The dependence of lysis activity on thiol-disulfide interaction may be related to intrinsic disulfide exchange susceptibility in gp120 that has been reported previously to play a role in HIV-1 cell infection.	Sulfhydryl Compounds	36-41	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	129-134
26398879-2	2015	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that hydrolyzes diverse peptide substrates in both the cytosol and the extracellular space, but current genetic and pharmacological approaches are incapable of selectively inhibiting the protease in specific subcellular compartments.	Sulfhydryl Compounds	36-41	insulin degrading enzyme	Homo sapiens	26-29
26398879-2	2015	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that hydrolyzes diverse peptide substrates in both the cytosol and the extracellular space, but current genetic and pharmacological approaches are incapable of selectively inhibiting the protease in specific subcellular compartments.	Sulfhydryl Compounds	36-41	membrane metalloendopeptidase like 1	Homo sapiens	52-73
26545040-6	2015	On the basis of experimental and theoretic studies, we have clarified the distinct pH effects on the sensing reactivity between QMAs and QMEs and demonstrated that two QMAs (NEt2, OH) are highly sensitive and selective fluorescent probes for thiols in acidic solutions (pH &lt; 7) and promising dyes that can label lysosomes in live cells.	Sulfhydryl Compounds	242-248	tetraspanin 12	Homo sapiens	174-178
26579883-5	2015	The interfacial properties of SAMs can be menu-selected by choice of adsorbate structure using omega-terminated thiols on gold surfaces as a convenient system for studying and utilizing these properties.	Sulfhydryl Compounds	112-118	methionine adenosyltransferase 1A	Homo sapiens	30-34
26579883-11	2015	Our analysis of the SAMs formed from these carefully crafted adsorbates encompassing several series of fluorocarbon-containing thiols provides support for a conclusion that oriented surface dipoles exert a significant influence on interfacial energetics and wettability.	Sulfhydryl Compounds	127-133	methionine adenosyltransferase 1A	Homo sapiens	20-24
26642319-8	2015	Catalase overexpression globally decreased thiol occupancy by &gt;=1.3 fold in 82 proteins, including numerous mitochondrial and contractile proteins.	Sulfhydryl Compounds	43-48	catalase	Mus musculus	0-8
26642319-9	2015	Systems biology analysis assigned the majority of proteins with differentially modified thiols in Cat Tg mice to pathways of aging and cardiac disease, including cellular stress response, proteostasis, and apoptosis.	Sulfhydryl Compounds	88-94	catalase	Mus musculus	98-101
26388496-2	2015	Recent biochemical and cellular studies have revealed a complex thiol-dependent crosstalk between NO and Trx that modulates multiple redox-dependent pathways.	Sulfhydryl Compounds	64-69	thioredoxin	Homo sapiens	105-108
26399480-5	2015	Kinetic data indicate that Cox17 has reactivity similar to glutathione (GSH), the most abundant thiol-rich molecule in the cytoplasm.	Sulfhydryl Compounds	96-101	cytochrome c oxidase copper chaperone COX17	Homo sapiens	27-32
26426521-1	2015	The first water soluble maleimide bearing NIR BF2-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in water with peptides such as glutathione, the cell penetrating peptide (CPP) C(beta-A)SKKKKTKV-NH2 and a thiol substituted cRGD.	Sulfhydryl Compounds	138-143	forkhead box G1	Homo sapiens	46-49
26426521-1	2015	The first water soluble maleimide bearing NIR BF2-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in water with peptides such as glutathione, the cell penetrating peptide (CPP) C(beta-A)SKKKKTKV-NH2 and a thiol substituted cRGD.	Sulfhydryl Compounds	264-269	forkhead box G1	Homo sapiens	46-49
26433365-8	2015	Not only Se-Se@PDAM/HD but also S-S@PDAM/HD coatings showed the ability to continuously catalyze RSNO to generate NO in the presence of proper thiol reducing agent.	Sulfhydryl Compounds	143-148	TP73 antisense RNA 1	Homo sapiens	36-40
26388496-4	2015	MAJOR CONCLUSIONS: The importance and ubiquity of NO-mediated S-nitrosylation of protein thiols as a signaling mechanism is increasingly recognized as is the central role of Trx in regulating S-nitrosylation processes.	Sulfhydryl Compounds	89-95	thioredoxin	Homo sapiens	174-177
26546694-9	2015	An exception was the prevention of thiol group oxidation by PN and SIN-1 where hydrophobic nitroxides were the most effective, apparently due to binding to the protein.	Sulfhydryl Compounds	35-40	MAPK associated protein 1	Homo sapiens	67-72
26515639-2	2015	However, we recently found that the metabolic coupling of two LMW thiols - mycothiol (MSH) and ergothioneine (EGT) - programs the biosynthesis of the anti-infective agent lincomycin A.	Sulfhydryl Compounds	66-72	msh homeobox 2	Homo sapiens	86-89
26536905-9	2015	Interestingly, very high and positive correlations were observed among thiol levels with sperm functionality postthaw: total motility (r = 0.931, P &lt; 0.001), progressive motility (r = 0.904, P &lt; 0.001), and percentage of live spermatozoa without active caspase 3 (r = 0.996, P &lt; 0.001).	Sulfhydryl Compounds	71-76	caspase 3	Homo sapiens	259-268
26536905-10	2015	In contrast, negative correlations were detected between active caspase 3 and thiol content both in living (r = -0.896) and dead (r = -0.940) spermatozoa; additionally, 4-hydroxynonenal levels were negatively correlated with thiol levels (r = -0.856).	Sulfhydryl Compounds	78-83	caspase 3	Homo sapiens	64-73
26536905-10	2015	In contrast, negative correlations were detected between active caspase 3 and thiol content both in living (r = -0.896) and dead (r = -0.940) spermatozoa; additionally, 4-hydroxynonenal levels were negatively correlated with thiol levels (r = -0.856).	Sulfhydryl Compounds	225-230	caspase 3	Homo sapiens	64-73
26041244-5	2015	It was shown that the conformational changes of beta-LG after conjugation with GF3 were bigger than that with GF4, including quenching of fluorescence intensity, the red-shift of fluorescence spectra, and the increase in sulfhydryl content.	Sulfhydryl Compounds	221-231	beta-lactoglobulin	Bos taurus	48-55
26513450-7	2015	This is because disulfide bonds are stable in most blood pools but are efficiently cleaved by cellular thiols, including glutathione (GSH) and thioredoxin (Trx), which are generally found at elevated levels in tumors.	Sulfhydryl Compounds	103-109	thioredoxin	Homo sapiens	143-154
26453916-13	2015	The current study raises significant questions about the reported ability of H2S to activate GAPDH by the sulfuration of its active site thiol, and indicates that polysulfide is a stronger protein S-sulfurating agent than sulfide.	Sulfhydryl Compounds	137-142	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	93-98
26408225-0	2015	Thiol dependent NF-kappaB suppression and inhibition of T-cell mediated adaptive immune responses by a naturally occurring steroidal lactone Withaferin A.	Sulfhydryl Compounds	0-5	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	16-25
26453922-0	2015	Plasma protein thiolation index (PTI) as a biomarker of thiol-specific oxidative stress in haemodialyzed patients.	Sulfhydryl Compounds	15-20	serpin family B member 6	Homo sapiens	33-36
26453922-7	2015	Additionally, we determined protein thiolation index (PTI), i.e., the molar ratio between the sum of all low molecular mass thiols bound to S-thiolated plasma proteins and protein free cysteinyl residues.	Sulfhydryl Compounds	124-130	serpin family B member 6	Homo sapiens	54-57
26453922-9	2015	Although this study is limited in size, our results suggest that PTI is a useful indicator of thiol-specific oxidative stress in patients with ESRD on maintenance HD.	Sulfhydryl Compounds	94-99	serpin family B member 6	Homo sapiens	65-68
26453922-10	2015	This study also emphasizes that PTI determination is a cheap and simple tool suitable for large-scale clinical studies that could be used for routine screening of thiol-specific oxidative stress.	Sulfhydryl Compounds	163-168	serpin family B member 6	Homo sapiens	32-35
26513450-7	2015	This is because disulfide bonds are stable in most blood pools but are efficiently cleaved by cellular thiols, including glutathione (GSH) and thioredoxin (Trx), which are generally found at elevated levels in tumors.	Sulfhydryl Compounds	103-109	thioredoxin	Homo sapiens	156-159
26451472-11	2015	Inhibition of the Trx system by HN2 can disrupt cellular thiol-disulfide balance, contributing to vesicant-induced lung toxicity.	Sulfhydryl Compounds	57-62	thioredoxin	Homo sapiens	18-21
26451472-11	2015	Inhibition of the Trx system by HN2 can disrupt cellular thiol-disulfide balance, contributing to vesicant-induced lung toxicity.	Sulfhydryl Compounds	57-62	MT-RNR2 like 2 (pseudogene)	Homo sapiens	32-35
26664998-4	2015	There is evidence for aberrant thiol oxidation within mHTT and other proteins in HD models.	Sulfhydryl Compounds	31-36	huntingtin	Mus musculus	54-58
26483203-3	2015	JX06 forms a disulfide bond with the thiol group of a conserved cysteine residue (C240) based on recognition of a hydrophobic pocket adjacent to the ATP pocket of the PDK1 enzyme.	Sulfhydryl Compounds	37-42	pyruvate dehydrogenase kinase 1	Homo sapiens	167-171
26562652-3	2015	The interleukin-4 (IL-4) pathway, which has previously been reported to induce reactive oxygen species and oxidation of PTP1B, may be controlled by several other putative mechanisms of redox regulation; widespread proteomic thiol oxidation observed via 2D redox differential gel electrophoresis upon IL-4 treatment suggests more than one redox-sensitive protein implicated in this pathway.	Sulfhydryl Compounds	224-229	interleukin 4	Homo sapiens	4-17
26562652-3	2015	The interleukin-4 (IL-4) pathway, which has previously been reported to induce reactive oxygen species and oxidation of PTP1B, may be controlled by several other putative mechanisms of redox regulation; widespread proteomic thiol oxidation observed via 2D redox differential gel electrophoresis upon IL-4 treatment suggests more than one redox-sensitive protein implicated in this pathway.	Sulfhydryl Compounds	224-229	interleukin 4	Homo sapiens	19-23
26327594-6	2015	However, in 5-LO/FLAP-transfected HeLa cells, treatment with the thiol-oxidizing agent diamide which promotes glutathionylation at surface Cys residues led to a decreased LT synthesis by 5-LO WT.	Sulfhydryl Compounds	65-70	arachidonate 5-lipoxygenase activating protein	Homo sapiens	17-21
26123438-0	2015	Tip-enhanced Raman spectroscopic imaging shows segregation within binary self-assembled thiol monolayers at ambient conditions.	Sulfhydryl Compounds	88-93	TOR signaling pathway regulator	Homo sapiens	0-3
26123438-1	2015	Phase segregation of coadsorbed thiol molecules on a gold surface was investigated with nanoscale chemical imaging using tip-enhanced Raman spectroscopy (TERS).	Sulfhydryl Compounds	32-37	TOR signaling pathway regulator	Homo sapiens	121-124
26441309-0	2015	Free Thiol of Transthyretin in Human Plasma Most Accessible to Modification/Oxidation.	Sulfhydryl Compounds	5-10	transthyretin	Homo sapiens	14-27
26441309-6	2015	However, contrary to our expectations, transthyretin (TTR), which also has a single free thiol, was found to be the major protein that was the most susceptible to modification/oxidation.	Sulfhydryl Compounds	89-94	transthyretin	Homo sapiens	39-52
26441309-6	2015	However, contrary to our expectations, transthyretin (TTR), which also has a single free thiol, was found to be the major protein that was the most susceptible to modification/oxidation.	Sulfhydryl Compounds	89-94	transthyretin	Homo sapiens	54-57
26441309-8	2015	The findings show that the levels of the free-thiol form of TTR in plasma was significantly lowered after a hydrogen peroxide treatment, even at low concentrations (0.1 mM), suggesting that TTR could be a useful biomarker for monitoring a ROS imbalance in relation to various oxidative stress conditions.	Sulfhydryl Compounds	46-51	transthyretin	Homo sapiens	60-63
26441309-8	2015	The findings show that the levels of the free-thiol form of TTR in plasma was significantly lowered after a hydrogen peroxide treatment, even at low concentrations (0.1 mM), suggesting that TTR could be a useful biomarker for monitoring a ROS imbalance in relation to various oxidative stress conditions.	Sulfhydryl Compounds	46-51	transthyretin	Homo sapiens	190-193
26377309-2	2015	We reported recently that YajL and DJ-1 protect cells against oxidative stress-induced protein aggregation by acting as covalent chaperones for the thiol proteome, including the NuoG subunit of NADH dehydrogenase 1, and that NADH dehydrogenase 1 activity is negligible in the yajL mutant.	Sulfhydryl Compounds	148-153	Parkinsonism associated deglycase	Homo sapiens	35-39
26235932-9	2015	CONCLUSIONS: In MHD, markers of thiol oxidation including CySSP and PTI show independent association with dietary intake and NGAL, whereas PSH, a marker of thiol-reducing capacity, did not associate with these same variables.	Sulfhydryl Compounds	32-37	lipocalin 2	Homo sapiens	125-129
26338951-1	2015	Two different thiol redox systems exist in plant chloroplasts, the ferredoxin-thioredoxin (Trx) system, which depends on ferredoxin reduced by the photosynthetic electron transport chain and, thus, on light, and the NADPH-dependent Trx reductase C (NTRC) system, which relies on NADPH and thus may be linked to sugar metabolism in the dark.	Sulfhydryl Compounds	14-19	NADPH-dependent thioredoxin reductase C	Arabidopsis thaliana	216-247
26310710-7	2015	Interestingly, this sulforaphane metabolite-induced PARP-1 inhibition was prevented by thiol compounds.	Sulfhydryl Compounds	87-92	poly(ADP-ribose) polymerase 1	Homo sapiens	52-58
26338951-1	2015	Two different thiol redox systems exist in plant chloroplasts, the ferredoxin-thioredoxin (Trx) system, which depends on ferredoxin reduced by the photosynthetic electron transport chain and, thus, on light, and the NADPH-dependent Trx reductase C (NTRC) system, which relies on NADPH and thus may be linked to sugar metabolism in the dark.	Sulfhydryl Compounds	14-19	NADPH-dependent thioredoxin reductase C	Arabidopsis thaliana	249-253
26338951-8	2015	Results provide genetic evidence that light- and NADPH-dependent thiol redox systems interact at the level of Trx f1 and NTRC to coordinately participate in the regulation of the Calvin-Benson cycle, starch metabolism, and growth in response to varying light conditions.	Sulfhydryl Compounds	65-70	NADPH-dependent thioredoxin reductase C	Arabidopsis thaliana	121-125
26387864-2	2015	Here, we investigated the interactome of Mia40 thereby revealing links between thiol-oxidation and apoptosis, energy metabolism, and Ca(2+) signaling.	Sulfhydryl Compounds	79-84	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	41-46
27006709-11	2015	However, an increase in non-protein thiols may be an important factor that compensates for the decrease of superoxide dismutase and catalase activity in the oldest rats, to maintain appropriate antioxidant defenses against oxidative insults.	Sulfhydryl Compounds	36-42	catalase	Rattus norvegicus	132-140
26617971-0	2015	Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function.	Sulfhydryl Compounds	0-5	histone deacetylase 6	Rattus norvegicus	33-38
26206888-8	2015	In conclusion, NAC is a useful source of sulfate for macromolecular sulfation in vivo when extracellular sulfate supply is reduced, confirming the potential of therapeutic approaches with thiol compounds to improve skeletal deformity and short stature in human DTD and related disorders.	Sulfhydryl Compounds	188-193	X-linked Kx blood group	Homo sapiens	15-18
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	40-45	thioredoxin 1	Mus musculus	111-122
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	40-45	thioredoxin 1	Mus musculus	124-128
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	40-45	mitogen-activated protein kinase kinase kinase 5	Mus musculus	187-191
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	40-45	glutathione S-transferase, mu 1	Mus musculus	199-232
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	40-45	glutathione S-transferase, mu 1	Mus musculus	234-239
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	40-45	mitogen-activated protein kinase kinase kinase 5	Mus musculus	286-290
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	79-84	thioredoxin 1	Mus musculus	111-122
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	79-84	thioredoxin 1	Mus musculus	124-128
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	79-84	mitogen-activated protein kinase kinase kinase 5	Mus musculus	187-191
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	79-84	glutathione S-transferase, mu 1	Mus musculus	199-232
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	79-84	glutathione S-transferase, mu 1	Mus musculus	234-239
26164633-4	2015	This occurred through selective protein thiol oxidation of the redox-sensitive thiol disulfide oxidoreductase, thioredoxin (Trx1), resulting in release of its inhibitory association with ASK1, while glutathione-S-transferase micro 1 (GSTM1) remained in reduced form in association with ASK1.	Sulfhydryl Compounds	79-84	mitogen-activated protein kinase kinase kinase 5	Mus musculus	286-290
26164633-8	2015	Averting an early increase in TNF, which leads to protein thiol oxidation resulting in activation of ASK1-p38 signaling, may be critical for neuroprotection in PD.	Sulfhydryl Compounds	58-63	tumor necrosis factor	Mus musculus	30-33
26234586-6	2015	Tryptophan fluorescence spectroscopy and thiol crosslinking analyzed by mass spectrometry also demonstrate that M26I DJ-1 samples conformations that differ from the wild-type protein at 37 C. These transiently sampled conformations are unstable and cause M26I DJ-1 to aggregate in vitro at physiological temperature but not at lower temperatures.	Sulfhydryl Compounds	41-46	Parkinsonism associated deglycase	Homo sapiens	117-121
26111761-6	2015	Farrerol down-regulated the expression of the Keap1 protein and the thiol reducing agents attenuated farrerol-induced HO-1 expression.	Sulfhydryl Compounds	68-73	heme oxygenase 1	Mus musculus	118-122
26406477-4	2015	Although SBP(A18C) binds to SAVSBPM32 more weakly than SBP-tag, the binding affinity is sufficient to bring the two binding partners together efficiently before they are locked together via disulfide bond formation-a phenomenon we have named affinity-driven thiol coupling.	Sulfhydryl Compounds	258-263	selenium binding protein 1	Homo sapiens	9-13
26406477-4	2015	Although SBP(A18C) binds to SAVSBPM32 more weakly than SBP-tag, the binding affinity is sufficient to bring the two binding partners together efficiently before they are locked together via disulfide bond formation-a phenomenon we have named affinity-driven thiol coupling.	Sulfhydryl Compounds	258-263	selenium binding protein 1	Homo sapiens	9-12
25985065-4	2015	First, thiol functionalized capture probes (C1 and C2) were severally assembled onto two different gold electrodes, followed by hybridizing with target dsDNA (S1a-S1b) and assistant probes to form two Y-junction-structure ternary complexes.	Sulfhydryl Compounds	7-12	complement C2	Equus caballus	44-53
26296460-3	2015	Each iron of the iron-sulfur clusters is bound to the thiols of the cysteines, one of which is from the active site of GLRX3, the other from the noncovalently bound GSH.	Sulfhydryl Compounds	54-60	glutaredoxin 3	Homo sapiens	119-124
26396244-10	2015	Thus, we propose that the N-terminal domain of BAD-1 governs the initial association with host GAGs and that proximity to GAG-associated host PDI catalyzes activation of additional binding motifs conserved within the tandem repeats, leading to enhanced avidity and availability of reduced thiols.	Sulfhydryl Compounds	289-295	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	142-145
26367870-3	2015	This study presents data testing two main hypotheses: 1) that specific thiol-disulfide exchange in AtSS1 influences its catalytic function 2) that each conserved Cys residue has an impact on AtSS1 catalysis.	Sulfhydryl Compounds	71-76	Glycogen/starch synthases, ADP-glucose type	Arabidopsis thaliana	99-104
26094816-4	2015	Indeed, investigations in animal models have suggested that one of the most important thiol-dependent antioxidant enzymes, peroxiredoxin 1 (PRDX1), is essential for NK cell function.	Sulfhydryl Compounds	86-91	peroxiredoxin 1	Homo sapiens	123-138
26278410-2	2015	The modified n-GO was subsequently conjugated to a mucin 1 receptor immunoglobulin G antibody (anti-MUC1 IgG) via thiol-ene coupling reaction.	Sulfhydryl Compounds	114-119	mucin 1, cell surface associated	Homo sapiens	100-104
26077311-6	2015	Sustained FGE activity further requires the presence of a thiol-based reductant such as DTT.	Sulfhydryl Compounds	58-63	sulfatase modifying factor 1	Homo sapiens	10-13
25985912-6	2015	Confocal laser scanning microscopy (CLSM) and fluorescence-activated cell sorting (FACS) showed that MSN-SS-HA exhibited a higher cellular uptake via cluster of differentiation antigen-44 (CD44) receptor-mediated endocytosis compared with thiol (SH)-functionalized MSN (MSN-SH) in CD44 receptor over-expressed in human HCT-116 cells.	Sulfhydryl Compounds	239-244	moesin	Homo sapiens	101-104
25985912-6	2015	Confocal laser scanning microscopy (CLSM) and fluorescence-activated cell sorting (FACS) showed that MSN-SS-HA exhibited a higher cellular uptake via cluster of differentiation antigen-44 (CD44) receptor-mediated endocytosis compared with thiol (SH)-functionalized MSN (MSN-SH) in CD44 receptor over-expressed in human HCT-116 cells.	Sulfhydryl Compounds	239-244	CD44 molecule (Indian blood group)	Homo sapiens	189-193
26070641-9	2015	KEY RESULTS: In comparison with wild-type plants, elevated basal thiol levels and enhanced PC synthesis upon exposure to Cd efficiently compensated AsA deficiency in vtc1-1 plants and contributed to decreased sensitivity towards Cd.	Sulfhydryl Compounds	65-70	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	166-172
26094816-4	2015	Indeed, investigations in animal models have suggested that one of the most important thiol-dependent antioxidant enzymes, peroxiredoxin 1 (PRDX1), is essential for NK cell function.	Sulfhydryl Compounds	86-91	peroxiredoxin 1	Homo sapiens	140-145
26094816-7	2015	To study the role of thiol-dependent antioxidants in more detail, we applied a novel compound, adenanthin, to induce an abrupt dysfunction of the PRDX-related antioxidant chain in NK cells.	Sulfhydryl Compounds	21-26	peroxiredoxin 1	Homo sapiens	146-150
26213805-4	2015	It is observed that the Au25(PPh3)10(SR1)5X2 nanorods cannot convert to Au25(SR)18 nanospheres in the presence of excess thiol (both the alkyl and aromatic thiol) even under thermal conditions (e.g., 55 and 80  C), indicating that both the Au25 nanorods and nanospheres are in a stable state during the alkyl and aromatic thiol etching reactions, respectively.	Sulfhydryl Compounds	121-126	protein phosphatase 4 catalytic subunit	Homo sapiens	29-33
25586108-6	2015	Thiol metabolic enzymes such as cysteine synthase, gamma-glutamylcysteine synthetase, and glutathione synthetase, and compounds such as cysteine, glutathione, and non-protein thiols were stimulated by As(V) stress.	Sulfhydryl Compounds	0-5	glutathione synthetase	Homo sapiens	90-112
25670482-6	2015	Along with the aldehyde-amino group interaction, thiol groups were also involved in the binding between alcohol dehydrogenase and carbohydrates.	Sulfhydryl Compounds	49-54	aldo-keto reductase family 1 member A1	Homo sapiens	104-125
26187140-2	2015	In this paper, the use of monodentate thiol ligands RSH as light-cleavable protecting groups for the ruthenium complex [Ru(tpy)(bpy)(OH2)](PF6)2 ([1](PF6)2; tpy=2,2";6",2""-terpyridine, bpy=2,2"-bypyridine), is investigated.	Sulfhydryl Compounds	38-43	sperm associated antigen 17	Homo sapiens	139-142
26187140-2	2015	In this paper, the use of monodentate thiol ligands RSH as light-cleavable protecting groups for the ruthenium complex [Ru(tpy)(bpy)(OH2)](PF6)2 ([1](PF6)2; tpy=2,2";6",2""-terpyridine, bpy=2,2"-bypyridine), is investigated.	Sulfhydryl Compounds	38-43	sperm associated antigen 17	Homo sapiens	150-153
26187140-4	2015	Coordination of the monodentate thiol ligands to the ruthenium complex takes place upon heating to 353 K, but full conversion to the protected complex [Ru(tpy)(bpy)(SR)]PF6 is only possible when a large excess of ligand is used.	Sulfhydryl Compounds	32-37	sperm associated antigen 17	Homo sapiens	169-172
26213805-4	2015	It is observed that the Au25(PPh3)10(SR1)5X2 nanorods cannot convert to Au25(SR)18 nanospheres in the presence of excess thiol (both the alkyl and aromatic thiol) even under thermal conditions (e.g., 55 and 80  C), indicating that both the Au25 nanorods and nanospheres are in a stable state during the alkyl and aromatic thiol etching reactions, respectively.	Sulfhydryl Compounds	156-161	protein phosphatase 4 catalytic subunit	Homo sapiens	29-33
26213805-4	2015	It is observed that the Au25(PPh3)10(SR1)5X2 nanorods cannot convert to Au25(SR)18 nanospheres in the presence of excess thiol (both the alkyl and aromatic thiol) even under thermal conditions (e.g., 55 and 80  C), indicating that both the Au25 nanorods and nanospheres are in a stable state during the alkyl and aromatic thiol etching reactions, respectively.	Sulfhydryl Compounds	156-161	protein phosphatase 4 catalytic subunit	Homo sapiens	29-33
26312482-1	2015	OBJECTIVE: Angiotensinogen exists in two distinct redox forms in plasma, the oxidized sulfhydryl-bridge form and the reduced, unbridged, free thiol form.	Sulfhydryl Compounds	142-147	angiotensinogen	Homo sapiens	11-26
26312482-2	2015	The oxidized form of angiotensinogen compared to the free thiol form preferentially interacts with renin resulting in increased generation of angiotensin.	Sulfhydryl Compounds	58-63	angiotensinogen	Homo sapiens	21-36
26312482-2	2015	The oxidized form of angiotensinogen compared to the free thiol form preferentially interacts with renin resulting in increased generation of angiotensin.	Sulfhydryl Compounds	58-63	renin	Homo sapiens	99-104
26312482-7	2015	The oxidized angiotensinogen plasma level is derived by subtracting the level of free thiol, reduced angiotensinogen from the total angiotensinogen levels in the plasma.	Sulfhydryl Compounds	86-91	angiotensinogen	Homo sapiens	13-28
26093341-9	2015	The number of CD133(+)/CD34(+) (%) negatively correlated with both age and mO2 of &lt;90% but positively correlated with thiols.	Sulfhydryl Compounds	121-127	CD34 molecule	Homo sapiens	23-27
26312482-10	2015	CONCLUSION: Patients with pre-eclampsia had substantially lower levels of free thiol angiotensinogen compared to healthy pregnant controls, whilst maintaining similar total angiotensinogen levels in the plasma.	Sulfhydryl Compounds	79-84	angiotensinogen	Homo sapiens	85-100
26205490-3	2015	Furthermore, sustained activation of thiol redox networks by KEAP1-NRF2 induces a reductive stress, by decreasing the lifetime of necessary oxidative post-translational modifications required for normal metabolism or cell signalling.	Sulfhydryl Compounds	37-42	kelch like ECH associated protein 1	Homo sapiens	61-66
26214018-10	2015	The solution NMR structure of Mia40 (and supporting biochemical experiments) showed that Mia40 is a novel type of disulfide donor whose recognition capacity for its substrates relies on a hydrophobic binding cleft found adjacent to a thiol active CPC motif.	Sulfhydryl Compounds	234-239	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	30-35
26214018-10	2015	The solution NMR structure of Mia40 (and supporting biochemical experiments) showed that Mia40 is a novel type of disulfide donor whose recognition capacity for its substrates relies on a hydrophobic binding cleft found adjacent to a thiol active CPC motif.	Sulfhydryl Compounds	234-239	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	89-94
26523134-4	2015	The inclusion of thiols from a pair of cysteine residues in the ELP sequence allows disulfide bond formation upon exposure to UV light, leading to the formation of a highly elastic hydrogel.	Sulfhydryl Compounds	17-23	diazepam binding inhibitor-like 5	Rattus norvegicus	64-67
26116162-0	2015	Celastrol blocks binding of lipopolysaccharides to a Toll-like receptor4/myeloid differentiation factor2 complex in a thiol-dependent manner.	Sulfhydryl Compounds	118-123	toll-like receptor 4	Mus musculus	53-72
26116162-10	2015	The inhibitory effects of celastrol on LPS binding to MD2 were reversed by thiol donors (N-acetyl-L-cysteine and dithiothreitol), suggesting that the thiol reactivity of celastrol contributes to its inhibitory effects on TLR4 activation in macrophages.	Sulfhydryl Compounds	75-80	lymphocyte antigen 96	Mus musculus	54-57
26116162-10	2015	The inhibitory effects of celastrol on LPS binding to MD2 were reversed by thiol donors (N-acetyl-L-cysteine and dithiothreitol), suggesting that the thiol reactivity of celastrol contributes to its inhibitory effects on TLR4 activation in macrophages.	Sulfhydryl Compounds	150-155	lymphocyte antigen 96	Mus musculus	54-57
26254269-0	2015	Thioredoxin selectivity for thiol-based redox regulation of target proteins in chloroplasts.	Sulfhydryl Compounds	28-33	thioredoxin	Homo sapiens	0-11
26166150-0	2015	Development of a Method for the Quantitation of Three Thiols in Beer, Hop, and Wort Samples by Stir Bar Sorptive Extraction with in Situ Derivatization and Thermal Desorption-Gas Chromatography-Tandem Mass Spectrometry.	Sulfhydryl Compounds	54-60	HOP homeobox	Homo sapiens	70-73
26166150-1	2015	A method for analysis of hop-derived polyfunctional thiols, such as 4-sulfanyl-4-methylpentan-2-one (4S4M2Pone), 3-sulfanylhexan-1-ol (3SHol), and 3-sulfanylhexyl acetate (3SHA), in beer, hop water extract, and wort at nanogram per liter levels was developed.	Sulfhydryl Compounds	52-58	HOP homeobox	Homo sapiens	25-28
26166150-7	2015	The method was successfully applied to the determination of target thiols at nanogram per liter levels in three kinds of beer samples (hopped with Cascade, Citra, and Nelson Sauvin) and the corresponding hop water extracts and wort samples.	Sulfhydryl Compounds	67-73	HOP homeobox	Homo sapiens	135-138
26205490-3	2015	Furthermore, sustained activation of thiol redox networks by KEAP1-NRF2 induces a reductive stress, by decreasing the lifetime of necessary oxidative post-translational modifications required for normal metabolism or cell signalling.	Sulfhydryl Compounds	37-42	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71
26205490-7	2015	Recent studies indicate that the modification of protein thiols plays an important role in the regulation of both the KEAP1-NRF2 and autophagy pathways.	Sulfhydryl Compounds	57-63	kelch like ECH associated protein 1	Homo sapiens	118-123
26048438-5	2015	On the contrary, levels of non-protein thiols were enhanced by 3-11.8 time over control in response to 16-80 mg L(-1) Pb2+ treatment, after 24 h. A dose-dependent induction in ascorbate peroxidase and lipoxygenase enzyme activity was observed in Z. mays roots.	Sulfhydryl Compounds	39-45	peroxidase 1	Zea mays	186-196
26205490-7	2015	Recent studies indicate that the modification of protein thiols plays an important role in the regulation of both the KEAP1-NRF2 and autophagy pathways.	Sulfhydryl Compounds	57-63	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
31973290-2	2015	A novel bis-alkylation reagent is synthesized that facilitates the functionalization of SST with a thiol anchor.	Sulfhydryl Compounds	99-104	somatostatin	Homo sapiens	88-91
26165646-6	2015	These data suggested that the reaction of DHP with a thiol moiety could be involved in oxidative stress, because an increase in the amount of DHP-GSH adducts would result in a decrease in the cellular GSH levels.	Sulfhydryl Compounds	53-58	dihydropyrimidinase	Homo sapiens	42-45
25952364-5	2015	The CAV was found to reduce the cellular antioxidant enzymes such as SOD and CAT, and there was a significant decrease in total thiol level and mtDNA integrity, and it enhanced the lipid peroxidation.	Sulfhydryl Compounds	128-133	caveolin 2	Homo sapiens	4-7
26038341-4	2015	A full-length copy of IRC7 is absolutely required for the cleavage of both precursors in the tested strains; the deleted form of the enzyme found in most yeast strains is incapable of converting these compounds into detectable thiols.	Sulfhydryl Compounds	227-233	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	22-26
26038341-5	2015	By using strains that overexpress full-length IRC7, we further show that the glutathione transporter OPT1 and the transpeptidase CIS2 are also required for conversion of glut-3MH to its varietal thiol.	Sulfhydryl Compounds	195-200	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	46-50
26038341-5	2015	By using strains that overexpress full-length IRC7, we further show that the glutathione transporter OPT1 and the transpeptidase CIS2 are also required for conversion of glut-3MH to its varietal thiol.	Sulfhydryl Compounds	195-200	oligopeptide transporter OPT1	Saccharomyces cerevisiae S288C	101-105
26165646-6	2015	These data suggested that the reaction of DHP with a thiol moiety could be involved in oxidative stress, because an increase in the amount of DHP-GSH adducts would result in a decrease in the cellular GSH levels.	Sulfhydryl Compounds	53-58	dihydropyrimidinase	Homo sapiens	142-145
25720945-1	2015	BACKGROUND: The thiol protein peroxiredoxin 2 (Prx2) is a major red blood cell (RBC) antioxidant that breaks down hydroperoxides and in the process is converted to an oxidized disulfide.	Sulfhydryl Compounds	16-21	peroxiredoxin 2	Homo sapiens	47-51
26114584-3	2015	Consistent with TAK1 inhibition being causally related to thiol-mediated oxidative stress, 10mM N-acetylcysteine (NAC) partially reversed the growth inhibitory effects of 5Z-7-oxozeaenol.	Sulfhydryl Compounds	58-63	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	16-20
26114584-8	2015	These results support the hypothesis that thiol-mediated oxidative stress is causally related to TAK1-induced colon cancer cell killing.	Sulfhydryl Compounds	42-47	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	97-101
24811047-3	2015	The probe, CPM (7-diethylamino-3-(4-maleimido-phenyl)-4-methylcoumarin), binds with the free thiol groups.	Sulfhydryl Compounds	93-98	carboxypeptidase M	Homo sapiens	11-14
25720945-1	2015	BACKGROUND: The thiol protein peroxiredoxin 2 (Prx2) is a major red blood cell (RBC) antioxidant that breaks down hydroperoxides and in the process is converted to an oxidized disulfide.	Sulfhydryl Compounds	16-21	peroxiredoxin 2	Homo sapiens	30-45
26177047-6	2015	In contrast, CstB oxidizes major cellular low molecular weight (LMW) persulfide substrates from S. aureus, coenzyme A persulfide (CoASSH) and bacillithiol persulfide (BSSH), directly to generate thiosulfate (TS) and reduced thiols, thereby avoiding the cellular toxicity of sulfite.	Sulfhydryl Compounds	224-230	cystatin B	Homo sapiens	13-17
26115003-2	2015	These and related compounds were evaluated for modulation of a series of thiol trapping-sensitive transcription factors (NF-kappaB, STAT3, and Nrf2), involved in the maintenance of the chronic inflammatory condition typical of human degenerative diseases.	Sulfhydryl Compounds	73-78	nuclear factor kappa B subunit 1	Homo sapiens	121-130
26115003-2	2015	These and related compounds were evaluated for modulation of a series of thiol trapping-sensitive transcription factors (NF-kappaB, STAT3, and Nrf2), involved in the maintenance of the chronic inflammatory condition typical of human degenerative diseases.	Sulfhydryl Compounds	73-78	signal transducer and activator of transcription 3	Homo sapiens	132-137
26115003-2	2015	These and related compounds were evaluated for modulation of a series of thiol trapping-sensitive transcription factors (NF-kappaB, STAT3, and Nrf2), involved in the maintenance of the chronic inflammatory condition typical of human degenerative diseases.	Sulfhydryl Compounds	73-78	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
24811047-10	2015	In both of the cells (MCF-10A and MCF-7) CPM bound to thiol-containing proteins in mitochondria exhibits ultraslow response with average solvation time ((taus)) of 850 and 1400 ps in MCF-10A and MCF-7, respectively.	Sulfhydryl Compounds	54-59	carboxypeptidase M	Homo sapiens	41-44
26006777-5	2015	This Ge-S coupling reaction shows high generality for the variety of thiols.	Sulfhydryl Compounds	69-75	RRAD and GEM like GTPase 1	Homo sapiens	5-9
25989104-0	2015	Thiol-disulfide exchange between the PDI family of oxidoreductases negates the requirement for an oxidase or reductase for each enzyme.	Sulfhydryl Compounds	0-5	prolyl 4-hydroxylase subunit beta	Homo sapiens	37-40
25989104-7	2015	These results have allowed us to define a hierarchy for members of the PDI family, in terms of ability to act as electron acceptors or donors during thiol-disulfide exchange reactions and indicate that there is no kinetic barrier to the exchange of disulfides between several PDI proteins.	Sulfhydryl Compounds	149-154	prolyl 4-hydroxylase subunit beta	Homo sapiens	71-74
25980911-0	2015	Enrichment of O-GlcNAc-modified peptides using novel thiol-alkyne and thiol-disulfide exchange.	Sulfhydryl Compounds	53-58	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	14-22
25980911-0	2015	Enrichment of O-GlcNAc-modified peptides using novel thiol-alkyne and thiol-disulfide exchange.	Sulfhydryl Compounds	70-75	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	14-22
25980911-1	2015	We have developed a selective method for the enrichment of O-linked beta-N-acetylglucosamine (O-GlcNAc)-modified peptides, which uses a newly synthesized thiol-alkyne and a thiol-disulfide exchange.	Sulfhydryl Compounds	154-159	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	59-102
26236095-5	2015	We hypothesized that MnSOD regulates intracellular reduced thiol status and promotes cancer invasion.	Sulfhydryl Compounds	59-64	superoxide dismutase 2	Rattus norvegicus	21-26
26039939-3	2015	A proposed reaction scheme involves the peptide-channel complex stabilized by a disulfide bond formed via thiol-disulfide exchange between Cys24 of the peptide and a Cys residue at neurotoxin receptor site 8 in the pore module of the channel (specifically, Cys910 of rat NaV1.2).	Sulfhydryl Compounds	106-111	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	271-277
26039939-9	2015	The results indicate that Cys910 in wild-type NaV1.2 has a free thiol and conversely suggest that in NaV1.2[C912A] and NaV1.2[C918A], Cys910 is disulfide-bonded to Cys918 and Cys912, respectively.	Sulfhydryl Compounds	64-69	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	46-52
26039939-9	2015	The results indicate that Cys910 in wild-type NaV1.2 has a free thiol and conversely suggest that in NaV1.2[C912A] and NaV1.2[C918A], Cys910 is disulfide-bonded to Cys918 and Cys912, respectively.	Sulfhydryl Compounds	64-69	neuron navigator 1	Rattus norvegicus	46-50
26035464-2	2015	To reverse the drug resistance, two thiol-modified peptide sequences HAIYPRHGGC and THRPPMWSPVWPGGC were, respectively, conjugated to DOXO-EMCH, forming a maleimide bridge in this study (i.e., T10-DOX and T15-DOX).	Sulfhydryl Compounds	36-41	transport and golgi organization 2	Mus musculus	193-200
25841785-3	2015	Low molecular mass thiol compounds, including glutathione (GSH) and methionine (Met), have demonstrated efficacy in scavenging MPO-derived oxidants, which prevents oxidative damage in vitro and ex vivo.	Sulfhydryl Compounds	19-24	myeloperoxidase	Homo sapiens	127-130
25926547-3	2015	Thioredoxin system not only plays a crucial role as thiol/disulfide redox controller, it is also essential for certain organisms as the only system ensuring the redox homeostasis.	Sulfhydryl Compounds	52-57	thioredoxin	Homo sapiens	0-11
25871637-7	2015	While IRC7 has been identified as playing a critical role in converting cysteine conjugates to volatile thiols that are important in wine aroma, its biological role in yeast cells is likely to involve regulation of cysteine and redox homeostasis.	Sulfhydryl Compounds	104-110	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	6-10
25735211-1	2015	BACKGROUND: Thioredoxin (Trx) family proteins are crucial mediators of cell functions via regulation of the thiol redox state of various key proteins and the levels of the intracellular second messenger hydrogen peroxide.	Sulfhydryl Compounds	108-113	thioredoxin	Homo sapiens	12-23
26024338-6	2015	The observation that these positions are inaccessible to channel-permeant thiol-specific reagent [Au(CN)2]- suggests that this segment of TM5 between F311 and L323 is concealed from the pore by other TMs and/or lipid bilayers.	Sulfhydryl Compounds	74-79	tropomyosin 3	Homo sapiens	138-141
25978737-3	2015	In this study, we engineered original cysteine positional variants of a Fab fragment, with less than 20% of ASA, and evaluated their thiol reactivities through conjugation with various kinds of payloads.	Sulfhydryl Compounds	133-138	FA complementation group B	Homo sapiens	72-75
25965413-3	2015	Protonation of the arylthiolate-ligated [4Fe-4S] cluster [Fe4 S4 (SAr)4 ](2-) (1, SAr=S-2,4-6-(iPr)3 C6 H2 ) leads to thiol dissociation, reversibly forming [Fe4 S4 (SAr)3 L](1-) (2) and ArSH (L=solvent, and/or conjugate base).	Sulfhydryl Compounds	23-28	arylsulfatase family member H	Homo sapiens	187-191
25922076-10	2015	Because the stability of the mitochondrial capsule of mature spermatozoa depends on the moonlighting function of Gpx4 both as an enzyme oxidizing capsular protein thiols and as a structural protein, tightly controlled expression of functional Gpx4 emerges as a key for full male fertility.	Sulfhydryl Compounds	163-169	glutathione peroxidase 4	Mus musculus	113-117
25613813-4	2015	For the detection systems, the thiol-containing amino acid, L-Cysteine, was self-assembled onto smooth gold electrodes and functionalized with anti-EpCAM.	Sulfhydryl Compounds	31-36	epithelial cell adhesion molecule	Homo sapiens	148-153
25878252-0	2015	Thioredoxin Selectivity for Thiol-based Redox Regulation of Target Proteins in Chloroplasts.	Sulfhydryl Compounds	28-33	thioredoxin H-type 1	Arabidopsis thaliana	0-11
25878252-3	2015	To directly address this issue, we studied the Trx-dependent redox shifts of several chloroplast thiol-modulated enzymes in vitro and in vivo.	Sulfhydryl Compounds	97-102	thioredoxin H-type 1	Arabidopsis thaliana	47-50
25878252-6	2015	In our in vitro assays, Trx-f was effective in reducing all thiol-modulated enzymes analyzed here.	Sulfhydryl Compounds	60-65	thioredoxin H-type 1	Arabidopsis thaliana	24-27
25878252-8	2015	Photoreduction of fructose-1,6-bisphosphatase was partially impaired in Trx-f-deficient plants, but the global impact of Trx-f deficiency on the redox behaviors of thiol-modulated enzymes was not as striking as expected from the in vitro data.	Sulfhydryl Compounds	164-169	thioredoxin H-type 1	Arabidopsis thaliana	121-124
25735211-1	2015	BACKGROUND: Thioredoxin (Trx) family proteins are crucial mediators of cell functions via regulation of the thiol redox state of various key proteins and the levels of the intracellular second messenger hydrogen peroxide.	Sulfhydryl Compounds	108-113	thioredoxin	Homo sapiens	25-28
24285572-7	2015	A number of additional protein thiol differences in GDFs were identified, including radiation responsive annexin family members and lamin A/C.	Sulfhydryl Compounds	31-36	lamin A/C	Homo sapiens	132-141
25772009-7	2015	A comparison of ex vivo levels of disulfide homodimers of bovine recoverin with redox dependence of its in vitro thiol-disulfide equilibrium (glutathione redox pair) gives the lowest estimate of redox potential in rod outer segments under illumination from -160 to -155 mV.	Sulfhydryl Compounds	113-118	recoverin	Bos taurus	65-74
25687825-6	2015	Since the provision of low-molecular-weight thiols such as glutathione (GSH) or cysteine (Cys) by macrophages limits antigen-driven CD8(+) T cell activation, we quantified the amounts of intracellular and extracellular GSH and Cys in both cocultures.	Sulfhydryl Compounds	44-50	CD8a molecule	Homo sapiens	132-135
25687825-8	2015	Supplementation of thiols in Nrf2(-/-) cocultures via addition of glutathione ester, N-acetylcysteine, beta-mercaptoethanol, or cysteine itself restored T cell proliferation as well as cytotoxicity by increasing intracellular GSH.	Sulfhydryl Compounds	19-25	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
25687825-9	2015	Mechanistically, we identified two potential Nrf2-regulated genes involved in thiol synthesis in BMDMPhi: the cystine transporter subunit xCT and the modulatory subunit of the GSH-synthesizing enzyme gamma-GCS (GCLM).	Sulfhydryl Compounds	78-83	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
25687825-9	2015	Mechanistically, we identified two potential Nrf2-regulated genes involved in thiol synthesis in BMDMPhi: the cystine transporter subunit xCT and the modulatory subunit of the GSH-synthesizing enzyme gamma-GCS (GCLM).	Sulfhydryl Compounds	78-83	solute carrier family 7 member 11	Homo sapiens	138-141
25687825-9	2015	Mechanistically, we identified two potential Nrf2-regulated genes involved in thiol synthesis in BMDMPhi: the cystine transporter subunit xCT and the modulatory subunit of the GSH-synthesizing enzyme gamma-GCS (GCLM).	Sulfhydryl Compounds	78-83	glutamate-cysteine ligase modifier subunit	Homo sapiens	211-215
25758354-4	2015	The antioxidant capacity and thiol content of albumin from patients in advanced stages of diabetic nephropathy were markedly reduced.	Sulfhydryl Compounds	29-34	albumin	Homo sapiens	46-53
25955536-1	2015	This work describes the straightforward surface modification of 316L stainless steel with BTS, S-(11-trichlorosilylundecanyl)-benzenethiosulfonate, a thiol-reactive trichlorosilane cross-linker molecule designed to form intermediary coatings with subsequent biofunctionalization capability.	Sulfhydryl Compounds	150-155	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	90-93
25915520-10	2015	As both VIM-2 and VIM-24 were inhibited in a similar manner, the crystal structure of a VIM-2-BTZ complex was determined at 1.25 A and revealed interactions of the inhibitor thiol with the VIM Zn center.	Sulfhydryl Compounds	174-179	VIM-2	Pseudomonas aeruginosa	8-13
25915520-10	2015	As both VIM-2 and VIM-24 were inhibited in a similar manner, the crystal structure of a VIM-2-BTZ complex was determined at 1.25 A and revealed interactions of the inhibitor thiol with the VIM Zn center.	Sulfhydryl Compounds	174-179	VIM-2	Pseudomonas aeruginosa	18-23
25839660-5	2015	Trx1 prefers thiol-thioester exchange with palmitoyl-CoA to acetyl-CoA.	Sulfhydryl Compounds	13-18	thioredoxin	Homo sapiens	0-4
25713930-0	2015	Tyrosinase-catalyzed metabolism of rhododendrol (RD) in B16 melanoma cells: production of RD-pheomelanin and covalent binding with thiol proteins.	Sulfhydryl Compounds	131-136	tyrosinase	Mus musculus	0-10
25896646-6	2015	Taking advantage of these new features, we present a new scheme for the straightforward biorecognition of a lipolytic enzyme (phospholipase A2) using these phospholipid/aromatic thiol bilayers.	Sulfhydryl Compounds	178-183	phospholipase A2 group IB	Homo sapiens	126-142
25849895-4	2015	While the role of the additional N-terminal residues of HO2 is not yet understood, the HRMs have been proposed to reversibly form a thiol/disulfide redox switch that modulates the affinity of HO2 for ferric heme as a function of cellular redox poise.	Sulfhydryl Compounds	132-137	heme oxygenase 2	Homo sapiens	192-195
25825250-1	2015	Reactive oxygen species (ROS) in plants, arising from various environmental stresses, impair the thiol-contained proteins that are susceptible to irregular oxidative formation of disulfide bonds, which might be alleviated by a relatively specific modifier called protein disulfide isomerase (PDI).	Sulfhydryl Compounds	97-102	protein disulfide-isomerase	Jatropha curcas	263-290
25825250-1	2015	Reactive oxygen species (ROS) in plants, arising from various environmental stresses, impair the thiol-contained proteins that are susceptible to irregular oxidative formation of disulfide bonds, which might be alleviated by a relatively specific modifier called protein disulfide isomerase (PDI).	Sulfhydryl Compounds	97-102	protein disulfide-isomerase	Jatropha curcas	292-295
25874809-6	2015	On the basis of these studies, the most probable mechanism for the inactivation of nNOS involves oxidative demethylation with the resulting thiol coordinating to the cofactor heme iron.	Sulfhydryl Compounds	140-145	nitric oxide synthase 1	Homo sapiens	83-87
25943695-3	2015	Here we show that Prdx4, an endoplasmic reticulum (ER) enzyme that metabolizes H2O2, acts as a tunable regulator of neurogenesis via its compartmentalized thiol-oxidative function.	Sulfhydryl Compounds	155-160	peroxiredoxin 4	Homo sapiens	18-23
25914057-1	2015	Peroxiredoxins (Prxs) are a ubiquitous class of thiol-dependent peroxidases that play an important role in the protection and response of cells to oxidative stress.	Sulfhydryl Compounds	48-53	peroxiredoxin 3	Homo sapiens	0-14
25772562-1	2015	A popular thermal-stability assay developed especially for the study of membrane proteins uses a thiol-specific probe, 7-diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CPM).	Sulfhydryl Compounds	97-102	carboxypeptidase M	Homo sapiens	174-177
25778864-1	2015	We designed a straightforward biotinylated probe using the N-terminal substrate-like region of the inhibitory site of human cystatin C as a scaffold, linked to the thiol-specific reagent diazomethylketone group as a covalent warhead (i.e. Biot-(PEG)2-Ahx-LeuValGly-DMK).	Sulfhydryl Compounds	164-169	cystatin C	Homo sapiens	124-134
25778864-1	2015	We designed a straightforward biotinylated probe using the N-terminal substrate-like region of the inhibitory site of human cystatin C as a scaffold, linked to the thiol-specific reagent diazomethylketone group as a covalent warhead (i.e. Biot-(PEG)2-Ahx-LeuValGly-DMK).	Sulfhydryl Compounds	164-169	DM1 protein kinase	Homo sapiens	265-268
25754985-6	2015	Because PDI has several thiols, including thiols within the active thioredoxin-like domain, we hypothesized that PDI is a target of CyPGs and that CyPG binding of PDI is detrimental.	Sulfhydryl Compounds	24-30	prolyl 4-hydroxylase subunit beta	Homo sapiens	8-11
25754985-6	2015	Because PDI has several thiols, including thiols within the active thioredoxin-like domain, we hypothesized that PDI is a target of CyPGs and that CyPG binding of PDI is detrimental.	Sulfhydryl Compounds	24-30	prolyl 4-hydroxylase subunit beta	Homo sapiens	113-116
25754985-6	2015	Because PDI has several thiols, including thiols within the active thioredoxin-like domain, we hypothesized that PDI is a target of CyPGs and that CyPG binding of PDI is detrimental.	Sulfhydryl Compounds	24-30	prolyl 4-hydroxylase subunit beta	Homo sapiens	113-116
25754985-6	2015	Because PDI has several thiols, including thiols within the active thioredoxin-like domain, we hypothesized that PDI is a target of CyPGs and that CyPG binding of PDI is detrimental.	Sulfhydryl Compounds	42-48	prolyl 4-hydroxylase subunit beta	Homo sapiens	8-11
25754985-6	2015	Because PDI has several thiols, including thiols within the active thioredoxin-like domain, we hypothesized that PDI is a target of CyPGs and that CyPG binding of PDI is detrimental.	Sulfhydryl Compounds	42-48	prolyl 4-hydroxylase subunit beta	Homo sapiens	113-116
25754985-6	2015	Because PDI has several thiols, including thiols within the active thioredoxin-like domain, we hypothesized that PDI is a target of CyPGs and that CyPG binding of PDI is detrimental.	Sulfhydryl Compounds	42-48	prolyl 4-hydroxylase subunit beta	Homo sapiens	113-116
25737250-0	2015	Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle.	Sulfhydryl Compounds	13-18	thymoma viral proto-oncogene 1	Mus musculus	55-58
25737250-0	2015	Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle.	Sulfhydryl Compounds	13-18	phosphatase and tensin homolog	Mus musculus	60-64
25737250-0	2015	Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle.	Sulfhydryl Compounds	13-18	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	68-72
25737250-0	2015	Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle.	Sulfhydryl Compounds	13-18	thymoma viral proto-oncogene 1	Mus musculus	92-95
25737250-6	2015	This differential response could be explained: thiol oxidation of Akt, but not the phosphatases PTEN or PP2A, caused a decline in Akt phosphorylation; whereas the thiol oxidation of Akt, PTEN and PP2A increased Akt phosphorylation.	Sulfhydryl Compounds	47-52	thymoma viral proto-oncogene 1	Mus musculus	66-69
25737250-6	2015	This differential response could be explained: thiol oxidation of Akt, but not the phosphatases PTEN or PP2A, caused a decline in Akt phosphorylation; whereas the thiol oxidation of Akt, PTEN and PP2A increased Akt phosphorylation.	Sulfhydryl Compounds	47-52	thymoma viral proto-oncogene 1	Mus musculus	130-133
25737250-6	2015	This differential response could be explained: thiol oxidation of Akt, but not the phosphatases PTEN or PP2A, caused a decline in Akt phosphorylation; whereas the thiol oxidation of Akt, PTEN and PP2A increased Akt phosphorylation.	Sulfhydryl Compounds	47-52	thymoma viral proto-oncogene 1	Mus musculus	130-133
25737250-6	2015	This differential response could be explained: thiol oxidation of Akt, but not the phosphatases PTEN or PP2A, caused a decline in Akt phosphorylation; whereas the thiol oxidation of Akt, PTEN and PP2A increased Akt phosphorylation.	Sulfhydryl Compounds	47-52	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	196-200
25737250-6	2015	This differential response could be explained: thiol oxidation of Akt, but not the phosphatases PTEN or PP2A, caused a decline in Akt phosphorylation; whereas the thiol oxidation of Akt, PTEN and PP2A increased Akt phosphorylation.	Sulfhydryl Compounds	47-52	thymoma viral proto-oncogene 1	Mus musculus	130-133
25737250-6	2015	This differential response could be explained: thiol oxidation of Akt, but not the phosphatases PTEN or PP2A, caused a decline in Akt phosphorylation; whereas the thiol oxidation of Akt, PTEN and PP2A increased Akt phosphorylation.	Sulfhydryl Compounds	163-168	thymoma viral proto-oncogene 1	Mus musculus	66-69
25600998-12	2015	Taken together, these results indicate that root uptake of arsenate is probably not via sulfate transporters, but the poor growth of the double mutant of sultr1;1 and sultr1;2 was due to its poor sulfate status and decreased levels of thiols, which had pleiotropic effects on the root uptake and translocation of potassium and phosphorus and arsenic tolerance.	Sulfhydryl Compounds	235-241	sulfate transporter 1;1	Arabidopsis thaliana	154-175
25816194-5	2015	Graphene is also embedded with a trace amount of manganese impurities originating from a prior graphite oxidation process, which facilitates the thiol-functionalized graphene to function as a hybrid electrocatalyst for oxygen reduction reactions in alkaline medium with an onset potential lower than for Pt/C.	Sulfhydryl Compounds	145-150	ret proto-oncogene	Homo sapiens	304-308
25856548-4	2015	We devise a free-energy calculation scheme, which makes use of the Crooks Gaussian intersection method to estimate the redox potential of thiol/disulfide pairs in 12 proteins belonging to the thioredoxin superfamily, namely, thioredoxins, glutaredoxins, and thiol-disulfide oxidoreductases in disulfide bond formation systems.	Sulfhydryl Compounds	138-143	thioredoxin	Homo sapiens	192-203
25928076-0	2015	Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols.	Sulfhydryl Compounds	164-170	superoxide dismutase 1	Homo sapiens	19-45
25928076-0	2015	Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols.	Sulfhydryl Compounds	164-170	superoxide dismutase 1	Homo sapiens	47-51
25928076-9	2015	In contrast, DHAOOH did not induce HMW species formation but promoted abnormal covalent dimerization of apo-SOD1 that was resistant to SDS and thiol reductants.	Sulfhydryl Compounds	143-148	superoxide dismutase 1	Homo sapiens	108-112
25645953-8	2015	N-ethylmaleimide, a potent thiol modifier, completely inhibits human glutathione reductase from reducing the mitoNEET [2Fe-2S] clusters, indicating that the redox-active disulfide in the catalytic center of human glutathione reductase may be directly involved in reducing the mitoNEET [2Fe-2S] clusters.	Sulfhydryl Compounds	27-32	glutathione-disulfide reductase	Homo sapiens	69-90
25815530-3	2015	We report on the evaluation of approved thiol-containing drugs as inhibitors of NDM-1, VIM-1, and IMP-7.	Sulfhydryl Compounds	40-45	importin 7	Homo sapiens	98-103
25774882-2	2015	Using thiol-terminated short chain ethylene oxide oligomers (OEG) under aqueous conditions, we explore the creation of a model surface exhibiting resistance to nonspecific protein absorption (RPA) by engineering the surface properties of a PDA adlayer.	Sulfhydryl Compounds	6-11	replication protein A1	Homo sapiens	192-195
25023609-5	2015	Together with previous reports on the effects of related compounds on HIF-1alpha and other systems, the results suggest that care should be taken in interpreting biological results obtained with highly electrophilic/thiol modifying compounds.	Sulfhydryl Compounds	216-221	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-80
25633841-8	2015	These results informed an ongoing drug-discovery effort to identify mGluR5 PAMs with drug-like properties and a low risk of reactivity with endogenous thiols.	Sulfhydryl Compounds	151-157	glutamate receptor, ionotropic, kainate 1	Mus musculus	68-74
25785791-6	2015	The removal of surface thiol ligands from the Au NCs is crucial to catalyze nitrobenzene hydrogenation, where only calcined Au/HAP and Au/P25 exhibited good catalytic activity.	Sulfhydryl Compounds	23-28	tubulin polymerization promoting protein	Homo sapiens	135-141
25688747-2	2015	The iodo-functionalized vinylpolyethylenes (Vin-PE-I) were transformed into unique divinyl-functionalized polyethylenes (Vin-PE-Vin) by simple treatment with tBuOK in toluene at 95  C. Thiol-ene reactions were then successfully performed on Vin-PE-Vin with functionalized thiols in the presence of AIBN.	Sulfhydryl Compounds	272-278	long intergenic non-protein coding RNA 1191	Homo sapiens	44-47
25688747-2	2015	The iodo-functionalized vinylpolyethylenes (Vin-PE-I) were transformed into unique divinyl-functionalized polyethylenes (Vin-PE-Vin) by simple treatment with tBuOK in toluene at 95  C. Thiol-ene reactions were then successfully performed on Vin-PE-Vin with functionalized thiols in the presence of AIBN.	Sulfhydryl Compounds	272-278	long intergenic non-protein coding RNA 1191	Homo sapiens	121-124
25688747-2	2015	The iodo-functionalized vinylpolyethylenes (Vin-PE-I) were transformed into unique divinyl-functionalized polyethylenes (Vin-PE-Vin) by simple treatment with tBuOK in toluene at 95  C. Thiol-ene reactions were then successfully performed on Vin-PE-Vin with functionalized thiols in the presence of AIBN.	Sulfhydryl Compounds	272-278	long intergenic non-protein coding RNA 1191	Homo sapiens	121-124
25688747-2	2015	The iodo-functionalized vinylpolyethylenes (Vin-PE-I) were transformed into unique divinyl-functionalized polyethylenes (Vin-PE-Vin) by simple treatment with tBuOK in toluene at 95  C. Thiol-ene reactions were then successfully performed on Vin-PE-Vin with functionalized thiols in the presence of AIBN.	Sulfhydryl Compounds	272-278	long intergenic non-protein coding RNA 1191	Homo sapiens	121-124
25688747-2	2015	The iodo-functionalized vinylpolyethylenes (Vin-PE-I) were transformed into unique divinyl-functionalized polyethylenes (Vin-PE-Vin) by simple treatment with tBuOK in toluene at 95  C. Thiol-ene reactions were then successfully performed on Vin-PE-Vin with functionalized thiols in the presence of AIBN.	Sulfhydryl Compounds	272-278	long intergenic non-protein coding RNA 1191	Homo sapiens	121-124
25831516-4	2015	Our biochemical studies showed that auranofin inhibits the bacterial thioredoxin reductase, a protein essential in many Gram-positive bacteria for maintaining the thiol-redox balance and protecting against reactive oxidative species.	Sulfhydryl Compounds	163-168	AT695_RS13830	Staphylococcus aureus	69-90
25605235-1	2015	The cardiac Ca2+ release channel [ryanodine receptor type 2 (RyR2)] is modulated by thiol reactive agents, but the molecular basis of RyR2 modulation by thiol reagents is poorly understood.	Sulfhydryl Compounds	84-89	ryanodine receptor 2	Homo sapiens	34-59
25605235-1	2015	The cardiac Ca2+ release channel [ryanodine receptor type 2 (RyR2)] is modulated by thiol reactive agents, but the molecular basis of RyR2 modulation by thiol reagents is poorly understood.	Sulfhydryl Compounds	84-89	ryanodine receptor 2	Homo sapiens	61-65
25605235-1	2015	The cardiac Ca2+ release channel [ryanodine receptor type 2 (RyR2)] is modulated by thiol reactive agents, but the molecular basis of RyR2 modulation by thiol reagents is poorly understood.	Sulfhydryl Compounds	153-158	ryanodine receptor 2	Homo sapiens	34-59
25605235-1	2015	The cardiac Ca2+ release channel [ryanodine receptor type 2 (RyR2)] is modulated by thiol reactive agents, but the molecular basis of RyR2 modulation by thiol reagents is poorly understood.	Sulfhydryl Compounds	153-158	ryanodine receptor 2	Homo sapiens	61-65
25605235-1	2015	The cardiac Ca2+ release channel [ryanodine receptor type 2 (RyR2)] is modulated by thiol reactive agents, but the molecular basis of RyR2 modulation by thiol reagents is poorly understood.	Sulfhydryl Compounds	153-158	ryanodine receptor 2	Homo sapiens	134-138
25605235-2	2015	Cys3635 in the skeletal muscle RyR1 is one of the most hyper-reactive thiols and is important for the redox and calmodulin (CaM) regulation of the RyR1 channel.	Sulfhydryl Compounds	70-76	ryanodine receptor 1	Homo sapiens	31-35
25605235-2	2015	Cys3635 in the skeletal muscle RyR1 is one of the most hyper-reactive thiols and is important for the redox and calmodulin (CaM) regulation of the RyR1 channel.	Sulfhydryl Compounds	70-76	ryanodine receptor 1	Homo sapiens	147-151
25605235-4	2015	In the present study, we assessed the impact of mutating Cys3602 (C3602A) on store overload-induced Ca2+ release (SOICR) and the regulation of RyR2 by thiol reagents and CaM.	Sulfhydryl Compounds	151-156	ryanodine receptor 2	Homo sapiens	143-147
25605235-9	2015	Therefore, RyR2-Cys3602 is a major site mediating the action of thiol alkylating agent N-ethylmaleimide, but not the action of the oxidant DTDP.	Sulfhydryl Compounds	64-69	ryanodine receptor 2	Homo sapiens	11-15
25645953-8	2015	N-ethylmaleimide, a potent thiol modifier, completely inhibits human glutathione reductase from reducing the mitoNEET [2Fe-2S] clusters, indicating that the redox-active disulfide in the catalytic center of human glutathione reductase may be directly involved in reducing the mitoNEET [2Fe-2S] clusters.	Sulfhydryl Compounds	27-32	CDGSH iron sulfur domain 1	Homo sapiens	109-117
25430046-4	2015	The aim of this study was to evaluate the influence of ABCB1 3435C&gt;T genetic polymorphism on the pharmacokinetics and pharmacodynamics of CLP and its metabolites: diastereoisomers of thiol metabolite (the inactive H3 and the active H4) and inactive carboxylic derivative.	Sulfhydryl Compounds	186-191	ATP binding cassette subfamily B member 1	Homo sapiens	55-60
25705884-3	2015	TRXR and inflammasome activity promoted filopodia formation, cellular release of reduced TRX, and generation of extracellular thiol pathway-dependent, procoagulant microparticles (MPs).	Sulfhydryl Compounds	126-131	thioredoxin	Homo sapiens	0-3
25631887-0	2015	Thiol-disulfide exchange in peptides derived from human growth hormone during lyophilization and storage in the solid state.	Sulfhydryl Compounds	0-5	growth hormone 1	Homo sapiens	56-70
25547066-3	2015	Upon treatment with ONOO(-), this flavonoid also prevented SERCA1 from thiol group oxidation and significantly reduced tyrosine nitration and protein carbonyl formation.	Sulfhydryl Compounds	71-76	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Homo sapiens	59-65
25638402-4	2015	The occurrence of thiol-dependent activities of plant GPX isoenzymes suggests that - besides detoxification of H2O2 and organic hydroperoxides - they may be involved in regulation of the cellular redox homeostasis by maintaining the thiol/disulfide or NADPH/NADP(+) balance.	Sulfhydryl Compounds	233-238	glutathione peroxidase 2	Arabidopsis thaliana	54-57
25793284-3	2015	Each inhibitor contains a pendant side chain thiol that coordinates to the active site Zn(2+) ion, as observed in the X-ray crystal structure of the HDAC8-Largazole complex [Cole, K. E., Dowling, D. P., Boone, M. A., Phillips, A. J., and Christianson, D. W. (2011) J.	Sulfhydryl Compounds	45-50	histone deacetylase 8	Homo sapiens	149-154
25638402-4	2015	The occurrence of thiol-dependent activities of plant GPX isoenzymes suggests that - besides detoxification of H2O2 and organic hydroperoxides - they may be involved in regulation of the cellular redox homeostasis by maintaining the thiol/disulfide or NADPH/NADP(+) balance.	Sulfhydryl Compounds	18-23	glutathione peroxidase 2	Arabidopsis thaliana	54-57
25813625-8	2015	Instead, piperlongumine, which bears electrophilic alpha,beta-unsaturated carbonyl groups, appears to inactivate Kelch-like ECH-associated protein-1 (Keap1) through thiol modification, thereby activating the Nrf2/HO-1 pathway and subsequently upregulating HO-1 expression, which accounts for piperlongumine-induced apoptosis in cancer cells.	Sulfhydryl Compounds	165-170	kelch like ECH associated protein 1	Homo sapiens	113-148
25813625-8	2015	Instead, piperlongumine, which bears electrophilic alpha,beta-unsaturated carbonyl groups, appears to inactivate Kelch-like ECH-associated protein-1 (Keap1) through thiol modification, thereby activating the Nrf2/HO-1 pathway and subsequently upregulating HO-1 expression, which accounts for piperlongumine-induced apoptosis in cancer cells.	Sulfhydryl Compounds	165-170	kelch like ECH associated protein 1	Homo sapiens	150-155
25490055-8	2015	This suggests that PrP(C) requires copper to support the chemical reaction between NO and thiols.	Sulfhydryl Compounds	90-96	prion protein	Homo sapiens	19-25
25196942-0	2015	Thiol-based regulation of glyceraldehyde-3-phosphate dehydrogenase in blood bank-stored red blood cells: a strategy to counteract oxidative stress.	Sulfhydryl Compounds	0-5	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	26-66
25576832-14	2015	Therefore, hTrx1 may provide palmitoylation sites or partially protect the TrxR1 active site selenol/thiol group(s) from palmitoylation.	Sulfhydryl Compounds	101-106	thioredoxin	Homo sapiens	11-16
25576832-14	2015	Therefore, hTrx1 may provide palmitoylation sites or partially protect the TrxR1 active site selenol/thiol group(s) from palmitoylation.	Sulfhydryl Compounds	101-106	thioredoxin reductase 1	Homo sapiens	75-80
32262379-5	2015	The apoferritin modified with CdTe NPs was additionally modified with gold nanoparticles and attached to magnetic particles via oligonucleotide using gold affinity to thiol group.	Sulfhydryl Compounds	167-172	ferritin heavy chain	Equus caballus	4-15
25743024-1	2015	The mode of lysozyme protein adsorption at end-tethered thiol-terminated polyethylene oxide brushes grafted upon gold was determined in situ by neutron reflectivity using the INTER instrument at target station 2, ISIS, RAL, UK.	Sulfhydryl Compounds	56-61	lysozyme	Homo sapiens	12-20
25743024-1	2015	The mode of lysozyme protein adsorption at end-tethered thiol-terminated polyethylene oxide brushes grafted upon gold was determined in situ by neutron reflectivity using the INTER instrument at target station 2, ISIS, RAL, UK.	Sulfhydryl Compounds	56-61	RAS like proto-oncogene A	Homo sapiens	219-222
25196942-2	2015	Accumulating evidence in other cells indicates that oxidative thiol modifications in cytosolic GAPDH drive this molecule into functional avenues that deviate from glycolysis.	Sulfhydryl Compounds	62-67	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	95-100
25561728-1	2015	Thioredoxin (Trx)-fold proteins are protagonists of numerous cellular pathways that are subject to thiol-based redox control.	Sulfhydryl Compounds	99-104	thioredoxin	Homo sapiens	13-16
25561728-2	2015	The best characterized regulator of thiols in proteins is Trx1 itself, which together with thioredoxin reductase 1 (TR1) and peroxiredoxins (Prxs) comprises a key redox regulatory system in mammalian cells.	Sulfhydryl Compounds	36-42	thioredoxin	Homo sapiens	58-62
25561728-2	2015	The best characterized regulator of thiols in proteins is Trx1 itself, which together with thioredoxin reductase 1 (TR1) and peroxiredoxins (Prxs) comprises a key redox regulatory system in mammalian cells.	Sulfhydryl Compounds	36-42	thioredoxin reductase 1	Homo sapiens	116-119
25602117-6	2015	A GC-specific probe was constructed through "click" reaction between the maleimide moiety of PEG ligand and the thiol group from partly reduced antigastric cancer antibody MGb2.	Sulfhydryl Compounds	112-117	secretoglobin family 2A member 1	Homo sapiens	172-176
25516406-5	2015	Anti-EGFR Fab" fragments were conjugated to the surface of nanoparticles via a maleimide-thiol reaction at a high conjugation efficiency and retained specificity following conjugation to the nanoparticles.	Sulfhydryl Compounds	89-94	epidermal growth factor receptor	Homo sapiens	5-9
25717100-6	2015	Targeting mucin disulfide cross-links using current thiol-amino structures such as N-acetylcysteine (NAC) requires high drug concentrations to have mucolytic effects.	Sulfhydryl Compounds	52-57	LOC100508689	Homo sapiens	10-15
25533467-6	2015	Furthermore, the cross-linking of MDR3 with a thiol-reactive fluorophore blocked ATP hydrolysis and exhibited no PC stimulation.	Sulfhydryl Compounds	46-51	ATP binding cassette subfamily B member 4	Homo sapiens	34-38
25699251-7	2015	This led to the hypothesis that Nox2 establishes disulfide bonds with p67 (phox) via a thiol-dilsulfide exchange reaction and, thus, functions as a PDI.	Sulfhydryl Compounds	87-92	cytochrome b-245 beta chain	Homo sapiens	32-36
25573101-1	2015	Thioredoxins (Trx) together with thioredoxin reductases (TrxR) participate in the maintenance of protein thiol homeostasis and play cytoprotective roles in tumor cells.	Sulfhydryl Compounds	105-110	thioredoxin 1	Mus musculus	33-44
25612564-4	2015	Linearity in detector response for total thiols was observed over the range of 1-40 mumol L(-1) for Hcy and glutathione (GSH), 5-100 mumol L(-1) for Cys-Gly, 20-300 mumol L(-1) for Cys and 3.1-37.5 mumol L(-1) (0.2-2.4gL(-1)) for human serum albumin (HSA).	Sulfhydryl Compounds	41-47	albumin	Homo sapiens	236-249
25533469-9	2015	Here we report the results of intermolecular cross-linking of CYP3A4 oligomers with thiol-reactive bifunctional reagents as well as the luminescence resonance energy transfer measurements of interprobe distances in the oligomers of labeled CYP3A4 single-cysteine mutants.	Sulfhydryl Compounds	84-89	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	62-68
25607359-7	2015	Here we report that the unprecedented coupling of two bacterial thiols, MSH and EGT, has a constructive role in the biosynthesis of lincomycin A, a sulfur-containing lincosamide (C8 sugar) antibiotic that has been widely used for half a century to treat Gram-positive bacterial infections.	Sulfhydryl Compounds	64-70	msh homeobox 2	Homo sapiens	72-75
25607359-8	2015	EGT acts as a carrier to template the molecular assembly, and MSH is the sulfur donor for lincomycin maturation after thiol exchange.	Sulfhydryl Compounds	118-123	msh homeobox 2	Homo sapiens	62-65
25607359-9	2015	These thiols function through two unusual S-glycosylations that program lincosamide transfer, activation and modification, providing the first paradigm for EGT-associated biochemical processes and for the poorly understood MSH-dependent biotransformations, a newly described model that is potentially common in the incorporation of sulfur, an element essential for life and ubiquitous in living systems.	Sulfhydryl Compounds	6-12	msh homeobox 2	Homo sapiens	223-226
25552479-0	2015	Tricyclic covalent inhibitors selectively target Jak3 through an active site thiol.	Sulfhydryl Compounds	77-82	Janus kinase 3	Homo sapiens	49-53
25699251-7	2015	This led to the hypothesis that Nox2 establishes disulfide bonds with p67 (phox) via a thiol-dilsulfide exchange reaction and, thus, functions as a PDI.	Sulfhydryl Compounds	87-92	CD33 molecule	Homo sapiens	70-73
25699251-7	2015	This led to the hypothesis that Nox2 establishes disulfide bonds with p67 (phox) via a thiol-dilsulfide exchange reaction and, thus, functions as a PDI.	Sulfhydryl Compounds	87-92	prolyl 4-hydroxylase subunit beta	Homo sapiens	148-151
25289457-0	2015	Redox regulation of Rac1 by thiol oxidation.	Sulfhydryl Compounds	28-33	Rac family small GTPase 1	Homo sapiens	20-24
25264713-5	2015	Basal Prx-2 thiol oxidation increased with RBC age, whereas H2O2-dependent formation of dimeric Prx-2 was similar.	Sulfhydryl Compounds	12-17	peroxiredoxin 2	Homo sapiens	6-11
25289457-9	2015	We also evaluated Rac1(C18S) as a redox-insensitive variant and found that it retains structural and biochemical properties similar to those of Rac1(WT) but is resistant to thiol oxidation.	Sulfhydryl Compounds	173-178	Rac family small GTPase 1	Homo sapiens	18-22
25282040-4	2015	Addition of 1500ppm green tea extract was found to modify MHC as evaluated by SDS-PAGE combining both protein staining and specific thiol staining, indicating that protein modifications generated through reactions of green tea phenolic compounds with protein thiols, disrupted the meat emulsion properties leading to reduced water holding capacity and textural stability.	Sulfhydryl Compounds	132-137	major histocompatibility complex, class I, C	Homo sapiens	58-61
25250537-3	2015	The present study investigates the ability of the thiol-oxidizing agent phenylarsine oxide (PAO) to modulate TRPV1 currents under voltage-clamp conditions.	Sulfhydryl Compounds	50-55	transient receptor potential cation channel subfamily V member 1	Homo sapiens	109-114
25398242-1	2015	Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68(+) KC, play a key role in the induction of hepatic oxidative stress and injuries, we developed a polythiolated- and mannosylated human serum albumin (SH-Man-HSA), which functions as a novel nanoantioxidant for delivering thiol to CD68(+) KC.	Sulfhydryl Compounds	186-191	albumin	Homo sapiens	220-233
25398242-1	2015	Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68(+) KC, play a key role in the induction of hepatic oxidative stress and injuries, we developed a polythiolated- and mannosylated human serum albumin (SH-Man-HSA), which functions as a novel nanoantioxidant for delivering thiol to CD68(+) KC.	Sulfhydryl Compounds	186-191	CD68 molecule	Homo sapiens	315-319
25398242-10	2015	It can be concluded therefore that SH-Man-HSA has great potential for use in a rescue therapy for hepatopathy as a nanoantioxidant because of its ability to efficiently and rapidly deliver thiols to CD68(+)/CD206(+) KC.	Sulfhydryl Compounds	189-195	CD68 molecule	Homo sapiens	199-203
25398242-1	2015	Since reactive oxygen species (ROS) derived from Kupffer cells (KC), especially CD68(+) KC, play a key role in the induction of hepatic oxidative stress and injuries, we developed a polythiolated- and mannosylated human serum albumin (SH-Man-HSA), which functions as a novel nanoantioxidant for delivering thiol to CD68(+) KC.	Sulfhydryl Compounds	186-191	CD68 molecule	Homo sapiens	80-84
25282040-4	2015	Addition of 1500ppm green tea extract was found to modify MHC as evaluated by SDS-PAGE combining both protein staining and specific thiol staining, indicating that protein modifications generated through reactions of green tea phenolic compounds with protein thiols, disrupted the meat emulsion properties leading to reduced water holding capacity and textural stability.	Sulfhydryl Compounds	259-265	major histocompatibility complex, class I, C	Homo sapiens	58-61
25060965-7	2015	Abeta induced a remarkable decrease in total thiol content of hippocampus and borage prevented the decrease of the hippocampal total sulfhydryl (SH) groups.	Sulfhydryl Compounds	45-50	amyloid beta precursor protein	Rattus norvegicus	0-5
24428628-2	2015	In plants, thiol reduction proteins, namely thioredoxin (TRX), glutaredoxin (GRX), and their respective reducers glutathione reductase (GR) and thioredoxin reductase (TR), are organized in complex multigene families.	Sulfhydryl Compounds	11-16	thioredoxin H-type 1	Arabidopsis thaliana	44-55
25468652-3	2015	A change in the codon 118 of the wild-type alpha-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue - GLA p.(Arg118Cys) -, has been recurrently described in large FD screening studies of high-risk patients.	Sulfhydryl Compounds	105-115	galactosidase alpha	Homo sapiens	43-52
25468652-3	2015	A change in the codon 118 of the wild-type alpha-Gal sequence, replacing basic arginine by a potentially sulfhydryl-binding cysteine residue - GLA p.(Arg118Cys) -, has been recurrently described in large FD screening studies of high-risk patients.	Sulfhydryl Compounds	105-115	galactosidase alpha	Homo sapiens	143-146
24428628-2	2015	In plants, thiol reduction proteins, namely thioredoxin (TRX), glutaredoxin (GRX), and their respective reducers glutathione reductase (GR) and thioredoxin reductase (TR), are organized in complex multigene families.	Sulfhydryl Compounds	11-16	thioredoxin H-type 1	Arabidopsis thaliana	57-60
24428628-2	2015	In plants, thiol reduction proteins, namely thioredoxin (TRX), glutaredoxin (GRX), and their respective reducers glutathione reductase (GR) and thioredoxin reductase (TR), are organized in complex multigene families.	Sulfhydryl Compounds	11-16	CAX interacting protein 1	Arabidopsis thaliana	63-75
24428628-2	2015	In plants, thiol reduction proteins, namely thioredoxin (TRX), glutaredoxin (GRX), and their respective reducers glutathione reductase (GR) and thioredoxin reductase (TR), are organized in complex multigene families.	Sulfhydryl Compounds	11-16	CAX interacting protein 1	Arabidopsis thaliana	77-80
24428628-2	2015	In plants, thiol reduction proteins, namely thioredoxin (TRX), glutaredoxin (GRX), and their respective reducers glutathione reductase (GR) and thioredoxin reductase (TR), are organized in complex multigene families.	Sulfhydryl Compounds	11-16	glutathione reductase	Arabidopsis thaliana	113-134
24428628-2	2015	In plants, thiol reduction proteins, namely thioredoxin (TRX), glutaredoxin (GRX), and their respective reducers glutathione reductase (GR) and thioredoxin reductase (TR), are organized in complex multigene families.	Sulfhydryl Compounds	11-16	glutathione reductase	Arabidopsis thaliana	77-79
24428628-2	2015	In plants, thiol reduction proteins, namely thioredoxin (TRX), glutaredoxin (GRX), and their respective reducers glutathione reductase (GR) and thioredoxin reductase (TR), are organized in complex multigene families.	Sulfhydryl Compounds	11-16	thioredoxin H-type 1	Arabidopsis thaliana	144-155
24428628-4	2015	By collecting information from gene expression databases, we have performed a comprehensive in silico study of the expression of all members of different classes of thiol reduction genes (TRX, GRX) in Arabidopsis thaliana.	Sulfhydryl Compounds	165-170	thioredoxin H-type 1	Arabidopsis thaliana	188-191
24428628-4	2015	By collecting information from gene expression databases, we have performed a comprehensive in silico study of the expression of all members of different classes of thiol reduction genes (TRX, GRX) in Arabidopsis thaliana.	Sulfhydryl Compounds	165-170	CAX interacting protein 1	Arabidopsis thaliana	193-196
25541907-1	2015	LTQ Orbitrap MS/MS was used to identify the adducts between quinones derived from rosmarinic acid (RosA) and thiol compounds, including cysteine (Cys), glutathione (GSH), and peptides digested from myosin.	Sulfhydryl Compounds	109-114	myosin heavy chain 14	Homo sapiens	198-204
25308193-4	2015	Structure of the data (MHb and HChr production, and free radical activity of RSH) in Principal Component Analysis visualization and kinetic profiles of chemiluminescence integrate information in terms of the diversity of RSH reaction mechanisms depending on the specific molecular context of the given thiol: aliphatic or aromatic nature as well as the number and position of the -SH groups in the molecule.	Sulfhydryl Compounds	302-307	hemoglobin subunit gamma 2	Homo sapiens	23-26
25584637-6	2015	Differential thiol labeling was used to determine the oxidation states of cysteine residues within p53 after DNA-mediated oxidation.	Sulfhydryl Compounds	13-18	tumor protein p53	Homo sapiens	99-102
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	245-251	iron-sulfur cluster assembly enzyme	Homo sapiens	40-44
25422830-5	2015	Further analysis of tryptic digests of bovine serum albumin (BSA) and alpha-transferrin, showed that increased identification efficiency of the thiol-containing peptides was achieved by combination with IMP or IPP derivatization.	Sulfhydryl Compounds	144-149	transferrin	Homo sapiens	76-87
25422830-6	2015	For example, the identification efficiency of the thiol-containing peptides of alpha-transferrin increased more than 42% upon combination with the IMP or IPP derivatives.	Sulfhydryl Compounds	50-55	transferrin	Homo sapiens	85-96
26064575-4	2015	A mechanism of action consistent with their physiological activity, involving their dissolution in water on contaminated body surfaces, cell membrane penetration and reversible thiolation by a cysteine residue of hTRPA1, supported by data from nuclear magnetic resonance experiments with a model thiol, explains the structure-activity relationships.	Sulfhydryl Compounds	177-182	transient receptor potential cation channel subfamily A member 1	Homo sapiens	213-219
25445832-4	2015	The thiol groups of ThioPASP are able to form disulphide linkages with the mucin glycoproteins and prolong the residence time on the eye.	Sulfhydryl Compounds	4-9	LOC100508689	Homo sapiens	75-80
25597503-0	2015	Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols.	Sulfhydryl Compounds	94-100	frataxin	Homo sapiens	10-18
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	245-251	frataxin	Homo sapiens	46-54
25597503-3	2015	Here we show that frataxin modulates the reactivity of NFS1 persulfide with thiols.	Sulfhydryl Compounds	76-82	frataxin	Homo sapiens	18-26
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	245-251	NFS1 cysteine desulfurase	Homo sapiens	101-105
25597503-3	2015	Here we show that frataxin modulates the reactivity of NFS1 persulfide with thiols.	Sulfhydryl Compounds	76-82	NFS1 cysteine desulfurase	Homo sapiens	55-59
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	245-251	iron-sulfur cluster assembly enzyme	Homo sapiens	137-141
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	245-251	iron-sulfur cluster assembly enzyme	Homo sapiens	137-141
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	319-325	iron-sulfur cluster assembly enzyme	Homo sapiens	40-44
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	319-325	frataxin	Homo sapiens	46-54
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	319-325	NFS1 cysteine desulfurase	Homo sapiens	101-105
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	319-325	iron-sulfur cluster assembly enzyme	Homo sapiens	137-141
25597503-5	2015	Our data reveal that in the presence of ISCU, frataxin enhances the rate of two similar reactions on NFS1 persulfide: sulfur transfer to ISCU leading to the accumulation of a persulfide on the cysteine C104 of ISCU, and sulfur transfer to small thiols such as DTT, L-cysteine and GSH leading to persulfuration of these thiols and ultimately sulfide release.	Sulfhydryl Compounds	319-325	iron-sulfur cluster assembly enzyme	Homo sapiens	137-141
25392302-0	2015	Kinetic control by limiting glutaredoxin amounts enables thiol oxidation in the reducing mitochondrial intermembrane space.	Sulfhydryl Compounds	57-62	glutaredoxin	Homo sapiens	28-40
25534147-1	2015	Treatment of diazo vinyl phosphonate with alcohols, amines, and thiols in the presence of Rh(II) results in the chemo- and stereoselective generation of enol ethers, enamines and vinyl sulfides via an X-H insertion process.	Sulfhydryl Compounds	64-70	Rh blood group D antigen	Homo sapiens	90-96
25575667-9	2015	CONCLUSIONS: Our findings suggest that selective sequestration of PDI1A in a calcium depletion-mediated complex with the abundant chaperone calreticulin attenuates the effective concentration of this major lumenal thiol oxidant, providing a plausible and simple mechanism for the observed shift in ER lumenal redox poise upon physiological calcium depletion.	Sulfhydryl Compounds	214-219	calreticulin	Homo sapiens	140-152
25347386-0	2015	Dynamic asymmetry and the role of the conserved active-site thiol in rabbit muscle creatine kinase.	Sulfhydryl Compounds	60-65	creatine kinase M-type	Oryctolagus cuniculus	76-98
25455449-7	2015	In plasma, cysteine- or N-acetylcysteine-conjugated DPH was detected, and these thiol conjugates levels were correlated with the plasma alanine aminotransferase (ALT) levels.	Sulfhydryl Compounds	80-85	glutamic pyruvic transaminase, soluble	Mus musculus	136-160
25455449-7	2015	In plasma, cysteine- or N-acetylcysteine-conjugated DPH was detected, and these thiol conjugates levels were correlated with the plasma alanine aminotransferase (ALT) levels.	Sulfhydryl Compounds	80-85	glutamic pyruvic transaminase, soluble	Mus musculus	162-165
25462563-11	2015	The concept that emerges is that a thiol-reactive oxidation product of monoHER, formed during oxidative stress, selectively induces the NRF2 pathway and enforces the endogenous antioxidant shield, to provide protection against NAFLD.	Sulfhydryl Compounds	35-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140
25444857-4	2015	Although steady-state studies were first reported for mammalian CDO over 45 years ago, detailed analysis of the specificity for alternative thiol-bearing substrates and their oxidative coupling efficiencies have not been reported for this enzyme.	Sulfhydryl Compounds	140-145	cysteine dioxygenase 1, cytosolic	Mus musculus	64-67
25615965-9	2015	In the structure of Rab3 a modified cysteine residue is observed with an enigmatic electron density attached to its thiol function.	Sulfhydryl Compounds	116-121	Rab3	Drosophila melanogaster	20-26
26210105-1	2015	The CydDC complex of Escherichia coli is a heterodimeric ATP-binding cassette type transporter (ABC transporter) that exports the thiol-containing redox-active molecules cysteine and glutathione.	Sulfhydryl Compounds	130-135	ABC transporter	Escherichia coli	96-111
26210105-5	2015	Given the diverse roles for CydDC in redox homeostasis, respiratory metabolism and the maturation of virulence factors, this ABC transporter is an intriguing system for researchers interested in both the physiology of redox perturbations and the role of low-molecular-weight thiols during infection.	Sulfhydryl Compounds	275-281	ABC transporter	Escherichia coli	125-140
25467515-9	2015	The thiol measurements were used to compare a mutant fly strain with a non-functional cystine-glutamate transporter (xCT) to its background control.	Sulfhydryl Compounds	4-9	solute carrier family 7 member 11	Homo sapiens	117-120
25444857-5	2015	Assuming a similar mechanistic theme among this class of enzymes, characterization of the CDO substrate specificity may provide valuable insight into substrate-active site intermolecular during thiol oxidation.	Sulfhydryl Compounds	194-199	cysteine dioxygenase 1, cytosolic	Mus musculus	90-93
25444857-6	2015	In this work, the substrate-specificity for wild-type Mus musculus CDO was investigated using NMR spectroscopy and LC-MS for a variety of thiol-bearing substrates.	Sulfhydryl Compounds	138-143	cysteine dioxygenase 1, cytosolic	Mus musculus	67-70
25731620-8	2015	In conditions involving down regulated GSH homeostasis, GGC serves as a crucialrate-limiting substrate for GSH synthetase, the main enzyme responsible for condensing glycine with GGC to form the final thiol tripeptide, GSH.	Sulfhydryl Compounds	201-206	gamma-glutamylcyclotransferase	Homo sapiens	56-59
25287889-4	2015	We show that three thiol-reactive small molecules can prevent the tandem-SH2 domains of ZAP-70 and Syk from binding to phosphorylated ITAMs.	Sulfhydryl Compounds	19-24	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	88-94
25287889-4	2015	We show that three thiol-reactive small molecules can prevent the tandem-SH2 domains of ZAP-70 and Syk from binding to phosphorylated ITAMs.	Sulfhydryl Compounds	19-24	spleen associated tyrosine kinase	Homo sapiens	99-102
25807652-0	2015	Elevated oxidative stress monitored via the albumin-thiol redox state is correlated with matrix metalloproteinase-3 elevation in patients with rheumatoid arthritis.	Sulfhydryl Compounds	52-57	matrix metallopeptidase 3	Homo sapiens	89-115
25807652-6	2015	The percentage of oxidized albumin-thiol showed a positive correlation with serum MMP-3 (r = 0.52).	Sulfhydryl Compounds	35-40	matrix metallopeptidase 3	Homo sapiens	82-87
25807652-7	2015	DAS-28 and CRP were also correlated with the percentage of oxidized albumin-thiol (r = 0.46, r = 0.44).	Sulfhydryl Compounds	76-81	C-reactive protein	Homo sapiens	11-14
25807652-8	2015	CONCLUSIONS: The albumin-thiol redox state was significantly oxidized in correlation with serum MMP-3 elevation in RA.	Sulfhydryl Compounds	25-30	matrix metallopeptidase 3	Homo sapiens	96-101
25731620-8	2015	In conditions involving down regulated GSH homeostasis, GGC serves as a crucialrate-limiting substrate for GSH synthetase, the main enzyme responsible for condensing glycine with GGC to form the final thiol tripeptide, GSH.	Sulfhydryl Compounds	201-206	glutathione synthetase	Homo sapiens	107-121
25731620-8	2015	In conditions involving down regulated GSH homeostasis, GGC serves as a crucialrate-limiting substrate for GSH synthetase, the main enzyme responsible for condensing glycine with GGC to form the final thiol tripeptide, GSH.	Sulfhydryl Compounds	201-206	gamma-glutamylcyclotransferase	Homo sapiens	179-182
25265901-5	2015	It is a thiol-independent thioether cleavage and the shedding of PEG chain exclusively happens to PEG-MAL modified conjugates although PEG-vinylsulfone conjugates to thiol-containing proteins also through a C-S linkage.	Sulfhydryl Compounds	166-171	progestagen associated endometrial protein	Homo sapiens	65-68
26527431-1	2015	UNLABELLED: Insulin autoimmune syndrome (IAS) is a rare cause of hyperinsulinemic hypoglycaemia, which is known to occur in association with the use of sulfhydryl-containing drugs and autoimmune disorders.	Sulfhydryl Compounds	152-162	insulin	Homo sapiens	12-19
25561977-6	2015	However, all-thiol form of HMGB1 and delayed but aberrant IL-6 expression characterized chronic inflammation in tumor bearing hosts.	Sulfhydryl Compounds	13-18	high mobility group box 1	Mus musculus	27-32
25479045-0	2015	Expression and distribution of thiol-regulating enzyme glutaredoxin 2 (GRX2) in porcine ocular tissues.	Sulfhydryl Compounds	31-36	glutaredoxin 2 (thioltransferase)	Mus musculus	55-69
25479045-0	2015	Expression and distribution of thiol-regulating enzyme glutaredoxin 2 (GRX2) in porcine ocular tissues.	Sulfhydryl Compounds	31-36	glutaredoxin 2 (thioltransferase)	Mus musculus	71-75
25451646-0	2015	CLL2-1, a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-I (CalDAG-GEFI).	Sulfhydryl Compounds	110-115	RAS guanyl releasing protein 2	Homo sapiens	132-191
25451646-2	2015	Our previous study has shown that CalDAG-GEFI contains redox-sensitive thiols, and its function can be inhibited by thiol modification.	Sulfhydryl Compounds	71-77	RAS guanyl releasing protein 2	Homo sapiens	34-45
25451646-2	2015	Our previous study has shown that CalDAG-GEFI contains redox-sensitive thiols, and its function can be inhibited by thiol modification.	Sulfhydryl Compounds	71-76	RAS guanyl releasing protein 2	Homo sapiens	34-45
25451646-8	2015	Furthermore, the thiol reducing agents also prevented the inhibitory effect of CLL2-1 on Rap1 activation, GPIIb/IIIa activation, and platelet aggregation.	Sulfhydryl Compounds	17-22	RAP1A, member of RAS oncogene family	Homo sapiens	89-93
25451646-8	2015	Furthermore, the thiol reducing agents also prevented the inhibitory effect of CLL2-1 on Rap1 activation, GPIIb/IIIa activation, and platelet aggregation.	Sulfhydryl Compounds	17-22	integrin subunit alpha 2b	Homo sapiens	106-111
25449949-1	2015	Ornithine decarboxylase, the rate limiting enzyme of the polyamine biosynthesis pathway, is significant in the synthesis of trypanothione, T(SH)2, the major reduced thiol which is responsible for the modulation of the immune response and pathogenesis in visceral leishmaniasis.	Sulfhydryl Compounds	165-170	ornithine decarboxylase 1	Homo sapiens	0-23
26236385-4	2015	Mammalian Thioredoxin reductase 1 is an NADPH-dependent selenoprotein, essential for antioxidant defense and DNA synthesis and repair, that regulates the redox system by modulating redox-sensitive transcription factors and thiol-containing proteins.	Sulfhydryl Compounds	223-228	thioredoxin reductase 1	Homo sapiens	10-33
25553376-6	2015	We hypothesize that altered thiol metabolism from heavy metal toxicity, one of the key mechanisms for oxidative stress production, may be responsible for the biochemical alterations in transketolase, dysautonomia and abnormal thiamine homeostasis.	Sulfhydryl Compounds	28-33	transketolase	Homo sapiens	185-198
25673481-3	2015	Here, we present a protocol for the analysis of thiols using muCE-LIF.	Sulfhydryl Compounds	48-54	LIF interleukin 6 family cytokine	Homo sapiens	66-69
25471788-1	2015	The mammalian peroxiredoxin 2 (Prdx2) is a member of thiol-dependent antioxidant proteins and plays an important role in the progression of colorectal cancer (CRC).	Sulfhydryl Compounds	53-58	peroxiredoxin 2	Homo sapiens	14-29
25471788-1	2015	The mammalian peroxiredoxin 2 (Prdx2) is a member of thiol-dependent antioxidant proteins and plays an important role in the progression of colorectal cancer (CRC).	Sulfhydryl Compounds	53-58	peroxiredoxin 2	Homo sapiens	31-36
25725525-1	2015	A cystine-catabolizing enzyme, 3-mercaptopyruvate sulfurtransferase catalyzes the trans-sulfuration reaction of mercaptopyruvate or thiosulfate to thiol-containing compounds or cyanide.	Sulfhydryl Compounds	147-152	mercaptopyruvate sulfurtransferase	Homo sapiens	31-67
25747475-4	2015	Here, we detail in vitro assays for the real-time monitoring of thiol redox states in two model proteins with oxidizable cysteines, PTEN, and roGFP2.	Sulfhydryl Compounds	64-69	phosphatase and tensin homolog	Homo sapiens	132-136
26064419-7	2015	An increase in total antioxidant activity (82%, p &lt;= 0.01) and thiol-disulfide system response (thioredoxin increasing by 33%, p &lt;= 0.01; glutathione, 30%, p &lt;= 0.01 with stable reductases levels) maintains a balance of peroxidation-antioxidant processes, protecting cellular and subcellular structures from significant oxidative damage.	Sulfhydryl Compounds	66-71	thioredoxin	Homo sapiens	99-110
25500537-7	2015	In addition, the oxidative stress-induced decrease in HDAC2 activity was counteracted by S-CMC by increasing thiol/GSH levels, which exhibited a direct interaction with HDAC2.	Sulfhydryl Compounds	109-114	histone deacetylase 2	Homo sapiens	54-59
25500537-0	2015	Carbocysteine restores steroid sensitivity by targeting histone deacetylase 2 in a thiol/GSH-dependent manner.	Sulfhydryl Compounds	83-88	histone deacetylase 2	Homo sapiens	56-77
25500537-7	2015	In addition, the oxidative stress-induced decrease in HDAC2 activity was counteracted by S-CMC by increasing thiol/GSH levels, which exhibited a direct interaction with HDAC2.	Sulfhydryl Compounds	109-114	histone deacetylase 2	Homo sapiens	169-174
25500537-9	2015	Our results indicate that S-CMC restored steroid sensitivity by increasing HDAC2 expression/activity in a thiol/GSH-dependent manner and suggest that S-CMC may be useful in a combination therapy with glucocorticoids for treatment of steroid-insensitive pulmonary diseases.	Sulfhydryl Compounds	106-111	histone deacetylase 2	Homo sapiens	75-80
25037001-2	2015	We designed a thiol-modified hairpin probe where the neck has EcoRI endonuclease recognition sites according to the PRSS1 gene c.410 C&gt;T (p.T137 M) mutation and it was fixed on the gold electrode.	Sulfhydryl Compounds	14-19	serine protease 1	Homo sapiens	116-121
25289458-0	2014	Interaction of adenanthin with glutathione and thiol enzymes: selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling.	Sulfhydryl Compounds	47-52	peroxiredoxin 5	Homo sapiens	78-99
26521879-9	2015	Thiol compounds for irreversibly inhibiting IMP-1 were developed and the binding mode of these inhibitors was investigated in detail.	Sulfhydryl Compounds	0-5	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	44-49
25362663-1	2014	Glutaredoxin 2 (Grx2) is an isozyme of glutaredoxin1 (thioltransferase) present in the mitochondria and nucleus with disulfide reductase and peroxidase activities, and it controls thiol/disulfide balance in cells.	Sulfhydryl Compounds	54-59	glutaredoxin 2 (thioltransferase)	Mus musculus	0-14
25362663-1	2014	Glutaredoxin 2 (Grx2) is an isozyme of glutaredoxin1 (thioltransferase) present in the mitochondria and nucleus with disulfide reductase and peroxidase activities, and it controls thiol/disulfide balance in cells.	Sulfhydryl Compounds	54-59	glutaredoxin 2 (thioltransferase)	Mus musculus	16-20
25362663-1	2014	Glutaredoxin 2 (Grx2) is an isozyme of glutaredoxin1 (thioltransferase) present in the mitochondria and nucleus with disulfide reductase and peroxidase activities, and it controls thiol/disulfide balance in cells.	Sulfhydryl Compounds	54-59	glutaredoxin	Mus musculus	39-52
25451594-8	2014	This hypothesis is supported by the fact that Michael acceptors are the most potent inducers of antioxidant response (as activation of Nrf2 pathway) through generation of mild oxidative stress and that gastroprotective activity of goniothalamin is inhibited after pre-treatment with NEM (N-ethylmaleimide) and NSAID (non-steroidal anti-inflammatory drugs), highlighting the importance of sulfhydryl compounds and prostaglandins on GTN activity.	Sulfhydryl Compounds	388-408	NFE2 like bZIP transcription factor 2	Rattus norvegicus	135-139
25399587-2	2014	Glutaredoxin-1 (Glrx) is a cytosolic enzyme which enzymatically catalyses the reduction in S-glutathionylation, conferring reversible signalling function to proteins with redox-sensitive thiols.	Sulfhydryl Compounds	187-193	glutaredoxin	Mus musculus	0-14
25399587-2	2014	Glutaredoxin-1 (Glrx) is a cytosolic enzyme which enzymatically catalyses the reduction in S-glutathionylation, conferring reversible signalling function to proteins with redox-sensitive thiols.	Sulfhydryl Compounds	187-193	glutaredoxin	Mus musculus	16-20
25545749-0	2014	Evidence for thiol/disulfide exchange reactions between tubulin and glyceraldehyde-3-phosphate dehydrogenase.	Sulfhydryl Compounds	13-18	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	68-108
25545749-5	2014	In thiol/disulfide exchange experiments, tubulin restored ~50% of oxidized GAPDH cysteines and the equilibrium favored reduced GAPDH.	Sulfhydryl Compounds	3-8	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	75-80
25545749-5	2014	In thiol/disulfide exchange experiments, tubulin restored ~50% of oxidized GAPDH cysteines and the equilibrium favored reduced GAPDH.	Sulfhydryl Compounds	3-8	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	127-132
25545749-9	2014	Because the extent of tubulin repair of oxidized GAPDH was dependent on buffer strength, we conclude that electrostatics influence thiol/disulfide exchange between the two proteins.	Sulfhydryl Compounds	131-136	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	49-54
25881428-1	2014	This study was based on the thiol groups (-SH) of PC2~PC6, which could be reacted with the Monobromobimane (mBBr), in order to get polypeptide derivatives with fluorescent signal.	Sulfhydryl Compounds	28-33	keratin 6B	Homo sapiens	50-57
25537203-1	2014	PURPOSE: The purpose of this study was to investigate the thiol repair systems of thioltransferase (TTase) and thioredoxin (Trx) and oxidation-damaged proteins in human cataractous lenses.	Sulfhydryl Compounds	58-63	glutaredoxin	Homo sapiens	82-98
25537203-1	2014	PURPOSE: The purpose of this study was to investigate the thiol repair systems of thioltransferase (TTase) and thioredoxin (Trx) and oxidation-damaged proteins in human cataractous lenses.	Sulfhydryl Compounds	58-63	glutaredoxin	Homo sapiens	100-105
25537203-1	2014	PURPOSE: The purpose of this study was to investigate the thiol repair systems of thioltransferase (TTase) and thioredoxin (Trx) and oxidation-damaged proteins in human cataractous lenses.	Sulfhydryl Compounds	58-63	thioredoxin	Homo sapiens	111-122
25537203-1	2014	PURPOSE: The purpose of this study was to investigate the thiol repair systems of thioltransferase (TTase) and thioredoxin (Trx) and oxidation-damaged proteins in human cataractous lenses.	Sulfhydryl Compounds	58-63	thioredoxin	Homo sapiens	124-127
25453819-6	2014	The most promising compound 9 significantly inhibited (P&lt;0.001) thiol-sensitive sperm hexokinase.	Sulfhydryl Compounds	67-72	hexokinase 1	Homo sapiens	89-99
25460914-4	2014	We have identified HAB1 C186 and C274 as H2O2-sensitive thiols and demonstrate that their oxidation inhibits both HAB1 catalytic activity and its ability to physically associate with SnRK2.6 by formation of intermolecular dimers.	Sulfhydryl Compounds	56-62	HAB1	Homo sapiens	19-23
25135855-7	2014	FAD synthesis is also inhibited by thiol-blocking reagents, suggesting the involvement of free cysteines in the hFADS2 catalytic cycle.	Sulfhydryl Compounds	35-40	fatty acid desaturase 2	Homo sapiens	112-118
32481947-1	2014	Droplet microfluidics is combined with bio-orthogonal thiol-ene click chemistry to fabricate micrometer-sized, monodisperse fibrinogen-containing hyaluronic acid hydrogel microbeads in a mild, radical-free procedure in the presence of human mesenchymal stem cells (hMSCs).	Sulfhydryl Compounds	54-59	fibrinogen beta chain	Homo sapiens	124-134
25231459-6	2014	The wild-type Trx1 contains a conserved C32XXC35 motif, and the C32 thiol initiates the reduction of a target disulfide bond by forming an intermolecular disulfide with one of the oxidized target cysteines, resulting in a transient Trx1-target protein complex.	Sulfhydryl Compounds	68-73	thioredoxin	Homo sapiens	14-18
25231459-6	2014	The wild-type Trx1 contains a conserved C32XXC35 motif, and the C32 thiol initiates the reduction of a target disulfide bond by forming an intermolecular disulfide with one of the oxidized target cysteines, resulting in a transient Trx1-target protein complex.	Sulfhydryl Compounds	68-73	thioredoxin	Homo sapiens	232-236
25231459-7	2014	The reduction is rapidly consummated by the donation of a C35 proton to the target molecule, forming a Trx1 C32-C35 disulfide, and results in the concurrent release of the target protein containing reduced thiols.	Sulfhydryl Compounds	206-212	migration and invasion enhancer 1	Homo sapiens	58-61
25231459-7	2014	The reduction is rapidly consummated by the donation of a C35 proton to the target molecule, forming a Trx1 C32-C35 disulfide, and results in the concurrent release of the target protein containing reduced thiols.	Sulfhydryl Compounds	206-212	thioredoxin	Homo sapiens	103-107
25231459-7	2014	The reduction is rapidly consummated by the donation of a C35 proton to the target molecule, forming a Trx1 C32-C35 disulfide, and results in the concurrent release of the target protein containing reduced thiols.	Sulfhydryl Compounds	206-212	chemokine like factor	Homo sapiens	108-111
25231459-7	2014	The reduction is rapidly consummated by the donation of a C35 proton to the target molecule, forming a Trx1 C32-C35 disulfide, and results in the concurrent release of the target protein containing reduced thiols.	Sulfhydryl Compounds	206-212	migration and invasion enhancer 1	Homo sapiens	112-115
25389312-3	2014	We show activation of hTRPA1 by the thiol oxidant 2-((biotinoyl)amino)ethyl methanethiosulfonate (MTSEA-biotin) and that electrophilic compounds activate hTRPA1 in the presence and absence of the N-terminal ARD.	Sulfhydryl Compounds	36-41	transient receptor potential cation channel subfamily A member 1	Homo sapiens	22-28
25393767-3	2014	After removal of Lyso, followed by a disulfide reduction to cleave the (ethylcarbamoylmethoxy)acetic acid moiety from the MDTA residues, the exposed thiol groups within the imprinted cavities were modified by aminoethylpyridyldisulfide to be transformed into aminoethyl groups that function as active sites for amine-reactive fluorophores.	Sulfhydryl Compounds	149-154	lysozyme	Homo sapiens	17-21
25256748-0	2014	Immobilization of proteins in their physiological active state at functionalized thiol monolayers on ATR-germanium crystals.	Sulfhydryl Compounds	81-86	ATR serine/threonine kinase	Homo sapiens	101-104
25375264-2	2014	Since the presence of sulfur atoms in synthetic N(2)-alkylated nucleotides was reported to be beneficial for sensory activity, a versatile Maillard-type modification of 5"-GMP upon reaction with glycine"s Strecker aldehyde formaldehyde and organic thiols was performed in the present study.	Sulfhydryl Compounds	248-254	5'-nucleotidase, cytosolic II	Homo sapiens	172-175
24328910-4	2014	RECENT ADVANCES: The thioredoxin (Trx) system, which is predominantly expressed in pulmonary epithelia in the newborn lung, acts as an antioxidant system; however, it is increasingly recognized as a key redox regulator of signal transduction and gene expression via thiol-disulfide exchange reactions.	Sulfhydryl Compounds	266-271	thioredoxin	Homo sapiens	21-32
25264847-1	2014	The light-induced and STM-tip-induced switching of photochromic thiol functionalized terphenylthiazole-based diarylethene self-assembly on Au(111) has been investigated in ambient conditions.	Sulfhydryl Compounds	64-69	sulfotransferase family 1A member 3	Homo sapiens	22-25
25227324-2	2014	Simple covalent biofunctionalisation is demonstrated by coupling fibroblast growth factor 2 and an oligosaccharide in a 1 : 1 stoichiometry by thiol-Michael addition.	Sulfhydryl Compounds	143-148	fibroblast growth factor 2	Homo sapiens	65-91
25402564-5	2014	delta-ALA-D inhibition was completely restored by addition of dithiotreitol (DTT) and partly by ZnCl2, demonstrating that the inhibition occurs by oxidation of thiol groups and by displacement of the Zn (II), which can be explained by the presence of chemical elements found in the constitution of pesticides.	Sulfhydryl Compounds	160-165	aminolevulinate dehydratase	Homo sapiens	0-11
24328910-4	2014	RECENT ADVANCES: The thioredoxin (Trx) system, which is predominantly expressed in pulmonary epithelia in the newborn lung, acts as an antioxidant system; however, it is increasingly recognized as a key redox regulator of signal transduction and gene expression via thiol-disulfide exchange reactions.	Sulfhydryl Compounds	266-271	thioredoxin	Homo sapiens	34-37
25014009-3	2014	The degree to which HMGB1 activates a receptor is thought to be dependent upon the oxidative state of the ligand, resulting in the functional isoforms of all-thiol HMGB1 (at-HMGB1) acting through RAGE, and disufide HMGB1 (ds-HMGB1) interacting with TLR4.	Sulfhydryl Compounds	158-163	high mobility group box 1	Homo sapiens	20-25
25443875-3	2014	We hypothesised that thienopyridines expose the free thiol group once acidified (by the stomach) before biotransformation into active metabolites, and in the presence of nitrite (from saliva and the stomach) to form nitrosothiol derivatives (Thienopyridine induced-SNO formation).	Sulfhydryl Compounds	53-58	strawberry notch homolog 1	Homo sapiens	265-268
25014009-3	2014	The degree to which HMGB1 activates a receptor is thought to be dependent upon the oxidative state of the ligand, resulting in the functional isoforms of all-thiol HMGB1 (at-HMGB1) acting through RAGE, and disufide HMGB1 (ds-HMGB1) interacting with TLR4.	Sulfhydryl Compounds	158-163	high mobility group box 1	Homo sapiens	164-169
25014009-3	2014	The degree to which HMGB1 activates a receptor is thought to be dependent upon the oxidative state of the ligand, resulting in the functional isoforms of all-thiol HMGB1 (at-HMGB1) acting through RAGE, and disufide HMGB1 (ds-HMGB1) interacting with TLR4.	Sulfhydryl Compounds	158-163	high mobility group box 1	Homo sapiens	164-169
25014009-3	2014	The degree to which HMGB1 activates a receptor is thought to be dependent upon the oxidative state of the ligand, resulting in the functional isoforms of all-thiol HMGB1 (at-HMGB1) acting through RAGE, and disufide HMGB1 (ds-HMGB1) interacting with TLR4.	Sulfhydryl Compounds	158-163	long intergenic non-protein coding RNA 914	Homo sapiens	196-200
25014009-3	2014	The degree to which HMGB1 activates a receptor is thought to be dependent upon the oxidative state of the ligand, resulting in the functional isoforms of all-thiol HMGB1 (at-HMGB1) acting through RAGE, and disufide HMGB1 (ds-HMGB1) interacting with TLR4.	Sulfhydryl Compounds	158-163	high mobility group box 1	Homo sapiens	164-169
25014009-3	2014	The degree to which HMGB1 activates a receptor is thought to be dependent upon the oxidative state of the ligand, resulting in the functional isoforms of all-thiol HMGB1 (at-HMGB1) acting through RAGE, and disufide HMGB1 (ds-HMGB1) interacting with TLR4.	Sulfhydryl Compounds	158-163	high mobility group box 1	Homo sapiens	164-169
25014009-3	2014	The degree to which HMGB1 activates a receptor is thought to be dependent upon the oxidative state of the ligand, resulting in the functional isoforms of all-thiol HMGB1 (at-HMGB1) acting through RAGE, and disufide HMGB1 (ds-HMGB1) interacting with TLR4.	Sulfhydryl Compounds	158-163	toll like receptor 4	Homo sapiens	249-253
25164014-8	2014	A comparison of antitumor CD8(+) T-cell populations on the basis of surface thiol expression showed that thiol-high cells persisted longer in vivo and exerted superior tumor control.	Sulfhydryl Compounds	105-110	CD8a molecule	Homo sapiens	26-29
25228689-10	2014	These findings suggest that a complex harboring PSA2 and PsaG mediates thiol transactions in the thylakoid lumen that are important for the assembly of PSI.	Sulfhydryl Compounds	71-76	DnaJ/Hsp40 cysteine-rich domain superfamily protein	Arabidopsis thaliana	48-52
25395130-3	2014	As-PC were detected from As(PC2) to As(PC5) with an increasing number of isomers that differ in the position of thiol groups bound to As.	Sulfhydryl Compounds	112-117	proprotein convertase subtilisin/kexin type 5	Homo sapiens	39-42
24288169-7	2014	Pendant peptide, such as integrin ligand RGDS, was more effectively immobilized in the network via a thiol-acrylate reaction (using thiol-bearing peptide Ac-CRGDS.	Sulfhydryl Compounds	101-106	ral guanine nucleotide dissociation stimulator	Homo sapiens	41-45
24288169-7	2014	Pendant peptide, such as integrin ligand RGDS, was more effectively immobilized in the network via a thiol-acrylate reaction (using thiol-bearing peptide Ac-CRGDS.	Sulfhydryl Compounds	132-137	ral guanine nucleotide dissociation stimulator	Homo sapiens	41-45
25205174-1	2014	Self-assembled phospholipid vesicles are functionalized with thrombin-binding aptamers using a thiol-click reaction.	Sulfhydryl Compounds	95-100	coagulation factor II, thrombin	Homo sapiens	61-69
25219599-3	2014	XPS and TGA-MS provide evidence for differing binding modes of the capping thiols.	Sulfhydryl Compounds	75-81	T-box transcription factor 1	Homo sapiens	8-11
25299596-7	2014	Furthermore, we demonstrate that thiol/disulfide exchange in CD4 requires force for exposure of cryptic disulfide bonds.	Sulfhydryl Compounds	33-38	CD4 molecule	Homo sapiens	61-64
32481920-4	2014	Maleimide-conjugated NeutrAvidin (NA), neurotrophin-3 (NT-3) and semaphorin 3A (Sema3A) are then bound to the free thiols, resulting in regions of immobilized guidance cues.	Sulfhydryl Compounds	115-121	neurotrophin 3	Homo sapiens	39-53
24986430-2	2014	S-Nitrosated bovine serum albumin and the S-nitrosated C-terminally truncated form of AdhR-SH (alcohol dehydrogenase regulator) designated as AdhR*-SNO were selectively labelled by the thiosulfonate switch both individually and in protein mixtures containing free thiols.	Sulfhydryl Compounds	264-270	arginine vasopressin receptor 2	Homo sapiens	86-90
24986430-2	2014	S-Nitrosated bovine serum albumin and the S-nitrosated C-terminally truncated form of AdhR-SH (alcohol dehydrogenase regulator) designated as AdhR*-SNO were selectively labelled by the thiosulfonate switch both individually and in protein mixtures containing free thiols.	Sulfhydryl Compounds	264-270	arginine vasopressin receptor 2	Homo sapiens	142-146
24986430-2	2014	S-Nitrosated bovine serum albumin and the S-nitrosated C-terminally truncated form of AdhR-SH (alcohol dehydrogenase regulator) designated as AdhR*-SNO were selectively labelled by the thiosulfonate switch both individually and in protein mixtures containing free thiols.	Sulfhydryl Compounds	264-270	strawberry notch homolog 1	Homo sapiens	148-151
32481920-4	2014	Maleimide-conjugated NeutrAvidin (NA), neurotrophin-3 (NT-3) and semaphorin 3A (Sema3A) are then bound to the free thiols, resulting in regions of immobilized guidance cues.	Sulfhydryl Compounds	115-121	semaphorin 3A	Homo sapiens	65-78
32481920-4	2014	Maleimide-conjugated NeutrAvidin (NA), neurotrophin-3 (NT-3) and semaphorin 3A (Sema3A) are then bound to the free thiols, resulting in regions of immobilized guidance cues.	Sulfhydryl Compounds	115-121	semaphorin 3A	Homo sapiens	80-86
25364233-6	2014	CDDO-Me contains alpha,beta-unsaturated carbonyl groups on rings A and C that can generate reversible adducts with the thiol groups of Cys residues in target proteins such as Keap1 and IkappaB kinase.	Sulfhydryl Compounds	119-124	kelch like ECH associated protein 1	Homo sapiens	175-180
25230918-1	2014	This paper describes the mechanisms of charge recombination on both the nanosecond and microsecond time scales in a donor-acceptor system comprising thiol-modified bis(diarylamino)4,4"-biphenyl (TPD) molecules attached to a CdS quantum dot (QD) via the thiolate linker.	Sulfhydryl Compounds	149-154	CDP-diacylglycerol synthase 1	Homo sapiens	224-227
25243829-2	2014	Xanthine dehydrogenase (XDH), the major form of XOR in tissues, can be converted to xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis.	Sulfhydryl Compounds	122-132	xanthine dehydrogenase	Gallus gallus	0-22
25243829-2	2014	Xanthine dehydrogenase (XDH), the major form of XOR in tissues, can be converted to xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis.	Sulfhydryl Compounds	122-132	xanthine dehydrogenase	Gallus gallus	24-27
25329996-2	2014	Paraoxonase 1 (PON1) is suggested to be a rate-limiting enzyme in the conversion of 2-oxo-clopidogrel to active thiol metabolite with inconsistent results.	Sulfhydryl Compounds	112-117	paraoxonase 1	Homo sapiens	0-13
25329996-2	2014	Paraoxonase 1 (PON1) is suggested to be a rate-limiting enzyme in the conversion of 2-oxo-clopidogrel to active thiol metabolite with inconsistent results.	Sulfhydryl Compounds	112-117	paraoxonase 1	Homo sapiens	15-19
25152419-2	2014	The amino, thiol and carboxylic acid functional groups available on protein coated surface were utilized for covalent immobilization of glucose oxidase and beta-galactosidase, both independently, and in a step-wise manner on the same matrix, with no more than 10% loss of enzyme activity during immobilization.	Sulfhydryl Compounds	11-16	galactosidase beta 1	Homo sapiens	156-174
25112878-5	2014	Of these mutants, pro3 was the most sensitive to tunicamycin and was rescued by anaerobic growth conditions or reduced thiol reagents.	Sulfhydryl Compounds	119-124	pyrroline-5-carboxylate reductase	Saccharomyces cerevisiae S288C	18-22
25106854-4	2014	We have used two-dimensional electrophoresis to demonstrate thiol-dependent self-association of purified recombinant IRP-1 treated with Cd(2+), as well as self-association in Cd(2+)-exposed mesangial cells.	Sulfhydryl Compounds	60-65	aconitase 1	Homo sapiens	117-122
25064478-3	2014	Subsequently, gold nanoparticles (AuNPs) were modified on the electrode to immobilize the thiol-modified thrombin aptamer for fabrication of the thrombin aptasensor.	Sulfhydryl Compounds	90-95	coagulation factor II, thrombin	Homo sapiens	105-113
25064478-3	2014	Subsequently, gold nanoparticles (AuNPs) were modified on the electrode to immobilize the thiol-modified thrombin aptamer for fabrication of the thrombin aptasensor.	Sulfhydryl Compounds	90-95	coagulation factor II, thrombin	Homo sapiens	145-153
24657767-8	2014	Finally, an ester prodrug of the thiol HDAC inhibitor exhibited antiparasitic activity on cultured schistosomes in a dose-dependent manner.	Sulfhydryl Compounds	33-38	histone deacetylase 9	Homo sapiens	39-43
24925443-2	2014	Among the latter is the major thiol reducing thioredoxin system, the activity of which may be diminished by high glucose-induced expression of its endogenous inhibitor, thioredoxin interacting protein (TxnIP).	Sulfhydryl Compounds	30-35	thioredoxin	Homo sapiens	45-56
24925443-2	2014	Among the latter is the major thiol reducing thioredoxin system, the activity of which may be diminished by high glucose-induced expression of its endogenous inhibitor, thioredoxin interacting protein (TxnIP).	Sulfhydryl Compounds	30-35	thioredoxin interacting protein	Homo sapiens	169-200
24925443-2	2014	Among the latter is the major thiol reducing thioredoxin system, the activity of which may be diminished by high glucose-induced expression of its endogenous inhibitor, thioredoxin interacting protein (TxnIP).	Sulfhydryl Compounds	30-35	thioredoxin interacting protein	Homo sapiens	202-207
24925443-14	2014	These findings suggest that impaired thiol reductive capacity, through altered TxnIP expression, contributes to increased ROS in the diabetic heart.	Sulfhydryl Compounds	37-42	thioredoxin interacting protein	Homo sapiens	79-84
24642269-5	2014	First, we will present an overview of the isoform-specific regulation of IP3Rs by cellular factors like IP3, Ca(2+), Ca(2+)-binding proteins, adenosine triphosphate (ATP), thiol modification, phosphorylation and interacting proteins, and of IP3R-isoform specific expression patterns.	Sulfhydryl Compounds	172-177	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	73-77
25078119-14	2014	Importantly, we found by using mutation in key cysteine residues of both p65 and IKK that specific thiol groups are essential for NFkB inhibition by carotenoid derivatives.	Sulfhydryl Compounds	99-104	RELA proto-oncogene, NF-kB subunit	Homo sapiens	73-76
25106706-5	2014	Studies herein indicate that thiol oxidation contributes to cell death through impaired activity of glutathione-dependent and thioredoxin (Trx) systems and altered signaling through redox-sensitive pathways.	Sulfhydryl Compounds	29-34	thioredoxin	Homo sapiens	126-137
25106706-5	2014	Studies herein indicate that thiol oxidation contributes to cell death through impaired activity of glutathione-dependent and thioredoxin (Trx) systems and altered signaling through redox-sensitive pathways.	Sulfhydryl Compounds	29-34	thioredoxin	Homo sapiens	139-142
25078119-16	2014	Pivotal thiol groups of both IKK and p65 play a key role in this process.	Sulfhydryl Compounds	8-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	37-40
25106706-8	2014	However, inhibition of the Trx system yielded the smallest decrease in free thiol content (1.44% with ATG treatment vs 21.33% with BSO treatment).	Sulfhydryl Compounds	76-81	thioredoxin	Homo sapiens	27-30
25265386-2	2014	Thioredoxin-1 (Trx1) is a thiol antioxidant protecting against non-radical oxidants by controlling protein thiol/disulfide status; Trx1 translocates from cytoplasm to cell nuclei due to stress signaling, facilitates DNA binding of transcription factors, e.g., NF-kappaB, and potentiates inflammatory signaling.	Sulfhydryl Compounds	26-31	thioredoxin 1	Mus musculus	0-13
26461315-8	2014	This is desirable for analogic signal transduction and allows the Prx2/Trx/TrxR system to reliably transduce changes in H2O2 supply as changes in thiol oxidation.	Sulfhydryl Compounds	146-151	peroxiredoxin 2	Homo sapiens	66-70
26461315-8	2014	This is desirable for analogic signal transduction and allows the Prx2/Trx/TrxR system to reliably transduce changes in H2O2 supply as changes in thiol oxidation.	Sulfhydryl Compounds	146-151	thioredoxin	Homo sapiens	71-74
25124725-10	2014	In contrast, the activity of BSD2 in preventing the precipitation of reduced beta-chains in vitro in the insulin turbidity assay was thiol-dependent.	Sulfhydryl Compounds	133-138	bundle sheath defective 2	Zea mays	29-33
25124725-11	2014	We conclude that BSD2 combines a chaperone "holdase" function with the ability to interact with free thiols, with both activities being required to protect newly synthesized RbcL chains.	Sulfhydryl Compounds	101-107	bundle sheath defective 2	Zea mays	17-21
25050609-0	2014	High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction.	Sulfhydryl Compounds	84-89	myeloperoxidase	Homo sapiens	60-75
25050609-6	2014	In this retrospective study, we examined whether elevated plasma MPO and SCN(-) levels increased thiol oxidation as a result of increased HOSCN formation, and impacted on long-term survival in 176 subjects (74 non-smokers, 46 smokers, and 56 previous smokers) hospitalized after a first myocardial infarction.	Sulfhydryl Compounds	97-102	myeloperoxidase	Homo sapiens	65-68
25050609-8	2014	However, significant positive correlations were detected between SCN(-) levels and MPO-induced thiol loss in the total population (r = 0.19, P = 0.020) and smokers alone (r = 0.58, P &lt; 0.0001).	Sulfhydryl Compounds	95-100	myeloperoxidase	Homo sapiens	83-86
24838627-7	2014	Moreover, treatment with the thiol group donor N-acetylcysteine completely blocked PRIMA-1-induced apoptosis and reinforced the hypothesis that thiol modifications are important for PRIMA-1 biological activity.	Sulfhydryl Compounds	29-34	proline rich membrane anchor 1	Homo sapiens	83-90
24838627-7	2014	Moreover, treatment with the thiol group donor N-acetylcysteine completely blocked PRIMA-1-induced apoptosis and reinforced the hypothesis that thiol modifications are important for PRIMA-1 biological activity.	Sulfhydryl Compounds	29-34	proline rich membrane anchor 1	Homo sapiens	182-189
24838627-7	2014	Moreover, treatment with the thiol group donor N-acetylcysteine completely blocked PRIMA-1-induced apoptosis and reinforced the hypothesis that thiol modifications are important for PRIMA-1 biological activity.	Sulfhydryl Compounds	144-149	proline rich membrane anchor 1	Homo sapiens	83-90
24838627-7	2014	Moreover, treatment with the thiol group donor N-acetylcysteine completely blocked PRIMA-1-induced apoptosis and reinforced the hypothesis that thiol modifications are important for PRIMA-1 biological activity.	Sulfhydryl Compounds	144-149	proline rich membrane anchor 1	Homo sapiens	182-189
25106424-7	2014	Doxorubicin and doxorubicinol reduced the abundance of thiol groups on RyR2, further indicating that oxidation reactions may be involved in the actions of the compounds.	Sulfhydryl Compounds	55-60	ryanodine receptor 2	Homo sapiens	71-75
25096579-0	2014	Altered thiol chemistry in human amyotrophic lateral sclerosis-linked mutants of superoxide dismutase 1.	Sulfhydryl Compounds	8-13	superoxide dismutase 1	Homo sapiens	81-103
25096579-4	2014	In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation.	Sulfhydryl Compounds	105-110	superoxide dismutase 1	Homo sapiens	9-13
25096579-4	2014	In human SOD1 (hSOD1), a conserved disulfide bond and two free cysteine residues can engage in anomalous thiol/disulfide exchange resulting in non-native disulfides, a hallmark of ALS that is related to protein misfolding and aggregation.	Sulfhydryl Compounds	105-110	superoxide dismutase 1	Homo sapiens	15-20
25265386-2	2014	Thioredoxin-1 (Trx1) is a thiol antioxidant protecting against non-radical oxidants by controlling protein thiol/disulfide status; Trx1 translocates from cytoplasm to cell nuclei due to stress signaling, facilitates DNA binding of transcription factors, e.g., NF-kappaB, and potentiates inflammatory signaling.	Sulfhydryl Compounds	26-31	thioredoxin 1	Mus musculus	15-19
25265386-2	2014	Thioredoxin-1 (Trx1) is a thiol antioxidant protecting against non-radical oxidants by controlling protein thiol/disulfide status; Trx1 translocates from cytoplasm to cell nuclei due to stress signaling, facilitates DNA binding of transcription factors, e.g., NF-kappaB, and potentiates inflammatory signaling.	Sulfhydryl Compounds	107-112	thioredoxin 1	Mus musculus	0-13
25265386-2	2014	Thioredoxin-1 (Trx1) is a thiol antioxidant protecting against non-radical oxidants by controlling protein thiol/disulfide status; Trx1 translocates from cytoplasm to cell nuclei due to stress signaling, facilitates DNA binding of transcription factors, e.g., NF-kappaB, and potentiates inflammatory signaling.	Sulfhydryl Compounds	107-112	thioredoxin 1	Mus musculus	15-19
24983157-6	2014	Based on these properties, we suggest a mechanism for Mia40, where the hydrophobic binding site is employed to select a substrate thiol for forming the initial mixed disulfide.	Sulfhydryl Compounds	130-135	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	54-59
24967549-1	2014	Chemical conjugation of anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs) to organic-inorganic hybrid liposomal immunocerasomes via maleimide-thiol coupling chemistry is explored as a mechanism for selectively targeting cancer cells.	Sulfhydryl Compounds	169-174	epidermal growth factor receptor	Homo sapiens	29-61
25051335-1	2014	A dihydro-TTF derivative with four acetyl-protected thiol ligands was synthesised and adsorbed on Au(111) under UHV conditions.	Sulfhydryl Compounds	52-57	ras homolog family member H	Homo sapiens	10-13
25091325-6	2014	The magnetic nanoparticles coated with specific thiol modified oligonucleotide probe were used successfully in purification of HRG RNA from breast tissue total RNAs with satisfactory yield.	Sulfhydryl Compounds	48-53	histidine rich glycoprotein	Homo sapiens	127-130
24996493-4	2014	The only parameters altered in Gcdh(-/-) compared to wild type (Gcdh(+/+)) mice were a reduction of liver GSH concentrations and of brain sulfhydryl content.	Sulfhydryl Compounds	138-148	glutaryl-Coenzyme A dehydrogenase	Mus musculus	31-35
25036792-2	2014	The redox enzyme thioredoxin reductase (TrxR) plays a vital role in restoring cellular thiol redox balance disrupted by radiation-induced reactive oxygens species (ROS) generation and oxidative damage.	Sulfhydryl Compounds	87-92	peroxiredoxin 5	Homo sapiens	17-38
25036792-2	2014	The redox enzyme thioredoxin reductase (TrxR) plays a vital role in restoring cellular thiol redox balance disrupted by radiation-induced reactive oxygens species (ROS) generation and oxidative damage.	Sulfhydryl Compounds	87-92	peroxiredoxin 5	Homo sapiens	40-44
24967549-1	2014	Chemical conjugation of anti-epidermal growth factor receptor monoclonal antibodies (anti-EGFR mAbs) to organic-inorganic hybrid liposomal immunocerasomes via maleimide-thiol coupling chemistry is explored as a mechanism for selectively targeting cancer cells.	Sulfhydryl Compounds	169-174	epidermal growth factor receptor	Homo sapiens	90-94
24933620-8	2014	Thus, in neurodegenerative states such as PD, maintaining the thiol status of cysteines 296 and 310 in Akt1 would be critical for Akt1 kinase activity and for preventing its degradation by proteasomes.	Sulfhydryl Compounds	62-67	thymoma viral proto-oncogene 1	Mus musculus	103-107
24831724-13	2014	Lower concentrations of reduced thiol groups in COPD patients suggest that a decrease in PON1 activity could reflect oxidative changes of enzyme free cysteine residues.	Sulfhydryl Compounds	32-37	paraoxonase 1	Homo sapiens	89-93
24933620-8	2014	Thus, in neurodegenerative states such as PD, maintaining the thiol status of cysteines 296 and 310 in Akt1 would be critical for Akt1 kinase activity and for preventing its degradation by proteasomes.	Sulfhydryl Compounds	62-67	thymoma viral proto-oncogene 1	Mus musculus	130-134
24632137-6	2014	To this purpose, the transducer surface was functionalized by thiol chemistry and used for recording the binding between Bovine Serum Albumin molecules immobilized onto the surface and its complementary target.	Sulfhydryl Compounds	62-67	albumin	Homo sapiens	128-141
32261671-4	2014	Thiol-induced degradation of the backbone and the assembly of the MRI contrast agent were investigated using GPC and DLS, respectively, and easy degradation was observed.	Sulfhydryl Compounds	0-5	glycophorin C (Gerbich blood group)	Homo sapiens	109-112
25137134-3	2014	In Prx4-mediated oxidative protein folding we discovered a new reaction that the sulfenic acid form of Prx4 can directly react with thiols in folding substrates, resulting in non-native disulfide cross-linking and aggregation.	Sulfhydryl Compounds	132-138	peroxiredoxin 4	Homo sapiens	3-7
25137134-3	2014	In Prx4-mediated oxidative protein folding we discovered a new reaction that the sulfenic acid form of Prx4 can directly react with thiols in folding substrates, resulting in non-native disulfide cross-linking and aggregation.	Sulfhydryl Compounds	132-138	peroxiredoxin 4	Homo sapiens	103-107
24588203-12	2014	CONCLUSIONS: The present study indicated that the majority of the patients with DIP studied showed a pemphigus foliaceus-type phenotype with anti-Dsg1 autoantibodies, caused by thiol-containing drugs.	Sulfhydryl Compounds	177-182	desmoglein 1	Homo sapiens	146-150
24907906-9	2014	Circular dichroism and intrinsic tryptophan fluorescence analysis demonstrated that NstCcmM209 was progressively and irreversibly denatured above 50  C. NstCcmM209 activity was inhibited by the reducing agent tris(hydroxymethyl)phosphine, an effect that was fully reversed by a molar excess of diamide, a thiol oxidizing agent, consistent with oxidative activation being a universal regulatory mechanism of CcmM orthologs.	Sulfhydryl Compounds	305-310	ccmM	Thermosynechococcus elongatus BP-1	87-91
25140450-4	2014	Nuclear factor erythroid-2 related factor 2 (NRF2) is a predominant transcription factor that regulates the expression of a wide array of genes encoding antioxidant proteins, thiol molecules and their generating enzymes, detoxifying enzymes, and stress response proteins, all of which can counteract inflammatory and oxidative damages.	Sulfhydryl Compounds	175-180	NFE2 like bZIP transcription factor 2	Homo sapiens	0-43
25140450-4	2014	Nuclear factor erythroid-2 related factor 2 (NRF2) is a predominant transcription factor that regulates the expression of a wide array of genes encoding antioxidant proteins, thiol molecules and their generating enzymes, detoxifying enzymes, and stress response proteins, all of which can counteract inflammatory and oxidative damages.	Sulfhydryl Compounds	175-180	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
24941337-5	2014	Recently, we reported that decreasing the GSH content in different cell lines induces inhibition of STAT3 activity through the reversible oxidation of thiol groups.	Sulfhydryl Compounds	151-156	signal transducer and activator of transcription 3	Homo sapiens	100-105
24957935-3	2014	Herein, we report on a novel biomimetic approach for an effective assembly of photosystem I with the electron transfer carrier cytochrome c (cyt c), deposited on a thiol-modified gold-surface.	Sulfhydryl Compounds	164-169	cytochrome c, somatic	Homo sapiens	127-139
24957935-3	2014	Herein, we report on a novel biomimetic approach for an effective assembly of photosystem I with the electron transfer carrier cytochrome c (cyt c), deposited on a thiol-modified gold-surface.	Sulfhydryl Compounds	164-169	cytochrome c, somatic	Homo sapiens	141-146
24973725-11	2014	These results suggest that thiol groups of hemoglobin cause splitting of the disulfide bonds of insulin which immediately leads to the formation of new intramolecular disulfide bridges, a reaction which occurs in hemolytic blood and may explain the gradual loss of insulin in postmortem blood samples.	Sulfhydryl Compounds	27-32	insulin	Homo sapiens	96-103
25093837-6	2014	We have determined reactivity trends for a diverse range of thiol nucleophile addition reactions at two separate sites on Aurora-A, and we also highlight limitations when using thiol nucleophiles that contain basic functional groups.	Sulfhydryl Compounds	60-65	aurora kinase A	Homo sapiens	122-130
24686004-1	2014	Direct electrochemistry of cytochrome c (Cyt c) is achieved via Zr(IV) ion as an immobilization matrix to interface Cyt c on gold surface via thiol self-assembled monolayers.	Sulfhydryl Compounds	142-147	cytochrome c, somatic	Homo sapiens	27-39
24686004-1	2014	Direct electrochemistry of cytochrome c (Cyt c) is achieved via Zr(IV) ion as an immobilization matrix to interface Cyt c on gold surface via thiol self-assembled monolayers.	Sulfhydryl Compounds	142-147	cytochrome c, somatic	Homo sapiens	41-46
24686004-1	2014	Direct electrochemistry of cytochrome c (Cyt c) is achieved via Zr(IV) ion as an immobilization matrix to interface Cyt c on gold surface via thiol self-assembled monolayers.	Sulfhydryl Compounds	142-147	cytochrome c, somatic	Homo sapiens	116-121
24619954-0	2014	Rapid on-site separation of As(III) and As(V) in waters using a disposable thiol-modified sand cartridge.	Sulfhydryl Compounds	75-80	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-45
24773038-5	2014	By application of sodium azide, ethylenediaminetetraacetic acid, sodium dodecylsulphate, varying temperature, and spiking endogenous substances we demonstrate that in the case of mammalian sera the assay determines ceruloplasmin (CP) activity with potential interferences from hydroperoxides, iron level, thiols, and albumin.	Sulfhydryl Compounds	305-311	ceruloplasmin	Homo sapiens	215-228
24976139-5	2014	Both major thiol reductive systems, the thioredoxin and the glutathione systems, have been implicated in the reactivation of phosphatases.	Sulfhydryl Compounds	11-16	thioredoxin	Homo sapiens	40-51
24863694-2	2014	The thioredoxin (Trx) and glutaredoxin (Grx) systems are two central systems upholding the sulfhydryl homeostasis by reducing disulfides and mixed disulfides within the cell and thereby protecting against oxidative stress.	Sulfhydryl Compounds	91-101	thioredoxin	Homo sapiens	4-15
24863694-2	2014	The thioredoxin (Trx) and glutaredoxin (Grx) systems are two central systems upholding the sulfhydryl homeostasis by reducing disulfides and mixed disulfides within the cell and thereby protecting against oxidative stress.	Sulfhydryl Compounds	91-101	thioredoxin	Homo sapiens	17-20
24863694-2	2014	The thioredoxin (Trx) and glutaredoxin (Grx) systems are two central systems upholding the sulfhydryl homeostasis by reducing disulfides and mixed disulfides within the cell and thereby protecting against oxidative stress.	Sulfhydryl Compounds	91-101	glutaredoxin	Homo sapiens	26-38
24863694-2	2014	The thioredoxin (Trx) and glutaredoxin (Grx) systems are two central systems upholding the sulfhydryl homeostasis by reducing disulfides and mixed disulfides within the cell and thereby protecting against oxidative stress.	Sulfhydryl Compounds	91-101	glutaredoxin	Homo sapiens	40-43
24973725-11	2014	These results suggest that thiol groups of hemoglobin cause splitting of the disulfide bonds of insulin which immediately leads to the formation of new intramolecular disulfide bridges, a reaction which occurs in hemolytic blood and may explain the gradual loss of insulin in postmortem blood samples.	Sulfhydryl Compounds	27-32	insulin	Homo sapiens	265-272
24850837-3	2014	Thus, we directly assessed the in vivo redox behavior of chloroplast Trx-targeted thiol enzymes in Arabidopsis thaliana.	Sulfhydryl Compounds	82-87	thioredoxin H-type 1	Arabidopsis thaliana	69-72
24214141-5	2014	CYP2C19 PM had decreased Cmax and AUC of thiol metabolite compared with CYP2C19 EM (0.42- and 0.37-fold on day 1, P &lt; .01; 0.39- and 0.34-fold on day 7, P &lt; .01, respectively).	Sulfhydryl Compounds	41-46	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	0-7
24850837-7	2014	These different dependencies of photo-reduction on electron transport, rather than the redox state of Trx and the circadian clock, could readily explain the distinct diurnal redox behaviors of thiol enzymes.	Sulfhydryl Compounds	193-198	thioredoxin H-type 1	Arabidopsis thaliana	102-105
24850837-1	2014	The thiol/disulfide redox network mediated by the thioredoxin (Trx) system in chloroplasts ensures light-responsive control of diverse crucial functions.	Sulfhydryl Compounds	4-9	thioredoxin H-type 1	Arabidopsis thaliana	50-61
24957739-0	2014	2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin.	Sulfhydryl Compounds	36-41	insulin	Homo sapiens	126-133
24850837-1	2014	The thiol/disulfide redox network mediated by the thioredoxin (Trx) system in chloroplasts ensures light-responsive control of diverse crucial functions.	Sulfhydryl Compounds	4-9	thioredoxin H-type 1	Arabidopsis thaliana	63-66
24961813-4	2014	We have discovered that a yeast ubiquitin C-terminal hydrolase (Yuh1) also catalyzes transamidation reactions that can be exploited to prepare site-specifically modified polyubiquitin chains produced by thiol-ene chemistry.	Sulfhydryl Compounds	203-208	ubiquitin	Saccharomyces cerevisiae S288C	32-41
25056878-7	2014	The two channel states were associated with different reactivities of the terminal cysteine of Panx1 to thiol reagents, suggesting different conformations.	Sulfhydryl Compounds	104-109	pannexin 1 L homeolog	Xenopus laevis	95-100
24882429-3	2014	In this study, we provide a computational model of the effect of a prototypical thiol-protected gold nanoparticle, Au25L18(-) (L = S(CH2)2Ph) on the beta2-microglobulin natural fibrillation propensity.	Sulfhydryl Compounds	80-85	beta-2-microglobulin	Homo sapiens	149-168
24961813-4	2014	We have discovered that a yeast ubiquitin C-terminal hydrolase (Yuh1) also catalyzes transamidation reactions that can be exploited to prepare site-specifically modified polyubiquitin chains produced by thiol-ene chemistry.	Sulfhydryl Compounds	203-208	ubiquitin-specific protease YUH1	Saccharomyces cerevisiae S288C	64-68
24920669-9	2014	Taken together, these data indicate that the redox-sensitive Cys-674 thiol on SERCA 2 is required for normal endothelial cell Ca(2+) homeostasis and ischemia-induced angiogenic responses, revealing a novel redox control of angiogenesis via Ca(2+) stores.	Sulfhydryl Compounds	69-74	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	78-85
24359107-1	2014	SIGNIFICANCE: Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme that oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide.	Sulfhydryl Compounds	79-85	quiescin sulfhydryl oxidase 1	Homo sapiens	23-43
24359107-1	2014	SIGNIFICANCE: Quiescin sulfhydryl oxidase 1 (QSOX1) is an enzyme that oxidizes thiols during protein folding, reducing molecular oxygen to hydrogen peroxide.	Sulfhydryl Compounds	79-85	quiescin sulfhydryl oxidase 1	Homo sapiens	45-50
24483600-6	2014	CRITICAL ISSUES: Electron transfer pathways of the oxidative protein folding show conserved Trx-like thiol-disulfide chemistry.	Sulfhydryl Compounds	101-106	thioredoxin	Homo sapiens	92-95
24920669-1	2014	The sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) is key to Ca(2+) homeostasis and is redox-regulated by reversible glutathione (GSH) adducts on the cysteine (C) 674 thiol that stimulate Ca(2+) uptake activity and endothelial cell angiogenic responses in vitro.	Sulfhydryl Compounds	170-175	ATPase, Ca++ transporting, ubiquitous	Mus musculus	4-45
24920669-1	2014	The sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) is key to Ca(2+) homeostasis and is redox-regulated by reversible glutathione (GSH) adducts on the cysteine (C) 674 thiol that stimulate Ca(2+) uptake activity and endothelial cell angiogenic responses in vitro.	Sulfhydryl Compounds	170-175	ATPase, Ca++ transporting, ubiquitous	Mus musculus	47-52
24932680-0	2014	Conjugation of a reactive thiol at the nucleotide binding site for site-specific antibody functionalization.	Sulfhydryl Compounds	26-31	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	39-62
24758166-2	2014	In mammalian cells, the major pathway for de novo disulfide formation involves the enzyme Ero1alpha (endoplasmic reticulum oxidase 1alpha) which couples oxidation of thiols to the reduction of molecular oxygen to form hydrogen peroxide (H2O2).	Sulfhydryl Compounds	166-172	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	90-99
24932680-1	2014	Described here is a UV photo-cross-linking method that utilizes the NBS (nucleotide binding site) for site-specific covalent functionalization of antibodies with reactive thiol moieties (UV-NBS(Thiol)), while preserving antibody activity.	Sulfhydryl Compounds	171-176	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	68-71
24932680-1	2014	Described here is a UV photo-cross-linking method that utilizes the NBS (nucleotide binding site) for site-specific covalent functionalization of antibodies with reactive thiol moieties (UV-NBS(Thiol)), while preserving antibody activity.	Sulfhydryl Compounds	171-176	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	73-96
24932680-1	2014	Described here is a UV photo-cross-linking method that utilizes the NBS (nucleotide binding site) for site-specific covalent functionalization of antibodies with reactive thiol moieties (UV-NBS(Thiol)), while preserving antibody activity.	Sulfhydryl Compounds	194-199	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	68-71
24932680-1	2014	Described here is a UV photo-cross-linking method that utilizes the NBS (nucleotide binding site) for site-specific covalent functionalization of antibodies with reactive thiol moieties (UV-NBS(Thiol)), while preserving antibody activity.	Sulfhydryl Compounds	194-199	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	73-96
24932680-2	2014	By synthesizing an indole-3-butyric acid (IBA) conjugated version of cysteine we site-specifically photo-cross-linked a reactive thiol moiety to antibodies at the NBS.	Sulfhydryl Compounds	129-134	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	163-166
24932680-4	2014	Our results demonstrate the utility of the UV-NBS(Thiol) method by successfully functionalizing a prostate specific antigen antibody (IgG(PSA)) with IBA-Thiol and subsequent reaction with maleimide-fluorescein.	Sulfhydryl Compounds	50-55	kallikrein related peptidase 3	Homo sapiens	98-123
24932680-6	2014	Utilizing the IBA-Thiol ligand allows for an efficient means of site-specifically conjugating UV sensitive functionalities to antibody NBS that would otherwise not have been amenable by the previously described UV-NBS photo-cross-linking method.	Sulfhydryl Compounds	18-23	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	135-138
24932680-6	2014	Utilizing the IBA-Thiol ligand allows for an efficient means of site-specifically conjugating UV sensitive functionalities to antibody NBS that would otherwise not have been amenable by the previously described UV-NBS photo-cross-linking method.	Sulfhydryl Compounds	18-23	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	214-217
24727215-1	2014	The major thiol-containing molecules involved in controlling the level of intracellular ROS in eukaryotes, acting as a nonenzymatic detoxification system, are metallothioneins (MTs), glutathione (GSH) and phytochelatins (PCs).	Sulfhydryl Compounds	10-15	Glutathione gamma-glutamylcysteinyltransferase	Caenorhabditis elegans	221-224
24802369-3	2014	Experimentally we investigated the hybridization effect (hybridization efficiency H(E) and hybridization density H(D)) of thiol-modified probe DNA (DNA base amount m = 15, 25 or 35)/mercaptohexanol (MCH) mixed SAMs on gold in 1 M electrolyte solution by chronocoulometry (CC) and electrochemical impedance spectroscopy (EIS).	Sulfhydryl Compounds	122-127	pro-melanin concentrating hormone	Homo sapiens	199-202
24631867-2	2014	Their biosynthesis relies on a complex post-translational process, called cytochrome c biogenesis, responsible for the formation of stereo-specific thioether bonds between the vinyl groups of heme b (protoporphyrin IX-Fe) and the thiol groups of apocytochromes c heme-binding site (C1XXC2H) cysteine residues.	Sulfhydryl Compounds	230-235	cytochrome c, somatic	Homo sapiens	74-86
24746228-5	2014	Thiol modified glycans were covalently bound to a model protein carrier, maleimide functionalized bovine serum albumin (BSA), and the number of glycans per BSA modulated.	Sulfhydryl Compounds	0-5	albumin	Homo sapiens	105-118
24832501-0	2014	Thiol-PEG-carboxyl-stabilized Fe2O 3/Au nanoparticles targeted to CD105: synthesis, characterization and application in MR imaging of tumor angiogenesis.	Sulfhydryl Compounds	0-5	endoglin	Mus musculus	66-71
24832501-1	2014	OBJECTIVE: To detect tumor angiogenesis in tumor-bearing mice using thiol-PEG-carboxyl-stabilized Fe2O3/Au nanoparticles targeted to CD105 on magnetic resonance imaging (MRI).	Sulfhydryl Compounds	68-73	endoglin	Mus musculus	133-138
24832501-13	2014	CONCLUSION: Anti-CD105 antibody-coupled, thiol-PEG-carboxyl-stabilized core-shell Fe2O3/Au nanoparticles can efficiently target CD105 expressed by HUVECs.	Sulfhydryl Compounds	41-46	endoglin	Mus musculus	17-22
24832501-13	2014	CONCLUSION: Anti-CD105 antibody-coupled, thiol-PEG-carboxyl-stabilized core-shell Fe2O3/Au nanoparticles can efficiently target CD105 expressed by HUVECs.	Sulfhydryl Compounds	41-46	endoglin	Mus musculus	128-133
24902036-1	2014	Site-directed spin labeling of the unnatural amino acid p-acetylphenylalanine (p-AcPhe) using oxime based coupling chemistry is successfully applied to investigate human sulfite oxidase (hSO), a protein containing an essential cysteine residue, which impedes the use of thiol based coupling chemistry.	Sulfhydryl Compounds	270-275	sulfite oxidase	Homo sapiens	170-185
24806338-2	2014	It enabled not only thiol-induced cleavage of the linker for enrichment of the target protein but also selective labelling to pick out the target from contaminated non-target proteins for facile identification.	Sulfhydryl Compounds	20-25	protein interacting with PRKCA 1	Homo sapiens	126-130
24838693-7	2014	Importantly, our strategy was fully compatible with the presence of protein thiol groups, as demonstrated by the synthesis of peptides modified by the human small ubiquitin-related modifier 3 protein.	Sulfhydryl Compounds	76-81	small ubiquitin like modifier 3	Homo sapiens	157-191
24940866-2	2014	The His-tagged VC1 domains of Receptors for Advanced Glycation End (RAGE) products used as analytically active molecules were covalently immobilized on a monolayer of a thiol derivative of pentetic acid (DPTA) complex with Cu(II) deposited on a gold electrode surface.	Sulfhydryl Compounds	169-174	long intergenic non-protein coding RNA 914	Homo sapiens	30-66
24678915-1	2014	The glucose stimulation of insulin secretion by pancreatic beta-cells depends on increased production of metabolic coupling factors, among which changes in NADPH and ROS (reactive oxygen species) may alter the glutathione redox state (EGSH) and signal through changes in thiol oxidation.	Sulfhydryl Compounds	271-276	insulin	Homo sapiens	27-34
24940866-2	2014	The His-tagged VC1 domains of Receptors for Advanced Glycation End (RAGE) products used as analytically active molecules were covalently immobilized on a monolayer of a thiol derivative of pentetic acid (DPTA) complex with Cu(II) deposited on a gold electrode surface.	Sulfhydryl Compounds	169-174	long intergenic non-protein coding RNA 914	Homo sapiens	68-72
24805286-6	2014	In cell-culture systems, in addition to significant phototoxicity and intracellular uptake, we observed that the dequenching processes of PhA in the mPEG-(ss-PhA)2 NPs highly depended on the expression of intracellular thiols and that supplementation with glutathione monoethylester facilitated more rapid PhA release and enhanced the PhA phototoxicity.	Sulfhydryl Compounds	219-225	lamin B receptor	Homo sapiens	138-141
24840911-6	2014	Control experiments serve to confirm that the response seen for the present probe is due to Trx and that it is selective over various potentially competing metabolites, including thiol-containing small molecules and test proteins.	Sulfhydryl Compounds	179-184	thioredoxin	Homo sapiens	92-95
24729298-2	2014	Herein we describe a dinuclear gold(I) complex (1-PF6) utilizing a bridging bis(N-heterocyclic carbene) ligand to attain thiol stability and a diphosphine ligand to keep appropriate thiol reactivity.	Sulfhydryl Compounds	182-187	sperm associated antigen 17	Mus musculus	50-53
24729298-3	2014	Complex 1-PF6 displays a favorable stability that allows it to inhibit TrxR activity without being attacked by blood thiols.	Sulfhydryl Compounds	117-123	sperm associated antigen 17	Mus musculus	10-13
24729298-1	2014	In the design of anticancer gold(I) complexes with high in vivo efficacy, tuning the thiol reactivity to achieve stability towards blood thiols yet maintaining the thiol reactivity to target cellular thioredoxin reductase (TrxR) is of pivotal importance.	Sulfhydryl Compounds	85-90	peroxiredoxin 2	Mus musculus	223-227
24754567-2	2014	EGFR-targeting aptamers were conjugated to HAuNS (apt-HAuNS) by attaching a thiol-terminated single-stranded DNA to the HAuNS and then adding the complementary RNA targeted to EGFR.	Sulfhydryl Compounds	76-81	epidermal growth factor receptor	Homo sapiens	0-4
24729298-2	2014	Herein we describe a dinuclear gold(I) complex (1-PF6) utilizing a bridging bis(N-heterocyclic carbene) ligand to attain thiol stability and a diphosphine ligand to keep appropriate thiol reactivity.	Sulfhydryl Compounds	121-126	sperm associated antigen 17	Mus musculus	50-53
24699624-4	2014	Mechanistic investigations revealed that AS101 caused redox inactivation of adjacent thiols in the exofacial domain of VLA-4 after its ligation to stromal fibronectin.	Sulfhydryl Compounds	85-91	fibronectin 1	Homo sapiens	155-166
24598312-5	2014	However, the thiol in Cys-VL85 neighboring Cys-VL84 in the CDR3 of the light chain is likely to mismatch with the thiol in Cys-VL16 during the renaturing process.	Sulfhydryl Compounds	13-18	CDR3	Homo sapiens	59-63
24598312-5	2014	However, the thiol in Cys-VL85 neighboring Cys-VL84 in the CDR3 of the light chain is likely to mismatch with the thiol in Cys-VL16 during the renaturing process.	Sulfhydryl Compounds	114-119	CDR3	Homo sapiens	59-63
24744239-4	2014	In addition, thiol crosslinking of Mus81-Mms4 bound to DNA junctions demonstrates that the heterodimer undergoes a conformational change induced by joint DNA molecules with preferred structural properties.	Sulfhydryl Compounds	13-18	Mus81p	Saccharomyces cerevisiae S288C	35-40
24744239-4	2014	In addition, thiol crosslinking of Mus81-Mms4 bound to DNA junctions demonstrates that the heterodimer undergoes a conformational change induced by joint DNA molecules with preferred structural properties.	Sulfhydryl Compounds	13-18	Mms4p	Saccharomyces cerevisiae S288C	41-45
24934525-10	2014	Disulfide-thiol exchange mediated by PDI appears to be involved in the conformational changes in integrin activation.	Sulfhydryl Compounds	10-15	prolyl 4-hydroxylase subunit beta	Homo sapiens	37-40
24516001-3	2014	Thioredoxin reductases (TrxR) and glutathione peroxidases (GPx) are selenoenzymes that constitute part of the major thiol-dependent antioxidant systems in cells.	Sulfhydryl Compounds	116-121	thioredoxin 1	Mus musculus	0-11
24516001-3	2014	Thioredoxin reductases (TrxR) and glutathione peroxidases (GPx) are selenoenzymes that constitute part of the major thiol-dependent antioxidant systems in cells.	Sulfhydryl Compounds	116-121	glutathione peroxidase 4	Mus musculus	59-62
24661219-10	2014	This is supported by our findings that alkylation of reduced TrxR with biotin-conjugated iodoacetamide, which selectively reacts with selenol or thiol groups on proteins, was inhibited by NAPQI.	Sulfhydryl Compounds	145-150	peroxiredoxin 5	Homo sapiens	61-65
24716714-9	2014	These findings emphasize the importance of respiratory substrates in regulating S-nitrosylation through a thiol-dependent (GSH and/or thioredoxin) pathway, with implications for mitochondrial bioenergetics and mitochondrion-driven apoptosis.	Sulfhydryl Compounds	106-111	thioredoxin 1	Rattus norvegicus	134-145
23833801-0	2010	ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE) Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that is strongly implicated in the pathogenesis of multiple highly prevalent diseases, including type 2 diabetes and Alzheimer"s disease (AD).	Sulfhydryl Compounds	108-113	insulin degrading enzyme	Homo sapiens	41-65
23833801-0	2010	ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE) Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that is strongly implicated in the pathogenesis of multiple highly prevalent diseases, including type 2 diabetes and Alzheimer"s disease (AD).	Sulfhydryl Compounds	108-113	insulin degrading enzyme	Homo sapiens	67-70
23833801-0	2010	ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE) Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that is strongly implicated in the pathogenesis of multiple highly prevalent diseases, including type 2 diabetes and Alzheimer"s disease (AD).	Sulfhydryl Compounds	108-113	insulin degrading enzyme	Homo sapiens	72-96
23833801-0	2010	ML345, A Small-Molecule Inhibitor of the Insulin-Degrading Enzyme (IDE) Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that is strongly implicated in the pathogenesis of multiple highly prevalent diseases, including type 2 diabetes and Alzheimer"s disease (AD).	Sulfhydryl Compounds	108-113	insulin degrading enzyme	Homo sapiens	98-101
24352565-7	2014	In addition, CalDAG-GEFI formed disulfide-linked oligomers in platelets treated with the thiol-oxidant diamide, indicating that CalDAG-GEFI contains redox-sensitive thiols.	Sulfhydryl Compounds	165-171	RAS guanyl releasing protein 2	Homo sapiens	13-24
24778250-7	2014	The oxidoreductase activities of TRP14 thereby complement those of Trx1 and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols.	Sulfhydryl Compounds	165-171	thioredoxin domain containing 17	Homo sapiens	33-38
24778250-7	2014	The oxidoreductase activities of TRP14 thereby complement those of Trx1 and must therefore be considered for the full understanding of enzymatic control of cellular thiols and nitrosothiols.	Sulfhydryl Compounds	165-171	thioredoxin	Homo sapiens	67-71
24352565-7	2014	In addition, CalDAG-GEFI formed disulfide-linked oligomers in platelets treated with the thiol-oxidant diamide, indicating that CalDAG-GEFI contains redox-sensitive thiols.	Sulfhydryl Compounds	165-171	RAS guanyl releasing protein 2	Homo sapiens	128-139
24733836-4	2014	Here we use cysteine scanning mutagenesis, thiol-reactive reagents, and patch-clamp analysis to define the residues that assist in formation of the 2-APB-activated Orai3 pore.	Sulfhydryl Compounds	43-48	arginyl aminopeptidase	Homo sapiens	150-153
24440420-3	2014	PEG-PAA-PDEA (1.9-0.8-8.2kgmol(-1)) was synthesized by controlled reversible addition-fragmentation chain transfer polymerization and further modified with cysteamine to yield the thiol-containing PEG-PAA(SH)-PDEA copolymer.	Sulfhydryl Compounds	180-185	phosphodiesterase 6A	Homo sapiens	8-12
24440420-3	2014	PEG-PAA-PDEA (1.9-0.8-8.2kgmol(-1)) was synthesized by controlled reversible addition-fragmentation chain transfer polymerization and further modified with cysteamine to yield the thiol-containing PEG-PAA(SH)-PDEA copolymer.	Sulfhydryl Compounds	180-185	phosphodiesterase 6A	Homo sapiens	209-213
24944912-1	2014	Glutaredoxin 2 is a vertebrate specific oxidoreductase of the thioredoxin family of proteins modulating the intracellular thiol pool.	Sulfhydryl Compounds	122-127	glutaredoxin 2	Danio rerio	0-14
24944912-2	2014	Thereby, glutaredoxin 2 is important for specific redox signaling and regulates embryonic development of brain and vasculature via reversible oxidative posttranslational thiol modifications.	Sulfhydryl Compounds	170-175	glutaredoxin 2	Danio rerio	9-23
24641901-8	2014	Kidneys from naive Mrp2-null mice had elevated glutathione S-transferase mRNA levels, which could increase the formation of cisplatin-glutathione conjugates that may be metabolized to toxic thiol intermediates.	Sulfhydryl Compounds	190-195	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	19-23
24641901-8	2014	Kidneys from naive Mrp2-null mice had elevated glutathione S-transferase mRNA levels, which could increase the formation of cisplatin-glutathione conjugates that may be metabolized to toxic thiol intermediates.	Sulfhydryl Compounds	190-195	hematopoietic prostaglandin D synthase	Mus musculus	47-72
24500895-1	2014	High-performance liquid chromatography-fluorescence detection using a hydrophilic interaction chromatography-mode column (ZIC -HILIC) was used to determine four kinds of thiol compounds in human serum.	Sulfhydryl Compounds	170-175	Zic family member 1	Homo sapiens	122-125
24512908-7	2014	Thiol modification of the cysteine residue in the p65 RHD region was required for the CO-modulated NF-kappaB activation.	Sulfhydryl Compounds	0-5	RELA proto-oncogene, NF-kB subunit	Homo sapiens	50-53
24733836-4	2014	Here we use cysteine scanning mutagenesis, thiol-reactive reagents, and patch-clamp analysis to define the residues that assist in formation of the 2-APB-activated Orai3 pore.	Sulfhydryl Compounds	43-48	ORAI calcium release-activated calcium modulator 3	Homo sapiens	164-169
24680828-5	2014	Furthermore, OGG1 complex formation was inhibited by incubation of cells with the thiol reducing agents beta-mercaptoethanol and dithiothreitol and the antioxidant dimethylsulfoxide indicating a causative role for oxidative stress in the formation of OGG1 cellular complexes.	Sulfhydryl Compounds	82-87	8-oxoguanine DNA glycosylase	Homo sapiens	13-17
23836328-2	2014	Glutaredoxin 1(Grx1) is a cytosolic redox protein that catalyzes GSH-dependent thiol redox reactions and reversible protein S-glutathionylation.	Sulfhydryl Compounds	79-84	glutaredoxin	Homo sapiens	0-14
24646287-2	2014	In this approach, CdS nanocrystals (NCs) were first coated on glassy carbon electrode, and then thiol-modified telomerase primer was attached on CdS NCs via Cd-S bond.	Sulfhydryl Compounds	96-101	CDP-diacylglycerol synthase 1	Homo sapiens	157-161
24649965-4	2014	When a Pt nanoparticle is attached to the molecular wire by reductive cleavage of the disulfide and reaction with the resulting thiol, the PS I-NQ(CH2)15S-Pt nanoconstruct evolves dihydrogen at a rate of 67.3 mumol of H2 (mg of Chl)(-1) h(-1) [3.4 e(-) (PS I)(-1) s(-1)] after illumination for 1 h at pH 6.4.	Sulfhydryl Compounds	128-133	chordin like 1	Homo sapiens	228-231
24550391-6	2014	Furthermore, NaHS decreased the ratio of free thiol groups in p65, whereas the thiol reductant DTT reversed the inhibiting effect of H2S on the p65 DNA binding activity.	Sulfhydryl Compounds	79-84	RELA proto-oncogene, NF-kB subunit	Homo sapiens	144-147
24550391-9	2014	The sulfhydration of free thiol group on cysteine 38 in p65 served as a molecular mechanism by which H2S inhibited NF-kappaB pathway activation in ox-LDL-induced macrophage inflammation.	Sulfhydryl Compounds	26-31	RELA proto-oncogene, NF-kB subunit	Homo sapiens	56-59
24550391-9	2014	The sulfhydration of free thiol group on cysteine 38 in p65 served as a molecular mechanism by which H2S inhibited NF-kappaB pathway activation in ox-LDL-induced macrophage inflammation.	Sulfhydryl Compounds	26-31	nuclear factor kappa B subunit 1	Homo sapiens	115-124
24699133-1	2014	The human erythrocyte contains an abundance of the thiol-dependant peroxidase Peroxiredoxin-2 (Prx2), which protects the cell from the pro-oxidant environment it encounters during its 120 days of life in the blood stream.	Sulfhydryl Compounds	51-56	peroxiredoxin 2	Homo sapiens	78-93
24699133-1	2014	The human erythrocyte contains an abundance of the thiol-dependant peroxidase Peroxiredoxin-2 (Prx2), which protects the cell from the pro-oxidant environment it encounters during its 120 days of life in the blood stream.	Sulfhydryl Compounds	51-56	peroxiredoxin 2	Homo sapiens	95-99
24577225-0	2014	N-Heterocyclic carbene-catalyzed formal cross-coupling reaction of alpha-haloenals with thiols: organocatalytic construction of sp2 carbon-sulfur bonds.	Sulfhydryl Compounds	88-94	Sp2 transcription factor	Homo sapiens	128-131
23836328-2	2014	Glutaredoxin 1(Grx1) is a cytosolic redox protein that catalyzes GSH-dependent thiol redox reactions and reversible protein S-glutathionylation.	Sulfhydryl Compounds	79-84	glutaredoxin	Homo sapiens	15-19
24333987-2	2014	Known thiol reactive compounds including phenylarsine oxide and nitroxyl are the fastest acting stimulators of glucose uptake, implicating cysteine biochemistry as critical to the acute activation of GLUT1.	Sulfhydryl Compounds	6-11	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	200-205
24412704-8	2014	These two thiol compounds also partially suppressed oxidative frameshift mutations in the coding microsatellites of the hMSH6 and CHK1 genes based on a fluoresceinated PCR-based assay.	Sulfhydryl Compounds	10-15	mutS homolog 6	Homo sapiens	120-125
24482111-4	2014	The proposed method was significantly sensitive compared to those using electrochemical or even LIF detection in MCE-based setup reported previously, and applied to the determination of intracellular thiols in macrophage RAW264.7 cells.	Sulfhydryl Compounds	200-206	leukemia inhibitory factor	Mus musculus	96-99
24412704-8	2014	These two thiol compounds also partially suppressed oxidative frameshift mutations in the coding microsatellites of the hMSH6 and CHK1 genes based on a fluoresceinated PCR-based assay.	Sulfhydryl Compounds	10-15	checkpoint kinase 1	Homo sapiens	130-134
24549831-0	2014	Thiol-disulfide exchange in peptides derived from human growth hormone.	Sulfhydryl Compounds	0-5	growth hormone 1	Homo sapiens	56-70
24486553-5	2014	Both L- and D-CysNO also inhibited cellular pyruvate uptake and caused S-nitrosation of thiol groups on monocarboxylate transporter 1, a proton-linked pyruvate transporter.	Sulfhydryl Compounds	88-93	solute carrier family 16 member 1	Homo sapiens	104-133
24468475-7	2014	However, the ability of QSOX1 to rapidly oxidize conformationally mobile protein thiols suggests a possible contribution to the redox status of exofacial and soluble proteins in blood plasma.	Sulfhydryl Compounds	81-87	quiescin sulfhydryl oxidase 1	Bos taurus	24-29
24549831-4	2014	Here, we present experimental data for the mechanism of thiol-disulfide exchange in tryptic peptides derived from human growth hormone in aqueous solution.	Sulfhydryl Compounds	56-61	growth hormone 1	Homo sapiens	120-134
24675966-4	2014	Extracellular (EC) fragments of E-cadherin fused to the SNAP-tag were covalently bound to self-assembled monolayers (SAM) of thiols carrying benzylguanine (BG) head groups.	Sulfhydryl Compounds	125-131	cadherin 1	Homo sapiens	32-42
24452853-5	2014	This article will review some of the still controversial mechanisms implicated in cellular TF activation or decryption with particular focus on the coordinated effects of outer leaflet phosphatidylserine exposure and thiol-disulfide exchange pathways involving protein disulfide isomerase (PDI).	Sulfhydryl Compounds	217-222	coagulation factor III, tissue factor	Homo sapiens	91-93
24452853-5	2014	This article will review some of the still controversial mechanisms implicated in cellular TF activation or decryption with particular focus on the coordinated effects of outer leaflet phosphatidylserine exposure and thiol-disulfide exchange pathways involving protein disulfide isomerase (PDI).	Sulfhydryl Compounds	217-222	prolyl 4-hydroxylase subunit beta	Homo sapiens	261-288
24201004-3	2014	Thiol-labeled long chain hydrocarbon with bisphenol A (BPA) as head group was synthesized and self-assembled on the Au nanoparticle surface as the sensing probes, which showed a linear response upon the binding of estrogen receptor (ER-alpha) ranging from 1 to 30 nM.	Sulfhydryl Compounds	0-5	estrogen receptor 1	Homo sapiens	214-231
24469450-13	2014	Thus, ROS seem to specifically sensitize IP3Rs through a thiol group(s) within the IP3R, which is probably inaccessible in the chicken IP3R3.	Sulfhydryl Compounds	57-62	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	135-140
24482798-8	2014	SPR analysis was done by injecting HepG2 and HuH7 cell suspensions (2-4 x 10(4) cells per mL) onto a sensor surface previously immobilized with VEGF via a thiol self-assembled monolayer (SAM).	Sulfhydryl Compounds	155-160	vascular endothelial growth factor A	Homo sapiens	144-148
24201004-3	2014	Thiol-labeled long chain hydrocarbon with bisphenol A (BPA) as head group was synthesized and self-assembled on the Au nanoparticle surface as the sensing probes, which showed a linear response upon the binding of estrogen receptor (ER-alpha) ranging from 1 to 30 nM.	Sulfhydryl Compounds	0-5	estrogen receptor 1	Homo sapiens	233-241
24451382-10	2014	These results indicate that glutathione adducts on specific SirT1 thiols may be responsible for dysfunctional SirT1 associated with liver disease in metabolic syndrome.	Sulfhydryl Compounds	66-72	sirtuin 1	Homo sapiens	60-65
24451382-10	2014	These results indicate that glutathione adducts on specific SirT1 thiols may be responsible for dysfunctional SirT1 associated with liver disease in metabolic syndrome.	Sulfhydryl Compounds	66-72	sirtuin 1	Homo sapiens	110-115
24445170-0	2014	A thiol functionalized cryogel as a solid phase for selective reduction of a cysteine residue in a recombinant human growth hormone variant.	Sulfhydryl Compounds	2-7	growth hormone 1	Homo sapiens	117-131
24524362-4	2014	Electrochemical desorption in KOH confirmed that the cis-1 dyad is anchored to the gold surface through its thiol group.	Sulfhydryl Compounds	108-113	suppressor of cytokine signaling 1	Homo sapiens	53-58
24662796-4	2014	In this review we describe how thiol modification of Cys-152 in GAPDH re-routes metabolic pathways in the cell and converts a metabolic enzyme into a pro-apoptotic factor.	Sulfhydryl Compounds	31-36	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	64-69
24778947-8	2014	The appearance of Au adatom islands upon the thiol exchange suggests that the interfacial structures of BP2 and AdSH SAMs are different.	Sulfhydryl Compounds	45-50	BP2	Homo sapiens	104-107
24316317-0	2014	The influence of fatty acids on determination of human serum albumin thiol group.	Sulfhydryl Compounds	69-74	albumin	Homo sapiens	55-68
24591711-5	2014	Plant chloroplasts have versatile thioredoxin systems, including two reductases dependent on ferredoxin and NADPH as reducing power, respectively, several types of thioredoxins, and the system to deliver thiol redox signals to the thylakoid membrane and lumen.	Sulfhydryl Compounds	204-209	thioredoxin	Homo sapiens	34-45
24591711-7	2014	First, light reactions activate the thioredoxin systems via donation of electrons to oxidized ferredoxin and NADP(+), and second, light induces production of reactive oxygen species in chloroplasts which deactivate the components of the thiol redox network.	Sulfhydryl Compounds	237-242	thioredoxin	Homo sapiens	36-47
24316317-1	2014	During investigation of the changes of the Cys34 thiol group of human serum albumin (HSA) (isolated by affinity chromatography with Cibacron Blue (CB)) in diabetes, we found that the HSA-SH content was higher (11-33%) than the total serum thiol content.	Sulfhydryl Compounds	49-54	albumin	Homo sapiens	70-83
24424263-0	2014	Thiol-dependent antioxidant activity of interphotoreceptor retinoid-binding protein.	Sulfhydryl Compounds	0-5	retinol binding protein 3	Bos taurus	40-83
24291645-7	2014	Our data suggest that interaction of As(III) with multiple thiol groups in the yeast Acr3p may facilitate As(III) translocation across the plasma membrane.	Sulfhydryl Compounds	59-64	Arr3p	Saccharomyces cerevisiae S288C	85-90
24399764-4	2014	The interaction between Cys and lysozyme was observed to be non-covalent, suggesting that the thiophilic interaction between the thiol group on the side chain of Cys and the core sequence of lysozyme significantly contributes to the inhibition of amyloid aggregation.	Sulfhydryl Compounds	129-134	lysozyme	Homo sapiens	32-40
24399764-4	2014	The interaction between Cys and lysozyme was observed to be non-covalent, suggesting that the thiophilic interaction between the thiol group on the side chain of Cys and the core sequence of lysozyme significantly contributes to the inhibition of amyloid aggregation.	Sulfhydryl Compounds	129-134	lysozyme	Homo sapiens	191-199
24374250-1	2014	Thioredoxin (Trx) is a protein disulfide reductase that, together with nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin reductase (TrxR), controls oxidative stress or redox signaling via thiol redox control.	Sulfhydryl Compounds	206-211	thioredoxin	Homo sapiens	0-11
24374250-1	2014	Thioredoxin (Trx) is a protein disulfide reductase that, together with nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin reductase (TrxR), controls oxidative stress or redox signaling via thiol redox control.	Sulfhydryl Compounds	206-211	thioredoxin	Homo sapiens	13-16
24374250-1	2014	Thioredoxin (Trx) is a protein disulfide reductase that, together with nicotinamide adenine dinucleotide phosphate (NADPH) and thioredoxin reductase (TrxR), controls oxidative stress or redox signaling via thiol redox control.	Sulfhydryl Compounds	206-211	peroxiredoxin 5	Homo sapiens	150-154
24424263-1	2014	Interphotoreceptor retinoid-binding protein (IRBP), which is critical to photoreceptor survival and function, is comprised of homologous tandem modules each ~300 amino acids, and contains 10 cysteines, possibly 8 as free thiols.	Sulfhydryl Compounds	221-227	retinol binding protein 3	Bos taurus	0-43
24424263-1	2014	Interphotoreceptor retinoid-binding protein (IRBP), which is critical to photoreceptor survival and function, is comprised of homologous tandem modules each ~300 amino acids, and contains 10 cysteines, possibly 8 as free thiols.	Sulfhydryl Compounds	221-227	retinol binding protein 3	Bos taurus	45-49
24424263-3	2014	Our observation that reducing agent 1,4-dithiothreitol dramatically prevents aggregation prompted investigation of possible functions for IRBP"s free thiols.	Sulfhydryl Compounds	150-156	retinol binding protein 3	Bos taurus	138-142
24415753-2	2014	The aim of this study was to explain whether protein disulfide isomerase (PDI) is responsible for the thiol-disulfide rearrangement in the beta-actin molecule of adhering cells.	Sulfhydryl Compounds	102-107	prolyl 4-hydroxylase subunit beta	Homo sapiens	45-72
25208374-2	2014	In the present paper, the GGBP protein was bound on the surface of SPR sensor through thiol coupling method.	Sulfhydryl Compounds	86-91	sepiapterin reductase	Homo sapiens	67-70
24334276-0	2014	Photocontrol of mitotic kinesin Eg5 facilitated by thiol-reactive photochromic molecules incorporated into the loop L5 functional loop.	Sulfhydryl Compounds	51-56	kinesin family member 11	Homo sapiens	32-35
24306780-0	2014	Sulfolobus solfataricus thiol redox puzzle: characterization of an atypical protein disulfide oxidoreductase.	Sulfhydryl Compounds	24-29	sulfurtransferase TusA family protein	Saccharolobus solfataricus	94-108
24467666-9	2014	This effect was mimicked by cysteamine and dithiothreitol, and was unaffected by absence of the PQQDH-related domain, suggesting that beta-alanine transfer onto thiols is catalysed by the ACSF4-U26 adenylation domain, but is physiologically irrelevant.	Sulfhydryl Compounds	161-167	aminoadipate-semialdehyde dehydrogenase	Homo sapiens	188-193
24808735-5	2014	We found that ysa1 mutants did not show increased sensitivity to reactive oxygen species-producing oxidative damage agents, such as hydrogen peroxide and menadione, but exhibited increased sensitivity to diamide, which is a thiol-specific oxidant.	Sulfhydryl Compounds	224-229	ADP-ribose diphosphatase	Saccharomyces cerevisiae S288C	14-18
24415753-2	2014	The aim of this study was to explain whether protein disulfide isomerase (PDI) is responsible for the thiol-disulfide rearrangement in the beta-actin molecule of adhering cells.	Sulfhydryl Compounds	102-107	prolyl 4-hydroxylase subunit beta	Homo sapiens	74-77
24415753-2	2014	The aim of this study was to explain whether protein disulfide isomerase (PDI) is responsible for the thiol-disulfide rearrangement in the beta-actin molecule of adhering cells.	Sulfhydryl Compounds	102-107	POTE ankyrin domain family member F	Homo sapiens	139-149
24415753-8	2014	Third, because of transfection experiments followed by immunoprecipitation and confocal analysis, we provided evidence that PDI binds to the beta-actin Cys(374) thiol.	Sulfhydryl Compounds	161-166	prolyl 4-hydroxylase subunit beta	Homo sapiens	124-127
24415753-8	2014	Third, because of transfection experiments followed by immunoprecipitation and confocal analysis, we provided evidence that PDI binds to the beta-actin Cys(374) thiol.	Sulfhydryl Compounds	161-166	POTE ankyrin domain family member F	Homo sapiens	141-151
24415753-11	2014	Thus, PDI appears to regulate cytoskeletal reorganization by the thiol-disulfide exchange in beta-actin via a redox-dependent mechanism.	Sulfhydryl Compounds	65-70	prolyl 4-hydroxylase subunit beta	Homo sapiens	6-9
24415753-11	2014	Thus, PDI appears to regulate cytoskeletal reorganization by the thiol-disulfide exchange in beta-actin via a redox-dependent mechanism.	Sulfhydryl Compounds	65-70	POTE ankyrin domain family member F	Homo sapiens	93-103
24497506-7	2014	The susceptibility of rNaV1.2 to GVIIJSSG was significantly altered by treating the channels with thiol-oxidizing or disulfide-reducing agents.	Sulfhydryl Compounds	98-103	sodium voltage-gated channel alpha subunit 2	Rattus norvegicus	22-29
24403080-0	2014	Redox control of human mitochondrial outer membrane protein MitoNEET [2Fe-2S] clusters by biological thiols and hydrogen peroxide.	Sulfhydryl Compounds	101-107	CDGSH iron sulfur domain 1	Homo sapiens	60-68
24375799-1	2014	The activity of glucose-6-phosphate dehydrogenase (G6PD) controls a vascular smooth muscle relaxing mechanism promoted by the oxidation of cytosolic NADPH, which has been associated with activation of the 1alpha form of protein kinase G (PKG-1alpha) by a thiol oxidation-elicited subunit dimerization.	Sulfhydryl Compounds	255-260	glucose-6-phosphate dehydrogenase 2	Mus musculus	16-49
24375799-1	2014	The activity of glucose-6-phosphate dehydrogenase (G6PD) controls a vascular smooth muscle relaxing mechanism promoted by the oxidation of cytosolic NADPH, which has been associated with activation of the 1alpha form of protein kinase G (PKG-1alpha) by a thiol oxidation-elicited subunit dimerization.	Sulfhydryl Compounds	255-260	glucose-6-phosphate dehydrogenase 2	Mus musculus	51-55
24403080-5	2014	Importantly, thiol-reduced mitoNEET [2Fe-2S] clusters can be reversibly oxidized by hydrogen peroxide without disruption of the clusters in vitro and in E. coli cells, indicating that mitoNEET may act as a sensor of oxidative signals to regulate mitochondrial functions via its [2Fe-2S] clusters.	Sulfhydryl Compounds	13-18	CDGSH iron sulfur domain 1	Homo sapiens	27-35
24403080-5	2014	Importantly, thiol-reduced mitoNEET [2Fe-2S] clusters can be reversibly oxidized by hydrogen peroxide without disruption of the clusters in vitro and in E. coli cells, indicating that mitoNEET may act as a sensor of oxidative signals to regulate mitochondrial functions via its [2Fe-2S] clusters.	Sulfhydryl Compounds	13-18	CDGSH iron sulfur domain 1	Homo sapiens	184-192
24403080-6	2014	Furthermore, the binding of the type II diabetes drug pioglitazone in mitoNEET effectively inhibits the thiol-mediated reduction of [2Fe-2S] clusters, suggesting that pioglitazone may modulate the function of mitoNEET by blocking the thiol-mediated reduction of [2Fe-2S] clusters in the protein.	Sulfhydryl Compounds	104-109	CDGSH iron sulfur domain 1	Homo sapiens	70-78
24403080-6	2014	Furthermore, the binding of the type II diabetes drug pioglitazone in mitoNEET effectively inhibits the thiol-mediated reduction of [2Fe-2S] clusters, suggesting that pioglitazone may modulate the function of mitoNEET by blocking the thiol-mediated reduction of [2Fe-2S] clusters in the protein.	Sulfhydryl Compounds	104-109	CDGSH iron sulfur domain 1	Homo sapiens	209-217
24403080-6	2014	Furthermore, the binding of the type II diabetes drug pioglitazone in mitoNEET effectively inhibits the thiol-mediated reduction of [2Fe-2S] clusters, suggesting that pioglitazone may modulate the function of mitoNEET by blocking the thiol-mediated reduction of [2Fe-2S] clusters in the protein.	Sulfhydryl Compounds	234-239	CDGSH iron sulfur domain 1	Homo sapiens	70-78
24403080-6	2014	Furthermore, the binding of the type II diabetes drug pioglitazone in mitoNEET effectively inhibits the thiol-mediated reduction of [2Fe-2S] clusters, suggesting that pioglitazone may modulate the function of mitoNEET by blocking the thiol-mediated reduction of [2Fe-2S] clusters in the protein.	Sulfhydryl Compounds	234-239	CDGSH iron sulfur domain 1	Homo sapiens	209-217
24402840-4	2014	Reaction of solvated complex [(2-CH2CO-6-HOC5H3N)Fe(CO)2(CH3CN)2](+)(BF4)(-) with thiols or thiophenols in the presence of NEt3 yielded 5-coordinate iron thiolate complexes.	Sulfhydryl Compounds	82-88	tetraspanin 2	Homo sapiens	123-127
24400664-3	2014	Peptide mimics of bone morphogenetic protein 2 (BMP-2) were synthesized by solid phase Fmoc-peptide synthesis and covalently bound to alginate hydrogels via either carbodiimide or sulfhydryl-based coupling strategies.	Sulfhydryl Compounds	180-190	bone morphogenetic protein 2	Mus musculus	18-46
24400664-3	2014	Peptide mimics of bone morphogenetic protein 2 (BMP-2) were synthesized by solid phase Fmoc-peptide synthesis and covalently bound to alginate hydrogels via either carbodiimide or sulfhydryl-based coupling strategies.	Sulfhydryl Compounds	180-190	bone morphogenetic protein 2	Mus musculus	48-53
24422500-1	2014	Mammalian thioredoxin reductase (TR) is a pyridine nucleotide disulfide oxidoreductase that uses the rare amino acid selenocysteine (Sec) in place of the more commonly used amino acid cysteine (Cys) in the redox-active tetrapeptide Gly-Cys-Sec-Gly motif to catalyze thiol/disulfide exchange reactions.	Sulfhydryl Compounds	266-271	peroxiredoxin 5	Homo sapiens	10-31
24422500-1	2014	Mammalian thioredoxin reductase (TR) is a pyridine nucleotide disulfide oxidoreductase that uses the rare amino acid selenocysteine (Sec) in place of the more commonly used amino acid cysteine (Cys) in the redox-active tetrapeptide Gly-Cys-Sec-Gly motif to catalyze thiol/disulfide exchange reactions.	Sulfhydryl Compounds	266-271	peroxiredoxin 5	Homo sapiens	33-35
24283831-1	2014	BACKGROUND: von Willebrand factor (VWF) contains free thiols that mass spectroscopy has located to nine cysteines: two in the D3 domain (Cys889 and Cys898) and seven in the C domains (Cys2448, Cys2451, Cys2453, Cys2490, Cys2491, Cys2528, and Cys2533) (J Biol Chem, 7, 2007, 35604; Blood, 118, 5312).	Sulfhydryl Compounds	54-60	von Willebrand factor	Homo sapiens	12-33
24337902-4	2014	MSH provoked a dose-response reversal of the redox state of aged plasma, and the thiol action was confirmed by in vivo experiments.	Sulfhydryl Compounds	81-86	msh homeobox 2	Homo sapiens	0-3
23931157-4	2014	The co-incubation of the cells with Ind, at a nutritionally relevant concentration (5-25 muM), and IL-1beta prevented the release of the pro-inflammatory cytokines IL-6 and IL-8, PGE2 and NO, the formation of ROS and the loss of thiols in a dose-dependent manner.	Sulfhydryl Compounds	229-235	interleukin 1 beta	Homo sapiens	99-107
24418125-5	2014	The majority of the oxidized thiol sperm proteins identified correspond to structural molecules of the flagellum (as the outer dense fiber-1 protein - ODF1), followed by glycolytic enzymes (as glyceraldehyde-3-phosphate dehydrogenase spermatogenic), antioxidant protectors (as glutathione S-transferase and phospholipid hydroperoxide glutathione peroxidase - PHGPx).	Sulfhydryl Compounds	29-34	outer dense fiber of sperm tails 1	Homo sapiens	151-155
24418125-5	2014	The majority of the oxidized thiol sperm proteins identified correspond to structural molecules of the flagellum (as the outer dense fiber-1 protein - ODF1), followed by glycolytic enzymes (as glyceraldehyde-3-phosphate dehydrogenase spermatogenic), antioxidant protectors (as glutathione S-transferase and phospholipid hydroperoxide glutathione peroxidase - PHGPx).	Sulfhydryl Compounds	29-34	glutathione peroxidase 4	Homo sapiens	359-364
24418125-6	2014	The magnitude of the thiol oxidation differs between proteins, and was more drastic in polypeptides with molecular weights of up to 33kDa, identified as ODF1 and PHGPx.	Sulfhydryl Compounds	21-26	outer dense fiber of sperm tails 1	Homo sapiens	153-157
24418125-6	2014	The magnitude of the thiol oxidation differs between proteins, and was more drastic in polypeptides with molecular weights of up to 33kDa, identified as ODF1 and PHGPx.	Sulfhydryl Compounds	21-26	glutathione peroxidase 4	Homo sapiens	162-167
24357063-0	2014	Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner.	Sulfhydryl Compounds	145-150	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	21-29
24357063-8	2014	CONCLUSIONS: Our results demonstrate for the first time that the carboxyl terminus of ADAMTS13 has direct antithrombotic activity in a free-thiol-dependent manner.	Sulfhydryl Compounds	140-145	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	86-94
24357063-9	2014	The free thiols in the carboxyl-terminal domains of ADAMTS13 may also contribute to the overall antithrombotic function of ADAMTS13 under pathophysiological conditions.	Sulfhydryl Compounds	9-15	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	52-60
24357063-9	2014	The free thiols in the carboxyl-terminal domains of ADAMTS13 may also contribute to the overall antithrombotic function of ADAMTS13 under pathophysiological conditions.	Sulfhydryl Compounds	9-15	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	123-131
24318045-1	2014	Heterotelechelic, hydrophilic polymers with a primary amine and thiol group at the alpha- and omega-chain end, respectively, are synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization in a straightforward and versatile way and subsequently used for the design of dual-responsive polymer/gold nanohybrids.	Sulfhydryl Compounds	64-69	Fc gamma receptor and transporter	Homo sapiens	83-105
24283831-1	2014	BACKGROUND: von Willebrand factor (VWF) contains free thiols that mass spectroscopy has located to nine cysteines: two in the D3 domain (Cys889 and Cys898) and seven in the C domains (Cys2448, Cys2451, Cys2453, Cys2490, Cys2491, Cys2528, and Cys2533) (J Biol Chem, 7, 2007, 35604; Blood, 118, 5312).	Sulfhydryl Compounds	54-60	von Willebrand factor	Homo sapiens	35-38
24283831-2	2014	It has been suggested that these free thiols function to regulate the self-association of VWF through thiol-disulfide exchange (J Biol Chem, 7, 2007, 35604; Blood, 118, 5312).	Sulfhydryl Compounds	38-44	von Willebrand factor	Homo sapiens	90-93
24283831-2	2014	It has been suggested that these free thiols function to regulate the self-association of VWF through thiol-disulfide exchange (J Biol Chem, 7, 2007, 35604; Blood, 118, 5312).	Sulfhydryl Compounds	38-43	von Willebrand factor	Homo sapiens	90-93
24283831-10	2014	CONCLUSIONS: These data suggest: first, that pairing of cysteines implicated in free thiol exchange is essential for correct folding of the VWF molecule, and unpairing must occur following exit from the ER or secretion from the cell; and second, that intact C domains are essential for efficient VWF secretion and must interact in the ER.	Sulfhydryl Compounds	85-90	von Willebrand factor	Homo sapiens	140-143
24283831-10	2014	CONCLUSIONS: These data suggest: first, that pairing of cysteines implicated in free thiol exchange is essential for correct folding of the VWF molecule, and unpairing must occur following exit from the ER or secretion from the cell; and second, that intact C domains are essential for efficient VWF secretion and must interact in the ER.	Sulfhydryl Compounds	85-90	von Willebrand factor	Homo sapiens	296-299
24387165-5	2014	The M06-2X/6-311++G(2df,2p) (M1) method was found to give the best performance in reproducing the reported 16 pKa"s of thiols, with a standard deviation (SD) of about 0.5 pKa unit.	Sulfhydryl Compounds	119-125	myoregulin	Homo sapiens	29-31
24338014-5	2014	From the crystal structure of plasminogen, we propose that plasmin ligands such as phosphoglycerate kinase induce a conformational change in reduced kringle 5 that leads to attack by the Cys(541) thiolate anion on the Cys(536) sulfur atom of the Cys(512)-Cys(536) disulfide bond, resulting in reduction of the bond by thiol/disulfide exchange.	Sulfhydryl Compounds	196-201	plasminogen	Homo sapiens	30-37
23318452-10	2014	Loss of Lto1 function renders cells susceptible to hydroperoxide pro-oxidants, though this type of sensitivity is specific to certain types of oxidative stress as the lto1 mutants are not sensitive to an agent that oxidizes thiols.	Sulfhydryl Compounds	224-230	ribosome biosynthesis protein LTO1	Saccharomyces cerevisiae S288C	8-12
24387165-6	2014	Meanwhile, the M1 method was found to be excellent in reproducing the gas phase Gibbs free energies of 17 thiols, providing extra evidence for the reliability of the M1 method in treating thiol systems.	Sulfhydryl Compounds	106-112	myoregulin	Homo sapiens	15-17
24387165-6	2014	Meanwhile, the M1 method was found to be excellent in reproducing the gas phase Gibbs free energies of 17 thiols, providing extra evidence for the reliability of the M1 method in treating thiol systems.	Sulfhydryl Compounds	106-112	myoregulin	Homo sapiens	166-168
24387165-6	2014	Meanwhile, the M1 method was found to be excellent in reproducing the gas phase Gibbs free energies of 17 thiols, providing extra evidence for the reliability of the M1 method in treating thiol systems.	Sulfhydryl Compounds	106-111	myoregulin	Homo sapiens	15-17
24387165-6	2014	Meanwhile, the M1 method was found to be excellent in reproducing the gas phase Gibbs free energies of 17 thiols, providing extra evidence for the reliability of the M1 method in treating thiol systems.	Sulfhydryl Compounds	106-111	myoregulin	Homo sapiens	166-168
24387165-7	2014	On this basis, M1 was then used to predict the pKa"s of 291 thiols whose experimental pKa values remain unknown.	Sulfhydryl Compounds	60-66	myoregulin	Homo sapiens	15-17
24342608-5	2014	Of note, TGF-beta-mediated induction of HMGA2, a central mediator of EMT and metastatic progression, was similarly impaired by TXN2 expression, revealing a novel mechanism involving a thiol oxidation reaction in mitochondria, which regulates TGF-beta-mediated gene expression associated with EMT.	Sulfhydryl Compounds	184-189	transforming growth factor, beta 1	Mus musculus	9-17
24465767-6	2014	Several commercial available strains with the disruption of thiol-redox pathways, and/or co-expression of redoxase or refolding chaperones were used to develop this novel method for expression of FGF15/FGF19 in E. coli.	Sulfhydryl Compounds	60-65	fibroblast growth factor 15	Mus musculus	196-201
24465767-6	2014	Several commercial available strains with the disruption of thiol-redox pathways, and/or co-expression of redoxase or refolding chaperones were used to develop this novel method for expression of FGF15/FGF19 in E. coli.	Sulfhydryl Compounds	60-65	fibroblast growth factor 15	Mus musculus	202-207
24465767-8	2014	However, TRX fusion protein improved FGF19 solubility in strains of thiol-redox system mutants.	Sulfhydryl Compounds	68-73	fibroblast growth factor 15	Mus musculus	37-42
24465767-9	2014	In addition, DsbC co-expressed in thiol-redox system mutants alone improved and further enhanced FGF19 solubility with combination of TRX fusion tag.	Sulfhydryl Compounds	34-39	putative protein DsbC	Escherichia coli	13-17
24465767-9	2014	In addition, DsbC co-expressed in thiol-redox system mutants alone improved and further enhanced FGF19 solubility with combination of TRX fusion tag.	Sulfhydryl Compounds	34-39	fibroblast growth factor 15	Mus musculus	97-102
24342608-5	2014	Of note, TGF-beta-mediated induction of HMGA2, a central mediator of EMT and metastatic progression, was similarly impaired by TXN2 expression, revealing a novel mechanism involving a thiol oxidation reaction in mitochondria, which regulates TGF-beta-mediated gene expression associated with EMT.	Sulfhydryl Compounds	184-189	high mobility group AT-hook 2	Mus musculus	40-45
24342608-5	2014	Of note, TGF-beta-mediated induction of HMGA2, a central mediator of EMT and metastatic progression, was similarly impaired by TXN2 expression, revealing a novel mechanism involving a thiol oxidation reaction in mitochondria, which regulates TGF-beta-mediated gene expression associated with EMT.	Sulfhydryl Compounds	184-189	thioredoxin 2	Mus musculus	127-131
24342608-5	2014	Of note, TGF-beta-mediated induction of HMGA2, a central mediator of EMT and metastatic progression, was similarly impaired by TXN2 expression, revealing a novel mechanism involving a thiol oxidation reaction in mitochondria, which regulates TGF-beta-mediated gene expression associated with EMT.	Sulfhydryl Compounds	184-189	transforming growth factor, beta 1	Mus musculus	242-250
24494201-7	2014	Neither metabolic stress nor UA supplementation altered mRNA or protein levels of glutaredoxin-1, the principal enzyme responsible for the reduction of mixed disulfides between glutathione and protein thiols in these cells.	Sulfhydryl Compounds	201-207	glutaredoxin	Mus musculus	82-96
24341642-4	2014	The chemically modified IL-4 analogues consist of (1) mixed disulfides created by refolding IL-4 cysteine muteins in the presence of different thiol compounds or (2) maleimide conjugates created by modifying cysteine muteins with maleimide derivatives.	Sulfhydryl Compounds	143-148	interleukin 4	Homo sapiens	24-28
23978514-8	2014	Mercury immobilized metal affinity chromatography (Hg-IMAC) demonstrated high selectivity and specificity while enriching for thiol-containing peptides from the atypical dual specificity phosphatase hYVH1 (also known as DUSP12).	Sulfhydryl Compounds	126-131	C-C motif chemokine ligand 26	Homo sapiens	54-58
23978514-8	2014	Mercury immobilized metal affinity chromatography (Hg-IMAC) demonstrated high selectivity and specificity while enriching for thiol-containing peptides from the atypical dual specificity phosphatase hYVH1 (also known as DUSP12).	Sulfhydryl Compounds	126-131	dual specificity phosphatase 12	Homo sapiens	199-204
23978514-9	2014	This approach revealed several reversibly oxidized thiols within the catalytic domain of hYVH1.	Sulfhydryl Compounds	51-57	dual specificity phosphatase 12	Homo sapiens	89-94
23978514-4	2014	Accumulating evidence has revealed diverse mechanisms adopted by PTPs to avoid irreversible thiol oxidation of the active site Cys residue, often involving structurally proximal thiols within the active site region.	Sulfhydryl Compounds	92-97	6-pyruvoyltetrahydropterin synthase	Homo sapiens	65-69
23978514-4	2014	Accumulating evidence has revealed diverse mechanisms adopted by PTPs to avoid irreversible thiol oxidation of the active site Cys residue, often involving structurally proximal thiols within the active site region.	Sulfhydryl Compounds	178-184	6-pyruvoyltetrahydropterin synthase	Homo sapiens	65-69
23978514-5	2014	Therefore, there has been a significant effort made to develop thiol labeling strategies coupled to mass spectrometry to identify and characterize redox sensitive thiols within PTPs as a necessary step in understanding how a particular PTP is regulated by redox signaling.	Sulfhydryl Compounds	63-68	6-pyruvoyltetrahydropterin synthase	Homo sapiens	177-181
23978514-5	2014	Therefore, there has been a significant effort made to develop thiol labeling strategies coupled to mass spectrometry to identify and characterize redox sensitive thiols within PTPs as a necessary step in understanding how a particular PTP is regulated by redox signaling.	Sulfhydryl Compounds	63-68	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	177-180
23978514-5	2014	Therefore, there has been a significant effort made to develop thiol labeling strategies coupled to mass spectrometry to identify and characterize redox sensitive thiols within PTPs as a necessary step in understanding how a particular PTP is regulated by redox signaling.	Sulfhydryl Compounds	163-169	6-pyruvoyltetrahydropterin synthase	Homo sapiens	177-181
23978514-5	2014	Therefore, there has been a significant effort made to develop thiol labeling strategies coupled to mass spectrometry to identify and characterize redox sensitive thiols within PTPs as a necessary step in understanding how a particular PTP is regulated by redox signaling.	Sulfhydryl Compounds	163-169	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	177-180
24341508-7	2014	Deprotection of the C11-S-TFA gave a free thiol allowed patterning of gold nanoparticles on the surface as verified using scanning electron microscopy (SEM).	Sulfhydryl Compounds	42-47	aldo-keto reductase family 1 member C4	Homo sapiens	20-23
24225492-4	2014	The principle of this approach is based on the hydrolysis of acetylthiocholine (ATCh) by AChE, which yields the thiol-bearing compound thiocholine (TCh) that at trace concentrations stabilized the in situ generated CdS quantum dots (QDs).	Sulfhydryl Compounds	112-117	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-93
24409188-2	2014	Thioredoxin1 (Trx1) and Thioredoxin2 (Trx2), mainly located in the cytoplasm and mitochondria, respectively, are ubiquitously expressed in variety of cells and control cellular reactive oxygen species by reducing the disulfides into thiol groups.	Sulfhydryl Compounds	233-238	thioredoxin	Homo sapiens	14-18
24409188-2	2014	Thioredoxin1 (Trx1) and Thioredoxin2 (Trx2), mainly located in the cytoplasm and mitochondria, respectively, are ubiquitously expressed in variety of cells and control cellular reactive oxygen species by reducing the disulfides into thiol groups.	Sulfhydryl Compounds	233-238	thioredoxin 2	Homo sapiens	24-36
24409188-2	2014	Thioredoxin1 (Trx1) and Thioredoxin2 (Trx2), mainly located in the cytoplasm and mitochondria, respectively, are ubiquitously expressed in variety of cells and control cellular reactive oxygen species by reducing the disulfides into thiol groups.	Sulfhydryl Compounds	233-238	thioredoxin 2	Homo sapiens	38-42
24354364-1	2014	delta-Thiolactones derived from thiol-based glutamate carboxypeptidase II (GCPII) inhibitors were evaluated as prodrugs.	Sulfhydryl Compounds	32-37	folate hydrolase 1	Rattus norvegicus	44-73
24354364-1	2014	delta-Thiolactones derived from thiol-based glutamate carboxypeptidase II (GCPII) inhibitors were evaluated as prodrugs.	Sulfhydryl Compounds	32-37	folate hydrolase 1	Rattus norvegicus	75-80
24351040-4	2014	It was demonstrated in vitro that TRFS-green manifests high selectivity toward TrxR over other related enzymes and various small molecule thiols as well as biological reducing molecules.	Sulfhydryl Compounds	138-144	peroxiredoxin 5	Homo sapiens	79-83
25556440-6	2014	Here, 4-HNE could inhibit the deacetylase activity of SIRT3 by thiol-specific modification.	Sulfhydryl Compounds	63-68	elastase, neutrophil expressed	Homo sapiens	8-11
24254994-5	2014	A-kinase anchor protein 4, fatty acid-binding protein 9 (FABP9), glutathione S-transferase mu 5 and voltage-dependent anion channel 2 exhibited changes in thiol status between caput and cauda epididymal spermatozoa.	Sulfhydryl Compounds	155-160	LOC102642117	Mus musculus	0-25
24254994-5	2014	A-kinase anchor protein 4, fatty acid-binding protein 9 (FABP9), glutathione S-transferase mu 5 and voltage-dependent anion channel 2 exhibited changes in thiol status between caput and cauda epididymal spermatozoa.	Sulfhydryl Compounds	155-160	fatty acid binding protein 9, testis	Mus musculus	27-55
24254994-5	2014	A-kinase anchor protein 4, fatty acid-binding protein 9 (FABP9), glutathione S-transferase mu 5 and voltage-dependent anion channel 2 exhibited changes in thiol status between caput and cauda epididymal spermatozoa.	Sulfhydryl Compounds	155-160	fatty acid binding protein 9, testis	Mus musculus	57-62
24254994-5	2014	A-kinase anchor protein 4, fatty acid-binding protein 9 (FABP9), glutathione S-transferase mu 5 and voltage-dependent anion channel 2 exhibited changes in thiol status between caput and cauda epididymal spermatozoa.	Sulfhydryl Compounds	155-160	glutathione S-transferase, mu 5	Mus musculus	65-95
25123250-3	2014	Lipoic acid (LA) and its active metabolite dihydrolipoic acid (DHLA) are naturally occurring thiols that act as cofactors and antioxidants, and are produced by lipoic acid synthetase (LIAS).	Sulfhydryl Compounds	93-99	lipoic acid synthetase	Homo sapiens	184-188
24213855-0	2014	Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles.	Sulfhydryl Compounds	50-55	NIMA related kinase 2	Homo sapiens	44-48
25556440-6	2014	Here, 4-HNE could inhibit the deacetylase activity of SIRT3 by thiol-specific modification.	Sulfhydryl Compounds	63-68	sirtuin 3	Homo sapiens	54-59
24389598-6	2014	Unlike S100A9, S100A8 effectively scavenges oxidants generated by the myeloperoxidase system in vivo, forming novel thiol modifications.	Sulfhydryl Compounds	116-121	S100 calcium binding protein A8	Homo sapiens	15-21
24112082-3	2014	We hypothesized that this thiol-specific oxidant may target the Zn(2+)-thiol cluster of eNOS (endothelial nitric oxide synthase), resulting in enzyme dysfunction and reduced formation of the critical signalling molecule NO .	Sulfhydryl Compounds	26-31	nitric oxide synthase 3	Homo sapiens	94-127
25177688-3	2014	RESULTS: PBE and catechin decreased basal ROS generation in slices and blunted the prooxidant effects of neurotoxicants on membrane lipid peroxidation and nonprotein thiol contents.	Sulfhydryl Compounds	166-171	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	9-12
24332493-2	2014	The SAR was investigated by systematic variation of the pendant thiol, alkyl and pyrimidinol groups.	Sulfhydryl Compounds	64-69	sarcosine dehydrogenase	Homo sapiens	4-7
24389598-6	2014	Unlike S100A9, S100A8 effectively scavenges oxidants generated by the myeloperoxidase system in vivo, forming novel thiol modifications.	Sulfhydryl Compounds	116-121	myeloperoxidase	Homo sapiens	70-85
23701547-7	2014	PEN exhibits a cytotoxic activity on some human tumor cell lines, whose mechanism is attributable to the oxidation of critical thiols located on adenine nucleotide translocase, the protein mainly involved in PTP.	Sulfhydryl Compounds	127-133	protein tyrosine phosphatase receptor type U	Homo sapiens	208-211
24222478-5	2014	Initial attempts to conjugate NMU via the prevalent strategy of reacting a maleimide derivative of the peptide with the free thiol of Cys34 of HSA met with limited success, because the resulting conjugate was unstable in vivo.	Sulfhydryl Compounds	125-130	neuromedin U	Homo sapiens	30-33
24917394-1	2014	Current evidence suggests that endogenous dopamine may act as a neurotoxin following its oxidation to an oquinone and reaction with cellular thiols, which are neutoxic, which may occur spontaneously or via reaction with tyrosinase or some other enzymes.	Sulfhydryl Compounds	141-147	tyrosinase	Homo sapiens	220-230
23899494-2	2014	The Trx system provides the electrons to thiol-dependent peroxidases (peroxiredoxins) to remove reactive oxygen and nitrogen species with a fast reaction rate.	Sulfhydryl Compounds	41-46	thioredoxin	Homo sapiens	4-7
23899494-8	2014	Many bacterial species possess specific thiol-dependent antioxidant systems, and the significance of the Trx system in the defense against oxidative stress is different.	Sulfhydryl Compounds	40-45	thioredoxin	Homo sapiens	105-108
24170778-0	2014	Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.	Sulfhydryl Compounds	95-100	paraoxonase 1	Homo sapiens	121-134
24170778-0	2014	Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.	Sulfhydryl Compounds	95-100	carboxylesterase 1	Homo sapiens	139-157
24170778-0	2014	Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.	Sulfhydryl Compounds	186-191	paraoxonase 1	Homo sapiens	121-134
24170778-0	2014	Multiple cytochrome P450 isoforms are involved in the generation of a pharmacologically active thiol metabolite, whereas paraoxonase 1 and carboxylesterase 1 catalyze the formation of a thiol metabolite isomer from ticlopidine.	Sulfhydryl Compounds	186-191	carboxylesterase 1	Homo sapiens	139-157
24119307-5	2014	Furthermore, the upregulation of the two low affinity sulfate transporter genes SlST2.1 and SlST4.1 in iron-deficient roots, accompanied by a substantial accumulation of total sulfur and thiols in shoots of iron-starved plants, likely supports an increased root-to-shoot translocation of sulfate.	Sulfhydryl Compounds	187-193	sulfate transporter 2.1-like	Solanum lycopersicum	80-87
24119307-5	2014	Furthermore, the upregulation of the two low affinity sulfate transporter genes SlST2.1 and SlST4.1 in iron-deficient roots, accompanied by a substantial accumulation of total sulfur and thiols in shoots of iron-starved plants, likely supports an increased root-to-shoot translocation of sulfate.	Sulfhydryl Compounds	187-193	probable sulfate transporter 4.2-like	Solanum lycopersicum	92-99
24672634-3	2014	We genotyped, in a cohort of ALS patients (n = 145) and healthy controls (n = 168), three SNPs in Nrf2 gene promoter: -653 A/G, -651 G/A, and -617 C/A and evaluated, in a subset (n = 73) of patients, advanced oxidation protein products (AOPP), iron-reducing ability of plasma (FRAP), and plasma thiols (-SH) as oxidative damage peripheral biomarkers.	Sulfhydryl Compounds	295-301	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
24202912-5	2014	Here, we show selective activation of TRPA1 channels by novel NO donors derived from the ABBH (7-azabenzobicyclo[2.2.1]heptane) N-nitrosamines, which exhibit transnitrosylation reactivity to thiols without releasing NO.	Sulfhydryl Compounds	191-197	transient receptor potential cation channel subfamily A member 1	Homo sapiens	38-43
25171296-1	2014	The compound 4-tert-butyl-2,6-bis(thiomorpholin-4-ylmethyl)phenol (TBTIF) has molecular characteristics similar to angiotensin-converting enzyme (ACE) inhibitors of the sulfhydryl subclass.	Sulfhydryl Compounds	169-179	angiotensin I converting enzyme	Rattus norvegicus	146-149
25460734-2	2014	As a substrate of myeloperoxidase in vitro, serotonin is oxidized to tryptamine-4,5-dione (TD), which is highly reactive with thiols.	Sulfhydryl Compounds	126-132	myeloperoxidase	Homo sapiens	18-33
32481977-5	2013	The disulfide bonds in protein bovine alpha-lactalbumin (BLA) can be ruptured by controlled UV illumination, which triggers the formation of nano-sized protein aggregates and releases free thiol groups for the modification of the active targeting ligand of circular RGD peptide.	Sulfhydryl Compounds	189-194	lactalbumin alpha	Bos taurus	38-55
24379783-2	2013	In blood vessels, it is synthesized in a dynamic fashion by endothelial nitric oxide synthase (eNOS) and influences vascular function via two distinct mechanisms, the activation of soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-dependent signaling and the S-nitrosylation of proteins with reactive thiols (S-nitrosylation).	Sulfhydryl Compounds	320-326	nitric oxide synthase 3	Homo sapiens	60-93
24299064-9	2013	The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product.	Sulfhydryl Compounds	58-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
24299064-9	2013	The AChE-catalyzed hydrolysis of acetylthiocholine to the thiol-functionalized thiocholine enabled the probing of the enzymatic activity of AChE through the hemin/G-quadruplex-catalyzed aerobic oxidation of thiocholine to the respective disulfide and the concomitant generation of the fluorescent resorufin product.	Sulfhydryl Compounds	58-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	140-144
24330857-1	2013	BACKGROUND: We examined the underlying mechanism of action of the peptide triazole thiol, KR13 that has been shown previously to specifically bind gp120, block cell receptor site interactions and potently inhibit HIV-1 infectivity.	Sulfhydryl Compounds	83-88	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	147-152
24379783-2	2013	In blood vessels, it is synthesized in a dynamic fashion by endothelial nitric oxide synthase (eNOS) and influences vascular function via two distinct mechanisms, the activation of soluble guanylyl cyclase (sGC)/cyclic guanosine monophosphate (cGMP)-dependent signaling and the S-nitrosylation of proteins with reactive thiols (S-nitrosylation).	Sulfhydryl Compounds	320-326	nitric oxide synthase 3	Homo sapiens	95-99
24415795-2	2013	The thiol-reactive sensor becomes intensely fluorescent upon exposure to thiols from N-acetylcysteine, bovine serum albumin, or human hair (pretreated with a reducing agent to reveal cysteine thiols in alpha-keratin).	Sulfhydryl Compounds	4-9	albumin	Homo sapiens	110-123
24277839-2	2013	Oxidoreductases of the thioredoxin family are key players conveying redox signals through reversible posttranslational modifications of protein thiols.	Sulfhydryl Compounds	144-150	thioredoxin	Danio rerio	23-34
24415795-2	2013	The thiol-reactive sensor becomes intensely fluorescent upon exposure to thiols from N-acetylcysteine, bovine serum albumin, or human hair (pretreated with a reducing agent to reveal cysteine thiols in alpha-keratin).	Sulfhydryl Compounds	73-79	albumin	Homo sapiens	110-123
24324676-4	2013	The amino group of C3(BHam)2 was converted to a maleimide group, and was coupled to thiol groups of annexin A5 pretreated with 2-iminothiolane.	Sulfhydryl Compounds	84-89	complement component 3	Mus musculus	19-28
24324676-4	2013	The amino group of C3(BHam)2 was converted to a maleimide group, and was coupled to thiol groups of annexin A5 pretreated with 2-iminothiolane.	Sulfhydryl Compounds	84-89	annexin A5	Mus musculus	100-110
24323934-10	2013	ROS is thought to modify the thiol residue of Keap1 and to facilitate Nrf2 dissociation from Keap1.	Sulfhydryl Compounds	29-34	kelch like ECH associated protein 1	Homo sapiens	46-51
23994225-6	2013	Our analysis revealed a time-dependent increase in the number of oxidized thiol proteins after carcinogen treatment; some of these proteins have antioxidant activity, including thioredoxin, peroxirredoxin 2, peroxiredoxin 6 and glutathione S-transferase alpha-3.	Sulfhydryl Compounds	74-79	thioredoxin 1	Rattus norvegicus	177-188
23994225-6	2013	Our analysis revealed a time-dependent increase in the number of oxidized thiol proteins after carcinogen treatment; some of these proteins have antioxidant activity, including thioredoxin, peroxirredoxin 2, peroxiredoxin 6 and glutathione S-transferase alpha-3.	Sulfhydryl Compounds	74-79	glutathione S-transferase alpha-3	Rattus norvegicus	228-261
23496095-7	2013	The production of thiol-peptides was induced by all the metals, alone or in combination, and the expression of the genes involved in thiol-peptide synthesis (AtGSH1, AtGSH2, AtPCS1 and AtPCS2) was not stimulated by the metals, suggesting a full post-transcriptional control.	Sulfhydryl Compounds	18-23	phytochelatin synthase 2	Arabidopsis thaliana	185-191
24041654-8	2013	All thirteen compounds lose activity against an RGS4 mutant lacking cysteines, indicating that covalent modification of free thiol groups on RGS4 is a common mechanism.	Sulfhydryl Compounds	125-130	regulator of G protein signaling 4	Homo sapiens	48-52
24041654-8	2013	All thirteen compounds lose activity against an RGS4 mutant lacking cysteines, indicating that covalent modification of free thiol groups on RGS4 is a common mechanism.	Sulfhydryl Compounds	125-130	regulator of G protein signaling 4	Homo sapiens	141-145
24115172-4	2013	We identified 34 spots that exhibited marked changes in intensities, and 13 proteins showing significant changes in thiol reactivity, in response to GR depletion.	Sulfhydryl Compounds	116-121	glutathione-disulfide reductase	Homo sapiens	149-151
24140864-7	2013	Oxidation of the mitochondrial thioredoxin redox circuit would further compromise the transient oxidation of thiol groups within specific proteins, the basis of redox signaling, and the processes by which cells respond to oxidants.	Sulfhydryl Compounds	109-114	thioredoxin 1	Mus musculus	31-42
23496095-7	2013	The production of thiol-peptides was induced by all the metals, alone or in combination, and the expression of the genes involved in thiol-peptide synthesis (AtGSH1, AtGSH2, AtPCS1 and AtPCS2) was not stimulated by the metals, suggesting a full post-transcriptional control.	Sulfhydryl Compounds	133-138	glutamate-cysteine ligase	Arabidopsis thaliana	158-164
23496095-7	2013	The production of thiol-peptides was induced by all the metals, alone or in combination, and the expression of the genes involved in thiol-peptide synthesis (AtGSH1, AtGSH2, AtPCS1 and AtPCS2) was not stimulated by the metals, suggesting a full post-transcriptional control.	Sulfhydryl Compounds	133-138	glutathione synthetase 2	Arabidopsis thaliana	166-172
23496095-7	2013	The production of thiol-peptides was induced by all the metals, alone or in combination, and the expression of the genes involved in thiol-peptide synthesis (AtGSH1, AtGSH2, AtPCS1 and AtPCS2) was not stimulated by the metals, suggesting a full post-transcriptional control.	Sulfhydryl Compounds	133-138	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	174-180
23496095-7	2013	The production of thiol-peptides was induced by all the metals, alone or in combination, and the expression of the genes involved in thiol-peptide synthesis (AtGSH1, AtGSH2, AtPCS1 and AtPCS2) was not stimulated by the metals, suggesting a full post-transcriptional control.	Sulfhydryl Compounds	133-138	phytochelatin synthase 2	Arabidopsis thaliana	185-191
24302985-3	2013	As S4 of the human skeletal muscle voltage-gated sodium channel, hNav1.4, moves in response to depolarization from the resting to the inactivated state, two D4S4 reporters (R2C and R3C, Arg1451Cys and Arg1454Cys, respectively) move from internal to external positions as deduced by reactivity to internally or externally applied sulfhydryl group reagents, methane thiosulfonates (MTS).	Sulfhydryl Compounds	329-339	sodium voltage-gated channel alpha subunit 4	Homo sapiens	65-72
24064205-6	2013	Disulfiram, a thiol-modifying drug, inhibits both the dehydrogenase and GTN reductase activity of GAPDH, while DTT or tris(2-carboxyethyl)phosphine reverse the GTN-induced inhibition.	Sulfhydryl Compounds	14-19	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	98-103
23871940-6	2013	We compared a thiol-modified hyaluronan (Glycosil ) hydrogel that exhibits a low burst followed by a sustained release of BMP-2 to a collagen sponge for the delivery of three different doses of BMP-2, the bioactivities of released BMP-2 and ectopic bone formation.	Sulfhydryl Compounds	14-19	bone morphogenetic protein 2	Bos taurus	122-127
24102610-2	2013	Since in the crystals of N-acetyl-l-cysteine the thiol group is involved in intermolecular hydrogen bonds not as a donor only (bonds S-H   O) but also as an acceptor (bonds N-H   S), increasing the pressure does not result in phase transitions.	Sulfhydryl Compounds	49-54	shadow of prion protein	Homo sapiens	133-140
24102610-3	2013	This makes a contrast with the polymorphs of l- and dl-cysteine, in which multiple phase transitions are observed already at relatively low hydrostatic pressures and are related to the changes in the conformation of the thiol side chains only weakly bound to the neighboring molecules in the structure and thus easily switching over the weak S-H   O and S-H   S hydrogen bonds.	Sulfhydryl Compounds	220-225	shadow of prion protein	Homo sapiens	342-349
24252617-0	2013	Thiol-functionalized magnetite/graphene oxide hybrid as a reusable adsorbent for Hg2+ removal.	Sulfhydryl Compounds	0-5	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	81-84
24252617-1	2013	A thiol-functionalized magnetite/graphene oxide (MGO) hybrid as an adsorbent of Hg2+ was successfully synthesized by a two-step reaction.	Sulfhydryl Compounds	2-7	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	80-83
24252617-5	2013	The adsorption of Hg2+ by the thiol-functionalized MGO fits well with the Freundlich isotherm model and followed pseudo-second-order kinetics.	Sulfhydryl Compounds	30-35	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	18-21
24008159-6	2013	Recombinant human FH reduced large soluble vWF multimers in a free thiol-dependent reaction that was not inhibited by a variety of protease inhibitors.	Sulfhydryl Compounds	67-72	complement factor H	Homo sapiens	18-20
23872354-8	2013	CONCLUSIONS: Our study demonstrates that Grx2 catalyzes both the specific oxidation and the reduction of cysteinyl residues in the same compartment at the same time and without affecting the global cellular thiol-redox state.	Sulfhydryl Compounds	207-212	glutaredoxin 2	Homo sapiens	41-45
23872476-5	2013	Other thiol-containing compounds were identified as CETP modulators interacting with cysteine 13 of CETP.	Sulfhydryl Compounds	6-11	cholesteryl ester transfer protein	Homo sapiens	52-56
23872476-5	2013	Other thiol-containing compounds were identified as CETP modulators interacting with cysteine 13 of CETP.	Sulfhydryl Compounds	6-11	cholesteryl ester transfer protein	Homo sapiens	100-104
24236211-0	2013	Increased cell surface free thiols identify effector CD8+ T cells undergoing T cell receptor stimulation.	Sulfhydryl Compounds	28-34	CD8a molecule	Homo sapiens	53-56
24236211-3	2013	In this study we used fluorescently labeled conjugates of maleimide to measure the level of cell surface free thiols (CSFT) during the development, activation and differentiation of CD8(+) T cells.	Sulfhydryl Compounds	110-116	CD8a molecule	Homo sapiens	182-185
24062305-2	2013	Besides the active site thiols, human Trx1 contains three non-active site cysteine residues at positions 62, 69, and 73.	Sulfhydryl Compounds	24-30	thioredoxin	Homo sapiens	38-42
24008159-6	2013	Recombinant human FH reduced large soluble vWF multimers in a free thiol-dependent reaction that was not inhibited by a variety of protease inhibitors.	Sulfhydryl Compounds	67-72	von Willebrand factor	Homo sapiens	43-46
23872476-8	2013	Overall, these data demonstrate that the two functions of CETP i.e., cholesteryl ester transfer and HDL remodeling can be uncoupled by interaction of thiol-containing compounds with cysteine 13 of CETP or by introducing large amino acid residues in place of cysteine 13.	Sulfhydryl Compounds	150-155	cholesteryl ester transfer protein	Homo sapiens	58-62
23872476-8	2013	Overall, these data demonstrate that the two functions of CETP i.e., cholesteryl ester transfer and HDL remodeling can be uncoupled by interaction of thiol-containing compounds with cysteine 13 of CETP or by introducing large amino acid residues in place of cysteine 13.	Sulfhydryl Compounds	150-155	cholesteryl ester transfer protein	Homo sapiens	197-201
23871940-6	2013	We compared a thiol-modified hyaluronan (Glycosil ) hydrogel that exhibits a low burst followed by a sustained release of BMP-2 to a collagen sponge for the delivery of three different doses of BMP-2, the bioactivities of released BMP-2 and ectopic bone formation.	Sulfhydryl Compounds	14-19	bone morphogenetic protein 2	Bos taurus	194-199
23871940-6	2013	We compared a thiol-modified hyaluronan (Glycosil ) hydrogel that exhibits a low burst followed by a sustained release of BMP-2 to a collagen sponge for the delivery of three different doses of BMP-2, the bioactivities of released BMP-2 and ectopic bone formation.	Sulfhydryl Compounds	14-19	bone morphogenetic protein 2	Bos taurus	194-199
23913858-2	2013	Protein disulfide isomerase (PDI) is an oxidoreductase that mediates thiol/disulfide interchange reactions.	Sulfhydryl Compounds	69-74	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	29-32
24055038-5	2013	By combining acid quenching and thiol-alkylation, we identified a number of potential redox partners of ERdj5 from the mouse epididymis.	Sulfhydryl Compounds	32-37	DnaJ heat shock protein family (Hsp40) member C10	Mus musculus	104-109
24133142-5	2013	As proof-of-principle, GLP2-2G peptide was chemically conjugated to each of the two XTEN protein polymers using maleimide-thiol chemistry.	Sulfhydryl Compounds	122-127	mast cell protease 10	Rattus norvegicus	23-27
23913858-2	2013	Protein disulfide isomerase (PDI) is an oxidoreductase that mediates thiol/disulfide interchange reactions.	Sulfhydryl Compounds	69-74	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	0-27
23946468-1	2013	Thioredoxin (Trx) and GSH are the major thiol antioxidants protecting cells from oxidative stress-induced cytotoxicity.	Sulfhydryl Compounds	40-45	thioredoxin	Homo sapiens	0-11
23946468-1	2013	Thioredoxin (Trx) and GSH are the major thiol antioxidants protecting cells from oxidative stress-induced cytotoxicity.	Sulfhydryl Compounds	40-45	thioredoxin	Homo sapiens	13-16
24073927-3	2013	We have applied (15)N-edited (1)H NMR techniques to detect the HNO-induced thiol to sulfinamide modification in several small organic molecules, peptides, and the cysteine protease, papain.	Sulfhydryl Compounds	75-80	cathepsin B	Homo sapiens	163-180
24053441-9	2013	In summary, the cysteines in the Walker A motifs of NBDs of human P-gp are differentially accessible to thiol-specific agents in the apo and closed conformations.	Sulfhydryl Compounds	104-109	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
23911883-7	2013	Pre-incubation with thiol antioxidants glutathione or N-acetyl-cysteine(NAC) almost abolished the cytotoxicity of PHII-7.	Sulfhydryl Compounds	20-25	synuclein alpha	Homo sapiens	72-75
24053441-0	2013	Conserved Walker A cysteines 431 and 1074 in human P-glycoprotein are accessible to thiol-specific agents in the apo and ADP-vanadate trapped conformations.	Sulfhydryl Compounds	84-89	ATP binding cassette subfamily B member 1	Homo sapiens	51-65
24066983-2	2013	This mechanism is characterized by the displacement of a coordinating cysteine thiol (or SeCys in Fdh) from the first to the second shell of the Mo-coordination sphere metal.	Sulfhydryl Compounds	79-84	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	98-101
24648762-4	2013	Our results, presented here, show that silencing PrxII gene expression increased cellular toxicity by altering cellular thiol status, inhibiting Ca(2+) efflux from the cells, and perturbing the intracellular Ca(2+) homeostasis.	Sulfhydryl Compounds	120-125	peroxiredoxin 2	Homo sapiens	49-54
23157314-3	2013	For example, it can react with particular protein Cys thiols because of its electrophilicity and can cause unique post-translational modifications of redox-sensor proteins such as Keap1 and H-Ras.	Sulfhydryl Compounds	54-60	kelch-like ECH-associated protein 1	Mus musculus	180-185
23157314-3	2013	For example, it can react with particular protein Cys thiols because of its electrophilicity and can cause unique post-translational modifications of redox-sensor proteins such as Keap1 and H-Ras.	Sulfhydryl Compounds	54-60	Harvey rat sarcoma virus oncogene	Mus musculus	190-195
24025674-4	2013	In contrast, transient ROS generation was not observed with the parental roGFP2 probe without Grx1, which exhibits slower thiol-disulfide exchange.	Sulfhydryl Compounds	122-127	glutaredoxin	Homo sapiens	94-98
23736079-2	2013	Protein thiols are selectively oxidized and reduced in distinct spatial and temporal patterns in conjunction with changes in glutathione/glutathione disulfide (GSH/GSSG) and cysteine/cystine (Cys/CySS) redox potentials (E(h)) to regulate developmental signaling.	Sulfhydryl Compounds	8-14	cystatin S	Rattus norvegicus	196-200
23702245-2	2013	Under physiological conditions glucose metabolism is linked to control of the NADH/NAD redox couple, as well as providing the major reductant, NADPH, for thiol-dependent antioxidant defenses.	Sulfhydryl Compounds	154-159	2,4-dienoyl-CoA reductase 1	Homo sapiens	143-148
23320823-4	2013	In SMP30 KO mice, ACh-induced vasoconstriction occurred, which was changed to vasodilation by dithiothreitol (DTT), a thiol-reducing agent.	Sulfhydryl Compounds	118-123	regucalcin	Mus musculus	3-8
23320823-10	2013	The reduced glutathione and total thiol levels were also low in the aorta of SMP30 KO mice compared with those of WT mice.	Sulfhydryl Compounds	34-39	regucalcin	Mus musculus	77-82
23736079-12	2013	A significant net oxidation was seen in the BSO-treated AF compartment after 6 h. Biotinylated iodoacetamide (BIAM) labeling of proteins revealed the significant thiol oxidation of many EMB proteins following BSO treatment.	Sulfhydryl Compounds	162-167	embigin	Rattus norvegicus	186-189
23583676-6	2013	In contrast, treatment with the thiol-based antioxidant N-acetylcysteine promoted the relocalization of Tms to cortical actin microfilaments and partially rescued the migration defects associated with attenuated LDHA expression.	Sulfhydryl Compounds	32-37	lactate dehydrogenase A	Mus musculus	212-216
23695982-9	2013	Pretreatment with a thiol-containing reactive oxygen species (ROS) scavenger N-acetyl cysteine, but not other ROS inhibitors without thiol groups, suppressed CuB-induced actin aggregation, cofilin hyperactivation and cofilin-actin rod formation, suggesting that thiol oxidation might be involved in these processes.	Sulfhydryl Compounds	20-25	cofilin 1	Homo sapiens	189-196
23695982-9	2013	Pretreatment with a thiol-containing reactive oxygen species (ROS) scavenger N-acetyl cysteine, but not other ROS inhibitors without thiol groups, suppressed CuB-induced actin aggregation, cofilin hyperactivation and cofilin-actin rod formation, suggesting that thiol oxidation might be involved in these processes.	Sulfhydryl Compounds	20-25	cofilin 1	Homo sapiens	217-224
23859815-2	2013	Our system relies on the chemisorption of a thiol-terminated ionic liquid with very low melting point on the surface of L10 FePt nanoparticles.	Sulfhydryl Compounds	44-49	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	120-123
23965518-0	2013	The sulphydryl containing ACE inhibitor Zofenoprilat protects coronary endothelium from Doxorubicin-induced apoptosis.	Sulfhydryl Compounds	4-14	angiotensin I converting enzyme	Homo sapiens	26-29
23987472-6	2013	O-Glycosylation of CD43, a cell surface antigen rich in O-glycans, was drastically reduced by 1 in a thiol-dependent manner.	Sulfhydryl Compounds	101-106	sialophorin	Homo sapiens	19-23
23987472-8	2013	Direct metabolic incorporation of 1 was confirmed by thiol-selective Michael addition reaction of immunoprecipitated CD43-myc/FLAG.	Sulfhydryl Compounds	53-58	sialophorin	Homo sapiens	117-121
23584389-2	2013	In this protocol, one thiol-modified thrombin aptamer (TBA29) was immobilized on gold nanoparticles (AuNPs) via Au-S bonding.	Sulfhydryl Compounds	22-27	coagulation factor II, thrombin	Homo sapiens	37-45
23957891-4	2013	Here we examined the recovery of catalytic activity from two oxidatively inactivated PTPs (PTP1B and SHP-2) by various low-molecular weight thiols and the enzyme thioredoxin.	Sulfhydryl Compounds	140-146	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	91-96
23957891-4	2013	Here we examined the recovery of catalytic activity from two oxidatively inactivated PTPs (PTP1B and SHP-2) by various low-molecular weight thiols and the enzyme thioredoxin.	Sulfhydryl Compounds	140-146	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	101-106
23957891-7	2013	The biological thiol glutathione repaired oxidized PTP1B with an apparent second-order rate constant of 0.023 +- 0.004 M(-1) s(-1), while the dithiol dithiothreitol (DTT) displayed an apparent second-order rate constant of 0.325 +- 0.007 M(-1) s(-1).	Sulfhydryl Compounds	15-20	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	51-56
23957891-12	2013	The common biochemical reducing agent tris(2-carboxyethyl)phosphine regenerates enzymatic activity from oxidized PTP1B somewhat faster than the thiol-based reagents, with a rate constant of 1.5 +- 0.5 M(-1) s(-1).	Sulfhydryl Compounds	144-149	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	113-118
23957891-13	2013	We observed profound kinetic differences between the thiol-dependent regeneration of activity from oxidized PTP1B and SHP-2, highlighting the potential for structural differences in various oxidized PTPs to play a significant role in the rates at which low-molecular weight thiols and thiol-containing enzymes such as thioredoxin and glutaredoxin return catalytic activity to these enzymes during cell signaling events.	Sulfhydryl Compounds	53-58	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	108-113
23957891-13	2013	We observed profound kinetic differences between the thiol-dependent regeneration of activity from oxidized PTP1B and SHP-2, highlighting the potential for structural differences in various oxidized PTPs to play a significant role in the rates at which low-molecular weight thiols and thiol-containing enzymes such as thioredoxin and glutaredoxin return catalytic activity to these enzymes during cell signaling events.	Sulfhydryl Compounds	53-58	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	118-123
23957891-13	2013	We observed profound kinetic differences between the thiol-dependent regeneration of activity from oxidized PTP1B and SHP-2, highlighting the potential for structural differences in various oxidized PTPs to play a significant role in the rates at which low-molecular weight thiols and thiol-containing enzymes such as thioredoxin and glutaredoxin return catalytic activity to these enzymes during cell signaling events.	Sulfhydryl Compounds	53-58	thioredoxin	Homo sapiens	318-329
23957891-13	2013	We observed profound kinetic differences between the thiol-dependent regeneration of activity from oxidized PTP1B and SHP-2, highlighting the potential for structural differences in various oxidized PTPs to play a significant role in the rates at which low-molecular weight thiols and thiol-containing enzymes such as thioredoxin and glutaredoxin return catalytic activity to these enzymes during cell signaling events.	Sulfhydryl Compounds	53-58	glutaredoxin	Homo sapiens	334-346
23957891-13	2013	We observed profound kinetic differences between the thiol-dependent regeneration of activity from oxidized PTP1B and SHP-2, highlighting the potential for structural differences in various oxidized PTPs to play a significant role in the rates at which low-molecular weight thiols and thiol-containing enzymes such as thioredoxin and glutaredoxin return catalytic activity to these enzymes during cell signaling events.	Sulfhydryl Compounds	274-280	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	108-113
23957891-13	2013	We observed profound kinetic differences between the thiol-dependent regeneration of activity from oxidized PTP1B and SHP-2, highlighting the potential for structural differences in various oxidized PTPs to play a significant role in the rates at which low-molecular weight thiols and thiol-containing enzymes such as thioredoxin and glutaredoxin return catalytic activity to these enzymes during cell signaling events.	Sulfhydryl Compounds	274-280	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	118-123
23957891-13	2013	We observed profound kinetic differences between the thiol-dependent regeneration of activity from oxidized PTP1B and SHP-2, highlighting the potential for structural differences in various oxidized PTPs to play a significant role in the rates at which low-molecular weight thiols and thiol-containing enzymes such as thioredoxin and glutaredoxin return catalytic activity to these enzymes during cell signaling events.	Sulfhydryl Compounds	274-279	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	108-113
23957891-13	2013	We observed profound kinetic differences between the thiol-dependent regeneration of activity from oxidized PTP1B and SHP-2, highlighting the potential for structural differences in various oxidized PTPs to play a significant role in the rates at which low-molecular weight thiols and thiol-containing enzymes such as thioredoxin and glutaredoxin return catalytic activity to these enzymes during cell signaling events.	Sulfhydryl Compounds	274-279	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	118-123
23458359-4	2013	Overexpression of genes, such as GCL, G6PD, Prx2, and Prx5, which are involved in the maintenance of thiol redox homeostasis, has strong positive effects on longevity.	Sulfhydryl Compounds	101-106	germ cell-less	Drosophila melanogaster	33-36
23895568-0	2013	Direct and nitroxyl (HNO)-mediated reactions of acyloxy nitroso compounds with the thiol-containing proteins glyceraldehyde 3-phosphate dehydrogenase and alkyl hydroperoxide reductase subunit C. Nitroxyl (HNO) reacts with thiols, and this reactivity requires the use of donors with 1-nitrosocyclohexyl acetate, pivalate, and trifluoroacetate, forming a new group.	Sulfhydryl Compounds	83-88	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	109-149
23895568-0	2013	Direct and nitroxyl (HNO)-mediated reactions of acyloxy nitroso compounds with the thiol-containing proteins glyceraldehyde 3-phosphate dehydrogenase and alkyl hydroperoxide reductase subunit C. Nitroxyl (HNO) reacts with thiols, and this reactivity requires the use of donors with 1-nitrosocyclohexyl acetate, pivalate, and trifluoroacetate, forming a new group.	Sulfhydryl Compounds	222-228	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	109-149
23458359-4	2013	Overexpression of genes, such as GCL, G6PD, Prx2, and Prx5, which are involved in the maintenance of thiol redox homeostasis, has strong positive effects on longevity.	Sulfhydryl Compounds	101-106	Zwischenferment	Drosophila melanogaster	38-42
23458359-4	2013	Overexpression of genes, such as GCL, G6PD, Prx2, and Prx5, which are involved in the maintenance of thiol redox homeostasis, has strong positive effects on longevity.	Sulfhydryl Compounds	101-106	Peroxiredoxin 5	Drosophila melanogaster	54-58
24005034-3	2013	The immobilization of His6-RAGE domains consists of: (i) formation of a mixed layer of N-acetylcysteamine (NAC) and the thiol derivative of pentetic acid (DPTA); (ii) complexation of Cu(II) by DPTA; (iii) oriented immobilization of His6-RAGE domains via coordination bonds between Cu(II) sites from DPTA-Cu(II) complex and imidazole nitrogen atoms of a histidine tag.	Sulfhydryl Compounds	120-125	advanced glycosylation end-product specific receptor	Homo sapiens	27-31
22909029-3	2013	Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).	Sulfhydryl Compounds	46-51	thioredoxin reductase 3	Homo sapiens	97-130
22909029-3	2013	Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).	Sulfhydryl Compounds	46-51	thioredoxin reductase 3	Homo sapiens	132-135
22909029-3	2013	Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).	Sulfhydryl Compounds	46-51	thioredoxin	Homo sapiens	294-297
22909029-3	2013	Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).	Sulfhydryl Compounds	46-51	glutaredoxin	Homo sapiens	152-164
22909029-3	2013	Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).	Sulfhydryl Compounds	46-51	glutaredoxin	Homo sapiens	166-169
22909029-3	2013	Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).	Sulfhydryl Compounds	46-51	thioredoxin	Homo sapiens	97-108
22909029-3	2013	Platyhelminth parasites possess a streamlined thiol-based redox system in which a single enzyme, thioredoxin glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase (TR) domains, supplies electrons to oxidized glutathione (GSSG) and thioredoxin (Trx).	Sulfhydryl Compounds	46-51	thioredoxin	Homo sapiens	191-202
23773140-6	2013	AI-3 is an electrophilic ARE activator with two thiol sensitive sites toward a nucleophilic aromatic substitution, and SAR studies indicated the tunability of the system.	Sulfhydryl Compounds	48-53	family with sequence similarity 83 member H	Homo sapiens	0-4
23924058-2	2013	Here we show that multiple thiol moieties can be placed within a central channel, with approximate dimensions 6 x 42 A, of a de novo, six-helix peptide assembly (CC-Hex).	Sulfhydryl Compounds	27-32	hematopoietically expressed homeobox	Homo sapiens	165-168
23180154-7	2013	Thiol redox status (GSHtotal-2GSSG/GSSG) increased by &gt;50% after alphaLA and exercise (ANOVA, P &lt; 0.05) and correlated with changes in cytokines interleukin-6 (IL-6) (r = -0.478, P &lt; 0.05) and IL-10 (r = -0.455, P &lt; 0.05).	Sulfhydryl Compounds	0-5	interleukin 6	Homo sapiens	151-164
23180154-7	2013	Thiol redox status (GSHtotal-2GSSG/GSSG) increased by &gt;50% after alphaLA and exercise (ANOVA, P &lt; 0.05) and correlated with changes in cytokines interleukin-6 (IL-6) (r = -0.478, P &lt; 0.05) and IL-10 (r = -0.455, P &lt; 0.05).	Sulfhydryl Compounds	0-5	interleukin 6	Homo sapiens	166-170
23180154-7	2013	Thiol redox status (GSHtotal-2GSSG/GSSG) increased by &gt;50% after alphaLA and exercise (ANOVA, P &lt; 0.05) and correlated with changes in cytokines interleukin-6 (IL-6) (r = -0.478, P &lt; 0.05) and IL-10 (r = -0.455, P &lt; 0.05).	Sulfhydryl Compounds	0-5	interleukin 10	Homo sapiens	202-207
23727015-0	2013	Comparative study on methyl- and ethylmercury-induced toxicity in C6 glioma cells and the potential role of LAT-1 in mediating mercurial-thiol complexes uptake.	Sulfhydryl Compounds	137-142	solute carrier family 7 member 5	Homo sapiens	108-113
23792825-6	2013	Both GR and GSH are physiologically linked together where, GR is a NAD(P)H-dependent enzymatic antioxidant and efficiently maintains the reduced pool of GSH - a cellular thiol.	Sulfhydryl Compounds	170-175	glutathione-disulfide reductase	Homo sapiens	5-7
23792825-6	2013	Both GR and GSH are physiologically linked together where, GR is a NAD(P)H-dependent enzymatic antioxidant and efficiently maintains the reduced pool of GSH - a cellular thiol.	Sulfhydryl Compounds	170-175	glutathione-disulfide reductase	Homo sapiens	59-61
23905516-5	2013	The absence of a mode near 220 cm-1 is also inconsistent with a generalization of the suggestion that the 221 cm-1 Raman mode, observed in the P420-CO photoproduct of inducible nitric oxide synthase (iNOS), arises from a thiol-bound ferrous heme.	Sulfhydryl Compounds	221-226	nitric oxide synthase 2	Homo sapiens	167-198
23905516-5	2013	The absence of a mode near 220 cm-1 is also inconsistent with a generalization of the suggestion that the 221 cm-1 Raman mode, observed in the P420-CO photoproduct of inducible nitric oxide synthase (iNOS), arises from a thiol-bound ferrous heme.	Sulfhydryl Compounds	221-226	nitric oxide synthase 2	Homo sapiens	200-204
23207101-5	2013	Notably, only one of the redox forms of HMGB1, the one where all cysteines are reduced (all-thiol), can bind CXCL12.	Sulfhydryl Compounds	92-97	high mobility group box 1	Homo sapiens	40-45
23524147-5	2013	Thiol-labeled single-stranded oligonucleotide probes, which were proved to be superior to amine-labeled probes in immobilization, were immobilized onto the surfaces of the gold spots on the sensor chip to target the specific sequence in the HLA-B*27 gene in blood.	Sulfhydryl Compounds	0-5	major histocompatibility complex, class I, B	Homo sapiens	241-249
23798702-3	2013	In isolated SR (SR vesicles), an average of six to eight Cys thiols/RyR1 monomer are reversibly oxidized at high (21% O2) versus low pO2 (1% O2), but their identity among the 100 Cys residues/RyR1 monomer is unknown.	Sulfhydryl Compounds	61-67	ryanodine receptor 1	Homo sapiens	68-72
23841591-7	2013	Under cytosol-mimicking thiol-rich conditions, RPC-bPEI(0.8 kDa)2/BSA and RPA-bPEI(0.8 kDa)2/LYZ complexes increased significantly in size and released the loaded protein, unlike the protein complexes with nonreducible polyelectrolytes (bPEI(25 kDa) and bPEI(25 kDa)COOH).	Sulfhydryl Compounds	24-29	lysozyme	Homo sapiens	93-96
23793623-0	2013	Roles of the Yap1 transcription factor and antioxidants in Saccharomyces cerevisiae"s tolerance to furfural and 5-hydroxymethylfurfural, which function as thiol-reactive electrophiles generating oxidative stress.	Sulfhydryl Compounds	155-160	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	13-17
23793623-3	2013	In this study, we show that both furfural and HMF act as thiol-reactive electrophiles, thus directly activating the Yap1 transcription factor via the H2O2-independent pathway, depleting cellular glutathione (GSH) levels, and accumulating reactive oxygen species in Saccharomyces cerevisiae.	Sulfhydryl Compounds	57-62	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	116-120
23207101-5	2013	Notably, only one of the redox forms of HMGB1, the one where all cysteines are reduced (all-thiol), can bind CXCL12.	Sulfhydryl Compounds	92-97	C-X-C motif chemokine ligand 12	Homo sapiens	109-115
23702800-1	2013	[RuCl(PPh3)2(3-phenylindenyl)] (1) has been shown to be an efficient catalyst in thiol dehydrogenative coupling to give disulfides.	Sulfhydryl Compounds	81-86	caveolin 1	Homo sapiens	6-10
23923025-2	2013	Oxidative modifications of human serum albumin (HSA), the largest thiol pool in plasma, alter its biological properties and may affect its antioxidant potential in HD patients.	Sulfhydryl Compounds	66-71	albumin	Homo sapiens	33-46
23339572-4	2013	HO-1 expression is triggered by the Nrf2-Keap1 signalling pathway, initiated by the addition of chalcones to thiol groups of Keap1 via Michael-type reaction.	Sulfhydryl Compounds	109-114	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
23339572-4	2013	HO-1 expression is triggered by the Nrf2-Keap1 signalling pathway, initiated by the addition of chalcones to thiol groups of Keap1 via Michael-type reaction.	Sulfhydryl Compounds	109-114	kelch like ECH associated protein 1	Homo sapiens	41-46
23339572-4	2013	HO-1 expression is triggered by the Nrf2-Keap1 signalling pathway, initiated by the addition of chalcones to thiol groups of Keap1 via Michael-type reaction.	Sulfhydryl Compounds	109-114	kelch like ECH associated protein 1	Homo sapiens	125-130
23845496-4	2013	Good selectivity and competition of TSP1 towards sulfite over several anions and biological thiols were acquired.	Sulfhydryl Compounds	92-98	thrombospondin 1	Homo sapiens	36-40
23545271-9	2013	Here, we demonstrate the contribution of cytosolic factors (related to thiol group depletion) on the activation of TRPV1 channels in this mechanism.	Sulfhydryl Compounds	71-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	115-120
23615222-1	2013	Thioredoxin (Trx) is a key player in redox homeostasis in various cells, modulating the functions of target proteins by catalyzing a thiol-disulfide exchange reaction.	Sulfhydryl Compounds	133-138	thioredoxin H-type 1	Arabidopsis thaliana	0-11
23583906-1	2013	To find out whether and how the adenine nucleotide translocator-1 (ANT-1) inhibition due to NH2htau and Abeta1-42 is due to an interplay between these two Alzheimer"s peptides, ROS and ANT-1 thiols, use was made of mersalyl, a reversible alkylating agent of thiol groups that are oriented toward the external hydrophilic phase, to selectively block and protect, in a reversible manner, the -SH groups of ANT-1.	Sulfhydryl Compounds	191-196	solute carrier family 25 member 4	Homo sapiens	32-65
23583906-1	2013	To find out whether and how the adenine nucleotide translocator-1 (ANT-1) inhibition due to NH2htau and Abeta1-42 is due to an interplay between these two Alzheimer"s peptides, ROS and ANT-1 thiols, use was made of mersalyl, a reversible alkylating agent of thiol groups that are oriented toward the external hydrophilic phase, to selectively block and protect, in a reversible manner, the -SH groups of ANT-1.	Sulfhydryl Compounds	191-196	solute carrier family 25 member 4	Homo sapiens	67-72
23583906-3	2013	We found that the mitochondrial superoxide anions, whose production is induced at the level of Complex I by externally added Abeta1-42 and whose release from mitochondria is significantly reduced by the addition of the VDAC inhibitor DIDS, modify the thiol group/s present at the active site of mitochondrial ANT-1, impair ANT-1 in a mersalyl-prevented manner and abrogate the toxic effect of NH2htau on ANT-1 when Abeta1-42 is already present.	Sulfhydryl Compounds	251-256	solute carrier family 25 member 4	Homo sapiens	309-314
23583906-3	2013	We found that the mitochondrial superoxide anions, whose production is induced at the level of Complex I by externally added Abeta1-42 and whose release from mitochondria is significantly reduced by the addition of the VDAC inhibitor DIDS, modify the thiol group/s present at the active site of mitochondrial ANT-1, impair ANT-1 in a mersalyl-prevented manner and abrogate the toxic effect of NH2htau on ANT-1 when Abeta1-42 is already present.	Sulfhydryl Compounds	251-256	solute carrier family 25 member 4	Homo sapiens	323-328
23583906-3	2013	We found that the mitochondrial superoxide anions, whose production is induced at the level of Complex I by externally added Abeta1-42 and whose release from mitochondria is significantly reduced by the addition of the VDAC inhibitor DIDS, modify the thiol group/s present at the active site of mitochondrial ANT-1, impair ANT-1 in a mersalyl-prevented manner and abrogate the toxic effect of NH2htau on ANT-1 when Abeta1-42 is already present.	Sulfhydryl Compounds	251-256	solute carrier family 25 member 4	Homo sapiens	323-328
23583906-4	2013	A molecular mechanism is proposed in which the pathological Abeta-NH2htau interplay on ANT-1 in Alzheimer"s neurons involves the thiol redox state of ANT-1 and the Abeta1-42-induced ROS increase.	Sulfhydryl Compounds	129-134	solute carrier family 25 member 4	Homo sapiens	87-92
23583906-4	2013	A molecular mechanism is proposed in which the pathological Abeta-NH2htau interplay on ANT-1 in Alzheimer"s neurons involves the thiol redox state of ANT-1 and the Abeta1-42-induced ROS increase.	Sulfhydryl Compounds	129-134	solute carrier family 25 member 4	Homo sapiens	150-155
23615222-1	2013	Thioredoxin (Trx) is a key player in redox homeostasis in various cells, modulating the functions of target proteins by catalyzing a thiol-disulfide exchange reaction.	Sulfhydryl Compounds	133-138	thioredoxin H-type 1	Arabidopsis thaliana	13-16
23525969-1	2013	The thiol reagent N-ethylmaleimide (NEM) is known to inhibit irreversibly ligand binding by the norepinephrine transporter (NET), while the simultaneous presence of NET substrates or ligands protects from this inhibition.	Sulfhydryl Compounds	4-9	solute carrier family 6 member 2	Homo sapiens	96-122
23499836-8	2013	Furthermore, we found that the content of free thiols (the number of reduced cysteines) in RyR2 in cardiomyocytes determined by the monobromobimane fluorescence of RyR2 was decreased markedly in burn-traumatized hearts.	Sulfhydryl Compounds	47-53	ryanodine receptor 2	Homo sapiens	91-95
23499836-8	2013	Furthermore, we found that the content of free thiols (the number of reduced cysteines) in RyR2 in cardiomyocytes determined by the monobromobimane fluorescence of RyR2 was decreased markedly in burn-traumatized hearts.	Sulfhydryl Compounds	47-53	ryanodine receptor 2	Homo sapiens	164-168
23499836-9	2013	Polydatin treatment decreased intracellular reactive oxygen species levels and restored the amount of free thiols in RyR2 in burns.	Sulfhydryl Compounds	107-113	ryanodine receptor 2	Homo sapiens	117-121
23536494-13	2013	Mechanistically, the beneficial effects of genistein appear to be mediated by enhanced eNOS phosphorylation/activation and nitric oxide (NO)-mediated thiol modification of Keap1, with subsequent upregulation of the Nrf2/HO-1 antioxidative signaling pathway and a resultant attenuation of oxidative stress.	Sulfhydryl Compounds	150-155	Kelch-like ECH-associated protein 1	Rattus norvegicus	172-177
25309103-3	2013	Further, the hydrogel enabled the encapsulation and release of a model protein, bovine serum albumin (BSA), over 7 days with ~ 90% released at 48 h. This study serves as a proof-of-concept for the creation of hydrolytically degradable, PEG-ester-thiol-based hydrogels by a photoinitiated step growth mechanism for protein release.	Sulfhydryl Compounds	246-251	albumin	Homo sapiens	87-100
23525969-1	2013	The thiol reagent N-ethylmaleimide (NEM) is known to inhibit irreversibly ligand binding by the norepinephrine transporter (NET), while the simultaneous presence of NET substrates or ligands protects from this inhibition.	Sulfhydryl Compounds	4-9	solute carrier family 6 member 2	Homo sapiens	124-127
23504664-7	2013	Based on the virtual screening and on the results obtained above, the activity may be due to their capacity to reduce the NO synthesis by blocking the bind of L-Arg in the active site of iNOS, the compounds binding the synthase by hydrogen bonds between the NH (2 and/or 4) of thiosemicarbazide fragment (Th-2-8) or N2/N3 from azole cycles and by the thiol function (Th-9-22).	Sulfhydryl Compounds	351-356	nitric oxide synthase 2	Homo sapiens	187-191
23806332-2	2013	(2013) show that a pH-induced conformational change in the quality control protein ERp44 allows retrieval of secretory proteins that contain free thiols via a disulfide linkage from postendoplasmic reticulum compartments to prevent their premature secretion.	Sulfhydryl Compounds	146-152	endoplasmic reticulum protein 44	Homo sapiens	83-88
23603447-2	2013	Recently, we have identified the thiol-dependent cysteine-protease cathepsin B as a novel UVA-target undergoing photo-oxidative inactivation upstream of autophagic-lysosomal dysfunction in fibroblasts.	Sulfhydryl Compounds	33-38	cathepsin B	Homo sapiens	67-78
23755229-10	2013	SIRT1 free thiol (reduced sulfhydryl) content and deacetylase activity are diminished in all examined tissues of APE1/Ref-1(+/-) mice, including the vasculature.	Sulfhydryl Compounds	11-16	sirtuin 1	Mus musculus	0-5
23755229-10	2013	SIRT1 free thiol (reduced sulfhydryl) content and deacetylase activity are diminished in all examined tissues of APE1/Ref-1(+/-) mice, including the vasculature.	Sulfhydryl Compounds	11-16	apurinic/apyrimidinic endonuclease 1	Mus musculus	118-123
23755229-10	2013	SIRT1 free thiol (reduced sulfhydryl) content and deacetylase activity are diminished in all examined tissues of APE1/Ref-1(+/-) mice, including the vasculature.	Sulfhydryl Compounds	26-36	sirtuin 1	Mus musculus	0-5
24427541-7	2013	Images acquired with atomic force microscopy (AFM) disclose that fibrinogen attached primarily to the surface areas presenting thiol head groups, which were surrounded by PEG-silane.	Sulfhydryl Compounds	127-132	fibrinogen beta chain	Homo sapiens	65-75
23755229-4	2013	APE1/Ref-1 maintains sulfhydryl (thiol) groups of cysteine residues in SIRT1 in the reduced form and promotes endothelial SIRT1 activity.	Sulfhydryl Compounds	33-38	apurinic/apyrimidinic endonuclease 1	Mus musculus	5-10
23755229-4	2013	APE1/Ref-1 maintains sulfhydryl (thiol) groups of cysteine residues in SIRT1 in the reduced form and promotes endothelial SIRT1 activity.	Sulfhydryl Compounds	33-38	sirtuin 1	Mus musculus	71-76
23755229-4	2013	APE1/Ref-1 maintains sulfhydryl (thiol) groups of cysteine residues in SIRT1 in the reduced form and promotes endothelial SIRT1 activity.	Sulfhydryl Compounds	33-38	sirtuin 1	Mus musculus	122-127
23755229-5	2013	APE1/Ref-1 stimulates SIRT1 activity by targeting highly conserved vicinal thiols 371 and 374 which form a zinc tetra-thiolate motif in the deacetylase domain of SIRT1.	Sulfhydryl Compounds	75-81	apurinic/apyrimidinic endonuclease 1	Mus musculus	5-10
23755229-5	2013	APE1/Ref-1 stimulates SIRT1 activity by targeting highly conserved vicinal thiols 371 and 374 which form a zinc tetra-thiolate motif in the deacetylase domain of SIRT1.	Sulfhydryl Compounds	75-81	sirtuin 1	Mus musculus	22-27
23755229-5	2013	APE1/Ref-1 stimulates SIRT1 activity by targeting highly conserved vicinal thiols 371 and 374 which form a zinc tetra-thiolate motif in the deacetylase domain of SIRT1.	Sulfhydryl Compounds	75-81	sirtuin 1	Mus musculus	162-167
23724895-7	2013	Furthermore, nitrosylation studies with S-nitrosocysteine followed by immunoblotting with anti SNO-cysteine demonstrated a novel and biologically relevant post translational modification of thiols of CYB5A in HCC specimens only.	Sulfhydryl Compounds	190-196	cytochrome b5 type A	Homo sapiens	200-205
23703906-6	2013	Treatment with the sulphydryl anti-oxidant N-acetylcysteine reversed the abnormalities in the Miner1 deficient cells, suggesting that sulphydryl reducing agents should be explored as a treatment for this rare genetic disease.	Sulfhydryl Compounds	19-29	CDGSH iron sulfur domain 2	Mus musculus	94-100
23703906-6	2013	Treatment with the sulphydryl anti-oxidant N-acetylcysteine reversed the abnormalities in the Miner1 deficient cells, suggesting that sulphydryl reducing agents should be explored as a treatment for this rare genetic disease.	Sulfhydryl Compounds	134-144	CDGSH iron sulfur domain 2	Mus musculus	94-100
23597308-2	2013	In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor.	Sulfhydryl Compounds	215-220	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
22299579-11	2013	CONCLUSION: The inhibition of GRX-1 by 2-AAPA could be used as a tool to study thiol redox state.	Sulfhydryl Compounds	79-84	glutaredoxin	Homo sapiens	30-35
23446148-4	2013	Firstly, the cytokine-stimulating activity of HMGB1 requires C23 and C45 to be in a disulfide linkage, at the same time that C106 must remain in its reduced form as a thiol.	Sulfhydryl Compounds	167-172	high mobility group box 1	Homo sapiens	46-51
23446148-7	2013	This all-thiol HMGB1 exerts its chemotactic activity to initiate inflammation by forming a heterocomplex with CXCL12; that complex binds exclusively to CXCR4 to initiate chemotaxis.	Sulfhydryl Compounds	9-14	high mobility group box 1	Homo sapiens	15-20
23446148-7	2013	This all-thiol HMGB1 exerts its chemotactic activity to initiate inflammation by forming a heterocomplex with CXCL12; that complex binds exclusively to CXCR4 to initiate chemotaxis.	Sulfhydryl Compounds	9-14	C-X-C motif chemokine ligand 12	Homo sapiens	110-116
23446148-7	2013	This all-thiol HMGB1 exerts its chemotactic activity to initiate inflammation by forming a heterocomplex with CXCL12; that complex binds exclusively to CXCR4 to initiate chemotaxis.	Sulfhydryl Compounds	9-14	C-X-C motif chemokine receptor 4	Homo sapiens	152-157
23210597-7	2013	While most attention on glutathione functions in biotic stress responses has been focused on the thiol-regulated protein NPR1, a comparison of JA-linked gene expression in cat2 cad2 and cat2 npr1 double mutants provides evidence that glutathione acts through other components to regulate the response of this pathway to oxidative stress.	Sulfhydryl Compounds	97-102	natriuretic peptide receptor 1	Homo sapiens	121-125
23575993-14	2013	In TRAMP tumor, mercury orange staining demonstrated increased thiols.	Sulfhydryl Compounds	63-69	tumor necrosis factor receptor superfamily, member 25	Mus musculus	3-8
23532321-8	2013	The three cysteine residues of HSP60 exhibit different responses to gossypol treatment: an increase of thiol/disulfide ratio for the Cys447 residue due to a decrease of the cellular GSH level, and a decrease of thiol/disulfide ratios for Cys442 and Cys237 residues due to oxidation and sulfation.	Sulfhydryl Compounds	103-108	heat shock protein family D (Hsp60) member 1	Homo sapiens	31-36
23532321-8	2013	The three cysteine residues of HSP60 exhibit different responses to gossypol treatment: an increase of thiol/disulfide ratio for the Cys447 residue due to a decrease of the cellular GSH level, and a decrease of thiol/disulfide ratios for Cys442 and Cys237 residues due to oxidation and sulfation.	Sulfhydryl Compounds	211-216	heat shock protein family D (Hsp60) member 1	Homo sapiens	31-36
23597308-2	2013	In this method, the AChE molecules catalyzed the hydrolysis of acetylthiocholine (ATCl) to form thiocholine, which in turn can specifically react with fluorescent squaraine derivative, a specific chemodosimeter for thiol-containing compounds, resulting in fluorescence quenching and offering a low fluorometric background for the further detection of AChE inhibitor.	Sulfhydryl Compounds	215-220	acetylcholinesterase (Cartwright blood group)	Homo sapiens	351-355
23244636-4	2013	Increased expression of p22(phox) and Nox4 in PPHN lungs, PA, and PASMC was associated with increased reactive oxygen species in PPHN PA, increased protein thiol oxidation in PPHN PASMC, and a decreased activity of extracellular superoxide dismutase (ecSOD) in the lungs and PASMC.	Sulfhydryl Compounds	156-161	NADPH oxidase 4	Ovis aries	38-42
23543738-9	2013	Although the sulfenic acid forms of Prx2 and Prx3 are ~1000-fold less reactive with H2O2 than their active site thiols, they react several orders of magnitude faster than most reduced thiol proteins.	Sulfhydryl Compounds	112-118	peroxiredoxin 2	Homo sapiens	36-40
23543738-9	2013	Although the sulfenic acid forms of Prx2 and Prx3 are ~1000-fold less reactive with H2O2 than their active site thiols, they react several orders of magnitude faster than most reduced thiol proteins.	Sulfhydryl Compounds	112-117	peroxiredoxin 2	Homo sapiens	36-40
23501724-4	2013	The thiol-terminated aptamer is first immobilized on AuNPs/graphene modified electrode, and then thrombin is imported to form the aptamer-thrombin complexes.	Sulfhydryl Compounds	4-9	coagulation factor II, thrombin	Homo sapiens	97-105
23501724-4	2013	The thiol-terminated aptamer is first immobilized on AuNPs/graphene modified electrode, and then thrombin is imported to form the aptamer-thrombin complexes.	Sulfhydryl Compounds	4-9	coagulation factor II, thrombin	Homo sapiens	138-146
23244636-5	2013	Nox4 small interfering RNA (siRNA) decreased Nox4 expression and thiol oxidation and increased the ecSOD activity in PPHN PASMC.	Sulfhydryl Compounds	65-70	NADPH oxidase 4	Ovis aries	0-4
23583403-6	2013	The inhibitory effect of SFN on the interaction of LPS and MD2 was reversed by thiol supplementation with N-acetyl-L-cysteine or dithiothreitol showing that the inhibitory effect of SFN is dependent on its thiol-modifying activity.	Sulfhydryl Compounds	79-84	lymphocyte antigen 96	Homo sapiens	59-62
23025503-4	2013	Remarkably, by simultaneously triggering slow disulfide bond formation and the buildup of H(2)O(2), the lack of PRDX4 and endoplasmic oxidoreductin 1 (ERO1) exposes the thiols of new client proteins to competing H(2)O(2)-mediated oxidation, which leads to an increase in sulfenylated proteins.	Sulfhydryl Compounds	169-175	peroxiredoxin 4	Mus musculus	112-117
23583403-6	2013	The inhibitory effect of SFN on the interaction of LPS and MD2 was reversed by thiol supplementation with N-acetyl-L-cysteine or dithiothreitol showing that the inhibitory effect of SFN is dependent on its thiol-modifying activity.	Sulfhydryl Compounds	206-211	lymphocyte antigen 96	Homo sapiens	59-62
23660853-0	2013	beta2-integrin activity: the role of thiols.	Sulfhydryl Compounds	37-43	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-5
23486473-6	2013	In situ equilibrium redox titrations and thiol redox-sensitive labeling studies showed that the gamma subunit disulfide/sulfhydryl couple in the modified ATP synthase has a more reducing redox potential and thus remains predominantly oxidized under physiological conditions, implying that the highly conserved acidic residues in the gamma subunit influence thiol redox potential.	Sulfhydryl Compounds	41-46	ATP synthase	Arabidopsis thaliana	154-166
23486473-6	2013	In situ equilibrium redox titrations and thiol redox-sensitive labeling studies showed that the gamma subunit disulfide/sulfhydryl couple in the modified ATP synthase has a more reducing redox potential and thus remains predominantly oxidized under physiological conditions, implying that the highly conserved acidic residues in the gamma subunit influence thiol redox potential.	Sulfhydryl Compounds	357-362	ATP synthase	Arabidopsis thaliana	154-166
23121505-3	2013	It has been long proposed that the thioredoxin (Trx) system, which consists of Trx and thioredoxin reductase (Trr), is not only involved in recycling classical Trx substrates, such as ribonucleotide reductase, but it also regulates general cytoplasmic thiol homeostasis.	Sulfhydryl Compounds	252-257	thioredoxin	Homo sapiens	35-46
23231445-1	2013	SIGNIFICANCE: Glutaredoxins (Grxs) are small oxidoreductases of the thioredoxin family of proteins regulating the thiol redox state of several proteins.	Sulfhydryl Compounds	114-119	thioredoxin	Homo sapiens	68-79
23396001-1	2013	BACKGROUND: Trypanosomatids are early-diverging eukaryotes devoid of the major disulfide reductases - glutathione reductase and thioredoxin reductase - that control thiol-redox homeostasis in most organisms.	Sulfhydryl Compounds	165-170	glutathione-disulfide reductase	Homo sapiens	102-123
23244515-7	2013	Central to redox signaling processes are the glutathione and thioredoxin systems controlling H(2)O(2) levels and, hence, the thiol/disulfide balance.	Sulfhydryl Compounds	125-130	thioredoxin	Homo sapiens	61-72
23121505-3	2013	It has been long proposed that the thioredoxin (Trx) system, which consists of Trx and thioredoxin reductase (Trr), is not only involved in recycling classical Trx substrates, such as ribonucleotide reductase, but it also regulates general cytoplasmic thiol homeostasis.	Sulfhydryl Compounds	252-257	thioredoxin	Homo sapiens	48-51
23121505-3	2013	It has been long proposed that the thioredoxin (Trx) system, which consists of Trx and thioredoxin reductase (Trr), is not only involved in recycling classical Trx substrates, such as ribonucleotide reductase, but it also regulates general cytoplasmic thiol homeostasis.	Sulfhydryl Compounds	252-257	thioredoxin	Homo sapiens	79-82
23121505-3	2013	It has been long proposed that the thioredoxin (Trx) system, which consists of Trx and thioredoxin reductase (Trr), is not only involved in recycling classical Trx substrates, such as ribonucleotide reductase, but it also regulates general cytoplasmic thiol homeostasis.	Sulfhydryl Compounds	252-257	peroxiredoxin 5	Homo sapiens	87-108
23121505-3	2013	It has been long proposed that the thioredoxin (Trx) system, which consists of Trx and thioredoxin reductase (Trr), is not only involved in recycling classical Trx substrates, such as ribonucleotide reductase, but it also regulates general cytoplasmic thiol homeostasis.	Sulfhydryl Compounds	252-257	peroxiredoxin 5	Homo sapiens	110-113
23121505-3	2013	It has been long proposed that the thioredoxin (Trx) system, which consists of Trx and thioredoxin reductase (Trr), is not only involved in recycling classical Trx substrates, such as ribonucleotide reductase, but it also regulates general cytoplasmic thiol homeostasis.	Sulfhydryl Compounds	252-257	thioredoxin	Homo sapiens	79-82
23121505-7	2013	A massive thiol oxidation occurs only in cells lacking Trr, with 30% of all cysteine-containing peptides being reversibly oxidized; this oxidized cysteine proteome depends on the presence of Trxs.	Sulfhydryl Compounds	10-15	peroxiredoxin 5	Homo sapiens	55-58
23121505-8	2013	Our observations lead to the hypothesis that, in the absence of its reductase, the natural electron donor Trx becomes a powerful oxidant and triggers general thiol oxidation.	Sulfhydryl Compounds	158-163	thioredoxin	Homo sapiens	106-109
23396001-1	2013	BACKGROUND: Trypanosomatids are early-diverging eukaryotes devoid of the major disulfide reductases - glutathione reductase and thioredoxin reductase - that control thiol-redox homeostasis in most organisms.	Sulfhydryl Compounds	165-170	peroxiredoxin 5	Homo sapiens	128-149
23606429-2	2013	This protein contrast agent was obtained by attaching the thiol-reactive Gd[MTS-ADO3A] label at Cys residues replaced at four distinct positions (52, 55, 76 and 80) in apoA-I.	Sulfhydryl Compounds	58-63	apolipoprotein A-I	Mus musculus	168-174
23354308-0	2013	Degradation of NF-kappaB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells.	Sulfhydryl Compounds	79-84	tumor protein p53	Homo sapiens	26-29
23472850-11	2013	Thus, NGF plays a critical role in liver protection against oxidative stress and xenobiotic injury as well as maintains a reduced thiol state.	Sulfhydryl Compounds	130-135	nerve growth factor	Mus musculus	6-9
23527630-1	2013	Nanoparticles functionalized with mixed self-assembled monolayers (m-SAMs) comprising positively and negatively charged thiols are stable at both low and high pH but precipitate sharply at the pH where the charges on the particle are balanced (pH(prec)).	Sulfhydryl Compounds	120-126	methionine adenosyltransferase 1A	Homo sapiens	69-73
23648861-0	2013	Effect of mild-thiol reducing agents and alpha2,3-sialyltransferase expression on secretion and sialylation of recombinant EPO in CHO cells.	Sulfhydryl Compounds	15-20	erythropoietin	Cricetulus griseus	123-126
23501101-6	2013	In this work we report for the first time the redox sensitivity of p63 and p73 core domains to a thiol oxidizing agent azodicarboxylic acid bis[dimethylamide] (diamide).	Sulfhydryl Compounds	97-102	tumor protein p63	Homo sapiens	67-70
23648861-4	2013	A pulse-chase study of EPO secretion revealed that all four thiol-reducing agents increased the EPO secretion rate; among them TLA showed the highest rate.	Sulfhydryl Compounds	60-65	erythropoietin	Cricetulus griseus	23-26
23648861-4	2013	A pulse-chase study of EPO secretion revealed that all four thiol-reducing agents increased the EPO secretion rate; among them TLA showed the highest rate.	Sulfhydryl Compounds	60-65	erythropoietin	Cricetulus griseus	96-99
23447529-5	2013	In this approach, salt-free lyophilized (15)N-labeled all-thiol HMGB1 was dissolved in actual extracellular fluids, and the oxidation and clearance kinetics were monitored in situ by recording a series of heteronuclear (1)H-(15)N correlation spectra.	Sulfhydryl Compounds	58-63	high mobility group box 1	Homo sapiens	64-69
23447529-7	2013	For example, the half-life of all-thiol HMGB1 ranged from ~17 min (in human serum and saliva) to 3 h (in prostate cancer cell culture medium).	Sulfhydryl Compounds	34-39	high mobility group box 1	Homo sapiens	40-45
23501101-6	2013	In this work we report for the first time the redox sensitivity of p63 and p73 core domains to a thiol oxidizing agent azodicarboxylic acid bis[dimethylamide] (diamide).	Sulfhydryl Compounds	97-102	tumor protein p73	Homo sapiens	75-78
23282150-1	2013	IP(3)R (IP(3) [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca(2+) channels and both are regulated by thiol reagents.	Sulfhydryl Compounds	166-171	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	0-6
23282150-2	2013	In DT40 cells stably expressing single subtypes of mammalian IP(3)R, low concentrations of thimerosal (also known as thiomersal), which oxidizes thiols to form a thiomercurylethyl complex, increased the sensitivity of IP(3)-evoked Ca(2+) release via IP(3)R1 and IP(3)R2, but inhibited IP(3)R3.	Sulfhydryl Compounds	145-151	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-67
23282150-9	2013	This is the first systematic analysis of the effects of a thiol reagent on each IP(3)R subtype.	Sulfhydryl Compounds	58-63	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	80-86
23386702-1	2013	UNLABELLED: Carboxylesterases hydrolyze esters, amides, and thioesters to produce carboxylic acids and resulting alcohols, amines, and thiols, respectively.	Sulfhydryl Compounds	135-141	carboxylesterase 1	Homo sapiens	12-29
23463512-10	2013	We conclude that thiol isomerases and thiol-disulfide exchange contribute to TGF-beta1 activation and identify a number of molecules that may participate in the process.	Sulfhydryl Compounds	17-22	transforming growth factor beta 1	Homo sapiens	77-86
22607099-1	2013	The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells, maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine dinucleotide phosphate through Trx reductase to Trx, which reduces its target proteins using highly conserved thiol groups.	Sulfhydryl Compounds	290-295	thioredoxin	Homo sapiens	4-15
22607099-1	2013	The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells, maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine dinucleotide phosphate through Trx reductase to Trx, which reduces its target proteins using highly conserved thiol groups.	Sulfhydryl Compounds	290-295	thioredoxin	Homo sapiens	17-20
22607099-1	2013	The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells, maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine dinucleotide phosphate through Trx reductase to Trx, which reduces its target proteins using highly conserved thiol groups.	Sulfhydryl Compounds	290-295	thioredoxin	Homo sapiens	211-214
22607099-1	2013	The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells, maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine dinucleotide phosphate through Trx reductase to Trx, which reduces its target proteins using highly conserved thiol groups.	Sulfhydryl Compounds	290-295	thioredoxin	Homo sapiens	211-214
22978553-6	2013	Endogenous thiol antioxidants glutathione and thioredoxin are modulated with high oxygen consumption and ROS generation during physical exercise, controlling cellular function through redox-sensitive signaling and protein-protein interactions.	Sulfhydryl Compounds	11-16	thioredoxin	Homo sapiens	46-57
23239746-1	2013	Peroxiredoxin (Prx) 1 is a member of the thiol-specific peroxidases family and plays diverse roles such as H2O2 scavenger, redox signal transducer and molecular chaperone.	Sulfhydryl Compounds	41-46	peroxiredoxin 1	Homo sapiens	0-21
23239345-2	2013	Thioredoxin-1 (Trx-1) plays important biological roles both in intra- and extracellular compartments, including in regulation of various intracellular molecules via thiol redox control.	Sulfhydryl Compounds	165-170	thioredoxin 1	Rattus norvegicus	0-13
23239345-2	2013	Thioredoxin-1 (Trx-1) plays important biological roles both in intra- and extracellular compartments, including in regulation of various intracellular molecules via thiol redox control.	Sulfhydryl Compounds	165-170	thioredoxin 1	Rattus norvegicus	15-20
23341578-8	2013	Because fluorescent labelling of GR protein thiols showed lower amounts of reduced thiols after exercise, we sought to determine the source of intracellular reactive oxygen species that may be activating GR.	Sulfhydryl Compounds	44-50	glutathione-disulfide reductase	Rattus norvegicus	33-35
23341578-8	2013	Because fluorescent labelling of GR protein thiols showed lower amounts of reduced thiols after exercise, we sought to determine the source of intracellular reactive oxygen species that may be activating GR.	Sulfhydryl Compounds	83-89	glutathione-disulfide reductase	Rattus norvegicus	33-35
23341578-11	2013	These changes correlated with thiol-dependent modifications of GR.	Sulfhydryl Compounds	30-35	glutathione-disulfide reductase	Rattus norvegicus	63-65
23400900-1	2013	BACKGROUND AND OBJECTIVE: Dalcetrapib, a cholesteryl ester transfer protein (CETP) modulator, is a thioester pro-drug that is rapidly hydrolysed to generate a pharmacologically active thiol.	Sulfhydryl Compounds	184-189	cholesteryl ester transfer protein	Homo sapiens	41-75
23400900-1	2013	BACKGROUND AND OBJECTIVE: Dalcetrapib, a cholesteryl ester transfer protein (CETP) modulator, is a thioester pro-drug that is rapidly hydrolysed to generate a pharmacologically active thiol.	Sulfhydryl Compounds	184-189	cholesteryl ester transfer protein	Homo sapiens	77-81
23499690-10	2013	Thus, pretreatment with the thiol antioxidants NAC and GSH abrogated the killing activity of sanguinarine.	Sulfhydryl Compounds	28-33	X-linked Kx blood group	Homo sapiens	47-50
23454639-3	2013	Using an amine- and sulfhydryl-reactive crosslinker of 6.8A length (SPDP) we found that in the D-form of complex I the ND3 subunit crosslinked to the 39 kDa (NDUFA9) subunit.	Sulfhydryl Compounds	20-30	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	119-122
23454639-3	2013	Using an amine- and sulfhydryl-reactive crosslinker of 6.8A length (SPDP) we found that in the D-form of complex I the ND3 subunit crosslinked to the 39 kDa (NDUFA9) subunit.	Sulfhydryl Compounds	20-30	NADH:ubiquinone oxidoreductase subunit A9	Homo sapiens	158-164
23549272-6	2013	The protein thiol section focuses on glutaredoxins and thioredoxins, proteins with oxidoreductase activity, which are involved in protein glutathionylation.	Sulfhydryl Compounds	12-17	thioredoxin reductase 1	Homo sapiens	83-97
23315166-6	2013	Blockade of free thiols, an inhibitory monoclonal antibody to protein disulfide isomerase (PDI), and the small-molecule PDI antagonist quercetin-3-rutinoside prevented ATG-mediated TF activation, and C5 complement activation resulted in oxidation of cell surface PDI.	Sulfhydryl Compounds	17-23	prolyl 4-hydroxylase subunit beta	Homo sapiens	62-89
24124425-10	2013	In GHD patients, serum MDA level was negatively correlated with serum HDL-cholesterol (r = -0.499, P = 0.001), and serum PON1 activity was positively correlated with serum thiol and HDL-cholesterol levels (r = 0.306, P = 0.032 and r = 0.303, P = 0.033, respectively).	Sulfhydryl Compounds	172-177	paraoxonase 1	Homo sapiens	121-125
23315166-7	2013	This rapid and potent mechanism of cellular TF activation represents a novel connection between the complement system and cell surface PDI-mediated thiol-disulfide exchange.	Sulfhydryl Compounds	148-153	prolyl 4-hydroxylase subunit beta	Homo sapiens	135-138
23376332-2	2013	Results showed that Ru2azo could selectively and effectively react with biological thiols (such as cysteine, homocysteine and glutathione) with a 10(-7)M detection limit.	Sulfhydryl Compounds	83-89	doublecortin domain containing 2	Homo sapiens	20-23
23376332-3	2013	After it reacted with thiols, the original gray color of Ru2azo solution immediately turned yellow and the luminescence significantly enhanced, showing "naked-eye" colorimetric and "off-on" luminescent dual-signaling response for thiols.	Sulfhydryl Compounds	22-28	doublecortin domain containing 2	Homo sapiens	57-60
23376332-3	2013	After it reacted with thiols, the original gray color of Ru2azo solution immediately turned yellow and the luminescence significantly enhanced, showing "naked-eye" colorimetric and "off-on" luminescent dual-signaling response for thiols.	Sulfhydryl Compounds	230-236	doublecortin domain containing 2	Homo sapiens	57-60
23376332-4	2013	Mechanism studies demonstrated that Ru2azo reacted with thiols undergoing a two-electron transfer process, forming the azo(2-) anion product.	Sulfhydryl Compounds	56-62	doublecortin domain containing 2	Homo sapiens	36-39
23306136-5	2013	[(18)F]FBA was used for the synthesis of novel thiol-reactive prosthetic group 4-[(18)F]fluorobenzyl)maleimide [(18)F]FBM and Hsp90 inhibitor 17-(4-[(18)F]fluorobenzylamino)-17-demethoxy-geldanamycin [(18)F] GA.	Sulfhydryl Compounds	47-52	heat shock protein 90 alpha family class A member 1	Homo sapiens	126-131
23047022-6	2013	In an effort to understand the shedding process of AChE, we have used several pharmacological treatments, which showed that it is likely to be mediated in part by an EDTA- and batimastat-sensitive, but GM6001-insensitive metalloprotease, with the possible additional involvement of a thiol isomerase.	Sulfhydryl Compounds	284-289	acetylcholinesterase	Mus musculus	51-55
23401229-2	2013	Key steps of the syntheses of the sulfanes are the photochemical trifluoromethylation of the thiols with CF3 Hal (Hal=halide) or substitution of alkoxyphosphinediamines with CF3 SSCF3 .	Sulfhydryl Compounds	93-99	histidine ammonia-lyase	Homo sapiens	109-112
23516120-11	2013	Targets of Trx, such as phosphoribulokinase, glyceraldehyde-3-phosphate dehydrogenase, transketolase, and sedoheptulose-1,7-bisphosphatase have at least one regulatory disulfide bridge which supports the conclusion that the identified proteins undergo reversible thiol oxidation.	Sulfhydryl Compounds	263-268	thioredoxin	Homo sapiens	11-14
23360541-7	2013	Thiolated siRNA targeting glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was directly conjugated to the polymeric micelles via thiol exchange reactions with the pyridal disulfide groups present in the micelle corona.	Sulfhydryl Compounds	129-134	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	26-66
23360541-7	2013	Thiolated siRNA targeting glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was directly conjugated to the polymeric micelles via thiol exchange reactions with the pyridal disulfide groups present in the micelle corona.	Sulfhydryl Compounds	129-134	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	68-73
23401229-2	2013	Key steps of the syntheses of the sulfanes are the photochemical trifluoromethylation of the thiols with CF3 Hal (Hal=halide) or substitution of alkoxyphosphinediamines with CF3 SSCF3 .	Sulfhydryl Compounds	93-99	histidine ammonia-lyase	Homo sapiens	114-117
23388070-3	2013	The porous surfaces coated with Group VIII and IB nanocrystals (such as Fe, Co, Ni, Cu, and Ag) can not only present multiscale surface roughness, but also readily coordinate with thiols, leading to special wettability.	Sulfhydryl Compounds	180-186	cytochrome c oxidase subunit 8A	Homo sapiens	38-42
23507749-8	2013	The total thiol assay, which is based on a completely different principle, showed a good and statistically significant correlation with the BAP assay (0.510) and also to the TAS assay, but to a lower and not significant extent (0.279) and not with the FRAP assay (-0.008).	Sulfhydryl Compounds	10-15	mechanistic target of rapamycin kinase	Homo sapiens	252-256
23246566-15	2013	To our knowledge, this is the first study showing that MnSOD activity can be reversibly regulated in vivo, through a mechanism involving thiol residues.	Sulfhydryl Compounds	137-142	superoxide dismutase 2	Rattus norvegicus	55-60
23212077-7	2013	The Cys73 of S-nitrosylated Trx1 is responsible for its transnitrosylating activity whereas the free thiol in Cys32 of Trx1 for its denitrosylating activity.	Sulfhydryl Compounds	101-106	thioredoxin	Homo sapiens	28-32
23212077-7	2013	The Cys73 of S-nitrosylated Trx1 is responsible for its transnitrosylating activity whereas the free thiol in Cys32 of Trx1 for its denitrosylating activity.	Sulfhydryl Compounds	101-106	thioredoxin	Homo sapiens	119-123
23356510-2	2013	New understanding of thiol-disulfide systems have occurred during the past decade as a consequence of the discoveries that thiol and disulfide systems are maintained in kinetically controlled steady states displaced from thermodynamic equilibrium, that a widely distributed family of NADPH oxidases produces oxidants that function in cell signaling and that a family of peroxiredoxins utilize thioredoxin as a reductant to complement the well-studied glutathione antioxidant system for peroxide elimination and redox regulation.	Sulfhydryl Compounds	21-26	thioredoxin	Homo sapiens	393-404
23356510-2	2013	New understanding of thiol-disulfide systems have occurred during the past decade as a consequence of the discoveries that thiol and disulfide systems are maintained in kinetically controlled steady states displaced from thermodynamic equilibrium, that a widely distributed family of NADPH oxidases produces oxidants that function in cell signaling and that a family of peroxiredoxins utilize thioredoxin as a reductant to complement the well-studied glutathione antioxidant system for peroxide elimination and redox regulation.	Sulfhydryl Compounds	123-128	thioredoxin	Homo sapiens	393-404
23169585-8	2013	This interaction and others are absent in the unfolded Atx1s and the two Cys ligands have pK(a) values reminiscent of free thiols (&gt;8) resulting in lowered Cu(I) affinities at pH 7.	Sulfhydryl Compounds	123-129	antioxidant 1 copper chaperone	Homo sapiens	55-59
23402628-1	2013	Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them.	Sulfhydryl Compounds	59-64	lysozyme	Homo sapiens	156-164
23402628-1	2013	Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them.	Sulfhydryl Compounds	59-64	fibrinogen beta chain	Homo sapiens	169-179
23709379-8	2013	RESULTS: PON1 arylesterase activity decreased in general and central obesity, high blood pressure, and hyperinsulinemia conditions and correlated with BMI, CRP, adipocyte fatty acid-binding protein, superoxide dismutase, catalase, glutathione peroxidase, free thiols, and HOMA in a gender-dependent manner.	Sulfhydryl Compounds	260-266	paraoxonase 1	Homo sapiens	9-13
23291859-3	2013	RESULTS: In SMP30 KO mice, 5-HT-induced vasoconstriction occurred, which altered vasodilation with dithiothreitol, a thiol-reducing agent.	Sulfhydryl Compounds	117-122	regucalcin	Mus musculus	12-17
23292796-10	2013	Other FDA-approved thiol-reactive compounds were at least 1000-fold less potent than fursultiamine in antagonizing hepcidin.	Sulfhydryl Compounds	19-24	hepcidin antimicrobial peptide	Homo sapiens	115-123
23065353-8	2013	We report here that DJ-1-overexpressing astrocytes were significantly more protective against rotenone-induced neuronal thiol oxidation than wild-type astrocytes in neuron-astrocyte cocultures.	Sulfhydryl Compounds	120-125	Parkinsonism associated deglycase	Homo sapiens	20-24
23065353-9	2013	DJ-1-knockdown astrocytes, on the other hand, were significantly impaired in their capacity to protect neurons against thiol oxidation.	Sulfhydryl Compounds	119-124	Parkinsonism associated deglycase	Homo sapiens	0-4
23292796-7	2013	Fursultiamine directly interfered with hepcidin binding to its receptor, ferroportin, by blocking ferroportin C326 thiol residue essential for hepcidin binding.	Sulfhydryl Compounds	115-120	hepcidin antimicrobial peptide	Homo sapiens	39-47
23292796-7	2013	Fursultiamine directly interfered with hepcidin binding to its receptor, ferroportin, by blocking ferroportin C326 thiol residue essential for hepcidin binding.	Sulfhydryl Compounds	115-120	hepcidin antimicrobial peptide	Homo sapiens	143-151
23362983-4	2013	Studies of its mechanism revealed that GC20 specifically inhibits the enzymatic activity of thioredoxin reductase by binding to selenocysteine residue, without targeting other well-known selenol and thiol groups contained in biomolecules.	Sulfhydryl Compounds	199-204	eukaryotic translation initiation factor 1B	Mus musculus	39-43
23264618-3	2013	A thiol-disulfide status in SOD1 will thus play a regulatory role in determining its folding/misfolding pathways; however, it remains unknown how pathogenic mutations in SOD1 affect the thiol-disulfide status to facilitate the protein misfolding.	Sulfhydryl Compounds	2-7	superoxide dismutase 1	Homo sapiens	28-32
23211187-3	2013	We searched for the conformational species with a similar appearance and found that SH1-SH2 (thiols 1 and 2)-cross-linked myosin is a good candidate.	Sulfhydryl Compounds	93-99	myosin heavy chain 14	Homo sapiens	122-128
23277276-7	2013	We also investigated the effect of Prdx1 silencing on thiol protein oxidation.	Sulfhydryl Compounds	54-59	peroxiredoxin 1	Homo sapiens	35-40
23321307-3	2013	As a proof of concept, we reconstituted the human ABC transporter MRP3 into biotinylated proteoliposomes and tethered those to a gold surface coated with streptavidin on a biotinylated self-assembled thiol monolayer.	Sulfhydryl Compounds	200-205	ATP binding cassette subfamily C member 3	Homo sapiens	66-70
23264618-3	2013	A thiol-disulfide status in SOD1 will thus play a regulatory role in determining its folding/misfolding pathways; however, it remains unknown how pathogenic mutations in SOD1 affect the thiol-disulfide status to facilitate the protein misfolding.	Sulfhydryl Compounds	186-191	superoxide dismutase 1	Homo sapiens	28-32
23264618-3	2013	A thiol-disulfide status in SOD1 will thus play a regulatory role in determining its folding/misfolding pathways; however, it remains unknown how pathogenic mutations in SOD1 affect the thiol-disulfide status to facilitate the protein misfolding.	Sulfhydryl Compounds	186-191	superoxide dismutase 1	Homo sapiens	170-174
23327656-2	2013	Only few extracellular targets of Trx-mediated thiol-disulfide exchange are known.	Sulfhydryl Compounds	47-52	thioredoxin	Homo sapiens	34-37
23149817-2	2013	Ruthenium complexes of the type (p-cymene)(NHC)RuCl(2) interacted with biologically relevant thiols and selenols, which resulted in the inhibition of enzymes such as thioredoxin reductase or cathepsin B.	Sulfhydryl Compounds	93-99	peroxiredoxin 5	Homo sapiens	166-187
23149817-2	2013	Ruthenium complexes of the type (p-cymene)(NHC)RuCl(2) interacted with biologically relevant thiols and selenols, which resulted in the inhibition of enzymes such as thioredoxin reductase or cathepsin B.	Sulfhydryl Compounds	93-99	cathepsin B	Homo sapiens	191-202
23261512-4	2013	The three thiol, carboxyl, and amino binding groups of d-Pen were presumed to interact with Au NP surfaces on the basis of the infrared spectral features.	Sulfhydryl Compounds	10-15	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	57-60
23581983-4	2013	Electrophiles react with critical thiol groups of Keap1 leading to the loss of its ability to inhibit Nrf2.	Sulfhydryl Compounds	34-39	kelch like ECH associated protein 1	Homo sapiens	50-55
23581983-4	2013	Electrophiles react with critical thiol groups of Keap1 leading to the loss of its ability to inhibit Nrf2.	Sulfhydryl Compounds	34-39	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
23223577-0	2013	Thioredoxin and thioredoxin reductase control tissue factor activity by thiol redox-dependent mechanism.	Sulfhydryl Compounds	72-77	thioredoxin	Homo sapiens	0-11
23223577-0	2013	Thioredoxin and thioredoxin reductase control tissue factor activity by thiol redox-dependent mechanism.	Sulfhydryl Compounds	72-77	peroxiredoxin 5	Homo sapiens	16-37
23223577-0	2013	Thioredoxin and thioredoxin reductase control tissue factor activity by thiol redox-dependent mechanism.	Sulfhydryl Compounds	72-77	coagulation factor III, tissue factor	Homo sapiens	46-59
23237540-3	2013	In contrast, amifostine"s free thiol form WR1065 can directly activate NF-kappaB giving rise to elevated SOD2 activity 24 h later and induce an adaptive response in both MEF wild-type and TNF signaling defective TNFR1(-)R2(-) cells.	Sulfhydryl Compounds	31-36	superoxide dismutase 2, mitochondrial	Mus musculus	105-109
23237540-3	2013	In contrast, amifostine"s free thiol form WR1065 can directly activate NF-kappaB giving rise to elevated SOD2 activity 24 h later and induce an adaptive response in both MEF wild-type and TNF signaling defective TNFR1(-)R2(-) cells.	Sulfhydryl Compounds	31-36	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	212-217
23434659-8	2013	In this report, we will review the studies detailing the reactivity of annexin A2 thiols and the importance of these reactive cysteine(s) in regulating annexin A2 structure and function.	Sulfhydryl Compounds	82-88	annexin A2	Homo sapiens	71-81
23486578-1	2013	The extensively used thiol antioxidants (dithiothreitol, glutathione, and N-acetylcysteine) in combination with hydroxycobalamine (vitamin B12) gain toxic activity in relation to human lymphocytic leukemia cell line HL60.	Sulfhydryl Compounds	21-26	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	139-142
23256719-5	2013	Thiol compounts such as N-acetyl-L-cysteine (NAC), carbocysteine, erdosteine, and fudosteine have been extensively studied.	Sulfhydryl Compounds	0-5	X-linked Kx blood group	Homo sapiens	45-48
23205777-10	2013	Additionally, such oxidative modification was shown to be associated with preventing DLDH from further inactivation by the thiol-reactive reagent N-ethylmaleimide.	Sulfhydryl Compounds	123-128	dihydrolipoamide dehydrogenase	Rattus norvegicus	85-89
23325480-8	2013	Thiol-disulfide exchange involving this disulfide is implicated in TF activation with the formation of the disulfide bond corresponding with the active conformation of TF and free thiol or thiol-modified forms corresponding with encryption.	Sulfhydryl Compounds	0-5	coagulation factor III, tissue factor	Homo sapiens	67-69
23325480-8	2013	Thiol-disulfide exchange involving this disulfide is implicated in TF activation with the formation of the disulfide bond corresponding with the active conformation of TF and free thiol or thiol-modified forms corresponding with encryption.	Sulfhydryl Compounds	0-5	coagulation factor III, tissue factor	Homo sapiens	168-170
23325480-8	2013	Thiol-disulfide exchange involving this disulfide is implicated in TF activation with the formation of the disulfide bond corresponding with the active conformation of TF and free thiol or thiol-modified forms corresponding with encryption.	Sulfhydryl Compounds	180-185	coagulation factor III, tissue factor	Homo sapiens	67-69
23325480-8	2013	Thiol-disulfide exchange involving this disulfide is implicated in TF activation with the formation of the disulfide bond corresponding with the active conformation of TF and free thiol or thiol-modified forms corresponding with encryption.	Sulfhydryl Compounds	189-194	coagulation factor III, tissue factor	Homo sapiens	67-69
22926048-3	2013	HEDS is rapidly detoxified in normal glucose but triggered a p53-independent metabolic stress in glucose depleted state that caused loss of NADPH, protein and non-protein thiol homeostasis and Ku function, and enhanced sensitivity of both p53 wild type and mutant cells to radiation induced oxidative stress.	Sulfhydryl Compounds	171-176	tumor protein p53	Homo sapiens	61-64
22746225-3	2013	Here we aim to elucidate the possible role of its human homolog BOLA1 in mitochondrial morphology and thiol redox potential regulation.	Sulfhydryl Compounds	102-107	bolA family member 1	Homo sapiens	64-69
23188057-1	2013	A new bifunctional compound NCC, which undergoes thiol-mediated disulfide cleavage after cell entry, produces a red-shifted fluorescent emission in the cytosol and releases free active DNA alkylating agent CLB into the nucleus, and finally leads to DNA damage and cell death.	Sulfhydryl Compounds	49-54	citramalyl-CoA lyase	Homo sapiens	206-209
23148211-0	2013	Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.	Sulfhydryl Compounds	119-124	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	0-27
23148211-0	2013	Protein-disulfide isomerase regulates the thyroid hormone receptor-mediated gene expression via redox factor-1 through thiol reduction-oxidation.	Sulfhydryl Compounds	119-124	apurinic/apyrimidinic endodeoxyribonuclease 1	Rattus norvegicus	96-110
22883750-3	2013	After immobilizing the thiol-capped anti-human IgE aptamer onto the AuNPs through self-assembly, we treated the electrode with mercaptohexanol (MCH) to ensure that the remaining unoccupied surfaces of the AuNPs would not undergo nonspecific binding.	Sulfhydryl Compounds	23-28	immunoglobulin heavy constant epsilon	Homo sapiens	47-50
22884002-2	2013	The aptasensor was fabricated by co-assembling thiol-modified anti-thrombin binding aptamer, dithiothreitol and mercaptohexanol on the surface of gold electrode.	Sulfhydryl Compounds	47-52	coagulation factor II, thrombin	Homo sapiens	67-75
23199030-4	2013	Through "click" reaction between the maleimide residue on particle surface and thiol group from the partly reduced anti-EGFR monoclonal antibody (mAb), NaGdF(4)-PEG-mAb nanoprobes were constructed, and their biocompatibility and binding specificity were evaluated through in vitro experiments.	Sulfhydryl Compounds	79-84	epidermal growth factor receptor	Mus musculus	120-124
22746225-4	2013	RESULTS: We show that BOLA1 is a mitochondrial protein that counterbalances the effect of L-buthionine-(S,R)-sulfoximine (BSO)-induced glutathione (GSH) depletion on the mitochondrial thiol redox potential.	Sulfhydryl Compounds	184-189	bolA family member 1	Homo sapiens	22-27
22746225-6	2013	Conversely, knockdown of the BOLA1 gene increases the oxidation of mitochondrial thiol groups.	Sulfhydryl Compounds	81-86	bolA family member 1	Homo sapiens	29-34
22746225-7	2013	Supporting a role of BOLA1 in controlling the mitochondrial thiol redox potential is that BOLA1 orthologs only occur in aerobic eukaryotes.	Sulfhydryl Compounds	60-65	bolA family member 1	Homo sapiens	21-26
22746225-10	2013	INNOVATION: We implicate a new protein, BOLA1, in the regulation of the mitochondrial thiol redox potential.	Sulfhydryl Compounds	86-91	bolA family member 1	Homo sapiens	40-45
22746225-11	2013	CONCLUSION: BOLA1 is an aerobic, mitochondrial protein that prevents mitochondrial morphology aberrations induced by GSH depletion and reduces the associated oxidative shift of the mitochondrial thiol redox potential.	Sulfhydryl Compounds	195-200	bolA family member 1	Homo sapiens	12-17
23180603-5	2013	Chemical modification of inhibitors, A3G mutational screening, and thiol reactivity studies implicate C321, a residue proximal to the active site, as the critical A3G target for this class of molecules.	Sulfhydryl Compounds	67-72	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	163-166
23841333-3	2013	Analysis of vibrational spectra and 13C and 1H NMR spectra revealed that thiol and glutamyl"s carboxylic groups are groups that cooperate in interaction with Cd2+ ions.	Sulfhydryl Compounds	73-78	CD2 molecule	Homo sapiens	158-161
23231413-5	2013	The chloromaleimide group of this compound is thought to act as a Michael acceptor and react with the thiol group on C319 of RAD51, using a conjugate addition-elimination mechanism.	Sulfhydryl Compounds	102-107	RAD51 recombinase	Homo sapiens	125-130
23547844-7	2013	H2S release mechanism from these donors was studied and proved to be thiol-dependent.	Sulfhydryl Compounds	69-74	histocompatibility 2, S region (C4, Slp, Bf, C2)	Mus musculus	0-3
23533997-8	2013	This alantolactone-induced apoptosis and GSH depletion were effectively inhibited or abrogated by a thiol antioxidant, N-acetyl-L-cysteine (NAC).	Sulfhydryl Compounds	100-105	X-linked Kx blood group	Homo sapiens	140-143
23161601-2	2013	Here, we report a novel protocol to analyze organic thiols by microchip CE with LIF detection.	Sulfhydryl Compounds	52-58	LIF interleukin 6 family cytokine	Homo sapiens	80-83
26317017-7	2013	In addition, Obtained results revealed that, in diabetics, G6PD activity negatively correlated to protein carbonyl and HbA1C (r = -0.77 and -0.65, resp.), while positively correlated to total thiol (r = 0.66) and protein carbonyl negatively correlated to total thiol (r = -0.85), while positively correlated to HbA1C (r = 0.43).	Sulfhydryl Compounds	192-197	glucose-6-phosphate dehydrogenase	Homo sapiens	59-63
24489546-6	2013	In this essay we discuss recent findings on how ERp44 governs such assembly control in a pH-dependent manner, shuttling between the cisGolgi and endoplasmic reticulum, and finally on how pERp1/MZB1, possibly as a co-chaperone of GRP94, may help to overrule the thiol-mediated retention in the activated B cell to give way to antibody secretion.	Sulfhydryl Compounds	261-266	endoplasmic reticulum protein 44	Homo sapiens	48-53
26317017-7	2013	In addition, Obtained results revealed that, in diabetics, G6PD activity negatively correlated to protein carbonyl and HbA1C (r = -0.77 and -0.65, resp.), while positively correlated to total thiol (r = 0.66) and protein carbonyl negatively correlated to total thiol (r = -0.85), while positively correlated to HbA1C (r = 0.43).	Sulfhydryl Compounds	261-266	glucose-6-phosphate dehydrogenase	Homo sapiens	59-63
26317017-8	2013	Also in controls, G6PD activity negatively correlated to protein carbonyl and HbA1C (r = -0.57 and -0.56, resp.), while positively correlated to total thiol (r = 0.5) and protein carbonyl negatively correlated to total thiol (r = -0.48), while positively correlated to HbA1C (r = 0.68).	Sulfhydryl Compounds	151-156	glucose-6-phosphate dehydrogenase	Homo sapiens	18-22
26317017-8	2013	Also in controls, G6PD activity negatively correlated to protein carbonyl and HbA1C (r = -0.57 and -0.56, resp.), while positively correlated to total thiol (r = 0.5) and protein carbonyl negatively correlated to total thiol (r = -0.48), while positively correlated to HbA1C (r = 0.68).	Sulfhydryl Compounds	219-224	glucose-6-phosphate dehydrogenase	Homo sapiens	18-22
23381866-5	2013	We describe here the technical protocols of using thiol-sensitive fluorogenic probes for the fluorescent analysis of enzymatic activities of KATs, with males on the first (MOF) as an exemplary KAT enzyme.	Sulfhydryl Compounds	50-55	thiosulfate sulfurtransferase like domain containing 1	Homo sapiens	141-144
23719925-5	2013	The sensitivity and reliability of the assay was confirmed by atomic absorption spectrometry with recombinant Keap1 as a model thiol protein.	Sulfhydryl Compounds	127-132	kelch like ECH associated protein 1	Homo sapiens	110-115
23255003-6	2013	The C-terminal Cys of the extra light chain in Peak 1 variants is either a free thiol, capped by glutathione, cysteine, or another light chain.	Sulfhydryl Compounds	80-85	inactive tyrosine-protein kinase PEAK1	Cricetulus griseus	47-53
23709032-1	2013	cGMP-dependent protein kinase, also known as protein kinase G (PKG), is activated independently of cGMP by a novel thiol-reactive mechanism involving the formation of an intermolecular disulfide.	Sulfhydryl Compounds	115-120	protein kinase cGMP-dependent 1	Homo sapiens	45-61
23709032-1	2013	cGMP-dependent protein kinase, also known as protein kinase G (PKG), is activated independently of cGMP by a novel thiol-reactive mechanism involving the formation of an intermolecular disulfide.	Sulfhydryl Compounds	115-120	protein kinase cGMP-dependent 1	Homo sapiens	63-66
23849862-4	2013	However, PKA and PKG can also be functionally modulated independently of cyclic nucleotide stimulation through direct cysteine thiol oxidation leading to intermolecular disulfide formation.	Sulfhydryl Compounds	127-132	protein kinase cGMP-dependent 1	Homo sapiens	17-20
22824136-8	2013	Pre-treatment with the highly specific NR2B subunit inhibitor, ifenprodil, partially decreased PILO-mediated thiol oxidation and was not effective in preventing apoptosis and cell death.	Sulfhydryl Compounds	109-114	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	39-43
23581414-3	2013	Total thiol (Ttl) is considered a plasma antioxidant and high density lipoprotein (HDL)- dependent paraoxonase l (PON1) is known as a free radical scavenger.	Sulfhydryl Compounds	6-11	paraoxonase 1	Homo sapiens	114-118
23970950-5	2013	On the other hand, Tkl1p activity was sensitive to thiol redox modification and although Cys622 could be glutathionylated to a limited extent, it was not a natural substrate of Grx2p.	Sulfhydryl Compounds	51-56	transketolase TKL1	Saccharomyces cerevisiae S288C	19-24
26855455-2	2013	This perspective surveys established and proposed molecular mechanisms of Nrf2 activation by phytochemicals with a special emphasis on a common chemical property of Nrf2 activators: the ability as "soft" electrophiles to modify cellular thiols, either directly or as oxidized biotransformants.	Sulfhydryl Compounds	237-243	NFE2 like bZIP transcription factor 2	Homo sapiens	165-169
23536773-0	2013	Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages.	Sulfhydryl Compounds	37-42	signal transducer and activator of transcription 1	Mus musculus	70-76
23536773-0	2013	Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages.	Sulfhydryl Compounds	37-42	interferon regulatory factor 1	Mus musculus	77-82
23536773-0	2013	Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages.	Sulfhydryl Compounds	37-42	interleukin 12b	Mus musculus	107-116
23536773-0	2013	Molecules altering the intracellular thiol content modulate NF-kB and STAT-1/IRF-1 signalling pathways and IL-12 p40 and IL-27 p28 production in murine macrophages.	Sulfhydryl Compounds	37-42	interleukin 27	Mus musculus	121-130
23349873-6	2013	Using thiol-specific biotin labeling strategies, we determined that ATP-dependent EGFR transactivation was associated with DUOX1-dependent oxidation of cysteine residues within Src as well as ADAM17.	Sulfhydryl Compounds	6-11	epidermal growth factor receptor	Homo sapiens	82-86
23349873-6	2013	Using thiol-specific biotin labeling strategies, we determined that ATP-dependent EGFR transactivation was associated with DUOX1-dependent oxidation of cysteine residues within Src as well as ADAM17.	Sulfhydryl Compounds	6-11	dual oxidase 1	Homo sapiens	123-128
23349873-6	2013	Using thiol-specific biotin labeling strategies, we determined that ATP-dependent EGFR transactivation was associated with DUOX1-dependent oxidation of cysteine residues within Src as well as ADAM17.	Sulfhydryl Compounds	6-11	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	177-180
23349873-6	2013	Using thiol-specific biotin labeling strategies, we determined that ATP-dependent EGFR transactivation was associated with DUOX1-dependent oxidation of cysteine residues within Src as well as ADAM17.	Sulfhydryl Compounds	6-11	ADAM metallopeptidase domain 17	Homo sapiens	192-198
23073660-4	2012	Reduced all-thiol-HMGB1 has sole chemokine activity, whereas disulfide-HMGB1 has only cytokine activity, and oxidized, denatured HMGB1 has neither.	Sulfhydryl Compounds	12-17	high mobility group box 1	Homo sapiens	18-23
22975676-0	2012	Identification of proteins containing redox-sensitive thiols after PRDX1, PRDX3 and GCLC silencing and/or glucose oxidase treatment in Hepa 1-6 cells.	Sulfhydryl Compounds	54-60	peroxiredoxin 1	Mus musculus	67-72
22975676-0	2012	Identification of proteins containing redox-sensitive thiols after PRDX1, PRDX3 and GCLC silencing and/or glucose oxidase treatment in Hepa 1-6 cells.	Sulfhydryl Compounds	54-60	peroxiredoxin 3	Mus musculus	74-79
22975676-0	2012	Identification of proteins containing redox-sensitive thiols after PRDX1, PRDX3 and GCLC silencing and/or glucose oxidase treatment in Hepa 1-6 cells.	Sulfhydryl Compounds	54-60	glutamate-cysteine ligase, catalytic subunit	Mus musculus	84-88
23176598-4	2012	Disulfide-linked dimers produced by Cu(2+) oxidation of the free-thiol form of the protein demonstrated picomolar affinity for VEGF in solution, comparable to that of a D2-Fc fusion (sFLT01) and ~50-fold higher than monomeric D2, suggesting the 26 a.a. tag length between the two D2 domains permits simultaneous interaction of both faces of the VEGF homodimer.	Sulfhydryl Compounds	65-70	vascular endothelial growth factor A	Homo sapiens	127-131
23123111-7	2012	The conserved C-terminal cysteine of HypE can access the thiol redox cascade of HypD.	Sulfhydryl Compounds	57-62	FIC domain protein adenylyltransferase	Homo sapiens	37-41
23176598-4	2012	Disulfide-linked dimers produced by Cu(2+) oxidation of the free-thiol form of the protein demonstrated picomolar affinity for VEGF in solution, comparable to that of a D2-Fc fusion (sFLT01) and ~50-fold higher than monomeric D2, suggesting the 26 a.a. tag length between the two D2 domains permits simultaneous interaction of both faces of the VEGF homodimer.	Sulfhydryl Compounds	65-70	vascular endothelial growth factor A	Homo sapiens	345-349
23205738-11	2012	C(384)X mutants were BLT-1-resistant, supporting the proposal that Cys(384)"s thiol interacts with BLT-1.	Sulfhydryl Compounds	78-83	leukotriene B4 receptor	Homo sapiens	21-26
23205738-11	2012	C(384)X mutants were BLT-1-resistant, supporting the proposal that Cys(384)"s thiol interacts with BLT-1.	Sulfhydryl Compounds	78-83	leukotriene B4 receptor	Homo sapiens	99-104
23085580-8	2012	Interestingly, low non cytotoxic concentrations of Cd increased the gene expression of macrophage migration inhibitory factor (MIF), also a thiol-containing protein.	Sulfhydryl Compounds	140-145	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	87-125
23085580-8	2012	Interestingly, low non cytotoxic concentrations of Cd increased the gene expression of macrophage migration inhibitory factor (MIF), also a thiol-containing protein.	Sulfhydryl Compounds	140-145	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	127-130
23085580-11	2012	By gel-filtration chromatography, we demonstrated that MIF acts as a thiol-containing protein and thereby promotes Cd complexation.	Sulfhydryl Compounds	69-74	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	55-58
23217300-4	2012	The thiols adducts were separated by an isocratic elution on a Platinum EPS C18 analytical column (53mmx7mm I.D., 3mum) using a phosphate buffer containing 4% of acetonitrile as a mobile phase.	Sulfhydryl Compounds	4-10	Bardet-Biedl syndrome 9	Homo sapiens	76-79
23123111-7	2012	The conserved C-terminal cysteine of HypE can access the thiol redox cascade of HypD.	Sulfhydryl Compounds	57-62	MAGE family member A3	Homo sapiens	80-84
22814119-5	2012	First, a monolayer of cyt c is prepared on a thiol-modified gold electrode and investigated with PQQ-GDH in solution.	Sulfhydryl Compounds	45-50	cytochrome c, somatic	Homo sapiens	22-27
23354816-12	2012	A thiol-activated cytolysin was predicted in the region of 105 to 1579, which acts as a functional domain of the toxin.	Sulfhydryl Compounds	2-7	perforin 1	Homo sapiens	18-27
22949627-1	2012	E2072 [(3-2-mercaptoethyl)biphenyl-2,3"-dicarboxylic acid] is a novel, potent and selective thiol-based glutamate carboxypeptidase II (GCP-II) inhibitor that has shown robust analgesic and neuroprotective efficacy in preclinical models of neuropathic pain and chemotherapy-induced peripheral neuropathy.	Sulfhydryl Compounds	92-97	folate hydrolase 1	Rattus norvegicus	104-133
22949627-1	2012	E2072 [(3-2-mercaptoethyl)biphenyl-2,3"-dicarboxylic acid] is a novel, potent and selective thiol-based glutamate carboxypeptidase II (GCP-II) inhibitor that has shown robust analgesic and neuroprotective efficacy in preclinical models of neuropathic pain and chemotherapy-induced peripheral neuropathy.	Sulfhydryl Compounds	92-97	folate hydrolase 1	Rattus norvegicus	135-141
23667907-0	2012	Molecular determinants of human dipeptidyl peptidase III sensitivity to thiol modifying reagents.	Sulfhydryl Compounds	72-77	dipeptidyl peptidase 3	Homo sapiens	32-56
22989881-12	2012	To establish the unique influence of the S-nitroso group, our study describes high resolution three-dimensional structures of human apo-S100A1 protein with the Cys(85) thiol group in reduced and S-nitrosylated states.	Sulfhydryl Compounds	168-173	S100 calcium binding protein A1	Homo sapiens	136-142
22918627-1	2012	The aims of this study were to optimize the experimental conditions for labeling extracellularly oriented, solvent-exposed cysteine residues of gamma-aminobutyric acid transporter 1 (GAT1) with the membrane-impermeant sulfhydryl reagent [2-(trimethylammonium)ethyl]methanethiosulfonate (MTSET) and to characterize the functional and pharmacological consequences of labeling on transporter steady-state and presteady-state kinetic properties.	Sulfhydryl Compounds	218-228	solute carrier family 6 member 1	Homo sapiens	144-181
22918627-1	2012	The aims of this study were to optimize the experimental conditions for labeling extracellularly oriented, solvent-exposed cysteine residues of gamma-aminobutyric acid transporter 1 (GAT1) with the membrane-impermeant sulfhydryl reagent [2-(trimethylammonium)ethyl]methanethiosulfonate (MTSET) and to characterize the functional and pharmacological consequences of labeling on transporter steady-state and presteady-state kinetic properties.	Sulfhydryl Compounds	218-228	solute carrier family 6 member 1	Homo sapiens	183-187
22985967-4	2012	Tsa1 (thiol-specific antioxidant protein 1 from yeast) is by far the most abundant Cys-based peroxidase in Saccharomyces cerevisiae.	Sulfhydryl Compounds	6-11	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	0-4
22486562-7	2012	Menadione and paraquat, 2 pro-oxidants metabolized via NQO1, induced KLF6(Full)  mRNA in a thiol-dependent manner.	Sulfhydryl Compounds	91-96	NAD(P)H quinone dehydrogenase 1	Homo sapiens	55-59
22989881-3	2012	CONCLUSION: Thiol-aromatic molecular switch is responsible for NO-related modification of S100A1 properties.	Sulfhydryl Compounds	12-17	S100 calcium binding protein A1	Homo sapiens	90-96
23009681-0	2012	Myeloperoxidase catalyzes the conjugation of serotonin to thiols via free radicals and tryptamine-4,5-dione.	Sulfhydryl Compounds	58-64	myeloperoxidase	Homo sapiens	0-15
23009681-7	2012	Both caused a loss of thiols on GAPDH and covalent attachment of quinones derived from TD to the protein.	Sulfhydryl Compounds	22-28	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	32-37
23009681-11	2012	Our results indicate that myeloperoxidase can oxidize serotonin to species that form adducts with low molecular weight thiols and cysteine residues in proteins.	Sulfhydryl Compounds	119-125	myeloperoxidase	Homo sapiens	26-41
22486562-7	2012	Menadione and paraquat, 2 pro-oxidants metabolized via NQO1, induced KLF6(Full)  mRNA in a thiol-dependent manner.	Sulfhydryl Compounds	91-96	Kruppel like factor 6	Homo sapiens	69-73
22374717-9	2012	However, heterologous expression of PON1 in cell-based systems revealed that PON1 cannot generate H4, but mediates the formation of another thiol metabolite, termed Endo.	Sulfhydryl Compounds	140-145	paraoxonase 1	Homo sapiens	77-81
22374717-9	2012	However, heterologous expression of PON1 in cell-based systems revealed that PON1 cannot generate H4, but mediates the formation of another thiol metabolite, termed Endo.	Sulfhydryl Compounds	140-145	mannosidase endo-alpha	Homo sapiens	165-169
22492841-3	2012	Our aim was to determine whether the  levels of PRDX1 and PRDX6 and their oxidation on thiol groups are associated  with a decrease in sperm motility and DNA integrity.	Sulfhydryl Compounds	87-92	peroxiredoxin 1	Homo sapiens	48-53
22801553-6	2012	We show here that the non-conserved cysteines are free thiols as a Gpc-1 core protein containing the C-terminal stalk could be biotinylated by 1-biotinamido-4-(4"-[maleimidomethyl-cyclohexane]-carboxyamido)butane.	Sulfhydryl Compounds	55-61	glypican 1	Homo sapiens	67-72
22492841-3	2012	Our aim was to determine whether the  levels of PRDX1 and PRDX6 and their oxidation on thiol groups are associated  with a decrease in sperm motility and DNA integrity.	Sulfhydryl Compounds	87-92	peroxiredoxin 6	Homo sapiens	58-63
22659318-8	2012	Our results indicate that Cd also induces HO-1 expression which is modulated by the thiol redox status, tyrosine kinase and PI3-kinase.	Sulfhydryl Compounds	84-89	heme oxygenase 1	Homo sapiens	42-46
22837314-2	2012	A previous study from our laboratory established Cys222 in transmembrane (TM) 6 as the residue responsible for methyl methanethiosulfonate (a membrane-permeable sulfhydryl modifier)-mediated enhancement of the binding of the ENT1 inhibitor nitrobenzylmercaptopurine riboside (NBMPR) in intact cells.	Sulfhydryl Compounds	161-171	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	225-229
22904075-4	2012	Our results support a model in which HLTF forms a thiol-linked Ub chain on UBC13 (UBC13~Ubn) and then transfers the chain to RAD6~Ub, forming RAD6~Ubn+1.	Sulfhydryl Compounds	50-55	helicase like transcription factor	Homo sapiens	37-41
22904075-4	2012	Our results support a model in which HLTF forms a thiol-linked Ub chain on UBC13 (UBC13~Ubn) and then transfers the chain to RAD6~Ub, forming RAD6~Ubn+1.	Sulfhydryl Compounds	50-55	ubiquitin conjugating enzyme E2 N	Homo sapiens	75-80
22904075-4	2012	Our results support a model in which HLTF forms a thiol-linked Ub chain on UBC13 (UBC13~Ubn) and then transfers the chain to RAD6~Ub, forming RAD6~Ubn+1.	Sulfhydryl Compounds	50-55	ubiquitin conjugating enzyme E2 N	Homo sapiens	82-91
22971010-9	2012	Thiol reduction with dithiothreitol decreased HIF-1alpha stabilization in hypoxic cells, while dinitrochlorobenzene, which stabilizes S-nitrosothiols, favored its accumulation.	Sulfhydryl Compounds	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56
23067373-4	2012	The self-association of vWF is also supported by a rapidly expanding reservoir of novel evidences that the thiol/disulfide exchange regulates vWF multimer size in the blood circulation.	Sulfhydryl Compounds	107-112	von Willebrand factor	Homo sapiens	24-27
22854047-4	2012	Stimulation of human microvascular endothelial (HME) cells with VEGF (20 ng/ml) or peroxynitrite (1 microM) caused an immediate and reversible negative-shift in the cellular redox-state and thiol oxidation of LMW-PTP, which culminated in cell migration.	Sulfhydryl Compounds	190-195	vascular endothelial growth factor A	Homo sapiens	64-68
23067373-4	2012	The self-association of vWF is also supported by a rapidly expanding reservoir of novel evidences that the thiol/disulfide exchange regulates vWF multimer size in the blood circulation.	Sulfhydryl Compounds	107-112	von Willebrand factor	Homo sapiens	142-145
22864587-15	2012	These results suggest that Pb inhibits delta-ALAD and PK activity by interacting with their thiol groups.	Sulfhydryl Compounds	92-97	aminolevulinate dehydratase	Homo sapiens	39-49
22714274-2	2012	Insulin fibrils were disaggregated into insulin A- and B-chains in 14 M (w/v) NH(4)OH for 2 h at 60  C. Insulin monomers, with a MW of ~5,882 Da, were then regenerated by oxidation of sulfhydryls with 30 % (w/v) H(2)O(2) (10 M) for 12 h at 25  C. No two A-chains or two B-chains of insulin formed during the oxidation process.	Sulfhydryl Compounds	184-195	insulin	Homo sapiens	0-7
22714274-2	2012	Insulin fibrils were disaggregated into insulin A- and B-chains in 14 M (w/v) NH(4)OH for 2 h at 60  C. Insulin monomers, with a MW of ~5,882 Da, were then regenerated by oxidation of sulfhydryls with 30 % (w/v) H(2)O(2) (10 M) for 12 h at 25  C. No two A-chains or two B-chains of insulin formed during the oxidation process.	Sulfhydryl Compounds	184-195	insulin	Homo sapiens	104-111
22656049-3	2012	We found that SIN-1 is &gt; 30 times potent in causing thiol oxidation than AAPH.	Sulfhydryl Compounds	55-60	MAPK associated protein 1	Homo sapiens	14-19
23019539-4	2012	In this work, we introduce a reactive thiol onto TGFbeta and covalently tether the growth factor into poly(ethylene glycol) (PEG) hydrogels using a photoinitiated thiol-acrylate polymerization mechanism.	Sulfhydryl Compounds	38-43	transforming growth factor beta 1	Homo sapiens	49-56
23019539-4	2012	In this work, we introduce a reactive thiol onto TGFbeta and covalently tether the growth factor into poly(ethylene glycol) (PEG) hydrogels using a photoinitiated thiol-acrylate polymerization mechanism.	Sulfhydryl Compounds	163-168	transforming growth factor beta 1	Homo sapiens	49-56
22966037-5	2012	Electrophiles and oxidants modify critical cysteine thiols of Keap1 and Nrf2 to inhibit Nrf2 ubiquitination, leading to Nrf2 activation and induction.	Sulfhydryl Compounds	52-58	kelch-like ECH-associated protein 1	Mus musculus	62-67
22966037-5	2012	Electrophiles and oxidants modify critical cysteine thiols of Keap1 and Nrf2 to inhibit Nrf2 ubiquitination, leading to Nrf2 activation and induction.	Sulfhydryl Compounds	52-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
22966037-5	2012	Electrophiles and oxidants modify critical cysteine thiols of Keap1 and Nrf2 to inhibit Nrf2 ubiquitination, leading to Nrf2 activation and induction.	Sulfhydryl Compounds	52-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
22920299-6	2012	Unexpectedly, glutathione (GSH) exerted a negative effect on the affinity of GSTP1-1 for JNK1alpha2, suggesting that the intracellular levels of this thiol may allow a fine-tuning of the MAPK signaling pathway.	Sulfhydryl Compounds	150-155	glutathione S-transferase pi 1	Homo sapiens	77-84
22728235-3	2012	IR data revealed that the ligand behaves as monobasic tridentate through (CN)(py), (C-S) and new azomethine, (NC)(*) groups in the Co(II) complex but in Cu(II) complex, the ligand coordinate via both (CS) groups, one of them in thiol form as well as the new azomethine group.	Sulfhydryl Compounds	228-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-137
22913736-3	2012	Time-resolved dynamic light scattering (DLS), disk centrifuge photosedimentometry (DCP), and circular dichroism (CD) spectroscopy studies confirm that bovine serum albumin (BSA) adsorbs rapidly onto the cationic poly(vinyl amine)-stabilized polypyrrole nanoparticles and suggest that the initial well-defined protein coronal is subsequently cross-linked via thiol-disulfide exchange.	Sulfhydryl Compounds	358-363	albumin	Homo sapiens	158-171
22917445-0	2012	Synthesis of 2,5-bis(spirocyclohexane)-substituted nitroxides of pyrroline and pyrrolidine series, including thiol-specific spin label: an analogue of MTSSL with long relaxation time.	Sulfhydryl Compounds	109-114	spindlin 1	Homo sapiens	124-128
22957582-10	2012	We predict the frequency of a vibrational mode of the thiol H atom to increase by a factor ~2 as the gap between the tip and molecule narrows.	Sulfhydryl Compounds	54-59	transcription termination factor 2	Homo sapiens	84-93
22686525-4	2012	The key to CS-dependent Nrf2 activation is assumed to be based on the long-known phenomenon of a general strong sulfhydryl (-SH) reactivity inherent to CS.	Sulfhydryl Compounds	112-122	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
22967596-1	2012	A nanocomposite obtained by a thiol DAB-dendrimer (generation 5), coated with fluorescent ZnSe quantum dots, was successfully synthesized for the selective recognition of C-reactive protein.	Sulfhydryl Compounds	30-35	C-reactive protein	Homo sapiens	171-189
22791808-1	2012	Thioredoxin reductase 1 (TR1) controls the redox state of protein thiols in mammalian cells and has been shown to have roles in both preventing and promoting cancer.	Sulfhydryl Compounds	66-72	thioredoxin reductase 1	Homo sapiens	0-23
27847448-3	2012	Here we have used dithiothreitol (DTT) as model of vicinal thiol-containing enzymes, namely delta-aminolevulinate dehydratase.	Sulfhydryl Compounds	59-64	aminolevulinate dehydratase	Homo sapiens	92-125
22730391-5	2012	We showed that sGC activity is impaired by thiol S-nitrosation.	Sulfhydryl Compounds	43-48	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	15-18
22684031-11	2012	The effect of HK-156 on LPS-induced activation of NF-kappaB signaling was dependent on thiol groups of cysteines in upstream proteins.	Sulfhydryl Compounds	87-92	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-59
22627382-7	2012	Oxidation and glycation levels were found to be enhanced in albumin purified from diabetic patients or glycated with glucose or methylglyoxal, after determination of their ketoamine, free thiol, amino group and carbonyl contents.	Sulfhydryl Compounds	188-193	albumin	Homo sapiens	60-67
22791808-1	2012	Thioredoxin reductase 1 (TR1) controls the redox state of protein thiols in mammalian cells and has been shown to have roles in both preventing and promoting cancer.	Sulfhydryl Compounds	66-72	thioredoxin reductase 1	Homo sapiens	25-28
22704541-2	2012	We present evidence that disulfide bonds in FXI are reduced to free thiols by oxidoreductases thioredoxin-1 (TRX-1) and protein disulfide isomerase (PDI).	Sulfhydryl Compounds	68-74	coagulation factor XI	Homo sapiens	44-47
22704541-2	2012	We present evidence that disulfide bonds in FXI are reduced to free thiols by oxidoreductases thioredoxin-1 (TRX-1) and protein disulfide isomerase (PDI).	Sulfhydryl Compounds	68-74	thioredoxin	Homo sapiens	94-107
22704541-2	2012	We present evidence that disulfide bonds in FXI are reduced to free thiols by oxidoreductases thioredoxin-1 (TRX-1) and protein disulfide isomerase (PDI).	Sulfhydryl Compounds	68-74	thioredoxin	Homo sapiens	109-114
22704541-2	2012	We present evidence that disulfide bonds in FXI are reduced to free thiols by oxidoreductases thioredoxin-1 (TRX-1) and protein disulfide isomerase (PDI).	Sulfhydryl Compounds	68-74	prolyl 4-hydroxylase subunit beta	Homo sapiens	120-147
22704541-2	2012	We present evidence that disulfide bonds in FXI are reduced to free thiols by oxidoreductases thioredoxin-1 (TRX-1) and protein disulfide isomerase (PDI).	Sulfhydryl Compounds	68-74	prolyl 4-hydroxylase subunit beta	Homo sapiens	149-152
22407514-5	2012	Our findings showed that there is a significant increase in lipid peroxidation in AlP ingested group along with a reduction in total antioxidant capacity and total thiols groups.	Sulfhydryl Compounds	164-170	ATHS	Homo sapiens	82-85
22476940-9	2012	These data implicate thiol-disulfide exchange reactions in the initial tethering of apoptotic cells to macrophage and establish P2X7 as one of the scavenger receptors involved in the recognition and removal of apoptotic cells in the absence of extracellular ATP and serum.	Sulfhydryl Compounds	21-26	purinergic receptor P2X 7	Homo sapiens	128-132
22809627-0	2012	The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds.	Sulfhydryl Compounds	78-83	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	16-20
22809627-2	2012	We demonstrate that diverse thiol-reactive molecules potently activate budding yeast Hsf1.	Sulfhydryl Compounds	28-33	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	85-89
22809627-3	2012	Hsf1 activation by thiol-reactive compounds is not consistent with the stresses of misfolding of cytoplasmic proteins or cytotoxicity.	Sulfhydryl Compounds	19-24	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	0-4
22809627-4	2012	Instead, we demonstrate that the Hsp70 chaperone Ssa1, which represses Hsf1 in the absence of stress, is hypersensitive to modification by a thiol-reactive probe.	Sulfhydryl Compounds	141-146	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	49-53
22809627-4	2012	Instead, we demonstrate that the Hsp70 chaperone Ssa1, which represses Hsf1 in the absence of stress, is hypersensitive to modification by a thiol-reactive probe.	Sulfhydryl Compounds	141-146	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	71-75
22809627-5	2012	Strikingly, mutation of two conserved cysteine residues to serine in Ssa1 rendered cells insensitive to Hsf1 activation and subsequently induced thermotolerance by thiol-reactive compounds, but not by heat shock.	Sulfhydryl Compounds	164-169	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	69-73
22809627-7	2012	Cysteine 303, located within the nucleotide-binding domain, was found to be modified in vivo by a model organic electrophile, demonstrating that Ssa1 is a direct target for thiol-reactive molecules through adduct formation.	Sulfhydryl Compounds	173-178	Hsp70 family ATPase SSA1	Saccharomyces cerevisiae S288C	145-149
22817838-5	2012	In the present study, we assessed whether redox regulation of thiol residues contained in IRF-3, which are priviledged redox sensors, play a role in its regulation following Sendai virus infection, using a combination of mutation of Cysteine (Cys) residues into Alanine and thiols alkylation using N-ethyl maleimide.	Sulfhydryl Compounds	62-67	interferon regulatory factor 3	Homo sapiens	90-95
22817838-5	2012	In the present study, we assessed whether redox regulation of thiol residues contained in IRF-3, which are priviledged redox sensors, play a role in its regulation following Sendai virus infection, using a combination of mutation of Cysteine (Cys) residues into Alanine and thiols alkylation using N-ethyl maleimide.	Sulfhydryl Compounds	274-280	interferon regulatory factor 3	Homo sapiens	90-95
22921065-3	2012	Here, we demonstrate that certain amino acid substitutions (in particular those containing hydroxyl or thiol groups) in the conserved GGQ glutamine of release factor RF1 can rescue defects in the release reaction associated with peptidyl-tRNA substrates lacking a 2" OH.	Sulfhydryl Compounds	103-108	mitochondrial translation release factor 1	Homo sapiens	166-169
22683714-9	2012	C-2 (with the highest activity) was also tested in vivo and was administered at three different doses, i.e. 15, 30 and 50 mg/kg to get an exact idea about its interaction with thiol containing molecules (NPSH) and enzyme alpha-ALA-D (sulfhydryl containing enzyme).	Sulfhydryl Compounds	176-181	complement C2	Rattus norvegicus	0-3
22683714-9	2012	C-2 (with the highest activity) was also tested in vivo and was administered at three different doses, i.e. 15, 30 and 50 mg/kg to get an exact idea about its interaction with thiol containing molecules (NPSH) and enzyme alpha-ALA-D (sulfhydryl containing enzyme).	Sulfhydryl Compounds	234-244	complement C2	Rattus norvegicus	0-3
22819842-6	2012	Using a proteomics approach with the thiol-specific probe, 5-iodoacetamidofluorescein, we show that several proteins including peptidylprolyl isomerase A (cyclophilin A), protein disulfide isomerase, glyceraldehyde-3-phosphate dehydrogenase and galectin-1 are particularly sensitive to oxidation by HOCl and N-chloramines formed at inflammatory sites.	Sulfhydryl Compounds	37-42	prolyl 4-hydroxylase subunit beta	Homo sapiens	127-198
22819842-6	2012	Using a proteomics approach with the thiol-specific probe, 5-iodoacetamidofluorescein, we show that several proteins including peptidylprolyl isomerase A (cyclophilin A), protein disulfide isomerase, glyceraldehyde-3-phosphate dehydrogenase and galectin-1 are particularly sensitive to oxidation by HOCl and N-chloramines formed at inflammatory sites.	Sulfhydryl Compounds	37-42	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	200-240
22819842-6	2012	Using a proteomics approach with the thiol-specific probe, 5-iodoacetamidofluorescein, we show that several proteins including peptidylprolyl isomerase A (cyclophilin A), protein disulfide isomerase, glyceraldehyde-3-phosphate dehydrogenase and galectin-1 are particularly sensitive to oxidation by HOCl and N-chloramines formed at inflammatory sites.	Sulfhydryl Compounds	37-42	galectin 1	Homo sapiens	245-255
22677779-1	2012	A myoglobin-cadmium telluride quantum dot conjugate was constructed using an artificial heme modified with a thiol moiety as a linker.	Sulfhydryl Compounds	109-114	myoglobin	Homo sapiens	2-11
22732185-2	2012	Given the high susceptibility of sulfhydryl groups to oxidation, we here suggest the use of a protein thiolation index (PTI), i.e., the molar ratio between the sum of all low molecular mass thiols bound to plasma proteins (forming, as a whole, S-thiolated proteins) and protein free cysteinyl residues, as a suitable biomarker of oxidative stress.	Sulfhydryl Compounds	190-196	serpin family B member 6	Homo sapiens	120-123
22834560-4	2012	Cyanotoxins containing Mdha or Dha reacted readily with thiols, whereas Mser, Ser, Mdhb, and thiol-derivatives of Mdha or Dha did not react under the conditions used.	Sulfhydryl Compounds	56-62	malate dehydrogenase 1	Homo sapiens	23-27
22834560-4	2012	Cyanotoxins containing Mdha or Dha reacted readily with thiols, whereas Mser, Ser, Mdhb, and thiol-derivatives of Mdha or Dha did not react under the conditions used.	Sulfhydryl Compounds	56-61	malate dehydrogenase 1	Homo sapiens	23-27
22787113-8	2012	Substitution of ET(B)-Cys405 with alanine improved ET(B)-dependent NO( ) synthesis under conditions of oxidant stress, confirming that Cys405 is a redox-sensitive thiol that is necessary for ET(B)-eNOS signaling.	Sulfhydryl Compounds	163-168	endothelin receptor type B	Homo sapiens	16-21
22787113-8	2012	Substitution of ET(B)-Cys405 with alanine improved ET(B)-dependent NO( ) synthesis under conditions of oxidant stress, confirming that Cys405 is a redox-sensitive thiol that is necessary for ET(B)-eNOS signaling.	Sulfhydryl Compounds	163-168	endothelin receptor type B	Homo sapiens	51-56
22794164-6	2012	The binding of free-thiol Fab and intact Fab to its antigen was measured in a cell-based binding assay and an enzyme linked immunosorbent assay.	Sulfhydryl Compounds	20-25	FA complementation group B	Homo sapiens	26-29
22794164-8	2012	Consistent with these Fab binding data, the enriched intact mAb A containing free thiols was determined to be fully active in a potency assay.	Sulfhydryl Compounds	82-88	FA complementation group B	Homo sapiens	22-25
22609960-7	2012	Treatment with a thiol antioxidant, NAC, showed the recovery of GSH depletion and the reduction of reactive oxygen species levels in MMPT-treated cells, which were accompanied by the inhibition of apoptosis.	Sulfhydryl Compounds	17-22	X-linked Kx blood group	Homo sapiens	36-39
22741550-7	2012	When the cytokine TGFbeta was encapsulated in PEG hydrogels formed via the thiol-ene reaction, full protein bioactivity was preserved.	Sulfhydryl Compounds	75-80	transforming growth factor beta 1	Homo sapiens	18-25
22481091-4	2012	These reactions generate the production of reactive oxygen species (ROS) as a byproduct of thiol/disulfide exchange reaction among ER oxidoreductin 1 (Ero1), protein disulfide isomerase (PDI) and ER client proteins, during the formation of disulfide bonds in nascent or incorrectly folded proteins.	Sulfhydryl Compounds	91-96	prolyl 4-hydroxylase subunit beta	Homo sapiens	158-185
22481091-4	2012	These reactions generate the production of reactive oxygen species (ROS) as a byproduct of thiol/disulfide exchange reaction among ER oxidoreductin 1 (Ero1), protein disulfide isomerase (PDI) and ER client proteins, during the formation of disulfide bonds in nascent or incorrectly folded proteins.	Sulfhydryl Compounds	91-96	prolyl 4-hydroxylase subunit beta	Homo sapiens	187-190
22732400-7	2012	Interestingly, only the thiol antioxidants significantly abolished GB-enhanced AMPK activation.	Sulfhydryl Compounds	24-29	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	79-83
22825713-6	2012	Use of variety of thiol reagents indicates that the connexin hemichannel pore is large and flexible enough, at least in the extracellular part of the pore funnel, to accommodate uncommonly large side chains.	Sulfhydryl Compounds	18-23	LOC100128922	Homo sapiens	52-60
22855054-1	2012	In non-excitable cells, thiol-oxidizing agents have been shown to evoke oscillations in cytosolic free Ca(2+) concentration ([Ca(2+)](i)) by increasing the sensitivity of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) to IP(3).	Sulfhydryl Compounds	24-29	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	205-220
22855054-1	2012	In non-excitable cells, thiol-oxidizing agents have been shown to evoke oscillations in cytosolic free Ca(2+) concentration ([Ca(2+)](i)) by increasing the sensitivity of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) to IP(3).	Sulfhydryl Compounds	24-29	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	222-228
22855054-2	2012	Although thiol modification of the IP(3)R is implicated in this response, the molecular nature of the modification(s) responsible for changes in channel activity is still not well understood.	Sulfhydryl Compounds	9-14	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	35-41
22855054-10	2012	Collectively our results reveal that thiol-oxidizing agents primarily increase the sensitivity of the IP(3)R to Ca(2+), i.e. enhanced CICR, and suggest that glutathionylation may represent a fundamental mechanism for regulating IP(3)R activity during physiological redox signalling and during pathologicalical oxidative stress.	Sulfhydryl Compounds	37-42	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	102-108
22855054-10	2012	Collectively our results reveal that thiol-oxidizing agents primarily increase the sensitivity of the IP(3)R to Ca(2+), i.e. enhanced CICR, and suggest that glutathionylation may represent a fundamental mechanism for regulating IP(3)R activity during physiological redox signalling and during pathologicalical oxidative stress.	Sulfhydryl Compounds	37-42	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	228-234
22584220-6	2012	It was observed that the AM was slowly converted to the thiol conjugate, with a half-life of ~10 h. Addition of dithiothreitol to the reaction mixture reversed the conversion, which resulted in a decrease in AM-thiol conjugate levels and a concomitant increase in AM levels, whereas addition of NAC led to the formation of AM-NAC and a concomitant decrease in AM-GSH levels.	Sulfhydryl Compounds	56-61	X-linked Kx blood group	Homo sapiens	295-298
22584220-6	2012	It was observed that the AM was slowly converted to the thiol conjugate, with a half-life of ~10 h. Addition of dithiothreitol to the reaction mixture reversed the conversion, which resulted in a decrease in AM-thiol conjugate levels and a concomitant increase in AM levels, whereas addition of NAC led to the formation of AM-NAC and a concomitant decrease in AM-GSH levels.	Sulfhydryl Compounds	56-61	X-linked Kx blood group	Homo sapiens	326-329
22584220-6	2012	It was observed that the AM was slowly converted to the thiol conjugate, with a half-life of ~10 h. Addition of dithiothreitol to the reaction mixture reversed the conversion, which resulted in a decrease in AM-thiol conjugate levels and a concomitant increase in AM levels, whereas addition of NAC led to the formation of AM-NAC and a concomitant decrease in AM-GSH levels.	Sulfhydryl Compounds	211-216	X-linked Kx blood group	Homo sapiens	295-298
22584220-6	2012	It was observed that the AM was slowly converted to the thiol conjugate, with a half-life of ~10 h. Addition of dithiothreitol to the reaction mixture reversed the conversion, which resulted in a decrease in AM-thiol conjugate levels and a concomitant increase in AM levels, whereas addition of NAC led to the formation of AM-NAC and a concomitant decrease in AM-GSH levels.	Sulfhydryl Compounds	211-216	X-linked Kx blood group	Homo sapiens	326-329
22634334-9	2012	Also, curcumin can drastically down-regulate Trx1 protein level as well as its enzyme activity in HeLa cells, which in turn remarkably decreases intracellular free thiols, shifting the intracellular redox balance to a more oxidative state, and subsequently induces DNA oxidative damage.	Sulfhydryl Compounds	164-170	thioredoxin	Homo sapiens	45-49
22738349-3	2012	Furthermore, we demonstrate that the electronic coupling between the QDs and the (MBzA) thiol ligands is influenced by the strength of the Cd-S bond that can be changed by protonating the S atom.	Sulfhydryl Compounds	88-93	CDP-diacylglycerol synthase 1	Homo sapiens	139-143
22003958-2	2012	Altered cellular redox status and redox sensitive thiols contributing to induction of resistance strongly connect the ubiquitous redox enzyme thioredoxin reductase (TrxR) to the cellular response to ionizing radiation.	Sulfhydryl Compounds	50-56	thioredoxin	Homo sapiens	142-153
22396951-3	2012	We designed single polymer nanopores with a hydrophobic gate on one side in the form of a single layer of C10 or C18 thiols.	Sulfhydryl Compounds	117-123	Bardet-Biedl syndrome 9	Homo sapiens	113-116
21938399-5	2012	Methionine synthase activity was constant and independent of thiol concentrations.	Sulfhydryl Compounds	61-66	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
22534037-14	2012	Expression of the oxidoreductase thioredoxin (TRX1), the second major thiol-dependent antioxidant system in eukaryotic cells, was slightly reduced, while the oxygen-sensing protein HIF-1alpha was downregulated in HEMA-exposed cell cultures.	Sulfhydryl Compounds	70-75	thioredoxin 1	Mus musculus	46-50
22609005-2	2012	In previous studies we have demonstrated that smokers have elevated levels of thiocyanate ions (SCN(-)), relative to nonsmokers, and increased thiol oxidation, as SCN(-) is a favored substrate for MPO, and the resulting hypothiocyanous acid (HOSCN) targets thiol groups rapidly and selectively.	Sulfhydryl Compounds	143-148	myeloperoxidase	Homo sapiens	197-200
22609005-2	2012	In previous studies we have demonstrated that smokers have elevated levels of thiocyanate ions (SCN(-)), relative to nonsmokers, and increased thiol oxidation, as SCN(-) is a favored substrate for MPO, and the resulting hypothiocyanous acid (HOSCN) targets thiol groups rapidly and selectively.	Sulfhydryl Compounds	257-262	myeloperoxidase	Homo sapiens	197-200
22807135-2	2012	Nucleophilic thiol-disulfide exchange reactions within the I27 domain of titin were previously investigated with force clamp AFM.	Sulfhydryl Compounds	13-18	titin	Homo sapiens	73-78
22531851-0	2012	Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue.	Sulfhydryl Compounds	59-64	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	31-34
22531851-0	2012	Improving the stability of the EC1 domain of E-cadherin by thiol alkylation of the cysteine residue.	Sulfhydryl Compounds	59-64	cadherin 1	Homo sapiens	45-55
22531851-3	2012	To improve solution stability of the EC1 protein, the thiol group of the Cys13 residue in EC1 was alkylated with iodoacetate, iodoacetamide, and maleimide-PEG-5000 to produce thioether derivatives called EC1-IA, EC1-IN, and EC1-PEG.	Sulfhydryl Compounds	54-59	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	37-40
22531851-3	2012	To improve solution stability of the EC1 protein, the thiol group of the Cys13 residue in EC1 was alkylated with iodoacetate, iodoacetamide, and maleimide-PEG-5000 to produce thioether derivatives called EC1-IA, EC1-IN, and EC1-PEG.	Sulfhydryl Compounds	54-59	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	90-93
22531851-3	2012	To improve solution stability of the EC1 protein, the thiol group of the Cys13 residue in EC1 was alkylated with iodoacetate, iodoacetamide, and maleimide-PEG-5000 to produce thioether derivatives called EC1-IA, EC1-IN, and EC1-PEG.	Sulfhydryl Compounds	54-59	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	90-93
22531851-3	2012	To improve solution stability of the EC1 protein, the thiol group of the Cys13 residue in EC1 was alkylated with iodoacetate, iodoacetamide, and maleimide-PEG-5000 to produce thioether derivatives called EC1-IA, EC1-IN, and EC1-PEG.	Sulfhydryl Compounds	54-59	Susceptibility to lysis by alloreactive natural killer cells	Homo sapiens	90-93
23407461-2	2012	Thioredoxin (TRX) is one of the major components of the thiol reducing system and plays multiple roles in cellular processes.	Sulfhydryl Compounds	56-61	thioredoxin	Homo sapiens	0-11
23407461-2	2012	Thioredoxin (TRX) is one of the major components of the thiol reducing system and plays multiple roles in cellular processes.	Sulfhydryl Compounds	56-61	thioredoxin	Homo sapiens	13-16
22003958-2	2012	Altered cellular redox status and redox sensitive thiols contributing to induction of resistance strongly connect the ubiquitous redox enzyme thioredoxin reductase (TrxR) to the cellular response to ionizing radiation.	Sulfhydryl Compounds	50-56	peroxiredoxin 5	Homo sapiens	165-169
22564487-4	2012	The Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectra (XPS) studies showed that the thiol and amino group participated in the adsorption of Pb(II), Cu(II) and Zn(II).	Sulfhydryl Compounds	113-118	submaxillary gland androgen regulated protein 3B	Homo sapiens	169-175
22354836-3	2012	The ability of electrophilic derivatives to interact with hASBT was evaluated by 2-aminoethyl-methanethiosulfonate (MTSEA)-biotin labeling of thiol groups in TM7 cysteine mutants.	Sulfhydryl Compounds	142-147	solute carrier family 10 member 2	Homo sapiens	58-63
22580993-1	2012	In this paper, we describe a thiol-mediated and energy-dependent membrane transport of selenium by erythroid anion exchanger 1 (AE1, also known as band 3 protein).	Sulfhydryl Compounds	29-34	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	128-131
21945855-0	2012	Thiol redox requirements and substrate specificities of recombinant cytochrome c assembly systems II and III.	Sulfhydryl Compounds	0-5	cytochrome c, somatic	Homo sapiens	68-80
22622685-4	2012	A thiol-modified aptamer against thrombin was immobilized on the FracAu electrode through a self-assembling process.	Sulfhydryl Compounds	2-7	coagulation factor II, thrombin	Homo sapiens	33-41
22587396-7	2012	These results suggest that Trx1 readily undergoes oxidative modification by 1,2-NQ through the proximal thiols Cys32 and Cys35.	Sulfhydryl Compounds	104-110	thioredoxin 1	Mus musculus	27-31
22676268-7	2012	Among the several active cysteine-substitution mutants of LPCAT1 generated, we identified one to be resistant to treatment by sulfhydryl-alkylating and sulfhydryl-oxidizer agents.	Sulfhydryl Compounds	126-136	lysophosphatidylcholine acyltransferase 1	Homo sapiens	58-64
22676268-8	2012	CONCLUSION: Mutant forms of LPCAT1 that are not inhibited by Ca(2+) and sulfhydryl-alkylating and -oxidizing agents will provide a better understanding of the physiological function of a mechanism that places the formation of PC, and the disposal of the bioactive species lysoPC, under the control of the redox status and Ca(2+) concentration of the cell.	Sulfhydryl Compounds	72-82	lysophosphatidylcholine acyltransferase 1	Homo sapiens	28-34
22161819-3	2012	This study was undertaken to determine whether the thiol-sensitive PTP1B is affected by ROS in SSc dermal fibroblasts, thereby enhancing the phosphorylation of PDGFR and synthesis of type I collagen.	Sulfhydryl Compounds	51-56	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	67-72
22161819-3	2012	This study was undertaken to determine whether the thiol-sensitive PTP1B is affected by ROS in SSc dermal fibroblasts, thereby enhancing the phosphorylation of PDGFR and synthesis of type I collagen.	Sulfhydryl Compounds	51-56	platelet derived growth factor receptor beta	Homo sapiens	160-165
22642259-1	2012	A series of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors have been synthesized with either a 3-(mercaptomethyl)benzoic acid or 2-(2-mercaptoethyl)benzoic acid scaffold.	Sulfhydryl Compounds	12-17	folate hydrolase 1	Rattus norvegicus	24-53
22642259-1	2012	A series of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors have been synthesized with either a 3-(mercaptomethyl)benzoic acid or 2-(2-mercaptoethyl)benzoic acid scaffold.	Sulfhydryl Compounds	12-17	folate hydrolase 1	Rattus norvegicus	55-60
22397371-4	2012	Site-directed mutagenesis and cysteine residue substitution, together with a thiol-specific cross-linker, served to show that the VDAC1 N-terminal region exists in a dynamic equilibrium, located within the pore or exposed outside the beta-barrel.	Sulfhydryl Compounds	77-82	voltage dependent anion channel 1	Homo sapiens	130-135
21440604-3	2012	MAJOR CONCLUSIONS: Structural characterization of SNO-proteins by X-ray crystallography is increasingly being utilized to understand both the relationships between protein structure and Cys thiol reactivity as well as the consequences of S-nitrosylation on protein structure and function.	Sulfhydryl Compounds	190-195	strawberry notch homolog 1	Homo sapiens	50-53
22616859-7	2012	Recent studies with HO2 (haem oxygenase-2), a K+ ion channel (the BK channel) and a nuclear receptor (Rev-Erb) demonstrate that this mode of regulation involves a thiol-disulfide redox switch that regulates haem binding and that gas signalling molecules (CO and NO) modulate the effect of haem.	Sulfhydryl Compounds	163-168	heme oxygenase 2	Homo sapiens	20-23
21878369-4	2012	MAJOR CONCLUSIONS: Thioredoxin (Trx) system in mammalian cells utilizes thiol and selenol groups to maintain a reducing intracellular environment to combat oxidative/nitrosative stress.	Sulfhydryl Compounds	72-77	thioredoxin	Homo sapiens	19-30
21878369-4	2012	MAJOR CONCLUSIONS: Thioredoxin (Trx) system in mammalian cells utilizes thiol and selenol groups to maintain a reducing intracellular environment to combat oxidative/nitrosative stress.	Sulfhydryl Compounds	72-77	thioredoxin	Homo sapiens	32-35
22616859-7	2012	Recent studies with HO2 (haem oxygenase-2), a K+ ion channel (the BK channel) and a nuclear receptor (Rev-Erb) demonstrate that this mode of regulation involves a thiol-disulfide redox switch that regulates haem binding and that gas signalling molecules (CO and NO) modulate the effect of haem.	Sulfhydryl Compounds	163-168	heme oxygenase 2	Homo sapiens	25-41
22860208-8	2012	LC/MS analysis of tryptic digests from sol-S-hMGL directly demonstrate covalent modification of this variant by NAM and AM6580, consistent with enzyme thiol alkylation and carbamoylation, respectively.	Sulfhydryl Compounds	151-156	monoglyceride lipase	Homo sapiens	45-49
22514092-4	2012	The reversal of ZmC(4)-NADP-ME oxidation by chemical reductants suggests the presence of thiol groups able to form disulfide bonds.	Sulfhydryl Compounds	89-94	NADP-dependent malic enzyme, chloroplastic	Zea mays	23-30
22283708-0	2012	Feedback inhibition by thiols outranks glutathione depletion: a luciferase-based screen reveals glutathione-deficient gamma-ECS and glutathione synthetase mutants impaired in cadmium-induced sulfate assimilation.	Sulfhydryl Compounds	23-29	glutathione synthetase 2	Arabidopsis thaliana	132-154
22571165-7	2012	Finally, studies with the cysteine protease, papain, suggest that the reduction of sulfinamide to the free thiol is viable in a protein environment.	Sulfhydryl Compounds	107-112	cathepsin B	Homo sapiens	26-43
22860206-5	2012	Here, we examined stimulatory effects of endogenous phospholipids and thiol compounds on recombinant NAAA.	Sulfhydryl Compounds	70-75	N-acylethanolamine acid amidase	Mus musculus	101-105
22402363-11	2012	Free thiol cysteine analogs showed inhibition of IL-8 induction by Ox-PAPC, and both a cysteine analog and a cell surface thiol blocker strongly inhibited ADAM activity induction by Ox-PAPC.	Sulfhydryl Compounds	5-10	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
22624172-9	2004	synthesized an engineered analog of human prothrombin in which the active site was modified by a thrombin inhibitor that possesses a protected thiol group (1, 6).	Sulfhydryl Compounds	143-148	coagulation factor II, thrombin	Homo sapiens	42-53
22624172-9	2004	synthesized an engineered analog of human prothrombin in which the active site was modified by a thrombin inhibitor that possesses a protected thiol group (1, 6).	Sulfhydryl Compounds	143-148	coagulation factor II, thrombin	Homo sapiens	45-53
22624172-10	2004	Thus, the prothrombin analog could react with a thiol-specific Alexa Fluor 680 dye (AF680-ProT) for fluorescence imaging or with diethylenetriamine pentaacetic acid (DTPA) for (64)Cu-labeling ((64)Cu-DTPA-ProT).	Sulfhydryl Compounds	48-53	coagulation factor II, thrombin	Homo sapiens	10-21
22624174-9	2004	synthesized an engineered analog of human prothrombin in which the active site was modified by a thrombin inhibitor that possesses a protected thiol group (1, 6).	Sulfhydryl Compounds	143-148	coagulation factor II, thrombin	Homo sapiens	42-53
22624174-9	2004	synthesized an engineered analog of human prothrombin in which the active site was modified by a thrombin inhibitor that possesses a protected thiol group (1, 6).	Sulfhydryl Compounds	143-148	coagulation factor II, thrombin	Homo sapiens	45-53
22542445-7	2012	Thiol redox proteomics demonstrate that Trx2, Prx3, and Trx1 are among the most sensitive proteins in cells to Cr(VI) treatment.	Sulfhydryl Compounds	0-5	thioredoxin 2	Homo sapiens	40-44
22542445-7	2012	Thiol redox proteomics demonstrate that Trx2, Prx3, and Trx1 are among the most sensitive proteins in cells to Cr(VI) treatment.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	56-60
22533988-2	2012	Here we show the reversible formation of surface electronic trap states in the model system of solid thin films of PbS QDs capped with thiol molecules.	Sulfhydryl Compounds	135-140	cholinergic receptor muscarinic 3	Homo sapiens	115-118
22504937-0	2012	Diaminoterephthalate turn-on fluorescence probes for thiols--tagging of recoverin and tracking of its conformational change.	Sulfhydryl Compounds	53-59	recoverin	Homo sapiens	72-81
22402363-11	2012	Free thiol cysteine analogs showed inhibition of IL-8 induction by Ox-PAPC, and both a cysteine analog and a cell surface thiol blocker strongly inhibited ADAM activity induction by Ox-PAPC.	Sulfhydryl Compounds	5-10	protocadherin 8	Homo sapiens	70-74
22387200-6	2012	ECs treated with GSSG show increased thiol modifications of p65 and also a block in TNFalpha-induced p65 nuclear translocation and ICAM-1 expression, but not in IkappaBalpha degradation.	Sulfhydryl Compounds	37-42	RELA proto-oncogene, NF-kB subunit	Homo sapiens	60-63
22446016-2	2012	Glutathione-S-transferase (GST) catalyses the nucleophilic addition of the thiol of GSH to electrophilic acceptors.	Sulfhydryl Compounds	75-80	glutathione S-transferase kappa 1	Homo sapiens	0-25
22446016-2	2012	Glutathione-S-transferase (GST) catalyses the nucleophilic addition of the thiol of GSH to electrophilic acceptors.	Sulfhydryl Compounds	75-80	glutathione S-transferase kappa 1	Homo sapiens	27-30
22401798-0	2012	Role of thiol pathways in TF procoagulant regulation.	Sulfhydryl Compounds	8-13	coagulation factor III	Mus musculus	26-28
22406319-5	2012	Mass spectrometric analysis of RyR1 exposed in situ to VAS2870 and of VAS2870-treated glutathione indicated that thiol modification is through alkylation by the benzyltriazolopyrimidine moiety of VAS2870.	Sulfhydryl Compounds	113-118	ryanodine receptor 1	Homo sapiens	31-35
22406319-7	2012	In addition, we show that SR-localized Nox4 is inhibited by other thiol-alkylating agents, consistent with a causal role for cysteine modification in the inhibition of ROS production by VAS2870.	Sulfhydryl Compounds	66-71	NADPH oxidase 4	Homo sapiens	39-43
22401853-5	2012	PDI has oxidoreductase, isomerase, and chaperone effects, the last not directly dependent on its thiols.	Sulfhydryl Compounds	97-103	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-3
22401798-4	2012	However, thiol modifying agents, without suppressing phosphatidylserine exposure, can prevent TF activation, implicating thiol-disulfide exchange reactions in the regulation of TF procoagulant activity of primary cells.	Sulfhydryl Compounds	9-14	coagulation factor III	Mus musculus	94-96
22401798-4	2012	However, thiol modifying agents, without suppressing phosphatidylserine exposure, can prevent TF activation, implicating thiol-disulfide exchange reactions in the regulation of TF procoagulant activity of primary cells.	Sulfhydryl Compounds	121-126	coagulation factor III	Mus musculus	177-179
22401798-5	2012	Protein disulfide isomerase (PDI), a regulator of extracellular thiol exchange, is associated with cell surface TF and required for TF-dependent thrombosis in vivo.	Sulfhydryl Compounds	64-69	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	0-27
22401798-5	2012	Protein disulfide isomerase (PDI), a regulator of extracellular thiol exchange, is associated with cell surface TF and required for TF-dependent thrombosis in vivo.	Sulfhydryl Compounds	64-69	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	29-32
22401798-5	2012	Protein disulfide isomerase (PDI), a regulator of extracellular thiol exchange, is associated with cell surface TF and required for TF-dependent thrombosis in vivo.	Sulfhydryl Compounds	64-69	coagulation factor III	Mus musculus	112-114
22401798-6	2012	PDI regulates the thiol-dependent biogenesis of procoagulant microparticles that are released from myeloid cells and smooth muscle cells following activation of the purinergic P2X7 receptor.	Sulfhydryl Compounds	18-23	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	0-3
22401798-6	2012	PDI regulates the thiol-dependent biogenesis of procoagulant microparticles that are released from myeloid cells and smooth muscle cells following activation of the purinergic P2X7 receptor.	Sulfhydryl Compounds	18-23	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	176-189
22465014-8	2012	In addition, clusterin was found to prevent the inactivation of glutamine synthetase (GS) by metal-catalyzed oxidation (MCO) in vitro, and this protection was only supported by thiol-reducing equivalents, such as, DTT or GSH, and not by ascorbate (a non-thiol MCO system).	Sulfhydryl Compounds	177-182	clusterin	Homo sapiens	13-22
22458813-5	2012	In addition, via the use of a tungsten STM tip coated with a tungsten oxide (WO(3)) layer, we selectively catalyzed the adsorption through the thiol group.	Sulfhydryl Compounds	143-148	sulfotransferase family 1A member 3	Homo sapiens	39-42
22465014-8	2012	In addition, clusterin was found to prevent the inactivation of glutamine synthetase (GS) by metal-catalyzed oxidation (MCO) in vitro, and this protection was only supported by thiol-reducing equivalents, such as, DTT or GSH, and not by ascorbate (a non-thiol MCO system).	Sulfhydryl Compounds	177-182	Glutamine synthetase 1	Drosophila melanogaster	64-84
22465014-8	2012	In addition, clusterin was found to prevent the inactivation of glutamine synthetase (GS) by metal-catalyzed oxidation (MCO) in vitro, and this protection was only supported by thiol-reducing equivalents, such as, DTT or GSH, and not by ascorbate (a non-thiol MCO system).	Sulfhydryl Compounds	254-259	clusterin	Homo sapiens	13-22
22465014-8	2012	In addition, clusterin was found to prevent the inactivation of glutamine synthetase (GS) by metal-catalyzed oxidation (MCO) in vitro, and this protection was only supported by thiol-reducing equivalents, such as, DTT or GSH, and not by ascorbate (a non-thiol MCO system).	Sulfhydryl Compounds	254-259	Glutamine synthetase 1	Drosophila melanogaster	64-84
22369897-3	2012	The MARS-115 CatG peptidyl inhibitor containing the 1-aminoalkylphosphonate diaryl ester moiety at the C terminus and N-succinamide with a free carboxylic function was synthesized and covalently immobilized onto the gold chip surface via the thiol group (cysteamine).	Sulfhydryl Compounds	242-247	cathepsin G	Homo sapiens	13-17
22475174-0	2012	Catalytic adaptive recognition of thiol (SH) and selenol (SeH) groups toward synthesis of functionalized vinyl monomers.	Sulfhydryl Compounds	34-39	epoxide hydrolase 2	Homo sapiens	58-61
22589847-2	2012	The S atom acts as a bridge to two neighbouring Pb(II) ions, thereby forming a double thiol-ate chain.	Sulfhydryl Compounds	86-91	submaxillary gland androgen regulated protein 3B	Homo sapiens	48-54
22380866-2	2012	We previously showed that recombinant PON1 is inhibited by linoleic acid hydroperoxide (LA-OOH) present in the lipid fraction of the human carotid plaque (LLE) via oxidation of the enzyme"s Cys284 thiol.	Sulfhydryl Compounds	197-202	paraoxonase 1	Homo sapiens	38-42
22105604-5	2012	Using tandem mass spectrometric analysis, we now have established that the C106 thiol and the C23-C45 disulfide bond are required for HMGB1 to induce nuclear NF-kappaB translocation and tumor necrosis factor (TNF) production in macrophages.	Sulfhydryl Compounds	80-85	high mobility group box 1	Mus musculus	134-139
22248185-6	2012	Furthermore, the titration of free thiols in H2O2-treated L-PGDS revealed that H2O2 reacted with the thiol of Cys65 of L-PGDS.	Sulfhydryl Compounds	35-41	prostaglandin D2 synthase	Homo sapiens	58-64
22248185-6	2012	Furthermore, the titration of free thiols in H2O2-treated L-PGDS revealed that H2O2 reacted with the thiol of Cys65 of L-PGDS.	Sulfhydryl Compounds	35-41	prostaglandin D2 synthase	Homo sapiens	119-125
22248185-6	2012	Furthermore, the titration of free thiols in H2O2-treated L-PGDS revealed that H2O2 reacted with the thiol of Cys65 of L-PGDS.	Sulfhydryl Compounds	35-40	prostaglandin D2 synthase	Homo sapiens	58-64
22248185-6	2012	Furthermore, the titration of free thiols in H2O2-treated L-PGDS revealed that H2O2 reacted with the thiol of Cys65 of L-PGDS.	Sulfhydryl Compounds	35-40	prostaglandin D2 synthase	Homo sapiens	119-125
22248185-7	2012	The MALDI-TOF (matrix-assisted laser-desorption ionization-time-of-flight)-MS spectrum of H2O2-treated L-PGDS showed a 32 Da increase in the mass relative to that of the untreated protein, showing that the thiol was oxidized to sulfinic acid.	Sulfhydryl Compounds	206-211	prostaglandin D2 synthase	Homo sapiens	103-109
22198382-4	2012	Thiol residues of the critical cysteines in Akt are oxidized to a greater degree in mice treated with MPTP, which is reflected as a 40% loss of reduced Akt.	Sulfhydryl Compounds	0-5	thymoma viral proto-oncogene 1	Mus musculus	44-47
22198382-4	2012	Thiol residues of the critical cysteines in Akt are oxidized to a greater degree in mice treated with MPTP, which is reflected as a 40% loss of reduced Akt.	Sulfhydryl Compounds	0-5	thymoma viral proto-oncogene 1	Mus musculus	152-155
22219129-5	2012	With the progression of the disease, increased levels of oxidative insults facilitated the oxidation of thiol groups of cysteine residues; human mutant SOD1 could generate an upper shift band in reducing SDS-PAGE, which turned out to be a Cys111-peroxidized SOD1 species.	Sulfhydryl Compounds	104-109	superoxide dismutase 1	Homo sapiens	152-156
22198382-6	2012	Maintaining the protein thiol homeostasis by thiol antioxidants prevented loss of reduced Akt, decreased association with PP2A, and maintained pAkt levels.	Sulfhydryl Compounds	24-29	thymoma viral proto-oncogene 1	Mus musculus	90-93
22198382-6	2012	Maintaining the protein thiol homeostasis by thiol antioxidants prevented loss of reduced Akt, decreased association with PP2A, and maintained pAkt levels.	Sulfhydryl Compounds	24-29	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	122-126
22198382-6	2012	Maintaining the protein thiol homeostasis by thiol antioxidants prevented loss of reduced Akt, decreased association with PP2A, and maintained pAkt levels.	Sulfhydryl Compounds	45-50	thymoma viral proto-oncogene 1	Mus musculus	90-93
22198382-6	2012	Maintaining the protein thiol homeostasis by thiol antioxidants prevented loss of reduced Akt, decreased association with PP2A, and maintained pAkt levels.	Sulfhydryl Compounds	45-50	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	122-126
22325869-3	2012	This redox modification involves protein thiols and glutathione and is mainly controlled by glutaredoxins, oxidoreductases belonging to the thioredoxin superfamily.	Sulfhydryl Compounds	41-47	thioredoxin	Homo sapiens	140-151
22105604-5	2012	Using tandem mass spectrometric analysis, we now have established that the C106 thiol and the C23-C45 disulfide bond are required for HMGB1 to induce nuclear NF-kappaB translocation and tumor necrosis factor (TNF) production in macrophages.	Sulfhydryl Compounds	80-85	tumor necrosis factor	Mus musculus	186-207
22105604-5	2012	Using tandem mass spectrometric analysis, we now have established that the C106 thiol and the C23-C45 disulfide bond are required for HMGB1 to induce nuclear NF-kappaB translocation and tumor necrosis factor (TNF) production in macrophages.	Sulfhydryl Compounds	80-85	tumor necrosis factor	Mus musculus	209-212
22105604-6	2012	Both irreversible oxidation to sulphonates and complete reduction to thiols of these cysteines inhibited TNF production markedly.	Sulfhydryl Compounds	69-75	tumor necrosis factor	Mus musculus	105-108
22105604-7	2012	In a proof of concept murine model of hepatic necrosis induced by acetaminophen, during inflammation, the predominant form of serum HMGB1 is the active one, containing a C106 thiol group and a disulfide bond between C23 and C45, whereas the inactive form of HMGB1, containing terminally oxidized cysteines, accumulates during inflammation resolution and hepatic regeneration.	Sulfhydryl Compounds	175-180	high mobility group box 1	Mus musculus	132-137
22412017-5	2012	Conversely, upon depletion of thiol substrates and accumulation of oxidized Pdi1p, Ero1p was inactivated by both autonomous oxidation and Pdi1p-mediated oxidation of Ero1p regulatory bonds.	Sulfhydryl Compounds	30-35	peptidyl arginine deiminase 1	Homo sapiens	138-143
22412017-6	2012	Pdi1p responded to the availability of free thiols and the relative levels of reduced and oxidized glutathione in the ER to control Ero1p activity and ensure that cells generate the minimum number of disulfide bonds needed for efficient oxidative protein folding.	Sulfhydryl Compounds	44-50	peptidyl arginine deiminase 1	Homo sapiens	0-5
22293370-7	2012	The bombesin-induced response was effectively reduced by dithiothreitol (thiol-reducing reagent) (0.4 and 1.9 mumol/kg/animal, i.c.v.)	Sulfhydryl Compounds	73-78	gastrin releasing peptide	Homo sapiens	4-12
21954972-3	2012	To protect mitochondria from these sources of oxidative damage, there is an integrated set of thiol systems within the matrix comprising the thioredoxin/peroxiredoxin/methionine sulfoxide reductase pathways and the glutathione/glutathione peroxidase/glutathione-S-transferase/glutaredoxin pathways that in conjunction with protein thiols prevent much of this oxidative damage.	Sulfhydryl Compounds	94-99	thioredoxin	Homo sapiens	141-152
21954972-3	2012	To protect mitochondria from these sources of oxidative damage, there is an integrated set of thiol systems within the matrix comprising the thioredoxin/peroxiredoxin/methionine sulfoxide reductase pathways and the glutathione/glutathione peroxidase/glutathione-S-transferase/glutaredoxin pathways that in conjunction with protein thiols prevent much of this oxidative damage.	Sulfhydryl Compounds	94-99	glutathione S-transferase kappa 1	Homo sapiens	250-275
21954972-3	2012	To protect mitochondria from these sources of oxidative damage, there is an integrated set of thiol systems within the matrix comprising the thioredoxin/peroxiredoxin/methionine sulfoxide reductase pathways and the glutathione/glutathione peroxidase/glutathione-S-transferase/glutaredoxin pathways that in conjunction with protein thiols prevent much of this oxidative damage.	Sulfhydryl Compounds	94-99	glutaredoxin	Homo sapiens	276-288
22406901-10	2012	The decreased free sulfhydryl content of glycinin indicated that the oxidation of free sulfhydryls and the formation of disulfide bonds occurred when the extraction time was prolonged.	Sulfhydryl Compounds	19-29	LOC732636	Glycine max	41-49
22406901-10	2012	The decreased free sulfhydryl content of glycinin indicated that the oxidation of free sulfhydryls and the formation of disulfide bonds occurred when the extraction time was prolonged.	Sulfhydryl Compounds	87-98	LOC732636	Glycine max	41-49
22223263-7	2012	In addition, thiol peptides in protein/peptide enzymatic digests can be quickly and effectively tagged by NPSP following tri-n-butylphosphine (TBP) reduction.	Sulfhydryl Compounds	13-18	TATA-box binding protein	Homo sapiens	143-146
22404931-1	2012	We have used thiol cross-linking and electron paramagnetic resonance (EPR) to resolve structural transitions of myosin"s light chain domain (LCD) and catalytic domain (CD) that are associated with force generation.	Sulfhydryl Compounds	13-18	myosin heavy chain 14	Homo sapiens	112-118
22215680-0	2012	Integrated stress response modulates cellular redox state via induction of cystathionine gamma-lyase: cross-talk between integrated stress response and thiol metabolism.	Sulfhydryl Compounds	152-157	cystathionase (cystathionine gamma-lyase)	Mus musculus	75-100
21850520-0	2012	SNAP-25 contains non-acylated thiol pairs that can form intrachain disulfide bonds: possible sites for redox modulation of neurotransmission.	Sulfhydryl Compounds	30-35	synaptosome associated protein 25	Rattus norvegicus	0-7
21850520-3	2012	We have examined, in rat brain extracts, both the availability of closely spaced, or vicinal, thiol pairs in SNAP-25 and the propensity of these dithiols toward disulfide bond formation using a method improved by us recently that exploits the high chemoselectivity of phenylarsine oxide (PAO) for vicinal thiols.	Sulfhydryl Compounds	94-99	synaptosome associated protein 25	Rattus norvegicus	109-116
21850520-4	2012	The results show for the first time that a substantial fraction of soluble and, to a lesser extent, particulate SNAP-25 contain non-acylated PAO-binding thiol pairs and that these thiols in soluble SNAP-25 in particular have a high propensity toward disulfide bond formation.	Sulfhydryl Compounds	153-158	synaptosome associated protein 25	Rattus norvegicus	112-119
21850520-4	2012	The results show for the first time that a substantial fraction of soluble and, to a lesser extent, particulate SNAP-25 contain non-acylated PAO-binding thiol pairs and that these thiols in soluble SNAP-25 in particular have a high propensity toward disulfide bond formation.	Sulfhydryl Compounds	180-186	synaptosome associated protein 25	Rattus norvegicus	112-119
21850520-4	2012	The results show for the first time that a substantial fraction of soluble and, to a lesser extent, particulate SNAP-25 contain non-acylated PAO-binding thiol pairs and that these thiols in soluble SNAP-25 in particular have a high propensity toward disulfide bond formation.	Sulfhydryl Compounds	180-186	synaptosome associated protein 25	Rattus norvegicus	198-205
21850520-5	2012	Indeed, disulfide bonds were detected in a small fraction of soluble SNAP-25 even under conditions designed to prevent or greatly limit protein thiol oxidation during experimental procedures.	Sulfhydryl Compounds	144-149	synaptosome associated protein 25	Rattus norvegicus	69-76
22214747-3	2012	We have shown previously that the myeloperoxidase (MPO)-derived oxidants HOCl and HOSCN target thiols and mediate cellular dysfunction.	Sulfhydryl Compounds	95-101	myeloperoxidase	Homo sapiens	34-49
22214747-3	2012	We have shown previously that the myeloperoxidase (MPO)-derived oxidants HOCl and HOSCN target thiols and mediate cellular dysfunction.	Sulfhydryl Compounds	95-101	myeloperoxidase	Homo sapiens	51-54
22214747-4	2012	As SERCA contains Cys residues critical to ATPase activity, we hypothesized that HOCl and HOSCN might inhibit SERCA activity, via thiol oxidation, and increase cytosolic Ca(2+) levels in human coronary artery endothelial cells (HCAEC).	Sulfhydryl Compounds	130-135	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	3-8
22214747-4	2012	As SERCA contains Cys residues critical to ATPase activity, we hypothesized that HOCl and HOSCN might inhibit SERCA activity, via thiol oxidation, and increase cytosolic Ca(2+) levels in human coronary artery endothelial cells (HCAEC).	Sulfhydryl Compounds	130-135	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	110-115
22303921-0	2012	Molecular basis of the mechanism of thiol oxidation by hydrogen peroxide in aqueous solution: challenging the SN2 paradigm.	Sulfhydryl Compounds	36-41	solute carrier family 38 member 5	Homo sapiens	110-113
22223263-8	2012	Notably, all three thiols of the peptide QCCASVCSL in the insulin peptic digest can be modified simultaneously by NPSP.	Sulfhydryl Compounds	19-25	insulin	Homo sapiens	58-65
22328155-5	2012	Nonadjacent thiol and thioether groups in MTMT suggest involvement of a chelated metal complex in MOR244-3 activation.	Sulfhydryl Compounds	12-17	olfactory receptor family 4 subfamily E member 2	Mus musculus	98-106
22070883-3	2012	Using miR-122 as an example, we report here the PNA sequence and attached amino acid requirements for efficient miRNA targeting and show that anti-miR activity is enhanced substantially by the presence of a terminal-free thiol group, such as a Cys residue, primarily due to better cellular uptake.	Sulfhydryl Compounds	221-226	microRNA 122	Homo sapiens	6-13
22070883-3	2012	Using miR-122 as an example, we report here the PNA sequence and attached amino acid requirements for efficient miRNA targeting and show that anti-miR activity is enhanced substantially by the presence of a terminal-free thiol group, such as a Cys residue, primarily due to better cellular uptake.	Sulfhydryl Compounds	221-226	membrane associated ring-CH-type finger 8	Homo sapiens	6-9
22328157-5	2012	In situ redox titrations demonstrate that the regulatory thiol groups on gamma(2)-ATP synthase remain reduced under physiological conditions but can be oxidized by the strong oxidant diamide, implying that the redox potential for the thiol/disulphide transition in gamma(2) is substantially higher than that for gamma(1).	Sulfhydryl Compounds	57-62	ATP synthase	Arabidopsis thaliana	82-94
22328157-5	2012	In situ redox titrations demonstrate that the regulatory thiol groups on gamma(2)-ATP synthase remain reduced under physiological conditions but can be oxidized by the strong oxidant diamide, implying that the redox potential for the thiol/disulphide transition in gamma(2) is substantially higher than that for gamma(1).	Sulfhydryl Compounds	234-239	ATP synthase	Arabidopsis thaliana	82-94
22247548-6	2012	The role of thioltransferase and glutathione reductase in the cellular reduction of disulfides and other oxidized forms of thiols was clarified.	Sulfhydryl Compounds	123-129	glutaredoxin	Homo sapiens	12-28
22207754-1	2012	TRPA1 (transient receptor potential ankyrin 1) is an ion channel expressed in the termini of sensory neurons and is activated in response to a broad array of noxious exogenous and endogenous thiol-reactive compounds, making it a crucial player in chemical nociception.	Sulfhydryl Compounds	191-196	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
22207754-1	2012	TRPA1 (transient receptor potential ankyrin 1) is an ion channel expressed in the termini of sensory neurons and is activated in response to a broad array of noxious exogenous and endogenous thiol-reactive compounds, making it a crucial player in chemical nociception.	Sulfhydryl Compounds	191-196	transient receptor potential cation channel subfamily A member 1	Homo sapiens	7-45
22247548-6	2012	The role of thioltransferase and glutathione reductase in the cellular reduction of disulfides and other oxidized forms of thiols was clarified.	Sulfhydryl Compounds	123-129	glutathione-disulfide reductase	Homo sapiens	33-54
22280411-6	2012	The cysteine-myoglobin model retained more sulfhydryl groups than the cysteine-only model (p &lt; 0.05).	Sulfhydryl Compounds	43-53	myoglobin	Homo sapiens	13-22
22147704-3	2012	The oxidized active site cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a locally constrained peroxidase.	Sulfhydryl Compounds	70-75	periaxin	Homo sapiens	91-94
22147704-3	2012	The oxidized active site cysteine of Prx can be reduced by a cellular thiol, thus enabling Prx to function as a locally constrained peroxidase.	Sulfhydryl Compounds	70-75	periaxin	Homo sapiens	37-40
22200491-0	2012	Changes in mitochondrial glutathione levels and protein thiol oxidation in  yfh1 yeast cells and the lymphoblasts of patients with Friedreich"s ataxia.	Sulfhydryl Compounds	56-61	ferroxidase	Saccharomyces cerevisiae S288C	76-80
22061108-0	2012	Maleimide-thiol coupling of a bioactive peptide to an elastin-like protein polymer.	Sulfhydryl Compounds	10-15	nuclear receptor subfamily 5 group A member 1	Homo sapiens	54-74
22239540-1	2012	We herein describe the first synthesis of the native antimicrobial protein HBD-1 making use of an orthogonal thiol protection strategy and a novel dicarba analogue thereof.	Sulfhydryl Compounds	109-114	defensin beta 1	Homo sapiens	75-80
22200491-4	2012	The potential biological consequences of oxidative stress and changes in glutathione levels associated with frataxin deficiency include the oxidation of susceptible protein thiols and reversible binding of glutathione to the SH of proteins by S-glutathionylation.	Sulfhydryl Compounds	173-179	frataxin	Homo sapiens	108-116
22200491-5	2012	In this study, we isolated mitochondria from frataxin-deficient  yfh1 yeast cells and lymphoblasts of FRDA patients, and show evidence for a severe mitochondrial glutathione-dependent oxidative stress, with a low GSH/GSSG ratio, and thiol modifications of key mitochondrial enzymes.	Sulfhydryl Compounds	233-238	frataxin	Homo sapiens	45-53
22014003-4	2012	Among the 62 hits of a screen of ~15 000 thiol-containing fragments, a naphthyl-thiazole-containing molecule was identified that selectively inhibited and labeled the allosteric cysteine in the p10 subunit of caspase-5, but caused very little inhibition or labeling of caspase-1.	Sulfhydryl Compounds	41-46	caspase 5	Homo sapiens	209-218
22095074-11	2012	Pretreatment with the thiol-reducing agents attenuated Akt phosphorylation, Nrf2 activation and HO-1 expression, suggesting that cis-GS may cause thiol modification of an upstream signaling modulator.	Sulfhydryl Compounds	22-27	AKT serine/threonine kinase 1	Homo sapiens	55-58
22095074-11	2012	Pretreatment with the thiol-reducing agents attenuated Akt phosphorylation, Nrf2 activation and HO-1 expression, suggesting that cis-GS may cause thiol modification of an upstream signaling modulator.	Sulfhydryl Compounds	22-27	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
22095074-11	2012	Pretreatment with the thiol-reducing agents attenuated Akt phosphorylation, Nrf2 activation and HO-1 expression, suggesting that cis-GS may cause thiol modification of an upstream signaling modulator.	Sulfhydryl Compounds	22-27	heme oxygenase 1	Homo sapiens	96-100
22014003-4	2012	Among the 62 hits of a screen of ~15 000 thiol-containing fragments, a naphthyl-thiazole-containing molecule was identified that selectively inhibited and labeled the allosteric cysteine in the p10 subunit of caspase-5, but caused very little inhibition or labeling of caspase-1.	Sulfhydryl Compounds	41-46	caspase 1	Homo sapiens	269-278
22085642-0	2012	Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis.	Sulfhydryl Compounds	27-33	Harvey rat sarcoma virus oncogene	Mus musculus	13-17
22109665-2	2012	METHODS: Cys-tagged EGF (cEGF) was labeled with (18)F by coupling the free thiol group of the Cys tag with N-[2-(4-[(18)F]fluorobenzamido)ethyl]maleimide ([(18)F]FBEM) to form [(18)F]FBEM-cEGF.	Sulfhydryl Compounds	75-80	epidermal growth factor	Homo sapiens	20-23
22085642-7	2012	Furthermore, the relevance of thiol oxidation was demonstrated by overexpressing manganese superoxide dismutase, which improved HRas palmitoylation and ERK phosphorylation, while lessening apoptosis in HPHG treated ECs.	Sulfhydryl Compounds	30-35	Harvey rat sarcoma virus oncogene	Mus musculus	128-132
22085642-7	2012	Furthermore, the relevance of thiol oxidation was demonstrated by overexpressing manganese superoxide dismutase, which improved HRas palmitoylation and ERK phosphorylation, while lessening apoptosis in HPHG treated ECs.	Sulfhydryl Compounds	30-35	mitogen-activated protein kinase 1	Mus musculus	152-155
22126412-7	2012	The spatial proximity of active site cysteine residues of thioredoxin to reactive thiol groups on triosephosphate isomerase provides a direct link to the observed deglutathionylation of cysteine 217 in triosephosphate isomerase, thereby reversing the inhibitory effect of S-glutathionylation of triosephosphate isomerase.	Sulfhydryl Compounds	82-87	thioredoxin	Homo sapiens	58-69
22088136-1	2012	The redox-active protein cytochrome b(562) has been engineered to introduce pairs of thiol groups in the form of cysteine residues at specified sites.	Sulfhydryl Compounds	85-90	mitochondrially encoded cytochrome b	Homo sapiens	25-37
22088136-2	2012	Successful STM imaging of the molecules adsorbed on a gold surface indicated that one thiol group controls the orientation of the molecule and that the protein maintains its native form under the experimental conditions.	Sulfhydryl Compounds	86-91	sulfotransferase family 1A member 3	Homo sapiens	11-14
22088136-3	2012	Stable protein-gold STM tip electrical contact was directly observed to form via the second free thiol group in current-voltage and current-distance measurements.	Sulfhydryl Compounds	97-102	sulfotransferase family 1A member 3	Homo sapiens	20-23
22248238-1	2012	INTRODUCTION: Nowadays the "redox hypothesis" is based on the fact that thiol/disulfide couples such as glutathione (GSH/GSSG), cysteine (Cys/CySS) and thioredoxin ((Trx-(SH)2/Trx-SS)) are functionally organized in redox circuits controlled by glutathione pools, thioredoxins and other control nodes, and they are not in equilibrium relative to each other.	Sulfhydryl Compounds	72-77	thioredoxin	Homo sapiens	152-163
22248238-1	2012	INTRODUCTION: Nowadays the "redox hypothesis" is based on the fact that thiol/disulfide couples such as glutathione (GSH/GSSG), cysteine (Cys/CySS) and thioredoxin ((Trx-(SH)2/Trx-SS)) are functionally organized in redox circuits controlled by glutathione pools, thioredoxins and other control nodes, and they are not in equilibrium relative to each other.	Sulfhydryl Compounds	72-77	thioredoxin	Homo sapiens	166-169
22248238-1	2012	INTRODUCTION: Nowadays the "redox hypothesis" is based on the fact that thiol/disulfide couples such as glutathione (GSH/GSSG), cysteine (Cys/CySS) and thioredoxin ((Trx-(SH)2/Trx-SS)) are functionally organized in redox circuits controlled by glutathione pools, thioredoxins and other control nodes, and they are not in equilibrium relative to each other.	Sulfhydryl Compounds	72-77	thioredoxin	Homo sapiens	176-179
22202809-1	2012	Glutathione is a ubiquitous thiol in eukaryotic cells, and its high intracellular ratio of reduced form (GSH) to oxidized form (GSSG) is largely maintained by glutathione reductase (GR) using NADPH as electron donor.	Sulfhydryl Compounds	28-33	glutathione-disulfide reductase	Homo sapiens	182-184
22273684-6	2012	All these data suggested that the CEE results from a partial protection of exogenous thiols against reoxidation.	Sulfhydryl Compounds	85-91	guided entry of tail-anchored proteins factor 4	Homo sapiens	34-37
22134636-5	2012	In this study, we systematically evaluated the effect of Dox-induced ROS on the NF-kappaB pathway in a pediatric acute lymphoblastic leukemia (ALL) cell line by measuring the thiol-based oxidative modifications of redox-sensitive proteins within the pathway.	Sulfhydryl Compounds	175-180	nuclear factor kappa B subunit 1	Homo sapiens	80-89
22100505-6	2012	Furthermore, treatment with the thiol antioxidant NAC (15mM, 24h) was able to significantly protect from drug-induced toxicity and ameliorate GSH oxidation, Trx oxidation, and Trx depletion.	Sulfhydryl Compounds	32-37	synuclein alpha	Homo sapiens	50-53
22100505-6	2012	Furthermore, treatment with the thiol antioxidant NAC (15mM, 24h) was able to significantly protect from drug-induced toxicity and ameliorate GSH oxidation, Trx oxidation, and Trx depletion.	Sulfhydryl Compounds	32-37	thioredoxin	Homo sapiens	157-160
22100505-6	2012	Furthermore, treatment with the thiol antioxidant NAC (15mM, 24h) was able to significantly protect from drug-induced toxicity and ameliorate GSH oxidation, Trx oxidation, and Trx depletion.	Sulfhydryl Compounds	32-37	thioredoxin	Homo sapiens	176-179
22100505-7	2012	These data strongly support the hypothesis that simultaneous inhibition of GSH- and Trx-dependent metabolism is necessary to sensitize human breast and prostate cancer cells to 2DG+17AAG-mediated killing via enhancement of thiol-dependent oxidative stress.	Sulfhydryl Compounds	223-228	thioredoxin	Homo sapiens	84-87
22126412-7	2012	The spatial proximity of active site cysteine residues of thioredoxin to reactive thiol groups on triosephosphate isomerase provides a direct link to the observed deglutathionylation of cysteine 217 in triosephosphate isomerase, thereby reversing the inhibitory effect of S-glutathionylation of triosephosphate isomerase.	Sulfhydryl Compounds	82-87	triosephosphate isomerase 1	Homo sapiens	202-227
22126412-7	2012	The spatial proximity of active site cysteine residues of thioredoxin to reactive thiol groups on triosephosphate isomerase provides a direct link to the observed deglutathionylation of cysteine 217 in triosephosphate isomerase, thereby reversing the inhibitory effect of S-glutathionylation of triosephosphate isomerase.	Sulfhydryl Compounds	82-87	triosephosphate isomerase 1	Homo sapiens	98-123
22126412-7	2012	The spatial proximity of active site cysteine residues of thioredoxin to reactive thiol groups on triosephosphate isomerase provides a direct link to the observed deglutathionylation of cysteine 217 in triosephosphate isomerase, thereby reversing the inhibitory effect of S-glutathionylation of triosephosphate isomerase.	Sulfhydryl Compounds	82-87	triosephosphate isomerase 1	Homo sapiens	202-227
23124252-0	2012	Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance.	Sulfhydryl Compounds	50-55	Peroxiredoxin 3	Drosophila melanogaster	15-19
22100759-4	2012	The inhibitory effect of tellurite on lipoamide dehydrogenase is partially reverted by dithiothreitol indicating the participation of the thiol groups of the enzyme.	Sulfhydryl Compounds	138-143	dihydrolipoamide dehydrogenase	Homo sapiens	38-61
23124252-0	2012	Involvement of Prx3, a Drosophila ortholog of the thiol-dependent peroxidase PRDX3, in age-dependent oxidative stress resistance.	Sulfhydryl Compounds	50-55	peroxiredoxin 3	Homo sapiens	77-82
22236188-1	2012	Peroxiredoxins are thiol-specific antioxidant proteins whose expression is elevated in several cancers.	Sulfhydryl Compounds	19-24	peroxiredoxin 1	Homo sapiens	0-14
23132587-0	2012	Macrophage recognition of thiol-group oxidized cells: recognition of carbohydrate chains by macrophage surface nucleolin as apoptotic cells.	Sulfhydryl Compounds	26-31	nucleolin	Homo sapiens	111-120
23132587-9	2012	These results suggest that thiol group-oxidized cells underwent early apoptosis and were recognized by nucleolin on macrophages as early apoptotic cells.	Sulfhydryl Compounds	27-32	nucleolin	Homo sapiens	103-112
22427735-2	2012	It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite.	Sulfhydryl Compounds	127-132	paraoxonase 1	Homo sapiens	27-40
22427735-2	2012	It has been suggested that paraoxonase-1 (PON1) is a rate-limiting enzyme in the conversion of 2-oxo- clopidogrel to an active thiol metabolite.	Sulfhydryl Compounds	127-132	paraoxonase 1	Homo sapiens	42-46
22523692-6	2012	Lower PON1 activity in CRF patients is associated with low thiol concentration, high CRP, and is beneficially enhanced with vitamin C and flavonoids.	Sulfhydryl Compounds	59-64	paraoxonase 1	Homo sapiens	6-10
22619503-2	2012	In the present work, the size-dependent nanoimmunoresponse of mouse Peyer"s patches (PPs) and immunoglobulin A (IgA) level was investigated using fluorescent thiol-organosilica particles.	Sulfhydryl Compounds	158-163	immunoglobulin heavy constant alpha	Mus musculus	94-116
22619503-5	2012	RESULTS: When compared with the larger particles (745 and 925 nm), oral administration of smaller thiol-organosilica particles (100, 180, and 365 nm) increased the number of CD11b(+) macrophages and IgA(+) cells in the subepithelial domes of the PPs.	Sulfhydryl Compounds	98-103	integrin subunit alpha M	Homo sapiens	174-179
22619503-5	2012	RESULTS: When compared with the larger particles (745 and 925 nm), oral administration of smaller thiol-organosilica particles (100, 180, and 365 nm) increased the number of CD11b(+) macrophages and IgA(+) cells in the subepithelial domes of the PPs.	Sulfhydryl Compounds	98-103	CD79a molecule	Homo sapiens	199-202
22304717-4	2012	Over the past 15 years, tremendous efforts have been made in the discovery of potent GCPII inhibitors, particularly those with phosphorus-, urea- and thiol-based zinc binding groups.	Sulfhydryl Compounds	150-155	folate hydrolase 1	Homo sapiens	85-90
23543871-5	2012	Using an in vitro model, we have found that nitrosation of critical thiols and nitration of tyrosines lead to the activation of membrane receptors such as epithelial growth factor receptor, Src, Ras, and CD63.	Sulfhydryl Compounds	68-74	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	190-193
23543871-5	2012	Using an in vitro model, we have found that nitrosation of critical thiols and nitration of tyrosines lead to the activation of membrane receptors such as epithelial growth factor receptor, Src, Ras, and CD63.	Sulfhydryl Compounds	68-74	CD63 molecule	Homo sapiens	204-208
21997288-1	2012	Continuous 295 nm excitation of whey protein bovine apo-alpha-lactalbumin (apo-bLA) results in an increase of tryptophan fluorescence emission intensity, in a progressive red-shift of tryptophan fluorescence emission, and breakage of disulphide bridges (SS), yielding free thiol groups.	Sulfhydryl Compounds	273-278	lactalbumin alpha	Bos taurus	56-73
22707875-6	2012	The reduction of Cbl(III) by dithiothreitol, which contains two thiols, is much faster even though no stable Cbl(III) complex is formed.	Sulfhydryl Compounds	64-70	Cbl proto-oncogene	Homo sapiens	17-20
21748537-5	2012	RESULTS: UV-exposure of solid human insulin results in photodissociation of the C-terminal intrachain disulfide bond, leading to formation of a CysS( ) thiyl radical pair which ultimately disproportionates into thiol and thioaldehyde species.	Sulfhydryl Compounds	211-216	insulin	Homo sapiens	36-43
22669675-7	2012	Thiol-based redox couples such as GSH/GSSG, cysteine/cystine (cys/cySS), thioredoxin-reduced/thioredoxin-oxidized (TRX(red)/TRX(ox)) form independent signaling nodes that selectively regulate developmental events and are closely linked to changes in intracellular redox potentials.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	115-118
22669675-7	2012	Thiol-based redox couples such as GSH/GSSG, cysteine/cystine (cys/cySS), thioredoxin-reduced/thioredoxin-oxidized (TRX(red)/TRX(ox)) form independent signaling nodes that selectively regulate developmental events and are closely linked to changes in intracellular redox potentials.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	124-127
22792412-4	2012	TRX system is composed of several proteins such as TRX and peroxiredoxin (PRDX), two thiol-containing enzymes that are key players in redox homeostasis due to their ability to scavenge potential harmful reactive oxygen species.	Sulfhydryl Compounds	85-90	thioredoxin	Homo sapiens	0-3
22792412-4	2012	TRX system is composed of several proteins such as TRX and peroxiredoxin (PRDX), two thiol-containing enzymes that are key players in redox homeostasis due to their ability to scavenge potential harmful reactive oxygen species.	Sulfhydryl Compounds	85-90	thioredoxin	Homo sapiens	51-54
23133616-8	2012	Mutant forms of FGF-1 that enhance thermostability or eliminate buried reactive thiols demonstrate a shorter distribution half-life, a longer elimination half-life, and a longer mean residence time (MRT) in comparison to wild-type FGF-1.	Sulfhydryl Compounds	80-86	fibroblast growth factor 1	Homo sapiens	16-21
23133616-8	2012	Mutant forms of FGF-1 that enhance thermostability or eliminate buried reactive thiols demonstrate a shorter distribution half-life, a longer elimination half-life, and a longer mean residence time (MRT) in comparison to wild-type FGF-1.	Sulfhydryl Compounds	80-86	fibroblast growth factor 1	Homo sapiens	231-236
22693631-8	2012	With the help of thiol blocking reagents, a mutational analysis and miRNA mediated knock-down of ISG15 expression, we revealed that this modification occurs in living cells via a disulphide bridge between the substrates and Cys78 in the hinge region of ISG15.	Sulfhydryl Compounds	17-22	ISG15 ubiquitin like modifier	Homo sapiens	97-102
23112811-0	2012	Covalent modification of mutant rat P2X2 receptors with a thiol-reactive fluorophore allows channel activation by zinc or acidic pH without ATP.	Sulfhydryl Compounds	58-63	purinergic receptor P2X 2	Rattus norvegicus	36-40
22905257-7	2012	However, pretreatment of recombinant human STAT3 with NCA or NCP reduced labeling of free sulfhydryl residues.	Sulfhydryl Compounds	90-100	signal transducer and activator of transcription 3	Homo sapiens	43-48
22693631-8	2012	With the help of thiol blocking reagents, a mutational analysis and miRNA mediated knock-down of ISG15 expression, we revealed that this modification occurs in living cells via a disulphide bridge between the substrates and Cys78 in the hinge region of ISG15.	Sulfhydryl Compounds	17-22	ISG15 ubiquitin like modifier	Homo sapiens	253-258
22624030-9	2012	The mapping of the periplasmic surface of an homology model of human AQP3 evidenced the thiol group of Cys40 as a likely candidate for binding to gold(III) complexes.	Sulfhydryl Compounds	88-93	aquaporin 3 (Gill blood group)	Homo sapiens	69-73
22081312-1	2012	We purified to homogeneity and characterized a heat stable thioredoxin which catalyzes thiol/disulfide exchange reaction, for the first time from dromedary pancreas.	Sulfhydryl Compounds	87-92	thioredoxin	Camelus dromedarius	59-70
22558124-7	2012	Available evidence suggests the Nrf2 activators may block Nrf2 ubiquitination by altering Keap1 conformation via reaction with the thiols of specific Keap1 cysteines.	Sulfhydryl Compounds	131-137	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
22558124-7	2012	Available evidence suggests the Nrf2 activators may block Nrf2 ubiquitination by altering Keap1 conformation via reaction with the thiols of specific Keap1 cysteines.	Sulfhydryl Compounds	131-137	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
22558124-7	2012	Available evidence suggests the Nrf2 activators may block Nrf2 ubiquitination by altering Keap1 conformation via reaction with the thiols of specific Keap1 cysteines.	Sulfhydryl Compounds	131-137	kelch like ECH associated protein 1	Homo sapiens	90-95
22558124-7	2012	Available evidence suggests the Nrf2 activators may block Nrf2 ubiquitination by altering Keap1 conformation via reaction with the thiols of specific Keap1 cysteines.	Sulfhydryl Compounds	131-137	kelch like ECH associated protein 1	Homo sapiens	150-155
22523530-2	2012	Redox molecules thioredoxin (Trx) and glutaredoxin (Grx) superfamilies actively maintain intracellular thiol-redox homeostasis by scavenging reactive oxygen species.	Sulfhydryl Compounds	103-108	thioredoxin 1	Mus musculus	16-27
22523530-2	2012	Redox molecules thioredoxin (Trx) and glutaredoxin (Grx) superfamilies actively maintain intracellular thiol-redox homeostasis by scavenging reactive oxygen species.	Sulfhydryl Compounds	103-108	thioredoxin 1	Mus musculus	29-32
22523530-2	2012	Redox molecules thioredoxin (Trx) and glutaredoxin (Grx) superfamilies actively maintain intracellular thiol-redox homeostasis by scavenging reactive oxygen species.	Sulfhydryl Compounds	103-108	glutaredoxin	Mus musculus	38-50
22523530-2	2012	Redox molecules thioredoxin (Trx) and glutaredoxin (Grx) superfamilies actively maintain intracellular thiol-redox homeostasis by scavenging reactive oxygen species.	Sulfhydryl Compounds	103-108	glutaredoxin	Mus musculus	52-55
22299981-2	2012	Here, we describe the etching of gold STM probes suitable for chemical functionalization with moieties bearing thiol groups.	Sulfhydryl Compounds	111-116	sulfotransferase family 1A member 3	Homo sapiens	38-41
22094549-10	2012	Pre-treatment with the antioxidant NAC effectively attenuated neutrophil chemotaxis, elastase release and ROS as well as effectively increased thiol levels in COPD.	Sulfhydryl Compounds	143-148	X-linked Kx blood group	Homo sapiens	35-38
22053983-5	2011	(2) Poly(2-hydroxyethyl-co-2-mercaptoethyl aspartamide) (PHMCA) presenting thiol functional groups was used to link fibronectin to a gold-coated silicon microelectromechanical probe designed to measure cell traction force.	Sulfhydryl Compounds	75-80	fibronectin 1	Homo sapiens	116-127
21569027-6	2011	In girls, visfatin correlated with leptin (r = 0 40, P = 0 009) and thiols (r = -0 36, P = 0 009), which explained 24% in visfatin variability.	Sulfhydryl Compounds	68-74	nicotinamide phosphoribosyltransferase	Homo sapiens	10-18
22144571-9	2011	CONCLUSIONS: We report that Txnrd2 exerts a crucial function during postischemic reperfusion via thiol regeneration.	Sulfhydryl Compounds	97-102	thioredoxin reductase 2	Homo sapiens	28-34
22024594-2	2011	Besides its prominent role as a DNA repair enzyme, APE1 was separately identified as a protein called redox effector factor 1, which is able to enhance the DNA binding activity of several transcription factors through a thiol-exchange-based reduction-oxidation mechanism.	Sulfhydryl Compounds	220-225	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	51-55
21926339-7	2011	Thiol reduction with dithiothreitol increased aerobic force in BPAs and decreased PKG dimerization, VASP phosphorylation, and the contraction to hypoxia.	Sulfhydryl Compounds	0-5	vasodilator stimulated phosphoprotein	Bos taurus	100-104
21755304-3	2011	Altered thiol metabolism from heavy metal toxicity may be responsible for the biochemical alterations in transketolase, and are mechanisms for oxidative stress production, dysautonomia, and abnormal thiamine homeostasis.	Sulfhydryl Compounds	8-13	transketolase	Homo sapiens	105-118
22139372-7	2011	As demonstrated in zebrafish and in a human cellular model for neuronal differentiation, glutaredoxin 2 controls axonal outgrowth via thiol redox regulation of collapsin response mediator protein 2, a central component of the semaphorin pathway.	Sulfhydryl Compounds	134-139	glutaredoxin	Homo sapiens	89-101
21998322-8	2011	To identify the sites of the Hsp90beta modification, we utilized nano-LC/MALDI-TOF MS/MS and suggested that a thiol group on the peptide containing Cys-521 reacted with 6-HITC, resulting in a covalent adduct in a 6-HITC-treated recombinant Hsp90beta in vitro.	Sulfhydryl Compounds	110-115	heat shock protein 90 alpha family class B member 1	Homo sapiens	29-38
21998322-8	2011	To identify the sites of the Hsp90beta modification, we utilized nano-LC/MALDI-TOF MS/MS and suggested that a thiol group on the peptide containing Cys-521 reacted with 6-HITC, resulting in a covalent adduct in a 6-HITC-treated recombinant Hsp90beta in vitro.	Sulfhydryl Compounds	110-115	heat shock protein 90 alpha family class B member 1	Homo sapiens	240-249
22028181-10	2011	Regulation of GK activity through modulation of thiol status may be a physiological regulatory mechanism for the control of GK activity in beta-cells.	Sulfhydryl Compounds	48-53	glucokinase	Mus musculus	14-16
22028181-10	2011	Regulation of GK activity through modulation of thiol status may be a physiological regulatory mechanism for the control of GK activity in beta-cells.	Sulfhydryl Compounds	48-53	glucokinase	Mus musculus	124-126
20686818-9	2011	Additionally, protoapigenone-induced JNK activation was linked to thiol modification of glutathione S-transferase pi (GSTpi), which impeded GSTpi inhibition of JNK.	Sulfhydryl Compounds	66-71	mitogen-activated protein kinase 8	Homo sapiens	37-40
21982895-4	2011	It was found that GSH-quercetin reacts with the thiol N-acetyl-L-cysteine (NAC) to form NAC-quercetin, whereas GSH-monoHER does not react with NAC.	Sulfhydryl Compounds	48-53	X-linked Kx blood group	Homo sapiens	75-78
20686818-9	2011	Additionally, protoapigenone-induced JNK activation was linked to thiol modification of glutathione S-transferase pi (GSTpi), which impeded GSTpi inhibition of JNK.	Sulfhydryl Compounds	66-71	mitogen-activated protein kinase 8	Homo sapiens	160-163
25083217-6	2011	All major drug metabolizing CYP enzymes are capable of converting 2-oxo-clopidogrel to sulfenic acid intermediates that subsequently form the active thiol metabolite.	Sulfhydryl Compounds	149-154	peptidylprolyl isomerase G	Homo sapiens	28-31
22008470-1	2011	BACKGROUND: The paraoxonase activity of the enzyme paraoxonase-1 (PON-1) associated with high-density lipoprotein (HDL) may significantly influence clopidogrel"s antiplatelet and clinical efficacy as a result of its involvement in the clopidogrel biotransformation to the pharmacologically active thiol metabolite.	Sulfhydryl Compounds	297-302	paraoxonase 1	Homo sapiens	51-64
22008470-1	2011	BACKGROUND: The paraoxonase activity of the enzyme paraoxonase-1 (PON-1) associated with high-density lipoprotein (HDL) may significantly influence clopidogrel"s antiplatelet and clinical efficacy as a result of its involvement in the clopidogrel biotransformation to the pharmacologically active thiol metabolite.	Sulfhydryl Compounds	297-302	paraoxonase 1	Homo sapiens	66-71
21936007-5	2011	C3b possesses a thioester domain featuring an internal cycloglutamyl cysteine thioester; upon hydrolysis this yields a free thiol (Cys988) that was also fluorescently tagged.	Sulfhydryl Compounds	124-129	complement C3	Homo sapiens	0-3
22045566-6	2011	We identified specific hydrophobic/aromatic residues required for hepcidin-ferroportin binding and obtained evidence in vitro that a thiol-disulfide interaction between ferroportin C326 and the hepcidin disulfide cage may stabilize binding.	Sulfhydryl Compounds	133-138	hepcidin antimicrobial peptide	Mus musculus	194-202
21946108-1	2011	Thienopyridines (ticlopidine, clopidogrel and prasugrel) are pro-drugs that require metabolism to exhibit a critical thiol group in the active form that binds to the P2Y12 receptor to inhibit platelet activation and prevent thrombus formation in vivo.	Sulfhydryl Compounds	117-122	purinergic receptor P2Y12	Homo sapiens	166-171
21924826-0	2011	Thiol-functionalization of metal-organic framework by a facile coordination-based postsynthetic strategy and enhanced removal of Hg2+ from water.	Sulfhydryl Compounds	0-5	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	129-132
21967605-12	2011	In conclusion, this study suggests that Apc-mutated cells are more efficient than wild-type cells in metabolizing HNE into thiol conjugates and 4-hydroxynonanoic acid due to the higher expression of key biotransformation enzymes.	Sulfhydryl Compounds	123-128	APC regulator of WNT signaling pathway	Homo sapiens	40-43
22118669-0	2011	HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway.	Sulfhydryl Compounds	40-50	heat shock transcription factor 1	Homo sapiens	0-4
22118669-0	2011	HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway.	Sulfhydryl Compounds	40-50	heat shock protein family A (Hsp70) member 4	Homo sapiens	31-36
21945096-1	2011	Manganese superoxide dismutase (SOD2)-mediated adaptive processes that protect against radiation-induced micronucleus formation can be induced in cells after a 2-Gy exposure by previously exposing them to either low-dose ionizing radiation (10cGy) or WR1065 (40muM), the active thiol form of amifostine.	Sulfhydryl Compounds	278-283	superoxide dismutase 2, mitochondrial	Mus musculus	32-36
22118669-0	2011	HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway.	Sulfhydryl Compounds	40-50	kelch like ECH associated protein 1	Homo sapiens	76-81
22118669-0	2011	HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway.	Sulfhydryl Compounds	40-50	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
21945096-3	2011	The goal of this study was the characterization of the effects of TNFalpha receptors 1 and 2 (TNFR1, TNFR2) on the adaptive responses induced by low-dose irradiation or thiol exposure using micronucleus formation as an endpoint.	Sulfhydryl Compounds	169-174	tumor necrosis factor	Mus musculus	66-74
21945096-3	2011	The goal of this study was the characterization of the effects of TNFalpha receptors 1 and 2 (TNFR1, TNFR2) on the adaptive responses induced by low-dose irradiation or thiol exposure using micronucleus formation as an endpoint.	Sulfhydryl Compounds	169-174	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	94-99
21945096-3	2011	The goal of this study was the characterization of the effects of TNFalpha receptors 1 and 2 (TNFR1, TNFR2) on the adaptive responses induced by low-dose irradiation or thiol exposure using micronucleus formation as an endpoint.	Sulfhydryl Compounds	169-174	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	101-106
21945096-9	2011	However, this adaptive effect was completely inhibited if the cells were transfected 24h before low-dose radiation or thiol exposure with SOD2 siRNA.	Sulfhydryl Compounds	118-123	superoxide dismutase 2, mitochondrial	Mus musculus	138-142
22042986-2	2011	Here, we assessed reactivity of intracellularly applied thiol-specific probes with cysteine residues substituted into the 12th transmembrane segment (TM12) of CFTR.	Sulfhydryl Compounds	56-61	CF transmembrane conductance regulator	Homo sapiens	159-163
21992226-2	2011	The architecture of the capsosomes enables a temperature-triggered conversion of oxidized glutathione to its reduced sulfhydryl form by the encapsulated glutathione reductase.	Sulfhydryl Compounds	117-127	glutathione-disulfide reductase	Homo sapiens	153-174
21884783-0	2011	High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase.	Sulfhydryl Compounds	67-72	myeloperoxidase	Homo sapiens	94-109
21884783-2	2011	We hypothesized that smokers would have a high level of thiocyanate (SCN(-)), a preferred substrate for MPO, which in turn would predispose to thiol oxidation, an established independent risk factor for atherosclerosis.	Sulfhydryl Compounds	143-148	myeloperoxidase	Homo sapiens	104-107
21884783-3	2011	In this study it is shown that on exposure to MPO/H(2)O(2), thiols on plasma proteins from nonsmokers were increasingly oxidized with increasing added SCN(-) concentrations.	Sulfhydryl Compounds	60-66	myeloperoxidase	Homo sapiens	46-49
21884783-5	2011	When plasma from smokers and nonsmokers was exposed to MPO/H(2)O(2)-stimulated oxidation, a strong positive correlation (r=0.8139, P&lt;0.0001) between the extent of thiol oxidation and the plasma SCN(-) concentrations was observed.	Sulfhydryl Compounds	166-171	myeloperoxidase	Homo sapiens	55-58
21884783-7	2011	These data indicate that plasma SCN(-) levels are a key determinant of the extent of thiol oxidation on plasma proteins induced by MPO, and implicate HOSCN as an important mediator of inflammation-induced oxidative damage to proteins in smokers.	Sulfhydryl Compounds	85-90	myeloperoxidase	Homo sapiens	131-134
21835919-8	2011	We suggest that Prx IV-L functions as an H(2)O(2) sensor that mediates protein thiol oxidation required for the maturation of spermatozoa in placental mammals.	Sulfhydryl Compounds	79-84	peroxiredoxin 4	Mus musculus	16-22
21911836-3	2011	Fiber formation has been shown to involve thiol/disulfide exchange between VWF molecules.	Sulfhydryl Compounds	42-47	von Willebrand factor	Homo sapiens	75-78
22068231-6	2011	After years of study, ADF proved to be a first human counterpart of thiol-related oxido-reductase thioredoxin/TRX, which opened the field of redox regulation of cell signaling involved in a variety of diseases.	Sulfhydryl Compounds	68-73	thioredoxin	Homo sapiens	22-25
22068231-6	2011	After years of study, ADF proved to be a first human counterpart of thiol-related oxido-reductase thioredoxin/TRX, which opened the field of redox regulation of cell signaling involved in a variety of diseases.	Sulfhydryl Compounds	68-73	thioredoxin	Homo sapiens	98-109
22068231-6	2011	After years of study, ADF proved to be a first human counterpart of thiol-related oxido-reductase thioredoxin/TRX, which opened the field of redox regulation of cell signaling involved in a variety of diseases.	Sulfhydryl Compounds	68-73	thioredoxin	Homo sapiens	110-113
21955842-7	2011	With this background information, the effect of dithionite on the cystines of NP4 and NP7 was studied after trapping of the thiols with para-cloromercurybenzyl sulfonate (p-CMBS) and subsequent matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) where the heterolytic cleavage of the SS bond appears with only 2molar equivalents of the reductant.	Sulfhydryl Compounds	124-130	proteinase 3	Homo sapiens	78-81
21929690-4	2011	Feedback activation of thrombin generation in the presence of platelets was significantly diminished by membrane impermeant thiol blockers or by the thiol isomerase-inhibitors bacitracin and anti-PDI antibody RL90, respectively.	Sulfhydryl Compounds	124-129	coagulation factor II, thrombin	Homo sapiens	23-31
21929690-8	2011	Flow cytometric analysis revealed that membrane impermeant thiol blockers or PDI inhibitors, which had been added after platelet stimulation and after phosphatidylserine exposure to exclude their influence on primary platelet activation, significantly inhibited binding of all coagulation factors to thrombin-stimulated platelets.	Sulfhydryl Compounds	59-64	coagulation factor II, thrombin	Homo sapiens	300-308
22605892-2	2011	Thioredoxins maintain Cys residues in thiol forms, and previous research shows that the redox potential of thioredoxin in mitochondria and nuclei is more reduced than cytoplasm, suggesting that proteins in these compartments may have different steady-state oxidation.	Sulfhydryl Compounds	38-43	thioredoxin	Homo sapiens	107-118
20878652-1	2011	In this paper, we described a strategy for synthesis of thiol-coated CdTe/CdS/ZnS (core-shell-shell) quantum dots (QDs) via aqueous synthesis approach.	Sulfhydryl Compounds	56-61	CDP-diacylglycerol synthase 1	Homo sapiens	74-77
21987804-4	2011	Treatment with diamide, a thiol-oxidizing agent, induced formation of disulfide bonds between R91C residues in adjacent Orai1 subunits and rapidly blocked STIM1-operated Ca(2+) current.	Sulfhydryl Compounds	26-31	ORAI calcium release-activated calcium modulator 1	Homo sapiens	120-125
21987804-4	2011	Treatment with diamide, a thiol-oxidizing agent, induced formation of disulfide bonds between R91C residues in adjacent Orai1 subunits and rapidly blocked STIM1-operated Ca(2+) current.	Sulfhydryl Compounds	26-31	stromal interaction molecule 1	Homo sapiens	155-160
21853977-3	2011	Fibroblast growth factor-2 (FGF2) was immobilized within agarose hydrogels that were modified with two-photon labile 6-bromo-7-hydroxycoumarin-protected thiols.	Sulfhydryl Compounds	153-159	fibroblast growth factor 2	Homo sapiens	0-26
21294652-7	2011	The antioxidant response occurs in both regenerating fibers and leukocytes that express high levels of free thiols and antioxidant enzymes, such as superoxide dismutase 1 (SOD1) and thioredoxin.	Sulfhydryl Compounds	108-114	superoxide dismutase 1	Homo sapiens	148-170
21294652-7	2011	The antioxidant response occurs in both regenerating fibers and leukocytes that express high levels of free thiols and antioxidant enzymes, such as superoxide dismutase 1 (SOD1) and thioredoxin.	Sulfhydryl Compounds	108-114	superoxide dismutase 1	Homo sapiens	172-176
21294652-8	2011	HMGB1, a protein thiol, weakly expressed in healthy muscles, increases during regeneration in parallel with the antioxidant response in both fibers and leukocytes.	Sulfhydryl Compounds	17-22	high mobility group box 1	Homo sapiens	0-5
21853977-3	2011	Fibroblast growth factor-2 (FGF2) was immobilized within agarose hydrogels that were modified with two-photon labile 6-bromo-7-hydroxycoumarin-protected thiols.	Sulfhydryl Compounds	153-159	fibroblast growth factor 2	Homo sapiens	28-32
21615675-6	2011	On the other hand, thiol antioxidant N-acetylcysteine or glutamate receptor antagonist D-AP5 also partially alleviates MPP(+) -induced mitochondrial fragmentation, suggesting a vicious spiral of events contributes to MPP(+) -induced toxicity.	Sulfhydryl Compounds	19-24	adaptor related protein complex 5 subunit beta 1	Homo sapiens	89-92
21812471-1	2011	A bienzymatic electrode incorporating trehalase (Tre) and glucose oxidase (GOx) covalently bound to the surface of Pt through a functionalized thiol linker (Tre GOx Pt) has been designed and assembled and its catalytic properties examined by chemical and electrochemical methods in aqueous phosphate buffer solutions (PBS, pH 7.4).	Sulfhydryl Compounds	143-148	trehalase	Homo sapiens	38-47
21936800-3	2011	We outline the complexity of the role of protein thiol-disulfide oxidoreduction in the regulation of immunity and inflammation, the underlying molecular mechanisms (such as protein glutathionylation) and the key enzyme players such as Trx (thioredoxin) or Grx (glutaredoxin).	Sulfhydryl Compounds	49-54	thioredoxin	Homo sapiens	235-238
21812471-1	2011	A bienzymatic electrode incorporating trehalase (Tre) and glucose oxidase (GOx) covalently bound to the surface of Pt through a functionalized thiol linker (Tre GOx Pt) has been designed and assembled and its catalytic properties examined by chemical and electrochemical methods in aqueous phosphate buffer solutions (PBS, pH 7.4).	Sulfhydryl Compounds	143-148	hydroxyacid oxidase 1	Homo sapiens	58-73
21812471-1	2011	A bienzymatic electrode incorporating trehalase (Tre) and glucose oxidase (GOx) covalently bound to the surface of Pt through a functionalized thiol linker (Tre GOx Pt) has been designed and assembled and its catalytic properties examined by chemical and electrochemical methods in aqueous phosphate buffer solutions (PBS, pH 7.4).	Sulfhydryl Compounds	143-148	hydroxyacid oxidase 1	Homo sapiens	75-78
21812471-1	2011	A bienzymatic electrode incorporating trehalase (Tre) and glucose oxidase (GOx) covalently bound to the surface of Pt through a functionalized thiol linker (Tre GOx Pt) has been designed and assembled and its catalytic properties examined by chemical and electrochemical methods in aqueous phosphate buffer solutions (PBS, pH 7.4).	Sulfhydryl Compounds	143-148	trehalase	Homo sapiens	157-160
21936800-3	2011	We outline the complexity of the role of protein thiol-disulfide oxidoreduction in the regulation of immunity and inflammation, the underlying molecular mechanisms (such as protein glutathionylation) and the key enzyme players such as Trx (thioredoxin) or Grx (glutaredoxin).	Sulfhydryl Compounds	49-54	thioredoxin	Homo sapiens	240-251
21936800-3	2011	We outline the complexity of the role of protein thiol-disulfide oxidoreduction in the regulation of immunity and inflammation, the underlying molecular mechanisms (such as protein glutathionylation) and the key enzyme players such as Trx (thioredoxin) or Grx (glutaredoxin).	Sulfhydryl Compounds	49-54	glutaredoxin	Homo sapiens	256-259
21936800-3	2011	We outline the complexity of the role of protein thiol-disulfide oxidoreduction in the regulation of immunity and inflammation, the underlying molecular mechanisms (such as protein glutathionylation) and the key enzyme players such as Trx (thioredoxin) or Grx (glutaredoxin).	Sulfhydryl Compounds	49-54	glutaredoxin	Homo sapiens	261-273
21921133-3	2011	In contrast with previous assays that do not possess adequate sensitivity for optimal screening, herein is reported a high-throughput assay that uses an alternative thiol-releasing substrate, S-methyl-L-thiocitrulline, and a thiol-reactive fluorophore, 7-diethylamino-3-(4"-maleimidylphenyl)-4-methylcoumarin, to enable continuous detection of product formation by DDAH-1.	Sulfhydryl Compounds	165-170	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	365-371
22279244-1	2011	Competitive adsorption of three human plasma proteins: albumin (HSA), fibrinogen (Fgn), and immunoglobulin G (IgG) from their ternary solution mixtures onto a sulfhydryl-to-sulfonate gradient surface was investigated using spatially-resolved total internal reflection fluorescence (TIRF) and autoradiography.	Sulfhydryl Compounds	159-170	fibrinogen beta chain	Homo sapiens	82-85
21781009-4	2011	Cellular uptake of NO from E-Mono-SNO-HSA partly takes place via low molecular weight thiol, and it results in cytoprotective effects by induction of heme oxygenase-1.	Sulfhydryl Compounds	86-91	strawberry notch homolog 1	Homo sapiens	34-37
21844013-6	2011	The thiol antioxidant (N-acetylcysteine, NAC) was capable of protecting cancer cells from 2DG + carboplatin -induced cell killing.	Sulfhydryl Compounds	4-9	synuclein alpha	Homo sapiens	41-44
21844013-11	2011	CONCLUSIONS: These results show in vitro and in vivo that simultaneous inhibition of GSH and Trx metabolism can effectively inhibit lung cancer cell growth and induce chemosensitization by a mechanism that involves thiol-mediated oxidative stress.	Sulfhydryl Compounds	215-220	thioredoxin	Homo sapiens	93-96
21890659-4	2011	The loss of HLA-E expression following selenite treatment was associated with decreased levels of intracellular free thiols in the tumor cells, suggesting that the reduced HLA-E protein synthesis was caused by oxidative stress.	Sulfhydryl Compounds	117-123	major histocompatibility complex, class I, E	Homo sapiens	12-17
21921133-3	2011	In contrast with previous assays that do not possess adequate sensitivity for optimal screening, herein is reported a high-throughput assay that uses an alternative thiol-releasing substrate, S-methyl-L-thiocitrulline, and a thiol-reactive fluorophore, 7-diethylamino-3-(4"-maleimidylphenyl)-4-methylcoumarin, to enable continuous detection of product formation by DDAH-1.	Sulfhydryl Compounds	225-230	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	365-371
21828038-8	2011	Interestingly, consistent with the thiol modification mechanism for Top2alpha cleavage complex induction, the thiol-reactive selenocysteine, but not the non-thiol-reactive selenomethionine, was shown to induce Top2alpha cleavage complexes.	Sulfhydryl Compounds	35-40	DNA topoisomerase II alpha	Homo sapiens	68-77
21791574-2	2011	Given that selective ENT1 inhibitors, such as nitrobenzylmercaptopurine riboside (NBMPR), bind to the N-terminal half of the ENT1 protein, we hypothesized that one or more of the four cysteine residues in this region were contributing to the effects of the sulfhydryl modifiers.	Sulfhydryl Compounds	257-267	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	125-129
22260071-0	2011	[Construction of gold film solid-phase carrier of myoglobin monoclonal antibody based on thiol self-assembly].	Sulfhydryl Compounds	89-94	myoglobin	Homo sapiens	50-59
21828038-8	2011	Interestingly, consistent with the thiol modification mechanism for Top2alpha cleavage complex induction, the thiol-reactive selenocysteine, but not the non-thiol-reactive selenomethionine, was shown to induce Top2alpha cleavage complexes.	Sulfhydryl Compounds	110-115	DNA topoisomerase II alpha	Homo sapiens	68-77
21828038-8	2011	Interestingly, consistent with the thiol modification mechanism for Top2alpha cleavage complex induction, the thiol-reactive selenocysteine, but not the non-thiol-reactive selenomethionine, was shown to induce Top2alpha cleavage complexes.	Sulfhydryl Compounds	110-115	DNA topoisomerase II alpha	Homo sapiens	210-219
21791598-9	2011	In whole neutrophils, immunoprecipitation and colocalization experiments demonstrated PDI association with membrane complex subunits and prominent thiol-mediated interaction with p47(phox) in the cytosol fraction.	Sulfhydryl Compounds	147-152	pleckstrin	Homo sapiens	179-182
22400346-3	2011	A covalent functionalization on Si or Cu surfaces requires the molecules to be differently modified: thiol (-SH) or C double bond C terminations are respectively suitable for Cu or H-Si(100).	Sulfhydryl Compounds	101-106	aldo-keto reductase family 1 member B10	Homo sapiens	181-185
21828038-8	2011	Interestingly, consistent with the thiol modification mechanism for Top2alpha cleavage complex induction, the thiol-reactive selenocysteine, but not the non-thiol-reactive selenomethionine, was shown to induce Top2alpha cleavage complexes.	Sulfhydryl Compounds	110-115	DNA topoisomerase II alpha	Homo sapiens	68-77
21946612-7	2011	Our results illustrate the importance of crystal edges and grain boundaries in interface chemistry and have broad implications for the application of thiol-based SAMs, ranging from nanomechanical sensors to coating technologies.	Sulfhydryl Compounds	150-155	methionine adenosyltransferase 1A	Homo sapiens	162-166
21828038-8	2011	Interestingly, consistent with the thiol modification mechanism for Top2alpha cleavage complex induction, the thiol-reactive selenocysteine, but not the non-thiol-reactive selenomethionine, was shown to induce Top2alpha cleavage complexes.	Sulfhydryl Compounds	110-115	DNA topoisomerase II alpha	Homo sapiens	210-219
21828038-9	2011	In the aggregate, our results suggest that thiol modification of Top2alpha may contribute to apoptosis induction in transformed cells by ITCs.	Sulfhydryl Compounds	43-48	DNA topoisomerase II alpha	Homo sapiens	65-74
21811734-0	2011	A general model of metal underpotential deposition in the presence of thiol-based additives based on an in situ STM study.	Sulfhydryl Compounds	70-75	sulfotransferase family 1A member 3	Homo sapiens	112-115
21896730-4	2011	Thus, Nox4 is an O(2) sensor in skeletal muscle, and O(2)-coupled hydrogen peroxide production by Nox4 governs the redox state of regulatory RyR1 thiols and thereby governs muscle performance.	Sulfhydryl Compounds	146-152	NADPH oxidase 4	Homo sapiens	98-102
21896730-4	2011	Thus, Nox4 is an O(2) sensor in skeletal muscle, and O(2)-coupled hydrogen peroxide production by Nox4 governs the redox state of regulatory RyR1 thiols and thereby governs muscle performance.	Sulfhydryl Compounds	146-152	ryanodine receptor 1	Homo sapiens	141-145
21768113-4	2011	Labeling of HCVpp envelope proteins with EZ-Link maleimide-PEG2-biotin (maleimide-biotin) detected free thiol groups in both E1 and E2.	Sulfhydryl Compounds	104-109	small nucleolar RNA, H/ACA box 73A	Homo sapiens	125-134
21768113-9	2011	These results suggest that HCV entry is dependent on the presence of free thiol groups in E1 and E2 prior to cellular attachment and reveals a new essential component of the HCV entry process.	Sulfhydryl Compounds	74-79	small nucleolar RNA, H/ACA box 73A	Homo sapiens	90-99
21830773-9	2011	However, NAC pre-exposure restored the redox equilibrium of the cells and the concentration of thiol levels to control values.	Sulfhydryl Compounds	95-100	synuclein alpha	Homo sapiens	9-12
21816192-1	2011	We have previously demonstrated that in Ova-immunized mice the increase in intra-macrophage thiol pool induced by pro-GSH molecules modulates the Th1/Th2 balance in favour of a Th1-type immune response.	Sulfhydryl Compounds	92-97	negative elongation factor complex member C/D, Th1l	Mus musculus	146-149
21816192-1	2011	We have previously demonstrated that in Ova-immunized mice the increase in intra-macrophage thiol pool induced by pro-GSH molecules modulates the Th1/Th2 balance in favour of a Th1-type immune response.	Sulfhydryl Compounds	92-97	heart and neural crest derivatives expressed 2	Mus musculus	150-153
21816192-1	2011	We have previously demonstrated that in Ova-immunized mice the increase in intra-macrophage thiol pool induced by pro-GSH molecules modulates the Th1/Th2 balance in favour of a Th1-type immune response.	Sulfhydryl Compounds	92-97	negative elongation factor complex member C/D, Th1l	Mus musculus	177-180
21893046-12	2011	We conclude that the thiol alkylator NEM can stabilize the gemcitabine-induced conformational change of RRM1, and this stabilized RRM1 conformation has the potential to serve as a specific biomarker of gemcitabine"s therapeutic efficacy.	Sulfhydryl Compounds	21-26	ribonucleotide reductase catalytic subunit M1	Homo sapiens	104-108
21834525-2	2011	Accordingly, organisms have evolved molecular systems, including antioxidant metalloenzymes (such as superoxide dismutase and catalase) and an array of thiol-based redox couples, to neutralize this threat to the cell when it occurs.	Sulfhydryl Compounds	152-157	catalase	Homo sapiens	126-134
21945747-2	2011	METHODS: PEG crosslinking of decellularized aortic valves were completed via a Michael-type addition reaction, followed by covalent incorporation of VEGF through another Michael-type addition reaction between the unsaturated propylene acyl of PEG and the thiol groups on cysteine residues of VEGF.	Sulfhydryl Compounds	255-260	vascular endothelial growth factor A	Homo sapiens	149-153
21620382-6	2011	However, when thiol was used as an acceptor, only a stereoselective addition at C-3 resulted, so as to form C-1, C-3 dithio-substituted 2-deoxypyranosides.	Sulfhydryl Compounds	14-19	complement C3	Homo sapiens	80-83
21620382-6	2011	However, when thiol was used as an acceptor, only a stereoselective addition at C-3 resulted, so as to form C-1, C-3 dithio-substituted 2-deoxypyranosides.	Sulfhydryl Compounds	14-19	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	108-116
21618459-2	2011	We recently described the novel observation that beta2 GPI may exist in healthy individuals in a free thiol (biochemically reduced) form.	Sulfhydryl Compounds	102-107	apolipoprotein H	Homo sapiens	49-58
21618459-4	2011	METHODS: In a retrospective multicenter analysis, the proportion of beta2 GPI with free thiols in serum from healthy volunteers was quantified.	Sulfhydryl Compounds	88-94	apolipoprotein H	Homo sapiens	68-77
21618459-8	2011	CONCLUSION: This large retrospective multicenter study shows that posttranslational modification of beta2 GPI via thiol-exchange reactions is a highly specific phenomenon in the setting of APS thrombosis.	Sulfhydryl Compounds	114-119	apolipoprotein H	Homo sapiens	100-109
22117450-12	2011	It is not excluded that the amidoderivatives studied prevent platelet aggregation by a modification of the critical thiol group in the purine receptor P2Y12.	Sulfhydryl Compounds	116-121	purinergic receptor P2Y12	Homo sapiens	151-156
21812108-3	2011	This review focuses on the effects of acrolein on thioredoxin reductase (TrxR) and thioredoxin (Trx), which are major regulators of intracellular protein thiol redox balance.	Sulfhydryl Compounds	154-159	peroxiredoxin 5	Homo sapiens	50-71
21812108-3	2011	This review focuses on the effects of acrolein on thioredoxin reductase (TrxR) and thioredoxin (Trx), which are major regulators of intracellular protein thiol redox balance.	Sulfhydryl Compounds	154-159	peroxiredoxin 5	Homo sapiens	73-77
21812108-3	2011	This review focuses on the effects of acrolein on thioredoxin reductase (TrxR) and thioredoxin (Trx), which are major regulators of intracellular protein thiol redox balance.	Sulfhydryl Compounds	154-159	thioredoxin	Homo sapiens	50-61
21812108-3	2011	This review focuses on the effects of acrolein on thioredoxin reductase (TrxR) and thioredoxin (Trx), which are major regulators of intracellular protein thiol redox balance.	Sulfhydryl Compounds	154-159	thioredoxin	Homo sapiens	73-76
21884982-2	2011	Here, we show that the thiol-dependent peroxiredoxin Tsa1 and its partner sulfiredoxin, Srx1, are required for CR to extend the replicative life span of yeast cells.	Sulfhydryl Compounds	23-28	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	53-57
21884982-2	2011	Here, we show that the thiol-dependent peroxiredoxin Tsa1 and its partner sulfiredoxin, Srx1, are required for CR to extend the replicative life span of yeast cells.	Sulfhydryl Compounds	23-28	sulfiredoxin	Saccharomyces cerevisiae S288C	88-92
21642840-6	2011	Treatment with N-acetyl-L-cysteine, a thiol-containing antioxidant completely blocked combined treatment-induced Bax translocation as well as DR5 upregulation.	Sulfhydryl Compounds	38-43	BCL2-associated X protein	Mus musculus	113-116
21642840-6	2011	Treatment with N-acetyl-L-cysteine, a thiol-containing antioxidant completely blocked combined treatment-induced Bax translocation as well as DR5 upregulation.	Sulfhydryl Compounds	38-43	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	142-145
21834794-4	2011	These properties include prozyme regulation of AdoMetDC (S-adenosylmethionine decarboxylase) activity in trypanosomatids, co-expression of ODC (ornithine decarboxylase) and AdoMetDC activities in a single protein in plasmodia, and formation of trypanothione, a unique compound linking polyamine and thiol metabolism in trypanosomatids.	Sulfhydryl Compounds	299-304	ornithine decarboxylase 1	Homo sapiens	144-167
21778880-0	2011	Thiol pathways in the regulation of tissue factor prothrombotic activity.	Sulfhydryl Compounds	0-5	coagulation factor III, tissue factor	Homo sapiens	36-49
21778880-2	2011	Whereas TF procoagulant activation, or decryption, is closely associated with the exposure of procoagulant phosphatidylserine in the outer leaflet of cell membranes, thiol pathways and protein disulfide isomerase (PDI) play increasingly recognized roles in regulating TF prothrombotic pathways.	Sulfhydryl Compounds	166-171	coagulation factor III, tissue factor	Homo sapiens	8-10
21480235-3	2011	Moreover, the degree of oxidation of (34) Cys in HSA purified from the HD patients" plasma correlated with the thiol content in plasma.	Sulfhydryl Compounds	111-116	albumin	Homo sapiens	49-52
21844361-4	2011	Here we demonstrate that Cdk5 is activated by S-nitrosylation or reaction of nitric oxide (NO)-related species with the thiol groups of cysteine residues 83 and 157, to form SNO-Cdk5.	Sulfhydryl Compounds	120-125	cyclin dependent kinase 5	Homo sapiens	25-29
21766873-2	2011	In this work, we demonstrate that the electrostatic and chemical (complexing and gold-thiol bonding) interactions existing in a gold nanoparticle/Zn(2+)/dithiothreitol-based ternary chemical system is "programmable" and can be utilized to regulate the aggregation and dispersion of nanoparticles via XOR and INHIBIT logics.	Sulfhydryl Compounds	86-91	xanthine dehydrogenase	Homo sapiens	300-303
21786322-4	2011	We previously demonstrated that the glycolytic enzyme triosephosphate isomerase from G. lamblia (GlTIM), could be completely inactivated by low micromolar concentrations of thiol-reactive compounds, whereas, in the same conditions, the activity of human TIM (HuTIM) was almost unaltered.	Sulfhydryl Compounds	173-178	triosephosphate isomerase 1	Homo sapiens	54-79
21786322-4	2011	We previously demonstrated that the glycolytic enzyme triosephosphate isomerase from G. lamblia (GlTIM), could be completely inactivated by low micromolar concentrations of thiol-reactive compounds, whereas, in the same conditions, the activity of human TIM (HuTIM) was almost unaltered.	Sulfhydryl Compounds	173-178	triosephosphate isomerase 1	Homo sapiens	99-102
21755988-0	2011	Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.	Sulfhydryl Compounds	122-127	heat shock protein family A (Hsp70) member 4	Homo sapiens	84-89
21755988-0	2011	Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft.	Sulfhydryl Compounds	122-127	thioredoxin	Homo sapiens	101-112
21755988-6	2011	Previous work has shown that apo-nNOS can be activated by thiol-disulfide exchange, and we show substantial activation with a small molecule dithiol modeled on the active motifs of thioredoxin and protein disulfide isomerase.	Sulfhydryl Compounds	58-63	nitric oxide synthase 1	Homo sapiens	33-37
21755988-6	2011	Previous work has shown that apo-nNOS can be activated by thiol-disulfide exchange, and we show substantial activation with a small molecule dithiol modeled on the active motifs of thioredoxin and protein disulfide isomerase.	Sulfhydryl Compounds	58-63	thioredoxin	Homo sapiens	181-192
21666221-10	2011	Thus, eNOS protein radical formation provides the basis for a mechanism of superoxide-directed regulation of eNOS, involving thiol oxidation, defining a unique pathway for the redox regulation of cardiovascular function.	Sulfhydryl Compounds	125-130	nitric oxide synthase 3	Homo sapiens	6-10
21666221-10	2011	Thus, eNOS protein radical formation provides the basis for a mechanism of superoxide-directed regulation of eNOS, involving thiol oxidation, defining a unique pathway for the redox regulation of cardiovascular function.	Sulfhydryl Compounds	125-130	nitric oxide synthase 3	Homo sapiens	109-113
21851636-5	2011	RESULTS: The association of diabetes and cigarette smoke in DSPP group caused altered glycemia at term, reduced number of implantation and live fetuses, decreased litter and maternal weight, increased pre and postimplantation loss rates, reduced triglyceride and VLDL-c concentrations, increased levels of thiol groups and MDA.	Sulfhydryl Compounds	306-311	dentin sialophosphoprotein	Rattus norvegicus	60-64
21844361-4	2011	Here we demonstrate that Cdk5 is activated by S-nitrosylation or reaction of nitric oxide (NO)-related species with the thiol groups of cysteine residues 83 and 157, to form SNO-Cdk5.	Sulfhydryl Compounds	120-125	cyclin dependent kinase 5	Homo sapiens	178-182
21972493-4	2011	Recent studies demonstrate that increasing thiol-sinks in transgenic plants by overexpressing the bacterial gamma-glutamylcysteine synthetase (ECS) gene results in a higher tolerance and accumulation of metals and metalloids such as cadmium, mercury, and arsenic.	Sulfhydryl Compounds	43-48	glutamate-cysteine ligase catalytic subunit	Homo sapiens	108-141
21595632-7	2011	HgCl2 is a very efficient activator of cellular TF and activating concentrations of HgCl2-mediated oxidation of the reduced Cys(186) and Cys(209) thiols of soluble TF.	Sulfhydryl Compounds	146-152	coagulation factor III, tissue factor	Homo sapiens	164-166
21602054-8	2011	An increased expression of cell-surface thiols, intracellular glutathione, and thioredoxins was also noted in IL-15 cultured T cells.	Sulfhydryl Compounds	40-46	interleukin 15	Homo sapiens	110-115
21703357-6	2011	NO-mediated thiol modification in Keap1 has also been proposed as a possible mechanism of Nrf2 activation.	Sulfhydryl Compounds	12-17	Kelch-like ECH-associated protein 1	Rattus norvegicus	34-39
21638158-1	2011	The design, synthesis, and characterization of an unsymmetrical diamidato-dithiol ligand (H(4) 1, where the hydrogen atoms represent deprotonatable amide and thiol protons) and its cobalt(III) complex, a synthetic analogue of the cobalt-containing nitrile hydratase enzyme family, are reported.	Sulfhydryl Compounds	76-81	CDV3 homolog	Homo sapiens	82-96
21625408-1	2011	207Pb NMR spectroscopy can be used to monitor the binding of Pb(II) to thiol rich biological small molecules such as glutathione and to zinc finger proteins.	Sulfhydryl Compounds	71-76	submaxillary gland androgen regulated protein 3B	Homo sapiens	61-67
21703357-6	2011	NO-mediated thiol modification in Keap1 has also been proposed as a possible mechanism of Nrf2 activation.	Sulfhydryl Compounds	12-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	90-94
21746906-5	2011	Mass spectrometric analysis of purified SR-BI showed two of its six exoplasmic cysteines have free thiol groups (Cys251 and Cys384).	Sulfhydryl Compounds	99-104	scavenger receptor class B member 1	Homo sapiens	40-45
21508882-7	2011	These results indicate that the CTNS gene is actively regulated at the transcriptional and posttranscriptional levels and suggest that CTNS plays a pivotal role in regulating cell thiol concentrations.	Sulfhydryl Compounds	180-185	cystinosin, lysosomal cystine transporter	Homo sapiens	32-36
21508882-7	2011	These results indicate that the CTNS gene is actively regulated at the transcriptional and posttranscriptional levels and suggest that CTNS plays a pivotal role in regulating cell thiol concentrations.	Sulfhydryl Compounds	180-185	cystinosin, lysosomal cystine transporter	Homo sapiens	135-139
21772270-3	2011	Here we outline the shape of the ion pathway of ASIC1 in the open and closed conformations by measuring apparent rates of cysteine modification by thiol-specific reagents in the two transmembrane helices that form the pore (TM1 and TM2).	Sulfhydryl Compounds	147-152	acid sensing ion channel subunit 1	Homo sapiens	48-53
21629912-7	2011	This study reveals that both the selenol or thiol moiety and proline residues are essential for ACE inhibition.	Sulfhydryl Compounds	44-49	angiotensin I converting enzyme	Homo sapiens	96-99
21629922-2	2011	Nucleophiles such as amines, alkoxides, thiols and Grignard reagents all reacted with the 1,3-diphenylbenzotriazinone 6 regioselectively at C-6, while halogenating agents reacted exclusively at C-8.	Sulfhydryl Compounds	40-46	complement C6	Homo sapiens	140-143
21629922-2	2011	Nucleophiles such as amines, alkoxides, thiols and Grignard reagents all reacted with the 1,3-diphenylbenzotriazinone 6 regioselectively at C-6, while halogenating agents reacted exclusively at C-8.	Sulfhydryl Compounds	40-46	homeobox C8	Homo sapiens	194-197
21756336-8	2011	RESULTS: Cyclopalladated complex interacts with thiol groups on the mitochondrial membrane proteins, causes dissipation of the mitochondrial membrane potential, and induces Bax translocation from the cytosol to mitochondria, colocalizing with a mitochondrial tracker.	Sulfhydryl Compounds	48-53	BCL2-associated X protein	Mus musculus	173-176
21586569-6	2011	Additionally, we showed that the same residues involved in coordinating GMQ responses are also critical for activation of the ASIC3(E79C) mutant by thiol-reactive compound DTNB.	Sulfhydryl Compounds	148-153	acid sensing ion channel subunit 3	Homo sapiens	126-131
21586569-6	2011	Additionally, we showed that the same residues involved in coordinating GMQ responses are also critical for activation of the ASIC3(E79C) mutant by thiol-reactive compound DTNB.	Sulfhydryl Compounds	148-153	dystrobrevin beta	Homo sapiens	172-176
21643578-3	2011	During synthesis, GOx molecules interact with Pd salt leading to metal ion and FAD reduction probably via the thiol group of the cysteine 521 residue.	Sulfhydryl Compounds	110-115	hydroxyacid oxidase 1	Homo sapiens	18-21
21254838-3	2011	Significant changes to the abundant and widely distributed redox sensitive thiol proteins were observed in A431 epidermoid carcinoma cells exposed to hydrogen peroxide, but no changes were observed following treatment with epidermal growth factor (EGF).	Sulfhydryl Compounds	75-80	epidermal growth factor	Homo sapiens	248-251
21546426-6	2011	At the hospitalization moment, both GGT and ceruloplasmin were significantly negatively correlated with non-proteic thiols (r = -0.44, P = 0.049, and r = -0.53, P = 0.015, respectively) and significantly positively with protein carbonyls (r = +0.80, P &lt; 0.001, and r = +0.69, P &lt; 0.001, respectively) suggesting putative roles of GGT and ceruloplasmin in the redox imbalance.	Sulfhydryl Compounds	116-122	inactive glutathione hydrolase 2	Homo sapiens	36-39
21546426-6	2011	At the hospitalization moment, both GGT and ceruloplasmin were significantly negatively correlated with non-proteic thiols (r = -0.44, P = 0.049, and r = -0.53, P = 0.015, respectively) and significantly positively with protein carbonyls (r = +0.80, P &lt; 0.001, and r = +0.69, P &lt; 0.001, respectively) suggesting putative roles of GGT and ceruloplasmin in the redox imbalance.	Sulfhydryl Compounds	116-122	ceruloplasmin	Homo sapiens	44-57
21525429-9	2011	Our data show that oxidation of the thiol group of Cys242 and leucine zipper-mediated interaction among the MG53 molecules both contribute to the nucleation process for MG53-mediated cell membrane repair.	Sulfhydryl Compounds	36-41	tripartite motif containing 72	Homo sapiens	108-112
21525429-9	2011	Our data show that oxidation of the thiol group of Cys242 and leucine zipper-mediated interaction among the MG53 molecules both contribute to the nucleation process for MG53-mediated cell membrane repair.	Sulfhydryl Compounds	36-41	tripartite motif containing 72	Homo sapiens	169-173
21466852-1	2011	Peroxiredoxins (Prx"s) are a family of peroxidases that maintain thiol homeostasis by catalyzing the reduction of organic hydroperoxides, H2O2, and peroxynitrite.	Sulfhydryl Compounds	65-70	periaxin	Homo sapiens	16-19
20552295-6	2011	These results are discussed in relation with the known contribution of Grx system to the thiol status during the germination of Cd-poisoned pea seeds.	Sulfhydryl Compounds	89-94	glutaredoxin	Homo sapiens	71-74
21793854-4	2011	Sulforaphane is an electrophile that can react with protein thiols to form thionoacyl adducts and is believed to affect the Cys residues in Keap1 protein.	Sulfhydryl Compounds	60-66	kelch like ECH associated protein 1	Homo sapiens	140-145
21670495-5	2011	The generation of prothrombotic MPs required P2X7 receptor-dependent production of ROS leading to increased availability of solvent-accessible extracellular thiols.	Sulfhydryl Compounds	157-163	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	45-58
21781264-5	2011	The majority of circulating beta2GPI exists in a form containing unpaired cysteines (free thiols), which constitutes the reduced form of beta2GPI.	Sulfhydryl Compounds	90-96	apolipoprotein H	Homo sapiens	28-36
21673709-2	2011	Combining fluorescence microscopy, proteomics, and mass spectrometry, the investigators identified keratins K5 and K14, particularly cysteine 54 of K5, in the human basal epidermal layer as the major molecular targets of caged thiol-reactive fluorescent haptens (i.e., bromobimanes).	Sulfhydryl Compounds	227-232	keratin 14	Homo sapiens	115-118
21781264-5	2011	The majority of circulating beta2GPI exists in a form containing unpaired cysteines (free thiols), which constitutes the reduced form of beta2GPI.	Sulfhydryl Compounds	90-96	apolipoprotein H	Homo sapiens	137-145
21781264-6	2011	The free thiols exposed on beta2GPI are involved in the interaction with platelets and endothelial cells.	Sulfhydryl Compounds	9-15	apolipoprotein H	Homo sapiens	27-35
21595454-0	2011	In situ STM evidence for the adsorption geometry of three N-heteroaromatic thiols on Au(111).	Sulfhydryl Compounds	75-81	sulfotransferase family 1A member 3	Homo sapiens	8-11
21215647-6	2011	This assumption is consistent with the molecular modelling of the complex of psammaplin A thiol with h-HDAC8.	Sulfhydryl Compounds	90-95	histone deacetylase 8	Homo sapiens	103-108
21574592-8	2011	When the energetics of the thiol additions were calculated with several popular density functional theory and ab initio methods (B3LYP, MPW1PW91, B1B95, PBE0, B2PLYP, and MP2), some substantial inaccuracies were noted.	Sulfhydryl Compounds	27-32	tryptase pseudogene 1	Homo sapiens	171-174
21161974-1	2011	We introduce here a simple approach in which a cyclodextrin, functionalized with thiols in the narrower rim, is assembled onto the silver surface of a SERS platform composed of polystyrene beads coated with silver nanoparticles.	Sulfhydryl Compounds	81-87	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	151-155
21507408-3	2011	Thiol groups of beta-Lg underwent a dynamic sulfhydryl/disulfide exchange that is probably essential in accomplishing specific physiological requirements in which proteins may alternatively act either as a trigger or as a target.	Sulfhydryl Compounds	0-5	beta-lactoglobulin	Bubalus bubalis	16-23
21507408-3	2011	Thiol groups of beta-Lg underwent a dynamic sulfhydryl/disulfide exchange that is probably essential in accomplishing specific physiological requirements in which proteins may alternatively act either as a trigger or as a target.	Sulfhydryl Compounds	44-54	beta-lactoglobulin	Bubalus bubalis	16-23
21838416-0	2011	Age-dependent increase in thiol conjugated forms of transthyretin (TTR) in the elderly: quantitative analyses by the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) protein chip system.	Sulfhydryl Compounds	26-31	transthyretin	Homo sapiens	52-65
21838416-0	2011	Age-dependent increase in thiol conjugated forms of transthyretin (TTR) in the elderly: quantitative analyses by the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) protein chip system.	Sulfhydryl Compounds	26-31	transthyretin	Homo sapiens	67-70
21478306-7	2011	Characterization of the enzymatic properties of Str3p confirmed it to be a pyridoxal-5"-phosphate-dependent cystathionine beta-lyase, and we demonstrated that this enzyme was able to cleave the cysteinylated precursors of 3MH and 4MMP to release the free thiols.	Sulfhydryl Compounds	255-261	cystathionine beta-lyase STR3	Saccharomyces cerevisiae S288C	48-53
21420927-3	2011	As a working model for the first step, oxidation of the N-methyl group to N-methoxyl, tropine and a cytochrome P450 monooxygenase reaction centre composed of a truncated heme with sulfhydryl as the axial ligand were used.	Sulfhydryl Compounds	180-190	cytochrome P450 family 20 subfamily A member 1	Homo sapiens	100-129
21481187-7	2011	Here, we show, by MALDI-TOF/TOF MS, a direct interaction of bacitracin with PDI, involving disulfide bond formation between an open thiol form of the bacitracin thiazoline ring and cysteines in the substrate-binding domain of PDI.	Sulfhydryl Compounds	132-137	prolyl 4-hydroxylase subunit beta	Homo sapiens	76-79
21273243-9	2011	The progressive alterations in RyR2 function and Ca(2+) cycling in HF myocytes were associated with sequential modifications of RyR2 by CaMKII-dependent phosphorylation and thiol oxidation.	Sulfhydryl Compounds	173-178	ryanodine receptor 2	Canis lupus familiaris	31-35
21273243-9	2011	The progressive alterations in RyR2 function and Ca(2+) cycling in HF myocytes were associated with sequential modifications of RyR2 by CaMKII-dependent phosphorylation and thiol oxidation.	Sulfhydryl Compounds	173-178	ryanodine receptor 2	Canis lupus familiaris	128-132
21248051-13	2011	CONCLUSION: These results demonstrate that the dimerization of sGC is exquisitely sensitive to thiol reductants compared with that of PKG, which may provide a novel mechanism for thiol-dependent modulation of NO-mediated vasodilatation in conditions such as hypoxia.	Sulfhydryl Compounds	179-184	protein kinase cGMP-dependent 1	Homo sapiens	134-137
21692080-1	2011	Extra-thiol groups on the alpha-subunit allow haptoglobin (Hp) to form a variety of native multimers which influence the biophysical and biological properties of Hp.	Sulfhydryl Compounds	6-11	haptoglobin	Homo sapiens	46-57
21150701-1	2011	STUDY DESIGN: Biomechanical, in vitro, and initial in vivo evaluation of a thiol-modified hyaluronan (TM-HA) and elastin-like polypeptide (ELP) composite hydrogel for nucleus pulposus (NP) tissue engineering.	Sulfhydryl Compounds	75-80	nuclear receptor subfamily 5 group A member 1	Homo sapiens	139-142
21514635-0	2011	Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2.	Sulfhydryl Compounds	0-5	NFE2 like bZIP transcription factor 2	Homo sapiens	135-178
21514635-3	2011	We hypothesized that Nrf2 activation and function would be impaired in severe asthma, resulting in depletion of thiol pools and insufficient glutathione synthesis and conjugation.	Sulfhydryl Compounds	112-117	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
21514635-7	2011	Although Nrf2 mRNA and protein increased in severe asthma as a function of increased thiol oxidation, the Nrf2 expressed was highly dysfunctional.	Sulfhydryl Compounds	85-90	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
21514635-10	2011	CONCLUSION: Children with severe asthma have a global disruption of thiol redox signaling and control in both the airways and systemic circulation that is associated with posttranslational modification of Nrf2.	Sulfhydryl Compounds	68-73	NFE2 like bZIP transcription factor 2	Homo sapiens	205-209
21235483-8	2011	Using signal Cys mutations and thiol-specific probes, we found the C-terminus of YajC was cytoplasmic, while the N-terminus of YajC was buried in the membrane.	Sulfhydryl Compounds	31-36	hypothetical protein	Escherichia coli	81-85
21397009-2	2011	The mitochondrial intermembrane space (IMS) Cu,Zn-superoxide dismutase (SOD1) is activated after oxidative modification of its critical thiol moieties by superoxide anion (O2( -)).	Sulfhydryl Compounds	136-141	superoxide dismutase 1	Homo sapiens	72-76
21576497-3	2011	Here we localize the ATP-binding sites by creating, through a proximity-dependent "tethering" reaction, covalent bonds between a synthesized ATP-derived thiol-reactive P2X2 agonist (NCS-ATP) and single cysteine mutants engineered in the putative binding cavities of the P2X2 receptor.	Sulfhydryl Compounds	153-158	purinergic receptor P2X 2	Homo sapiens	270-274
21300145-8	2011	Preincubation of cells with thiol-containing compounds (NAC and GSH) inhibited the caspase 3 activity triggered by AAI, but non-thiol Tiron did not show a similar effect.	Sulfhydryl Compounds	28-33	X-linked Kx blood group	Homo sapiens	56-59
21300145-8	2011	Preincubation of cells with thiol-containing compounds (NAC and GSH) inhibited the caspase 3 activity triggered by AAI, but non-thiol Tiron did not show a similar effect.	Sulfhydryl Compounds	28-33	caspase 3	Homo sapiens	83-92
21338592-7	2011	In vitro enzyme activity assays indicate that human ALDH7A1 is sensitive to oxidation and that efficiency can be at least partially restored by incubating recombinant protein with the thiol reducing agent beta-mercaptoethanol (BME).	Sulfhydryl Compounds	184-189	aldehyde dehydrogenase 7 family member A1	Homo sapiens	52-59
21443269-6	2011	However, a previous study indicates that the reactivity of AFs and illudin S with glutathione reductase, a thiol-containing enzyme, is inversely correlated with the reactivity toward small molecule thiols.	Sulfhydryl Compounds	107-112	glutathione-disulfide reductase	Homo sapiens	82-103
21454520-3	2011	Arsenic trioxide, a drug for patients with acute promyelocytic leukemia, is found to target and degrade a class of proteins with high levels of cysteine residues and vicinal thiol groups, such as promyelocytic leukemia protein (PML) and PML-retinoic acid receptor alpha fusion protein.	Sulfhydryl Compounds	174-179	PML nuclear body scaffold	Homo sapiens	196-226
21443269-6	2011	However, a previous study indicates that the reactivity of AFs and illudin S with glutathione reductase, a thiol-containing enzyme, is inversely correlated with the reactivity toward small molecule thiols.	Sulfhydryl Compounds	198-204	glutathione-disulfide reductase	Homo sapiens	82-103
21449565-0	2011	4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.	Sulfhydryl Compounds	36-41	sirtuin 3	Mus musculus	26-31
21449565-8	2011	The results of this study characterize altered mitochondrial protein acetylation in a mouse model of chronic ethanol ingestion and thiol-specific allosteric inhibition of rSIRT3 resulting from 4-HNE adduction.	Sulfhydryl Compounds	131-136	sirtuin 3	Rattus norvegicus	171-177
21576497-3	2011	Here we localize the ATP-binding sites by creating, through a proximity-dependent "tethering" reaction, covalent bonds between a synthesized ATP-derived thiol-reactive P2X2 agonist (NCS-ATP) and single cysteine mutants engineered in the putative binding cavities of the P2X2 receptor.	Sulfhydryl Compounds	153-158	purinergic receptor P2X 2	Homo sapiens	168-172
21686078-4	2011	TA-G1-COOH has a thioctic acid moiety, which is a 5-member ring containing a disulfide group that cleaves to produce two anchoring thiols to bond with the gold surface.	Sulfhydryl Compounds	131-137	contactin 2	Homo sapiens	0-5
21472183-1	2011	Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)(3)-chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities.	Sulfhydryl Compounds	32-38	POU class 5 homeobox 1	Homo sapiens	71-80
21420846-0	2011	Electrochemical detection of celiac disease-related anti-tissue transglutaminase antibodies using thiol based surface chemistry.	Sulfhydryl Compounds	98-103	transglutaminase 2	Homo sapiens	57-80
21373697-2	2011	The copper(II)-XO ensemble was highly selective for thiol species such as cysteine, homocysteine, and glutathione without interference from other amino acids and could quantitatively detect thiol in the range from 10 to 200 muM with a linear relationship having an average molar absorbance constant of 6530 L mol(-1) cm(-1) in pure water.	Sulfhydryl Compounds	52-57	latexin	Homo sapiens	224-227
21373697-2	2011	The copper(II)-XO ensemble was highly selective for thiol species such as cysteine, homocysteine, and glutathione without interference from other amino acids and could quantitatively detect thiol in the range from 10 to 200 muM with a linear relationship having an average molar absorbance constant of 6530 L mol(-1) cm(-1) in pure water.	Sulfhydryl Compounds	190-195	latexin	Homo sapiens	224-227
21428695-6	2011	Membrane-bound MGST1 is activated through the thiol modification in oxidative conditions.	Sulfhydryl Compounds	46-51	microsomal glutathione S-transferase 1	Homo sapiens	15-20
21424268-7	2011	These observations may indicate that an isomerisation reaction occurred, catalyzed by the reduced PDI active site, to achieve the thiol-disulphide exchange, i.e. the rearrangement of disulphide bonds between CCCs and keratin.	Sulfhydryl Compounds	130-135	prolyl 4-hydroxylase subunit beta	Homo sapiens	98-101
21142608-9	2011	Our results strongly support a protective role for S100A8 in allergic inflammation by modulating MC activation and eosinophil recruitment, and by scavenging oxidants generated by activated leukocytes, in processes reliant on its thiol-scavenging capacity.	Sulfhydryl Compounds	229-234	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	51-57
21246260-2	2011	Thioredoxin-1 (TRX-1) is a cytosolic thiol antioxidant and redox-active protein which plays a vital role in the maintenance of reduced intracellular redox state.	Sulfhydryl Compounds	37-42	thioredoxin 1	Rattus norvegicus	0-13
21540553-6	2011	N-acetyl-cysteine (NAC), an antioxidant that restores intracellular glutathione (GSH) concentrations, prevented the IL-6-induced inhibitory effect on D1- and D2-mediated T3 production, which suggests that IL-6 might function by depleting an intracellular thiol cofactor, perhaps GSH.	Sulfhydryl Compounds	255-260	interleukin 6	Homo sapiens	116-120
21461940-5	2011	All of these investigations indicated that Cd2+ can directly affect MPT at two separate localization sites at different concentrations: the classic Ca2+ triggering site and the thiol (-SH) groups of membrane proteins matched by MPT pore opening (defined as "S" site).	Sulfhydryl Compounds	177-182	Cd2 molecule	Rattus norvegicus	43-46
21472523-2	2011	The discovery of cysteine-targeting compounds that cause re-activation of mutant p53 and the death of tumor cells in vivo has emphasized the functional importance of p53 thiols.	Sulfhydryl Compounds	170-176	tumor protein p53	Homo sapiens	166-169
21780454-3	2011	QDs with carboxyl functional group have been conjugated to thiol-modified oligo nucleotides, which have been used as a hybridization probe for p53 gene.	Sulfhydryl Compounds	59-64	tumor protein p53	Homo sapiens	143-146
21246260-2	2011	Thioredoxin-1 (TRX-1) is a cytosolic thiol antioxidant and redox-active protein which plays a vital role in the maintenance of reduced intracellular redox state.	Sulfhydryl Compounds	37-42	thioredoxin 1	Rattus norvegicus	15-20
21387053-1	2011	Here we report an example of a mixed thiol monolayer on the surface of Ag nanoparticles which promotes adsorption and quantitative SERS detection of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"); the thiols in the mixed monolayers act synergistically since MDMA does not adsorb onto colloids modified with either of the thiols separately.	Sulfhydryl Compounds	326-332	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	131-135
21525301-4	2011	We use a thiol-reactive methane thiosulfonate (MTS) reagent to modify a conformationally sensitive cysteine residue to demonstrate that hSERT spends more time in an outward facing conformation when transporting DA than when transporting 5-HT.	Sulfhydryl Compounds	9-14	solute carrier family 6 member 4	Homo sapiens	136-141
21387053-0	2011	Modification of Ag nanoparticles with mixed thiols for improved SERS detection of poorly adsorbing target molecules: detection of MDMA.	Sulfhydryl Compounds	44-50	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	64-68
21387055-0	2011	Ionic liquid catalysed reaction of thiols with alpha,beta-unsaturated carbonyl compounds--remarkable influence of the C-2 hydrogen and the anion.	Sulfhydryl Compounds	35-41	complement C2	Homo sapiens	118-121
21387053-1	2011	Here we report an example of a mixed thiol monolayer on the surface of Ag nanoparticles which promotes adsorption and quantitative SERS detection of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"); the thiols in the mixed monolayers act synergistically since MDMA does not adsorb onto colloids modified with either of the thiols separately.	Sulfhydryl Compounds	37-42	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	131-135
21387053-1	2011	Here we report an example of a mixed thiol monolayer on the surface of Ag nanoparticles which promotes adsorption and quantitative SERS detection of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy"); the thiols in the mixed monolayers act synergistically since MDMA does not adsorb onto colloids modified with either of the thiols separately.	Sulfhydryl Compounds	206-212	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	131-135
21387055-1	2011	Hydrogen bond induced reactivity and selectivity control in the 1-butyl-3-methylimidazolium based ionic liquid catalysed reaction of thiols with alpha,beta-unsaturated carbonyl compounds is reported with remarkable influence of the anion and the C-2 hydrogen in catalytic activity and reversal of selectivity.	Sulfhydryl Compounds	133-139	complement C2	Homo sapiens	246-249
21355628-5	2011	The kinetics of burial of the C42 thiol of monellin was observed to follow biexponential kinetics.	Sulfhydryl Compounds	34-39	CDK5 regulatory subunit associated protein 1	Homo sapiens	30-33
20868292-3	2011	In order to cycle back to the reduced state, many peroxiredoxins rely on thiol-dependent reduction by the ubiquitous antioxidant enzyme thioredoxin.	Sulfhydryl Compounds	73-78	thioredoxin	Homo sapiens	136-147
21384861-3	2011	In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ.	Sulfhydryl Compounds	155-161	kelch-like ECH-associated protein 1	Mus musculus	79-84
21384861-3	2011	In studies using 1,2-naphthoquinone (1,2-NQ) as a model quinone, we found that Keap1, the negative regulator of Nrf2, was readily arylated at its reactive thiols by 1,2-NQ.	Sulfhydryl Compounds	155-161	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
21464290-5	2011	Thus, thiolated EphA5-Fc receptor and ephrinA5-Fc ligand were conjugated into PEG hydrogels via a thiol-acrylate photopolymerization to render an otherwise inert PEG hydrogel bioactive.	Sulfhydryl Compounds	6-11	Eph receptor A5	Mus musculus	16-21
21464290-5	2011	Thus, thiolated EphA5-Fc receptor and ephrinA5-Fc ligand were conjugated into PEG hydrogels via a thiol-acrylate photopolymerization to render an otherwise inert PEG hydrogel bioactive.	Sulfhydryl Compounds	6-11	Fc receptor	Mus musculus	22-33
21266572-6	2011	Activation of hPLCbeta3 by U73122 required covalent modification of cysteines as evidenced by the observation that enzyme activation was attenuated by thiol-containing nucleophiles, l-cysteine and glutathione.	Sulfhydryl Compounds	151-156	phospholipase C beta 3	Homo sapiens	14-23
21267493-0	2011	Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF.	Sulfhydryl Compounds	16-21	cathepsin B	Homo sapiens	63-74
21238616-8	2011	These data indicate that PDI and PDIp can perform thiol-disulfide exchange reactions with native disulfide bonds in unfolded RNase via formation of stable disulfide-linked complexes, and from these complexes RNase is further released.	Sulfhydryl Compounds	50-55	prolyl 4-hydroxylase subunit beta	Homo sapiens	25-28
21238616-8	2011	These data indicate that PDI and PDIp can perform thiol-disulfide exchange reactions with native disulfide bonds in unfolded RNase via formation of stable disulfide-linked complexes, and from these complexes RNase is further released.	Sulfhydryl Compounds	50-55	protein disulfide isomerase family A member 2	Homo sapiens	33-37
21572655-1	2011	Clopidogrel is a prodrug which requires cytochrome P450 2C19 (CYP 2C19) enzyme for its conversion to an active thiol metabolite.	Sulfhydryl Compounds	111-116	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	40-60
21572655-1	2011	Clopidogrel is a prodrug which requires cytochrome P450 2C19 (CYP 2C19) enzyme for its conversion to an active thiol metabolite.	Sulfhydryl Compounds	111-116	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	62-70
21078588-5	2011	Finally, we assess some problems inherent to activation of TRPA1 by the reaction of electrophilic compounds with the nucleophilic thiol sink of N-terminal reactive cysteines.	Sulfhydryl Compounds	130-135	transient receptor potential cation channel subfamily A member 1	Homo sapiens	59-64
21448434-2	2011	We examined the thiol sensitivity of IDE using S-nitrosoglutathione, reduced glutathione, and oxidized glutathione to distinguish the effects of nitric oxide from that of the redox state.	Sulfhydryl Compounds	16-21	insulin degrading enzyme	Rattus norvegicus	37-40
21337541-1	2011	N-acetyl-L-cysteine (NAC) is a thiol antioxidant that stimulates glutathione synthesis in cells.	Sulfhydryl Compounds	31-36	X-linked Kx blood group	Homo sapiens	21-24
21242306-4	2011	Exposure of U2OS osteosarcoma cells with low levels of intrinsic ROS to hydrogen peroxide (H(2)O(2)) induces thiol-reversible disulfide bond-mediated oligomerization of NS.	Sulfhydryl Compounds	109-114	G protein nucleolar 3	Homo sapiens	169-171
21267493-2	2011	They show selectivity for inhibition of the thiol-dependent cysteine protease cathepsin B and the histone acetyltransferase p300/CBP associated factor (PCAF) based on their substitution pattern.	Sulfhydryl Compounds	44-49	cathepsin B	Homo sapiens	78-89
21267493-2	2011	They show selectivity for inhibition of the thiol-dependent cysteine protease cathepsin B and the histone acetyltransferase p300/CBP associated factor (PCAF) based on their substitution pattern.	Sulfhydryl Compounds	44-49	E1A binding protein p300	Homo sapiens	98-128
21267493-2	2011	They show selectivity for inhibition of the thiol-dependent cysteine protease cathepsin B and the histone acetyltransferase p300/CBP associated factor (PCAF) based on their substitution pattern.	Sulfhydryl Compounds	44-49	lysine acetyltransferase 2B	Homo sapiens	152-156
21206961-7	2011	Besides, our calculations reveal that the model with 1:2 Au(ad)/thiols ratio, i.e. MeS -Au(ad)-MeS , is energetically preferred compared to the clean and 1:1 ratio models, in agreement with the experimental and theoretical evidences.	Sulfhydryl Compounds	64-70	MKS transition zone complex subunit 1	Homo sapiens	83-86
21216410-1	2011	We have conjugated chloroquine, an anti-malarial, antiviral and anti-tumor drug, with thiol-functionalized gold nanoparticles and studied their binding interaction with bovine serum albumin (BSA) protein.	Sulfhydryl Compounds	86-91	albumin	Homo sapiens	176-189
20626317-7	2011	In eukaryotes, thiol-based switches control the yeast Yap1p transcription factor, the Nrf2/Keap1 electrophile and oxidative stress response, and the Chlamydomonas NAB1 translational repressor.	Sulfhydryl Compounds	15-20	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	54-59
20626317-7	2011	In eukaryotes, thiol-based switches control the yeast Yap1p transcription factor, the Nrf2/Keap1 electrophile and oxidative stress response, and the Chlamydomonas NAB1 translational repressor.	Sulfhydryl Compounds	15-20	mRNA-binding protein NPL3	Saccharomyces cerevisiae S288C	163-167
20812781-5	2011	We review recent results that define a mechanism for how thiol/disulfide redox switches that control heme binding can regulate the activities of an enzyme, heme oxygenase-2, and an ion channel, the BK potassium channel.	Sulfhydryl Compounds	57-62	heme oxygenase 2	Homo sapiens	156-172
21206961-7	2011	Besides, our calculations reveal that the model with 1:2 Au(ad)/thiols ratio, i.e. MeS -Au(ad)-MeS , is energetically preferred compared to the clean and 1:1 ratio models, in agreement with the experimental and theoretical evidences.	Sulfhydryl Compounds	64-70	MKS transition zone complex subunit 1	Homo sapiens	95-98
20978134-2	2011	VKOR is an integral membrane protein that reduces vitamin K using membrane-embedded thiols (Cys-132 and Cys-135), which become oxidized with concomitant VKOR inactivation.	Sulfhydryl Compounds	84-90	vitamin K epoxide reductase complex subunit 1	Homo sapiens	0-4
21221443-2	2011	Cyt c was successfully immobilised using a thiol linker.	Sulfhydryl Compounds	43-48	cytochrome c, somatic	Homo sapiens	0-5
21291173-1	2011	[Ag(COD)(2)]PF(6) catalyzes the ring-opening of N-tosylaziridines and -azetidines with alcohols, amines, thiols, and related tethered 1,2-ethane dinucleophiles.	Sulfhydryl Compounds	105-111	small nuclear ribonucleoprotein polypeptides B and B1	Homo sapiens	4-7
21488133-4	2011	Using radiolabeled NaB((3) H)H(4) and Raney nickel as well as sulfhydryl assay (Ellman"s reagent), we confirmed that CDA could conjugate with cysteine through a thioether linkage.	Sulfhydryl Compounds	62-72	cytidine deaminase	Homo sapiens	117-120
20923387-4	2011	The resulting conjugates PAA-ATP1 and PAA-ATP2 displayed 168 +- 35 and 426 +- 55 mumol immobilized free thiol groups per gram polymer, respectively.	Sulfhydryl Compounds	104-109	ATP synthase F1 subunit alpha	Homo sapiens	29-33
21195754-13	2011	The striking difference between the effects on Trx2 and Trx1 implies a pronounced thiol redox stress that is largely directed at the mitochondria.	Sulfhydryl Compounds	82-87	thioredoxin 2	Homo sapiens	47-51
21195754-13	2011	The striking difference between the effects on Trx2 and Trx1 implies a pronounced thiol redox stress that is largely directed at the mitochondria.	Sulfhydryl Compounds	82-87	thioredoxin	Homo sapiens	56-60
21421124-0	2011	Probing the coordination behavior of Hg2+, CH3Hg+, and Cd2+ towards mixtures of two biological thiols by HPLC-ICP-AES.	Sulfhydryl Compounds	95-101	CD2 molecule	Homo sapiens	55-58
21148546-1	2011	Among all sulphhydryl oxidases involved in disulphide formation, quiescin-sulphhydryl oxidase (QSOX) is unique for its multidomain structure, protein thiol oxidation activity and highly efficient catalysis.	Sulfhydryl Compounds	150-155	quiescin sulfhydryl oxidase 1	Homo sapiens	65-93
21148546-1	2011	Among all sulphhydryl oxidases involved in disulphide formation, quiescin-sulphhydryl oxidase (QSOX) is unique for its multidomain structure, protein thiol oxidation activity and highly efficient catalysis.	Sulfhydryl Compounds	150-155	quiescin sulfhydryl oxidase 1	Homo sapiens	95-99
21148546-3	2011	Site-directed mutagenesis suggested that the C449-C452 motif was essential for the activity of human QSOX 1b; the C70-C73 motif was fundamental in electron transfer from thiol-containing substrate including reduced proteins, DTT, GSH rather than the phosphine-based thiol reductant TCEP, to the C449-C452 motif; and the C509-C512 motif was not involved in electron transfer during disulphide formation.	Sulfhydryl Compounds	170-175	quiescin sulfhydryl oxidase 1	Homo sapiens	101-105
21148546-3	2011	Site-directed mutagenesis suggested that the C449-C452 motif was essential for the activity of human QSOX 1b; the C70-C73 motif was fundamental in electron transfer from thiol-containing substrate including reduced proteins, DTT, GSH rather than the phosphine-based thiol reductant TCEP, to the C449-C452 motif; and the C509-C512 motif was not involved in electron transfer during disulphide formation.	Sulfhydryl Compounds	266-271	quiescin sulfhydryl oxidase 1	Homo sapiens	101-105
21183329-3	2011	After the complementary ss-DNA strand of anti-lysozyme aptamer was immobilized onto gold electrode via gold-thiol bond, the incubation with the aptamer resulted in the formation of ds-DNA.	Sulfhydryl Compounds	108-113	lysozyme	Homo sapiens	46-54
21097707-6	2011	Formation of etoposide radicals resulted in the oxidation of endogenous thiols, thus providing evidence for etoposide-mediated MPO-catalyzed redox cycling that may play a role in enhanced etoposide genotoxicity.	Sulfhydryl Compounds	72-78	myeloperoxidase	Homo sapiens	127-130
21229323-2	2011	Among the three Gpx isoforms, glutathione peroxidase 3 (Gpx3) is ubiquitously expressed and modulates the activities of redox-sensitive thiol proteins involved in various biological reactions.	Sulfhydryl Compounds	136-141	peroxiredoxin HYR1	Saccharomyces cerevisiae S288C	30-54
21229323-2	2011	Among the three Gpx isoforms, glutathione peroxidase 3 (Gpx3) is ubiquitously expressed and modulates the activities of redox-sensitive thiol proteins involved in various biological reactions.	Sulfhydryl Compounds	136-141	peroxiredoxin HYR1	Saccharomyces cerevisiae S288C	56-60
21051543-2	2011	Platyhelminth parasites have a unique and simplified thiol-based redox system, in which the selenoprotein thioredoxin-glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase domains, is the sole enzyme supplying electrons to oxidized glutathione (GSSG) and Trx.	Sulfhydryl Compounds	53-58	thioredoxin reductase 3	Homo sapiens	106-139
21051543-2	2011	Platyhelminth parasites have a unique and simplified thiol-based redox system, in which the selenoprotein thioredoxin-glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase domains, is the sole enzyme supplying electrons to oxidized glutathione (GSSG) and Trx.	Sulfhydryl Compounds	53-58	thioredoxin reductase 3	Homo sapiens	141-144
21051543-2	2011	Platyhelminth parasites have a unique and simplified thiol-based redox system, in which the selenoprotein thioredoxin-glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase domains, is the sole enzyme supplying electrons to oxidized glutathione (GSSG) and Trx.	Sulfhydryl Compounds	53-58	glutaredoxin	Homo sapiens	161-173
21051543-2	2011	Platyhelminth parasites have a unique and simplified thiol-based redox system, in which the selenoprotein thioredoxin-glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase domains, is the sole enzyme supplying electrons to oxidized glutathione (GSSG) and Trx.	Sulfhydryl Compounds	53-58	glutaredoxin	Homo sapiens	175-178
21051543-2	2011	Platyhelminth parasites have a unique and simplified thiol-based redox system, in which the selenoprotein thioredoxin-glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase domains, is the sole enzyme supplying electrons to oxidized glutathione (GSSG) and Trx.	Sulfhydryl Compounds	53-58	thioredoxin	Homo sapiens	106-117
21051543-2	2011	Platyhelminth parasites have a unique and simplified thiol-based redox system, in which the selenoprotein thioredoxin-glutathione reductase (TGR), a fusion of a glutaredoxin (Grx) domain to canonical thioredoxin reductase domains, is the sole enzyme supplying electrons to oxidized glutathione (GSSG) and Trx.	Sulfhydryl Compounds	53-58	thioredoxin	Homo sapiens	305-308
21123168-4	2011	By means of site-directed mutagenesis and by UV-visible and EPR spectroscopy, we also show that the ferric heme of reduced (dithiol) Rev-erbbeta can undergo a redox-triggered switch from imidazole/thiol ligation (via His-568 and Cys-384, based on a prior crystal structure) to His/neutral residue ligation upon oxidation to the disulfide form.	Sulfhydryl Compounds	126-131	nuclear receptor subfamily 1 group D member 2	Homo sapiens	133-144
21123168-0	2011	Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}.	Sulfhydryl Compounds	0-5	nuclear receptor subfamily 1 group D member 2	Homo sapiens	103-115
21164107-5	2011	15d-PGJ(2) inhibited sEH by specifically adducting to a highly conserved thiol (Cys521) adjacent to the catalytic center of the hydrolase.	Sulfhydryl Compounds	73-78	epoxide hydrolase 2, cytoplasmic	Mus musculus	21-24
21123168-2	2011	Here, we demonstrate that a thiol-disulfide redox switch controls the interaction between heme and the ligand-binding domain of Rev-erbbeta.	Sulfhydryl Compounds	28-33	nuclear receptor subfamily 1 group D member 2	Homo sapiens	128-139
20512387-6	2011	In addition, Trypanosomatids have a unique thiol-based metabolism, in which trypanothione (N1-N8-bis(glutathionyl)spermidine, T(SH)(2)) and trypanothione reductase (TR) replace many of the antioxidant and metabolic functions of the glutathione/glutathione reductase (GR) and thioredoxin/thioredoxin reductase (TrxR) systems present in the host.	Sulfhydryl Compounds	43-48	thioredoxin	Homo sapiens	275-286
20512387-6	2011	In addition, Trypanosomatids have a unique thiol-based metabolism, in which trypanothione (N1-N8-bis(glutathionyl)spermidine, T(SH)(2)) and trypanothione reductase (TR) replace many of the antioxidant and metabolic functions of the glutathione/glutathione reductase (GR) and thioredoxin/thioredoxin reductase (TrxR) systems present in the host.	Sulfhydryl Compounds	43-48	peroxiredoxin 5	Homo sapiens	287-308
20954832-9	2011	The findings reveal that MPO activity and its reactive products represent useful predictors of the doses of inhaled thiol antioxidants required to ameliorate airway oxidative stress and inflammation in CF patients and provide mechanistic insight into the antioxidative/anti-inflammatory mechanisms of action of GSH and NAC when administered into the CF lung.	Sulfhydryl Compounds	116-121	myeloperoxidase	Homo sapiens	25-28
21041070-4	2011	Exposure to bovine serum albumin (BSA) shows the self-limiting (d=1.2nm) [S(EO)(6)](2) SAMs to be the most highly protein resistant surfaces relative to bare Au and completely-formed SAMs of the two analogous thiols and octadecanethiol (ODT).	Sulfhydryl Compounds	209-215	methionine adenosyltransferase 1A	Homo sapiens	87-91
21117647-2	2011	Through a thiol-based mechanism, APE1 reduces a number of important transcription factors, including AP-1, p53, NF-kappaB, and HIF-1alpha.	Sulfhydryl Compounds	10-15	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	33-37
21039465-1	2011	Gamma interferon-inducible lysosomal thiol reductase (GILT) is an enzyme that catalyzes thiol bond reduction and plays an important role in the early steps of antigen processing.	Sulfhydryl Compounds	37-42	IFI30 lysosomal thiol reductase	Homo sapiens	54-58
21030559-5	2011	Thioredoxin-1 has an essential role in maintaining their surface thiol density as the first line of antioxidative defense mechanisms and is sensitive to proinflammatory stimuli, mainly tumor necrosis factor-alpha, in a nuclear factor-kappaB-dependent fashion.	Sulfhydryl Compounds	65-70	tumor necrosis factor	Homo sapiens	185-212
21283770-5	2011	Using cell-permeable, thiol-cleavable crosslinkers, normally labile interactions (i.e. p120 and E-cadherin) are stabilized in situ prior to isolation.	Sulfhydryl Compounds	22-27	catenin delta 1	Homo sapiens	87-91
21283770-5	2011	Using cell-permeable, thiol-cleavable crosslinkers, normally labile interactions (i.e. p120 and E-cadherin) are stabilized in situ prior to isolation.	Sulfhydryl Compounds	22-27	cadherin 1	Homo sapiens	96-106
21117647-2	2011	Through a thiol-based mechanism, APE1 reduces a number of important transcription factors, including AP-1, p53, NF-kappaB, and HIF-1alpha.	Sulfhydryl Compounds	10-15	tumor protein p53	Homo sapiens	107-110
21117647-2	2011	Through a thiol-based mechanism, APE1 reduces a number of important transcription factors, including AP-1, p53, NF-kappaB, and HIF-1alpha.	Sulfhydryl Compounds	10-15	nuclear factor kappa B subunit 1	Homo sapiens	112-121
21117647-2	2011	Through a thiol-based mechanism, APE1 reduces a number of important transcription factors, including AP-1, p53, NF-kappaB, and HIF-1alpha.	Sulfhydryl Compounds	10-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-137
22003457-0	2011	Tip-enhanced Raman spectroscopic imaging of patterned thiol monolayers.	Sulfhydryl Compounds	54-59	TOR signaling pathway regulator	Homo sapiens	0-3
21253614-13	2011	CONCLUSIONS/SIGNIFICANCE: We present evidence that NADPH oxidase derived ROS plays a role in the direct Treg mediated suppression of CD4+ effector T cells in a process that is blocked by thiol-containing antioxidants, NADPH oxidase inhibitors or a lack of Ncf1 expression in Tregs and Teffs.	Sulfhydryl Compounds	187-192	CD4 antigen	Mus musculus	133-136
21253614-13	2011	CONCLUSIONS/SIGNIFICANCE: We present evidence that NADPH oxidase derived ROS plays a role in the direct Treg mediated suppression of CD4+ effector T cells in a process that is blocked by thiol-containing antioxidants, NADPH oxidase inhibitors or a lack of Ncf1 expression in Tregs and Teffs.	Sulfhydryl Compounds	187-192	neutrophil cytosolic factor 1	Mus musculus	256-260
21817815-11	2011	Changes of myocardial redox state, predominantly GSH-dependent, appear to modulate MMP-2 and -9 activities by an inhibitory effect dependent on thiol content.	Sulfhydryl Compounds	144-149	matrix metallopeptidase 2	Homo sapiens	83-95
21415529-7	2011	These results indicate that reactivity (stability) of the thiol in MGST1 is affected by surrounding lipids, namely CL which prevents MGST1 activation by thiol modification.	Sulfhydryl Compounds	58-63	microsomal glutathione S-transferase 1	Homo sapiens	67-72
21415529-7	2011	These results indicate that reactivity (stability) of the thiol in MGST1 is affected by surrounding lipids, namely CL which prevents MGST1 activation by thiol modification.	Sulfhydryl Compounds	58-63	microsomal glutathione S-transferase 1	Homo sapiens	133-138
21415529-7	2011	These results indicate that reactivity (stability) of the thiol in MGST1 is affected by surrounding lipids, namely CL which prevents MGST1 activation by thiol modification.	Sulfhydryl Compounds	153-158	microsomal glutathione S-transferase 1	Homo sapiens	67-72
21415529-7	2011	These results indicate that reactivity (stability) of the thiol in MGST1 is affected by surrounding lipids, namely CL which prevents MGST1 activation by thiol modification.	Sulfhydryl Compounds	153-158	microsomal glutathione S-transferase 1	Homo sapiens	133-138
21415529-1	2011	Membrane-bound glutathione transferases (MGST1) distributed mostly in liver microsomal and mitochondrial membranes are activated by the thiol modification.	Sulfhydryl Compounds	136-141	microsomal glutathione S-transferase 1	Homo sapiens	41-46
21415529-4	2011	Although MGST1 was activated by the thiol alkylation with N-ethylmaleimide (NEM), the activation was suppressed in the presence of anionic phospholipids as clearly observed in the presence of CL.	Sulfhydryl Compounds	36-41	microsomal glutathione S-transferase 1	Homo sapiens	9-14
21091848-0	2011	Differential antiproliferation effect of 2"-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants.	Sulfhydryl Compounds	118-123	KRAS proto-oncogene, GTPase	Homo sapiens	72-77
21044882-9	2011	A similar reaction occurred with external thiols, such as DDT or cysteine, which also prevented PON1 inhibition and restored enzyme activity after inhibition.	Sulfhydryl Compounds	42-48	paraoxonase 1	Homo sapiens	96-100
20971184-0	2011	Yap1 activation by H2O2 or thiol-reactive chemicals elicits distinct adaptive gene responses.	Sulfhydryl Compounds	27-32	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	0-4
21044882-10	2011	Thus, the antiatherogenic properties of HDL could be, at least in part, related to the sulfhydryl-reducing characteristics of its associated PON1, which are further protected and recycled by the sulfhydryl amino acid cysteine.	Sulfhydryl Compounds	87-97	paraoxonase 1	Homo sapiens	141-145
20971184-3	2011	Thiol-reactive electrophiles can activate Yap1 directly by adduction to cysteine residues in the C-terminal domain containing Cys598, Cys620, and Cys629.	Sulfhydryl Compounds	0-5	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	42-46
20971184-4	2011	H(2)O(2) and N-ethylmaleimide (NEM) showed no cross-protection against each other, whereas another thiol-reactive chemical, acrolein, elicited Yap1-dependent cross-protection against NEM, but not H(2)O(2).	Sulfhydryl Compounds	99-104	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	143-147
21857084-0	2011	Prevention of the wortmannin-induced inhibition of phosphoinositide 3-kinase by sulfhydryl reducing agents.	Sulfhydryl Compounds	80-90	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	51-76
20971184-9	2011	These findings demonstrate that the distinct mechanisms of Yap1 activation by H(2)O(2) or thiol-reactive chemicals result in selective expression of protective genes.	Sulfhydryl Compounds	90-95	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	59-63
22112532-0	2011	Structural and functional features of Streptolysin O. Streptolysin O, a 63 kDa exotoxin coded by slo gene, is a well-characterised thiol-activated cytolysin, which damages cholesterol-containing membranes resulting in disruption and lysis of the target cell.	Sulfhydryl Compounds	131-136	perforin 1	Homo sapiens	147-156
22016646-6	2011	The absence of free thiol in the aged beer indicates that the thiol functional groups within the LTP1 protein were saturated and suggests that it is important in the flavour stability of beer by maintaining reduction capacity during the ageing process.	Sulfhydryl Compounds	62-67	non-specific lipid transport protein 1	Hordeum vulgare	97-101
21094256-8	2011	For molecules capable of direct or conjugate additions, the results suggest for the first time that TRPA1 may be activated preferentially by direct addition of the thiol group of TRPA1 cysteines to the agonist carbonyl carbon of alpha,beta-unsaturated carbonyl-containing compounds.	Sulfhydryl Compounds	164-169	transient receptor potential cation channel subfamily A member 1	Homo sapiens	100-105
21094256-8	2011	For molecules capable of direct or conjugate additions, the results suggest for the first time that TRPA1 may be activated preferentially by direct addition of the thiol group of TRPA1 cysteines to the agonist carbonyl carbon of alpha,beta-unsaturated carbonyl-containing compounds.	Sulfhydryl Compounds	164-169	transient receptor potential cation channel subfamily A member 1	Homo sapiens	179-184
21175893-9	2011	Over-expression of APS reductase had no effect on glucosinolate levels but did increase thiol levels, but neither glucosinolate nor thiol levels were affected in mutants lacking the APR2 isoform of this enzyme.	Sulfhydryl Compounds	88-93	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	19-32
20934533-6	2011	Additionally, it was found that thiol antioxidants inhibited the heme oxygenase-1 upregulation caused by cadmium and also by ethacrynic acid, which each decreased intracellular glutathione as did buthionine sulfoxamine.	Sulfhydryl Compounds	32-37	heme oxygenase 1	Homo sapiens	65-81
20934533-10	2011	It is concluded that adequate amounts of iron, which at the atomic level can serve as the pivotal element of heme in NADPH oxidase, must be present in cells to permit what appears to be thiol redox-sensitive, NADPH oxidase-dependent upregulation of heme oxygenase-1.	Sulfhydryl Compounds	186-191	heme oxygenase 1	Homo sapiens	249-265
22145046-8	2011	The data also suggest that thiol oxidation status of VEGFR-2 and c-Src correlates with their ability to physically interact with each other and c-Src activation.	Sulfhydryl Compounds	27-32	kinase insert domain receptor	Homo sapiens	53-60
22145046-5	2011	Co-immunoprecipitation studies using human coronary artery ECs (HCAEC) showed that VEGF-induced ROS-dependent interaction between VEGFR-2 and c-Src correlated with their thiol oxidation status.	Sulfhydryl Compounds	170-175	vascular endothelial growth factor A	Homo sapiens	83-87
22145046-8	2011	The data also suggest that thiol oxidation status of VEGFR-2 and c-Src correlates with their ability to physically interact with each other and c-Src activation.	Sulfhydryl Compounds	27-32	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-70
22145046-5	2011	Co-immunoprecipitation studies using human coronary artery ECs (HCAEC) showed that VEGF-induced ROS-dependent interaction between VEGFR-2 and c-Src correlated with their thiol oxidation status.	Sulfhydryl Compounds	170-175	kinase insert domain receptor	Homo sapiens	130-137
22145046-5	2011	Co-immunoprecipitation studies using human coronary artery ECs (HCAEC) showed that VEGF-induced ROS-dependent interaction between VEGFR-2 and c-Src correlated with their thiol oxidation status.	Sulfhydryl Compounds	170-175	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	142-147
22145046-8	2011	The data also suggest that thiol oxidation status of VEGFR-2 and c-Src correlates with their ability to physically interact with each other and c-Src activation.	Sulfhydryl Compounds	27-32	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	144-149
21603587-2	2011	Here, we report the mass spectrometric analysis of free thiols in RyR1 using the lipophilic, thiol-specific probe monobromobimane (MBB).	Sulfhydryl Compounds	56-62	ryanodine receptor 1	Homo sapiens	66-70
21603587-2	2011	Here, we report the mass spectrometric analysis of free thiols in RyR1 using the lipophilic, thiol-specific probe monobromobimane (MBB).	Sulfhydryl Compounds	56-61	ryanodine receptor 1	Homo sapiens	66-70
22346664-5	2011	Highly significant changes have been detected in the metabolism of thiol compounds-specifically the protein metallothionein (0.79-26.82 mmol/mg of protein), the enzyme glutathione S-transferase (190-5,827 mumol/min/mg of protein), and sulfhydryl groups (9.6-274.3 mumol cysteine/mg of protein).	Sulfhydryl Compounds	67-72	AT695_RS05355	Staphylococcus aureus	168-193
22125433-4	2011	The protein disulfide isomerase (PDI) family of redox chaperones is closely involved in both processes and is also implicated in protein unfolding and trafficking across the endoplasmic reticulum (ER) and towards the cytosol, a thiol-based redox locus for antigen processing.	Sulfhydryl Compounds	228-233	prolyl 4-hydroxylase subunit beta	Homo sapiens	4-31
22125433-4	2011	The protein disulfide isomerase (PDI) family of redox chaperones is closely involved in both processes and is also implicated in protein unfolding and trafficking across the endoplasmic reticulum (ER) and towards the cytosol, a thiol-based redox locus for antigen processing.	Sulfhydryl Compounds	228-233	prolyl 4-hydroxylase subunit beta	Homo sapiens	33-36
22346671-2	2011	Anti-human troponin T (anti-TnT) antibodies were covalently immobilized on the nanostructured electrode surface by thiol-aldehyde linkages.	Sulfhydryl Compounds	115-120	troponin T1, slow skeletal type	Homo sapiens	11-21
21179168-11	2010	In hypertensive vessels, eNOS S-glutathionylation is increased with impaired endothelium-dependent vasodilation that is restored by thiol-specific reducing agents, which reverse this S-glutathionylation.	Sulfhydryl Compounds	132-137	nitric oxide synthase 3	Homo sapiens	25-29
22346671-2	2011	Anti-human troponin T (anti-TnT) antibodies were covalently immobilized on the nanostructured electrode surface by thiol-aldehyde linkages.	Sulfhydryl Compounds	115-120	troponin T1, slow skeletal type	Homo sapiens	28-31
20831906-1	2010	The production of cGMP by the soluble form of guanylate cyclase (sGC) in bovine pulmonary arteries (BPA) is controlled by cytosolic NADPH maintaining reduced thiol and heme sites on sGC needed for activation by NO, and the levels of Nox oxidase-derived superoxide and peroxide that influence pathways regulating sGC activity.	Sulfhydryl Compounds	158-163	guanylate cyclase	Bos taurus	46-63
20837038-1	2011	Acyl-adenylates and acyl-CoA thioesters of bile acids (BAs) are reactive acyl-linked metabolites that have been shown to acylate the thiol group of glutathione (GSH); the reaction is catalyzed by glutathione S-transferase (GST) and the product is a thioester-linked BA-GSH conjugate.	Sulfhydryl Compounds	133-138	hematopoietic prostaglandin D synthase	Rattus norvegicus	196-221
20837038-1	2011	Acyl-adenylates and acyl-CoA thioesters of bile acids (BAs) are reactive acyl-linked metabolites that have been shown to acylate the thiol group of glutathione (GSH); the reaction is catalyzed by glutathione S-transferase (GST) and the product is a thioester-linked BA-GSH conjugate.	Sulfhydryl Compounds	133-138	hematopoietic prostaglandin D synthase	Rattus norvegicus	223-226
20869433-1	2010	Peroxiredoxins (Prxs) are a family of multifunctional antioxidant thiol-dependent peroxidases.	Sulfhydryl Compounds	66-71	peroxiredoxin 1	Mus musculus	0-14
20869434-5	2010	Flies underexpressing both dPrx3 and dPrx5 showed an 80% decrease in life span, a severe disruption in thiol homeostasis, and a massive induction of apoptosis in the muscle and digestive system tissues.	Sulfhydryl Compounds	103-108	Peroxiredoxin 3	Drosophila melanogaster	27-32
20869434-5	2010	Flies underexpressing both dPrx3 and dPrx5 showed an 80% decrease in life span, a severe disruption in thiol homeostasis, and a massive induction of apoptosis in the muscle and digestive system tissues.	Sulfhydryl Compounds	103-108	Peroxiredoxin 5	Drosophila melanogaster	37-42
20869434-7	2010	These results suggest that mitochondrial peroxiredoxins confer specific protection for thioredoxin/glutathione systems, play a critical role in the maintenance of global thiol homeostasis, and prevent the age-associated apoptosis and premature death.	Sulfhydryl Compounds	170-175	uncharacterized protein	Drosophila melanogaster	87-98
21043518-4	2010	TMC was covalently linked to a model antigen, ovalbumin (OVA), using thiol chemistry.	Sulfhydryl Compounds	69-74	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	46-55
21157000-5	2010	The bound  NO on the Cys189 thiol residue appears to impose a less efficient barrier to water permeation through AQP1 than the larger carboxyphenylmercuryl residue from p-chloromercuribenzoate.	Sulfhydryl Compounds	28-33	aquaporin 1 (Colton blood group)	Homo sapiens	113-117
20849982-3	2010	The midpoint potential (E(m)) of AtTDX was determined by redox titrations using the thiol-specific modifiers, monobromobimane (mBBr) and mal-PEG.	Sulfhydryl Compounds	84-89	tetraticopeptide domain-containing thioredoxin	Arabidopsis thaliana	33-38
20717703-4	2010	The Trx system is the major system responsible for maintaining the redox state of cells and this function involves thiol reduction mediated by selenol groups in TrxRs.	Sulfhydryl Compounds	115-120	thioredoxin 1	Mus musculus	4-7
21204767-3	2010	This study reports on the characterization in vitro of a fully phosphorothioated 20-mer oligonucleotide, complementary to p21 mRNA, radiolabeled with fluorine-18 using a thiol reactive prosthetic group.	Sulfhydryl Compounds	170-175	H3 histone pseudogene 16	Homo sapiens	122-125
20807524-9	2010	Decreased concentration of free thiol groups in sera suggest that free thiol group (Cys284) in PON1 might also be oxidized, which can affect PON1 activity.	Sulfhydryl Compounds	32-37	paraoxonase 1	Homo sapiens	95-99
20807524-9	2010	Decreased concentration of free thiol groups in sera suggest that free thiol group (Cys284) in PON1 might also be oxidized, which can affect PON1 activity.	Sulfhydryl Compounds	32-37	paraoxonase 1	Homo sapiens	141-145
20807524-9	2010	Decreased concentration of free thiol groups in sera suggest that free thiol group (Cys284) in PON1 might also be oxidized, which can affect PON1 activity.	Sulfhydryl Compounds	71-76	paraoxonase 1	Homo sapiens	95-99
20807524-9	2010	Decreased concentration of free thiol groups in sera suggest that free thiol group (Cys284) in PON1 might also be oxidized, which can affect PON1 activity.	Sulfhydryl Compounds	71-76	paraoxonase 1	Homo sapiens	141-145
20721684-2	2010	In this article, we show that Tat displays two alternative functional states depending on the presence of either one or three reduced sulphydryl groups in the cysteine-rich region, respectively.	Sulfhydryl Compounds	134-144	tyrosine aminotransferase	Homo sapiens	30-33
20946172-2	2010	This functional difference may be attributed to thiols exposed on the surface of plasma-type VWF multimers, but not on ULVWF multimers.	Sulfhydryl Compounds	48-54	von Willebrand factor	Homo sapiens	93-96
20946172-3	2010	Shear stress induces the exposed thiols to form disulfide bonds between laterally apposed plasma-type VWF multimers, leading to enhanced VWF binding to platelets.	Sulfhydryl Compounds	33-39	von Willebrand factor	Homo sapiens	102-105
20946172-3	2010	Shear stress induces the exposed thiols to form disulfide bonds between laterally apposed plasma-type VWF multimers, leading to enhanced VWF binding to platelets.	Sulfhydryl Compounds	33-39	von Willebrand factor	Homo sapiens	137-140
20946172-4	2010	OBJECTIVES: We tested a hypothesis that ADAMTS-13 has a disulfide bond reducing activity that regulates shear-induced thiol-disulfide exchange of VWF.	Sulfhydryl Compounds	118-123	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	40-49
20946172-4	2010	OBJECTIVES: We tested a hypothesis that ADAMTS-13 has a disulfide bond reducing activity that regulates shear-induced thiol-disulfide exchange of VWF.	Sulfhydryl Compounds	118-123	von Willebrand factor	Homo sapiens	146-149
20946172-6	2010	RESULTS: ADAMTS-13 contains a disulfide bond reducing activity that primarily targets disulfide bonds in plasma-type VWF multimers induced by high shear stress or formed with thiol beads, but not disulfide bonds in native multimeric structures.	Sulfhydryl Compounds	175-180	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	9-18
20946172-6	2010	RESULTS: ADAMTS-13 contains a disulfide bond reducing activity that primarily targets disulfide bonds in plasma-type VWF multimers induced by high shear stress or formed with thiol beads, but not disulfide bonds in native multimeric structures.	Sulfhydryl Compounds	175-180	von Willebrand factor	Homo sapiens	117-120
20946172-7	2010	Cysteine thiols targeted by this activity are in the VWF C-domain and are known to participate in shear-induced thiol-disulfide exchange.	Sulfhydryl Compounds	9-14	von Willebrand factor	Homo sapiens	53-56
20946172-9	2010	Blocking these active thiols eliminates this reducing activity and moderately decreases ADAMTS-13 activity in cleaving ULVWF strings anchored to endothelial cells under flow conditions, but not under static conditions.	Sulfhydryl Compounds	22-28	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	88-97
21139337-0	2010	Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone.	Sulfhydryl Compounds	24-30	GLI family zinc finger 2	Homo sapiens	88-93
21139337-2	2010	In our previous study, we found that a non-toxic dose of diphenylcyclopropene (DPCP), which is a potent skin sensitizer, induced an increase of cell-surface thiols in cells of a human monocytic cell line, THP-1.	Sulfhydryl Compounds	157-163	GLI family zinc finger 2	Homo sapiens	205-210
21139337-4	2010	First, we confirmed that DPCP induced an increase of cell-surface thiols not only in THP-1 cells, but also in primary monocytes.	Sulfhydryl Compounds	66-72	GLI family zinc finger 2	Homo sapiens	85-90
20924358-5	2010	Upon mild oxidative stress, SENP3 undergoes thiol modification, which recruits Hsp90.	Sulfhydryl Compounds	44-49	SUMO specific peptidase 3	Homo sapiens	28-33
20848033-7	2010	In addition, the introduction of a latent thiol group in the form of protected cysteamine at the C-terminus of the CD52 glycoforms will enable site-specific conjugation to a carrier protein to provide immunogens for generating CD52 glycoform-specific antibodies for functional studies.	Sulfhydryl Compounds	42-47	CD52 molecule	Homo sapiens	115-119
20848033-7	2010	In addition, the introduction of a latent thiol group in the form of protected cysteamine at the C-terminus of the CD52 glycoforms will enable site-specific conjugation to a carrier protein to provide immunogens for generating CD52 glycoform-specific antibodies for functional studies.	Sulfhydryl Compounds	42-47	CD52 molecule	Homo sapiens	227-231
20924358-5	2010	Upon mild oxidative stress, SENP3 undergoes thiol modification, which recruits Hsp90.	Sulfhydryl Compounds	44-49	heat shock protein 90 alpha family class A member 1	Homo sapiens	79-84
20840855-5	2010	We show that the loss of CYP2A5 expression did not alter systemic clearance of DCBN (at 25 mg/kg); but it did inhibit DCBN-induced non-protein thiol depletion and cytotoxicity in the OM.	Sulfhydryl Compounds	143-148	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	25-31
20949898-2	2010	The assay is based on a disulfide-thiol interchange reaction between the intramolecularly quenched dimeric dye BODIPY FL l-cystine and thiocholine generated by the AChE-catalyzed hydrolysis of acetylthiocholine (ATCh), which results in a brightly fluorescent monomeric product owing to the cleavage of the disulfide-coupled form of the dye.	Sulfhydryl Compounds	34-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
20829229-5	2010	We have exploited the ability of glutaredoxins (Grxs) to reduce mixed disulfides to protein thiols either in the cytoplasm and in the IMS (Grx1) or in the mitochondrial matrix (Grx2) as a tool for restoring a correct redox environment and preventing the aggregation of mutant SOD1.	Sulfhydryl Compounds	92-98	glutaredoxin	Homo sapiens	139-143
20927107-5	2010	Here we show that the reduced unbridged form of angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized sulphydryl-bridged form, which preferentially interacts with receptor-bound renin.	Sulfhydryl Compounds	134-144	angiotensinogen	Homo sapiens	48-63
20875491-3	2010	In vitro, 2h-incubation with both molecules was found to increase intra-macrophage thiol content; in vivo, Ova-sensitized mice pre-treated by intraperitoneal administration of the pro-GSH molecules showed an increase in plasma anti-Ova IgG2a and IgG2b, characterizing Th1 immune response, and a decrease in IgG1, typical of the Th2 response.	Sulfhydryl Compounds	83-88	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	107-110
20875491-5	2010	Although immune responses are in vivo mediated both by dendritic cells and macrophages, the data reported in this paper corroborate the suggestion that the pro-GSH molecules, increasing the intra-cellular thiol pool, modulate the Th1/Th2 balance favouring Th1-type responses and may be employed as Th1-directing adjuvants in new vaccination protocols and as immunomodulators in those diseases where Th1 response patterns are compromised in favour of Th2.	Sulfhydryl Compounds	205-210	negative elongation factor complex member C/D, Th1l	Mus musculus	230-233
20875491-0	2010	The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice.	Sulfhydryl Compounds	33-39	negative elongation factor complex member C/D, Th1l	Mus musculus	85-88
20875491-0	2010	The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice.	Sulfhydryl Compounds	33-39	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	100-109
20927107-5	2010	Here we show that the reduced unbridged form of angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized sulphydryl-bridged form, which preferentially interacts with receptor-bound renin.	Sulfhydryl Compounds	134-144	renin	Homo sapiens	210-215
20927107-7	2010	Specifically, we demonstrate the oxidative switch of angiotensinogen to its more active sulphydryl-bridged form in the maternal circulation in pre-eclampsia-the hypertensive crisis of pregnancy that threatens the health and survival of both mother and child.	Sulfhydryl Compounds	88-98	angiotensinogen	Homo sapiens	53-68
20937692-9	2010	However, although the inner part of the pore is lined by amino-terminal amino acids in connexin channels, thiol modification was detected in carboxyterminal amino acids in Panx1 channels by SCAM analysis.	Sulfhydryl Compounds	106-111	pannexin 1	Homo sapiens	172-177
20446771-8	2010	The same effect was achieved by the nontargeted antioxidant Trolox at higher concentration, but the thiol antioxidant N-acetylcysteine (NAC) inhibited MMP activity and was not able to induce myofibroblast differentiation.	Sulfhydryl Compounds	100-105	matrix metallopeptidase 9	Homo sapiens	151-154
20684984-4	2010	Upon exposure to ultra-violet excitation, the coumarin groups were cleaved leaving reactive thiols to couple with maleimide-activated VEGFA.	Sulfhydryl Compounds	92-98	vascular endothelial growth factor A	Mus musculus	134-139
20692357-9	2010	Cell treatment with PDTC increased significantly the level of Hsp90alpha thiol oxidation, a posttranslational modification known to inhibit its chaperone function.	Sulfhydryl Compounds	73-78	heat shock protein 90 alpha family class A member 1	Homo sapiens	62-72
20702080-2	2010	Recombinant pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase (GDH) is covalently coupled to a PQQ-layer which is adsorbed onto thiol-modified MWCNTs at a gold electrode.	Sulfhydryl Compounds	141-146	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	53-74
20619250-11	2010	Since PTZ give rise to cation radicals chemically by the action of peroxidases and cyanide inhibited the PTZ-induced swelling, we propose that PTZ bury in the inner mitochondrial membrane and the chemically generated PTZ cation radicals modify specific thiol groups that in the presence of Ca(2+) result in MPT associated to cytochrome c release.	Sulfhydryl Compounds	253-258	cytochrome c, somatic	Homo sapiens	325-337
20702080-2	2010	Recombinant pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase (GDH) is covalently coupled to a PQQ-layer which is adsorbed onto thiol-modified MWCNTs at a gold electrode.	Sulfhydryl Compounds	141-146	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	76-79
20731670-2	2010	The compounds 2-4 were performed by the reaction of thiols and 2-chloro-N-substituted-acetamides and active in the lower micromolar concentration (1.25-20.83 muM).	Sulfhydryl Compounds	52-58	latexin	Homo sapiens	158-161
20569240-2	2010	In this study, we investigated the role of thiol redox status in the modulation of the N-methyl-d-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP) in CA1 areas of hippocampal slices.	Sulfhydryl Compounds	43-48	carbonic anhydrase 1	Homo sapiens	167-170
20664003-4	2010	To test this hypothesis we have begun to obtain structural information about family B GPCRs, using as a prototype the CRF(1), by determining the ability of sulfhydryl-specific methanethiosulfonate derivatives, such as the methanethiosulfonate-ethylammonium (MTSEA), to react with CRF(1) and thus irreversibly inhibit (125)I-Tyr(0)-sauvagine binding.	Sulfhydryl Compounds	156-166	corticotropin releasing hormone receptor 1	Homo sapiens	118-124
20664003-4	2010	To test this hypothesis we have begun to obtain structural information about family B GPCRs, using as a prototype the CRF(1), by determining the ability of sulfhydryl-specific methanethiosulfonate derivatives, such as the methanethiosulfonate-ethylammonium (MTSEA), to react with CRF(1) and thus irreversibly inhibit (125)I-Tyr(0)-sauvagine binding.	Sulfhydryl Compounds	156-166	corticotropin releasing hormone receptor 1	Homo sapiens	280-286
20631055-8	2010	It is noteworthy that 15d-PGJ(2) elicited GSTP1-1 cross-linking in vitro, a process that could be mimicked by other dienone cyclopentenone PG, such as Delta(12)-PGJ(2), and by the bifunctional thiol reagent dibromobimane, suggesting that cyclopentenone PG may be directly involved in oligomer formation.	Sulfhydryl Compounds	193-198	glutathione S-transferase pi 1	Homo sapiens	42-49
20669236-2	2010	Ero1p contains a pair of essential disulfide bonds that participate directly in the electron transfer pathway from substrate thiol groups to oxygen.	Sulfhydryl Compounds	125-130	ER oxidoreductin	Saccharomyces cerevisiae S288C	0-5
20669236-4	2010	In particular, the C150A/C295A Ero1p mutant exhibits increased thiol oxidation in vitro and in vivo and interferes with redox homeostasis in yeast cells by hyperoxidizing the ER.	Sulfhydryl Compounds	63-68	ER oxidoreductin	Saccharomyces cerevisiae S288C	31-36
20678484-5	2010	Prevention of 15d-PGJ2 induced mitochondrial elongation by thiol antioxidants prevented not only loss of OPA1 isoforms but also its ubiquitination.	Sulfhydryl Compounds	59-64	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	105-109
20457661-4	2010	To test this hypothesis, we first examined whether the RNA-cleaving enzyme polynucleotide phosphorylase (PNPase), which can split poly-adenylate (poly-A) by arsenolysis into units of AMP-AsV (a homologue of ADP-AsV), could also promote reduction of AsV to AsIII in presence of thiols.	Sulfhydryl Compounds	277-283	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	75-103
20457661-4	2010	To test this hypothesis, we first examined whether the RNA-cleaving enzyme polynucleotide phosphorylase (PNPase), which can split poly-adenylate (poly-A) by arsenolysis into units of AMP-AsV (a homologue of ADP-AsV), could also promote reduction of AsV to AsIII in presence of thiols.	Sulfhydryl Compounds	277-283	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	105-111
20457661-6	2010	PNPase-mediated AsV reduction depended on arsenolysis of poly-A and presence of a thiol.	Sulfhydryl Compounds	82-87	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	0-6
20457661-9	2010	Although various thiols did not influence the arsenolytic yield of AMP-AsV, they differentially promoted the PNPase-mediated reduction of AsV, with GSH being the most effective.	Sulfhydryl Compounds	17-23	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	109-115
20551379-3	2010	Our group has shown that thioredoxin 1 (TRX-1) generates free thiols in beta2GPI, a process that may have a regulatory role in platelet adhesion.	Sulfhydryl Compounds	62-68	thioredoxin	Homo sapiens	25-38
20551379-3	2010	Our group has shown that thioredoxin 1 (TRX-1) generates free thiols in beta2GPI, a process that may have a regulatory role in platelet adhesion.	Sulfhydryl Compounds	62-68	thioredoxin	Homo sapiens	40-45
20551379-3	2010	Our group has shown that thioredoxin 1 (TRX-1) generates free thiols in beta2GPI, a process that may have a regulatory role in platelet adhesion.	Sulfhydryl Compounds	62-68	apolipoprotein H	Homo sapiens	72-80
20551379-4	2010	This report extends these studies and shows for the first time evidence of beta2GPI with free thiols in vivo in both multiple human and murine serum samples.	Sulfhydryl Compounds	94-100	apolipoprotein H	Homo sapiens	75-83
20551379-5	2010	To explore how the vascular surface may modulate the redox status of beta2GPI, unstimulated human endothelial cells and EAhy926 cells are shown to be capable of amplifying the effect of free thiol generation within beta2GPI.	Sulfhydryl Compounds	191-196	apolipoprotein H	Homo sapiens	69-77
20551379-5	2010	To explore how the vascular surface may modulate the redox status of beta2GPI, unstimulated human endothelial cells and EAhy926 cells are shown to be capable of amplifying the effect of free thiol generation within beta2GPI.	Sulfhydryl Compounds	191-196	apolipoprotein H	Homo sapiens	215-223
20551379-7	2010	Furthermore, one or more of these generated free thiols within beta2GPI are also shown to be nitrosylated.	Sulfhydryl Compounds	49-55	apolipoprotein H	Homo sapiens	63-71
20551379-8	2010	Finally, the functional significance of these findings is explored, by showing that free thiol-containing beta2GPI has a powerful effect in protecting endothelial cells and EAhy926 cells from oxidative stress-induced cell death.	Sulfhydryl Compounds	89-94	apolipoprotein H	Homo sapiens	106-114
20715271-0	2010	Metallization of ultra-thin, non-thiol SAMs with flat-lying molecular units: Pd on 1, 4-dicyanobenzene.	Sulfhydryl Compounds	33-38	methionine adenosyltransferase 1A	Homo sapiens	39-43
20385619-4	2010	CSE and aldehydes dose and time dependently decreased SIRT1 protein levels, with EC(50) of 1% for CSE and 30 microM for acrolein at 6 h, and &gt;80% inhibition at 24 h with CSE, which was regulated by modulation of intracellular thiol status of the cells.	Sulfhydryl Compounds	229-234	sirtuin 1	Mus musculus	54-59
20558128-12	2010	The thiol reducing agents, dithiothreitol (100 microM) or beta-mercaptoethanol (1.4 microM), attenuated piceatannol-induced Nrf2 activation and HO-1 expression.	Sulfhydryl Compounds	4-9	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
20558128-12	2010	The thiol reducing agents, dithiothreitol (100 microM) or beta-mercaptoethanol (1.4 microM), attenuated piceatannol-induced Nrf2 activation and HO-1 expression.	Sulfhydryl Compounds	4-9	heme oxygenase 1	Homo sapiens	144-148
20536427-1	2010	The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation.	Sulfhydryl Compounds	123-128	thioredoxin	Homo sapiens	14-17
20536427-1	2010	The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation.	Sulfhydryl Compounds	123-128	thioredoxin	Homo sapiens	19-30
20536427-1	2010	The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation.	Sulfhydryl Compounds	123-128	thioredoxin	Homo sapiens	56-59
20536427-1	2010	The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation.	Sulfhydryl Compounds	123-128	thioredoxin	Homo sapiens	56-59
20536427-1	2010	The classical Trx (thioredoxin) system, composed of TR (Trx reductase), Trx and NADPH, defines a major pathway of cellular thiol-based redox regulation.	Sulfhydryl Compounds	123-128	2,4-dienoyl-CoA reductase 1	Homo sapiens	80-85
20675098-4	2010	Physiologically, serum albumin exists in a reduced form with a free thiol contributing to its antioxidant properties.	Sulfhydryl Compounds	68-73	albumin	Homo sapiens	23-30
20435158-9	2010	The induction of IDO by IFN-gamma in HLE-B3 cells caused increases in intracellular ROS, cytosolic cytochrome c and caspase-3 activity, along with a decrease in protein-free thiol content.	Sulfhydryl Compounds	174-179	indoleamine 2,3-dioxygenase 1	Homo sapiens	17-20
20435158-9	2010	The induction of IDO by IFN-gamma in HLE-B3 cells caused increases in intracellular ROS, cytosolic cytochrome c and caspase-3 activity, along with a decrease in protein-free thiol content.	Sulfhydryl Compounds	174-179	interferon gamma	Homo sapiens	24-33
20650613-0	2010	A prospective analysis of anti-desmoglein antibody profiles in patients with rheumatoid arthritis treated with thiol compounds.	Sulfhydryl Compounds	111-116	desmoglein 1	Homo sapiens	26-41
20665692-2	2010	The technology involves formation of free, reactive thiol groups upon UV excitation of protein aromatic residues located in spatial proximity of disulphide bridges, a conserved structural feature in both PSA and Fab molecules.	Sulfhydryl Compounds	52-57	kallikrein related peptidase 3	Homo sapiens	204-207
20665692-2	2010	The technology involves formation of free, reactive thiol groups upon UV excitation of protein aromatic residues located in spatial proximity of disulphide bridges, a conserved structural feature in both PSA and Fab molecules.	Sulfhydryl Compounds	52-57	FA complementation group B	Homo sapiens	212-215
20650613-2	2010	OBJECTIVES: To understand the serial alteration of anti-desmoglein (Dsg) antibody profile in patients with rheumatoid arthritis (RA) receiving thiol compounds.	Sulfhydryl Compounds	143-148	desmoglein 1	Homo sapiens	51-66
20650613-2	2010	OBJECTIVES: To understand the serial alteration of anti-desmoglein (Dsg) antibody profile in patients with rheumatoid arthritis (RA) receiving thiol compounds.	Sulfhydryl Compounds	143-148	desmoglein 1	Homo sapiens	68-71
20650613-10	2010	CONCLUSION: RA patients receiving any of the thiol compounds may gain autoantibodies to non-conformational epitopes of either Dsg1 or Dsg3, and that such autoantibodies alone are not capable of inducing acantholysis.	Sulfhydryl Compounds	45-50	desmoglein 1	Homo sapiens	126-130
20650613-10	2010	CONCLUSION: RA patients receiving any of the thiol compounds may gain autoantibodies to non-conformational epitopes of either Dsg1 or Dsg3, and that such autoantibodies alone are not capable of inducing acantholysis.	Sulfhydryl Compounds	45-50	desmoglein 3	Homo sapiens	134-138
20799947-0	2010	Hypertonic saline increases lung epithelial lining fluid glutathione and thiocyanate: two protective CFTR-dependent thiols against oxidative injury.	Sulfhydryl Compounds	116-122	cystic fibrosis transmembrane conductance regulator	Mus musculus	101-105
20677743-2	2010	Here, protein disulfide isomerase (PDI) and dual specificity phosphatase 12 (DUSP12 or hYVH1) were S-nitrosylated or S-glutathionylated, their free thiols differentially alkylated, and subjected to proteolysis.	Sulfhydryl Compounds	148-154	prolyl 4-hydroxylase subunit beta	Homo sapiens	6-33
20677743-2	2010	Here, protein disulfide isomerase (PDI) and dual specificity phosphatase 12 (DUSP12 or hYVH1) were S-nitrosylated or S-glutathionylated, their free thiols differentially alkylated, and subjected to proteolysis.	Sulfhydryl Compounds	148-154	prolyl 4-hydroxylase subunit beta	Homo sapiens	35-38
20677743-2	2010	Here, protein disulfide isomerase (PDI) and dual specificity phosphatase 12 (DUSP12 or hYVH1) were S-nitrosylated or S-glutathionylated, their free thiols differentially alkylated, and subjected to proteolysis.	Sulfhydryl Compounds	148-154	dual specificity phosphatase 12	Homo sapiens	44-75
20677743-2	2010	Here, protein disulfide isomerase (PDI) and dual specificity phosphatase 12 (DUSP12 or hYVH1) were S-nitrosylated or S-glutathionylated, their free thiols differentially alkylated, and subjected to proteolysis.	Sulfhydryl Compounds	148-154	dual specificity phosphatase 12	Homo sapiens	77-83
20677743-2	2010	Here, protein disulfide isomerase (PDI) and dual specificity phosphatase 12 (DUSP12 or hYVH1) were S-nitrosylated or S-glutathionylated, their free thiols differentially alkylated, and subjected to proteolysis.	Sulfhydryl Compounds	148-154	dual specificity phosphatase 12	Homo sapiens	87-92
20210649-3	2010	These processes depend on the common thiol reductants, glutathione (GSH) and thioredoxin-1 (Trx1).	Sulfhydryl Compounds	37-42	thioredoxin	Homo sapiens	77-90
20538586-0	2010	Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids.	Sulfhydryl Compounds	135-141	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	37-53
20538586-0	2010	Postischemic deactivation of cardiac aldose reductase: role of glutathione S-transferase P and glutaredoxin in regeneration of reduced thiols from sulfenic acids.	Sulfhydryl Compounds	135-141	glutaredoxin	Mus musculus	95-107
20210649-3	2010	These processes depend on the common thiol reductants, glutathione (GSH) and thioredoxin-1 (Trx1).	Sulfhydryl Compounds	37-42	thioredoxin	Homo sapiens	92-96
20494366-6	2010	The resistance of the MSI-Au composites increased during the thiol step, while it decreased by hybridizing, due to the conductance difference between single- and double-stranded DNA chains.	Sulfhydryl Compounds	61-66	RB binding protein 4, chromatin remodeling factor	Homo sapiens	22-25
20538591-4	2010	According to structural models of the gp120-CD4 receptor complex, substitution of Ser(60) on the CD4 domain 1 alpha-helix with Cys positions a thiol in proximity of the gp120 V1/V2 loop disulfide (Cys(126)-Cys(196)), satisfying the stereochemical and geometric conditions for redox exchange between CD4 Cys(60) and gp120 Cys(126), and the consequent formation of an interchain disulfide bond.	Sulfhydryl Compounds	143-148	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	38-43
20655236-1	2010	Dithiolethiones upregulate the expression of cancer-preventive proteins via modification of thiol residues in the Keap1-Nrf2 transcription factor complex.	Sulfhydryl Compounds	2-7	kelch like ECH associated protein 1	Homo sapiens	114-119
20655236-1	2010	Dithiolethiones upregulate the expression of cancer-preventive proteins via modification of thiol residues in the Keap1-Nrf2 transcription factor complex.	Sulfhydryl Compounds	2-7	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
20538591-4	2010	According to structural models of the gp120-CD4 receptor complex, substitution of Ser(60) on the CD4 domain 1 alpha-helix with Cys positions a thiol in proximity of the gp120 V1/V2 loop disulfide (Cys(126)-Cys(196)), satisfying the stereochemical and geometric conditions for redox exchange between CD4 Cys(60) and gp120 Cys(126), and the consequent formation of an interchain disulfide bond.	Sulfhydryl Compounds	143-148	CD4 molecule	Homo sapiens	44-47
20538591-4	2010	According to structural models of the gp120-CD4 receptor complex, substitution of Ser(60) on the CD4 domain 1 alpha-helix with Cys positions a thiol in proximity of the gp120 V1/V2 loop disulfide (Cys(126)-Cys(196)), satisfying the stereochemical and geometric conditions for redox exchange between CD4 Cys(60) and gp120 Cys(126), and the consequent formation of an interchain disulfide bond.	Sulfhydryl Compounds	143-148	CD4 molecule	Homo sapiens	97-100
20538591-4	2010	According to structural models of the gp120-CD4 receptor complex, substitution of Ser(60) on the CD4 domain 1 alpha-helix with Cys positions a thiol in proximity of the gp120 V1/V2 loop disulfide (Cys(126)-Cys(196)), satisfying the stereochemical and geometric conditions for redox exchange between CD4 Cys(60) and gp120 Cys(126), and the consequent formation of an interchain disulfide bond.	Sulfhydryl Compounds	143-148	CD4 molecule	Homo sapiens	97-100
20530483-9	2010	We conclude the following: a) that large conformational changes induced by Ca(2+) can be detected in IP(3)Rs in situ; b) these changes may be driven by Ca(2+) binding to the N-terminal suppressor domain and expose a group of closely spaced endogenous thiols in the channel domain; and c) that the C-terminal cytosol-exposed tail of the IP(3)R may be relatively inaccessible to regulatory proteins unless Ca(2+) is present.	Sulfhydryl Compounds	251-257	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	101-107
21073418-3	2010	However, the functional state of fibrillarin with reduced or oxidized thiol groups is still practically unstudied.	Sulfhydryl Compounds	70-75	fibrillarin	Homo sapiens	33-44
20624390-2	2010	The thioredoxin (TRX) system, a major thiol antioxidant system, regulates the reduction of intracellular ROS.	Sulfhydryl Compounds	38-43	thioredoxin 1	Mus musculus	4-15
20624390-2	2010	The thioredoxin (TRX) system, a major thiol antioxidant system, regulates the reduction of intracellular ROS.	Sulfhydryl Compounds	38-43	thioredoxin 1	Mus musculus	17-20
20979592-4	2010	METHODS:  beta(2) GPI, reduced by thioredoxin-1, was labeled with the selective sulfhydryl probe N(a)-(3-maleimidylpropionyl)biocytin and subjected to mass spectrometry to identify the specific cysteines involved in the thiol exchange reaction.	Sulfhydryl Compounds	220-225	apolipoprotein H	Homo sapiens	10-21
20417075-4	2010	It was noted that the surface hydrophilicity of -SO(3)H/-CH(3) mixed SAMs was increased with the solution mole fraction of -SO(3)H terminated thiol.	Sulfhydryl Compounds	142-147	methionine adenosyltransferase 1A	Homo sapiens	69-73
20979592-10	2010	CONCLUSIONS: Given the importance of thiol oxidoreductases in thrombus formation, we provide preliminary evidence that the thiol-dependent interaction of beta(2) GPI with VWF may contribute to the redox regulation of platelet adhesion.	Sulfhydryl Compounds	37-42	apolipoprotein H	Homo sapiens	154-165
20979592-10	2010	CONCLUSIONS: Given the importance of thiol oxidoreductases in thrombus formation, we provide preliminary evidence that the thiol-dependent interaction of beta(2) GPI with VWF may contribute to the redox regulation of platelet adhesion.	Sulfhydryl Compounds	37-42	von Willebrand factor	Homo sapiens	171-174
20572017-0	2010	Probing local structural fluctuations in myoglobin by size-dependent thiol-disulfide exchange.	Sulfhydryl Compounds	69-74	myoglobin	Homo sapiens	41-50
20473443-1	2010	Thiol-disulfide exchange reactions between thiol-disulfide oxidoreductases (e.g. thioredoxin or Trx) and client proteins can obtain a rate several orders faster than those between chemical reagents (e.g. dithiothreitol) and client proteins.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	81-92
20473443-1	2010	Thiol-disulfide exchange reactions between thiol-disulfide oxidoreductases (e.g. thioredoxin or Trx) and client proteins can obtain a rate several orders faster than those between chemical reagents (e.g. dithiothreitol) and client proteins.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	96-99
20557125-3	2010	As corroborated by electrophoresis analysis, both beta-lactoglobulin (beta-lg) and alpha-lactalbumin (alpha-la) were involved in the formation of aggregates via the thiol-disulfide interchange reaction and/or noncovalent interactions.	Sulfhydryl Compounds	165-170	lactalbumin alpha	Homo sapiens	83-100
20550197-1	2010	O-Acetylserine sulfhydrylase is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the final step in the cysteine biosynthetic pathway in enteric bacteria and plants, the replacement of the beta-acetoxy group of O-acetyl-L-serine (OAS) by a thiol to give L-cysteine.	Sulfhydryl Compounds	253-258	pyridoxal phosphatase	Homo sapiens	58-61
20501650-13	2010	These data indicate that H(2)O(2) activates TRPC6 channels via modification of thiol groups of intracellular proteins.	Sulfhydryl Compounds	79-84	transient receptor potential cation channel subfamily C member 6	Homo sapiens	44-49
20557125-5	2010	In comparison with the control bar without Cys, the thiol-disulfide interchange reaction was significantly reduced by Cys (WPI/Cys = 0.05), increased by Cys (WPI/Cys = 0.25), and inhibited by NEM (WPI/NEM = 2).	Sulfhydryl Compounds	52-57	actin alpha 1, skeletal muscle	Homo sapiens	201-208
20388560-7	2010	In conclusion, this study showed that the formation of S-sulfonation of TTR through oxidative modifications of the thiol residue on the 10th cysteine of TTR is an important trigger step in the formation of transthyretin-related amyloid fibril.	Sulfhydryl Compounds	115-120	transthyretin	Homo sapiens	206-219
20703376-2	2010	SAMs can be readily formed from thiols prepared by in situ deprotection of the thioacetates in the presence of a gold-coated silicon wafer.	Sulfhydryl Compounds	32-38	methionine adenosyltransferase 1A	Homo sapiens	0-4
20388560-7	2010	In conclusion, this study showed that the formation of S-sulfonation of TTR through oxidative modifications of the thiol residue on the 10th cysteine of TTR is an important trigger step in the formation of transthyretin-related amyloid fibril.	Sulfhydryl Compounds	115-120	transthyretin	Homo sapiens	72-75
20536126-0	2010	STM tip catalyzed adsorption of thiol molecules at the nanometer scale.	Sulfhydryl Compounds	32-37	sulfotransferase family 1A member 3	Homo sapiens	0-3
20536126-0	2010	STM tip catalyzed adsorption of thiol molecules at the nanometer scale.	Sulfhydryl Compounds	32-37	TOR signaling pathway regulator	Homo sapiens	4-7
20536126-3	2010	We have found that the thiol headgroup is the critical functional group for this catalysis and the catalytic material is the tungsten oxide layer of the tip.	Sulfhydryl Compounds	23-28	TOR signaling pathway regulator	Homo sapiens	153-156
20388560-7	2010	In conclusion, this study showed that the formation of S-sulfonation of TTR through oxidative modifications of the thiol residue on the 10th cysteine of TTR is an important trigger step in the formation of transthyretin-related amyloid fibril.	Sulfhydryl Compounds	115-120	transthyretin	Homo sapiens	153-156
20488891-1	2010	Glutathione is a major cellular thiol that is maintained in the reduced state by glutathione reductase (GR), which is encoded by two genes in Arabidopsis (Arabidopsis thaliana; GR1 and GR2).	Sulfhydryl Compounds	32-37	glutathione reductase	Arabidopsis thaliana	81-102
20473684-4	2010	While in Arabidopsis the key enzyme of sulfate assimilation, adenosine 5"-phosphosulfate reductase (APR), is feedback repressed by thiols and induced by reduced levels of glutathione, in P. patens such regulation does not occur.	Sulfhydryl Compounds	131-137	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	61-98
20473684-4	2010	While in Arabidopsis the key enzyme of sulfate assimilation, adenosine 5"-phosphosulfate reductase (APR), is feedback repressed by thiols and induced by reduced levels of glutathione, in P. patens such regulation does not occur.	Sulfhydryl Compounds	131-137	5'adenylylphosphosulfate reductase 2	Arabidopsis thaliana	100-103
20488891-1	2010	Glutathione is a major cellular thiol that is maintained in the reduced state by glutathione reductase (GR), which is encoded by two genes in Arabidopsis (Arabidopsis thaliana; GR1 and GR2).	Sulfhydryl Compounds	32-37	glutathione reductase	Arabidopsis thaliana	104-106
20488891-1	2010	Glutathione is a major cellular thiol that is maintained in the reduced state by glutathione reductase (GR), which is encoded by two genes in Arabidopsis (Arabidopsis thaliana; GR1 and GR2).	Sulfhydryl Compounds	32-37	glutathione-disulfide reductase	Arabidopsis thaliana	177-180
20488891-1	2010	Glutathione is a major cellular thiol that is maintained in the reduced state by glutathione reductase (GR), which is encoded by two genes in Arabidopsis (Arabidopsis thaliana; GR1 and GR2).	Sulfhydryl Compounds	32-37	glyoxylate reductase 2	Arabidopsis thaliana	185-188
20457211-10	2010	Thimerosal and EtHgCl also induced a calcium (Ca2+) influx with a peak at 3h, suggesting that Ca2+ influx is a secondary event following ROS induction as Ca2+ influx was suppressed after pretreatment with NAC but not with thiol-independent antioxidants.	Sulfhydryl Compounds	222-227	X-linked Kx blood group	Homo sapiens	205-208
20417223-8	2010	The role of thiol oxidation in the initiation of mono-DC activation was confirmed by a pre-treatment with N-acetyl-l-cysteine which strongly decreased chemical-induced CD86 overexpression.	Sulfhydryl Compounds	12-17	CD86 molecule	Homo sapiens	168-172
20348090-8	2010	Thus, the amino-terminal domain of yeast Pdi1p is on a preferred pathway for oxidizing the ER thiol pool.	Sulfhydryl Compounds	94-99	protein disulfide isomerase PDI1	Saccharomyces cerevisiae S288C	41-46
20345183-6	2010	The reaction of TrxR with iodoacetamide, which selectively modifies free thiol or selenol on proteins, was also markedly reduced by CEES, suggesting that CEES induces covalent modification of the reduced selenocysteine-containing active site in the enzyme.	Sulfhydryl Compounds	73-78	peroxiredoxin 5	Homo sapiens	16-20
20981235-1	2010	Glutathione transferase enzymes (GSTs) catalyze reactions in which electrophiles are conjugated to the tripeptide thiol glutathione.	Sulfhydryl Compounds	114-119	hematopoietic prostaglandin D synthase	Homo sapiens	33-37
20364116-6	2010	Furthermore, treatment with the thiol antioxidant, N-acetyl cysteine or with polyethylene glycol-conjugated superoxide dismutase and catalase, protected neuroblastoma cells from 2DG-induced cell killing.	Sulfhydryl Compounds	32-37	catalase	Homo sapiens	133-141
24281108-5	2010	However, from the absorbance at 325 nm, it was found that the GSSE isolated (1.5 +- 0.2 femtomoles/cell) could only account for 28.5 +- 4.3% of the total ASF thiols.	Sulfhydryl Compounds	158-164	arylsulfatase F	Homo sapiens	154-157
24281108-7	2010	A large proportion of the 35S labeled components, obtained after reaction of the ASF thiols with the Ellman reagent, did not form mixed aromatic disulfides and could therefore not be identified by this labeling method.	Sulfhydryl Compounds	85-91	arylsulfatase F	Homo sapiens	81-84
20079872-1	2010	ERp57 is a 58-kDa thiol oxidoreductase and a member of the protein disulfide isomerase (PDI)-like family.	Sulfhydryl Compounds	18-23	protein disulfide isomerase family A member 3	Homo sapiens	0-5
20044026-5	2010	Thiol-mediated retention of adiponectin occurs during transit through the ER, via direct interactions with chaperones including ERp44 and DsbA-L, and facilitates multimerisation and secretion.	Sulfhydryl Compounds	0-5	adiponectin, C1Q and collagen domain containing	Homo sapiens	28-39
20044026-5	2010	Thiol-mediated retention of adiponectin occurs during transit through the ER, via direct interactions with chaperones including ERp44 and DsbA-L, and facilitates multimerisation and secretion.	Sulfhydryl Compounds	0-5	endoplasmic reticulum protein 44	Homo sapiens	128-133
20433150-4	2010	Comparison of SAMs generated from the above aromatic thiols to well-known SAMs generated from the alkanethiol dodecanethiol revealed that the former aromatic SAMs are densely packed and highly vertically oriented, with a slightly higher packing density and a absence of molecular inclination in TPMT/Au.	Sulfhydryl Compounds	53-59	thiopurine S-methyltransferase	Homo sapiens	295-299
20413649-5	2010	Cleavage of this bond by thioredoxin f produces the fully active thiol form, releasing autoinhibition.	Sulfhydryl Compounds	65-70	LOC101027257	Zea mays	25-36
20361855-7	2010	Reversible oxidation of thiols in serine threonine protein phosphatase PP2A and in protein tyrosin phosphatases SHP1, SHP2 and CD45 leads to their inactivation generally by formation of intramolecular disulfides.	Sulfhydryl Compounds	24-30	protein phosphatase 2 phosphatase activator	Homo sapiens	71-75
20361855-7	2010	Reversible oxidation of thiols in serine threonine protein phosphatase PP2A and in protein tyrosin phosphatases SHP1, SHP2 and CD45 leads to their inactivation generally by formation of intramolecular disulfides.	Sulfhydryl Compounds	24-30	nuclear receptor subfamily 0 group B member 2	Homo sapiens	112-116
20361855-7	2010	Reversible oxidation of thiols in serine threonine protein phosphatase PP2A and in protein tyrosin phosphatases SHP1, SHP2 and CD45 leads to their inactivation generally by formation of intramolecular disulfides.	Sulfhydryl Compounds	24-30	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	118-122
20361855-7	2010	Reversible oxidation of thiols in serine threonine protein phosphatase PP2A and in protein tyrosin phosphatases SHP1, SHP2 and CD45 leads to their inactivation generally by formation of intramolecular disulfides.	Sulfhydryl Compounds	24-30	protein tyrosine phosphatase receptor type C	Homo sapiens	127-131
20361993-3	2010	Native insulin is subject to thermal denaturation in the presence and in the absence of thiol catalysts.	Sulfhydryl Compounds	88-93	insulin	Homo sapiens	7-14
20601738-1	2010	Thioredoxin (TRX) is a protein disulfide reductase that plays an important role in many thiol-dependent cellular reductive processes, antioxidant protection, and signal transduction.	Sulfhydryl Compounds	88-93	thioredoxin 1	Rattus norvegicus	0-11
20601738-1	2010	Thioredoxin (TRX) is a protein disulfide reductase that plays an important role in many thiol-dependent cellular reductive processes, antioxidant protection, and signal transduction.	Sulfhydryl Compounds	88-93	thioredoxin 1	Rattus norvegicus	13-16
20601738-4	2010	As a continuation of their studies, they hypothesized that alpha-lipoic acid, a natural thiol antioxidant, has a favorable effect on the brain TRX and glutathione (GSH) system in diabetes.	Sulfhydryl Compounds	88-93	thioredoxin 1	Rattus norvegicus	143-146
20375261-0	2010	Dietary selenium modulates activation and differentiation of CD4+ T cells in mice through a mechanism involving cellular free thiols.	Sulfhydryl Compounds	126-132	CD4 antigen	Mus musculus	61-64
20375261-8	2010	Addition of exogenous free thiols eliminated differences in CD4(+) T cell activation among the dietary groups.	Sulfhydryl Compounds	27-33	CD4 antigen	Mus musculus	60-63
21072382-4	2010	Thiol-containing molecular targets include the redox enzymes thioredoxin reductase and glutathione reductase, transcription factors, and cysteine proteases such as caspases and cathepsins.	Sulfhydryl Compounds	0-5	peroxiredoxin 5	Homo sapiens	61-82
21072382-4	2010	Thiol-containing molecular targets include the redox enzymes thioredoxin reductase and glutathione reductase, transcription factors, and cysteine proteases such as caspases and cathepsins.	Sulfhydryl Compounds	0-5	glutathione-disulfide reductase	Homo sapiens	87-108
20407696-1	2010	Self-assembled monolayers (SAMs) of functionalized thiols are widely used in organic (opto)electronic devices to tune the work function, Phi, of noble-metal electrodes and, thereby, to optimize the barriers for charge-carrier injection.	Sulfhydryl Compounds	51-57	glucose-6-phosphate isomerase	Homo sapiens	137-140
20235151-7	2010	Moreover, arsenic enhanced the activity of immunoprecipitated RET protein with increase in thiol-dependent dimer formation.	Sulfhydryl Compounds	91-96	ret proto-oncogene	Homo sapiens	62-65
20407696-2	2010	The achievable Phi values not only depend on the intrinsic molecular dipole moment of the thiols but, importantly, also on the bond dipole at the Au-S interface.	Sulfhydryl Compounds	90-96	glucose-6-phosphate isomerase	Homo sapiens	15-18
20144905-0	2010	Thiol-disulfide exchanges modulate aldo-keto reductase family 1 member B10 activity and sensitivity to inhibitors.	Sulfhydryl Compounds	0-5	aldo-keto reductase family 1 member B10	Homo sapiens	35-74
20225883-5	2010	The study of thiols with functionalized end groups (-CF(3), -OH, -SH, -COOH, and -NH(2)) gave specific insights in orientation, packing, and structure of the molecules in the SAMs.	Sulfhydryl Compounds	13-19	methionine adenosyltransferase 1A	Homo sapiens	175-179
19941984-1	2010	Peroxiredoxin I (Prx I) belongs to a family of proteins with thiol-dependent peroxidase activity and is involved in the cellular protection against oxidative stress, the modulation of intracellular signalling cascades as well as the regulation of cell proliferation and apoptosis.	Sulfhydryl Compounds	61-66	peroxiredoxin 1	Mus musculus	0-15
19941984-1	2010	Peroxiredoxin I (Prx I) belongs to a family of proteins with thiol-dependent peroxidase activity and is involved in the cellular protection against oxidative stress, the modulation of intracellular signalling cascades as well as the regulation of cell proliferation and apoptosis.	Sulfhydryl Compounds	61-66	peroxiredoxin 1	Mus musculus	17-22
20213169-2	2010	After the modification has been confirmed by UV-vis spectroscopy and ESI-MS, N-linked cytochrome c is then covalently assembled onto the surface of a gold electrode via the resulted homocysteine thiol group, thus electrochemical techniques, especially differential pulse voltammetry, have been employed and proven to provide an efficient way to probe into the modification of the protein.	Sulfhydryl Compounds	195-200	cytochrome c, somatic	Equus caballus	86-98
20144905-6	2010	Together our results showed for the first time that AKR1B10"s enzymatic activity and inhibitor sensitivity are modulated by thiol/disulfide exchanges.	Sulfhydryl Compounds	124-129	aldo-keto reductase family 1 member B10	Homo sapiens	52-59
20074597-5	2010	OVA was covalently linked to TMC using thiol chemistry (SPDP method).	Sulfhydryl Compounds	39-44	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-3
20132882-8	2010	These functional effects were associated with oxidative modification of thiols on both SERCA and NCX.	Sulfhydryl Compounds	72-78	solute carrier family 8 member A1	Rattus norvegicus	97-100
20144705-0	2010	Thiol-sensitive mutant forms of human SOD2, L60F, and I58T: the role of Cys140.	Sulfhydryl Compounds	0-5	superoxide dismutase 2	Homo sapiens	38-42
20511297-0	2010	Plastidial thioredoxin z interacts with two fructokinase-like proteins in a thiol-dependent manner: evidence for an essential role in chloroplast development in Arabidopsis and Nicotiana benthamiana.	Sulfhydryl Compounds	76-81	thioredoxin H-type 1	Arabidopsis thaliana	11-22
20302345-7	2010	Since the gold-thiol link is less stable at elevated temperatures, the adsorption capacity is recovered by washing the column at 80 degrees C for 2 h. While regeneration is easy, the multiplicity of bonds between the monolithic support and the gold nanoparticles prevents their elution even under harsh conditions such as treatment with pure 2-mercaptoethanol or treatment with boiling water for 5 h. Application of the gold modified monolith in tandem with a packed C18 capillary column is demonstrated with baseline separation of a peptide mixture achieved in a two step process.	Sulfhydryl Compounds	15-20	Bardet-Biedl syndrome 9	Homo sapiens	467-470
20398364-0	2010	HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way.	Sulfhydryl Compounds	83-88	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
20398364-8	2010	CONCLUSIONS: Our results disclose a novel action of celastrol-- causing cell cycle arrest at G0/G1 phase based upon thiol-related HSP90 inhibition.	Sulfhydryl Compounds	116-121	heat shock protein 90 alpha family class A member 1	Homo sapiens	130-135
20079424-0	2010	Modulation of CTNS gene expression by intracellular thiols.	Sulfhydryl Compounds	52-58	cystinosin, lysosomal cystine transporter	Homo sapiens	14-18
20192244-7	2010	Our work demonstrates the proof-of-principle that NAC pretreatment is effective at dampening acute episodes of oxidative stress by reversible perturbations in global metabolism that can provide deeper insight into the mechanisms of thiol-specific protein inhibition relevant to its successful translation as a prophylaxis in clinical medicine.	Sulfhydryl Compounds	232-237	X-linked Kx blood group	Homo sapiens	50-53
20354123-1	2010	Peroxiredoxins (PRDX) are a family of thiol-dependent peroxidases.	Sulfhydryl Compounds	38-43	peroxiredoxin 6	Homo sapiens	0-14
19876717-7	2010	Among the identified proteins, the expression levels of protein disulfide-isomerase and thiol-specific antioxidant protein were down-regulated in groups C and D, and two protein spots of annexin I were identified, one of which was down-regulated and another up-regulated in groups C and D. CONCLUSIONS: Preliminary proteome changes in PMN from rabbits experiencing scald injury and S. aureus sepsis were revealed, which possibly play an important role in the inflammation and pathogenesis of sepsis after scald injury.	Sulfhydryl Compounds	88-93	annexin A1	Oryctolagus cuniculus	187-196
20354123-1	2010	Peroxiredoxins (PRDX) are a family of thiol-dependent peroxidases.	Sulfhydryl Compounds	38-43	peroxiredoxin 6	Homo sapiens	16-20
20130111-6	2010	Moreover, treatment with sulfhydryl-modifying agents that oxidize SH-groups of cysteine residues to disulfide bonds abolished ATRA-mediated RARA nuclear localization, suggesting that the thiol oxidoreductase activity of GRp58 may be required for RARA nuclear import.	Sulfhydryl Compounds	25-35	retinoic acid receptor, alpha	Mus musculus	140-144
20130111-6	2010	Moreover, treatment with sulfhydryl-modifying agents that oxidize SH-groups of cysteine residues to disulfide bonds abolished ATRA-mediated RARA nuclear localization, suggesting that the thiol oxidoreductase activity of GRp58 may be required for RARA nuclear import.	Sulfhydryl Compounds	25-35	protein disulfide isomerase associated 3	Mus musculus	220-225
20130111-6	2010	Moreover, treatment with sulfhydryl-modifying agents that oxidize SH-groups of cysteine residues to disulfide bonds abolished ATRA-mediated RARA nuclear localization, suggesting that the thiol oxidoreductase activity of GRp58 may be required for RARA nuclear import.	Sulfhydryl Compounds	25-35	retinoic acid receptor, alpha	Mus musculus	246-250
19951731-5	2010	Affinity peptides capable of sequestering MCP-1 were identified from CCR2 (a G protein-coupled receptor for MCP-1) and incorporated within PEG hydrogels via a thiol-acrylate photopolymerization.	Sulfhydryl Compounds	159-164	C-C motif chemokine ligand 2	Homo sapiens	42-47
20026152-3	2010	The mechanism for this effect has been proposed to involve thiol-dependent modulation of Keap1, leading to loss of its ability to negatively regulate Nrf2.	Sulfhydryl Compounds	59-64	kelch like ECH associated protein 1	Homo sapiens	89-94
20026152-3	2010	The mechanism for this effect has been proposed to involve thiol-dependent modulation of Keap1, leading to loss of its ability to negatively regulate Nrf2.	Sulfhydryl Compounds	59-64	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
19951731-5	2010	Affinity peptides capable of sequestering MCP-1 were identified from CCR2 (a G protein-coupled receptor for MCP-1) and incorporated within PEG hydrogels via a thiol-acrylate photopolymerization.	Sulfhydryl Compounds	159-164	progestagen associated endometrial protein	Homo sapiens	139-142
20138526-2	2010	Inhibitor structure-activity relationships observed here for hMAGL and 2-ATG correlate well (r(2)=0.93, n=9) with earlier findings for mouse brain MAG hydrolase with non-thiol substrates.	Sulfhydryl Compounds	170-175	monoglyceride lipase	Homo sapiens	61-72
20036319-11	2010	Factor X activation by PDI and by Factor VIII was abolished by oxidation in an isolated system, which implies a possible role for thiol-disulphide exchange in the activity of the tenase complex.	Sulfhydryl Compounds	130-135	peptidyl arginine deiminase 1	Homo sapiens	23-26
20047825-3	2010	VEGF antibodies were cleaved into two half-fragments by 2-mercaptoethylamine-HCl (2-MEA) and the fragments were immobilized onto the Au NP substrates by their thiol groups.	Sulfhydryl Compounds	159-164	vascular endothelial growth factor A	Homo sapiens	0-4
20180610-2	2010	However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system.	Sulfhydryl Compounds	77-82	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	101-116
20084437-1	2010	The photoluminescence (PL) spectrum of water-soluble thiol-capped CdTe quantum dots (QDs) conjugated with Tat peptide in solution showed a remarkable redshift as compared to that of unconjugated QDs.	Sulfhydryl Compounds	53-58	tyrosine aminotransferase	Homo sapiens	106-109
20354834-8	2010	Plasma total thiols increased by 17% and directly correlated with EPO level (r = 0.528, P &lt; 0.05).	Sulfhydryl Compounds	13-19	erythropoietin	Homo sapiens	66-69
20180610-2	2010	However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system.	Sulfhydryl Compounds	77-82	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	118-121
20074557-1	2010	Thioredoxin (TRX) is a ubiquitous multifunctional thiol protein that is critically involved in maintaining cellular redox homeostasis.	Sulfhydryl Compounds	50-55	thioredoxin	Homo sapiens	0-11
20049866-7	2010	We show that the redox state of thiols is decisive for degradation of the extrinsic PsbO1 and PsbO2 subunits of photosystem II.	Sulfhydryl Compounds	32-38	PS II oxygen-evolving complex 1	Arabidopsis thaliana	84-89
20049866-7	2010	We show that the redox state of thiols is decisive for degradation of the extrinsic PsbO1 and PsbO2 subunits of photosystem II.	Sulfhydryl Compounds	32-38	photosystem II subunit O-2	Arabidopsis thaliana	94-99
20012373-6	2010	These results together indicate that upregulation of IDPc in response to hyperglycemia might play an essential role in preventing the progression of diabetic nephropathy, which is accompanied by ROS-induced cellular damage and fibrosis, by providing NADPH, the reducing equivalent needed for recycling reduced glutathione and low molecular weight antioxidant thiol proteins.	Sulfhydryl Compounds	359-364	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	53-57
20078027-4	2010	Then, the protecting group of the alpha-end, THP, was removed in mild acidic media, followed by two- or three-step modification of the resulting alpha-hydroxyl group to primary amino or thiol groups.	Sulfhydryl Compounds	186-191	uromodulin	Homo sapiens	45-48
19959476-9	2010	Whereas wild-type IGF-I undergoes thiol-catalyzed disulfide exchange to yield IGF-swap, His(B5)-IGF-I retains canonical pairing.	Sulfhydryl Compounds	34-39	insulin like growth factor 1	Homo sapiens	18-23
19963048-4	2010	Herein, evidences for a role of ADH3 in cell signaling through thiol homeostasis is highlighted, underscoring that the enzyme functions more broadly than to metabolize formaldehyde.	Sulfhydryl Compounds	63-68	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	32-36
19765857-2	2010	The aim of this study was to determine whether overexpression of either of two PC synthase (PCS) genes, AtPCS1 and CePCS in Nicotiana tabacum (previously shown to cause decrease and increase, respectively, of cadmium tolerance of tobacco - Wojas et al., 2008) also contributes to such contrasting phenotypes with respect to arsenic (As) tolerance and accumulation, and how observed responses relate to non-protein thiol (NPT) metabolism.	Sulfhydryl Compounds	414-419	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	104-110
20074557-1	2010	Thioredoxin (TRX) is a ubiquitous multifunctional thiol protein that is critically involved in maintaining cellular redox homeostasis.	Sulfhydryl Compounds	50-55	thioredoxin	Homo sapiens	13-16
19902935-2	2010	Here we report on the dynamics of release using fluorophore-terminated C6 or C11 thiols.	Sulfhydryl Compounds	81-87	RNA polymerase III subunit K	Homo sapiens	77-80
19902935-3	2010	We show that the release kinetics for C6 thiols are determined solely by diffusive transport, whereas for C11 thiols the release kinetics are attenuated by the low solubility that limits the rate at which the desorbed thiols can diffuse away from the surface.	Sulfhydryl Compounds	110-116	RNA polymerase III subunit K	Homo sapiens	106-109
19902935-3	2010	We show that the release kinetics for C6 thiols are determined solely by diffusive transport, whereas for C11 thiols the release kinetics are attenuated by the low solubility that limits the rate at which the desorbed thiols can diffuse away from the surface.	Sulfhydryl Compounds	110-116	RNA polymerase III subunit K	Homo sapiens	106-109
20044024-6	2010	Furthermore, thiol-containing compounds such as N-acetylcysteine, l-cysteine and monothioglycerol prevented Cyt C release, and hence induction of apoptosis.	Sulfhydryl Compounds	13-18	cytochrome c, somatic	Homo sapiens	108-113
20470939-8	2010	It was verified that the thiols groups were inversely correlated with apolipoprotein B and positively correlated with apolipoprotein A-I.	Sulfhydryl Compounds	25-31	apolipoprotein B	Homo sapiens	70-86
20470939-8	2010	It was verified that the thiols groups were inversely correlated with apolipoprotein B and positively correlated with apolipoprotein A-I.	Sulfhydryl Compounds	25-31	apolipoprotein A1	Homo sapiens	118-136
20164444-3	2010	Here, we show by associating TRX reductases (ntra ntrb) and glutathione biosynthesis (cad2) mutations that these two thiol reduction pathways interfere with developmental processes through modulation of auxin signaling.	Sulfhydryl Compounds	117-122	thioredoxin H-type 1	Arabidopsis thaliana	29-32
20164444-3	2010	Here, we show by associating TRX reductases (ntra ntrb) and glutathione biosynthesis (cad2) mutations that these two thiol reduction pathways interfere with developmental processes through modulation of auxin signaling.	Sulfhydryl Compounds	117-122	cinnamyl alcohol dehydrogenase homolog 2	Arabidopsis thaliana	86-90
20044024-7	2010	Taken together, these results suggest that PGA(2) activates intrinsic apoptotic pathway by directly stimulating mitochondrial outer membrane permeabilization to release Cyt C, in which thiol-reactivity of PGA(2) plays a pivotal role.	Sulfhydryl Compounds	185-190	cytochrome c, somatic	Homo sapiens	169-174
19854264-0	2010	Antioxidants rescue photoreceptors in rd1 mice: Relationship with thiol metabolism.	Sulfhydryl Compounds	66-71	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	38-41
19818593-2	2010	To construct the aptasensor, the sequence of the 15-base anti-thrombin DNA aptamer was split into two fragments, one of which was attached to a gold electrode via thiol self-assembled monolayer chemistry and the second of which was modified with the redox moiety ferrocene.	Sulfhydryl Compounds	163-168	coagulation factor II, thrombin	Homo sapiens	62-70
20058234-3	2010	The small thiol-group-specific reagent N-ethylmaleimide (NEM) was used to modify the cysteine residues in GalP(His)(6) both alone and in the presence of D-glucose, a known substrate.	Sulfhydryl Compounds	10-15	galanin like peptide	Homo sapiens	106-110
19909765-0	2010	The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats.	Sulfhydryl Compounds	17-22	gamma-glutamyltransferase 1	Rattus norvegicus	44-72
19879942-4	2010	This increase in ROS was blocked by overexpression of mitochondrial thioredoxin-2 (Trx2) in endothelial cells from Trx2-transgenic mice, suggesting that mitochondrial thiol antioxidant status plays a key role in this redox signaling mechanism.	Sulfhydryl Compounds	167-172	thioredoxin 2	Mus musculus	83-87
19879942-4	2010	This increase in ROS was blocked by overexpression of mitochondrial thioredoxin-2 (Trx2) in endothelial cells from Trx2-transgenic mice, suggesting that mitochondrial thiol antioxidant status plays a key role in this redox signaling mechanism.	Sulfhydryl Compounds	167-172	thioredoxin 2	Mus musculus	115-119
19854264-6	2010	Thiol contents and thiol-dependent peroxide metabolism seem to be directly related to the survival of photoreceptors in rd1 mouse retina.	Sulfhydryl Compounds	0-5	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	120-123
19854264-6	2010	Thiol contents and thiol-dependent peroxide metabolism seem to be directly related to the survival of photoreceptors in rd1 mouse retina.	Sulfhydryl Compounds	19-24	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	120-123
20000719-0	2010	Thiol-modified chitosan sulfate nanoparticles for protection and release of basic fibroblast growth factor.	Sulfhydryl Compounds	0-5	fibroblast growth factor 2	Homo sapiens	76-106
19833347-1	2010	Self-assembled monolayers of azobenzene-containing thiols on smooth Au(111) surfaces were studied by gap-mode surface-enhanced Raman spectroscopy (gap-mode SERS).	Sulfhydryl Compounds	51-57	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	156-160
19932100-0	2010	Adrenomedullin protects against hypoxia/reoxygenation-induced cell death by suppression of reactive oxygen species via thiol redox systems.	Sulfhydryl Compounds	119-124	adrenomedullin	Homo sapiens	0-14
19855060-1	2010	Nitric oxide (NO), synthesized by endothelial nitric oxide synthase (eNOS), exerts control over vascular function via two distinct mechanisms, the activation of soluble guanylate cyclase (sGC)/cGMP-dependent signaling or through S-nitrosylation of proteins with reactive thiols (S-nitrosylation).	Sulfhydryl Compounds	271-277	nitric oxide synthase 3	Homo sapiens	34-67
20000719-7	2010	L929 fibroblast culture tests showed that the thiol modified N,O-SOCC/CS nanoparticles could effectively protect bFGF from inactivation over a 120 h period.	Sulfhydryl Compounds	46-51	fibroblast growth factor 2	Homo sapiens	113-117
20000719-8	2010	The results of this study suggest that the thiol modified N,O-SOCC/CS nanoparticles may be useful as novel materials for specific delivery of bFGF with mitogenic activity.	Sulfhydryl Compounds	43-48	fibroblast growth factor 2	Homo sapiens	142-146
19800967-2	2010	TGF-beta increases reactive oxygen species production and decreases the concentration of glutathione (GSH), the most abundant intracellular free thiol and an important antioxidant, which mediates many of the fibrogenic effects of TGF-beta in various types of cells.	Sulfhydryl Compounds	145-150	transforming growth factor beta 1	Homo sapiens	0-8
20184147-1	2010	The capacity of nitrite, S-nitrosothiols (RS-NO), dinitrosyl iron complexes (DNICs) with thiol-containing ligands, and nitrosoamines to inhibit catalase has been used for the selective determination of these compounds in purely chemical systems and biological liquids: cow milk and colostram.	Sulfhydryl Compounds	34-39	catalase	Bos taurus	144-152
20410586-9	2010	Since hepsin contains disulfide bonds in the scavenger receptor cysteine-rich (SRCR) domain, it was suggested that the SRCR domain interacts with MGST1 leading to thiol/disulfide exchange between the two enzymes followed by disulfide-linked MGST1 dimer formation.	Sulfhydryl Compounds	163-168	hepsin	Rattus norvegicus	6-12
20410586-9	2010	Since hepsin contains disulfide bonds in the scavenger receptor cysteine-rich (SRCR) domain, it was suggested that the SRCR domain interacts with MGST1 leading to thiol/disulfide exchange between the two enzymes followed by disulfide-linked MGST1 dimer formation.	Sulfhydryl Compounds	163-168	microsomal glutathione S-transferase 1	Rattus norvegicus	146-151
20410586-9	2010	Since hepsin contains disulfide bonds in the scavenger receptor cysteine-rich (SRCR) domain, it was suggested that the SRCR domain interacts with MGST1 leading to thiol/disulfide exchange between the two enzymes followed by disulfide-linked MGST1 dimer formation.	Sulfhydryl Compounds	163-168	microsomal glutathione S-transferase 1	Rattus norvegicus	241-246
19641517-2	2010	Recently, it has been reported that the oxidation of cell surface thiols by an exogenous impermeant thiol oxidizer can phosphorylate p38 MAPK.	Sulfhydryl Compounds	66-72	mitogen-activated protein kinase 14	Mus musculus	133-141
23105888-8	2010	Protein thiols correlated positively with ceruloplasmin (r = 0.364, P&lt;0.001).	Sulfhydryl Compounds	8-14	ceruloplasmin	Homo sapiens	42-55
19949083-0	2010	Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner.	Sulfhydryl Compounds	53-58	toll like receptor 4	Homo sapiens	43-47
19949083-8	2010	SFN formed adducts with cysteine residues in the extracellular domain of TLR4 as confirmed by liquid chromatography-tandem mass spectrometry analysis and the inhibitory effects of SFN on oligomerization and NF-kappaB activation were reversed by thiol donors (DTT and N-acetyl-L-cysteine).	Sulfhydryl Compounds	245-250	toll like receptor 4	Homo sapiens	73-77
19949083-11	2010	Collectively, our results demonstrated that SFN downregulated TLR4 signaling through the suppression of oligomerization process in a thiol-dependent manner.	Sulfhydryl Compounds	133-138	toll like receptor 4	Homo sapiens	62-66
23105888-0	2010	Copper and ceruloplasmin levels in relation to total thiols and GST in type 2 diabetes mellitus patients.	Sulfhydryl Compounds	53-59	ceruloplasmin	Homo sapiens	11-24
20308784-2	2010	Bleomycin hydrolase (BLH), a thiol-dependent enzyme that has Hcy-thiolactonase (HTase) and aminopeptidease (APase) activities, has also been implicated in Alzheimer"s disease (AD).	Sulfhydryl Compounds	29-34	bleomycin hydrolase	Homo sapiens	0-19
19641517-2	2010	Recently, it has been reported that the oxidation of cell surface thiols by an exogenous impermeant thiol oxidizer can phosphorylate p38 MAPK.	Sulfhydryl Compounds	66-71	mitogen-activated protein kinase 14	Mus musculus	133-141
20609905-8	2010	Here, we introduce the central mechanism of thiol redox transition in cell signaling regulated by thioredoxin and related molecules.	Sulfhydryl Compounds	44-49	thioredoxin	Homo sapiens	98-109
19808700-8	2010	Furthermore, arsenic and free PAO significantly reduced the free thiol contents of purified or endogenous Keap1.	Sulfhydryl Compounds	65-70	kelch-like ECH-associated protein 1	Mus musculus	106-111
20513473-2	2010	Hydrogen peroxide, peroxynitrite, or lipid hydroperoxides are all able to oxidize cysteines to form cysteine sulfenic acids; this reactive intermediate can be directly reduced to thiol by cellular reductants such as thioredoxin or further participate in disulfide bond formation with glutathione or cysteine residues in the same or another protein.	Sulfhydryl Compounds	179-184	thioredoxin	Homo sapiens	216-227
20609908-1	2010	Protein thiols are an important component of mammalian intramitochondrial antioxidant defenses owing to their selective interaction with reactive oxygen and nitrogen species (ROS and RNS).	Sulfhydryl Compounds	8-14	FAM20C golgi associated secretory pathway kinase	Homo sapiens	183-186
20609905-0	2010	Thiol redox transitions by thioredoxin and thioredoxin-binding protein-2 in cell signaling.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	27-38
20609905-0	2010	Thiol redox transitions by thioredoxin and thioredoxin-binding protein-2 in cell signaling.	Sulfhydryl Compounds	0-5	thioredoxin interacting protein	Homo sapiens	43-72
20609905-3	2010	Thiol reduction is mainly controlled by the thioredoxin (TRX) system and glutathione (GSH) systems as scavengers of ROS and regulators of the protein redox states.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	44-55
20609905-3	2010	Thiol reduction is mainly controlled by the thioredoxin (TRX) system and glutathione (GSH) systems as scavengers of ROS and regulators of the protein redox states.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	57-60
20072908-4	2010	During bioconversion of nitroglycerin, and also in the presence of reactive oxygen and nitrogen species, the active site thiols of ALDH-2 are oxidized and the enzyme looses its activity.	Sulfhydryl Compounds	121-127	aldehyde dehydrogenase 2 family member	Homo sapiens	131-137
20609911-2	2010	The redox state of cysteine-34 of human albumin defines three fractions which allow to monitor albumin oxidation: mercaptalbumin with a free thiol group, nonmercaptalbumin1 containing a disulfide, and nonmercaptalbumin2 with a sulfinic or sulfonic acid group.	Sulfhydryl Compounds	141-146	albumin	Homo sapiens	40-47
20609912-6	2010	This newly discovered role of the redox protein of Trx in preconditioning-induced cell signaling and protection could lead to the development of new lead compounds for upregulation of Trx and related thiol redox proteins for cell survival, repair, proliferation, and neuronal plasticity.	Sulfhydryl Compounds	200-205	thioredoxin	Homo sapiens	51-54
20609912-6	2010	This newly discovered role of the redox protein of Trx in preconditioning-induced cell signaling and protection could lead to the development of new lead compounds for upregulation of Trx and related thiol redox proteins for cell survival, repair, proliferation, and neuronal plasticity.	Sulfhydryl Compounds	200-205	thioredoxin	Homo sapiens	184-187
20609913-10	2010	Here, we describe some of the contemporary methods used to study oxidative stress and thiol redox signaling involved in epigenetic (histone acetylation, deacetylation, and methylation) and chromatin remodeling (HAT, HDAC, SIRT1) research.	Sulfhydryl Compounds	86-91	sirtuin 1	Homo sapiens	222-227
19950928-0	2010	Inkless microcontact printing on SAMs of Boc- and TBS-protected thiols.	Sulfhydryl Compounds	64-70	methionine adenosyltransferase 1A	Homo sapiens	33-37
19950928-1	2010	We report a new inkless catalytic muCP technique that achieves accurate, fast, and complete pattern reproduction on SAMs of Boc- and TBS-protected thiols immobilized on gold using a polyurethane-acrylate stamp functionalized with covalently bound sulfonic acids.	Sulfhydryl Compounds	147-153	methionine adenosyltransferase 1A	Homo sapiens	116-120
22319269-5	2010	Recently we reported that both PKA and PKG can be regulated independently of their respective cyclic nucleotides via a mechanism whereby the kinases sense cellular oxidant production using redox active thiols.	Sulfhydryl Compounds	202-208	protein kinase cGMP-dependent 1	Homo sapiens	39-42
19537921-7	2010	The level of interleukin-6 (IL-6) was increased and positively correlated with thiol redox (r=0.423) in the preparatory period, whereas tumor necrosis factor alpha (TNFalpha) was increased and inversely correlated with thiol redox (r= 0.509) in the play-off round.	Sulfhydryl Compounds	79-84	interleukin 6	Homo sapiens	13-26
19537921-7	2010	The level of interleukin-6 (IL-6) was increased and positively correlated with thiol redox (r=0.423) in the preparatory period, whereas tumor necrosis factor alpha (TNFalpha) was increased and inversely correlated with thiol redox (r= 0.509) in the play-off round.	Sulfhydryl Compounds	79-84	interleukin 6	Homo sapiens	28-32
19537921-7	2010	The level of interleukin-6 (IL-6) was increased and positively correlated with thiol redox (r=0.423) in the preparatory period, whereas tumor necrosis factor alpha (TNFalpha) was increased and inversely correlated with thiol redox (r= 0.509) in the play-off round.	Sulfhydryl Compounds	219-224	tumor necrosis factor	Homo sapiens	136-163
19537921-7	2010	The level of interleukin-6 (IL-6) was increased and positively correlated with thiol redox (r=0.423) in the preparatory period, whereas tumor necrosis factor alpha (TNFalpha) was increased and inversely correlated with thiol redox (r= 0.509) in the play-off round.	Sulfhydryl Compounds	219-224	tumor necrosis factor	Homo sapiens	165-173
19919085-4	2009	Since previous work on human Ngb reported that its ligand binding properties could be controlled by the coordination state of the Fe(2+) atom (in the heme moiety) and the redox state of the thiol groups, we choose to develop a simulation approach combining coarse-grain Brownian dynamics and all-atom molecular dynamics and metadynamics.	Sulfhydryl Compounds	190-195	neuroglobin	Homo sapiens	29-32
19956548-5	2009	In addition, we used immuno-precipitation techniques to identify the central redox regulator thioredoxin, as one of the surface protein thiol targets modified by parthenolide.	Sulfhydryl Compounds	136-141	thioredoxin	Homo sapiens	93-104
19796678-7	2009	These results support the hypothesis that exposure of exponentially growing human breast and prostate epithelial cells to PCBs causes increased steady-state levels of intracellular O(2)(*-) and H(2)O(2), induction of MnSOD or CuZnSOD activity, and clonogenic cell killing that could be inhibited by a clinically relevant thiol antioxidant, NAC, as well as by catalase and superoxide dismutase after PCB exposure.	Sulfhydryl Compounds	321-326	superoxide dismutase 2	Homo sapiens	217-222
19796678-7	2009	These results support the hypothesis that exposure of exponentially growing human breast and prostate epithelial cells to PCBs causes increased steady-state levels of intracellular O(2)(*-) and H(2)O(2), induction of MnSOD or CuZnSOD activity, and clonogenic cell killing that could be inhibited by a clinically relevant thiol antioxidant, NAC, as well as by catalase and superoxide dismutase after PCB exposure.	Sulfhydryl Compounds	321-326	pyruvate carboxylase	Homo sapiens	122-125
19747817-2	2009	The thiol-terminated aptamer with 15 nucleotides (probe I) was first immobilized on Au electrode, and then thrombin was imported to form the aptamer-thrombin bioaffinity complexes.	Sulfhydryl Compounds	4-9	coagulation factor II, thrombin	Homo sapiens	107-115
19747817-2	2009	The thiol-terminated aptamer with 15 nucleotides (probe I) was first immobilized on Au electrode, and then thrombin was imported to form the aptamer-thrombin bioaffinity complexes.	Sulfhydryl Compounds	4-9	coagulation factor II, thrombin	Homo sapiens	149-157
19799602-9	2009	The main mechanism of E(2) protection in NaF exposure appeared to be connected with the influence of E(2 )on thiol group levels, not (*)OH scavenging ability.	Sulfhydryl Compounds	109-114	C-X-C motif chemokine ligand 8	Homo sapiens	41-44
19703554-4	2009	The thioredoxin (Trx) system promotes cell survival and has a major role in maintaining intracellular thiol redox balance.	Sulfhydryl Compounds	102-107	thioredoxin	Homo sapiens	4-15
19952498-6	2009	Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) analysis revealed Keap1 undergoes modification by such quinoid species through multiple reactive thiol groups.	Sulfhydryl Compounds	189-194	kelch-like ECH-associated protein 1	Mus musculus	110-115
19664619-1	2009	We investigated if the absence of glutaredoxin1, a critical protein thiol repair enzyme, increases lens susceptibility to oxidative stress caused by in vivo exposure to ultraviolet radiation type B (UVR-B).	Sulfhydryl Compounds	68-73	glutaredoxin	Mus musculus	34-47
19786557-3	2009	Modification of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Keap1), which congregates Nrf2 into the Keap1/Cul3 E3 complex for ubiquitination, is important but not sufficient for activation of Nrf2.	Sulfhydryl Compounds	25-30	kelch like ECH associated protein 1	Homo sapiens	74-109
19786557-3	2009	Modification of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Keap1), which congregates Nrf2 into the Keap1/Cul3 E3 complex for ubiquitination, is important but not sufficient for activation of Nrf2.	Sulfhydryl Compounds	25-30	kelch like ECH associated protein 1	Homo sapiens	111-116
19786557-3	2009	Modification of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Keap1), which congregates Nrf2 into the Keap1/Cul3 E3 complex for ubiquitination, is important but not sufficient for activation of Nrf2.	Sulfhydryl Compounds	25-30	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
19786557-3	2009	Modification of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Keap1), which congregates Nrf2 into the Keap1/Cul3 E3 complex for ubiquitination, is important but not sufficient for activation of Nrf2.	Sulfhydryl Compounds	25-30	kelch like ECH associated protein 1	Homo sapiens	151-156
19786557-3	2009	Modification of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Keap1), which congregates Nrf2 into the Keap1/Cul3 E3 complex for ubiquitination, is important but not sufficient for activation of Nrf2.	Sulfhydryl Compounds	25-30	cullin 3	Homo sapiens	157-161
19786557-3	2009	Modification of cysteine thiol groups by inducers in the linker region of Kelch-like ECH-associated protein-1 (Keap1), which congregates Nrf2 into the Keap1/Cul3 E3 complex for ubiquitination, is important but not sufficient for activation of Nrf2.	Sulfhydryl Compounds	25-30	NFE2 like bZIP transcription factor 2	Homo sapiens	243-247
19616568-12	2009	However, G6PD(-) erythrocytes suffered higher oxidative stress and depletion of thiols than normal erythrocytes due to primaquine toxicity.	Sulfhydryl Compounds	80-86	glucose-6-phosphate dehydrogenase	Homo sapiens	9-13
19703554-4	2009	The thioredoxin (Trx) system promotes cell survival and has a major role in maintaining intracellular thiol redox balance.	Sulfhydryl Compounds	102-107	thioredoxin	Homo sapiens	17-20
19627980-9	2009	The thiol donors, DTT and NAC, prevented the inhibitory effects of 4-HNE on TLR4 dimerization, and LC-MS/MS analysis showed that 4-HNE formed adducts with cysteine residues of synthetic peptides derived from TLR4.	Sulfhydryl Compounds	4-9	toll like receptor 4	Homo sapiens	76-80
19747166-7	2009	Interestingly, alkylation of the most reactive thiols of myosin by N-ethylmaleimide does not inhibit formation of a stable population of protein-SNOs, suggesting that these sites are located in less accessible regions of the protein than those that affect activity.	Sulfhydryl Compounds	47-53	myosin heavy chain 14	Homo sapiens	57-63
19627980-9	2009	The thiol donors, DTT and NAC, prevented the inhibitory effects of 4-HNE on TLR4 dimerization, and LC-MS/MS analysis showed that 4-HNE formed adducts with cysteine residues of synthetic peptides derived from TLR4.	Sulfhydryl Compounds	4-9	toll like receptor 4	Homo sapiens	208-212
19627980-10	2009	These observations suggest that the reactivity of 4-HNE with sulfhydryl moieties is implicated in the inhibition of TLR4 activation.	Sulfhydryl Compounds	61-71	toll like receptor 4	Homo sapiens	116-120
19734319-7	2009	Upregulation of HO-1 is not inhibited by Trolox, a non-thiol antioxidant, and does not involve the transcription factors AP-1 or Nrf2.	Sulfhydryl Compounds	55-60	heme oxygenase 1	Homo sapiens	16-20
19376195-8	2009	Beyond, the degenerate GSH specificity of GPx-4 allows selenylation and oxidation to disulfides of protein thiols.	Sulfhydryl Compounds	107-113	glutathione peroxidase 4	Homo sapiens	42-47
19592463-0	2009	Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice.	Sulfhydryl Compounds	0-5	low density lipoprotein receptor	Mus musculus	148-160
19734319-6	2009	Upregulation of HO-1 coincides with decreased intracellular glutathione (GSH) levels and can be inhibited by N-acetyl cysteine (NAC), a thiol antioxidant and GSH precursor.	Sulfhydryl Compounds	136-141	heme oxygenase 1	Homo sapiens	16-20
19725554-6	2009	Isolated adducts originate from the addition of the thiol group of NAc-Cys-OMe over the carbon-carbon double bonds of carvone.	Sulfhydryl Compounds	52-57	X-linked Kx blood group	Homo sapiens	67-70
19561443-5	2009	Because cytoplasmic gelsolin has 5 free thiol groups (cysteine), and its levels are increased in response to oxidative stress, we propose that gelsolin may serve as an antioxidant protein.	Sulfhydryl Compounds	40-45	gelsolin	Homo sapiens	20-28
19808809-10	2009	Characterization of the AtOPT6 substrate range provides a basis for investigating the possible physiological function of AtOPT6 in peptide signaling and thiol transport in response to stress.	Sulfhydryl Compounds	153-158	oligopeptide transporter 1	Arabidopsis thaliana	24-30
20158154-3	2009	The initiation stage is countered by phase II detoxification enzymes such as glutathione S-transferases (GST), quinine reductase (QR), epoxide hydrolase (mEH) besides conjugation with thiols.	Sulfhydryl Compounds	184-190	epoxide hydrolase 1, microsomal	Mus musculus	154-157
19754156-0	2009	Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.	Sulfhydryl Compounds	130-135	CF transmembrane conductance regulator	Homo sapiens	0-51
19754156-4	2009	CFTR constructs were screened for reactivity toward both channel-permeant and channel-impermeant thiol-directed reagents, and patterns of reactivity in TM6 were mapped onto two new, molecular models of the CFTR pore: one based on homology modeling using Sav1866 as the template and a second derived from the first by molecular dynamics simulation.	Sulfhydryl Compounds	97-102	CF transmembrane conductance regulator	Homo sapiens	0-4
19546033-3	2009	Hbb haplotype can be readily determined in all strains based on characteristic differences in peak profiles or on peak mobility shift induced by thiol exchange with glutathione disulfide in vitro.	Sulfhydryl Compounds	145-150	hemoglobin beta chain complex	Mus musculus	0-3
19806194-8	2009	In nearly all previously characterized NF-kappaB proteins, the analogous residue is fixed for Cys, and conversion of human RHD proteins from Cys to Ser at this site has been shown to increase DNA-binding ability and increase resistance to inhibition by thiol-reactive compounds.	Sulfhydryl Compounds	253-258	nuclear factor kappa B subunit 1	Homo sapiens	39-48
19806194-8	2009	In nearly all previously characterized NF-kappaB proteins, the analogous residue is fixed for Cys, and conversion of human RHD proteins from Cys to Ser at this site has been shown to increase DNA-binding ability and increase resistance to inhibition by thiol-reactive compounds.	Sulfhydryl Compounds	253-258	Rh blood group D antigen	Homo sapiens	123-126
19674406-7	2009	Interestingly, AtIPMDH1 activity is regulated by a thiol-based redox modification.	Sulfhydryl Compounds	51-56	isopropylmalate dehydrogenase 3	Arabidopsis thaliana	15-23
19563769-2	2009	Here we report studies on the reactivity of cysteinyl residues of the catalytic domain of PHD2 using an approach in which nondenaturing electrospray ionization-mass spectrometry (ESI-MS) analyses were combined with the use of a thiol library and residue substitution.	Sulfhydryl Compounds	228-233	egl-9 family hypoxia inducible factor 1	Homo sapiens	90-94
19563769-3	2009	Among the seven cysteinyl residues of the PHD2 catalytic domain, Cys201 was found to be predominantly modified by thiols or N-ethylmaleimide.	Sulfhydryl Compounds	114-120	egl-9 family hypoxia inducible factor 1	Homo sapiens	42-46
19561443-5	2009	Because cytoplasmic gelsolin has 5 free thiol groups (cysteine), and its levels are increased in response to oxidative stress, we propose that gelsolin may serve as an antioxidant protein.	Sulfhydryl Compounds	40-45	gelsolin	Homo sapiens	143-151
19388824-6	2009	Enzymatic mechanisms of ROS generation during UPR include: (a) Multiple thiol-disulfide exchanges involving ER oxidoreductases including flavooxidase Ero1 and protein disulfide isomerase (PDI); (b) Mitochondrial electron transport; (c) Nox4 NADPH oxidase complex, particularly Nox4.	Sulfhydryl Compounds	72-77	prolyl 4-hydroxylase subunit beta	Homo sapiens	159-186
19388824-6	2009	Enzymatic mechanisms of ROS generation during UPR include: (a) Multiple thiol-disulfide exchanges involving ER oxidoreductases including flavooxidase Ero1 and protein disulfide isomerase (PDI); (b) Mitochondrial electron transport; (c) Nox4 NADPH oxidase complex, particularly Nox4.	Sulfhydryl Compounds	72-77	prolyl 4-hydroxylase subunit beta	Homo sapiens	188-191
19766560-3	2009	(2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes neurogenesis.	Sulfhydryl Compounds	22-27	glycerophosphodiester phosphodiesterase domain containing 5	Homo sapiens	76-80
19797270-4	2009	PTMs induced by the electrophilic by-products of redox reactions most frequently occur at protein thiols; other nucleophilic amino acids serve as less favorable targets.	Sulfhydryl Compounds	98-104	parathymosin	Homo sapiens	0-4
19640848-1	2009	Light-induced structural changes at the entrance of the chromophore pocket of Agp1 phytochrome were investigated by using a thiol-reactive fluorescein derivative that is covalently attached to the genuine chromophore binding site (Cys-20) and serves as a polarity probe.	Sulfhydryl Compounds	124-129	orosomucoid 1	Homo sapiens	78-82
19743802-11	2009	Furthermore, Keap1, a scaffold protein to the actin cytoskeleton controlling cytoprotective enzyme genes, was also identified as another plausible target of the catechol type polyphenols by oxidative modification of the intracellular sulfhydryls.	Sulfhydryl Compounds	234-245	kelch like ECH associated protein 1	Homo sapiens	13-18
19592500-0	2009	Succination of thiol groups in adipose tissue proteins in diabetes: succination inhibits polymerization and secretion of adiponectin.	Sulfhydryl Compounds	15-20	adiponectin, C1Q and collagen domain containing	Mus musculus	121-132
19766560-3	2009	(2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes neurogenesis.	Sulfhydryl Compounds	22-27	peroxiredoxin 1	Homo sapiens	111-116
19766572-0	2009	The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.	Sulfhydryl Compounds	66-71	peroxiredoxin 1	Homo sapiens	23-28
19766572-0	2009	The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.	Sulfhydryl Compounds	66-71	glycerophosphodiester phosphodiesterase domain containing 5	Homo sapiens	102-106
19766572-4	2009	Prdx1 cooperates with GDE2 to drive motor neuron differentiation, and this synergy requires Prdx1 thiol-dependent catalysis.	Sulfhydryl Compounds	98-103	peroxiredoxin 1	Homo sapiens	0-5
19766572-4	2009	Prdx1 cooperates with GDE2 to drive motor neuron differentiation, and this synergy requires Prdx1 thiol-dependent catalysis.	Sulfhydryl Compounds	98-103	glycerophosphodiester phosphodiesterase domain containing 5	Homo sapiens	22-26
19766572-4	2009	Prdx1 cooperates with GDE2 to drive motor neuron differentiation, and this synergy requires Prdx1 thiol-dependent catalysis.	Sulfhydryl Compounds	98-103	peroxiredoxin 1	Homo sapiens	92-97
19404775-6	2009	Spleen-derived macrophages, dendritic cells (DC), and B cells constitutively express ART2.1 as their predominant ART while spleen T cells express both ART2.1 and the thiol-independent ART2.2 isoform.	Sulfhydryl Compounds	166-171	ADP-ribosyltransferase 2b	Mus musculus	184-190
19527783-6	2009	Purified fractions of cytochrome c and glyceraldehyde-3-phosphate dehydrogenase were conjugated to a known amount of biotin or BODIPY fluorophore to create an external standard that can be run on standard SDS-PAGE gels, which allows for the quantification of protein thiols from biological samples by Western blotting or fluorescence imaging.	Sulfhydryl Compounds	267-273	cytochrome c, somatic	Homo sapiens	22-34
19527742-4	2009	A sulfhydryl reducing agent, dithiothreitol at concentrations of 0.1, 1 and 5 mM also dose-dependently reversed the NH(2)Cl (5 microM)-induced XD/XO interconversion.	Sulfhydryl Compounds	2-12	xanthine dehydrogenase	Rattus norvegicus	143-145
19467228-5	2009	EPCR shedding was also induced by phorbol 12-myristate 13-acetate, ionomycin, anisomycin, thiol oxidants or alkylators, thrombin, and disruptors of lipid rafts.	Sulfhydryl Compounds	90-95	protein C receptor	Homo sapiens	0-4
19467228-6	2009	Both basal and induced shedding of EPCR was blocked by the metalloproteinase inhibitors, TAPI-0 and GM6001, and by the reduced non-protein thiols, glutathione, dihydrolipoic acid, dithiothreitol, and N-acetyl-l-cysteine.	Sulfhydryl Compounds	139-145	protein C receptor	Homo sapiens	35-39
19658411-5	2009	The nu(Fe-CO) and nu(C-O) data reveal that the proximal heme ligand of iNOS(P420) is consistent with a protonated thiol instead of a thiolate anion.	Sulfhydryl Compounds	114-119	nitric oxide synthase 2	Homo sapiens	71-75
19658411-7	2009	Together the data support the scenario that iNOS(P420) is inactivated by protonation of the native proximal thiolate ligand to a neutral thiol, instead of by ligand switching to a histidine, as prior studies have suggested.	Sulfhydryl Compounds	108-113	nitric oxide synthase 2	Homo sapiens	44-48
19882863-8	2009	The nitro compounds showing the properties of NO donors (RNO2) were determined as the substances that acquire the properties of DNIC in the presence of ferrous iron and thiols.	Sulfhydryl Compounds	169-175	NLR family pyrin domain containing 12	Homo sapiens	57-61
19453443-0	2009	ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis.	Sulfhydryl Compounds	76-81	proteasome alpha subunit F1	Arabidopsis thaliana	0-4
19453443-6	2009	Characterization of an independent paf1 T-DNA insertion allele and complementation by PAF1 confirmed that paf1 mutation is responsible for the enhanced thiol accumulation and arsenic tolerance phenotypes.	Sulfhydryl Compounds	152-157	proteasome alpha subunit F1	Arabidopsis thaliana	86-90
19453443-6	2009	Characterization of an independent paf1 T-DNA insertion allele and complementation by PAF1 confirmed that paf1 mutation is responsible for the enhanced thiol accumulation and arsenic tolerance phenotypes.	Sulfhydryl Compounds	152-157	proteasome alpha subunit F1	Arabidopsis thaliana	106-110
19453443-11	2009	The enhanced transcriptional response to arsenic and the increased accumulation of thiol compounds in ars5, compared with WT, suggest the presence of a positive regulation pathway for thiol biosynthesis that is enhanced in the ars5 background.	Sulfhydryl Compounds	83-88	proteasome alpha subunit F1	Arabidopsis thaliana	102-106
19453443-11	2009	The enhanced transcriptional response to arsenic and the increased accumulation of thiol compounds in ars5, compared with WT, suggest the presence of a positive regulation pathway for thiol biosynthesis that is enhanced in the ars5 background.	Sulfhydryl Compounds	83-88	proteasome alpha subunit F1	Arabidopsis thaliana	227-231
19453443-11	2009	The enhanced transcriptional response to arsenic and the increased accumulation of thiol compounds in ars5, compared with WT, suggest the presence of a positive regulation pathway for thiol biosynthesis that is enhanced in the ars5 background.	Sulfhydryl Compounds	184-189	proteasome alpha subunit F1	Arabidopsis thaliana	102-106
19453443-11	2009	The enhanced transcriptional response to arsenic and the increased accumulation of thiol compounds in ars5, compared with WT, suggest the presence of a positive regulation pathway for thiol biosynthesis that is enhanced in the ars5 background.	Sulfhydryl Compounds	184-189	proteasome alpha subunit F1	Arabidopsis thaliana	227-231
19482076-6	2009	Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells.	Sulfhydryl Compounds	159-164	haptoglobin-related protein	Homo sapiens	28-31
19482076-6	2009	Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells.	Sulfhydryl Compounds	159-164	AKT serine/threonine kinase 1	Homo sapiens	51-54
19595469-3	2009	Recently, the organotellurium compound, trichloro(dioxoethylene-O,O(")) tellurate (AS101), has been found by our group to be able to directly inhibit caspases, due to its Te(IV)-thiol chemistry.	Sulfhydryl Compounds	178-183	caspase 1	Mus musculus	150-158
19716472-2	2009	This ribozyme, called pR1, when derivatized with ribose 5-phosphate (PR) at its 3" terminus and incubated with 6-thioguanine, produces two interconverting thiol-containing products corresponding to a Schiff base and its Amadori rearranged product.	Sulfhydryl Compounds	155-160	transmembrane protein 37	Homo sapiens	22-25
19248796-1	2009	Three cytosolic phosphorolytic/arsenolytic enzymes, (purine nucleoside phosphorylase [PNP], glycogen phosphorylase, glyceraldehyde-3-phosphate dehydrogenase) have been shown to mediate reduction of arsenate (AsV) to the more toxic arsenite (AsIII) in a thiol-dependent manner.	Sulfhydryl Compounds	253-258	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	116-156
19596577-0	2009	Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.	Sulfhydryl Compounds	66-71	angiotensin I converting enzyme	Homo sapiens	77-80
19567874-5	2009	Furthermore, using differential thiol labeling and mass spectrometry, it was determined that hYVH1 forms intramolecular disulfide bonds at the catalytic cleft as well as within the zinc binding domain to avoid irreversible inactivation during severe oxidative stress.	Sulfhydryl Compounds	32-37	dual specificity phosphatase 12	Homo sapiens	93-98
19722686-6	2009	Treatment of the RBC with NEM, a thiol-alkylating reagent, resulted in modification of the thiol groups in the amino-terminal cytoplasmic domain (N-CPD) of the AE1, but not those in the membrane domain.	Sulfhydryl Compounds	91-96	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	160-163
19722686-8	2009	In addition, the treatment with TTN, a thiol-oxidizing reagent that forms intermolecular disulfide bonds, appeared to oxidize thiol groups in both the N-CPD and the membrane domain of AE1, which resulted in complete inhibition of the selenium export even during the initial period in which the export had a maximum velocity when using the thiol reagent-free treatment.	Sulfhydryl Compounds	39-44	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	184-187
19722686-8	2009	In addition, the treatment with TTN, a thiol-oxidizing reagent that forms intermolecular disulfide bonds, appeared to oxidize thiol groups in both the N-CPD and the membrane domain of AE1, which resulted in complete inhibition of the selenium export even during the initial period in which the export had a maximum velocity when using the thiol reagent-free treatment.	Sulfhydryl Compounds	126-131	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	184-187
19722686-8	2009	In addition, the treatment with TTN, a thiol-oxidizing reagent that forms intermolecular disulfide bonds, appeared to oxidize thiol groups in both the N-CPD and the membrane domain of AE1, which resulted in complete inhibition of the selenium export even during the initial period in which the export had a maximum velocity when using the thiol reagent-free treatment.	Sulfhydryl Compounds	126-131	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	184-187
19722686-10	2009	These inhibitory effects using NEM and TTN suggested that thiol groups in the integral protein AE1 play essential roles in the membrane transport of the selenium from the RBCs to the blood plasma.	Sulfhydryl Compounds	58-63	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	95-98
19596577-0	2009	Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors.	Sulfhydryl Compounds	66-71	membrane metalloendopeptidase	Homo sapiens	81-84
19549781-4	2009	Increased oxidation of Rpn1 and Rpn2 cysteine thiols was also found in lung extracts from mice in which catalase was inactivated, a condition associated with augmented intracellular concentrations of H2O2 and diminished 26 S proteasomal activity.	Sulfhydryl Compounds	46-52	ribophorin II	Mus musculus	32-36
19633417-8	2009	Interestingly, several of these compounds share the ability to target thiols and affect the redox state of p53, indicating that this is critical for mutant p53 rescue.	Sulfhydryl Compounds	70-76	tumor protein p53	Homo sapiens	156-159
19666611-7	2009	Polysome analyses and RNA co-immunoprecipitation experiments demonstrated the interconnection of the NAB1 thiol state and its activity as a translation repressor in vivo.	Sulfhydryl Compounds	106-111	uncharacterized protein	Chlamydomonas reinhardtii	101-105
19341824-8	2009	We find that p19 function is maximally compromised at high levels of thiol alkylation or in an oxidizing environment.	Sulfhydryl Compounds	69-74	interleukin 23 subunit alpha	Homo sapiens	13-16
19591457-9	2009	These results suggest that TPCK inhibits NF-kappaB activation by directly modifying thiol groups on two different targets: Cys-179 of IKKbeta and Cys-38 of p65/RelA.	Sulfhydryl Compounds	84-89	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	134-141
19591457-9	2009	These results suggest that TPCK inhibits NF-kappaB activation by directly modifying thiol groups on two different targets: Cys-179 of IKKbeta and Cys-38 of p65/RelA.	Sulfhydryl Compounds	84-89	RELA proto-oncogene, NF-kB subunit	Homo sapiens	160-164
19560437-3	2009	Addition of peroxynitrite to purified IR resulted in concentration-dependent tyrosine nitration and thiol oxidation.	Sulfhydryl Compounds	100-105	insulin receptor	Mus musculus	38-40
19363646-0	2009	Albumin thiol oxidation and serum protein carbonyl formation are progressively enhanced with advancing stages of chronic kidney disease.	Sulfhydryl Compounds	8-13	albumin	Homo sapiens	0-7
19363646-5	2009	As main markers of oxidative and carbonyl stresses, the redox state of Cys-34 (free thiol group) of human serum albumin [HSA(Cys-34)-redox] and the carbonyl content of serum proteins were employed, respectively.	Sulfhydryl Compounds	84-89	albumin	Homo sapiens	112-119
19372204-7	2009	CTSL also cleaved CgA in vitro, in time- and dose-dependent fashion, and specificity of the process was documented through E64 (thiol reagent) inhibition.	Sulfhydryl Compounds	128-133	cathepsin L	Rattus norvegicus	0-4
19671765-6	2009	We were further able to show that N-acetyl-L-cysteine, a thiol-containing free radical scavenger, partially protects MM cells from HYD1-induced death.	Sulfhydryl Compounds	57-62	msh homeobox 1	Homo sapiens	131-135
19583593-7	2009	However, recombinant GmPDIL-3a and GmPDIL-3b did not function as oxidoreductases or as molecular chaperones in vitro, although a proportion of each protein formed complexes in both thiol-dependent and thiol-independent ways in the ER.	Sulfhydryl Compounds	181-186	disulfide isomerase-like protein	Glycine max	21-30
19583593-7	2009	However, recombinant GmPDIL-3a and GmPDIL-3b did not function as oxidoreductases or as molecular chaperones in vitro, although a proportion of each protein formed complexes in both thiol-dependent and thiol-independent ways in the ER.	Sulfhydryl Compounds	201-206	disulfide isomerase-like protein	Glycine max	21-30
19583593-7	2009	However, recombinant GmPDIL-3a and GmPDIL-3b did not function as oxidoreductases or as molecular chaperones in vitro, although a proportion of each protein formed complexes in both thiol-dependent and thiol-independent ways in the ER.	Sulfhydryl Compounds	201-206	protein disulfide isomerase like protein	Glycine max	35-44
19474219-9	2009	Furthermore, the relative capacity of thiols to support AsV reduction mediated by PNP, GPa, PTA, and GAPDH apparently depended on the type of arsenylated metabolites (i.e., arsenate ester or anhydride) produced by these enzymes.	Sulfhydryl Compounds	38-44	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	101-106
19675666-9	2009	This multidisciplinary approach provides fresh insights into a universal thiol/disulfide exchange reaction mechanism that results in reduced substrate and oxidized Trx.	Sulfhydryl Compounds	73-78	thioredoxin	Homo sapiens	164-167
19478237-10	2009	Various thiols that differentially supported AsV reduction when present during PNP-catalyzed arsenolysis (DTT approximately dimercaptopropane-1-sulfonic acid &gt; mercaptoethanol &gt; DMSA &gt; GSH) similarly supported AsV reduction when added only after a transient PNP-catalyzed arsenolysis, which preformed ribose-1-arsenate.	Sulfhydryl Compounds	8-14	purine nucleoside phosphorylase	Homo sapiens	79-82
19478237-10	2009	Various thiols that differentially supported AsV reduction when present during PNP-catalyzed arsenolysis (DTT approximately dimercaptopropane-1-sulfonic acid &gt; mercaptoethanol &gt; DMSA &gt; GSH) similarly supported AsV reduction when added only after a transient PNP-catalyzed arsenolysis, which preformed ribose-1-arsenate.	Sulfhydryl Compounds	8-14	purine nucleoside phosphorylase	Homo sapiens	267-270
19478237-12	2009	In conclusion, phosphorolytic enzymes, such as PNP, GAPDH, GPa, and PTA, promote thiol-dependent AsV reduction because they convert AsV into arsenylated products reducible by thiols more readily than AsV.	Sulfhydryl Compounds	81-86	purine nucleoside phosphorylase	Homo sapiens	47-50
19478237-12	2009	In conclusion, phosphorolytic enzymes, such as PNP, GAPDH, GPa, and PTA, promote thiol-dependent AsV reduction because they convert AsV into arsenylated products reducible by thiols more readily than AsV.	Sulfhydryl Compounds	81-86	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	52-57
19478237-12	2009	In conclusion, phosphorolytic enzymes, such as PNP, GAPDH, GPa, and PTA, promote thiol-dependent AsV reduction because they convert AsV into arsenylated products reducible by thiols more readily than AsV.	Sulfhydryl Compounds	81-86	glycophorin A (MNS blood group)	Homo sapiens	59-62
19478237-12	2009	In conclusion, phosphorolytic enzymes, such as PNP, GAPDH, GPa, and PTA, promote thiol-dependent AsV reduction because they convert AsV into arsenylated products reducible by thiols more readily than AsV.	Sulfhydryl Compounds	175-181	purine nucleoside phosphorylase	Homo sapiens	47-50
19478237-12	2009	In conclusion, phosphorolytic enzymes, such as PNP, GAPDH, GPa, and PTA, promote thiol-dependent AsV reduction because they convert AsV into arsenylated products reducible by thiols more readily than AsV.	Sulfhydryl Compounds	175-181	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	52-57
19478237-12	2009	In conclusion, phosphorolytic enzymes, such as PNP, GAPDH, GPa, and PTA, promote thiol-dependent AsV reduction because they convert AsV into arsenylated products reducible by thiols more readily than AsV.	Sulfhydryl Compounds	175-181	glycophorin A (MNS blood group)	Homo sapiens	59-62
19474219-10	2009	Importantly, AsV reduction by both acetyl-arsenate-producing enzymes (i.e., PTA and GAPDH) exhibited striking similarities in responsiveness to various thiols, thus highlighting the role of arsenylated metabolite formation.	Sulfhydryl Compounds	152-158	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	84-89
19473966-0	2009	Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state.	Sulfhydryl Compounds	50-55	heme oxygenase 2	Homo sapiens	26-42
19473966-5	2009	In HO-2, the C-terminal HRMs constitute a thiol/disulfide redox switch that regulates affinity of the enzyme for heme (Yi, L., and Ragsdale, S. W. (2007) J. Biol.	Sulfhydryl Compounds	42-47	heme oxygenase 2	Homo sapiens	3-7
19473966-8	2009	Here, we demonstrate that the thiol/disulfide switch in human HO-2 is physiologically relevant.	Sulfhydryl Compounds	30-35	heme oxygenase 2	Homo sapiens	62-66
19473966-13	2009	Thus, the thiol/disulfide switch in HO-2 responds to cellular oxidative stress and reductive conditions, representing a paradigm for how HRMs can integrate heme homeostasis with CO signaling and redox regulation of cellular metabolism.	Sulfhydryl Compounds	10-15	heme oxygenase 2	Homo sapiens	36-40
19473973-8	2009	The thiol group of MD-2 also represents the target of environmental or endogenous thiol-reactive compounds that are produced in inflammation.	Sulfhydryl Compounds	4-9	lymphocyte antigen 96	Mus musculus	19-23
19641113-4	2009	Ensuing molecular studies demonstrated that lipoic acid inhibited recombinant Ca(V)3.2 channels heterologously expressed in human embryonic kidney 293 cells by oxidating specific thiol residues on the cytoplasmic face of the channel.	Sulfhydryl Compounds	179-184	immunoglobulin lambda variable 7-43	Homo sapiens	78-86
19473973-0	2009	Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation.	Sulfhydryl Compounds	5-10	lymphocyte antigen 96	Mus musculus	20-24
19473973-4	2009	Compounds with affinity for the hydrophobic pocket that contain a thiol-reactive group, which mediates covalent bond formation with the free cysteine residue of MD-2, were tested.	Sulfhydryl Compounds	66-71	lymphocyte antigen 96	Mus musculus	161-165
19473973-8	2009	The thiol group of MD-2 also represents the target of environmental or endogenous thiol-reactive compounds that are produced in inflammation.	Sulfhydryl Compounds	82-87	lymphocyte antigen 96	Mus musculus	19-23
19448671-1	2009	Thiol reactive cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ2), induced a novel, nonapoptotic and microtubule-associated protein 1 light chain 3 (MAP1 LC3) dependent but nonautophagic form of cell death in colon, breast and prostate cancer cell lines, characterized by extensive cytoplasmic vacuolation with dilatation of endoplasmic reticulum (ER).	Sulfhydryl Compounds	0-5	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	185-188
19462976-5	2009	In contrast, Prx 3 reacted very slowly with the thiol alkylating agents iodoacetamide and N-ethylmaleimide.	Sulfhydryl Compounds	48-53	periaxin	Homo sapiens	13-16
19397999-0	2009	Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation.	Sulfhydryl Compounds	12-17	glutathione-disulfide reductase	Homo sapiens	39-60
19348782-11	2009	In addition, the activity could be increased by thiol reagents (a hallmark of MGST1).	Sulfhydryl Compounds	48-53	microsomal glutathione S-transferase 1	Homo sapiens	78-83
19457862-6	2009	Activity assays carried out using a series of cysteine mutants and various reductants combined with measurements of free thiols under distinct oxidation conditions and mass spectrometry experiments show that the 2-Cys MSRB2 is reduced by Trx through a dithiol-disulfide exchange involving both redox-active Cys of the two partners.	Sulfhydryl Compounds	121-127	methionine sulfoxide reductase B 2	Arabidopsis thaliana	218-223
19383972-7	2009	The thiol form of C326 was essential for interaction with hepcidin, suggesting that C326-SH homology is located in or near the binding site of hepcidin.	Sulfhydryl Compounds	4-9	hepcidin antimicrobial peptide	Homo sapiens	58-66
19383972-7	2009	The thiol form of C326 was essential for interaction with hepcidin, suggesting that C326-SH homology is located in or near the binding site of hepcidin.	Sulfhydryl Compounds	4-9	hepcidin antimicrobial peptide	Homo sapiens	143-151
19426282-7	2009	Decreased glutathiolation of procaspase-3 was shown to be a link between protein thiol depletion and caspase-3 activation.	Sulfhydryl Compounds	15-20	caspase 3	Homo sapiens	29-41
18695935-2	2009	Recently it has been proposed that NAC administration may modify the plasma levels of low molecular weight thiols (LMW) like cysteine, homocysteine and glutathione, though it has been still debated if their plasma concentration increases or decreases during the therapy.	Sulfhydryl Compounds	107-113	X-linked Kx blood group	Homo sapiens	35-38
18695935-3	2009	Therefore research calls for methods able to analyze simultaneously NAC and the other plasma LMW thiols in order to evaluate if NAC is able to modify plasma thiols concentration and in particular to reduce homocysteine levels in hyperhomocysteinemia.	Sulfhydryl Compounds	157-163	X-linked Kx blood group	Homo sapiens	128-131
18695935-5	2009	The proposed method has been utilized to measure the drug and the physiological LMW thiols in NAC administered chronic obstructive broncho-pneumopathy (COPB) disease patients.	Sulfhydryl Compounds	84-90	X-linked Kx blood group	Homo sapiens	94-97
19375361-1	2009	Human erythrocyte peroxiredoxin 2 (Prx2) is a typical 2-cys cytosolic peroxiredoxin with thiol-dependent hydrogen peroxide scavenger activity.	Sulfhydryl Compounds	89-94	peroxiredoxin 2	Homo sapiens	18-33
19375361-1	2009	Human erythrocyte peroxiredoxin 2 (Prx2) is a typical 2-cys cytosolic peroxiredoxin with thiol-dependent hydrogen peroxide scavenger activity.	Sulfhydryl Compounds	89-94	peroxiredoxin 2	Homo sapiens	35-39
19426282-7	2009	Decreased glutathiolation of procaspase-3 was shown to be a link between protein thiol depletion and caspase-3 activation.	Sulfhydryl Compounds	15-20	caspase 3	Homo sapiens	32-41
19456123-0	2009	A new function of GAPDH from Chlamydomonas reinhardtii: a thiol-disulfide exchange reaction with CP12.	Sulfhydryl Compounds	58-63	uncharacterized protein	Chlamydomonas reinhardtii	97-101
19561608-3	2009	To localize the activation gate of these channels, we inserted cysteines along the S6 segment of mutant TRPV1 channels and assessed their accessibility to thiol-modifying agents.	Sulfhydryl Compounds	155-160	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-109
19453157-0	2009	Establishment of the C-NO bond dissociation energy scale in solution and its application in analyzing the trend of NO transfer from C-nitroso compound to thiols.	Sulfhydryl Compounds	154-160	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	21-25
19466722-9	2009	Moreover, the DFT results indicate that 1) any eta(6)-complexes from the acids RC(6)H(4)SO(3)H result from deprotonation of the acid, 2) complexation of the thiol, via the deprotonated sulfur atom, is preferred over complexation of the O atom of the sulfonate, RC(6)H(4)SO(3) (-) and 3) a sulfonate O-atom complex will be difficult to detect.	Sulfhydryl Compounds	157-162	endothelin receptor type A	Homo sapiens	47-50
19336478-8	2009	In control cells, the cysteines in this motif in SCO1 exist as a mixed population comprised of oxidized disulphides and reduced thiols; however, the relative ratio of oxidized to reduced cysteines in SCO1 is perturbed in cells from both SCO backgrounds.	Sulfhydryl Compounds	128-134	synthesis of cytochrome C oxidase 1	Homo sapiens	49-53
19496190-6	2009	Interestingly, when the thiol status of the cells was manipulated using BSO, the ethanol-induced activation of caspase-3 was abrogated.	Sulfhydryl Compounds	24-29	caspase 3	Homo sapiens	111-120
19453157-3	2009	The C-NO and S-NO bond thermodynamic parameters were used to predict the trend of NO transfer from C-nitroso substrates to thiols in acetonitrile solution.	Sulfhydryl Compounds	123-129	biogenesis of lysosomal organelles complex 1 subunit 4	Homo sapiens	4-8
19250966-6	2009	The pathway is redox-sensitive and oxidation of Tf thiols to disulfides induces release from Tf of highly reactive ferrous iron, which contributes to free radical production.	Sulfhydryl Compounds	51-57	coagulation factor III, tissue factor	Homo sapiens	48-50
19362581-2	2009	However, compared to other textbook proteins, progress in the study of beta LG has been slow because of obstacles such as a low reversibility from denaturation linked with thiol-disulfide exchange or monomer-dimer equilibrium preventing a detailed NMR analysis.	Sulfhydryl Compounds	172-177	beta-lactoglobulin	Bos taurus	71-78
19204972-7	2009	The new method offered the possibility to estimate equilibrium constants for the reaction of phenylarsine oxide with different thiol-containing biomolecules by means of the XIC peak areas of reactants and products.	Sulfhydryl Compounds	127-132	X chromosome inactivation center	Homo sapiens	173-176
19250966-6	2009	The pathway is redox-sensitive and oxidation of Tf thiols to disulfides induces release from Tf of highly reactive ferrous iron, which contributes to free radical production.	Sulfhydryl Compounds	51-57	coagulation factor III, tissue factor	Homo sapiens	93-95
19328186-3	2009	Trx acts as a powerful antioxidant and plays an important role in maintaining critical protein thiols in the reduced state.	Sulfhydryl Compounds	95-101	thioredoxin 1	Mus musculus	0-3
19349280-6	2009	Thiol modification with polyethylene glycol-maleimide showed disulfide bond formation at the active site of TRP32 in cells exposed to As(III).	Sulfhydryl Compounds	0-5	thioredoxin like 1	Homo sapiens	108-113
19402707-10	2009	Amine-directed coupling of the MFE-23 scFv reduced its immunoreactivity 20-fold which was resolved by site-specific polysialylation through an engineered C-terminal thiol residue.	Sulfhydryl Compounds	165-170	immunglobulin heavy chain variable region	Homo sapiens	38-42
19348471-4	2009	In this study, we investigated the splicing and labeling properties of various amino acids in the hinge domain between scFv and Mxe under thiol activation.	Sulfhydryl Compounds	138-143	immunglobulin heavy chain variable region	Homo sapiens	119-123
19233116-1	2009	Mycothiol (MSH) is the principal low-molecular-weight thiol, unique to mycobacteria and other actinomycetes, that performs a role analogous to glutathione found in other organisms.	Sulfhydryl Compounds	4-9	msh homeobox 2	Homo sapiens	11-14
19411067-4	2009	We show here that PRIMA-1 is converted to compounds that form adducts with thiols in mutant p53.	Sulfhydryl Compounds	75-81	proline rich membrane anchor 1	Homo sapiens	18-25
19411067-4	2009	We show here that PRIMA-1 is converted to compounds that form adducts with thiols in mutant p53.	Sulfhydryl Compounds	75-81	tumor protein p53	Homo sapiens	92-95
19018666-1	2009	Cox17, a copper chaperone for cytochrome-c oxidase, contains six conserved Cys residues and exists in three oxidative states, linked with two thiol-based redox switches.	Sulfhydryl Compounds	142-147	cytochrome c oxidase copper chaperone COX17	Homo sapiens	0-5
19350613-1	2009	We compare three structurally different classes of histone deacetylase (HDAC) inhibitors that contain benzamide, hydroxamate, or thiol groups as the zinc binding group (ZBG) for their ability to protect cortical neurons in culture from cell death induced by oxidative stress.	Sulfhydryl Compounds	129-134	histone deacetylase 9	Homo sapiens	51-70
19413661-9	2009	These results demonstrated that there are age-related changes in adenosine deaminase activity and that thiol agents may contribute to the maintenance of adenosine deaminase activity and may be important in the neuromodulation of adenosine.	Sulfhydryl Compounds	103-108	adenosine deaminase	Rattus norvegicus	153-172
19272349-0	2009	Effects of glutathione reductase inhibition on cellular thiol redox state and related systems.	Sulfhydryl Compounds	56-61	glutathione-disulfide reductase	Homo sapiens	11-32
19272349-1	2009	Although inhibition of glutathione reductase (GR) has been demonstrated to cause a decrease in reduced glutathione (GSH) and increase in glutathione disulfide (GSSG), a systematic study of the effects of GR inhibition on thiol redox state and related systems has not been noted.	Sulfhydryl Compounds	221-226	glutathione-disulfide reductase	Homo sapiens	46-48
19350613-1	2009	We compare three structurally different classes of histone deacetylase (HDAC) inhibitors that contain benzamide, hydroxamate, or thiol groups as the zinc binding group (ZBG) for their ability to protect cortical neurons in culture from cell death induced by oxidative stress.	Sulfhydryl Compounds	129-134	histone deacetylase 9	Homo sapiens	72-76
19281275-4	2009	In contrast, the activities of the whey proteins were dependent on denaturation or partial hydrolysis and dominated by the free thiol in beta-lg.	Sulfhydryl Compounds	128-133	beta-lactoglobulin	Bos taurus	137-144
19118843-0	2009	Monochloramine impairs caspase-3 through thiol oxidation and Zn2+ release.	Sulfhydryl Compounds	41-46	caspase-3	Oryctolagus cuniculus	23-32
19118843-1	2009	BACKGROUND: Caspase-3, a pro-apoptotic enzyme, represents a class of proteins in which the active site contains reduced thiol (S-H) groups and is modulated by heavy metal cations, such as Zn(2+).	Sulfhydryl Compounds	120-125	caspase-3	Oryctolagus cuniculus	12-21
19118843-8	2009	Caspase-3 activity was preserved by concurrent treatment with a thiol-reducing agent, dithiothreitol.	Sulfhydryl Compounds	64-69	caspase-3	Oryctolagus cuniculus	0-9
19118843-9	2009	CONCLUSIONS: At pathologically relevant concentrations, NH(2)Cl impairs caspase-3 activity through oxidation of its thiol groups.	Sulfhydryl Compounds	116-121	caspase-3	Oryctolagus cuniculus	72-81
19170994-3	2009	STUDY DESIGN AND METHODS: Anti-D that was shown to block 50 percent of the FcgammaR-mediated phagocytosis of opsonized red blood cells (RBCs) using a monocyte monolayer assay (MMA) was combined with two different thiol-containing compounds, dithiothreitol (DTT) or p-toluenesulfonylmethyl mercaptan, with or without treatment with iodoacetamide, and allowed to react.	Sulfhydryl Compounds	213-218	Fc gamma receptor Ia	Homo sapiens	75-83
19254690-2	2009	Thioredoxin (Trx) system, a major thiol antioxidant system, regulates the reduction of intracellular reactive oxygen species (ROS).	Sulfhydryl Compounds	34-39	thioredoxin	Homo sapiens	0-11
19254690-2	2009	Thioredoxin (Trx) system, a major thiol antioxidant system, regulates the reduction of intracellular reactive oxygen species (ROS).	Sulfhydryl Compounds	34-39	thioredoxin	Homo sapiens	13-16
19336037-6	2009	We propose that Vanabin2 forms a possible electron transfer cascade from the electron donor, NADPH, via glutathione reductase, glutathione, and Vanabin2 to the acceptor, and vanadium ions conjugated through thiol-disulfide exchange reactions.	Sulfhydryl Compounds	207-212	2,4-dienoyl-CoA reductase 1	Homo sapiens	93-98
19336037-6	2009	We propose that Vanabin2 forms a possible electron transfer cascade from the electron donor, NADPH, via glutathione reductase, glutathione, and Vanabin2 to the acceptor, and vanadium ions conjugated through thiol-disulfide exchange reactions.	Sulfhydryl Compounds	207-212	glutathione-disulfide reductase	Homo sapiens	104-125
18835362-7	2009	These results reveal both hemin-H(2)O(2)-NO(2)(-) and SIN-1 can cause inactivation of GDH through protein oxidation and tyrosine nitration, but the impact of the effect of protein oxidation (not thiol oxidation) on enzyme activity is stronger than that of protein tyrosine nitration.	Sulfhydryl Compounds	195-200	glutamate dehydrogenase 1	Homo sapiens	86-89
19238172-6	2009	In addition, in an in vitro mitochondria-free system, the thiol-oxidant diamide promotes auto-cleavage of caspase-9 and the caspase-9/Apaf-1 interaction by facilitating the formation of disulfide-linked complexes.	Sulfhydryl Compounds	58-63	caspase 9	Homo sapiens	106-115
19238172-6	2009	In addition, in an in vitro mitochondria-free system, the thiol-oxidant diamide promotes auto-cleavage of caspase-9 and the caspase-9/Apaf-1 interaction by facilitating the formation of disulfide-linked complexes.	Sulfhydryl Compounds	58-63	caspase 9	Homo sapiens	124-133
19238172-6	2009	In addition, in an in vitro mitochondria-free system, the thiol-oxidant diamide promotes auto-cleavage of caspase-9 and the caspase-9/Apaf-1 interaction by facilitating the formation of disulfide-linked complexes.	Sulfhydryl Compounds	58-63	apoptotic peptidase activating factor 1	Homo sapiens	134-140
19193675-1	2009	AIMS: Several studies have demonstrated that the mutant *2 allele of the CYP2C19 681G>A loss-of-function polymorphism is associated with diminished metabolization of clopidogrel into its active thiol metabolite and an attenuated platelet response to clopidogrel treatment.	Sulfhydryl Compounds	194-199	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	73-80
19291592-1	2009	Cytosolic NADP+-dependent isocitrate dehydrogenase (IDPc) is susceptible to inactivation by numerous thiol-modifying reagents.	Sulfhydryl Compounds	101-106	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	52-56
19132361-1	2009	We investigated conformational changes occurring in the C-linker and cyclic nucleotide-binding (CNB) domain of CNGA1 channels by analyzing the inhibition induced by thiol-specific reagents in mutant channels Q409C and A414C in the open and closed state.	Sulfhydryl Compounds	165-170	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	111-116
19299745-5	2009	Furthermore, minimal changes in surface-exposed CDR3 amino acids, even the addition of a single hydroxyl group or conversion of a methyl or sulfhydryl moiety to a hydroxyl, can confer modified Ag-specific TCR with new self-reactivity.	Sulfhydryl Compounds	140-150	cerebellar degeneration-related 3	Mus musculus	48-52
19336971-0	2009	Modification of cell-surface thiols elicits activation of human monocytic cell line THP-1: possible involvement in effect of haptens 2,4-dinitrochlorobenzene and nickel sulfate.	Sulfhydryl Compounds	29-35	GLI family zinc finger 2	Homo sapiens	84-89
19047760-7	2009	These results suggested that H-Rev107 is a hydrolase of the thiol type.	Sulfhydryl Compounds	60-65	phospholipase A and acyltransferase 3	Rattus norvegicus	29-37
19336971-7	2009	Next, we found that CD86 expression and macrophage inflammatory protein-1beta (MIP-1beta) production were augmented by the membrane-impermeable thiol blocker 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB), and these changes were suppressed by an inhibitor of the p38 MAPK pathway, SB203580.	Sulfhydryl Compounds	144-149	CD86 molecule	Homo sapiens	20-24
19216492-8	2009	To prove the plausible transformation of ITC from thiol to amine, synthetic AITC-conjugated N(alpha)-acetyl-L-cysteine (NAC) was incubated with BGK at 37 degrees C in physiological buffer, and the generation of AITC-Lys was analyzed.	Sulfhydryl Compounds	50-55	synuclein alpha	Homo sapiens	120-123
19336971-7	2009	Next, we found that CD86 expression and macrophage inflammatory protein-1beta (MIP-1beta) production were augmented by the membrane-impermeable thiol blocker 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB), and these changes were suppressed by an inhibitor of the p38 MAPK pathway, SB203580.	Sulfhydryl Compounds	144-149	C-C motif chemokine ligand 4	Homo sapiens	40-77
19336971-7	2009	Next, we found that CD86 expression and macrophage inflammatory protein-1beta (MIP-1beta) production were augmented by the membrane-impermeable thiol blocker 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB), and these changes were suppressed by an inhibitor of the p38 MAPK pathway, SB203580.	Sulfhydryl Compounds	144-149	C-C motif chemokine ligand 4	Homo sapiens	79-88
19336971-7	2009	Next, we found that CD86 expression and macrophage inflammatory protein-1beta (MIP-1beta) production were augmented by the membrane-impermeable thiol blocker 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB), and these changes were suppressed by an inhibitor of the p38 MAPK pathway, SB203580.	Sulfhydryl Compounds	144-149	mitogen-activated protein kinase 14	Homo sapiens	259-262
19336971-9	2009	Thus, our data indicate that the changes of cell-surface thiols are one of the triggers of maturation, and play a key role in activation of THP-1 cells by haptens.	Sulfhydryl Compounds	57-63	GLI family zinc finger 2	Homo sapiens	140-145
19223469-2	2009	IRP2 RNA-binding activity is primarily regulated by iron-mediated proteasomal degradation, but studies have suggested that IRP2 RNA binding is also regulated by thiol oxidation.	Sulfhydryl Compounds	161-166	iron responsive element binding protein 2	Homo sapiens	123-127
19343202-9	2009	Our findings demonstrate that PDI has two essential and independent roles in the process of chlamydial infectivity: it is structurally required for chlamydial attachment, and the thiol-mediated oxido-reductive function of PDI is necessary for entry.	Sulfhydryl Compounds	179-184	prolyl 4-hydroxylase subunit beta	Homo sapiens	30-33
19343202-9	2009	Our findings demonstrate that PDI has two essential and independent roles in the process of chlamydial infectivity: it is structurally required for chlamydial attachment, and the thiol-mediated oxido-reductive function of PDI is necessary for entry.	Sulfhydryl Compounds	179-184	prolyl 4-hydroxylase subunit beta	Homo sapiens	222-225
19185294-6	2009	Chemistry was developed to conjugate the PIA oligosaccharides to bovine serum albumin using a new heterobifunctional linker containing a thiol and an N-methylhydroxylamine functional group.	Sulfhydryl Compounds	137-142	RPTOR independent companion of MTOR complex 2	Homo sapiens	41-44
19251670-4	2009	To address this issue, we label cytochrome c site-specifically with a negatively charged Au nanoparticle via a covalent thiol-Au bond.	Sulfhydryl Compounds	120-125	cytochrome c, somatic	Homo sapiens	32-44
20357934-5	2009	These NMDA receptor-dependent effects are mediated in part by a coordinated program of gene expression changes centered on the thioredoxin-peroxiredoxin system, a thiol-based enzymatic system which is an important reducer of oxidative stressors such as hydroperoxides.	Sulfhydryl Compounds	163-168	thioredoxin	Homo sapiens	127-138
19061876-6	2009	Here we report that treatment of recombinant human AR (AKR1B1) by a non-thiol-based NO-donor (DEANO) results in activation and S-nitrosylation of the protein.	Sulfhydryl Compounds	72-77	aldo-keto reductase family 1 member B	Homo sapiens	55-61
19238297-4	2009	The PQQ electrode was then utilized as a thiol-specific sensor for the real-time monitoring of thiocholine generated from the hydrolysis of acetylthiocholine (ASCh) by acetylcholinesterase (AChE).	Sulfhydryl Compounds	41-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	168-188
19251091-1	2009	PURPOSE: Human peroxiredoxins (Prxs) are known as a family of thiol-specific antioxidant enzymes, among which Prx-I and -II play an important role in protecting cells from irradiation-induced cell death.	Sulfhydryl Compounds	62-67	peroxiredoxin 1	Homo sapiens	15-29
19251091-1	2009	PURPOSE: Human peroxiredoxins (Prxs) are known as a family of thiol-specific antioxidant enzymes, among which Prx-I and -II play an important role in protecting cells from irradiation-induced cell death.	Sulfhydryl Compounds	62-67	peroxiredoxin 1	Homo sapiens	110-123
19117943-10	2009	It can play a thiol stabilizer role preventing oxidative folding of the small Tim proteins and maintaining the proteins in an import-competent form.	Sulfhydryl Compounds	14-19	Rho guanine nucleotide exchange factor 5	Homo sapiens	78-81
19238297-4	2009	The PQQ electrode was then utilized as a thiol-specific sensor for the real-time monitoring of thiocholine generated from the hydrolysis of acetylthiocholine (ASCh) by acetylcholinesterase (AChE).	Sulfhydryl Compounds	41-46	acetylcholinesterase (Cartwright blood group)	Homo sapiens	190-194
19238297-6	2009	These measurements demonstrated the versatility of this sensor for the detection of thiols and potentially for the development of assays to evaluate the enzymatic activity of acetylcholinesterase.	Sulfhydryl Compounds	84-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	175-195
19118650-5	2009	These results indicate that inositol-P(6) increases the affinity of the sulphydryl for DTNB by increasing the population of the t isomer.	Sulfhydryl Compounds	72-82	dystrobrevin beta	Ovis aries	87-91
19059456-8	2009	Treatment of NADPH-reduced TrxR1 with TFs decreased 5-(Iodoacetamido) fluorescein incorporation, a fluorescent thiol-reactive reagent, suggesting that Sec/Cys residue(s) in the active site may be involved in the binding of TFs.	Sulfhydryl Compounds	111-116	thioredoxin reductase 1	Homo sapiens	27-32
19101643-7	2009	We concluded that dithiothreitol-induced activation of erythrocyte thiol status decreases NO efflux and allows greater intracellular NO mobilization onto different derivative molecules, both in the absence and presence of acetylcholinesterase substrate and inhibitor.	Sulfhydryl Compounds	67-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	222-242
19161974-1	2009	The oxidation of critical cysteines/related thiols of adenine nucleotide translocase (ANT) is believed to be an important event of the Ca(2+)-induced mitochondrial permeability transition (MPT), a process mediated by a cyclosporine A/ADP-sensitive permeability transition pores (PTP) opening.	Sulfhydryl Compounds	44-50	solute carrier family 25 member 6	Homo sapiens	86-89
19399252-1	2009	Oxidative protein folding is mediated by a proteinaceous electron relay system, in which the concerted action of protein disulfide isomerase and Ero1 delivers the electrons from thiol groups to the final acceptor.	Sulfhydryl Compounds	178-183	prolyl 4-hydroxylase subunit beta	Homo sapiens	113-140
19101643-1	2009	We assessed the redox thiol status influence on nitric oxide (NO) metabolism and efflux in erythrocytes stimulated with acetylcholinesterase substrate (acetylcholine, ACh) and inhibitor (velnacrine maleate, VM).	Sulfhydryl Compounds	22-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	120-140
19061912-5	2009	Acrylamide mainly interacted with the thiol (-SH) residue of CK-BB and resulted in alkylation.	Sulfhydryl Compounds	38-43	creatine kinase B	Homo sapiens	61-66
18988672-3	2009	Herein, we show that the cysteine residues of STAT3 are modified by a thiol-alkylating agent and are the targets of S-glutathionylation.	Sulfhydryl Compounds	70-75	signal transducer and activator of transcription 3	Homo sapiens	46-51
18988672-4	2009	STAT3 protein thiol reactivity was reversibly attenuated with concomitant increase in the S-glutathionylation of STAT3 upon treatment of human HepG2 hepatoma cells with pyrrolidine dithiocarbamate, glutathione disulfide, or diamide.	Sulfhydryl Compounds	14-19	signal transducer and activator of transcription 3	Homo sapiens	0-5
18988672-4	2009	STAT3 protein thiol reactivity was reversibly attenuated with concomitant increase in the S-glutathionylation of STAT3 upon treatment of human HepG2 hepatoma cells with pyrrolidine dithiocarbamate, glutathione disulfide, or diamide.	Sulfhydryl Compounds	14-19	signal transducer and activator of transcription 3	Homo sapiens	113-118
19034402-0	2009	A new redox-dependent mechanism of MMP-1 activity control comprising reduced low-molecular-weight thiols and oxidizing radicals.	Sulfhydryl Compounds	98-104	matrix metallopeptidase 1	Homo sapiens	35-40
19034402-3	2009	Here, using recombinant MMP-1, we investigated new redox-dependent mechanisms of proteinase activity regulation by low-molecular-weight thiols.	Sulfhydryl Compounds	136-142	matrix metallopeptidase 1	Homo sapiens	24-29
19141080-4	2009	The enhanced release of neuroprotective thiols and lactate by astrocytes in response to T cell stimulation is mimicked by both IL-4 and IFN-gamma.	Sulfhydryl Compounds	40-46	interleukin 4	Mus musculus	127-131
19034402-8	2009	We here offer a new concept of redox-sensitive control of MMP-1 activity based on the inhibitory effect of reduced thiols and reactivation by a mechanism comprising derivatization or oxidation of the MMP-1-bound inhibitory-acting thiol.	Sulfhydryl Compounds	115-121	matrix metallopeptidase 1	Homo sapiens	58-63
19141080-4	2009	The enhanced release of neuroprotective thiols and lactate by astrocytes in response to T cell stimulation is mimicked by both IL-4 and IFN-gamma.	Sulfhydryl Compounds	40-46	interferon gamma	Mus musculus	136-145
19034402-8	2009	We here offer a new concept of redox-sensitive control of MMP-1 activity based on the inhibitory effect of reduced thiols and reactivation by a mechanism comprising derivatization or oxidation of the MMP-1-bound inhibitory-acting thiol.	Sulfhydryl Compounds	115-120	matrix metallopeptidase 1	Homo sapiens	58-63
19141080-8	2009	Our studies with IFN-gamma and IL-4 suggest that a balanced Th1 and Th2 cytokine response might be needed for protecting two key astrocytic functions, glutamate clearance and thiol secretion and might be pertinent to neuroprotective approaches that are aimed at inhibition of an initial pro-inflammatory response to injury or its sustained boosting.	Sulfhydryl Compounds	175-180	interferon gamma	Mus musculus	17-26
19141080-8	2009	Our studies with IFN-gamma and IL-4 suggest that a balanced Th1 and Th2 cytokine response might be needed for protecting two key astrocytic functions, glutamate clearance and thiol secretion and might be pertinent to neuroprotective approaches that are aimed at inhibition of an initial pro-inflammatory response to injury or its sustained boosting.	Sulfhydryl Compounds	175-180	interleukin 4	Mus musculus	31-35
19304933-9	2009	It also led to great alterations in sulfur metabolism: the levels of sulfate and thiols increased in the apk1 apk2 plants.	Sulfhydryl Compounds	81-87	APS kinase	Arabidopsis thaliana	105-114
19141080-8	2009	Our studies with IFN-gamma and IL-4 suggest that a balanced Th1 and Th2 cytokine response might be needed for protecting two key astrocytic functions, glutamate clearance and thiol secretion and might be pertinent to neuroprotective approaches that are aimed at inhibition of an initial pro-inflammatory response to injury or its sustained boosting.	Sulfhydryl Compounds	175-180	negative elongation factor complex member C/D, Th1l	Mus musculus	60-63
19141080-8	2009	Our studies with IFN-gamma and IL-4 suggest that a balanced Th1 and Th2 cytokine response might be needed for protecting two key astrocytic functions, glutamate clearance and thiol secretion and might be pertinent to neuroprotective approaches that are aimed at inhibition of an initial pro-inflammatory response to injury or its sustained boosting.	Sulfhydryl Compounds	175-180	heart and neural crest derivatives expressed 2	Mus musculus	68-71
19151130-2	2009	Here, by characterization of T-DNA insertion lines of NTRC gene, we uncover a novel connection between chloroplast thiol redox regulation and the control of photoperiodic growth in Arabidopsis (Arabidopsis thaliana).	Sulfhydryl Compounds	115-120	NADPH-dependent thioredoxin reductase C	Arabidopsis thaliana	54-58
19199724-3	2009	The resulting ion-pair SAMs exhibit a 1:1 molar ratio of MHA:TAA+ on the surface and are covalently bound to the gold surface through the thiol headgroup of MHA.	Sulfhydryl Compounds	138-143	methionine adenosyltransferase 1A	Homo sapiens	23-27
18990697-9	2009	Liver and kidney of the MsrB1 knock-out mice also showed increased levels of malondialdehyde, protein carbonyls, protein methionine sulfoxide, and oxidized glutathione as well as reduced levels of free and protein thiols, whereas these parameters were little changed in other organs examined.	Sulfhydryl Compounds	214-220	methionine sulfoxide reductase B1	Mus musculus	24-29
19039312-0	2009	Thiol antioxidants regulate angiotensin II AT1 and arginine vasopressin V1 receptor functions differently in vascular smooth muscle cells.	Sulfhydryl Compounds	0-5	angiotensinogen	Rattus norvegicus	28-42
19201900-9	2009	These findings suggest that thiol-disulfide conversion occurring in the extracellular region of ADAM17 may be involved in its activation.	Sulfhydryl Compounds	28-33	ADAM metallopeptidase domain 17	Homo sapiens	96-102
19201900-10	2009	An analysis of ADAM17 revealed that within its disintegrin/cysteine-rich region are two highly conserved, vicinal cysteine sulfhydryl motifs (cysteine-X-X-cysteine), which are well-characterized targets for thiol-disulfide exchange in various other proteins.	Sulfhydryl Compounds	207-212	ADAM metallopeptidase domain 17	Homo sapiens	15-21
19039312-0	2009	Thiol antioxidants regulate angiotensin II AT1 and arginine vasopressin V1 receptor functions differently in vascular smooth muscle cells.	Sulfhydryl Compounds	0-5	angiotensin II receptor, type 1a	Rattus norvegicus	43-46
20353244-5	2009	The resulting exposed SH moieties have been further used for binding anti-A, -B, and -D IgM molecules from goat sera via a thiol exchange reaction involving the J chain and other disulfide bonds present in the IgM molecular structure.	Sulfhydryl Compounds	123-128	immunoglobulin J chain	Capra hircus	161-168
19039312-1	2009	BACKGROUND: We compared the effects of the sulfhydryl-containing (thiol) antioxidant dithiothreitol (DTT), which disrupts disulfide bonds, on cell signaling through angiotensin II (AngII) Type 1 receptors (AT1Rs) and arginine vasopressin (AVP) V1 receptors (V1Rs).	Sulfhydryl Compounds	43-53	angiotensinogen	Rattus norvegicus	165-179
19039312-1	2009	BACKGROUND: We compared the effects of the sulfhydryl-containing (thiol) antioxidant dithiothreitol (DTT), which disrupts disulfide bonds, on cell signaling through angiotensin II (AngII) Type 1 receptors (AT1Rs) and arginine vasopressin (AVP) V1 receptors (V1Rs).	Sulfhydryl Compounds	43-53	angiotensinogen	Rattus norvegicus	181-186
19039312-1	2009	BACKGROUND: We compared the effects of the sulfhydryl-containing (thiol) antioxidant dithiothreitol (DTT), which disrupts disulfide bonds, on cell signaling through angiotensin II (AngII) Type 1 receptors (AT1Rs) and arginine vasopressin (AVP) V1 receptors (V1Rs).	Sulfhydryl Compounds	66-71	angiotensinogen	Rattus norvegicus	165-179
19168513-2	2009	METHODS AND RESULTS: CTX at 800 mg/kg resulted in heart failure, in which cytoplasmic thioredoxin reductase (TrxR1) activity and non-protein free thiol (NPFT) level were suppressed by 90 and 62%, respectively.	Sulfhydryl Compounds	146-151	V-set and immunoglobulin domain containing 2	Mus musculus	21-24
19074570-2	2009	Thiol antioxidants including thioredoxin (TRX) and glutathione (GSH) have a crucial role in controlling cellular redox status.	Sulfhydryl Compounds	0-5	thioredoxin 1	Rattus norvegicus	29-40
19074570-2	2009	Thiol antioxidants including thioredoxin (TRX) and glutathione (GSH) have a crucial role in controlling cellular redox status.	Sulfhydryl Compounds	0-5	thioredoxin 1	Rattus norvegicus	42-45
19084589-7	2009	Importantly, the manganese-induced COX-2 expression was suppressed by treatment with the inhibitor of p38 MAPK (SB203580), PI3K/PKB (LY294002), PKCs (GO6983, GF109203X, Rottlerin), Src (PP1), or the thiol-containing compound (NAC).	Sulfhydryl Compounds	199-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
19108000-0	2009	Effect of structural parameters of peptides on dimer formation and highly oxidized side products in the oxidation of thiols of linear analogues of human beta-defensin 3 by DMSO.	Sulfhydryl Compounds	117-123	defensin beta 103B	Homo sapiens	153-168
18585819-6	2009	Treatment with thiol antioxidants, NAC and DTT, showed the recovery of GSH depletion and the reduction of O(2)(*-) levels in FCCP-treated cells, which were accompanied by the inhibition of apoptosis.	Sulfhydryl Compounds	15-20	synuclein alpha	Homo sapiens	35-38
19011861-0	2009	Increased thiol biosynthesis of transgenic poplar expressing a wheat O-acetylserine(thiol) lyase enhances resistance to hydrogen sulfide and sulfur dioxide toxicity.	Sulfhydryl Compounds	10-15	cysteine synthase	Triticum aestivum	69-96
19121228-9	2009	WhiB1 has a C37XXC40 motif thus a C40S mutation renders C37 to exist as a free thiol to form a hetero-disulfide bond with the cysteine residue of substrate protein.	Sulfhydryl Compounds	79-84	transcriptional regulator WhiB1	Mycobacterium tuberculosis H37Rv	0-5
19778251-8	2009	From the known facts and above findings, it is suggested that depletion of reduced glutathione by hydroquinone in the presence of copper in catalase active RBC may be due to the formation of 1, 4 benzoquinone adduct of reduced glutathione and to some extent due to binding of copper to the thiol group of reduced glutathione rather than conversion to oxidized glutathione via reactive oxygen species.	Sulfhydryl Compounds	290-295	catalase	Homo sapiens	140-148
19022369-5	2009	The gastroprotective action of CEB involved antisecretory action, augmentation of gastric mucus (48%) and participation of endogenous sulfhydryl compounds that increase efficacy of barrier mucosa against injurious agents.	Sulfhydryl Compounds	134-154	cathepsin E	Rattus norvegicus	31-34
18996185-10	2009	These results show that TXNRD1 may act as an important modifier gene of FALS and indicate that the additional thiol-redox system genes, thioredoxin and the peroxiredoxins, should also be investigated in FALS and other neurological disorders.	Sulfhydryl Compounds	110-115	thioredoxin reductase 1	Homo sapiens	24-30
19180612-0	2009	Formation of patches on 3D SAMs driven by thiols with immiscible chains observed by ESR spectroscopy.	Sulfhydryl Compounds	42-48	methionine adenosyltransferase 1A	Homo sapiens	27-31
18984580-3	2009	Based on the high resolution crystal structure of human leukotriene C4 synthase, a model of mPGES-1 has been constructed in which the tripeptide co-substrate glutathione is bound in a horseshoe-shaped conformation with its thiol group positioned in close proximity to Arg-126.	Sulfhydryl Compounds	223-228	prostaglandin E synthase	Mus musculus	92-99
18796561-4	2009	The early phase, coinciding with substantial thiol depletion, produces a cytosolic preparative complex, consisting of p50 and its interactor Bcl-3 linked by interprotein disulfide bridges.	Sulfhydryl Compounds	45-50	nuclear factor kappa B subunit 1	Homo sapiens	118-121
23045011-2	2009	Examination of thiol/disulfide redox changes in thioredoxin (Trx) family members including Trx1 in cytoplasm and nucleus and Trx2 in mitochondria should aid in the understanding of compartmentalized redox signaling mechanisms.	Sulfhydryl Compounds	15-20	thioredoxin	Homo sapiens	48-59
23045011-2	2009	Examination of thiol/disulfide redox changes in thioredoxin (Trx) family members including Trx1 in cytoplasm and nucleus and Trx2 in mitochondria should aid in the understanding of compartmentalized redox signaling mechanisms.	Sulfhydryl Compounds	15-20	thioredoxin	Homo sapiens	61-64
19388016-0	2009	A highly sensitive fluorescence probe for fast thiol-quantification assay of glutathione reductase.	Sulfhydryl Compounds	47-52	glutathione-disulfide reductase	Homo sapiens	77-98
18796561-4	2009	The early phase, coinciding with substantial thiol depletion, produces a cytosolic preparative complex, consisting of p50 and its interactor Bcl-3 linked by interprotein disulfide bridges.	Sulfhydryl Compounds	45-50	BCL3 transcription coactivator	Homo sapiens	141-146
19330636-8	2009	Upon heating beta-Lg at neutral pH, native dimer starts to dissociate into monomers leading to the exposure of previously buried hydrophobic amino acids and the free thiol group.	Sulfhydryl Compounds	166-171	beta-lactoglobulin	Bos taurus	13-20
19159822-1	2009	Dendritic cells are a major source of extracellular thiols needed for T cell activation, a process in which CD40-mediated stimulation plays a pivotal role.	Sulfhydryl Compounds	52-58	CD40 molecule	Homo sapiens	108-112
19159822-2	2009	The Dermatophagoides pteronyssinus group 1 mite allergen (Der p 1) has previously been shown to cleave CD40 from the surface of human dendritic cells, thereby suggesting that Der p 1 might compromise the ability of these cells to sustain thiol production during T cell activation.	Sulfhydryl Compounds	238-243	crystallin gamma F, pseudogene	Homo sapiens	39-42
19159822-2	2009	The Dermatophagoides pteronyssinus group 1 mite allergen (Der p 1) has previously been shown to cleave CD40 from the surface of human dendritic cells, thereby suggesting that Der p 1 might compromise the ability of these cells to sustain thiol production during T cell activation.	Sulfhydryl Compounds	238-243	CD40 molecule	Homo sapiens	103-107
19159822-2	2009	The Dermatophagoides pteronyssinus group 1 mite allergen (Der p 1) has previously been shown to cleave CD40 from the surface of human dendritic cells, thereby suggesting that Der p 1 might compromise the ability of these cells to sustain thiol production during T cell activation.	Sulfhydryl Compounds	238-243	crystallin gamma F, pseudogene	Homo sapiens	62-65
19159822-3	2009	This has therefore prompted us to examine the effect of the mite protease allergen Der p 1 on thiol production by human dendritic cells.	Sulfhydryl Compounds	94-99	crystallin gamma F, pseudogene	Homo sapiens	87-90
19159822-6	2009	Here, we show that Der p 1-mediated cleavage of CD40 from the surface of dendritic cells suppresses the ability of these cells to produce extracellular thiols, and that reducing thiols are needed for the generation of the T helper type 1 (Th1), T cytotoxic type 1 (Tc1) and T regulatory (Treg) cell phenotypes.	Sulfhydryl Compounds	152-158	crystallin gamma F, pseudogene	Homo sapiens	23-26
19159822-6	2009	Here, we show that Der p 1-mediated cleavage of CD40 from the surface of dendritic cells suppresses the ability of these cells to produce extracellular thiols, and that reducing thiols are needed for the generation of the T helper type 1 (Th1), T cytotoxic type 1 (Tc1) and T regulatory (Treg) cell phenotypes.	Sulfhydryl Compounds	152-158	CD40 molecule	Homo sapiens	48-52
19159822-6	2009	Here, we show that Der p 1-mediated cleavage of CD40 from the surface of dendritic cells suppresses the ability of these cells to produce extracellular thiols, and that reducing thiols are needed for the generation of the T helper type 1 (Th1), T cytotoxic type 1 (Tc1) and T regulatory (Treg) cell phenotypes.	Sulfhydryl Compounds	178-184	crystallin gamma F, pseudogene	Homo sapiens	23-26
19159822-6	2009	Here, we show that Der p 1-mediated cleavage of CD40 from the surface of dendritic cells suppresses the ability of these cells to produce extracellular thiols, and that reducing thiols are needed for the generation of the T helper type 1 (Th1), T cytotoxic type 1 (Tc1) and T regulatory (Treg) cell phenotypes.	Sulfhydryl Compounds	178-184	CD40 molecule	Homo sapiens	48-52
19159822-6	2009	Here, we show that Der p 1-mediated cleavage of CD40 from the surface of dendritic cells suppresses the ability of these cells to produce extracellular thiols, and that reducing thiols are needed for the generation of the T helper type 1 (Th1), T cytotoxic type 1 (Tc1) and T regulatory (Treg) cell phenotypes.	Sulfhydryl Compounds	178-184	transcobalamin 1	Homo sapiens	245-268
19159822-7	2009	We conclude that Der p 1-driven suppression of thiol production by dendritic cells may disrupt Th1/Tc1 and Treg cell development, and in doing so could lead to Th2/Tc2 cell responses and allergy.	Sulfhydryl Compounds	47-52	crystallin gamma F, pseudogene	Homo sapiens	21-24
19159822-7	2009	We conclude that Der p 1-driven suppression of thiol production by dendritic cells may disrupt Th1/Tc1 and Treg cell development, and in doing so could lead to Th2/Tc2 cell responses and allergy.	Sulfhydryl Compounds	47-52	transcobalamin 2	Homo sapiens	164-167
20155627-8	2009	The thiol reducing agent dithiothreitol abolished the inhibitory effects of piceatannol on NF-kappa B DNA binding activity, suggesting that piceatannol may directly modify NF-kappa B or its regulator through reaction with the cysteine thiol(s).	Sulfhydryl Compounds	4-9	nuclear factor kappa B subunit 1	Homo sapiens	91-101
20155627-8	2009	The thiol reducing agent dithiothreitol abolished the inhibitory effects of piceatannol on NF-kappa B DNA binding activity, suggesting that piceatannol may directly modify NF-kappa B or its regulator through reaction with the cysteine thiol(s).	Sulfhydryl Compounds	4-9	nuclear factor kappa B subunit 1	Homo sapiens	172-182
19053230-2	2008	Previously, we showed that the skeletal muscle ryanodine receptor (RyR1) has O(2)-sensitive thiols; only when these thiols are in the reduced state (pO(2) approximately 10 mmHg) can physiological concentrations of NO (nanomolar) activate RyR1.	Sulfhydryl Compounds	92-98	ryanodine receptor 1	Homo sapiens	31-65
20003713-1	2009	Peroxiredoxins are thiol-specific antioxidants that catalyze the reduction of cellular peroxides and protect cells from ROS-mediated damage and death.	Sulfhydryl Compounds	19-24	peroxiredoxin 6	Mus musculus	0-14
19006673-8	2009	In contrast, the role of hPCs in the detoxification mechanism to arsenate in soybean seems to be clearer, showing higher thiol concentrations and lower growth reductions than those present in lupin plants.	Sulfhydryl Compounds	121-126	PCS	Homo sapiens	25-29
19053233-4	2008	By incubating HEK293 cells stably transfected with CB2 receptors with the small, charged, hydrophilic, thiol-specific reagent methanethiosulfonate ethylammonium (MTSEA), [(3)H]CP55940 binding was significantly inhibited for six mutant receptors.	Sulfhydryl Compounds	103-108	cannabinoid receptor 2	Homo sapiens	51-54
19053230-2	2008	Previously, we showed that the skeletal muscle ryanodine receptor (RyR1) has O(2)-sensitive thiols; only when these thiols are in the reduced state (pO(2) approximately 10 mmHg) can physiological concentrations of NO (nanomolar) activate RyR1.	Sulfhydryl Compounds	92-98	ryanodine receptor 1	Homo sapiens	67-71
19053230-2	2008	Previously, we showed that the skeletal muscle ryanodine receptor (RyR1) has O(2)-sensitive thiols; only when these thiols are in the reduced state (pO(2) approximately 10 mmHg) can physiological concentrations of NO (nanomolar) activate RyR1.	Sulfhydryl Compounds	116-122	ryanodine receptor 1	Homo sapiens	31-65
19053230-2	2008	Previously, we showed that the skeletal muscle ryanodine receptor (RyR1) has O(2)-sensitive thiols; only when these thiols are in the reduced state (pO(2) approximately 10 mmHg) can physiological concentrations of NO (nanomolar) activate RyR1.	Sulfhydryl Compounds	116-122	ryanodine receptor 1	Homo sapiens	67-71
19053265-0	2008	Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl.	Sulfhydryl Compounds	14-20	phospholamban	Homo sapiens	0-13
19055324-1	2008	ENOX (ECTO-NOX) proteins are growth-related cell surface proteins that catalyze both hydroquinone or NADH oxidation and protein disulfide-thiol interchange and exhibit both prion-like and time-keeping (clock) properties.	Sulfhydryl Compounds	138-143	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	0-4
18989925-0	2008	Anti and syn glycolate aldol reactions with a readily displaced thiol auxiliary.	Sulfhydryl Compounds	64-69	synemin	Homo sapiens	9-12
18989925-1	2008	The TBDPS protected glycolate derivative of thiol auxiliary 1 is readily prepared (3 steps, 80% overall yield) and has been shown to give excellent anti:syn selectivity (&gt;97:3) and high facial selectivity (88:12 to 97:3) in glycolate aldol reactions with a range of aldehydes (75-87% isolated yield major diastereomer).	Sulfhydryl Compounds	44-49	synemin	Homo sapiens	153-156
18652572-7	2008	On consumption of the HSA (human serum albumin) free thiol group, the formation of stable (14)C-containing products and oxidation of tryptophan residues are observed.	Sulfhydryl Compounds	53-58	albumin	Homo sapiens	33-46
19360961-3	2008	Cysteine-containing ELPs were self-assembled on GNRs mediated by gold-thiol bonds, leading to the generation of GNR-ELP nanoassemblies.	Sulfhydryl Compounds	70-75	nuclear receptor subfamily 5 group A member 1	Homo sapiens	20-23
19053265-3	2008	The results show that activation of SERCA2a dephosphorylation by HNO is PLN-dependent and that PLN thiols are targets for HNO.	Sulfhydryl Compounds	99-105	phospholamban	Homo sapiens	95-98
18977105-6	2008	However, our finding showed that BAL, being a thiol, reduced the pentavalent arsenic compounds, As(V) to a trivalent state, As(III).	Sulfhydryl Compounds	46-51	solute carrier family 27 member 5	Rattus norvegicus	33-36
18980249-0	2008	Cell size increased in tissues from transgenic mice overexpressing a cell surface growth-related and cancer-specific hydroquinone oxidase, tNOX, with protein disulfide-thiol interchange activity.	Sulfhydryl Compounds	168-173	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	139-143
18980249-1	2008	tNOX (ENOX2), a cancer-specific and growth-related cell surface protein with protein disulfide-thiol interchange and hydroquinone (NADH) oxidase activities was overexpressed in a transgenic mouse model.	Sulfhydryl Compounds	95-100	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	0-4
18980249-1	2008	tNOX (ENOX2), a cancer-specific and growth-related cell surface protein with protein disulfide-thiol interchange and hydroquinone (NADH) oxidase activities was overexpressed in a transgenic mouse model.	Sulfhydryl Compounds	95-100	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	6-11
18992795-6	2008	The presence of thiol-containing compounds with PAT dramatically reduced the caspase 3 activity that was triggered by PAT; the addition of antioxidants, including mannitol and Tiron, had a similar effect.	Sulfhydryl Compounds	16-21	caspase 3	Homo sapiens	77-86
19216714-1	2008	Among the key antioxidant enzymes, thioredoxin and glutaredoxin systems play an important role in cell defense against oxidative stress and maintenance of redox homeostasis owing to the regulation of thiol-disulfide exchange.	Sulfhydryl Compounds	200-205	thioredoxin	Homo sapiens	35-46
19053310-0	2008	Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2.	Sulfhydryl Compounds	15-20	keratin 20	Homo sapiens	105-109
19053310-0	2008	Site-specific, thiol-mediated conjugation of fluorescent probes to cysteine-modified diabodies targeting CD20 or HER2.	Sulfhydryl Compounds	15-20	erb-b2 receptor tyrosine kinase 2	Homo sapiens	113-117
18840608-6	2008	The crystal structure of NO donor-reacted PTP1B at 2.6 A resolution revealed that the S-NO state at Cys-215 had no discernible irreversibly oxidized forms, whereas other Cys residues remained in their free thiol states.	Sulfhydryl Compounds	206-211	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	42-47
18991392-10	2008	On the basis of our observations, it is proposed that the function of Glu-469" is to facilitate the positioning of His-464" toward the interchange thiol, Cys-57, as suggested for the analogous residue in glutathione reductase.	Sulfhydryl Compounds	147-152	Thioredoxin reductase-1	Drosophila melanogaster	204-225
18704746-3	2008	These two forms of gelsolin differ from each other in length and in cysteinyl thiol groups.	Sulfhydryl Compounds	78-83	gelsolin	Mus musculus	19-27
19216714-1	2008	Among the key antioxidant enzymes, thioredoxin and glutaredoxin systems play an important role in cell defense against oxidative stress and maintenance of redox homeostasis owing to the regulation of thiol-disulfide exchange.	Sulfhydryl Compounds	200-205	glutaredoxin	Homo sapiens	51-63
19216714-4	2008	Glutaredoxin, whose major isoforms in mammals are Grx1, Grx2, and Grx5, as well as thioredoxin, catalyzes S-glutathionylation and deglutathionylation of proteins to protect SH-groups from oxidation and restore functionally active thiols.	Sulfhydryl Compounds	230-236	glutaredoxin	Homo sapiens	0-12
19216714-4	2008	Glutaredoxin, whose major isoforms in mammals are Grx1, Grx2, and Grx5, as well as thioredoxin, catalyzes S-glutathionylation and deglutathionylation of proteins to protect SH-groups from oxidation and restore functionally active thiols.	Sulfhydryl Compounds	230-236	glutaredoxin	Homo sapiens	50-54
19216714-4	2008	Glutaredoxin, whose major isoforms in mammals are Grx1, Grx2, and Grx5, as well as thioredoxin, catalyzes S-glutathionylation and deglutathionylation of proteins to protect SH-groups from oxidation and restore functionally active thiols.	Sulfhydryl Compounds	230-236	glutaredoxin 5	Homo sapiens	66-70
18718754-1	2008	Recombinant anti-morphine Fab" fragments have been immobilised on gold by covalent attachment through the free thiol groups of the fragment.	Sulfhydryl Compounds	111-116	FA complementation group B	Homo sapiens	26-29
19216714-4	2008	Glutaredoxin, whose major isoforms in mammals are Grx1, Grx2, and Grx5, as well as thioredoxin, catalyzes S-glutathionylation and deglutathionylation of proteins to protect SH-groups from oxidation and restore functionally active thiols.	Sulfhydryl Compounds	230-236	thioredoxin	Homo sapiens	83-94
18644727-1	2008	The melting curves of fatty acid amide hydrolase (FAAH) in the presence of 29 reversible inhibitors were measured using a thiol-reactive fluorophore.	Sulfhydryl Compounds	122-127	fatty acid amide hydrolase	Homo sapiens	22-48
19956788-4	2008	In the light of the structural features of histone deacetylase 8, we propose that the enzyme interacts with the gold nanoparticles via the surface exposed thiol groups, and such interaction occurs in two alternative modes.	Sulfhydryl Compounds	155-160	histone deacetylase 8	Homo sapiens	43-64
19020731-9	2008	We have identified thiol/selenol groups in the active site as reactive sites that mediated TrxR1 inhibition by EGCG.	Sulfhydryl Compounds	19-24	thioredoxin reductase 1	Homo sapiens	91-96
19124382-3	2008	Among the various antioxidants tried so far, thiol antioxidants and mucolytic agents, such as glutathione, N-acetyl-L-cysteine, N-acystelyn, erdosteine, fudosteine and carbocysteine; Nrf2 activators; and dietary polyphenols (curcumin, resveratrol, and green tea catechins/quercetin) have been reported to increase intracellular thiol status along with induction of GSH biosynthesis.	Sulfhydryl Compounds	45-50	NFE2 like bZIP transcription factor 2	Homo sapiens	183-187
18835810-2	2008	Here we demonstrate that thioredoxin reductase-1 (TR1), a selenium-containing pyridine nucleotide-disulfide oxidoreductase that reduces protein disulfides to free thiols, negatively regulates the activity of the HIV-1 encoded transcriptional activator, Tat, in human macrophages.	Sulfhydryl Compounds	163-169	thioredoxin reductase 1	Homo sapiens	50-53
18835810-2	2008	Here we demonstrate that thioredoxin reductase-1 (TR1), a selenium-containing pyridine nucleotide-disulfide oxidoreductase that reduces protein disulfides to free thiols, negatively regulates the activity of the HIV-1 encoded transcriptional activator, Tat, in human macrophages.	Sulfhydryl Compounds	163-169	Tat	Human immunodeficiency virus 1	253-256
18595691-2	2008	Organic hydroperoxides cause thiol-reversible, oxidative inactivation of PTP1B in a manner that mirrors the endogenous signaling agent hydrogen peroxide.	Sulfhydryl Compounds	29-34	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	73-78
18926709-6	2008	The only exception was seen for the thiol, glutathione, whose mixture with Cu(2+) mixture displayed a O2(*-)-generating capacity (cytochrome c- and lucigenin-reduction).	Sulfhydryl Compounds	36-41	cytochrome c, somatic	Homo sapiens	130-142
18845245-5	2008	In cancer cells, we show that NAC treatment produces an increase in specifically labeled reduced thiols of c-Src cysteines, thus confirming a redox transition.	Sulfhydryl Compounds	97-103	X-linked Kx blood group	Homo sapiens	30-33
18845245-5	2008	In cancer cells, we show that NAC treatment produces an increase in specifically labeled reduced thiols of c-Src cysteines, thus confirming a redox transition.	Sulfhydryl Compounds	97-103	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	107-112
18833192-5	2008	Competition between substrate thiols and Cys(131) creates a feedback loop where activation of Ero1alpha is linked to the availability of its substrate, reduced protein disulphide isomerase (PDI).	Sulfhydryl Compounds	30-36	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	94-103
18833192-5	2008	Competition between substrate thiols and Cys(131) creates a feedback loop where activation of Ero1alpha is linked to the availability of its substrate, reduced protein disulphide isomerase (PDI).	Sulfhydryl Compounds	30-36	prolyl 4-hydroxylase subunit beta	Homo sapiens	160-188
18833192-5	2008	Competition between substrate thiols and Cys(131) creates a feedback loop where activation of Ero1alpha is linked to the availability of its substrate, reduced protein disulphide isomerase (PDI).	Sulfhydryl Compounds	30-36	prolyl 4-hydroxylase subunit beta	Homo sapiens	190-193
19020013-10	2008	Through molecular modeling and site-directed mutagenesis, we predict that Cys 31 disrupts the disulfide bond between Cys 744 and Cys 798 on the NR1 subunit of the NMDA receptor by directly interacting with Cys 744 leading to a free thiol group on Cys 798 and subsequent persistent activation of the NMDA receptor.	Sulfhydryl Compounds	232-237	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	144-147
18644727-1	2008	The melting curves of fatty acid amide hydrolase (FAAH) in the presence of 29 reversible inhibitors were measured using a thiol-reactive fluorophore.	Sulfhydryl Compounds	122-127	fatty acid amide hydrolase	Homo sapiens	50-54
18629474-3	2008	However, a novel thiol, U25, was produced by MAR2 strain CNQ703 upon progression into stationary phase when secondary metabolite production occurred and became the dominant thiol.	Sulfhydryl Compounds	17-22	paternally expressed 10	Homo sapiens	45-49
18771724-5	2008	To investigate the functional modulation caused by binding of EGCG, we examined the interaction between EGCG and a thiol enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH).	Sulfhydryl Compounds	115-120	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	129-169
18771724-5	2008	To investigate the functional modulation caused by binding of EGCG, we examined the interaction between EGCG and a thiol enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH).	Sulfhydryl Compounds	115-120	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	171-176
18823135-0	2008	Toposelective electrochemical desorption of thiol SAMs from neighboring polycrystalline gold surfaces.	Sulfhydryl Compounds	44-49	methionine adenosyltransferase 1A	Homo sapiens	50-54
18629474-3	2008	However, a novel thiol, U25, was produced by MAR2 strain CNQ703 upon progression into stationary phase when secondary metabolite production occurred and became the dominant thiol.	Sulfhydryl Compounds	173-178	paternally expressed 10	Homo sapiens	45-49
18544680-5	2008	Thiol-disulfide exchange appears to contribute to the process based on the effects of thiol-reactive reagents and differences in thiol labeling of TGF-beta1 before and after stirring or shear.	Sulfhydryl Compounds	0-5	transforming growth factor, beta 1	Mus musculus	147-156
18544680-5	2008	Thiol-disulfide exchange appears to contribute to the process based on the effects of thiol-reactive reagents and differences in thiol labeling of TGF-beta1 before and after stirring or shear.	Sulfhydryl Compounds	129-134	transforming growth factor, beta 1	Mus musculus	147-156
18587424-3	2008	PMX464 is a novel thiol-reactive quinol thought to inhibit the Trx/TrxR system.	Sulfhydryl Compounds	18-23	thioredoxin	Homo sapiens	63-66
18587424-2	2008	Thioredoxin-1 (Trx) is a small, ubiquitous, redox-active thiol (-SH) protein that, with thioredoxin reductase-1 (TrxR), modifies the redox status of NF-kappaB pathway components.	Sulfhydryl Compounds	57-62	thioredoxin	Homo sapiens	0-13
18587424-3	2008	PMX464 is a novel thiol-reactive quinol thought to inhibit the Trx/TrxR system.	Sulfhydryl Compounds	18-23	thioredoxin reductase 1	Homo sapiens	67-71
18587424-2	2008	Thioredoxin-1 (Trx) is a small, ubiquitous, redox-active thiol (-SH) protein that, with thioredoxin reductase-1 (TrxR), modifies the redox status of NF-kappaB pathway components.	Sulfhydryl Compounds	57-62	thioredoxin	Homo sapiens	15-18
18587424-2	2008	Thioredoxin-1 (Trx) is a small, ubiquitous, redox-active thiol (-SH) protein that, with thioredoxin reductase-1 (TrxR), modifies the redox status of NF-kappaB pathway components.	Sulfhydryl Compounds	57-62	thioredoxin reductase 1	Homo sapiens	113-117
18661523-1	2008	Here we report that human nonsmall cell lung carcinomas overexpress macrophage migration inhibitory factor (MIF) and thioredoxin (Trx), 2 oxidoreductases with cytokine function, and contain more abundant nonprotein thiols (glutathione and cysteine) than nonneoplastic lung tissues.	Sulfhydryl Compounds	215-221	macrophage migration inhibitory factor	Homo sapiens	68-106
18462383-5	2008	Moreover, we demonstrate that Ure2p/Gln3p proteins mainly control the bioconversion of volatile thiols by the transcriptional regulation of the IRC7 gene through the general mechanism of nitrogen catabolic repression.	Sulfhydryl Compounds	96-102	glutathione peroxidase	Saccharomyces cerevisiae S288C	30-35
18462383-5	2008	Moreover, we demonstrate that Ure2p/Gln3p proteins mainly control the bioconversion of volatile thiols by the transcriptional regulation of the IRC7 gene through the general mechanism of nitrogen catabolic repression.	Sulfhydryl Compounds	96-102	nitrogen-responsive transcriptional regulator GLN3	Saccharomyces cerevisiae S288C	36-41
18462383-5	2008	Moreover, we demonstrate that Ure2p/Gln3p proteins mainly control the bioconversion of volatile thiols by the transcriptional regulation of the IRC7 gene through the general mechanism of nitrogen catabolic repression.	Sulfhydryl Compounds	96-102	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	144-148
19019026-0	2008	New insights into thiol-mediated regulation of adiponectin secretion.	Sulfhydryl Compounds	18-23	adiponectin, C1Q and collagen domain containing	Homo sapiens	47-58
19019026-4	2008	Within adipocytes, it is retained in the lumen of the endoplasmic reticulum by binding to the thiol protein ERp44 and released by another thiol protein, Ero1-Lalpha.	Sulfhydryl Compounds	94-99	endoplasmic reticulum protein 44	Homo sapiens	108-113
18662787-3	2008	This free thiol group has been shown to be responsible for the irreversibility of BLG denaturation in vitro, but nothing is known about its relevance during protein folding inside the cell.	Sulfhydryl Compounds	10-15	beta-lactoglobulin	Bos taurus	82-85
18800055-2	2008	We have arrested Env activation at a stage prior to isomerization by alkylating the active thiol in SU and compared the structure of isomerization-arrested Env with that of native Env.	Sulfhydryl Compounds	91-96	melanoma antigen	Mus musculus	17-20
18845687-5	2008	In the present experiments, SAT1 activity increased significantly under conditions of light and oxidative stress in concert with total thiols in wild-type plants.	Sulfhydryl Compounds	135-141	serine acetyltransferase 2;1	Arabidopsis thaliana	28-32
18845687-8	2008	Together with the earlier report that CYP20-3 foldase activity is enhanced by thioredoxin-mediated reduction, our findings suggest that CYP20-3 links photosynthetic electron transport and redox regulation to the folding of SAT1, thereby enabling the cysteine-based thiol biosynthesis pathway to adjust to light and stress conditions.	Sulfhydryl Compounds	265-270	rotamase CYP 4	Arabidopsis thaliana	38-45
18845687-8	2008	Together with the earlier report that CYP20-3 foldase activity is enhanced by thioredoxin-mediated reduction, our findings suggest that CYP20-3 links photosynthetic electron transport and redox regulation to the folding of SAT1, thereby enabling the cysteine-based thiol biosynthesis pathway to adjust to light and stress conditions.	Sulfhydryl Compounds	265-270	thioredoxin H-type 1	Arabidopsis thaliana	78-89
18845687-8	2008	Together with the earlier report that CYP20-3 foldase activity is enhanced by thioredoxin-mediated reduction, our findings suggest that CYP20-3 links photosynthetic electron transport and redox regulation to the folding of SAT1, thereby enabling the cysteine-based thiol biosynthesis pathway to adjust to light and stress conditions.	Sulfhydryl Compounds	265-270	rotamase CYP 4	Arabidopsis thaliana	136-143
18845687-8	2008	Together with the earlier report that CYP20-3 foldase activity is enhanced by thioredoxin-mediated reduction, our findings suggest that CYP20-3 links photosynthetic electron transport and redox regulation to the folding of SAT1, thereby enabling the cysteine-based thiol biosynthesis pathway to adjust to light and stress conditions.	Sulfhydryl Compounds	265-270	serine acetyltransferase 2;1	Arabidopsis thaliana	223-227
18661523-1	2008	Here we report that human nonsmall cell lung carcinomas overexpress macrophage migration inhibitory factor (MIF) and thioredoxin (Trx), 2 oxidoreductases with cytokine function, and contain more abundant nonprotein thiols (glutathione and cysteine) than nonneoplastic lung tissues.	Sulfhydryl Compounds	215-221	macrophage migration inhibitory factor	Homo sapiens	108-111
18803398-5	2008	Near the apex of the groove, the periplasmic side of TMH 6 in both monomers contains a hotspot of change-in-specificity mutations and residues which, when replaced with cysteines in ABCB1, covalently interact with thiol-reactive drug analogues.	Sulfhydryl Compounds	214-219	ATP binding cassette subfamily B member 1	Homo sapiens	182-187
18661523-1	2008	Here we report that human nonsmall cell lung carcinomas overexpress macrophage migration inhibitory factor (MIF) and thioredoxin (Trx), 2 oxidoreductases with cytokine function, and contain more abundant nonprotein thiols (glutathione and cysteine) than nonneoplastic lung tissues.	Sulfhydryl Compounds	215-221	thioredoxin	Homo sapiens	130-133
18838692-2	2008	Many chemical and phytochemical agents, all of which react with thiol groups, induce the phase 2 response through their reactivity with critical cysteine thiols of Keap1.	Sulfhydryl Compounds	64-69	kelch-like ECH-associated protein 1	Mus musculus	164-169
18661523-3	2008	Interestingly, the different clones generate extracellularly reduced nonprotein thiols, in amounts related to the Trx content and inhibited by inhibitors of Trx function.	Sulfhydryl Compounds	80-86	thioredoxin	Homo sapiens	114-117
18661523-3	2008	Interestingly, the different clones generate extracellularly reduced nonprotein thiols, in amounts related to the Trx content and inhibited by inhibitors of Trx function.	Sulfhydryl Compounds	80-86	thioredoxin	Homo sapiens	157-160
18710282-0	2008	Thiol/acrylate-modified PEO-PPO-PEO triblocks used as reactive and thermosensitive copolymers.	Sulfhydryl Compounds	0-5	protoporphyrinogen oxidase	Homo sapiens	28-31
18684987-6	2008	Redox-sensitive thiols are critical for signal transduction (e.g., H-Ras, PTP-1B), transcription factor binding to DNA (e.g., Nrf-2, nuclear factor-kappaB), receptor activation (e.g., alphaIIbbeta3 integrin in platelet activation), and other processes.	Sulfhydryl Compounds	16-22	HRas proto-oncogene, GTPase	Homo sapiens	67-72
18684987-6	2008	Redox-sensitive thiols are critical for signal transduction (e.g., H-Ras, PTP-1B), transcription factor binding to DNA (e.g., Nrf-2, nuclear factor-kappaB), receptor activation (e.g., alphaIIbbeta3 integrin in platelet activation), and other processes.	Sulfhydryl Compounds	16-22	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	74-80
18684987-6	2008	Redox-sensitive thiols are critical for signal transduction (e.g., H-Ras, PTP-1B), transcription factor binding to DNA (e.g., Nrf-2, nuclear factor-kappaB), receptor activation (e.g., alphaIIbbeta3 integrin in platelet activation), and other processes.	Sulfhydryl Compounds	16-22	NFE2 like bZIP transcription factor 2	Homo sapiens	126-131
18662741-2	2008	We show here that the thiol-modifying agent N-ethyl-maleimide abrogates CerK activity in vitro and in a cell based assay, implying that important cysteine residues are accessible in purified as well as endogenous CerK.	Sulfhydryl Compounds	22-27	ceramide kinase	Homo sapiens	72-76
18662741-2	2008	We show here that the thiol-modifying agent N-ethyl-maleimide abrogates CerK activity in vitro and in a cell based assay, implying that important cysteine residues are accessible in purified as well as endogenous CerK.	Sulfhydryl Compounds	22-27	ceramide kinase	Homo sapiens	213-217
18586881-8	2008	TTase(-/-) LECs had significantly lower levels of glutathione (GSH) and protein thiols with extensive elevation of glutathionylated proteins, and they exhibited less resistance to oxidative stress than did TTase(+/+) cells.	Sulfhydryl Compounds	80-86	glutaredoxin	Mus musculus	0-5
19016754-1	2008	Peroxiredoxins (Prdxs) are thiol-specific antioxidant proteins that are highly expressed in human cancer cells.	Sulfhydryl Compounds	27-32	peroxiredoxin 1	Homo sapiens	0-14
18636507-1	2008	Thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- and constitutes a major thiol reducing system.	Sulfhydryl Compounds	58-63	thioredoxin	Homo sapiens	0-11
18636507-1	2008	Thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- and constitutes a major thiol reducing system.	Sulfhydryl Compounds	58-63	thioredoxin	Homo sapiens	13-16
18535615-2	2008	According to several reports, tPA may also have antiangiogenic properties, especially in combination with a free sulfhydryl donor (FSD).	Sulfhydryl Compounds	113-123	plasminogen activator, tissue type	Homo sapiens	30-33
18412143-9	2008	In addition, N-acetyl-L-cystein (NAC), a thiol-containing anti-oxidant, completely blocked As2O3-induced p38 MAPK and JNK activations, mitochondria translocation of Bax, and phosphorylation of Bcl-2.	Sulfhydryl Compounds	41-46	X-linked Kx blood group	Homo sapiens	13-31
18412143-9	2008	In addition, N-acetyl-L-cystein (NAC), a thiol-containing anti-oxidant, completely blocked As2O3-induced p38 MAPK and JNK activations, mitochondria translocation of Bax, and phosphorylation of Bcl-2.	Sulfhydryl Compounds	41-46	X-linked Kx blood group	Homo sapiens	33-36
18799680-6	2008	In cells transfected with tagged PKCepsilon, hydrogen peroxide induced translocation and a reduction in free sulfhydryls of full-length PKCepsilon but not of the deletion mutant lacking the C1A domain.	Sulfhydryl Compounds	109-120	protein kinase C, epsilon	Mus musculus	33-43
18669538-8	2008	This apparent dual effect of trypsin on channel gating and on the recruitment of near-silent channels was confirmed by experiments using the beta518C mutant ENaC which can be converted to a channel with an open probability of nearly one by exposure to a sulfhydryl reagent.	Sulfhydryl Compounds	254-264	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	157-161
18652832-0	2008	Development of a spiral piezoelectric immunosensor based on thiol self-assembled monolayers for the detection of insulin.	Sulfhydryl Compounds	60-65	insulin	Homo sapiens	113-120
18652832-2	2008	Anti-human insulin antibody was first modified with sulfosuccinimidyl 6-[3"-(2-pyridyldithio) propionamido] hexanoate (Sulfo-LC-SPDP) to graft the active sulfhydryl groups into antibody molecules.	Sulfhydryl Compounds	154-164	insulin	Homo sapiens	11-18
18804034-5	2008	These agents used in part a thiol-dependent mechanism to inhibit TGM2, consistent with the activation of TGM2 by reduction of an intramolecular disulfide bond.	Sulfhydryl Compounds	28-33	transglutaminase 2	Homo sapiens	65-69
18550891-5	2008	Cross-linking of intact cells with the thiol-cleavable agent dithiobis(succinimidylpropionate) (DSP), as well as nondenaturing immunoprecipitation, demonstrated an interaction between p97 and intracellular apoB.	Sulfhydryl Compounds	39-44	melanotransferrin	Homo sapiens	184-187
18846282-6	2008	We confirmed the thioredoxin-dependent reduction of a disulfide bond in CHLI2 and thiol-modulation of its ATPase activity.	Sulfhydryl Compounds	82-87	thioredoxin H-type 1	Arabidopsis thaliana	17-28
18556757-0	2008	Probing conformational changes of prestin with thiol-reactive optical switches.	Sulfhydryl Compounds	47-52	solute carrier family 26 member 5	Homo sapiens	34-41
18556757-1	2008	Thiol-reactive optical switch probes were used to examine conformational changes of prestin-based membrane motor.	Sulfhydryl Compounds	0-5	solute carrier family 26 member 5	Homo sapiens	84-91
18799680-6	2008	In cells transfected with tagged PKCepsilon, hydrogen peroxide induced translocation and a reduction in free sulfhydryls of full-length PKCepsilon but not of the deletion mutant lacking the C1A domain.	Sulfhydryl Compounds	109-120	protein kinase C, epsilon	Mus musculus	136-146
18781015-4	2008	The FET-based immunoassay was constructed by combining the 11-FUT modified-FET sensor with the enzyme-linked immunosorbent assay (ELISA), in which the enzyme chemistry of acetylcholinesterase (AChE) was used to generate a thiol compound.	Sulfhydryl Compounds	222-227	acetylcholinesterase (Cartwright blood group)	Homo sapiens	171-191
18683927-2	2008	The reaction of iridium complex is reversible, and the formation of an intermediary Ir-H/thiol complex was detected.	Sulfhydryl Compounds	89-94	C-X-C motif chemokine ligand 12	Homo sapiens	84-88
18638547-1	2008	The mammalian thioredoxin (Trx) system, composed of Trx, Trx reductase (TrxR), and NADPH, is the most important thiol system involved in the redox control of signaling and regulatory proteins in apoptosis and cell proliferation.	Sulfhydryl Compounds	112-117	thioredoxin	Homo sapiens	14-25
18638547-1	2008	The mammalian thioredoxin (Trx) system, composed of Trx, Trx reductase (TrxR), and NADPH, is the most important thiol system involved in the redox control of signaling and regulatory proteins in apoptosis and cell proliferation.	Sulfhydryl Compounds	112-117	thioredoxin	Homo sapiens	27-30
18638547-1	2008	The mammalian thioredoxin (Trx) system, composed of Trx, Trx reductase (TrxR), and NADPH, is the most important thiol system involved in the redox control of signaling and regulatory proteins in apoptosis and cell proliferation.	Sulfhydryl Compounds	112-117	thioredoxin	Homo sapiens	52-55
18638547-1	2008	The mammalian thioredoxin (Trx) system, composed of Trx, Trx reductase (TrxR), and NADPH, is the most important thiol system involved in the redox control of signaling and regulatory proteins in apoptosis and cell proliferation.	Sulfhydryl Compounds	112-117	thioredoxin	Homo sapiens	52-55
18728870-2	2008	Upon electrostatic binding of Cyt-c to Au electrodes coated with self-assembled monolayers (SAMs) of carboxyl-terminated thiols, cyclic voltammetric measurements demonstrate a reversible redox process with a redox potential that is similar to that of Cyt-c in solution, and a non-exponential distance-dependence of the electron transfer rate as observed previously (D. H. Murgida and P. Hildebrandt, Chem.	Sulfhydryl Compounds	121-127	cytochrome c, somatic	Homo sapiens	30-35
18728870-2	2008	Upon electrostatic binding of Cyt-c to Au electrodes coated with self-assembled monolayers (SAMs) of carboxyl-terminated thiols, cyclic voltammetric measurements demonstrate a reversible redox process with a redox potential that is similar to that of Cyt-c in solution, and a non-exponential distance-dependence of the electron transfer rate as observed previously (D. H. Murgida and P. Hildebrandt, Chem.	Sulfhydryl Compounds	121-127	cytochrome c, somatic	Homo sapiens	251-256
18611857-3	2008	Here we investigate complex I thiol modification within oxidatively stressed mammalian mitochondria, containing physiological levels of glutathione and glutaredoxin 2.	Sulfhydryl Compounds	30-35	glutaredoxin 2	Homo sapiens	152-166
18479206-4	2008	In turn, these enzymes are in close redox communication with the thioredoxin and glutathione systems, which are the major controllers of the thiol redox state.	Sulfhydryl Compounds	141-146	thioredoxin	Homo sapiens	65-76
18489898-1	2008	Peroxiredoxin 5 (PRDX5) belongs to the PRDX superfamily of thiol-dependent peroxidases able to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite.	Sulfhydryl Compounds	59-64	peroxiredoxin 5	Homo sapiens	0-15
18489898-1	2008	Peroxiredoxin 5 (PRDX5) belongs to the PRDX superfamily of thiol-dependent peroxidases able to reduce hydrogen peroxide, alkyl hydroperoxides and peroxynitrite.	Sulfhydryl Compounds	59-64	peroxiredoxin 5	Homo sapiens	17-22
18781015-4	2008	The FET-based immunoassay was constructed by combining the 11-FUT modified-FET sensor with the enzyme-linked immunosorbent assay (ELISA), in which the enzyme chemistry of acetylcholinesterase (AChE) was used to generate a thiol compound.	Sulfhydryl Compounds	222-227	acetylcholinesterase (Cartwright blood group)	Homo sapiens	193-197
18792398-7	2008	Increased thiol release following activation requires thioredoxin and is paralleled by increased thioredoxin expression.	Sulfhydryl Compounds	10-15	thioredoxin	Homo sapiens	54-65
18637653-3	2008	Herein, we describe the improvement of the photoaffinity-thiol linker of our SPR imaging platform, which enabled us to determine the binding site of p62 to p38.	Sulfhydryl Compounds	57-62	sepiapterin reductase	Homo sapiens	77-80
18637653-3	2008	Herein, we describe the improvement of the photoaffinity-thiol linker of our SPR imaging platform, which enabled us to determine the binding site of p62 to p38.	Sulfhydryl Compounds	57-62	sequestosome 1	Homo sapiens	149-152
18637653-3	2008	Herein, we describe the improvement of the photoaffinity-thiol linker of our SPR imaging platform, which enabled us to determine the binding site of p62 to p38.	Sulfhydryl Compounds	57-62	mitogen-activated protein kinase 14	Homo sapiens	156-159
18698849-7	2008	The thiol-containing plasma proteins alpha1-antitrypsin and transthyretin were found to be oxidized in addition to albumin, with this treatment resulting in the inactivation of alpha1-antitrypsin.	Sulfhydryl Compounds	4-9	serpin family A member 1	Homo sapiens	37-55
18698849-7	2008	The thiol-containing plasma proteins alpha1-antitrypsin and transthyretin were found to be oxidized in addition to albumin, with this treatment resulting in the inactivation of alpha1-antitrypsin.	Sulfhydryl Compounds	4-9	serpin family A member 1	Homo sapiens	177-195
18698849-8	2008	A similar selectivity of reaction and extent of thiol oxidation were also observed with myeloperoxidase in the presence of hydrogen peroxide and chloride ions.	Sulfhydryl Compounds	48-53	myeloperoxidase	Homo sapiens	88-103
18792398-7	2008	Increased thiol release following activation requires thioredoxin and is paralleled by increased thioredoxin expression.	Sulfhydryl Compounds	10-15	thioredoxin	Homo sapiens	97-108
18676023-9	2008	Thus, cysteine reactive and thiol antioxidant compounds prevented the loss of STAT6 induced by TPCK.	Sulfhydryl Compounds	28-33	signal transducer and activator of transcription 6	Homo sapiens	78-83
18664402-1	2008	A family of cell surface and growth-related proteins, designated ECTO-NOX proteins, carry out both copper-dependent NADH and hydroquinone oxidation and protein disulfide-thiol interchange.	Sulfhydryl Compounds	170-175	tripartite motif containing 33	Homo sapiens	65-69
18676023-10	2008	The reactivity of thiol groups on STAT6 was moreover demonstrated with biotinylated sulfhydryl-reactive compounds.	Sulfhydryl Compounds	18-23	signal transducer and activator of transcription 6	Homo sapiens	34-39
18721756-5	2008	These data conclusively demonstrate a sulfhydryl-based mechanism for NAM inhibition of hMGL in which Cys(249) is of paramount importance.	Sulfhydryl Compounds	38-48	monoglyceride lipase	Homo sapiens	87-91
19727320-0	2008	Thiol-functionalized shell crosslinked knedel-like (SCK) nanoparticles: A versatile entry for their conjugation with biomacromolecules.	Sulfhydryl Compounds	0-5	SHC adaptor protein 2	Homo sapiens	21-50
19727320-0	2008	Thiol-functionalized shell crosslinked knedel-like (SCK) nanoparticles: A versatile entry for their conjugation with biomacromolecules.	Sulfhydryl Compounds	0-5	SHC adaptor protein 2	Homo sapiens	52-55
19727320-1	2008	Shell crosslinked knedel-like (SCK) nanoparticles were prepared having thiol-terminated poly(ethylene glycol) (PEG) chains extending throughout their shell layers and were then conjugated with bovine serum albumin (BSA) as a model biomacromolecule.	Sulfhydryl Compounds	71-76	SHC adaptor protein 2	Homo sapiens	0-29
19727320-1	2008	Shell crosslinked knedel-like (SCK) nanoparticles were prepared having thiol-terminated poly(ethylene glycol) (PEG) chains extending throughout their shell layers and were then conjugated with bovine serum albumin (BSA) as a model biomacromolecule.	Sulfhydryl Compounds	71-76	SHC adaptor protein 2	Homo sapiens	31-34
18695917-8	2008	In addition, N-acetyl-L-cysteine (NAC), a thiol-containing anti-oxidant, completely blocked p38 MAPK and JNK activations, Bax relocalization and Bcl-2 phosphorylation.	Sulfhydryl Compounds	42-47	X-linked Kx blood group	Homo sapiens	34-37
18544535-5	2008	Similar findings were obtained when the TNFR1- and TNFR2-transfected cells were pretreated with a cell-impermeable oxidase, DsbA, that catalyzes disulfide bond formation between thiol groups on cysteine residues.	Sulfhydryl Compounds	178-183	TNF receptor superfamily member 1A	Homo sapiens	40-45
18544535-5	2008	Similar findings were obtained when the TNFR1- and TNFR2-transfected cells were pretreated with a cell-impermeable oxidase, DsbA, that catalyzes disulfide bond formation between thiol groups on cysteine residues.	Sulfhydryl Compounds	178-183	TNF receptor superfamily member 1B	Homo sapiens	51-56
18602640-3	2008	Upon reduction, circular dichroism confirms it spontaneously anneals with its internally complementary sequence to form the hairpin structure: 5"-HS-GCAGATTGCGCAATCTGC 3"-HS-CGTCTAACGCGTTAGACG The specific GFP-C/EBP protein-DNA complex, formed in solution at nM concentrations, could then be recovered (trapped) via thiol-disulfide exchange with a disulfide thiopropyl-Sepharose and eluted with dithiothreitol.	Sulfhydryl Compounds	316-321	EBP cholestenol delta-isomerase	Homo sapiens	212-215
18656957-3	2008	The human NTPDase 2 activity is inactivated by membrane perturbation that disrupts interaction of the transmembrane domains and is inhibited by p-chloromercuriphenylsulfonate (pCMPS), a sulfhydryl reagent.	Sulfhydryl Compounds	186-196	ectonucleoside triphosphate diphosphohydrolase 2	Homo sapiens	10-19
18503776-1	2008	Peroxiredoxins (PRDXs) are a superfamily of thiol-dependent peroxidases found in all phyla.	Sulfhydryl Compounds	44-49	peroxiredoxin 6	Homo sapiens	0-14
18549408-8	2008	It is concluded that on synthetic medium, Cys-3MH enters the cell through at least one identified transporter, GAP1p, whose activity is limiting the release of volatile thiols.	Sulfhydryl Compounds	169-175	amino acid permease GAP1	Saccharomyces cerevisiae S288C	111-116
18573614-6	2008	Profoundly, pretreatment with thiol-containing compounds NAC or GSH, but not vitamin E, blocked GSH depletion, 38 MAPK activation and MKP-1 expression by cadmium.	Sulfhydryl Compounds	30-35	dual specificity phosphatase 1	Rattus norvegicus	134-139
18616222-2	2008	Installation of terminal functional groups (amine, thiol, or alkyne) onto the sn-2 chain provides reactive sites for bio-orthogonal conjugation of cargo with suitably protected PS derivatives.	Sulfhydryl Compounds	51-56	solute carrier family 38 member 5	Homo sapiens	78-82
18544525-2	2008	The active site of reduced Trx comprises Cys(32)-Gly-Pro-Cys(35) thiols that catalyze target disulfide reduction, generating a disulfide.	Sulfhydryl Compounds	65-71	thioredoxin	Homo sapiens	27-30
18544525-13	2008	The reversible inhibition of human Trx1 activity by H(2)O(2) and NO donors is suggested to act in cell signaling via temporal control of reduction for the transmission of oxidative and/or nitrosative signals in thiol redox control.	Sulfhydryl Compounds	211-216	thioredoxin	Homo sapiens	35-39
18627198-2	2008	In this study, we examined the labeling of annexin V-128, a mutated form of annexin V that has a single cysteine residue at the NH 2 terminus, with the thiol-selective reagent (18)F-labeling agent N-[4-[(4-[(18)F]fluorobenzylidene)aminooxy]butyl]maleimide ([(18)F]FBABM).	Sulfhydryl Compounds	152-157	annexin A5	Homo sapiens	43-52
18627198-10	2008	Conjugation of [(18)F]FBABM with the thiol-containing annexin V-128 gave [(18)F]FAN-128 in 37 +/- 9% yield (n = 4, decay corrected).	Sulfhydryl Compounds	37-42	annexin A5	Homo sapiens	54-63
18397814-4	2008	All samples showed distinct peaks for C 1s, O 1s, N 1s, P 2p and S 2p as expected for a thiol-linked DNA.	Sulfhydryl Compounds	88-93	complement C1s	Homo sapiens	38-42
18397814-4	2008	All samples showed distinct peaks for C 1s, O 1s, N 1s, P 2p and S 2p as expected for a thiol-linked DNA.	Sulfhydryl Compounds	88-93	proteasome 26S subunit ubiquitin receptor, non-ATPase 2	Homo sapiens	65-69
17922126-13	2008	Treatment with a non-thiol antioxidant agent, catalase, completely abrogated H(2)O(2)-induced JNK and ERK phosphorylation, but a thiol antioxidant, L: -cystein, had no effect on phosphorylation of them.	Sulfhydryl Compounds	129-134	catalase	Homo sapiens	46-54
18597470-6	2008	The results show that high surface coverage SAMs with low surface-oxide content can be achieved for thin, evaporated Ni and Co films using our electroreduction process with thiols.	Sulfhydryl Compounds	173-179	methionine adenosyltransferase 1A	Homo sapiens	44-48
18621727-0	2008	Molecular basis for the thiol sensitivity of insulin-degrading enzyme.	Sulfhydryl Compounds	24-29	insulin degrading enzyme	Homo sapiens	45-69
18621727-3	2008	However, despite prior investigation, the molecular basis underlying the sensitivity of IDE to thiol-alkylating agents has not been elucidated.	Sulfhydryl Compounds	95-100	insulin degrading enzyme	Homo sapiens	88-91
18535259-5	2008	The induction of GCLM and NQO1 was attenuated by reduction of electrophilic groups with sodium borohydrate, as well as treatment with thiol antioxidant N-acetylcysteine, suggesting that the thiol reactivity of oxPAPC is largely mediating its effect on Nrf2-responsive genes.	Sulfhydryl Compounds	134-139	glutamate-cysteine ligase, modifier subunit	Mus musculus	17-21
18535259-5	2008	The induction of GCLM and NQO1 was attenuated by reduction of electrophilic groups with sodium borohydrate, as well as treatment with thiol antioxidant N-acetylcysteine, suggesting that the thiol reactivity of oxPAPC is largely mediating its effect on Nrf2-responsive genes.	Sulfhydryl Compounds	134-139	NAD(P)H dehydrogenase, quinone 1	Mus musculus	26-30
18535259-5	2008	The induction of GCLM and NQO1 was attenuated by reduction of electrophilic groups with sodium borohydrate, as well as treatment with thiol antioxidant N-acetylcysteine, suggesting that the thiol reactivity of oxPAPC is largely mediating its effect on Nrf2-responsive genes.	Sulfhydryl Compounds	190-195	glutamate-cysteine ligase, modifier subunit	Mus musculus	17-21
18535259-5	2008	The induction of GCLM and NQO1 was attenuated by reduction of electrophilic groups with sodium borohydrate, as well as treatment with thiol antioxidant N-acetylcysteine, suggesting that the thiol reactivity of oxPAPC is largely mediating its effect on Nrf2-responsive genes.	Sulfhydryl Compounds	190-195	NAD(P)H dehydrogenase, quinone 1	Mus musculus	26-30
18535259-5	2008	The induction of GCLM and NQO1 was attenuated by reduction of electrophilic groups with sodium borohydrate, as well as treatment with thiol antioxidant N-acetylcysteine, suggesting that the thiol reactivity of oxPAPC is largely mediating its effect on Nrf2-responsive genes.	Sulfhydryl Compounds	190-195	nuclear factor, erythroid derived 2, like 2	Mus musculus	252-256
18524580-1	2008	A novel cys-annexin A5 with a single cysteine-residue at its concave side has been developed by site-directed mutagenesis to allow conjugation through thiol-chemistry without affecting its apoptotic cell binding properties and was derivatized with HYNIC in a 1:1 stoichiometry.	Sulfhydryl Compounds	151-156	annexin A5	Mus musculus	12-22
18387321-5	2008	Human erythrocyte Prx2 is a peroxiredoxin with thiol-specific antioxidant activity.	Sulfhydryl Compounds	47-52	peroxiredoxin 2	Homo sapiens	18-22
18515280-7	2008	These results indicate that alk(en)yl trisulfide react with sulfhydryl groups in cysteine residues of cellular proteins such as microtubule proteins.	Sulfhydryl Compounds	60-70	ALK receptor tyrosine kinase	Homo sapiens	28-31
18570440-5	2008	A nearby arginine residue (R48) participates in a guanidinium stacking interaction with R28 from the other monomer in the DJ-1 dimer and elevates the p K a of C106 by binding an anion that electrostatically suppresses thiol ionization.	Sulfhydryl Compounds	218-223	Parkinsonism associated deglycase	Homo sapiens	122-126
17922126-15	2008	But ERK phosphorylation was not inhibited by catalase and was abrogated completely by the thiol antioxidant.	Sulfhydryl Compounds	90-95	mitogen-activated protein kinase 1	Homo sapiens	4-7
18407833-0	2008	Reactive oxygen species generated by thiol-modifying phenylarsine oxide stimulate the expression of protein L-isoaspartyl methyltransferase.	Sulfhydryl Compounds	37-42	protein-L-isoaspartate (D-aspartate) O-methyltransferase	Homo sapiens	100-139
18614421-1	2008	This study has been initiated to determine whether captopril, an angiotensin-converting enzyme (ACE) inhibitor containing sulfhydryl (-SH) group can protect against cisplatin-induced nephrotoxicity in rats.	Sulfhydryl Compounds	122-132	angiotensin I converting enzyme	Rattus norvegicus	65-94
18614421-1	2008	This study has been initiated to determine whether captopril, an angiotensin-converting enzyme (ACE) inhibitor containing sulfhydryl (-SH) group can protect against cisplatin-induced nephrotoxicity in rats.	Sulfhydryl Compounds	122-132	angiotensin I converting enzyme	Rattus norvegicus	96-99
18552768-1	2008	ERp44 mediates thiol-dependent retention in the early secretory pathway, forming mixed disulphides with substrate proteins through its conserved CRFS motif.	Sulfhydryl Compounds	15-20	endoplasmic reticulum protein 44	Homo sapiens	0-5
18433456-4	2008	The presence of thiols in ULVWF and plasma VWF multimers was determined by maleimide-PEO(2)-Biotin labeling and thiol-chromatography.	Sulfhydryl Compounds	16-22	von Willebrand factor	Homo sapiens	28-31
18433456-4	2008	The presence of thiols in ULVWF and plasma VWF multimers was determined by maleimide-PEO(2)-Biotin labeling and thiol-chromatography.	Sulfhydryl Compounds	16-21	von Willebrand factor	Homo sapiens	28-31
18433456-7	2008	The formation and propagation of ULVWF strings were dose-dependently reduced by blocking thiols on VWF with NEM, indicating that ULVWF strings are formed by the covalent association of perfused VWF to ULVWF anchored to endothelial cells.	Sulfhydryl Compounds	89-95	von Willebrand factor	Homo sapiens	35-38
18433456-7	2008	The formation and propagation of ULVWF strings were dose-dependently reduced by blocking thiols on VWF with NEM, indicating that ULVWF strings are formed by the covalent association of perfused VWF to ULVWF anchored to endothelial cells.	Sulfhydryl Compounds	89-95	von Willebrand factor	Homo sapiens	99-102
18433456-8	2008	The association is made possible by the presence of free thiols in VWF multimers and by the ability of (UL) VWF to covalently re-multimerize.	Sulfhydryl Compounds	57-63	von Willebrand factor	Homo sapiens	67-70
18551038-9	2008	MTHFR-Tg mice were generated and confirmed to have increased levels of MTHFR with altered distributions of folate and thiols in a tissue-specific manner.	Sulfhydryl Compounds	118-124	methylenetetrahydrofolate reductase	Mus musculus	0-5
18505275-10	2008	Furthermore, we prepared a selenomethionine form of an MRP and found that selenomethionine selenoxide residues can be efficiently reduced nonenzymatically by glutathione and other thiol compounds.	Sulfhydryl Compounds	180-185	MARCKS like 1	Homo sapiens	55-58
18442981-9	2008	Taken together, our results demonstrate that the TA inhibits the activity of Hsp90-Hsp70 chaperone complex, at least in part, by a direct thiol oxidation, which in turn leads to the destabilization and depletion of Hsp90 client proteins and thus causes cell cycle arrest and apoptosis in MDA-MB-231 cells.	Sulfhydryl Compounds	138-143	heat shock protein 90 alpha family class A member 1	Homo sapiens	77-82
18442981-9	2008	Taken together, our results demonstrate that the TA inhibits the activity of Hsp90-Hsp70 chaperone complex, at least in part, by a direct thiol oxidation, which in turn leads to the destabilization and depletion of Hsp90 client proteins and thus causes cell cycle arrest and apoptosis in MDA-MB-231 cells.	Sulfhydryl Compounds	138-143	heat shock protein family A (Hsp70) member 4	Homo sapiens	83-88
18442981-9	2008	Taken together, our results demonstrate that the TA inhibits the activity of Hsp90-Hsp70 chaperone complex, at least in part, by a direct thiol oxidation, which in turn leads to the destabilization and depletion of Hsp90 client proteins and thus causes cell cycle arrest and apoptosis in MDA-MB-231 cells.	Sulfhydryl Compounds	138-143	heat shock protein 90 alpha family class A member 1	Homo sapiens	215-220
18560520-6	2008	The thiol groups of voltage dependent anion channel (VDAC), an outer membrane protein in mitochondria but not adenosine nucleotide translocase (ANT), an inner membrane protein, are oxidized when Grx1 is downregulated.	Sulfhydryl Compounds	4-9	glutaredoxin	Homo sapiens	195-199
18445702-5	2008	The expression response to elevated oxidative stress in vivo does not involve an upregulation of classic antioxidant genes, although long-term oxidative stress in Sod1(-/-) mice leads to a significant upregulation of thiol antioxidants (e.g., Mt1, Srxn1, Gclc, Txnrd1), which appears to be mediated by the redox-sensitive transcription factor Nrf2.	Sulfhydryl Compounds	217-222	superoxide dismutase 1, soluble	Mus musculus	163-167
18555775-1	2008	Thioredoxin 1 (Trx1) facilitates the reduction of signaling molecules and transcription factors by cysteine thiol-disulfide exchange, thereby regulating cell growth and death.	Sulfhydryl Compounds	108-113	thioredoxin	Homo sapiens	0-13
18555775-1	2008	Thioredoxin 1 (Trx1) facilitates the reduction of signaling molecules and transcription factors by cysteine thiol-disulfide exchange, thereby regulating cell growth and death.	Sulfhydryl Compounds	108-113	thioredoxin	Homo sapiens	15-19
18560520-2	2008	Glutaredoxin 1 (Grx1), a cytosolic thiol disulfide oxido-reductase, reduces glutathionylated proteins to protein thiols and helps maintain redox status of proteins during oxidative stress.	Sulfhydryl Compounds	35-40	glutaredoxin	Homo sapiens	0-14
18560520-2	2008	Glutaredoxin 1 (Grx1), a cytosolic thiol disulfide oxido-reductase, reduces glutathionylated proteins to protein thiols and helps maintain redox status of proteins during oxidative stress.	Sulfhydryl Compounds	35-40	glutaredoxin	Homo sapiens	16-20
18560520-2	2008	Glutaredoxin 1 (Grx1), a cytosolic thiol disulfide oxido-reductase, reduces glutathionylated proteins to protein thiols and helps maintain redox status of proteins during oxidative stress.	Sulfhydryl Compounds	113-119	glutaredoxin	Homo sapiens	0-14
18560520-2	2008	Glutaredoxin 1 (Grx1), a cytosolic thiol disulfide oxido-reductase, reduces glutathionylated proteins to protein thiols and helps maintain redox status of proteins during oxidative stress.	Sulfhydryl Compounds	113-119	glutaredoxin	Homo sapiens	16-20
18560520-5	2008	Downregulation of Grx1 by shRNA results in loss of mitochondrial membrane potential (MMP), which is prevented by the thiol antioxidant, alpha-lipoic acid, or by cyclosporine A, an inhibitor of mitochondrial permeability transition.	Sulfhydryl Compounds	117-122	glutaredoxin	Homo sapiens	18-22
18465840-2	2008	In the mutant, a free thiol group of wild-type beta-lg at Cys121 was removed and two beta-lg molecules were linked by a disulfide bridge through Cys34 created at the dimer"s interface.	Sulfhydryl Compounds	22-27	beta-lactoglobulin	Bos taurus	47-54
18481886-7	2008	Chemoselecetive conjugation of [(18)F]FDG-MHO to thiol groups was investigated by the reaction with the tripeptide glutathione (GSH) and the single cysteine containing protein annexin A5 (anxA5).	Sulfhydryl Compounds	49-54	annexin A5	Mus musculus	176-186
18373437-8	2008	We recently provided evidence that PDI exerts functionally relevant regulation of NADPH oxidase activity in vascular smooth muscle and endothelial cells, in a thiol redox-dependent manner.	Sulfhydryl Compounds	159-164	prolyl 4-hydroxylase subunit beta	Homo sapiens	35-38
18481886-7	2008	Chemoselecetive conjugation of [(18)F]FDG-MHO to thiol groups was investigated by the reaction with the tripeptide glutathione (GSH) and the single cysteine containing protein annexin A5 (anxA5).	Sulfhydryl Compounds	49-54	annexin A5	Mus musculus	188-193
18447393-2	2008	In the current study, we showed by mass spectrometry that a thiol alkylating agent, N-ethylmaleimide (NEM), alkylated a single cysteine residue in the active center of Trx2.	Sulfhydryl Compounds	60-65	thioredoxin 2	Homo sapiens	168-172
18447393-6	2008	Our data suggest that the alkylation of the essential thiol(s) of Trx2 has profound impact on the mitochondrial redox circuitry and that such effects are distinct from the responses to agents causing reversible disulfide bond formation between the vicinal dithiols in the active center.	Sulfhydryl Compounds	54-59	thioredoxin 2	Homo sapiens	66-70
18359958-3	2008	To determine the functional importance of such a pathway, confocal microscopy was used to characterize the internalization of a fully functional apoA-I cysteine mutant containing a thiol-reactive fluorescent probe in cultured macrophages.	Sulfhydryl Compounds	181-186	apolipoprotein A1	Homo sapiens	145-151
18466086-3	2008	The MnSOD 60C &gt; T polymorphism within exon 3 changes leucine to phenylalanine, rendering the protein sensitive to redox regulation by intracellular thiols.	Sulfhydryl Compounds	151-157	superoxide dismutase 2	Homo sapiens	4-9
18357467-3	2008	A screen for mutants resistant to the thiol-specific oxidant dipyridyl disulfide (DPS) yielded tao3-516, which is impaired in the function of the RAM signaling network protein Tao3/Pag1p.	Sulfhydryl Compounds	38-43	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	181-186
18400945-7	2008	Our observations suggest that Grx6 and Grx7 do not play a general role in the oxidative folding of proteins in the early secretory pathway but rather counteract the oxidation of specific thiol groups in substrate proteins.	Sulfhydryl Compounds	187-192	glutathione-disulfide reductase GRX6	Saccharomyces cerevisiae S288C	30-34
18400945-7	2008	Our observations suggest that Grx6 and Grx7 do not play a general role in the oxidative folding of proteins in the early secretory pathway but rather counteract the oxidation of specific thiol groups in substrate proteins.	Sulfhydryl Compounds	187-192	glutathione-disulfide reductase GRX7	Saccharomyces cerevisiae S288C	39-43
18393506-0	2008	Oxidation of porcine Myosin by hypervalent myoglobin: the role of thiol groups.	Sulfhydryl Compounds	66-71	myosin heavy chain 14	Homo sapiens	21-27
18520954-7	2008	ACE inhibitors possessing a sulfhydryl moiety appear to have additional benefits in increasing nitric-oxide release and improving vascular endothelial function.	Sulfhydryl Compounds	28-38	angiotensin I converting enzyme	Homo sapiens	0-3
18393506-3	2008	The target for oxidative modification of myosin was studied by thiol blocking by N-acetylmaleimide (NEM) and by determining oxidative modification of myosin thiols.	Sulfhydryl Compounds	63-68	myosin heavy chain 14	Homo sapiens	41-47
18393506-3	2008	The target for oxidative modification of myosin was studied by thiol blocking by N-acetylmaleimide (NEM) and by determining oxidative modification of myosin thiols.	Sulfhydryl Compounds	157-163	myosin heavy chain 14	Homo sapiens	41-47
18419134-3	2008	Thiol specific reagents showed significant redox cycling between the reactive thiols and the TNB anion, and using NEM, four of the six reactive thiols are critical to the functionality of hBCATc.	Sulfhydryl Compounds	78-84	branched chain amino acid transaminase 1	Homo sapiens	188-194
18393506-3	2008	The target for oxidative modification of myosin was studied by thiol blocking by N-acetylmaleimide (NEM) and by determining oxidative modification of myosin thiols.	Sulfhydryl Compounds	157-163	myosin heavy chain 14	Homo sapiens	150-156
18419134-3	2008	Thiol specific reagents showed significant redox cycling between the reactive thiols and the TNB anion, and using NEM, four of the six reactive thiols are critical to the functionality of hBCATc.	Sulfhydryl Compounds	144-150	branched chain amino acid transaminase 1	Homo sapiens	188-194
18419134-3	2008	Thiol specific reagents showed significant redox cycling between the reactive thiols and the TNB anion, and using NEM, four of the six reactive thiols are critical to the functionality of hBCATc.	Sulfhydryl Compounds	0-5	branched chain amino acid transaminase 1	Homo sapiens	188-194
18393506-6	2008	Myosin thiols are suggested to be the main target for oxidative modification, as NEM-treated myosin did not form radicals in the presence of hypervalent myoglobin.	Sulfhydryl Compounds	7-13	myosin heavy chain 14	Homo sapiens	0-6
18393506-6	2008	Myosin thiols are suggested to be the main target for oxidative modification, as NEM-treated myosin did not form radicals in the presence of hypervalent myoglobin.	Sulfhydryl Compounds	7-13	myosin heavy chain 14	Homo sapiens	93-99
18419134-5	2008	However, only the thiols of the CXXC motif (C335 and C338) were directly involved in the reversible redox regulation of hBCATc through oxidation (with a loss of 40-45% BCAT activity on air oxidation alone).	Sulfhydryl Compounds	18-24	branched chain amino acid transaminase 1	Homo sapiens	120-126
18393506-7	2008	A significant decrease in thiol content was already demonstrated 25 s after initiation of oxidation of myosin.	Sulfhydryl Compounds	26-31	myosin heavy chain 14	Homo sapiens	103-109
18419134-8	2008	S-thiolation experiments of hBCATc exposed to GSH provided evidence for significant recycling between GSH and the thiols of hBCATc, which implied that under reducing conditions GSH was operating as a thiol donor with minimal S-glutathionylation.	Sulfhydryl Compounds	114-120	branched chain amino acid transaminase 1	Homo sapiens	28-34
18393506-9	2008	This demonstrates that thiols are important for radical formation and cross-linking of myosin during oxidation with hypervalent myoglobin at the pH of meat products.	Sulfhydryl Compounds	23-29	myosin heavy chain 14	Homo sapiens	87-93
18419134-8	2008	S-thiolation experiments of hBCATc exposed to GSH provided evidence for significant recycling between GSH and the thiols of hBCATc, which implied that under reducing conditions GSH was operating as a thiol donor with minimal S-glutathionylation.	Sulfhydryl Compounds	114-120	branched chain amino acid transaminase 1	Homo sapiens	124-130
18419134-8	2008	S-thiolation experiments of hBCATc exposed to GSH provided evidence for significant recycling between GSH and the thiols of hBCATc, which implied that under reducing conditions GSH was operating as a thiol donor with minimal S-glutathionylation.	Sulfhydryl Compounds	2-7	branched chain amino acid transaminase 1	Homo sapiens	28-34
18393558-4	2008	Ellipsometric measurements show that the amount of the MCH groups on surfaces increases with increasing mol % of the MCH thiols in the loading solution up to about 80 mol %.	Sulfhydryl Compounds	121-127	pro-melanin concentrating hormone	Homo sapiens	55-58
18419134-8	2008	S-thiolation experiments of hBCATc exposed to GSH provided evidence for significant recycling between GSH and the thiols of hBCATc, which implied that under reducing conditions GSH was operating as a thiol donor with minimal S-glutathionylation.	Sulfhydryl Compounds	2-7	branched chain amino acid transaminase 1	Homo sapiens	124-130
18419134-13	2008	Thus, our data provides strong evidence that the reactive thiol groups, in particular the thiols of the CXXC motif, play an integral role in redox regulation and that hBCATc has redox mediated associations with several neuronal proteins involved in G-protein cell signaling, indicating a novel role for hBCATc in cellular redox control.	Sulfhydryl Compounds	58-63	branched chain amino acid transaminase 1	Homo sapiens	167-173
18419134-13	2008	Thus, our data provides strong evidence that the reactive thiol groups, in particular the thiols of the CXXC motif, play an integral role in redox regulation and that hBCATc has redox mediated associations with several neuronal proteins involved in G-protein cell signaling, indicating a novel role for hBCATc in cellular redox control.	Sulfhydryl Compounds	90-96	branched chain amino acid transaminase 1	Homo sapiens	167-173
18393558-4	2008	Ellipsometric measurements show that the amount of the MCH groups on surfaces increases with increasing mol % of the MCH thiols in the loading solution up to about 80 mol %.	Sulfhydryl Compounds	121-127	pro-melanin concentrating hormone	Homo sapiens	117-120
18439041-0	2008	Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine.	Sulfhydryl Compounds	133-138	superoxide dismutase 2	Homo sapiens	15-45
18321861-5	2008	Fully reduced human Trx1 bound mercury and lost all five free thiols and activity after incubation with HgCl(2) or MeHg, but only HgCl(2) generated dimers.	Sulfhydryl Compounds	62-68	thioredoxin	Homo sapiens	20-24
18321861-9	2008	Human Grx1 showed similar reactivity as Trx1 with both mercurial compounds, with the loss of all free thiols and Grx dimerization in the presence of HgCl(2), but no inhibition of Grx activity was observed in lysates of HeLa cells exposed to mercury.	Sulfhydryl Compounds	102-108	glutaredoxin	Homo sapiens	6-10
18321861-9	2008	Human Grx1 showed similar reactivity as Trx1 with both mercurial compounds, with the loss of all free thiols and Grx dimerization in the presence of HgCl(2), but no inhibition of Grx activity was observed in lysates of HeLa cells exposed to mercury.	Sulfhydryl Compounds	102-108	glutaredoxin	Homo sapiens	6-9
18035847-11	2008	The second enhancement is the direct use of a Cys(Mob) or Sec(Mob) derivative as the nucleophilic partner instead of utilizing a naked sulfhydryl or selenol.	Sulfhydryl Compounds	135-145	sphingomyelin synthase 1	Homo sapiens	62-65
18434149-1	2008	To prepare thiol-reactive ifenprodil derivatives designed as potential probes for cysteine-substituted NR2B containing NMDA receptors, electrophilic centers were introduced in different areas of the ifenprodil structure.	Sulfhydryl Compounds	11-16	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	103-107
18357452-2	2008	A Saccharomyces cerevisiae sit4-110 mutant is here described, which was isolated as resistant to the thiol-specific oxidant dipyridyl disulfide (DPS) and which contains a single-residue substitution in the SIT4 gene.	Sulfhydryl Compounds	101-106	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	27-31
18357452-2	2008	A Saccharomyces cerevisiae sit4-110 mutant is here described, which was isolated as resistant to the thiol-specific oxidant dipyridyl disulfide (DPS) and which contains a single-residue substitution in the SIT4 gene.	Sulfhydryl Compounds	101-106	type 2A-related serine/threonine-protein phosphatase SIT4	Saccharomyces cerevisiae S288C	206-210
18458837-5	2008	Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively.	Sulfhydryl Compounds	81-87	kelch like ECH associated protein 1	Homo sapiens	119-124
18458837-5	2008	Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively.	Sulfhydryl Compounds	81-87	kelch like ECH associated protein 1	Homo sapiens	126-161
18458837-5	2008	Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively.	Sulfhydryl Compounds	81-87	NFE2 like bZIP transcription factor 2	Homo sapiens	210-214
18458837-5	2008	Isothiocyanates appear to alter gene expression through modification of critical thiols in regulatory proteins such as Keap1 (Kelch-like ECH-associated protein 1) or IKK (IkappaB kinase), causing activation of Nrf2 and inactivation of NF-kappaB, respectively.	Sulfhydryl Compounds	81-87	nuclear factor kappa B subunit 1	Homo sapiens	235-244
18484410-5	2008	Loss of enzyme activity was observed and the inactivation of IDPm was reversed by thiols.	Sulfhydryl Compounds	82-88	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	61-65
18357440-1	2008	Using transfected HEK293 cells that express the human (h) noradrenaline transporter (hNAT), we show differential inhibitory effects of the thiol reagent N-ethylmaleimide (NEM) on [(3)H]NA uptake and [(3)H]nisoxetine binding.	Sulfhydryl Compounds	139-144	solute carrier family 6 member 2	Homo sapiens	58-83
18456507-5	2008	N-acetylcysteine (NAC), a thiol reducing agent, but not reactive oxygen species scavengers, prevented 15d-PGJ(2)-induced COX-2 up-regulation.	Sulfhydryl Compounds	26-31	synuclein alpha	Homo sapiens	18-21
18456507-6	2008	Depletion of GSH by buthionine sulfoximine, which diminishes thiol antioxidant activity, cooperated with 15d-PGJ(2) to accumulate COX-2.	Sulfhydryl Compounds	61-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	130-135
18456507-7	2008	Therefore, 15d-PGJ(2) up-regulated COX-2 through a thiol antioxidant-sensitive mechanism.	Sulfhydryl Compounds	51-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
18546891-3	2008	Using LC-ESITOFMS and FTMS analysis, we determined that the major structural change in oxidized HSA in healthy human plasma is a disulfide-bonded cysteine at the thiol of Cys34 of reduced HSA.	Sulfhydryl Compounds	162-167	albumin	Homo sapiens	96-99
18439041-0	2008	Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine.	Sulfhydryl Compounds	133-138	superoxide dismutase 2	Homo sapiens	47-51
18068118-0	2008	Thiol reactivity as a sensor of rotation of the converter in myosin.	Sulfhydryl Compounds	0-5	myosin heavy chain 14	Homo sapiens	61-67
18393449-9	2008	C452, of the proximal disulfide, is shown to be the charge-transfer donor to the flavin ring of QSOX, and its partner, C449, is expected to be the interchange thiol, forming a mixed disulfide with C70 in the thioredoxin domain.	Sulfhydryl Compounds	159-164	quiescin sulfhydryl oxidase 1	Homo sapiens	96-100
18068118-1	2008	Smooth muscle myosin has two reactive thiols located near the C-terminal region of its motor domain, the "converter", which rotates by approximately 70 degrees upon the transition from the "nucleotide-free" state to the "pre-power stroke" state.	Sulfhydryl Compounds	38-44	myosin heavy chain 14	Homo sapiens	14-20
18068118-2	2008	The incorporation rates of a thiol reagent, 5-(((2-iodoacetyl)amino)ethyl)aminonaphthalene-1-sulfonic acid (IAEDANS), into these thiols were greatly altered by adding ATP or changing the myosin conformation.	Sulfhydryl Compounds	29-34	myosin heavy chain 14	Homo sapiens	187-193
18068118-2	2008	The incorporation rates of a thiol reagent, 5-(((2-iodoacetyl)amino)ethyl)aminonaphthalene-1-sulfonic acid (IAEDANS), into these thiols were greatly altered by adding ATP or changing the myosin conformation.	Sulfhydryl Compounds	129-135	myosin heavy chain 14	Homo sapiens	187-193
18068118-3	2008	Comparisons of the myosin structures in the pre-power stroke state and the nucleotide-free state explained why the reactivity of both thiols is especially sensitive to a conformational change around the converter, and thus can be used as a sensor of the rotation of the converter.	Sulfhydryl Compounds	134-140	myosin heavy chain 14	Homo sapiens	19-25
18238778-5	2008	Both glycerol 3-phosphate and fatty acyl-CoA increased the GPAT activity, and the activity was sensitive to N-ethylmaleimide, a sulfhydryl-modifying reagent.	Sulfhydryl Compounds	128-138	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	59-63
18237276-5	2008	Reversible inactivation of purified MTAP by hydrogen peroxide results from a reduction of V(max) and involves the specific oxidation of Cys(136) and Cys(223) thiols to sulfenic acid that may be further stabilized to sulfenyl amide intermediates.	Sulfhydryl Compounds	158-164	methylthioadenosine phosphorylase	Homo sapiens	36-40
18328613-4	2008	The thioredoxin (Trx) system has a key role in the maintenance of cellular thiol redox balance and is essential for cell survival.	Sulfhydryl Compounds	75-80	thioredoxin	Homo sapiens	4-15
18328613-4	2008	The thioredoxin (Trx) system has a key role in the maintenance of cellular thiol redox balance and is essential for cell survival.	Sulfhydryl Compounds	75-80	thioredoxin	Homo sapiens	17-20
18413607-5	2008	Glutathione and thioredoxins can reduce and inactivate p66(Shc), resulting in a thiol-based redox sensor system that initiates apoptosis once cellular protection systems cannot cope anymore with cellular stress.	Sulfhydryl Compounds	80-85	DNA polymerase delta 3, accessory subunit	Homo sapiens	55-58
18413607-5	2008	Glutathione and thioredoxins can reduce and inactivate p66(Shc), resulting in a thiol-based redox sensor system that initiates apoptosis once cellular protection systems cannot cope anymore with cellular stress.	Sulfhydryl Compounds	80-85	SHC adaptor protein 1	Homo sapiens	59-62
18179358-3	2008	Our study shows that the thiol status of the Trx/Prx-system can be modulated in vitro, but it appears to have high resistance against the oxidative stress in COPD.	Sulfhydryl Compounds	25-30	thioredoxin	Homo sapiens	45-48
18179358-3	2008	Our study shows that the thiol status of the Trx/Prx-system can be modulated in vitro, but it appears to have high resistance against the oxidative stress in COPD.	Sulfhydryl Compounds	25-30	periaxin	Homo sapiens	49-52
17941088-8	2008	The thiol antioxidant, N-acetyl cysteine (NAC), completely inhibited stretch- and Ang II-induced apoptosis.	Sulfhydryl Compounds	4-9	angiotensinogen	Homo sapiens	82-88
18262489-1	2008	Using a redox-inert methyl acceptor, we show that betaine-homocysteine S-methyltransferase (BHMT) requires a thiol reducing agent for activity.	Sulfhydryl Compounds	109-114	betaine-homocysteine methyltransferase	Mus musculus	50-90
18262489-1	2008	Using a redox-inert methyl acceptor, we show that betaine-homocysteine S-methyltransferase (BHMT) requires a thiol reducing agent for activity.	Sulfhydryl Compounds	109-114	betaine-homocysteine methyltransferase	Mus musculus	92-96
18262489-5	2008	Thiol modification experiments indicate that a disulfide bond is formed between two of the three zinc-binding ligands when BHMT is inactive in a reducing agent-free buffer, and that this disulfide can be readily reduced with the concomitant restoration of activity by re-establishing reducing conditions.	Sulfhydryl Compounds	0-5	betaine-homocysteine methyltransferase	Mus musculus	123-127
18055186-4	2008	Fab" fragments were then immobilized onto these surfaces via a thiol-disulfide interchange reaction and the reactivity of antibodies with antigens was investigated.	Sulfhydryl Compounds	63-68	FA complementation group B	Homo sapiens	0-3
18279387-1	2008	2-Cys peroxiredoxins (2-Cys Prx) are ubiquitous thiol-containing peroxidases that have been implicated in antioxidant defense and signal transduction.	Sulfhydryl Compounds	48-53	periaxin	Homo sapiens	28-31
18279387-5	2008	More importantly, we found that ATP facilitates the autophosphorylation of 2-Cys Prx when the protein is successively reduced with thiol-bearing compounds and oxidized with hydroperoxides or quinones.	Sulfhydryl Compounds	131-136	periaxin	Homo sapiens	81-84
18361512-4	2008	A two-step mechanism of NQO1 activation is proposed involving (i) oxidation of diphenol inducers to their quinone derivatives and (ii) oxidation of two highly reactive thiol groups by these quinones of a protein involved in NQO1 induction.	Sulfhydryl Compounds	168-173	NAD(P)H quinone dehydrogenase 1	Homo sapiens	24-28
18361512-4	2008	A two-step mechanism of NQO1 activation is proposed involving (i) oxidation of diphenol inducers to their quinone derivatives and (ii) oxidation of two highly reactive thiol groups by these quinones of a protein involved in NQO1 induction.	Sulfhydryl Compounds	168-173	NAD(P)H quinone dehydrogenase 1	Homo sapiens	224-228
18313239-0	2008	Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase.	Sulfhydryl Compounds	22-27	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	85-101
18295335-2	2008	The extracellular domain of the human complement receptor 2 (CR2/CD21) is released by proteolytic cleavage as a soluble protein through a variety of stimuli including the thiol antioxidants N-acetylcysteine (NAC) and glutathione (GSH), and the oxidant pervanadate (PV).	Sulfhydryl Compounds	171-176	complement receptor 2	Mus musculus	65-69
18074210-3	2008	Results reveal that PDI has a greater relative impact on thiol-disulfide reshuffling (isomerization) reactions and consequently the structure-forming step in oxidative folding at pH 7, as opposed to pH"s 8 and 9.	Sulfhydryl Compounds	57-62	prolyl 4-hydroxylase subunit beta	Homo sapiens	20-23
18074210-4	2008	These results suggest that PDI, which possesses an anomalously low thiol pKa, is fine-tuned to catalyze oxidative folding in the lumen of the endoplasmic reticulum where the ambient pH of approximately 7 would otherwise retard thioldisulfide exchange reactions and hinder acquisition of the native fold.	Sulfhydryl Compounds	67-72	prolyl 4-hydroxylase subunit beta	Homo sapiens	27-30
18313239-7	2008	However, 3-hydroxy-3-methylglutaryl coenzyme A synthase 2 (HMG-CoA synthase) had significantly decreased levels of reduced thiols and activity after APAP treatment.	Sulfhydryl Compounds	123-129	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	59-75
18313239-9	2008	Similarly, catalase, a key enzyme in hydrogen peroxide metabolism, also showed modification in protein thiol content.	Sulfhydryl Compounds	103-108	catalase	Homo sapiens	11-19
18199742-5	2008	Using site-directed mutagenesis in combination with heterologous expression in Xenopus oocytes, we have identified a C-terminal intramembranous cysteine residue of hCNT3 (Cys-561) that reversibly binds the hydrophilic thiol-reactive reagent p-chloromercuribenzene sulfonate (PCMBS).	Sulfhydryl Compounds	218-223	solute carrier family 28 member 3	Homo sapiens	164-169
18230399-3	2008	Here we developed a phage display-based biochemical assay, PHESELECTOR (Phage ELISA for Selection of Reactive Thiols) to rapidly screen reactive thiol groups on antibody fragments without interfering with their antigen binding, using trastuzumab-Fab (hu4D5Fab) as a model system.	Sulfhydryl Compounds	145-150	FA complementation group B	Homo sapiens	246-249
18311924-1	2008	We report the involvement of transmembrane domain 4 (TM4) of hASBT in forming the putative translocation pathway, using cysteine-scanning mutagenesis in conjunction with solvent-accessibility studies using the membrane-impermeant, sulfhydryl-specific methanethiosulfonate reagents.	Sulfhydryl Compounds	231-241	solute carrier family 10 member 2	Homo sapiens	61-66
18230399-7	2008	The poor correlation between fractional solvent accessibility and thiol reactivity of the engineered hu4D5Fab variants indicated the value of PHESELECTOR biochemical assay to identify reactive thiol groups on the antibody-Fab surface.	Sulfhydryl Compounds	193-198	FA complementation group B	Homo sapiens	106-109
18206984-6	2008	We also found that GPx4 +/- LFs have lower mitochondrial membrane potential, greater cardiolipin oxidation, and lower amounts of reduced thiols relative to GPx4 +/+ LFs, but are more resistant than GPx4 +/+ LFs to further decrements in these endpoints following PCOOH treatment.	Sulfhydryl Compounds	137-143	glutathione peroxidase 4	Mus musculus	19-23
18178549-0	2008	ERp44 mediates a thiol-independent retention of formylglycine-generating enzyme in the endoplasmic reticulum.	Sulfhydryl Compounds	17-22	endoplasmic reticulum protein 44	Homo sapiens	0-5
18206667-1	2008	Thimet oligopeptidase (EC 3.4.24.15; EP24.15) is a thiol-rich metallopeptidase ubiquitously distributed in mammalian tissues and involved in oligopeptide metabolism both within and outside cells.	Sulfhydryl Compounds	51-56	thimet oligopeptidase 1	Homo sapiens	0-21
18206667-1	2008	Thimet oligopeptidase (EC 3.4.24.15; EP24.15) is a thiol-rich metallopeptidase ubiquitously distributed in mammalian tissues and involved in oligopeptide metabolism both within and outside cells.	Sulfhydryl Compounds	51-56	thimet oligopeptidase 1	Rattus norvegicus	37-44
18187315-1	2008	Electrochemical label free DNA hybridization discrimination of the brain tumor sequence CK20 has been made at the gold-thiol and thiol diluent binary and ternary mixed monolayer interfaces in presence of the [Fe(CN)6](3-) and double stranded DNA (dsDNA) specific cationic intercalators, proflavine (PF) and methylene blue (MB), respectively.	Sulfhydryl Compounds	119-124	keratin 20	Homo sapiens	88-92
18187315-1	2008	Electrochemical label free DNA hybridization discrimination of the brain tumor sequence CK20 has been made at the gold-thiol and thiol diluent binary and ternary mixed monolayer interfaces in presence of the [Fe(CN)6](3-) and double stranded DNA (dsDNA) specific cationic intercalators, proflavine (PF) and methylene blue (MB), respectively.	Sulfhydryl Compounds	129-134	keratin 20	Homo sapiens	88-92
18177487-4	2008	In contrast, iodoacetoamide (IAA) that binds to thiol side chain of cysteine blocked the activation of c-Src by HgCl(2).	Sulfhydryl Compounds	48-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	103-108
18243695-0	2008	Thiol-based angiotensin-converting enzyme 2 inhibitors: P1" modifications for the exploration of the S1" subsite.	Sulfhydryl Compounds	0-5	angiotensin converting enzyme 2	Homo sapiens	12-43
18322093-3	2008	We have used electrophysiological methods and measurements of intracellular calcium concentration ([Ca(2+)](i)) to show that TRPA1 is activated by several classes of endogenous thiol-reactive molecules.	Sulfhydryl Compounds	177-182	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	125-130
18274674-10	2008	We propose that reduced PDI activates TF by isomerization of a mixed disulfide and a free thiol to an intramolecular disulfide.	Sulfhydryl Compounds	90-95	prolyl 4-hydroxylase, beta polypeptide	Mus musculus	24-27
18274674-10	2008	We propose that reduced PDI activates TF by isomerization of a mixed disulfide and a free thiol to an intramolecular disulfide.	Sulfhydryl Compounds	90-95	coagulation factor III	Mus musculus	38-40
18199679-9	2008	We report that celastrol"s biological effects, including inhibition of glucocorticoid receptor activity, can be blocked by the addition of excess free thiol, suggesting a chemical mechanism for biological activity based on modification of key reactive thiols by this natural product.	Sulfhydryl Compounds	151-156	nuclear receptor subfamily 3 group C member 1	Homo sapiens	71-94
18094169-6	2008	If activation is done in the presence of an alkylator, this will modify the isomerization-active thiol in the SU of Env and arrest Env at an intermediate stage, the isomerization-arrested state (IAS) of its activation pathway.	Sulfhydryl Compounds	97-102	endogenous retrovirus group K member 20	Homo sapiens	116-119
18302761-0	2008	NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols.	Sulfhydryl Compounds	139-145	T cell leukemia homeobox 2	Homo sapiens	0-3
18157936-5	2008	Our results suggest that ALDH-2 has an indirect antioxidative property independent of its thiol-moiety in disease states of cardiovascular oxidative stress.	Sulfhydryl Compounds	90-95	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	25-31
18302761-11	2008	CONCLUSION: The results suggested that NCX-4040 could resensitize drug-resistant ovarian cancer cells to cisplatin possibly by depletion of cellular thiols.	Sulfhydryl Compounds	149-155	T cell leukemia homeobox 2	Homo sapiens	39-42
18062931-4	2008	The mechanism for this effect has been proposed to involve thiol-dependent modulation of Keap1 leading to loss of its ability to negatively regulate Nrf2.	Sulfhydryl Compounds	59-64	kelch like ECH associated protein 1	Homo sapiens	89-94
18062931-4	2008	The mechanism for this effect has been proposed to involve thiol-dependent modulation of Keap1 leading to loss of its ability to negatively regulate Nrf2.	Sulfhydryl Compounds	59-64	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153
18062931-6	2008	Here we show that nitric oxide and S-nitrosocysteine (CSNO) cause time- and dose-dependent Keap1 thiol modification.	Sulfhydryl Compounds	97-102	kelch like ECH associated protein 1	Homo sapiens	91-96
18155723-0	2008	Thiol compounds inhibit the formation of amyloid fibrils by beta 2-microglobulin at neutral pH.	Sulfhydryl Compounds	0-5	beta-2-microglobulin	Homo sapiens	60-80
18231933-5	2008	Third, our laboratory showed that an unpaired thiol in the GPVI cytoplasmic tail undergoes rapid oxidation to form GPVI homodimers following ligand binding, preceding GPVI signaling and ectodomain metalloproteolysis, and indicating formation of an oxidative submembranous environment in activated platelets.	Sulfhydryl Compounds	46-51	glycoprotein VI platelet	Homo sapiens	59-63
18177270-9	2008	ERp44 inhibits the secretion of adiponectin oligomers through a thiol-mediated retention.	Sulfhydryl Compounds	64-69	endoplasmic reticulum protein 44	Homo sapiens	0-5
18177270-9	2008	ERp44 inhibits the secretion of adiponectin oligomers through a thiol-mediated retention.	Sulfhydryl Compounds	64-69	adiponectin, C1Q and collagen domain containing	Homo sapiens	32-43
18283338-7	2008	Notably, treatment with hydrogen peroxide duplicated the effects of ATM deficiency in cultured thymocytes, and treatment with the novel cell-permeable thiol antioxidant N-acetylcysteine amide (AD4) reduced elevated p-eIF2alpha levels in thymocytes of Atm-/- mice.	Sulfhydryl Compounds	151-156	eukaryotic translation initiation factor 2A	Mus musculus	217-226
18283338-7	2008	Notably, treatment with hydrogen peroxide duplicated the effects of ATM deficiency in cultured thymocytes, and treatment with the novel cell-permeable thiol antioxidant N-acetylcysteine amide (AD4) reduced elevated p-eIF2alpha levels in thymocytes of Atm-/- mice.	Sulfhydryl Compounds	151-156	ataxia telangiectasia mutated	Mus musculus	251-254
18082636-2	2008	In the present study we tested a novel thiol compound, N-acetylcysteine amide (AD4), the amide form of N-acetyl cysteine (NAC) for its antioxidant effects.	Sulfhydryl Compounds	39-44	presenilin 2	Homo sapiens	79-82
17936362-1	2008	Cell surface and growth-related NADH oxidases with protein disulfide-thiol interchange activity, ECTO-NOX, exhibit copper-dependent, clock-related, temperature-independent and entrainable patterns of regular oscillations in the rate of oxidation of NAD(P)H as do aqueous solutions of copper salts.	Sulfhydryl Compounds	69-74	tripartite motif containing 33	Homo sapiens	97-101
18077010-9	2008	The effect of thiol reagents on human TIM was also assayed; it is 180-fold less sensitive than GlTIM.	Sulfhydryl Compounds	14-19	Rho guanine nucleotide exchange factor 5	Homo sapiens	38-41
18231933-5	2008	Third, our laboratory showed that an unpaired thiol in the GPVI cytoplasmic tail undergoes rapid oxidation to form GPVI homodimers following ligand binding, preceding GPVI signaling and ectodomain metalloproteolysis, and indicating formation of an oxidative submembranous environment in activated platelets.	Sulfhydryl Compounds	46-51	glycoprotein VI platelet	Homo sapiens	115-119
18231933-5	2008	Third, our laboratory showed that an unpaired thiol in the GPVI cytoplasmic tail undergoes rapid oxidation to form GPVI homodimers following ligand binding, preceding GPVI signaling and ectodomain metalloproteolysis, and indicating formation of an oxidative submembranous environment in activated platelets.	Sulfhydryl Compounds	46-51	glycoprotein VI platelet	Homo sapiens	115-119
17920235-10	2008	In summary, inhibition of NF-kappaB sensitizes liver cells to toxicity linked to GSH depletion, probably accelerating the processes of thiol homeostasis deregulation and induction of apoptosis through a mechanism mediated by p38 MAPK.	Sulfhydryl Compounds	135-140	nuclear factor kappa B subunit 1	Homo sapiens	26-35
18203233-5	2008	Annexin A5 (anxA5)-VSOP utilizing thiol chemistry was generated to couple biologically active anxA5 to VSOPs for in vivo MRI of apoptosis.	Sulfhydryl Compounds	34-39	annexin A5	Homo sapiens	0-10
18203233-5	2008	Annexin A5 (anxA5)-VSOP utilizing thiol chemistry was generated to couple biologically active anxA5 to VSOPs for in vivo MRI of apoptosis.	Sulfhydryl Compounds	34-39	annexin A5	Homo sapiens	12-17
18203233-5	2008	Annexin A5 (anxA5)-VSOP utilizing thiol chemistry was generated to couple biologically active anxA5 to VSOPs for in vivo MRI of apoptosis.	Sulfhydryl Compounds	34-39	hydrogen voltage gated channel 1	Homo sapiens	19-23
18203233-5	2008	Annexin A5 (anxA5)-VSOP utilizing thiol chemistry was generated to couple biologically active anxA5 to VSOPs for in vivo MRI of apoptosis.	Sulfhydryl Compounds	34-39	annexin A5	Homo sapiens	94-99
18166048-2	2008	The nanoparticles can be removed from the GR active site with thiol reagents such as 2-mercaptoethanol.	Sulfhydryl Compounds	62-67	glutathione-disulfide reductase	Homo sapiens	42-44
17681686-4	2008	HSA can build dimers and higher aggregates because of a free thiol group present in the molecule.	Sulfhydryl Compounds	61-66	albumin	Homo sapiens	0-3
18078750-0	2008	Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite.	Sulfhydryl Compounds	0-5	angiotensin converting enzyme 2	Homo sapiens	12-43
18078750-1	2008	Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor.	Sulfhydryl Compounds	70-75	angiotensin I converting enzyme	Homo sapiens	87-90
18078750-1	2008	Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor.	Sulfhydryl Compounds	70-75	membrane metalloendopeptidase	Homo sapiens	91-94
18078750-1	2008	Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor.	Sulfhydryl Compounds	70-75	angiotensin converting enzyme 2	Homo sapiens	117-121
18088104-3	2008	272, 2557-2565) that the chemical modification of Cys 85 residue of S100A1 protein by disulfide bond formation with small thiols such as glutathione, cysteine, or beta-mercaptoethanol (betaME) leads to a dramatic increase of the protein affinity for calcium.	Sulfhydryl Compounds	122-128	S100 calcium binding protein A1	Homo sapiens	68-74
17961071-5	2008	For example, protein disulfide isomerase (PDI) can provide neuroprotection from misfolded proteins or endoplasmic reticulum stress through its molecular chaperone and thiol-disulfide oxidoreductase activities.	Sulfhydryl Compounds	167-172	prolyl 4-hydroxylase subunit beta	Homo sapiens	13-40
18023956-2	2008	The thioredoxin (Trx) system in endothelial cells plays a major role in the maintenance of cellular thiol redox balance, and is critical for cell survival.	Sulfhydryl Compounds	100-105	thioredoxin	Homo sapiens	4-15
18023956-2	2008	The thioredoxin (Trx) system in endothelial cells plays a major role in the maintenance of cellular thiol redox balance, and is critical for cell survival.	Sulfhydryl Compounds	100-105	thioredoxin	Homo sapiens	17-20
18052254-0	2008	Oxygen-induced radical intermediates in the nNOS oxygenase domain regulated by L-arginine, tetrahydrobiopterin, and thiol.	Sulfhydryl Compounds	116-121	nitric oxide synthase 1	Homo sapiens	44-48
18052254-17	2008	This new role of thiol found only for nNOS may be significant in neurodegenerative diseases.	Sulfhydryl Compounds	17-22	nitric oxide synthase 1	Homo sapiens	38-42
17961071-5	2008	For example, protein disulfide isomerase (PDI) can provide neuroprotection from misfolded proteins or endoplasmic reticulum stress through its molecular chaperone and thiol-disulfide oxidoreductase activities.	Sulfhydryl Compounds	167-172	prolyl 4-hydroxylase subunit beta	Homo sapiens	42-45
18383823-9	2008	Treatment with the thiol antioxidant, L-cysteine (&gt;0.2 mM), completely abrogated the VK3-induced phosphorylation of ERK, but not the JNK, and inhibition of proliferation.	Sulfhydryl Compounds	19-24	mitogen-activated protein kinase 1	Homo sapiens	119-122
18095874-2	2008	GST-SlIDE was characterized as a neutral thiol-dependent metallopeptidase with insulinase activity: the recombinant enzyme cleaved the oxidized insulin B chain at eight peptide bonds, six of which are also targets of human IDE.	Sulfhydryl Compounds	41-46	insulin degrading enzyme	Solanum lycopersicum	4-9
17988078-0	2008	A versatile bifunctional chelate for radiolabeling humanized anti-CEA antibody with In-111 and Cu-64 at either thiol or amino groups: PET imaging of CEA-positive tumors with whole antibodies.	Sulfhydryl Compounds	111-116	CEA cell adhesion molecule 3	Homo sapiens	66-69
18067244-3	2008	The new thiol-active reagents were labeled cytoplasmic cysteine 140 and 316 in rhodopsin (Rh), a G protein coupled receptor (GPCR).	Sulfhydryl Compounds	8-13	rhodopsin	Homo sapiens	79-88
18067244-3	2008	The new thiol-active reagents were labeled cytoplasmic cysteine 140 and 316 in rhodopsin (Rh), a G protein coupled receptor (GPCR).	Sulfhydryl Compounds	8-13	rhodopsin	Homo sapiens	90-92
18095874-2	2008	GST-SlIDE was characterized as a neutral thiol-dependent metallopeptidase with insulinase activity: the recombinant enzyme cleaved the oxidized insulin B chain at eight peptide bonds, six of which are also targets of human IDE.	Sulfhydryl Compounds	41-46	insulin degrading enzyme	Homo sapiens	79-89
18095874-2	2008	GST-SlIDE was characterized as a neutral thiol-dependent metallopeptidase with insulinase activity: the recombinant enzyme cleaved the oxidized insulin B chain at eight peptide bonds, six of which are also targets of human IDE.	Sulfhydryl Compounds	41-46	insulin	Homo sapiens	79-86
18095874-2	2008	GST-SlIDE was characterized as a neutral thiol-dependent metallopeptidase with insulinase activity: the recombinant enzyme cleaved the oxidized insulin B chain at eight peptide bonds, six of which are also targets of human IDE.	Sulfhydryl Compounds	41-46	insulin degrading enzyme	Homo sapiens	6-9
18054488-0	2008	Novel thiol-based TACE inhibitors.	Sulfhydryl Compounds	6-11	ADAM metallopeptidase domain 17	Homo sapiens	18-22
19734126-2	2008	To measure formation of thiols a turbimetric insulin assay was used.	Sulfhydryl Compounds	24-30	insulin	Homo sapiens	45-52
19734126-7	2008	Inclusion of reduced serum albumin as a source of free thiols for the protein disulfide interchange activity catalyzed by ENOX2 failed to result in insulin reduction in the presence of ENOX2.	Sulfhydryl Compounds	55-61	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	122-127
18054488-1	2008	Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.	Sulfhydryl Compounds	47-52	sarcosine dehydrogenase	Homo sapiens	40-43
18054488-2	2008	A series of potent thiol-containing aryl sulfone TACE inhibitors were designed and synthesized.	Sulfhydryl Compounds	19-24	ADAM metallopeptidase domain 17	Homo sapiens	49-53
18226399-4	2008	N-acetylcysteine (NAC) is a thiol molecule that has direct and indirect antioxidant effects which decrease reactive oxidant species and increase the bioavailability of the DDAH enzyme.	Sulfhydryl Compounds	28-33	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	172-176
18028487-1	2008	Platelet protein disulphide isomerase (PDI) has a role in platelet aggregation, probably targeting a thiol-containing platelet surface protein.	Sulfhydryl Compounds	101-106	prolyl 4-hydroxylase subunit beta	Homo sapiens	39-42
18028487-2	2008	The thiol-containing P2Y(12) ADP receptor is involved in aggregation induced by most agonists and may be the target of PDI.	Sulfhydryl Compounds	4-9	prolyl 4-hydroxylase subunit beta	Homo sapiens	119-122
18028487-3	2008	By excluding the P2Y(12) pathway and using the anti-PDI antibody RL90 this study showed that PDI targets a non-P2Y(12) thiol-protein in aggregation.	Sulfhydryl Compounds	119-124	prolyl 4-hydroxylase subunit beta	Homo sapiens	52-55
18028487-3	2008	By excluding the P2Y(12) pathway and using the anti-PDI antibody RL90 this study showed that PDI targets a non-P2Y(12) thiol-protein in aggregation.	Sulfhydryl Compounds	119-124	prolyl 4-hydroxylase subunit beta	Homo sapiens	93-96
18028487-4	2008	Anti-PDI inhibited signalling-independent activation of the thiol-containing fibrinogen receptor alphaIIbbeta3 by Mn(2+), suggesting that PDI directly interacts with alphaIIbbeta3.	Sulfhydryl Compounds	60-65	prolyl 4-hydroxylase subunit beta	Homo sapiens	5-8
18028487-4	2008	Anti-PDI inhibited signalling-independent activation of the thiol-containing fibrinogen receptor alphaIIbbeta3 by Mn(2+), suggesting that PDI directly interacts with alphaIIbbeta3.	Sulfhydryl Compounds	60-65	prolyl 4-hydroxylase subunit beta	Homo sapiens	138-141
18028487-5	2008	The thiol-containing form of PDI increased on the platelet surface with platelet activation, suggesting that active PDI readily becomes available for redox regulation of alphaIIbbeta3.	Sulfhydryl Compounds	4-9	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
18028487-5	2008	The thiol-containing form of PDI increased on the platelet surface with platelet activation, suggesting that active PDI readily becomes available for redox regulation of alphaIIbbeta3.	Sulfhydryl Compounds	4-9	prolyl 4-hydroxylase subunit beta	Homo sapiens	116-119
17200984-6	2008	The NAC administration to control and intoxicated animals (three times at doses of 150 mg/kg) elevated low-molecular-weight thiols in the liver.	Sulfhydryl Compounds	124-130	X-linked Kx blood group	Homo sapiens	4-7
17200984-9	2008	The in vitro exposure of human red blood cells to NAC increased the cellular low-molecular-weight thiol levels and retarded tert-butylhydroperoxide-induced cellular thiol depletion and membrane lipid peroxidation as well as effectively inhibited hypochlorous acid-induced erythrocyte lysis.	Sulfhydryl Compounds	98-103	X-linked Kx blood group	Homo sapiens	50-53
17200984-9	2008	The in vitro exposure of human red blood cells to NAC increased the cellular low-molecular-weight thiol levels and retarded tert-butylhydroperoxide-induced cellular thiol depletion and membrane lipid peroxidation as well as effectively inhibited hypochlorous acid-induced erythrocyte lysis.	Sulfhydryl Compounds	165-170	X-linked Kx blood group	Homo sapiens	50-53
17200984-10	2008	Thus, NAC can replenish non-protein cellular thiols and protect membrane lipids and proteins due to its direct radical-scavenging properties, but it did not attenuate hepatotoxicity in the acute rat CCl4-intoxication model.	Sulfhydryl Compounds	45-51	X-linked Kx blood group	Homo sapiens	6-9
19029635-8	2008	Upon intracellular thiol stimulation, the presence of AChE effectors (either acetylcholine or velnacrine) decreases erythrocyte aggregation and elongation indexes.	Sulfhydryl Compounds	19-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	54-58
18373941-5	2008	In this study, we have taken advantage of a new scaffold, hGSTZ1-1, in which there are two serine residues in the active site, to achieve both high thiol selectivity and highly catalytic efficiency.	Sulfhydryl Compounds	148-153	glutathione S-transferase zeta 1	Homo sapiens	58-66
18533362-2	2008	This biotransformation involves two separate enzymes, glyoxalase I and glyoxalase II, which bring about two consecutive reactions involving the thiol-containing tripeptide glutathione as a cofactor.	Sulfhydryl Compounds	144-149	glyoxalase I	Homo sapiens	54-66
18533362-2	2008	This biotransformation involves two separate enzymes, glyoxalase I and glyoxalase II, which bring about two consecutive reactions involving the thiol-containing tripeptide glutathione as a cofactor.	Sulfhydryl Compounds	144-149	hydroxyacylglutathione hydrolase	Homo sapiens	71-84
17891450-8	2008	These findings demonstrate that D3T reacts with thiols, particularly a dithiol, generating superoxide, which may provide a mechanistic explanation for induction of Nrf2-dependent phase 2 enzymes by D3T.	Sulfhydryl Compounds	48-54	NFE2 like bZIP transcription factor 2	Homo sapiens	164-168
18231625-8	2008	Increased methemoglobin leads to significant reduction in membrane GSH, which may cause protein thiol oxidation.	Sulfhydryl Compounds	96-101	hemoglobin subunit gamma 2	Homo sapiens	10-23
18755394-0	2008	Boric acid inhibits LPS-induced TNF-alpha formation through a thiol-dependent mechanism in THP-1 cells.	Sulfhydryl Compounds	62-67	tumor necrosis factor	Homo sapiens	32-41
18755394-9	2008	These results indicate that BA may have anti-inflammatory effect in the LPS-stimulated inflammation and the effect of BA on TNF-alpha secretion may be induced via a thiol-dependent mechanism.	Sulfhydryl Compounds	165-170	tumor necrosis factor	Homo sapiens	124-133
19157017-6	2008	Proteome-wide approaches also contributed to establish the functions of the thioredoxin and glutathione pathways in eukaryotic cytoplasmic thiol-redox control.	Sulfhydryl Compounds	139-144	thioredoxin	Homo sapiens	76-87
18209575-5	2008	These data suggest that thiol-disulfide exchange permits reduction of disulfide groups in thrombin and fibrinogen, altering their tertiary structure and physiological function.	Sulfhydryl Compounds	24-29	coagulation factor II, thrombin	Homo sapiens	90-98
18209575-5	2008	These data suggest that thiol-disulfide exchange permits reduction of disulfide groups in thrombin and fibrinogen, altering their tertiary structure and physiological function.	Sulfhydryl Compounds	24-29	fibrinogen beta chain	Homo sapiens	103-113
18167590-4	2007	The data show the organization of alkanethiol SAMs occurs at approximately the same rate for aliphatic chain lengths in the range of C(9)-C(16), as long as the thiol is readily soluble in the solvent system used.	Sulfhydryl Compounds	40-45	methionine adenosyltransferase 1A	Homo sapiens	46-50
18160846-0	2007	A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha.	Sulfhydryl Compounds	8-13	hypoxia inducible factor 1, alpha subunit	Mus musculus	125-156
18079675-5	2007	An optimized purification strategy and the presence of molar excesses of a thiol-based reducing agent yielded highly pure xIRBP in a soluble, stable and active form, free of its fusion partner.	Sulfhydryl Compounds	75-80	retinol binding protein 3 L homeolog	Xenopus laevis	122-127
17997562-2	2007	The system comprising substrate, silane, and initiator (ACCN) mixed in aqueous medium at 100 degrees C worked well for both hydrophilic and hydrophobic substrates, with the only variation that an amphiphilic thiol was also needed in case of the water-soluble compounds.	Sulfhydryl Compounds	208-213	acid sensing ion channel subunit 2	Homo sapiens	56-60
17925407-5	2007	In this study, we demonstrate that some of the plasma VWF multimers contain surface-exposed free thiols.	Sulfhydryl Compounds	97-103	von Willebrand factor	Homo sapiens	54-57
17925407-7	2007	The shear-induced thiol-disulfide exchange increases VWF binding to platelets.	Sulfhydryl Compounds	18-23	von Willebrand factor	Homo sapiens	53-56
17925407-8	2007	The thiol-disulfide exchange involves some or all of nine cysteine residues (Cys(889), Cys(898), Cys(2448), Cys(2451), Cys(2490), Cys(2491), Cys(2453), Cys(2528), and Cys(2533)) in the D3 and C domains as determined by mass spectrometry of the tryptic VWF peptides.	Sulfhydryl Compounds	4-9	von Willebrand factor	Homo sapiens	252-255
17925407-9	2007	These results suggest that the thiol-disulfide state may serve as an important structural determinant of VWF adhesion activity and can be modified by fluid shear stress.	Sulfhydryl Compounds	31-36	von Willebrand factor	Homo sapiens	105-108
18070357-6	2007	alpha- and beta-actin were both glutathionylated when incubated with reduced glutathione (GSH) combined with diamide as a thiol oxidant.	Sulfhydryl Compounds	122-127	POTE ankyrin domain family member F	Homo sapiens	11-21
18070357-8	2007	Glutathionylation of beta-actin by GSSG is likely to be mediated by a thiol-exchange mechanism whereas glutathionylation by GSH requires thiol oxidation.	Sulfhydryl Compounds	70-75	POTE ankyrin domain family member F	Homo sapiens	21-31
18070357-8	2007	Glutathionylation of beta-actin by GSSG is likely to be mediated by a thiol-exchange mechanism whereas glutathionylation by GSH requires thiol oxidation.	Sulfhydryl Compounds	137-142	POTE ankyrin domain family member F	Homo sapiens	21-31
17965288-9	2007	To determine whether one of the intracellular targets of thiol oxidation that leads to dilation is the redox-sensitive kinase p38 mitogen-activated protein (MAP) kinase, we evaluated dilation following the administration of the p38 inhibitor SB-203580 (10 microM).	Sulfhydryl Compounds	57-62	mitogen-activated protein kinase 14	Homo sapiens	126-129
17965288-12	2007	Taken together, our results show that an active component of cardiac metabolic dilation, like that of H2O2, produces dilation by the oxidation of thiols, which are predominantly intracellular and dependent activation on the p38 MAP kinase.	Sulfhydryl Compounds	146-152	mitogen-activated protein kinase 14	Homo sapiens	224-238
17941699-11	2007	The results demonstrate fundamental differences between the pharmacological properties of CA1 and CA4 that provide two possible explanations for their differential activities in vivo: oxidative activation to a quinone intermediate likely to bind to protein thiols and possibly to nucleic acids and stimulation of oxidative stress by enhancing superoxide/hydrogen peroxide production.	Sulfhydryl Compounds	257-263	carbonic anhydrase 4	Homo sapiens	98-101
17964869-7	2007	The thiol-titration and fluorescence experiment further indicate that rat mevalonate kinase A141C variant enzyme has a new disulfide bond, which makes the variant protein enhance its thermal activity and resist to urea denaturation.	Sulfhydryl Compounds	4-9	mevalonate kinase	Rattus norvegicus	74-91
18071269-1	2007	The conditional ero1-1 mutant, deficient in the ER-localized PDI oxidase Ero1p, is blocked in disulfide bond formation under restrictive conditions, such as high temperature, lack of oxygen, or high concentrations of membrane-permeant thiols.	Sulfhydryl Compounds	235-241	ER oxidoreductin	Saccharomyces cerevisiae S288C	16-22
18071269-1	2007	The conditional ero1-1 mutant, deficient in the ER-localized PDI oxidase Ero1p, is blocked in disulfide bond formation under restrictive conditions, such as high temperature, lack of oxygen, or high concentrations of membrane-permeant thiols.	Sulfhydryl Compounds	235-241	ER oxidoreductin	Saccharomyces cerevisiae S288C	73-78
18057706-6	2007	Further investigations found that redox imbalance due to thiol depletion caused increased NF-kappaB activation, and cyclooxygenase (COX)-2 and TNFalpha levels, both of which were suppressed by betaine treatment.	Sulfhydryl Compounds	57-62	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	116-138
18057706-7	2007	Based on both in vivo and in vitro data, we concluded that betaine exerts its efficacy by maintaining thiol status in the regulation of COX-2 and TNFalpha via NF-kappaB activation during aging.	Sulfhydryl Compounds	102-107	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	136-141
18057706-7	2007	Based on both in vivo and in vitro data, we concluded that betaine exerts its efficacy by maintaining thiol status in the regulation of COX-2 and TNFalpha via NF-kappaB activation during aging.	Sulfhydryl Compounds	102-107	tumor necrosis factor	Rattus norvegicus	146-154
17464275-8	2007	To accommodate the use of a bifunctional PEG for covalent assembly of binding and capturing modules, the MUC1 binding module was developed into a di-scFv-SH format and optimized for linker length and location of the free thiol in respect to Ag binding and site-specific conjugation.	Sulfhydryl Compounds	221-226	mucin 1, cell surface associated	Homo sapiens	105-109
17975886-6	2007	Although the control family, including NCX 4016 and conisogenic bromides and mesylates, cannot form a quinone, ARE activation and NQO1 induction were observed, compatible with slower SN2 reactions with thiol sensor proteins, and consequent ARE-luciferase and NQO1 induction.	Sulfhydryl Compounds	202-207	T cell leukemia homeobox 2	Homo sapiens	39-42
17645497-8	2007	Auranofin-mediated inhibition of STAT3 phosphorylation was recovered by pretreatment with antioxidants containing thiol groups.	Sulfhydryl Compounds	114-119	signal transducer and activator of transcription 3	Homo sapiens	33-38
17645497-10	2007	Thiol-group-reactive proteins may be involved in AF-induced suppression of JAK1/STAT3 phosphorylation.	Sulfhydryl Compounds	0-5	Janus kinase 1	Homo sapiens	75-79
17645497-10	2007	Thiol-group-reactive proteins may be involved in AF-induced suppression of JAK1/STAT3 phosphorylation.	Sulfhydryl Compounds	0-5	signal transducer and activator of transcription 3	Homo sapiens	80-85
17719596-2	2007	The amphiphilic colloidal nanoparticles are synthesized by grafting the amphiphilic and thermoresponsive polymer of thiol-terminated poly(N-isopropylacrylamide) to CdS and noble metal nanoparticles.	Sulfhydryl Compounds	116-121	CDP-diacylglycerol synthase 1	Homo sapiens	164-167
18047801-0	2007	Evidence of tandem repeat and extra thiol-groups resulted in the polymeric formation of bovine haptoglobin: a unique structure of Hp 2-2 phenotype.	Sulfhydryl Compounds	36-41	haptoglobin	Bos taurus	95-106
17900531-6	2007	The results show that thiol compounds affect MMPs expression and activity in different ways.	Sulfhydryl Compounds	22-27	matrix metallopeptidase 2	Homo sapiens	45-49
18025460-7	2007	Furthermore, DNA-bound p53 oxidation is shown in vivo by up-regulation of p53 and subsequent irradiation in the presence of a rhodium photooxidant to give a new p53 adduct that can be reversed with thiol treatment.	Sulfhydryl Compounds	198-203	tumor protein p53	Homo sapiens	23-26
18025460-7	2007	Furthermore, DNA-bound p53 oxidation is shown in vivo by up-regulation of p53 and subsequent irradiation in the presence of a rhodium photooxidant to give a new p53 adduct that can be reversed with thiol treatment.	Sulfhydryl Compounds	198-203	tumor protein p53	Homo sapiens	74-77
18025460-7	2007	Furthermore, DNA-bound p53 oxidation is shown in vivo by up-regulation of p53 and subsequent irradiation in the presence of a rhodium photooxidant to give a new p53 adduct that can be reversed with thiol treatment.	Sulfhydryl Compounds	198-203	tumor protein p53	Homo sapiens	74-77
17900531-9	2007	Although all thiols, these compounds have different properties and different cellular uptakes and metabolic characteristics, and this could explain, at least in part, their differential effects on MMPs.	Sulfhydryl Compounds	13-19	matrix metallopeptidase 2	Homo sapiens	197-201
17893047-6	2007	Pretreatment with MAPK inhibitors SB203580 and U0126, or addition of the exogenous thiol N-acetylcysteine, abrogated both p38(MAPK) and ERK2 activation as well as downstream effects on gene expression.	Sulfhydryl Compounds	83-88	mitogen-activated protein kinase 14	Mus musculus	122-125
17716616-1	2007	The Ellman method for assaying thiols is widely used for cholinesterase activity measurement.	Sulfhydryl Compounds	31-37	butyrylcholinesterase	Homo sapiens	57-71
17716616-2	2007	Cholinesterase activity is measured indirectly by quantifying the concentration of 5-thio-2-nitrobenzoic acid (TNB) ion formed in the reaction between the thiol reagent 5,5"-dithiobis-2-nitrobenzoic acid (DTNB) and thiocholine, a product of substrate (i.e., acetylthiocholine [ATCh]) hydrolysis by the cholinesterase.	Sulfhydryl Compounds	155-160	butyrylcholinesterase	Homo sapiens	0-14
17716616-2	2007	Cholinesterase activity is measured indirectly by quantifying the concentration of 5-thio-2-nitrobenzoic acid (TNB) ion formed in the reaction between the thiol reagent 5,5"-dithiobis-2-nitrobenzoic acid (DTNB) and thiocholine, a product of substrate (i.e., acetylthiocholine [ATCh]) hydrolysis by the cholinesterase.	Sulfhydryl Compounds	155-160	butyrylcholinesterase	Homo sapiens	302-316
17711389-5	2007	Here the authors demonstrate that PDI-1, PDI-2, and PDI-3 show comparable kinetic properties in catalyzing thiol:disulfide exchange reactions in two simple peptide-based assays.	Sulfhydryl Compounds	107-112	Protein disulfide-isomerase 1	Caenorhabditis elegans	34-39
17711389-5	2007	Here the authors demonstrate that PDI-1, PDI-2, and PDI-3 show comparable kinetic properties in catalyzing thiol:disulfide exchange reactions in two simple peptide-based assays.	Sulfhydryl Compounds	107-112	Protein disulfide-isomerase 2	Caenorhabditis elegans	41-46
17711389-5	2007	Here the authors demonstrate that PDI-1, PDI-2, and PDI-3 show comparable kinetic properties in catalyzing thiol:disulfide exchange reactions in two simple peptide-based assays.	Sulfhydryl Compounds	107-112	Protein disulfide-isomerase	Caenorhabditis elegans	52-57
17760507-6	2007	Thiol-protectant, N-acetylcysteine, significantly attenuated the NCX-4016-induced loss of cell viability, suggesting the role of alteration of thiol-redox status therein.	Sulfhydryl Compounds	0-5	T cell leukemia homeobox 2	Homo sapiens	65-68
17714694-7	2007	Data on membrane localization, Mg2+ dependence, sensitivity to thiol oxidizing agents and protection by N-acetylcysteine (NAC) and DTT strongly suggest the involvement of PTP1B, the major PTP of human RBC associated to and acting on Band 3.	Sulfhydryl Compounds	63-68	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	171-176
17941684-2	2007	In particular, thiol-reactive PEGs have been coupled to the cysteine 17 of granulocyte colony stimulating factor (G-CSF), which is known to be partially buried in a hydrophobic protein pocket.	Sulfhydryl Compounds	15-20	colony stimulating factor 3	Homo sapiens	75-112
17941684-2	2007	In particular, thiol-reactive PEGs have been coupled to the cysteine 17 of granulocyte colony stimulating factor (G-CSF), which is known to be partially buried in a hydrophobic protein pocket.	Sulfhydryl Compounds	15-20	colony stimulating factor 3	Homo sapiens	114-119
18032928-5	2007	Pre-incubation with thiol antioxidants glutathione or N-acetyl-cysteine (NAC, precursor of intracellular glutathione) almost abolished the cytotoxicity of salvicine, which also could be attenuated by the H(2)O(2)-specific scavenger catalase.	Sulfhydryl Compounds	20-25	catalase	Homo sapiens	232-240
17760507-6	2007	Thiol-protectant, N-acetylcysteine, significantly attenuated the NCX-4016-induced loss of cell viability, suggesting the role of alteration of thiol-redox status therein.	Sulfhydryl Compounds	143-148	T cell leukemia homeobox 2	Homo sapiens	65-68
17893047-6	2007	Pretreatment with MAPK inhibitors SB203580 and U0126, or addition of the exogenous thiol N-acetylcysteine, abrogated both p38(MAPK) and ERK2 activation as well as downstream effects on gene expression.	Sulfhydryl Compounds	83-88	mitogen-activated protein kinase 1	Mus musculus	136-140
17726030-6	2007	Two different types of ubiquitination were detected, one of which is thiol-sensitive, involves Cys(11) of Pex5p, and is necessary for the export of the receptor back into the cytosol.	Sulfhydryl Compounds	69-74	peroxisomal biogenesis factor 5	Homo sapiens	106-111
17640057-3	2007	Furthermore, it was shown that thiol-containing antioxidants completely blocked MOG-induced mitochondrial DeltaPsim loss and subsequent cell apoptosis, while the inhibition of apoptosis by benzyloxy-carbonyl-Val-Ala-Asp-fluoromethylketone only partially attenuated mitochondrial DeltaPsim loss, indicating that MOG-induced redox imbalance is an early event upstream to mitochondrial DeltaPsim loss and caspase-3 activation.	Sulfhydryl Compounds	31-36	myelin oligodendrocyte glycoprotein	Homo sapiens	80-83
17640057-3	2007	Furthermore, it was shown that thiol-containing antioxidants completely blocked MOG-induced mitochondrial DeltaPsim loss and subsequent cell apoptosis, while the inhibition of apoptosis by benzyloxy-carbonyl-Val-Ala-Asp-fluoromethylketone only partially attenuated mitochondrial DeltaPsim loss, indicating that MOG-induced redox imbalance is an early event upstream to mitochondrial DeltaPsim loss and caspase-3 activation.	Sulfhydryl Compounds	31-36	myelin oligodendrocyte glycoprotein	Homo sapiens	311-314
17693425-2	2007	We have shown that two enzymes catalyzing phosphorolytic cleavage of their substrates, namely purine nucleoside phosphorylase and glyceraldehyde-3-phosphate dehydrogenase, can reduce As(V) in presence of an appropriate thiol and their substrates.	Sulfhydryl Compounds	219-224	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	130-170
17924659-1	2007	A novel hydroquinone and NADH oxidase with protein disulfide-thiol interchange activity (designated ENOX2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, is absent from the surface of noncancer cells and from sera of healthy individuals.	Sulfhydryl Compounds	61-66	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	100-105
17924659-1	2007	A novel hydroquinone and NADH oxidase with protein disulfide-thiol interchange activity (designated ENOX2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, is absent from the surface of noncancer cells and from sera of healthy individuals.	Sulfhydryl Compounds	61-66	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	109-113
18066971-7	2007	Sulfhydryl (thiol-protective) agents, calcium chelators, antioxidants, and PLA(2)-specific inhibitors attenuated the MMC-induced PLA(2) activation, suggesting the role of thiols, reactive oxygen species (ROS), and calcium in the activation of PLA(2) in BPAECs.	Sulfhydryl Compounds	0-10	phospholipase A2 group IB	Homo sapiens	129-135
18066971-7	2007	Sulfhydryl (thiol-protective) agents, calcium chelators, antioxidants, and PLA(2)-specific inhibitors attenuated the MMC-induced PLA(2) activation, suggesting the role of thiols, reactive oxygen species (ROS), and calcium in the activation of PLA(2) in BPAECs.	Sulfhydryl Compounds	0-10	phospholipase A2 group IB	Homo sapiens	129-135
18066971-7	2007	Sulfhydryl (thiol-protective) agents, calcium chelators, antioxidants, and PLA(2)-specific inhibitors attenuated the MMC-induced PLA(2) activation, suggesting the role of thiols, reactive oxygen species (ROS), and calcium in the activation of PLA(2) in BPAECs.	Sulfhydryl Compounds	12-17	phospholipase A2 group IB	Homo sapiens	129-135
18066971-7	2007	Sulfhydryl (thiol-protective) agents, calcium chelators, antioxidants, and PLA(2)-specific inhibitors attenuated the MMC-induced PLA(2) activation, suggesting the role of thiols, reactive oxygen species (ROS), and calcium in the activation of PLA(2) in BPAECs.	Sulfhydryl Compounds	12-17	phospholipase A2 group IB	Homo sapiens	129-135
18066971-10	2007	This study established that PLA(2) activation through thiols, calcium, and oxidative stress was associated with the cytotoxicity of MMC in BPAECs, drawing attention to the involvement of PLA(2) signaling in the methylmercury-induced vascular endothelial dysfunctions.	Sulfhydryl Compounds	54-60	phospholipase A2 group IB	Homo sapiens	28-34
17947697-0	2007	Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages.	Sulfhydryl Compounds	69-74	interferon gamma	Mus musculus	20-29
17947697-0	2007	Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages.	Sulfhydryl Compounds	69-74	interferon beta 1, fibroblast	Mus musculus	35-43
17607746-2	2007	During these experiments we observed that thiolated albumin underwent thiol substitution (Alb-SS-X+RSH&lt;--&gt;Alb-SS-R+XSH) or dethiolation (Alb-SS-X+XSH&lt;--&gt;Alb-SH+XSSX), depending on the different pK(a) values of thiols involved in protein-thiol mixed disulfides (Alb-SS-X).	Sulfhydryl Compounds	42-47	albumin	Homo sapiens	90-93
17607746-2	2007	During these experiments we observed that thiolated albumin underwent thiol substitution (Alb-SS-X+RSH&lt;--&gt;Alb-SS-R+XSH) or dethiolation (Alb-SS-X+XSH&lt;--&gt;Alb-SH+XSSX), depending on the different pK(a) values of thiols involved in protein-thiol mixed disulfides (Alb-SS-X).	Sulfhydryl Compounds	42-47	albumin	Homo sapiens	112-115
17607746-2	2007	During these experiments we observed that thiolated albumin underwent thiol substitution (Alb-SS-X+RSH&lt;--&gt;Alb-SS-R+XSH) or dethiolation (Alb-SS-X+XSH&lt;--&gt;Alb-SH+XSSX), depending on the different pK(a) values of thiols involved in protein-thiol mixed disulfides (Alb-SS-X).	Sulfhydryl Compounds	42-47	albumin	Homo sapiens	112-115
17607746-2	2007	During these experiments we observed that thiolated albumin underwent thiol substitution (Alb-SS-X+RSH&lt;--&gt;Alb-SS-R+XSH) or dethiolation (Alb-SS-X+XSH&lt;--&gt;Alb-SH+XSSX), depending on the different pK(a) values of thiols involved in protein-thiol mixed disulfides (Alb-SS-X).	Sulfhydryl Compounds	42-47	albumin	Homo sapiens	112-115
17607746-2	2007	During these experiments we observed that thiolated albumin underwent thiol substitution (Alb-SS-X+RSH&lt;--&gt;Alb-SS-R+XSH) or dethiolation (Alb-SS-X+XSH&lt;--&gt;Alb-SH+XSSX), depending on the different pK(a) values of thiols involved in protein-thiol mixed disulfides (Alb-SS-X).	Sulfhydryl Compounds	42-47	albumin	Homo sapiens	112-115
17607746-2	2007	During these experiments we observed that thiolated albumin underwent thiol substitution (Alb-SS-X+RSH&lt;--&gt;Alb-SS-R+XSH) or dethiolation (Alb-SS-X+XSH&lt;--&gt;Alb-SH+XSSX), depending on the different pK(a) values of thiols involved in protein-thiol mixed disulfides (Alb-SS-X).	Sulfhydryl Compounds	70-75	albumin	Homo sapiens	90-93
17607746-5	2007	In turn, Alb-SS-X were dethiolated by the excess nonprotein SH groups because of the lower pK(a) value in mixed disulfide with respect to that of other thiols.	Sulfhydryl Compounds	152-158	albumin	Homo sapiens	9-12
17607746-6	2007	Dethiolation of Alb-SS-X was accompanied by formation of XSSX and Alb-SH up to equilibrium levels at 35 min, which were different for each thiol.	Sulfhydryl Compounds	2-7	albumin	Homo sapiens	16-19
17607746-6	2007	Dethiolation of Alb-SS-X was accompanied by formation of XSSX and Alb-SH up to equilibrium levels at 35 min, which were different for each thiol.	Sulfhydryl Compounds	2-7	albumin	Homo sapiens	66-69
17805346-3	2007	We show here that ERp44, a soluble protein involved in thiol-mediated retention, interacts with ERGIC-53.	Sulfhydryl Compounds	55-60	endoplasmic reticulum protein 44	Homo sapiens	18-23
17761673-6	2007	Using an antibody that specifically recognizes sulfinylated and sulfonylated Prxs, it is demonstrated that primary rat cortical nerve cells exposed to Abeta display a time-dependent increase in cysteine oxidation of the catalytic site of Prxs that can be blocked by the addition of the thiol-antioxidant N-acetylcysteine.	Sulfhydryl Compounds	286-291	amyloid beta precursor protein	Rattus norvegicus	151-156
17805346-3	2007	We show here that ERp44, a soluble protein involved in thiol-mediated retention, interacts with ERGIC-53.	Sulfhydryl Compounds	55-60	lectin, mannose binding 1	Homo sapiens	96-104
17805346-10	2007	In this process, ERp44 couples thiol-dependent assembly and quality control.	Sulfhydryl Compounds	31-36	endoplasmic reticulum protein 44	Homo sapiens	17-22
17714875-1	2007	The selenoenzyme sperm nuclei glutathione peroxidase (snGPx), also called the nuclear form of phospholipid hydroperoxide glutathione peroxidase (n-PHGPx), was found to be involved in the stabilization of condensed sperm chromatin, most likely by thiol to disulfide oxidation of the cysteine residues of the mammalian protamines, small nuclear basic proteins in the nuclei of sperm cells.	Sulfhydryl Compounds	246-251	glutathione peroxidase 4	Homo sapiens	17-52
17714875-1	2007	The selenoenzyme sperm nuclei glutathione peroxidase (snGPx), also called the nuclear form of phospholipid hydroperoxide glutathione peroxidase (n-PHGPx), was found to be involved in the stabilization of condensed sperm chromatin, most likely by thiol to disulfide oxidation of the cysteine residues of the mammalian protamines, small nuclear basic proteins in the nuclei of sperm cells.	Sulfhydryl Compounds	246-251	glutathione peroxidase 4	Homo sapiens	54-59
17714875-1	2007	The selenoenzyme sperm nuclei glutathione peroxidase (snGPx), also called the nuclear form of phospholipid hydroperoxide glutathione peroxidase (n-PHGPx), was found to be involved in the stabilization of condensed sperm chromatin, most likely by thiol to disulfide oxidation of the cysteine residues of the mammalian protamines, small nuclear basic proteins in the nuclei of sperm cells.	Sulfhydryl Compounds	246-251	glutathione peroxidase 4	Homo sapiens	147-152
17658243-0	2007	Accumulation of hypoxia-inducible factor-1alpha through a novel electrophilic, thiol antioxidant-sensitive mechanism.	Sulfhydryl Compounds	79-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-47
17937612-6	2007	Mechanistically, the process is an alternate substrate inactivation of GPx4 resulting from reactions of its selenenic form with thiols of GPx4 itself and other proteins.	Sulfhydryl Compounds	128-134	glutathione peroxidase 4	Homo sapiens	71-75
17937612-6	2007	Mechanistically, the process is an alternate substrate inactivation of GPx4 resulting from reactions of its selenenic form with thiols of GPx4 itself and other proteins.	Sulfhydryl Compounds	128-134	glutathione peroxidase 4	Homo sapiens	138-142
17937614-6	2007	Monomeric GPx4 is multifunctional: it acts as a reducing enzyme of peroxidized phospholipids and thiols and as a structural protein.	Sulfhydryl Compounds	97-103	glutathione peroxidase 4	Mus musculus	10-14
17658243-1	2007	15-deoxy-Delta(12,14)-prostaglandin-J(2) (15d-PGJ(2)) is a peroxisome-activated proliferator receptor-gamma (PPARgamma) agonist which contains an alpha,beta-unsaturated electrophilic ketone involved in nucleophilic addition reactions to thiols.	Sulfhydryl Compounds	237-243	peroxisome proliferator activated receptor gamma	Homo sapiens	59-107
17658243-7	2007	Taken together, these results point out to a new mechanism to increase pharmacologically the cell levels of HIF-1alpha through the electrophilic reaction of alpha,beta-unsaturated ketones with thiol groups.	Sulfhydryl Compounds	193-198	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-118
17658243-1	2007	15-deoxy-Delta(12,14)-prostaglandin-J(2) (15d-PGJ(2)) is a peroxisome-activated proliferator receptor-gamma (PPARgamma) agonist which contains an alpha,beta-unsaturated electrophilic ketone involved in nucleophilic addition reactions to thiols.	Sulfhydryl Compounds	237-243	peroxisome proliferator activated receptor gamma	Homo sapiens	109-118
17962739-0	2007	H14[NaP5W30O110] as a heterogeneous recyclable catalyst for the air oxidation of thiols under solvent free conditions.	Sulfhydryl Compounds	81-87	H1.4 linker histone, cluster member	Homo sapiens	0-3
17892489-5	2007	This includes a family of enzymes involved in catalyzing thiol-disulfide exchange in the endoplasmic reticulum, the protein disulfide isomerase (PDI) family.	Sulfhydryl Compounds	57-62	prolyl 4-hydroxylase subunit beta	Homo sapiens	116-143
17892489-5	2007	This includes a family of enzymes involved in catalyzing thiol-disulfide exchange in the endoplasmic reticulum, the protein disulfide isomerase (PDI) family.	Sulfhydryl Compounds	57-62	prolyl 4-hydroxylase subunit beta	Homo sapiens	145-148
18000722-11	2007	CONCLUSIONS: Obesity and insulin resistance appear to be associated with plasma protein oxidation and thiol concentrations.	Sulfhydryl Compounds	102-107	insulin	Homo sapiens	25-32
17761302-11	2007	These results suggest that thioredoxin can replace glutathione to promote the active thiol redox state necessary for caspase activity, and thus glutathione and thioredoxin regulate the mode of cisplatin toxicity in E47 cells via redox regulation of caspase activity.	Sulfhydryl Compounds	85-90	thioredoxin	Homo sapiens	27-38
17588140-3	2007	In this study, we show that the kinase activity of the non-receptor tyrosine kinase c-Abl is inhibited by in vitro thiol modification; specifically, the cysteine residues of c-Abl are modified by S-glutathionylation and by thiol alkylating agents such as 4-acetamido-4"-maleimidylstilbene-2,2"-disulfonic acid and N-ethylmaleimide.	Sulfhydryl Compounds	115-120	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-89
17588140-3	2007	In this study, we show that the kinase activity of the non-receptor tyrosine kinase c-Abl is inhibited by in vitro thiol modification; specifically, the cysteine residues of c-Abl are modified by S-glutathionylation and by thiol alkylating agents such as 4-acetamido-4"-maleimidylstilbene-2,2"-disulfonic acid and N-ethylmaleimide.	Sulfhydryl Compounds	115-120	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	174-179
17588140-3	2007	In this study, we show that the kinase activity of the non-receptor tyrosine kinase c-Abl is inhibited by in vitro thiol modification; specifically, the cysteine residues of c-Abl are modified by S-glutathionylation and by thiol alkylating agents such as 4-acetamido-4"-maleimidylstilbene-2,2"-disulfonic acid and N-ethylmaleimide.	Sulfhydryl Compounds	223-228	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-89
17588140-3	2007	In this study, we show that the kinase activity of the non-receptor tyrosine kinase c-Abl is inhibited by in vitro thiol modification; specifically, the cysteine residues of c-Abl are modified by S-glutathionylation and by thiol alkylating agents such as 4-acetamido-4"-maleimidylstilbene-2,2"-disulfonic acid and N-ethylmaleimide.	Sulfhydryl Compounds	223-228	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	174-179
17588140-4	2007	Modification of cysteine residues of c-Abl tyrosine kinase using glutathione disulfide and thiol alkylating agents corresponds to a concomitant loss of kinase activity.	Sulfhydryl Compounds	91-96	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	37-42
17031475-0	2007	Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27(kip1) translocation and retinoblastoma protein phosphorylation by 1"-acetoxychavicol acetate.	Sulfhydryl Compounds	9-14	zinc ribbon domain containing 2	Homo sapiens	82-85
17679146-8	2007	Our data suggests that Cu[DEDTC](2) toxicity is mediated through an increase in pro-apoptotic Bak/Bax via disruption of the peroxide and thiol metabolism.	Sulfhydryl Compounds	137-142	BCL2 antagonist/killer 1	Homo sapiens	94-97
17658470-1	2007	1,2-Naphthoquinone (1,2-NQ) is an atmospheric contaminant with electrophilic properties that allow it to react readily with protein thiol groups such as those found on the cAMP response element-binding protein (CREB), a transcription factor with conserved cysteine residues that regulate DNA binding.	Sulfhydryl Compounds	132-137	cAMP responsive element binding protein 1	Bos taurus	172-209
17658470-1	2007	1,2-Naphthoquinone (1,2-NQ) is an atmospheric contaminant with electrophilic properties that allow it to react readily with protein thiol groups such as those found on the cAMP response element-binding protein (CREB), a transcription factor with conserved cysteine residues that regulate DNA binding.	Sulfhydryl Compounds	132-137	cAMP responsive element binding protein 1	Bos taurus	211-215
17031475-0	2007	Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27(kip1) translocation and retinoblastoma protein phosphorylation by 1"-acetoxychavicol acetate.	Sulfhydryl Compounds	9-14	cyclin dependent kinase inhibitor 1B	Homo sapiens	86-90
17701050-1	2007	Thioredoxins are small thiol proteins that have a conserved active site sequence, WCGPC, and reduce disulfide bonds in various proteins using the two active site cysteines, a reaction that oxidizes thioredoxin and renders it inactive.	Sulfhydryl Compounds	23-28	Thioredoxin T	Drosophila melanogaster	198-209
17623874-4	2007	We tested the efficacy of the thiol-labeling fluorescent dye CM-SNARF in its ability to measure variations in GSH concentration using a visible-light flow cytometer.	Sulfhydryl Compounds	30-35	small NF90 (ILF3) associated RNA F	Homo sapiens	64-69
17134958-0	2007	Evidence for oxidative stress at elevated plasma thiol levels in chronic exposure to carbon disulfide (CS2) and coronary heart disease.	Sulfhydryl Compounds	49-54	chorionic somatomammotropin hormone 2	Homo sapiens	103-106
17712144-0	2007	Effect of thiol-containing molecule cysteamine on the induction of inducible nitric oxide synthase in hepatocytes.	Sulfhydryl Compounds	10-15	nitric oxide synthase 2	Rattus norvegicus	67-98
17953354-3	2007	The aim of this study was to determine the effect of a thiol-depleting agent, diethylmaleate (DEM), on the sensitivity of human breast cancer cells to ADM.	Sulfhydryl Compounds	55-60	adrenomedullin	Homo sapiens	151-154
17546662-1	2007	Glutaredoxins (Grxs) are glutathione-dependent oxidoreductases that belong to the thioredoxin superfamily catalyzing thiol-disulfide exchange reactions via active site cysteine residues.	Sulfhydryl Compounds	117-122	thioredoxin	Homo sapiens	82-93
17953354-4	2007	METHODS: The ADM-resistant human breast cancer MCF-7/ADM cell lines and ADM-sensitive MCF-7/S cell lines were treated by thiol-depleting agent DEM for 3 h respectively.	Sulfhydryl Compounds	121-126	adrenomedullin	Homo sapiens	13-16
17654760-0	2007	STM vizualization of thiol-containing peptide dendrimers on Au(111).	Sulfhydryl Compounds	21-26	sulfotransferase family 1A member 3	Homo sapiens	0-3
17655306-2	2007	Primary allylic selenosulfates (seleno Bunte salts) and selenocyanates transfer the allylic selenide moiety to thiols giving primary allylic selenosulfides, which undergo rearrangement in the presence of PPh3 with the loss of selenium to give allylically rearranged allyl alkyl sulfides.	Sulfhydryl Compounds	111-117	caveolin 1	Homo sapiens	204-208
17655306-4	2007	Alkyl secondary and tertiary allylic disulfides, formed by sulfide transfer from allylic heteroaryl disulfides to thiols, undergo desulfurative allylic rearrangement on treatment with PPh3 in methanolic acetonitrile at room temperature.	Sulfhydryl Compounds	114-120	caveolin 1	Homo sapiens	184-188
17561403-5	2007	The results suggested that the thiol-target PEGylation was more beneficial for IL-1ra.	Sulfhydryl Compounds	31-36	interleukin 1 receptor antagonist	Homo sapiens	79-85
17616140-1	2007	Ergothioneine is a native membrane-impermeable thiol compound that is specifically accumulated in cells via the organic cation transporter OCTN1.	Sulfhydryl Compounds	47-52	solute carrier family 22 member 4	Homo sapiens	139-144
17384142-7	2007	Decomposing peroxynitrite with FeTPPs or blocking oxidation using the thiol donor NAC blocked VEGF"s angiogenic functions in vitro and in vivo.	Sulfhydryl Compounds	70-75	X-linked Kx blood group	Homo sapiens	82-85
17586717-2	2007	Here, we show that Hsf1 activates the transcription of various target genes when cells are treated with oxidizing reagents, including the superoxide anion generators menadione and KO(2) and the thiol oxidants diamide and 1-chloro-2,4-dinitrobenzene (CDNB).	Sulfhydryl Compounds	194-199	stress-responsive transcription factor HSF1	Saccharomyces cerevisiae S288C	19-23
17384142-7	2007	Decomposing peroxynitrite with FeTPPs or blocking oxidation using the thiol donor NAC blocked VEGF"s angiogenic functions in vitro and in vivo.	Sulfhydryl Compounds	70-75	vascular endothelial growth factor A	Homo sapiens	94-98
17766407-0	2007	Thiol-based regulation of redox-active glutamate-cysteine ligase from Arabidopsis thaliana.	Sulfhydryl Compounds	0-5	glutamate-cysteine ligase	Arabidopsis thaliana	39-64
17481858-11	2007	Among various antioxidants used in this study, only thiol-containing antioxidants such as NAC or GSH inhibited both JNK and p38 MAPK activation and apoptosis, indicating the unique protective capacity of thiol compounds.	Sulfhydryl Compounds	52-57	mitogen-activated protein kinase 8	Homo sapiens	116-119
17481858-11	2007	Among various antioxidants used in this study, only thiol-containing antioxidants such as NAC or GSH inhibited both JNK and p38 MAPK activation and apoptosis, indicating the unique protective capacity of thiol compounds.	Sulfhydryl Compounds	52-57	mitogen-activated protein kinase 14	Homo sapiens	124-127
17481858-11	2007	Among various antioxidants used in this study, only thiol-containing antioxidants such as NAC or GSH inhibited both JNK and p38 MAPK activation and apoptosis, indicating the unique protective capacity of thiol compounds.	Sulfhydryl Compounds	204-209	mitogen-activated protein kinase 8	Homo sapiens	116-119
17481858-11	2007	Among various antioxidants used in this study, only thiol-containing antioxidants such as NAC or GSH inhibited both JNK and p38 MAPK activation and apoptosis, indicating the unique protective capacity of thiol compounds.	Sulfhydryl Compounds	204-209	mitogen-activated protein kinase 14	Homo sapiens	124-127
17604642-3	2007	The formation of cysteine sulfinic acid (Cys-SO(2)H) and cysteine sulfonic acid (Cys-SO(3)H) has been implicated in the activation of matrix metalloproteinase-7 (MMP-7) and oxidation of thiol to cysteine sulfinic acid has been associated with the autolytic cleavage of MMP-7.	Sulfhydryl Compounds	186-191	matrix metallopeptidase 7	Homo sapiens	134-160
17604642-3	2007	The formation of cysteine sulfinic acid (Cys-SO(2)H) and cysteine sulfonic acid (Cys-SO(3)H) has been implicated in the activation of matrix metalloproteinase-7 (MMP-7) and oxidation of thiol to cysteine sulfinic acid has been associated with the autolytic cleavage of MMP-7.	Sulfhydryl Compounds	186-191	matrix metallopeptidase 7	Homo sapiens	162-167
17766407-8	2007	The thiol-based regulation of GCL provides a posttranslational mechanism for modulating enzyme activity in response to in vivo redox environment and suggests a role for oxidative signaling in the maintenance of glutathione homeostasis in plants.	Sulfhydryl Compounds	4-9	glutamate-cysteine ligase	Arabidopsis thaliana	30-33
17640393-9	2007	The HIV envelope glycoprotein gp120, for example, is regulated by thiol/disulfide exchange and contains allosteric -RHStaple bonds that can exist in the -LHStaple configuration.	Sulfhydryl Compounds	66-71	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	30-35
17602574-10	2007	The unusual {FeNO}7 (S = 1/2) electronic configuration adopted by the substrate-bound iron-nitrosyl CDO (termed {ES-NO}7) is a result of the bidentate thiol/amine coordination of l-cysteine in the NO-bound CDO active site.	Sulfhydryl Compounds	151-156	cysteine dioxygenase 1, cytosolic	Mus musculus	100-103
17602574-10	2007	The unusual {FeNO}7 (S = 1/2) electronic configuration adopted by the substrate-bound iron-nitrosyl CDO (termed {ES-NO}7) is a result of the bidentate thiol/amine coordination of l-cysteine in the NO-bound CDO active site.	Sulfhydryl Compounds	151-156	cysteine dioxygenase 1, cytosolic	Mus musculus	206-209
17540772-11	2007	Thus, we propose that the HRMs in HO-2 constitute a thiol/disulfide redox switch that regulates the myriad physiological functions of HO-2, including its involvement in the hypoxic response in the carotid body, which involves interactions with a Ca(2+)-activated potassium channel.	Sulfhydryl Compounds	52-57	heme oxygenase 2	Homo sapiens	34-38
17540772-11	2007	Thus, we propose that the HRMs in HO-2 constitute a thiol/disulfide redox switch that regulates the myriad physiological functions of HO-2, including its involvement in the hypoxic response in the carotid body, which involves interactions with a Ca(2+)-activated potassium channel.	Sulfhydryl Compounds	52-57	heme oxygenase 2	Homo sapiens	134-138
17414623-4	2007	Thiol compounds such as N-acetyl cysteine, glutathione and dithiothreitol protected the cells against chloroacetaldehyde-induced cell death, although other nonthiol compounds and the antioxidative enzymes superoxide dismutase and catalase did not, suggesting that reactive oxygen species might not mediate cell death.	Sulfhydryl Compounds	0-5	catalase	Homo sapiens	230-238
17585764-3	2007	It is shown that the synthetic thiols having ortho-amide substituents may serve as good models for the enforced proximity of the amide and cysteine thiol groups at the active site of protein tyrosine phosphatase 1B (PTP1B).	Sulfhydryl Compounds	31-37	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	183-214
17585764-3	2007	It is shown that the synthetic thiols having ortho-amide substituents may serve as good models for the enforced proximity of the amide and cysteine thiol groups at the active site of protein tyrosine phosphatase 1B (PTP1B).	Sulfhydryl Compounds	31-37	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	216-221
17603937-8	2007	Compartmental differences from increasing Prx1 show that the redox poise of cytoplasmic and nuclear thiol systems can be dynamically controlled through peroxide elimination.	Sulfhydryl Compounds	100-105	peroxiredoxin 1	Homo sapiens	42-46
17617567-5	2007	The resistance of CD56(bright) cells to oxidative stress was accompanied by a high capacity of neutralizing exogenous hydrogen peroxide, and by a high cell-surface expression of antioxidative thiols.	Sulfhydryl Compounds	192-198	neural cell adhesion molecule 1	Homo sapiens	18-22
17369508-5	2007	Coadministration of alpha-lipoic acid (ALA), a thiol antioxidant, abolished the activation of ASK1 and phosphorylation of downstream kinases, MKK4, and JNK and prevented the down-regulation of DJ-1 and translocation of Daxx to the cytosol seen after MPTP.	Sulfhydryl Compounds	47-52	mitogen-activated protein kinase kinase kinase 5	Mus musculus	94-98
17520482-6	2007	Here we report the membrane topology of yeast Erv29p, which we solved by minimally invasive cysteine accessibility scanning using thiol-specific biotinylation and fluorescent labeling methods.	Sulfhydryl Compounds	130-135	Erv29p	Saccharomyces cerevisiae S288C	46-52
17575178-4	2007	Cysteamine (CS) is a sulfhydryl reducing agent that is known as a depletory agent of somatostatin.	Sulfhydryl Compounds	21-31	somatostatin 1	Gallus gallus	85-97
17566106-4	2007	Adenine nucleotide transport by wild-type AAC2 is inhibited by the sulfhydryl reagent 2-sulfonatoethyl-methanethiosulfonate (MTSES), whereas the activity of a mutant AAC2, devoid of cysteines, is unaffected.	Sulfhydryl Compounds	67-77	ADP/ATP carrier protein PET9	Saccharomyces cerevisiae S288C	42-46
17489560-5	2007	The results herein presented provide the first evidence that cyP with different structures target distinct thiol sites in a protein molecule, namely, H-Ras.	Sulfhydryl Compounds	107-112	HRas proto-oncogene, GTPase	Homo sapiens	150-155
17392378-4	2007	We used perforated patch-clamp technique to analyze the impact of sulfhydryls on H(+)-gated currents from Chinese hamster ovary (CHO) cells expressing human ASIC1a (hASIC1a).	Sulfhydryl Compounds	66-77	acid-sensing (proton-gated) ion channel 1	Mus musculus	157-163
17508907-4	2007	Staining of cellular thiols confirmed that NLS-DAAO-induced ROS selectively modified the nuclear thiol pool, whereas the cytoplasmic pool remained unchanged.	Sulfhydryl Compounds	21-27	D-amino acid oxidase	Homo sapiens	47-51
17508907-4	2007	Staining of cellular thiols confirmed that NLS-DAAO-induced ROS selectively modified the nuclear thiol pool, whereas the cytoplasmic pool remained unchanged.	Sulfhydryl Compounds	21-26	D-amino acid oxidase	Homo sapiens	47-51
17394422-1	2007	IMS (intermembrane space) SOD1 (Cu/Zn-superoxide dismutase) is inactive in isolated intact rat liver mitochondria and is activated following oxidative modification of its critical thiol groups.	Sulfhydryl Compounds	180-185	superoxide dismutase 1	Rattus norvegicus	26-30
17620433-5	2007	To avoid systemic toxicity, we delivered TNF-alpha selectively to the tumor by a gold nanoparticle of 30-nm diameter (CYT-6091) tagged with TNF-alpha and thiol-derivatized polyethylene glycol.	Sulfhydryl Compounds	154-159	tumor necrosis factor	Homo sapiens	41-50
17324568-3	2007	To construct an electrochemical enzyme immunoassay system by using the sensor, the enzyme chemistry of acetylcholinesterase (AChE) to generate a thiol compound was used and combined with the enzyme-linked immunosorbent assays (ELISA).	Sulfhydryl Compounds	145-150	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123
17324568-3	2007	To construct an electrochemical enzyme immunoassay system by using the sensor, the enzyme chemistry of acetylcholinesterase (AChE) to generate a thiol compound was used and combined with the enzyme-linked immunosorbent assays (ELISA).	Sulfhydryl Compounds	145-150	acetylcholinesterase (Cartwright blood group)	Homo sapiens	125-129
17324568-4	2007	After the AChE-catalyzed reaction, the amount of the antigen was obtained by detecting the adsorbing rate of the generated thiol compound on the gold electrode using the FET sensor.	Sulfhydryl Compounds	123-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	10-14
17500523-3	2007	A water soluble RAFT agent was conjugated to a model protein, bovine serum albumin (BSA), via its free thiol group at Cys-34 residue.	Sulfhydryl Compounds	103-108	albumin	Homo sapiens	69-82
17511500-3	2007	Thiol functionalization of heparin carboxylic groups was controlled from 10% to 60% of the available COOH groups, and the retained bioactivity of the modified heparin, characterized by its binding affinity to antithrombin III, decreased with increasing functionalization.	Sulfhydryl Compounds	0-5	serpin family C member 1	Homo sapiens	209-225
17493883-8	2007	Tertiary structural changes as monitored by fluorescence quenching reveal that reduction of disulphide bonds of PSP94 followed by the modification of the free thiol groups leads to complete exposure of Trp32 and Trp92 and that one or more side chain carboxyl groups move closer to their indole side chains.	Sulfhydryl Compounds	159-164	thioredoxin like 1	Homo sapiens	202-207
17567462-2	2007	The antioxidant glutathione (GSH) regulates cell death pathways by modulating the redox state of specific thiol residues of target proteins including transcription factors, stress kinases and caspases, which participate in tumor necrosis factor (TNF)-induced apoptosis.	Sulfhydryl Compounds	106-111	caspase 8	Homo sapiens	192-200
17619801-10	2007	Our study also suggests that MMA(III) could induce the eNOS phosphorylation through modification to cellular thiols of the eNOS enzyme.	Sulfhydryl Compounds	109-115	nitric oxide synthase 3	Homo sapiens	55-59
17619801-10	2007	Our study also suggests that MMA(III) could induce the eNOS phosphorylation through modification to cellular thiols of the eNOS enzyme.	Sulfhydryl Compounds	109-115	nitric oxide synthase 3	Homo sapiens	123-127
17462617-3	2007	Aluminum has been shown to inhibit the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (ALA-D).	Sulfhydryl Compounds	39-49	aminolevulinate dehydratase	Homo sapiens	68-101
17462617-3	2007	Aluminum has been shown to inhibit the sulfhydryl-containing enzyme delta-aminolevulinate dehydratase (ALA-D).	Sulfhydryl Compounds	39-49	aminolevulinate dehydratase	Homo sapiens	103-108
17314138-5	2007	These were mainly due to the peculiar Tellur(IV)-thiol chemistry of the compound, which enabled the compound to interact with cysteine residues on both inflammatory and apoptotic caspases, resulting in their inactivation.	Sulfhydryl Compounds	49-54	caspase 1	Homo sapiens	179-187
17517705-8	2007	Depending on the severity of the heat treatment, lactoferrin aggregates with Cys-containing proteins (beta-lactoglobulin, alpha-lactalbumin, alpha(s2)-casein, and kappa-casein) occurred by intermolecular thiol/disulfide exchange reactions.	Sulfhydryl Compounds	204-209	lactalbumin alpha	Homo sapiens	122-139
17516590-5	2007	The comparison of the reaction of PAO with different thiol reactants revealed the highest binding affinity for ITC followed by thioredoxin and a lower affinity to glutathione.	Sulfhydryl Compounds	53-58	thioredoxin	Homo sapiens	127-138
17567462-2	2007	The antioxidant glutathione (GSH) regulates cell death pathways by modulating the redox state of specific thiol residues of target proteins including transcription factors, stress kinases and caspases, which participate in tumor necrosis factor (TNF)-induced apoptosis.	Sulfhydryl Compounds	106-111	tumor necrosis factor	Homo sapiens	223-244
17567462-2	2007	The antioxidant glutathione (GSH) regulates cell death pathways by modulating the redox state of specific thiol residues of target proteins including transcription factors, stress kinases and caspases, which participate in tumor necrosis factor (TNF)-induced apoptosis.	Sulfhydryl Compounds	106-111	tumor necrosis factor	Homo sapiens	246-249
17459324-2	2007	The inhibition of caspase 3 by singlet oxygen appears to involve the modification of a catalytic cysteine residue, since the reactivity of the sulfhydryl with alkylating agents decreased after singlet oxygen treatment.	Sulfhydryl Compounds	143-153	caspase 3	Homo sapiens	18-27
17317215-10	2007	Furthermore, we describe the thiol modification of the recombinant protein to achieve exact replication of the several prominent post-translationally modified forms of TTR that have been identified in human serum.	Sulfhydryl Compounds	29-34	transthyretin	Homo sapiens	168-171
17416350-0	2007	Glucose regulation of CDK7, a putative thiol related gene, in experimental diabetic nephropathy.	Sulfhydryl Compounds	39-44	cyclin-dependent kinase 7	Rattus norvegicus	22-26
17416350-11	2007	Here we show that CDK7 is a putative thiol related gene which is regulated by glucose in human and rat renal cells.	Sulfhydryl Compounds	37-42	cyclin dependent kinase 7	Homo sapiens	18-22
17368568-3	2007	We investigated these Ca(2+)-dependent changes by probing the cysteine accessibility in wild type and mutant GCAP2 forms with the thiol-modifying reagent 5,5"-dithio-bis-(2-nitrobenzoic acid) (DTNB).	Sulfhydryl Compounds	130-135	guanylate cyclase activator 1B	Homo sapiens	109-114
17171638-6	2007	In affecting the thiol redox status, curcumin caused activation of certain sulfhydryl enzymes involved in signal transduction linked to GADD153 expression.	Sulfhydryl Compounds	17-22	DNA damage inducible transcript 3	Homo sapiens	136-143
17171638-9	2007	Collectively, these findings suggest that a regulatory thiol redox-sensitive signaling cascade exists in the molecular pathway leading to induction of GADD153 expression as caused by curcumin.	Sulfhydryl Compounds	55-60	DNA damage inducible transcript 3	Homo sapiens	151-158
17448893-6	2007	Total thiols and uncoupling protein 2 levels were elevated in the pair-fed Sod1-/- mitochondria, perhaps an adaptive response to oxidant stress.	Sulfhydryl Compounds	6-12	superoxide dismutase 1, soluble	Mus musculus	75-79
17385906-6	2007	An ability of recoverin to form a disulfide dimer and thiol-oxidized monomer under mild oxidizing conditions was found using SDS-PAGE in reducing and nonreducing conditions and Ellman"s test.	Sulfhydryl Compounds	54-59	recoverin	Homo sapiens	14-23
17465884-0	2007	Non-thiol reagents regulate ryanodine receptor function by redox interactions that modify reactive thiols.	Sulfhydryl Compounds	4-9	ryanodine receptor 1	Homo sapiens	28-46
17465884-0	2007	Non-thiol reagents regulate ryanodine receptor function by redox interactions that modify reactive thiols.	Sulfhydryl Compounds	99-105	ryanodine receptor 1	Homo sapiens	28-46
17465884-5	2007	Moreover, channel activators shift the redox potential of reactive thiols on the ryanodine receptor (RyR) to more negative values and decrease the number of reactive thiols, while channel inhibitors shift the redox potential to more positive values and increase the number of reactive thiols.	Sulfhydryl Compounds	67-73	ryanodine receptor 1	Homo sapiens	81-99
17465884-5	2007	Moreover, channel activators shift the redox potential of reactive thiols on the ryanodine receptor (RyR) to more negative values and decrease the number of reactive thiols, while channel inhibitors shift the redox potential to more positive values and increase the number of reactive thiols.	Sulfhydryl Compounds	67-73	ryanodine receptor 1	Homo sapiens	101-104
17465884-5	2007	Moreover, channel activators shift the redox potential of reactive thiols on the ryanodine receptor (RyR) to more negative values and decrease the number of reactive thiols, while channel inhibitors shift the redox potential to more positive values and increase the number of reactive thiols.	Sulfhydryl Compounds	166-172	ryanodine receptor 1	Homo sapiens	81-99
17465884-5	2007	Moreover, channel activators shift the redox potential of reactive thiols on the ryanodine receptor (RyR) to more negative values and decrease the number of reactive thiols, while channel inhibitors shift the redox potential to more positive values and increase the number of reactive thiols.	Sulfhydryl Compounds	166-172	ryanodine receptor 1	Homo sapiens	101-104
17465884-5	2007	Moreover, channel activators shift the redox potential of reactive thiols on the ryanodine receptor (RyR) to more negative values and decrease the number of reactive thiols, while channel inhibitors shift the redox potential to more positive values and increase the number of reactive thiols.	Sulfhydryl Compounds	166-172	ryanodine receptor 1	Homo sapiens	81-99
17465884-5	2007	Moreover, channel activators shift the redox potential of reactive thiols on the ryanodine receptor (RyR) to more negative values and decrease the number of reactive thiols, while channel inhibitors shift the redox potential to more positive values and increase the number of reactive thiols.	Sulfhydryl Compounds	166-172	ryanodine receptor 1	Homo sapiens	101-104
17514531-1	2007	Glutathione reductase (GR) plays a key role in maintaining thiol groups in the lens, and its activity decreases with aging and cataract formation.	Sulfhydryl Compounds	59-64	glutathione-disulfide reductase	Homo sapiens	0-21
17514531-1	2007	Glutathione reductase (GR) plays a key role in maintaining thiol groups in the lens, and its activity decreases with aging and cataract formation.	Sulfhydryl Compounds	59-64	glutathione-disulfide reductase	Homo sapiens	23-25
17514531-4	2007	Thioltransferase (TTase, or glutaredoxin) can maintain the homeostasis of lens protein thiols thus protecting against oxidative stress.	Sulfhydryl Compounds	87-93	glutaredoxin	Homo sapiens	0-16
17514531-4	2007	Thioltransferase (TTase, or glutaredoxin) can maintain the homeostasis of lens protein thiols thus protecting against oxidative stress.	Sulfhydryl Compounds	87-93	glutaredoxin	Homo sapiens	18-23
17514531-4	2007	Thioltransferase (TTase, or glutaredoxin) can maintain the homeostasis of lens protein thiols thus protecting against oxidative stress.	Sulfhydryl Compounds	87-93	glutaredoxin	Homo sapiens	28-40
17385906-5	2007	Spectrophotometric titration of Ca2+-loaded recoverin gave 7.6 for the pKa value of Cys38 thiol, suggesting partial deprotonation of the thiol in vivo conditions.	Sulfhydryl Compounds	90-95	recoverin	Homo sapiens	44-53
17385906-5	2007	Spectrophotometric titration of Ca2+-loaded recoverin gave 7.6 for the pKa value of Cys38 thiol, suggesting partial deprotonation of the thiol in vivo conditions.	Sulfhydryl Compounds	137-142	recoverin	Homo sapiens	44-53
17030421-7	2007	For Cd-cysteine complexes EXAFS data agree with the existence of Cd-S clusters, thus suggesting a predominant role of the thiol group in the bonding of Cd with the amino acid.	Sulfhydryl Compounds	122-127	CDP-diacylglycerol synthase 1	Homo sapiens	65-69
17385906-9	2007	The Ca2+ modulated susceptibility of the recoverin thiol to reversible oxidation may be of potential importance for functioning of recoverin in photoreceptor cells.	Sulfhydryl Compounds	51-56	recoverin	Homo sapiens	41-50
17385906-9	2007	The Ca2+ modulated susceptibility of the recoverin thiol to reversible oxidation may be of potential importance for functioning of recoverin in photoreceptor cells.	Sulfhydryl Compounds	51-56	recoverin	Homo sapiens	131-140
17208454-0	2007	Cox17, a copper chaperone for cytochrome c oxidase: expression, purification, and formation of mixed disulphide adducts with thiol reagents.	Sulfhydryl Compounds	125-130	cytochrome c oxidase copper chaperone COX17	Homo sapiens	0-5
17353260-0	2007	Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention.	Sulfhydryl Compounds	88-93	adiponectin, C1Q and collagen domain containing	Homo sapiens	54-65
17353260-6	2007	Here, we show that there is an abundant pool of properly folded adiponectin in the secretory pathway that is retained through thiol-mediated retention, as judged by the release of adiponectin in response to treatment of adipocytes with reducing agents.	Sulfhydryl Compounds	126-131	adiponectin, C1Q and collagen domain containing	Homo sapiens	64-75
17353260-6	2007	Here, we show that there is an abundant pool of properly folded adiponectin in the secretory pathway that is retained through thiol-mediated retention, as judged by the release of adiponectin in response to treatment of adipocytes with reducing agents.	Sulfhydryl Compounds	126-131	adiponectin, C1Q and collagen domain containing	Homo sapiens	180-191
17182074-4	2007	To find out whether His8 in the conserved SPHQ sequence of Env directs thiol activation, we analyzed its ionization in MLV vectors with wtEnv and Env with His8 deleted or substituted for Tyr or Arg, which partially or completely arrests fusion.	Sulfhydryl Compounds	71-76	endogenous retrovirus group W member 1, envelope	Homo sapiens	59-62
17417949-5	2007	To increase cell survival, arginine-glycine-aspartic acid-serine (RGDS) was incorporated into gels using a novel mixed-mode thiol-ene reaction by synthesizing a cysteine-cysteine-arginine-glycine-aspartic acid-serine-cysteine-cysteine-glycine, N-terminus to C-terminus peptide sequence with pendant cysteine residues.	Sulfhydryl Compounds	124-129	ral guanine nucleotide dissociation stimulator	Homo sapiens	66-70
17452434-1	2007	Antigen-binding fragments (Fab") of antibodies can be site specifically PEGylated at thiols using cysteine reactive PEG-maleimide conjugates.	Sulfhydryl Compounds	85-91	FA complementation group B	Homo sapiens	27-30
17452434-1	2007	Antigen-binding fragments (Fab") of antibodies can be site specifically PEGylated at thiols using cysteine reactive PEG-maleimide conjugates.	Sulfhydryl Compounds	85-91	progestagen associated endometrial protein	Homo sapiens	72-75
17452434-7	2007	The use of the non-thiol reductant tris(2-carboxyethyl) phosphine combined with protein engineering enables us to demonstrate the mono-, di- and tri-PEGylation of Fab fragments with a range of PEG size.	Sulfhydryl Compounds	19-24	FA complementation group B	Homo sapiens	163-166
17452434-7	2007	The use of the non-thiol reductant tris(2-carboxyethyl) phosphine combined with protein engineering enables us to demonstrate the mono-, di- and tri-PEGylation of Fab fragments with a range of PEG size.	Sulfhydryl Compounds	19-24	progestagen associated endometrial protein	Homo sapiens	149-152
17046138-3	2007	Continuous hydrolysis of S(P)-CHMPTCh was measured spectrophotometrically from thiocholine released during hydrolysis with DTNB as the thiol reagent.	Sulfhydryl Compounds	135-140	dystrobrevin, beta	Mus musculus	123-127
17448375-8	2007	In CV-, oxidative stress of RyR (reduction in the number of free thiols) was severe, but it was negligible in CV+.	Sulfhydryl Compounds	65-71	ryanodine receptor 1	Homo sapiens	28-31
17254730-3	2007	The cTnT receptor molecule was covalently immobilized on a gold substrate via a self-assembled monolayer (SAM) of thiols by using cysteamine-coupling chemistry.	Sulfhydryl Compounds	114-120	troponin T2, cardiac type	Homo sapiens	4-8
17329258-0	2007	The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents.	Sulfhydryl Compounds	110-115	peroxiredoxin 2	Homo sapiens	23-38
17329258-1	2007	Peroxiredoxin 2 is a member of the mammalian peroxiredoxin family of thiol proteins that is important in antioxidant defense and redox signaling.	Sulfhydryl Compounds	69-74	peroxiredoxin 2	Homo sapiens	0-15
17329258-13	2007	These results demonstrate that peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents.	Sulfhydryl Compounds	117-122	peroxiredoxin 2	Homo sapiens	31-46
17329258-13	2007	These results demonstrate that peroxiredoxin 2 has a tertiary structure that facilitates reaction of the active site thiol with hydrogen peroxide while restricting its reactivity with other thiol reagents.	Sulfhydryl Compounds	190-195	peroxiredoxin 2	Homo sapiens	31-46
17289381-0	2007	Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.	Sulfhydryl Compounds	6-11	ADAM metallopeptidase domain 17	Homo sapiens	18-22
17289381-0	2007	Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.	Sulfhydryl Compounds	6-11	sarcosine dehydrogenase	Homo sapiens	67-70
17289381-0	2007	Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.	Sulfhydryl Compounds	74-79	ADAM metallopeptidase domain 17	Homo sapiens	18-22
17289381-0	2007	Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.	Sulfhydryl Compounds	74-79	sarcosine dehydrogenase	Homo sapiens	67-70
17289381-1	2007	A series of potent thiol-containing aryl sulfonamide TACE inhibitors was designed and synthesized.	Sulfhydryl Compounds	19-24	ADAM metallopeptidase domain 17	Homo sapiens	53-57
17376285-8	2007	Redox-sensitive transcription factors such as nuclear factor-E2-related factor 2 (Nrf2), AP-1, NF-kappaB, to cite a few examples, sense and transduce changes in the cellular redox status and modulate gene expression responses to oxidative and electrophilic stresses, presumably via sulfhydryl modification of critical cysteine residues found on these proteins and/or other upstream redox-sensitive molecular targets.	Sulfhydryl Compounds	282-292	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
17303331-0	2007	The thiol antioxidant 1,2-dithiole-3-thione stimulates the expression of heat shock protein 70 in dopaminergic PC12 cells.	Sulfhydryl Compounds	4-9	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	73-94
17270303-3	2007	Topical iodine protects the dermally applied insulin presumably by inactivation of endogenous sulfhydryls such as glutathione and gamma glutamylcysteine which can reduce the disulfide bonds of the hormone.	Sulfhydryl Compounds	94-105	insulin	Homo sapiens	45-52
17376285-8	2007	Redox-sensitive transcription factors such as nuclear factor-E2-related factor 2 (Nrf2), AP-1, NF-kappaB, to cite a few examples, sense and transduce changes in the cellular redox status and modulate gene expression responses to oxidative and electrophilic stresses, presumably via sulfhydryl modification of critical cysteine residues found on these proteins and/or other upstream redox-sensitive molecular targets.	Sulfhydryl Compounds	282-292	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-93
17320038-5	2007	In comparison to wild-type mPrP(23-231), N-mPrP(3SS) exhibits an indistinguishable CD spectra, a similar conformational stability in the absence of thiol and a reduced ability to aggregate.	Sulfhydryl Compounds	148-153	prion protein	Mus musculus	43-47
17320038-6	2007	In the presence of thiol catalyst and denaturant, N-mPrP(3SS) unfolds and generates diverse isomers that are amenable to further isolation, structural and functional analysis.	Sulfhydryl Compounds	19-24	prion protein	Mus musculus	52-56
17430122-6	2007	While the molecular events responsible for the salutary effects of ethyl pyruvate remain to be elucidated, one mechanism may involve covalent modification of a critical thiol residue in the p65 component of NF-kappaB.	Sulfhydryl Compounds	169-174	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	207-216
17349926-4	2007	More recently, LPO has been shown to oxidize a wide diversity of thiol compounds to thiyl free radicals, which ultimately lead to the formation of a protein radical characterized by DMPO-immunospin trapping.	Sulfhydryl Compounds	65-70	lactoperoxidase	Homo sapiens	15-18
17315258-7	2007	Finally, the effects of thiol-reactive reagents such as N-ethylmaleimide (NEM) and nitric oxide donors on DLDH diaphorase activity were evaluated, demonstrating that, with this method, DLDH diaphorase activity can be determined without having to remove these thiol-reactive reagents that may otherwise interfere with spectrophotometric measurement of DLDH dehydrogenase activity.	Sulfhydryl Compounds	24-29	dihydrolipoamide dehydrogenase	Homo sapiens	106-110
17315258-7	2007	Finally, the effects of thiol-reactive reagents such as N-ethylmaleimide (NEM) and nitric oxide donors on DLDH diaphorase activity were evaluated, demonstrating that, with this method, DLDH diaphorase activity can be determined without having to remove these thiol-reactive reagents that may otherwise interfere with spectrophotometric measurement of DLDH dehydrogenase activity.	Sulfhydryl Compounds	24-29	dihydrolipoamide dehydrogenase	Homo sapiens	185-189
17315258-7	2007	Finally, the effects of thiol-reactive reagents such as N-ethylmaleimide (NEM) and nitric oxide donors on DLDH diaphorase activity were evaluated, demonstrating that, with this method, DLDH diaphorase activity can be determined without having to remove these thiol-reactive reagents that may otherwise interfere with spectrophotometric measurement of DLDH dehydrogenase activity.	Sulfhydryl Compounds	24-29	dihydrolipoamide dehydrogenase	Homo sapiens	185-189
17315258-7	2007	Finally, the effects of thiol-reactive reagents such as N-ethylmaleimide (NEM) and nitric oxide donors on DLDH diaphorase activity were evaluated, demonstrating that, with this method, DLDH diaphorase activity can be determined without having to remove these thiol-reactive reagents that may otherwise interfere with spectrophotometric measurement of DLDH dehydrogenase activity.	Sulfhydryl Compounds	259-264	dihydrolipoamide dehydrogenase	Homo sapiens	185-189
17315258-7	2007	Finally, the effects of thiol-reactive reagents such as N-ethylmaleimide (NEM) and nitric oxide donors on DLDH diaphorase activity were evaluated, demonstrating that, with this method, DLDH diaphorase activity can be determined without having to remove these thiol-reactive reagents that may otherwise interfere with spectrophotometric measurement of DLDH dehydrogenase activity.	Sulfhydryl Compounds	259-264	dihydrolipoamide dehydrogenase	Homo sapiens	185-189
17624240-7	2007	When TBL are protected from apoptosis by the thiol molecule N-acetyl-L-cysteine (NAC), there is no longer any increase in glycohydrolase activities and mRNA expression of beta-hexosaminidase alpha- and beta-subunits.	Sulfhydryl Compounds	45-50	X-linked Kx blood group	Homo sapiens	81-84
17388698-0	2007	Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha.	Sulfhydryl Compounds	91-96	superoxide dismutase 2	Homo sapiens	0-30
17388698-0	2007	Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha.	Sulfhydryl Compounds	91-96	superoxide dismutase 2	Homo sapiens	32-36
17084061-4	2007	To investigate the mechanisms by which these compounds inhibit human blood delta-ALA-D activity, a thiol reducing agent or zinc chloride were used.	Sulfhydryl Compounds	99-104	aminolevulinate dehydratase	Homo sapiens	75-86
17298084-8	2007	In contrast to QSOX, Erv2p shows a comparatively low turnover with a range of small thiol substrates, with reduced Escherichia coli thioredoxin and with unfolded proteins.	Sulfhydryl Compounds	84-89	flavin-linked sulfhydryl oxidase	Saccharomyces cerevisiae S288C	21-26
17237236-5	2007	Co-immunoprecipitation experiments demonstrated a physical interaction between JP1 and RyR1 that, like thiol reactivity, was sensitive to RyR1 conformation and chemical status of the hyper-reactive cysteines of JP1 and RyR1.	Sulfhydryl Compounds	103-108	junctophilin 1	Homo sapiens	79-82
17237236-5	2007	Co-immunoprecipitation experiments demonstrated a physical interaction between JP1 and RyR1 that, like thiol reactivity, was sensitive to RyR1 conformation and chemical status of the hyper-reactive cysteines of JP1 and RyR1.	Sulfhydryl Compounds	103-108	ryanodine receptor 1	Homo sapiens	87-91
17237236-0	2007	Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.	Sulfhydryl Compounds	146-152	junctophilin 1	Homo sapiens	36-50
17237236-0	2007	Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.	Sulfhydryl Compounds	146-152	junctophilin 1	Homo sapiens	52-55
17237236-0	2007	Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.	Sulfhydryl Compounds	146-152	ryanodine receptor 1	Homo sapiens	61-86
17237236-0	2007	Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyR1) channel complex is mediated by their hyper-reactive thiols.	Sulfhydryl Compounds	146-152	ryanodine receptor 1	Homo sapiens	88-92
17237236-3	2007	The reactivity of these thiol groups was very sensitive to oxidation by naphthoquinone, H2O2, NO, or O2, all known modulators of the RyR1 channel complex.	Sulfhydryl Compounds	24-29	ryanodine receptor 1	Homo sapiens	133-137
17207453-2	2007	Sublethal dose of AAP resulted in a decrease in microsomal total glutathione and in the reduced-to-total glutathione ratio; redox state of thiols of ER resident oxidoreductases ERp72, PDI was shifted towards the oxidized form; ER stress-responsive transcription factor ATF6 was activated.	Sulfhydryl Compounds	139-145	protein disulfide isomerase associated 4	Mus musculus	177-182
17320913-15	2007	Hence, our present findings indicate that chalcone suppresses both IL-6- and LPS-induced signaling pathways through the thiol-dependent intracellular redox state.	Sulfhydryl Compounds	120-125	interleukin 6	Homo sapiens	67-71
17405690-1	2007	Mercury, cadmium, and other heavy metals have a high affinity for sulfhydryl (-SH) groups, inactivating numerous enzymatic reactions, amino acids, and sulfur-containing antioxidants (NAC, ALA, GSH), with subsequent decreased oxidant defense and increased oxidative stress.	Sulfhydryl Compounds	66-76	synuclein alpha	Homo sapiens	183-186
17320764-0	2007	Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry.	Sulfhydryl Compounds	72-78	HRas proto-oncogene, GTPase	Homo sapiens	82-88
17320764-2	2007	Posttranslational modification of reactive thiols, by reversible S-glutathiolation and S-nitrosation, and potentially also by irreversible oxidation, may have significant effects on p21ras activity.	Sulfhydryl Compounds	43-49	HRas proto-oncogene, GTPase	Homo sapiens	182-188
17320764-3	2007	Here we used an isotope-coded affinity tag (ICAT) and mass spectrometry to quantitate the reversible and irreversible oxidative posttranslational thiol modifications of p21ras caused by peroxynitrite (ONOO(-)) or glutathione disulfide (GSSG).	Sulfhydryl Compounds	146-151	HRas proto-oncogene, GTPase	Homo sapiens	169-175
17320764-8	2007	The quantitative changes in thiol modification caused by GSSG associated with increased activity demonstrate the potential importance of redox modulation of p21ras.	Sulfhydryl Compounds	28-33	HRas proto-oncogene, GTPase	Homo sapiens	157-163
17326604-1	2007	We have utilized protective oligonucleotides to modify DNA fragments with osmium tetroxide complexes without compromising their ability to hybridize with immobilized thiol-linked probe-SAMs on gold electrodes.	Sulfhydryl Compounds	166-171	methionine adenosyltransferase 1A	Homo sapiens	185-189
17172268-0	2007	Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	30-41
17172268-0	2007	Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system.	Sulfhydryl Compounds	0-5	glutaredoxin	Homo sapiens	46-58
17325184-6	2007	SDS-PAGE and size exclusion chromatography were performed to analyze the structural changes of S100B after oxidation of its thiol groups under denaturing and nondenaturing conditions, respectively.	Sulfhydryl Compounds	124-129	S100 calcium binding protein B	Homo sapiens	95-100
17161827-4	2007	The ELP-based doxorubicin delivery vehicle (Tat-ELP-GFLG-Dox) consists of: (1) a peptide derived from the HIV-1 Tat protein to facilitate its cellular uptake, (2) ELP to allow thermal targeting, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) spacer and a cysteine residue conjugated to a thiol reactive doxorubicin derivative.	Sulfhydryl Compounds	315-320	nuclear receptor subfamily 5 group A member 1	Homo sapiens	4-7
17189688-1	2007	A novel series of cyclic potent, selective, small molecule, thiol-based inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) and the crystal structures of TAFIa inhibitors bound to porcine pancreatic carboxypeptidase B are described.	Sulfhydryl Compounds	60-65	coagulation factor II, thrombin	Homo sapiens	96-104
17325184-13	2007	Oxidation of S100B"s thiol groups resulted in the formation of oligomers that displayed distinct RAGE biological activity compared with the simple dimeric form.	Sulfhydryl Compounds	21-26	S100 calcium binding protein B	Homo sapiens	13-18
17325184-13	2007	Oxidation of S100B"s thiol groups resulted in the formation of oligomers that displayed distinct RAGE biological activity compared with the simple dimeric form.	Sulfhydryl Compounds	21-26	long intergenic non-protein coding RNA 914	Homo sapiens	97-101
17593728-2	2007	Experimental results demonstrate that complexation of Fe(II) by catechol- and thiol-containing organic ligands leads to formation of highly reactive species that reduce RDX (hexahydro-1,3,5-trinitro-1,3,5-triazine) and related N-heterocyclic nitramine explosive compounds to formaldehyde and inorganic nitrogen byproducts.	Sulfhydryl Compounds	78-83	radixin	Homo sapiens	169-172
17335514-10	2007	Compared with wild type, the total thiol levels in ars4, ars5 and ars4ars5 mutants were increased up to 80% with combined buthionine sulfoximine and arsenic treatments, suggesting the enhancement of mechanisms that mediate thiol synthesis in the mutants.	Sulfhydryl Compounds	35-40	proteasome alpha subunit F1	Arabidopsis thaliana	57-61
17335514-10	2007	Compared with wild type, the total thiol levels in ars4, ars5 and ars4ars5 mutants were increased up to 80% with combined buthionine sulfoximine and arsenic treatments, suggesting the enhancement of mechanisms that mediate thiol synthesis in the mutants.	Sulfhydryl Compounds	35-40	proteasome alpha subunit F1	Arabidopsis thaliana	66-74
17335514-10	2007	Compared with wild type, the total thiol levels in ars4, ars5 and ars4ars5 mutants were increased up to 80% with combined buthionine sulfoximine and arsenic treatments, suggesting the enhancement of mechanisms that mediate thiol synthesis in the mutants.	Sulfhydryl Compounds	223-228	proteasome alpha subunit F1	Arabidopsis thaliana	57-61
17335514-10	2007	Compared with wild type, the total thiol levels in ars4, ars5 and ars4ars5 mutants were increased up to 80% with combined buthionine sulfoximine and arsenic treatments, suggesting the enhancement of mechanisms that mediate thiol synthesis in the mutants.	Sulfhydryl Compounds	223-228	proteasome alpha subunit F1	Arabidopsis thaliana	66-74
17335514-11	2007	The presented findings show that PHYA negatively regulates a pathway conferring arsenic tolerance, and that an enhanced thiol synthesis mechanism contributes to the arsenic tolerance of ars4ars5.	Sulfhydryl Compounds	120-125	proteasome alpha subunit F1	Arabidopsis thaliana	186-194
17259326-4	2007	Cystamine, which inactivates TG2 activity by forming a mixed disulfide, may interfere with and inhibit other thiol-dependent enzymes such as caspases.	Sulfhydryl Compounds	109-114	transglutaminase 2, C polypeptide	Mus musculus	29-32
17222828-4	2007	Our findings indicate that inhibition of caspase-8 by thiol-reactive agents such as acrolein is not due to GSH depletion but caused by direct protein thiol modifications.	Sulfhydryl Compounds	54-59	caspase 8	Homo sapiens	41-50
17222828-4	2007	Our findings indicate that inhibition of caspase-8 by thiol-reactive agents such as acrolein is not due to GSH depletion but caused by direct protein thiol modifications.	Sulfhydryl Compounds	150-155	caspase 8	Homo sapiens	41-50
17141888-0	2007	The effects of modulation of gamma-glutamyl transpeptidase activity in HepG2 cells on thiol homeostasis and caspase-3-activity.	Sulfhydryl Compounds	86-91	inactive glutathione hydrolase 2	Homo sapiens	29-58
17141888-1	2007	The present studies aimed to elucidate how the modulation of gamma-glutamyl transpeptidase (gammaGT) activity in human hepatoma (HepG2) cell line influences H(2)O(2) production, caspase 3 activity, protein S-thiolation by glutathione (GSH), cysteinyl-glycine (Cys-Gly) and cysteine (Cys), and the level of other redox forms of these thiols.	Sulfhydryl Compounds	333-339	inactive glutathione hydrolase 2	Homo sapiens	61-90
17141888-1	2007	The present studies aimed to elucidate how the modulation of gamma-glutamyl transpeptidase (gammaGT) activity in human hepatoma (HepG2) cell line influences H(2)O(2) production, caspase 3 activity, protein S-thiolation by glutathione (GSH), cysteinyl-glycine (Cys-Gly) and cysteine (Cys), and the level of other redox forms of these thiols.	Sulfhydryl Compounds	333-339	inactive glutathione hydrolase 2	Homo sapiens	92-99
17074504-0	2007	Identification of redox sensitive thiols of protein disulfide isomerase using isotope coded affinity technology and mass spectrometry.	Sulfhydryl Compounds	34-40	prolyl 4-hydroxylase subunit beta	Homo sapiens	44-71
17074504-2	2007	Here we describe a procedure utilizing isotope-coded affinity tag (ICAT) technology and mass spectrometry that quantitates relative changes in the dynamic thiol and disulfide states of human PDI.	Sulfhydryl Compounds	155-160	prolyl 4-hydroxylase subunit beta	Homo sapiens	191-194
17235131-6	2007	Cross-linking the free thiol groups of beta-LG by heating (100 degrees C for 2 min), or chemically modifying the beta-LG by carboxymethylation to block the thiol groups resulted in a substantial loss of antioxidant activity.	Sulfhydryl Compounds	156-161	beta-lactoglobulin	Bos taurus	113-120
16990041-2	2007	Incubation of GSNO or albSNO (1 microM) with the megakaryocyte cell line MEG-01 resulted in a cell-mediated removal of each compound which was inhibited by blocking cell surface thiols with 5,5"-dithiobis 2-nitrobenzoic acid (DTNB) (100 microM) or inhibiting PDI with bacitracin (5mM).	Sulfhydryl Compounds	178-184	prolyl 4-hydroxylase subunit beta	Homo sapiens	259-262
17235131-6	2007	Cross-linking the free thiol groups of beta-LG by heating (100 degrees C for 2 min), or chemically modifying the beta-LG by carboxymethylation to block the thiol groups resulted in a substantial loss of antioxidant activity.	Sulfhydryl Compounds	23-28	beta-lactoglobulin	Bos taurus	39-46
17235131-6	2007	Cross-linking the free thiol groups of beta-LG by heating (100 degrees C for 2 min), or chemically modifying the beta-LG by carboxymethylation to block the thiol groups resulted in a substantial loss of antioxidant activity.	Sulfhydryl Compounds	156-161	beta-lactoglobulin	Bos taurus	39-46
17308047-2	2007	In the present study, a novel amonafide analogue, 2-(2-dimethylamino)-6-thia-2-aza-benzo-[def]-chrysene-1,3-diones (R16) was synthesized by substituting 5"-NH(2) of the naphthyl with a heterocyclic group to amonafide, with additional introduction of a thiol group.	Sulfhydryl Compounds	252-257	solute carrier family 1 member 5	Homo sapiens	116-119
17578111-2	2007	Within the working distance in the dynamic force mode AFM, the thiol showed strong interactions bridging between a gold-coated probe tip and a gold-coated Si substrate, resulting in unstable amplitude and noisy AFM images.	Sulfhydryl Compounds	63-68	TOR signaling pathway regulator	Homo sapiens	133-136
16990041-8	2007	Immunoprecipitation experiments showed that GSNO caused a concentration-dependent loss of thiol reactivity of PDI.	Sulfhydryl Compounds	90-95	prolyl 4-hydroxylase subunit beta	Homo sapiens	110-113
16990041-9	2007	Our data indicate that PDI is involved in both rapid metabolism of GSNO and intracellular NO delivery and that during this process PDI is itself altered by thiol modification.	Sulfhydryl Compounds	156-161	prolyl 4-hydroxylase subunit beta	Homo sapiens	23-26
16990041-9	2007	Our data indicate that PDI is involved in both rapid metabolism of GSNO and intracellular NO delivery and that during this process PDI is itself altered by thiol modification.	Sulfhydryl Compounds	156-161	prolyl 4-hydroxylase subunit beta	Homo sapiens	131-134
17520089-6	2007	The data indicated that in the course of hPAP denaturation exposure of thiol groups to reagents took place faster than the enzyme inactivation and exposure of the protein hydrophobic surface.	Sulfhydryl Compounds	71-76	PDGFA associated protein 1	Homo sapiens	41-45
17166480-6	2007	However, this thiol compound was efficiently oxidized by the apocynin radical during the MPO-catalyzed oxidation.	Sulfhydryl Compounds	14-19	myeloperoxidase	Homo sapiens	89-92
17169324-6	2007	Covalent interactions also occur in cells, in which 15d-PGJ2 binds to endogenous GSTP1-1, irreversibly reduces GST free-thiol content and inhibits GST activity.	Sulfhydryl Compounds	120-125	glutathione S-transferase pi 1	Homo sapiens	81-88
17189831-6	2007	Incubation with the thiol antioxidant N-acetylcysteine strongly inhibited both the Nrf2 accumulation and the expression of Nrf2-regulated genes such as HO-1, GCLM, and SQSTM1.	Sulfhydryl Compounds	20-25	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
17189831-6	2007	Incubation with the thiol antioxidant N-acetylcysteine strongly inhibited both the Nrf2 accumulation and the expression of Nrf2-regulated genes such as HO-1, GCLM, and SQSTM1.	Sulfhydryl Compounds	20-25	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
17189831-6	2007	Incubation with the thiol antioxidant N-acetylcysteine strongly inhibited both the Nrf2 accumulation and the expression of Nrf2-regulated genes such as HO-1, GCLM, and SQSTM1.	Sulfhydryl Compounds	20-25	heme oxygenase 1	Homo sapiens	152-156
17189831-6	2007	Incubation with the thiol antioxidant N-acetylcysteine strongly inhibited both the Nrf2 accumulation and the expression of Nrf2-regulated genes such as HO-1, GCLM, and SQSTM1.	Sulfhydryl Compounds	20-25	glutamate-cysteine ligase modifier subunit	Homo sapiens	158-162
17189831-6	2007	Incubation with the thiol antioxidant N-acetylcysteine strongly inhibited both the Nrf2 accumulation and the expression of Nrf2-regulated genes such as HO-1, GCLM, and SQSTM1.	Sulfhydryl Compounds	20-25	sequestosome 1	Homo sapiens	168-174
17126812-5	2007	Lack of methionine sulfoxide reductase A (MsrA) in liver of MsrA-/- led to a significant drop in the cellular level of thiol groups and lowered the CDO level of expression.	Sulfhydryl Compounds	119-124	methionine sulfoxide reductase A	Homo sapiens	8-40
17126812-5	2007	Lack of methionine sulfoxide reductase A (MsrA) in liver of MsrA-/- led to a significant drop in the cellular level of thiol groups and lowered the CDO level of expression.	Sulfhydryl Compounds	119-124	methionine sulfoxide reductase A	Homo sapiens	42-46
17126812-5	2007	Lack of methionine sulfoxide reductase A (MsrA) in liver of MsrA-/- led to a significant drop in the cellular level of thiol groups and lowered the CDO level of expression.	Sulfhydryl Compounds	119-124	methionine sulfoxide reductase A	Homo sapiens	60-64
17196530-1	2007	Under ambient air conditions, NO inhibits NMDAR activity by reacting with the NR2A subunit C399 along with two additional cysteine pairs if their disulfide bonds are reduced to free thiol groups [NR1(C744,C798); NR2(C87,C320)].	Sulfhydryl Compounds	182-187	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	196-199
17182746-8	2007	The pathogenic mutation therefore could (i) lessen the Sco1 affinity for copper(I) and hence copper supply for CcO or (ii) decrease the efficiency of reduction of CcO thiols involved in copper binding, or both effects could be produced by the mutation.	Sulfhydryl Compounds	167-173	synthesis of cytochrome C oxidase 1	Homo sapiens	55-59
17198380-1	2007	Design of a partially cysteine-depleted C98S/C239S/C377S/C468A cytochrome P450 3A4 mutant designated CYP3A4(C58,C64) allowed site-directed incorporation of thiol-reactive fluorescent probes into alpha-helix A.	Sulfhydryl Compounds	156-161	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-82
17198380-1	2007	Design of a partially cysteine-depleted C98S/C239S/C377S/C468A cytochrome P450 3A4 mutant designated CYP3A4(C58,C64) allowed site-directed incorporation of thiol-reactive fluorescent probes into alpha-helix A.	Sulfhydryl Compounds	156-161	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-107
17121405-0	2007	Functional immobilization of the small GTPase Rab6A on DNA-Gold nanoparticles by using a site-specifically attached poly(ethylene glycol) linker and thiol place-exchange reaction.	Sulfhydryl Compounds	149-154	RAB6A, member RAS oncogene family	Homo sapiens	46-51
17115886-1	2007	Thioredoxin and glutaredoxin systems in mammalian cells utilize thiol and selenol groups to maintain a reducing intracellular redox state acting as antioxidants and reducing agents in redox signaling with oxidizing reactive oxygen species.	Sulfhydryl Compounds	64-69	thioredoxin	Homo sapiens	0-11
17691219-0	2007	Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer"s and Parkinson"s diseases.	Sulfhydryl Compounds	34-40	methylenetetrahydrofolate reductase	Homo sapiens	72-77
17691219-0	2007	Oxidative DNA damage and level of thiols as related to polymorphisms of MTHFR, MTR, MTHFD1 in Alzheimer"s and Parkinson"s diseases.	Sulfhydryl Compounds	34-40	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	84-90
17691219-6	2007	The results indicate that of the enzymes studied only polymorphisms of folate-dependent enzyme MTHFD1 have pointed to significant differences in intensity of turnover of circulating thiols between AD and PD patients.	Sulfhydryl Compounds	182-188	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	95-101
17115894-3	2007	The authors have demonstrated that the iron-sulfur cluster is complexed by the two N-terminal active site thiols of two Grx2 monomers and two molecules of glutathione that are bound noncovalently to the proteins and in equilibrium with glutathione in solution.	Sulfhydryl Compounds	106-112	glutaredoxin 2	Homo sapiens	120-124
17115886-1	2007	Thioredoxin and glutaredoxin systems in mammalian cells utilize thiol and selenol groups to maintain a reducing intracellular redox state acting as antioxidants and reducing agents in redox signaling with oxidizing reactive oxygen species.	Sulfhydryl Compounds	64-69	glutaredoxin	Homo sapiens	16-28
17189203-7	2007	These results suggest a mitochondrial pathway for the regulation of cellular copper content that involves signaling through SCO1 and SCO2, perhaps by their thiol redox or metal-binding state.	Sulfhydryl Compounds	156-161	synthesis of cytochrome C oxidase 1	Homo sapiens	124-128
17068286-0	2007	Thiol-related genes in diabetic complications: a novel protective role for endogenous thioredoxin 2.	Sulfhydryl Compounds	0-5	thioredoxin 2	Rattus norvegicus	86-99
17068286-9	2007	CONCLUSIONS: These results provided the first expression profile of thiol-related genes in a model of diabetes and demonstrated a novel role for endogenous thioredoxin 2 in protecting cells against high ambient glucose.	Sulfhydryl Compounds	68-73	thioredoxin 2	Rattus norvegicus	156-169
17189203-7	2007	These results suggest a mitochondrial pathway for the regulation of cellular copper content that involves signaling through SCO1 and SCO2, perhaps by their thiol redox or metal-binding state.	Sulfhydryl Compounds	156-161	synthesis of cytochrome C oxidase 2	Homo sapiens	133-137
17380793-5	2007	While the molecular events responsible for the salutary effects of EP remain to be elucidated, one mechanism may involve covalent modification of a critical thiol residue in the p65 component of NF-kappaB.	Sulfhydryl Compounds	157-162	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-204
17226937-6	2007	In the proposed reaction mechanism, the active-site cysteine residue of GSTO1-1 reacts with the S-(phenacyl)glutathione substrate to give an acetophenone and a mixed disulfide with the active-site cysteine; a second thiol substrate (e.g., glutathione or 2-mercaptoethanol) reacts with the active-site disulfide to regenerate the catalytically active enzyme and to form a mixed disulfide.	Sulfhydryl Compounds	216-221	glutathione S-transferase omega 1	Rattus norvegicus	72-79
17506717-2	2007	In the early 1990"s, it was demonstrated that experimental radiation nephropathy could be treated with a thiol-containing ACE inhibitor, captopril.	Sulfhydryl Compounds	105-110	angiotensin I converting enzyme	Homo sapiens	122-125
17365148-0	2007	Mercury activates vascular endothelial cell phospholipase D through thiols and oxidative stress.	Sulfhydryl Compounds	68-74	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	44-59
17365148-6	2007	Sulfhydryl (thiol-protective) agents and antioxidants also significantly attenuated the mercury-induced PLD activation in BPAECs.	Sulfhydryl Compounds	0-10	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	104-107
17365148-6	2007	Sulfhydryl (thiol-protective) agents and antioxidants also significantly attenuated the mercury-induced PLD activation in BPAECs.	Sulfhydryl Compounds	12-17	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	104-107
17365148-9	2007	For the first time, this study revealed that mercury induced the activation of PLD in the vascular ECs wherein cellular thiols and oxidative stress acted as signal mediators for the enzyme activation.	Sulfhydryl Compounds	120-126	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	79-82
17237268-4	2007	N-acetyl-l-cysteine, a thiol-containing antioxidant, completely blocked Bax relocalization, PARP-1 activation, and cytochrome c release.	Sulfhydryl Compounds	23-28	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
17237268-4	2007	N-acetyl-l-cysteine, a thiol-containing antioxidant, completely blocked Bax relocalization, PARP-1 activation, and cytochrome c release.	Sulfhydryl Compounds	23-28	cytochrome c, somatic	Homo sapiens	115-127
32218711-4	2007	The molecular beacon probe is a single-stranded oligonucleotide that has been designed with a hairpin structure that holds the dye at 3"-end close to the particle surface when the probe is attached through a 5"-thiol group.	Sulfhydryl Compounds	211-216	ubiquitin like 5	Homo sapiens	14-20
17095121-8	2007	Oxidative stress generated by l-beta-oxalyl amino-l-alanine itself inhibited cystathionine gamma-lyase, which could be prevented by prior treatment with thiol antioxidant.	Sulfhydryl Compounds	153-158	cystathionase (cystathionine gamma-lyase)	Mus musculus	77-102
17906363-1	2007	The purpose of this work was addressed to provide new information on the effect of thiol reagents on mitochondrial non-specific pore opening, and its response to cyclosporin A (CSA).	Sulfhydryl Compounds	83-88	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	177-180
17912695-9	2007	The interaction of ebselen with the sulfhydryl-containing compounds L-cysteine and reduced glutathione resulted in the complete and partial prevention, respectively, of the inhibition of Pma1p ATPase activity by ebselen.	Sulfhydryl Compounds	36-46	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	187-192
16962833-3	2007	When the effect of exposure of plasma to radical oxygen species on binding of thiols to albumin was determined by the present method, significant increases in the ratio of cysteine bound to albumin (Alb-Cys) to total cysteine were clearly demonstrated.	Sulfhydryl Compounds	78-84	albumin	Homo sapiens	199-202
18351130-1	2007	A novel hydroquinone and NADH oxidase with protein disulfide-thiol interchange activity (designated ENOX2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, is absent from the surface of noncancer cells and from sera from healthy individuals.	Sulfhydryl Compounds	61-66	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	100-105
17518268-1	2007	Phenoxodiol, a synthetic isoflavene with clinical efficacy in the management of ovarian and other forms of human cancer, blocked the activity of a cancer-specific and growth-related cell surface ECTO-NOX protein with both oxidative (hydroquinone) and protein disulfide-thiol interchange activity designated tNOX.	Sulfhydryl Compounds	269-274	tripartite motif-containing 33	Mus musculus	195-199
18351130-1	2007	A novel hydroquinone and NADH oxidase with protein disulfide-thiol interchange activity (designated ENOX2 or tNOX), associated exclusively with the outer leaflet of the plasma membrane at the surface of cancer cells and in sera of cancer patients, is absent from the surface of noncancer cells and from sera from healthy individuals.	Sulfhydryl Compounds	61-66	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	109-113
16458553-3	2007	NAC is a thiol compound which by providing sulfhydryl groups, can act both as a precursor of reduced glutathione and as a direct ROS scavenger, hence regulating the redox status in the cells.	Sulfhydryl Compounds	9-14	synuclein alpha	Homo sapiens	0-3
17518268-1	2007	Phenoxodiol, a synthetic isoflavene with clinical efficacy in the management of ovarian and other forms of human cancer, blocked the activity of a cancer-specific and growth-related cell surface ECTO-NOX protein with both oxidative (hydroquinone) and protein disulfide-thiol interchange activity designated tNOX.	Sulfhydryl Compounds	269-274	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	307-311
17518268-5	2007	Both the oxidative and protein disulfide-thiol interchange activities that alternate to generate the complex set of oscillations with a period length of 22 min (24 min for the constitutive counterpart CNOX) that characterize ECTO-NOX proteins respond to phenoxodiol.	Sulfhydryl Compounds	41-46	ecto-NOX disulfide-thiol exchanger 1	Mus musculus	201-205
17518268-5	2007	Both the oxidative and protein disulfide-thiol interchange activities that alternate to generate the complex set of oscillations with a period length of 22 min (24 min for the constitutive counterpart CNOX) that characterize ECTO-NOX proteins respond to phenoxodiol.	Sulfhydryl Compounds	41-46	tripartite motif-containing 33	Mus musculus	225-229
20020881-6	2007	Sulfhydryl (thiol-protective) agents, calcium chelating agents, and cPLA(2)-specific inhibitor also significantly attenuated the mercury-induced PLA(2), suggesting the role of thiol and calcium in the activation of cPLA(2) in BPAECs.	Sulfhydryl Compounds	176-181	phospholipase A2 group IB	Homo sapiens	69-75
20020881-9	2007	The results of this study revealed that inorganic mercury-induced PLA(2) activation through the thiol and calcium signaling and the formation of bioactive AA metabolites further demonstrated the association of PLA(2) with the cytotoxicity of mercury in ECs.	Sulfhydryl Compounds	96-101	phospholipase A2 group IB	Homo sapiens	66-72
20020881-9	2007	The results of this study revealed that inorganic mercury-induced PLA(2) activation through the thiol and calcium signaling and the formation of bioactive AA metabolites further demonstrated the association of PLA(2) with the cytotoxicity of mercury in ECs.	Sulfhydryl Compounds	96-101	phospholipase A2 group IB	Homo sapiens	210-216
17071618-5	2006	Using a combination of Western blotting and sulfhydryl-directed fluorescent labeling, we found that two large regions of RyR1 (amino acids 1-2401 and 3120-4475), previously shown to be involved in disulfide bond formation, are also major sites of both S-nitrosylation and S-glutathionylation.	Sulfhydryl Compounds	44-54	ryanodine receptor 1	Homo sapiens	121-125
17164327-3	2006	Indeed, we show that thiol reactive compounds of diverse structure activate TRPA1 in a manner that relies on covalent modification of cysteine residues within the cytoplasmic N terminus of the channel.	Sulfhydryl Compounds	21-26	transient receptor potential cation channel subfamily A member 1	Homo sapiens	76-81
17183658-10	2006	Finally, we discovered that yeast cells expressing a TPI variant exhibiting reduced catalytic activity are more resistant against oxidative stress caused by the thiol-oxidizing reagent diamide.	Sulfhydryl Compounds	161-166	triosephosphate isomerase 1	Homo sapiens	53-56
17182766-5	2006	Using the Xenopus oocyte expression system and the SCAM (substituted cysteine accessibility method), we found that M3 segments of both NR1 and NR3A form a narrow constriction in the outer vestibule of the channel, which prevents passage of externally applied sulfhydryl-specific agents.	Sulfhydryl Compounds	259-269	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	135-138
17182766-5	2006	Using the Xenopus oocyte expression system and the SCAM (substituted cysteine accessibility method), we found that M3 segments of both NR1 and NR3A form a narrow constriction in the outer vestibule of the channel, which prevents passage of externally applied sulfhydryl-specific agents.	Sulfhydryl Compounds	259-269	nodal homolog 3, gene 1 L homeolog	Xenopus laevis	143-147
17128987-6	2006	In addition, the results presented herein suggest that the platinated-chemotherapeutic agent, cisplatin, which is known for targeting nucleic acids, reacts with RhoA to produce a RhoA thiol-cisplatin-thiol adduct, leading to inactivation of RhoA.	Sulfhydryl Compounds	184-189	ras homolog family member A	Homo sapiens	161-165
17054907-5	2006	A NO donor S-nitro-N-acetyl-dl-penicillamine (SNAP) inhibited JNK activity in vitro, and this inhibition was reversed by a thiol-reducing agent, dithiothreitol.	Sulfhydryl Compounds	123-128	mitogen-activated protein kinase 8	Homo sapiens	62-65
16927250-5	2006	We identified nine proteins that sensitively reacted to LAA treatment by using two-dimensional (2-D) gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight-MS. A subunit of protein-disulfide isomerase (a thiol/disulfide exchange catalyst) and immunoglobulin-heavy-chain binding protein (BiP, identical to Hsp70 chaperone) showed quantitative expression profile differences.	Sulfhydryl Compounds	232-237	prolyl 4-hydroxylase subunit beta	Homo sapiens	201-228
16927250-5	2006	We identified nine proteins that sensitively reacted to LAA treatment by using two-dimensional (2-D) gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight-MS. A subunit of protein-disulfide isomerase (a thiol/disulfide exchange catalyst) and immunoglobulin-heavy-chain binding protein (BiP, identical to Hsp70 chaperone) showed quantitative expression profile differences.	Sulfhydryl Compounds	232-237	heat shock protein family A (Hsp70) member 5	Homo sapiens	271-313
16927250-5	2006	We identified nine proteins that sensitively reacted to LAA treatment by using two-dimensional (2-D) gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight-MS. A subunit of protein-disulfide isomerase (a thiol/disulfide exchange catalyst) and immunoglobulin-heavy-chain binding protein (BiP, identical to Hsp70 chaperone) showed quantitative expression profile differences.	Sulfhydryl Compounds	232-237	heat shock protein family A (Hsp70) member 5	Homo sapiens	315-318
16927250-5	2006	We identified nine proteins that sensitively reacted to LAA treatment by using two-dimensional (2-D) gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight-MS. A subunit of protein-disulfide isomerase (a thiol/disulfide exchange catalyst) and immunoglobulin-heavy-chain binding protein (BiP, identical to Hsp70 chaperone) showed quantitative expression profile differences.	Sulfhydryl Compounds	232-237	heat shock protein family A (Hsp70) member 5	Homo sapiens	333-338
17046835-1	2006	Keap1 is a BTB-Kelch substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex that functions as a sensor for thiol-reactive chemopreventive compounds and oxidative stress.	Sulfhydryl Compounds	124-129	kelch like ECH associated protein 1	Homo sapiens	0-5
17046835-1	2006	Keap1 is a BTB-Kelch substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex that functions as a sensor for thiol-reactive chemopreventive compounds and oxidative stress.	Sulfhydryl Compounds	124-129	cullin 3	Homo sapiens	53-57
17128987-6	2006	In addition, the results presented herein suggest that the platinated-chemotherapeutic agent, cisplatin, which is known for targeting nucleic acids, reacts with RhoA to produce a RhoA thiol-cisplatin-thiol adduct, leading to inactivation of RhoA.	Sulfhydryl Compounds	184-189	ras homolog family member A	Homo sapiens	179-183
17128987-6	2006	In addition, the results presented herein suggest that the platinated-chemotherapeutic agent, cisplatin, which is known for targeting nucleic acids, reacts with RhoA to produce a RhoA thiol-cisplatin-thiol adduct, leading to inactivation of RhoA.	Sulfhydryl Compounds	184-189	ras homolog family member A	Homo sapiens	179-183
16966321-15	2006	Reaction of the alkylnickel intermediate with thiols regenerates the active MCR(red1) state and eliminates the propylsulfonate group, presumably as the thioether.	Sulfhydryl Compounds	46-52	adenosine deaminase RNA specific B1	Homo sapiens	80-84
17215889-8	2006	Thus, in HMSN-ACC patients with KCC3 mutants, RBC KCC activity, although indistinguishable from that of the control group, responded differently to biochemical stressors, such as thiol alkylation or Mg removal, thereby indirectly indicating an important contribution of KCC3 to overall KCC function and regulation.	Sulfhydryl Compounds	179-184	solute carrier family 12 member 6	Homo sapiens	32-36
17056271-1	2006	Thioredoxin reductase (TrxR)-as part of a major thiol regulating system-allows redox metabolism to adjust to cellular requirements.	Sulfhydryl Compounds	48-53	peroxiredoxin 5	Homo sapiens	0-21
17056271-1	2006	Thioredoxin reductase (TrxR)-as part of a major thiol regulating system-allows redox metabolism to adjust to cellular requirements.	Sulfhydryl Compounds	48-53	peroxiredoxin 5	Homo sapiens	23-27
17056271-3	2006	Three different TrxR isoenzymes, TrxR1 as cytosolic, TrxR2 as mitochondrial, and TrxR3 as testis-specific thiol regulator are known.	Sulfhydryl Compounds	106-111	peroxiredoxin 5	Homo sapiens	16-20
17056271-3	2006	Three different TrxR isoenzymes, TrxR1 as cytosolic, TrxR2 as mitochondrial, and TrxR3 as testis-specific thiol regulator are known.	Sulfhydryl Compounds	106-111	thioredoxin reductase 3	Homo sapiens	81-86
16990275-10	2006	Additionally, the smaller thiol-reactive reagent, methanethiosulfonate ethylsulfonate, reduced transport by wild-type OCT2 and the mutant with cysteine 474 restored.	Sulfhydryl Compounds	26-31	solute carrier family 22 member 2	Homo sapiens	118-122
17073780-7	2006	This paper reviews our current knowledge of these and the other P450 systems in Mtb including recent data relating to the reversible conversion of the CYP51 enzyme between P450 (thiolate-co-ordinated) and P420 (thiol-co-ordinated) species on reduction of the haem iron in the absence of a P450 substrate.	Sulfhydryl Compounds	178-183	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	64-68
17073780-7	2006	This paper reviews our current knowledge of these and the other P450 systems in Mtb including recent data relating to the reversible conversion of the CYP51 enzyme between P450 (thiolate-co-ordinated) and P420 (thiol-co-ordinated) species on reduction of the haem iron in the absence of a P450 substrate.	Sulfhydryl Compounds	178-183	sterol 14-demethylase	Saccharomyces cerevisiae S288C	151-156
17073780-7	2006	This paper reviews our current knowledge of these and the other P450 systems in Mtb including recent data relating to the reversible conversion of the CYP51 enzyme between P450 (thiolate-co-ordinated) and P420 (thiol-co-ordinated) species on reduction of the haem iron in the absence of a P450 substrate.	Sulfhydryl Compounds	178-183	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	172-176
17073780-7	2006	This paper reviews our current knowledge of these and the other P450 systems in Mtb including recent data relating to the reversible conversion of the CYP51 enzyme between P450 (thiolate-co-ordinated) and P420 (thiol-co-ordinated) species on reduction of the haem iron in the absence of a P450 substrate.	Sulfhydryl Compounds	178-183	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	172-176
17096689-6	2006	These finding suggest that GPX isoenzymes may function to detoxify H2O2 and organic hydroperoxides using thioredoxin in vivo and may also be involved in regulation of the cellular redox homeostasis by maintaining the thiol/disulfide or NADPH/NADP balance.	Sulfhydryl Compounds	217-222	glutathione peroxidase 2	Arabidopsis thaliana	27-30
17096689-6	2006	These finding suggest that GPX isoenzymes may function to detoxify H2O2 and organic hydroperoxides using thioredoxin in vivo and may also be involved in regulation of the cellular redox homeostasis by maintaining the thiol/disulfide or NADPH/NADP balance.	Sulfhydryl Compounds	217-222	thioredoxin H-type 1	Arabidopsis thaliana	105-116
17088012-1	2006	Synthetic derivative of C-terminal fragment of CART (55-102) with reduced thiol groups, [Abu(86,94)]CART (85-102)(red), given together with amphetamine (5 mg/kg, s.c.) or cocaine (15 mg/kg, s.c.), reversed hyperlocomotion induced by these drugs at a dose of 0.1 microg but not at a higher dose.	Sulfhydryl Compounds	74-79	CART prepropeptide	Homo sapiens	47-51
16916625-11	2006	This hypothesis was tested by treating Ku86(-/-) mice with the well known free radical scavenger, thiol antioxidant N-acetyl-cysteine (NAC), during embryonic development.	Sulfhydryl Compounds	98-103	X-ray repair complementing defective repair in Chinese hamster cells 5	Mus musculus	39-43
16990421-6	2006	Pearson correlation showed that among all thiols, only total plasma Hcy is related to apoB-Hcy concentrations.	Sulfhydryl Compounds	42-48	apolipoprotein B	Homo sapiens	86-90
17034357-5	2006	By reducing thiols and restoring reversible thiol modifications, thioredoxin and glutaredoxin can act as regulators of ROS-mediated protein function.	Sulfhydryl Compounds	12-18	thioredoxin	Homo sapiens	65-76
17034357-5	2006	By reducing thiols and restoring reversible thiol modifications, thioredoxin and glutaredoxin can act as regulators of ROS-mediated protein function.	Sulfhydryl Compounds	12-18	glutaredoxin	Homo sapiens	81-93
17034357-5	2006	By reducing thiols and restoring reversible thiol modifications, thioredoxin and glutaredoxin can act as regulators of ROS-mediated protein function.	Sulfhydryl Compounds	12-17	thioredoxin	Homo sapiens	65-76
17034357-5	2006	By reducing thiols and restoring reversible thiol modifications, thioredoxin and glutaredoxin can act as regulators of ROS-mediated protein function.	Sulfhydryl Compounds	12-17	glutaredoxin	Homo sapiens	81-93
17073455-7	2006	Furthermore, intermolecular cysteine cross-linking at extracellular position Ser(375) with a bifunctional sulfhydryl reagent dramatically inhibited exchange activity mainly by inducing the acidic shift of pH(i) dependence and abolished extracellular stimuli-induced activation of NHE1 without causing a large change in the affinities for extracellular Na(+) or an inhibitor EIPA.	Sulfhydryl Compounds	106-116	solute carrier family 9 member A1	Homo sapiens	280-284
17052227-1	2006	The RyR (ryanodine receptor)/calcium release channel contains a number of highly reactive thiol groups that endow it with redox sensitivity.	Sulfhydryl Compounds	90-95	ryanodine receptor 1	Homo sapiens	4-7
17052227-1	2006	The RyR (ryanodine receptor)/calcium release channel contains a number of highly reactive thiol groups that endow it with redox sensitivity.	Sulfhydryl Compounds	90-95	ryanodine receptor 1	Homo sapiens	9-27
17052227-3	2006	Thiol modification affects the channel sensitivity to its principal effectors, Ca2+, Mg2+ and ATP, and alters RyR protein interactions.	Sulfhydryl Compounds	0-5	ryanodine receptor 1	Homo sapiens	110-113
17036051-2	2006	To gain structural insight into the dynamic interaction between CFTR"s nucleotide-binding domains (NBDs) proposed to underlie channel gating, we introduced target cysteines into the NBDs, expressed the channels in Xenopus oocytes, and used in vivo sulfhydryl-specific crosslinking to directly examine the cysteines" proximity.	Sulfhydryl Compounds	248-258	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	Xenopus laevis	64-68
16644202-5	2006	The identity of the CPI-0004Na activating enzyme and TOP was further supported by the similar substrate specificity of the purified enzyme and recombinant TOP, by thiol stimulation of CPI-0004Na cleavage by cancer cell conditioned media (unique characteristic of TOP) and by the inhibition of CPI-0004Na activation by specific inhibitors or immunoprecipitation.	Sulfhydryl Compounds	163-168	thimet oligopeptidase 1	Homo sapiens	53-56
16644202-5	2006	The identity of the CPI-0004Na activating enzyme and TOP was further supported by the similar substrate specificity of the purified enzyme and recombinant TOP, by thiol stimulation of CPI-0004Na cleavage by cancer cell conditioned media (unique characteristic of TOP) and by the inhibition of CPI-0004Na activation by specific inhibitors or immunoprecipitation.	Sulfhydryl Compounds	163-168	thimet oligopeptidase 1	Homo sapiens	155-158
16644202-5	2006	The identity of the CPI-0004Na activating enzyme and TOP was further supported by the similar substrate specificity of the purified enzyme and recombinant TOP, by thiol stimulation of CPI-0004Na cleavage by cancer cell conditioned media (unique characteristic of TOP) and by the inhibition of CPI-0004Na activation by specific inhibitors or immunoprecipitation.	Sulfhydryl Compounds	163-168	thimet oligopeptidase 1	Homo sapiens	155-158
17086603-1	2006	OBJECTIVE: The dietary thiol compound and erythrocyte ingredient ergothioneine (ET) is the preferential physiological substrate of the organic cation transporter OCTN1, found to be associated with rheumatoid arthritis (RA) in genetic studies, but the biological roles of ET and OCTN1 are unclear.	Sulfhydryl Compounds	23-28	solute carrier family 22 member 4	Homo sapiens	162-167
17086603-1	2006	OBJECTIVE: The dietary thiol compound and erythrocyte ingredient ergothioneine (ET) is the preferential physiological substrate of the organic cation transporter OCTN1, found to be associated with rheumatoid arthritis (RA) in genetic studies, but the biological roles of ET and OCTN1 are unclear.	Sulfhydryl Compounds	23-28	solute carrier family 22 member 4	Homo sapiens	278-283
17042490-1	2006	In addition to its superoxide dismutase (SOD) activity, Cu,Zn-superoxide dismutase (CuZnSOD) catalyzes the reductive decomposition of S-nitroso-L-glutathione (GSNO) in the presence of thiols such as L-glutathione (GSH).	Sulfhydryl Compounds	184-190	superoxide dismutase 1	Homo sapiens	19-39
17042490-1	2006	In addition to its superoxide dismutase (SOD) activity, Cu,Zn-superoxide dismutase (CuZnSOD) catalyzes the reductive decomposition of S-nitroso-L-glutathione (GSNO) in the presence of thiols such as L-glutathione (GSH).	Sulfhydryl Compounds	184-190	superoxide dismutase 1	Homo sapiens	41-44
17042490-1	2006	In addition to its superoxide dismutase (SOD) activity, Cu,Zn-superoxide dismutase (CuZnSOD) catalyzes the reductive decomposition of S-nitroso-L-glutathione (GSNO) in the presence of thiols such as L-glutathione (GSH).	Sulfhydryl Compounds	184-190	superoxide dismutase 1	Homo sapiens	56-82
17042490-1	2006	In addition to its superoxide dismutase (SOD) activity, Cu,Zn-superoxide dismutase (CuZnSOD) catalyzes the reductive decomposition of S-nitroso-L-glutathione (GSNO) in the presence of thiols such as L-glutathione (GSH).	Sulfhydryl Compounds	184-190	superoxide dismutase 1	Homo sapiens	84-91
18706027-4	2006	It has recently become apparent that vitamin B12 absorption is impaired in the elderly, and that metabolic B12 deficiency is much commoner than would be appreciated by statistical definitions of "normal" serum B12; higher doses of B12 and perhaps other therapies such as betaine and thiols may be needed to achieve adequate reductions of total homocysteine.	Sulfhydryl Compounds	283-289	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	107-110
18706027-4	2006	It has recently become apparent that vitamin B12 absorption is impaired in the elderly, and that metabolic B12 deficiency is much commoner than would be appreciated by statistical definitions of "normal" serum B12; higher doses of B12 and perhaps other therapies such as betaine and thiols may be needed to achieve adequate reductions of total homocysteine.	Sulfhydryl Compounds	283-289	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	107-110
18706027-4	2006	It has recently become apparent that vitamin B12 absorption is impaired in the elderly, and that metabolic B12 deficiency is much commoner than would be appreciated by statistical definitions of "normal" serum B12; higher doses of B12 and perhaps other therapies such as betaine and thiols may be needed to achieve adequate reductions of total homocysteine.	Sulfhydryl Compounds	283-289	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	107-110
17028038-5	2006	In this study, PHEA was firstly functionalised with ethylendiamine, obtaining a well defined copolymer with pendant primary amine groups (PHEA-EDA), to which N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and 3-(carboxypropyl)trimethyl-ammonium chloride (CPTA) were linked in two subsequent steps, allowing the introduction of thiol and cationic groups respectively.	Sulfhydryl Compounds	333-338	ectodysplasin A	Homo sapiens	143-146
17035536-8	2006	Conversely, astrocytes and meningeal cells derived from sut/sut mice (xCT loss-of-function mutants) showed greatly reduced proliferation in culture attributable to increased oxidative stress and thiol deficiency, because growth could be rescued by the thiol-donor beta-mercaptoethanol.	Sulfhydryl Compounds	195-200	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	56-59
16813563-12	2006	Mutant F728C could be cross-linked with a homobifunctional thiol-reactive cross-linker to cysteines I306C(TM5) and F343C(TM6) that are predicted to line the drug-binding pocket.	Sulfhydryl Compounds	59-64	tropomyosin 3	Homo sapiens	106-109
17015178-0	2006	Reduced nonprotein thiols inhibit activation and function of MMP-9: implications for chemoprevention.	Sulfhydryl Compounds	19-25	matrix metallopeptidase 9	Homo sapiens	61-66
17015178-3	2006	A variety of agents, including proteinases and thiol-oxidizing compounds, activate MMPs by initiating release of the propeptide"s cysteine sulfur "blockage" of the MMP active site.	Sulfhydryl Compounds	47-52	matrix metallopeptidase 2	Homo sapiens	83-87
17015178-10	2006	Collectively, these data demonstrate that nonprotein thiols suppress MMP-9 activation and function and introduce the prospect for their use in chemopreventive applications.	Sulfhydryl Compounds	53-59	matrix metallopeptidase 9	Homo sapiens	69-74
17035536-8	2006	Conversely, astrocytes and meningeal cells derived from sut/sut mice (xCT loss-of-function mutants) showed greatly reduced proliferation in culture attributable to increased oxidative stress and thiol deficiency, because growth could be rescued by the thiol-donor beta-mercaptoethanol.	Sulfhydryl Compounds	195-200	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	70-73
17035536-8	2006	Conversely, astrocytes and meningeal cells derived from sut/sut mice (xCT loss-of-function mutants) showed greatly reduced proliferation in culture attributable to increased oxidative stress and thiol deficiency, because growth could be rescued by the thiol-donor beta-mercaptoethanol.	Sulfhydryl Compounds	252-257	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	56-59
17035536-8	2006	Conversely, astrocytes and meningeal cells derived from sut/sut mice (xCT loss-of-function mutants) showed greatly reduced proliferation in culture attributable to increased oxidative stress and thiol deficiency, because growth could be rescued by the thiol-donor beta-mercaptoethanol.	Sulfhydryl Compounds	252-257	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	70-73
16914115-1	2006	One of the major redox-regulating molecules with thiol reducing activity is thioredoxin-1 (TRX-1).	Sulfhydryl Compounds	49-54	thioredoxin	Homo sapiens	76-89
16914115-1	2006	One of the major redox-regulating molecules with thiol reducing activity is thioredoxin-1 (TRX-1).	Sulfhydryl Compounds	49-54	thioredoxin	Homo sapiens	91-96
16928136-0	2006	Complex inhibition of tyrosinase by thiol-composed Cu2+ chelators: a clue for designing whitening agents.	Sulfhydryl Compounds	36-41	tyrosinase	Homo sapiens	22-32
17002301-7	2006	The thiol-alkylating agents N-ethylmaleimide and methyl methanethiolsulfonate block TF activation by ionomycin, while the thiol-oxidizing agent HgCl2 and dithiol cross-linkers promote activation.	Sulfhydryl Compounds	63-68	coagulation factor III, tissue factor	Homo sapiens	84-86
17002301-7	2006	The thiol-alkylating agents N-ethylmaleimide and methyl methanethiolsulfonate block TF activation by ionomycin, while the thiol-oxidizing agent HgCl2 and dithiol cross-linkers promote activation.	Sulfhydryl Compounds	4-9	coagulation factor III, tissue factor	Homo sapiens	84-86
16928443-8	2006	In conclusion, these results indicate that GGT activity confers a growth advantage unrelated with intracellular glutathione supply, and are consistent with the interpretation that cisplatin resistance is the consequence of modifications of cellular pharmacokinetics as a result of extracellular drug inactivation by thiol metabolites originated by GGT-mediated GSH cleavage.	Sulfhydryl Compounds	316-321	gamma-glutamyltransferase light chain family member 3	Homo sapiens	43-46
16855818-1	2006	Herein, we evaluate the binding of Pb(II) and Bi(III) to cysteine-substituted versions of the TRI peptides [AcG-(LKALEEK)4G-NH2] which have previously been shown to bind Hg(II) and Cd(II) in unusual geometries as compared with small-molecule thiol ligands in aqueous solutions.	Sulfhydryl Compounds	242-247	submaxillary gland androgen regulated protein 3B	Homo sapiens	35-41
16928136-2	2006	This study investigated the inhibition effects of thiol-associated Cu(2+) chelators and deduced a strategy for designing and/or selecting tyrosinase inhibitors.	Sulfhydryl Compounds	50-55	tyrosinase	Homo sapiens	138-148
16685525-9	2006	Thiol compounds stimulated by twofold the biosynthetic activity but not the transferase activity of recombinant GLN2 and were able to alter the kinetics towards glutamate of the enzyme.	Sulfhydryl Compounds	0-5	Gln2	Lotus japonicus	112-116
17008981-6	2006	Clopidogrel is metabolized to an active thiol metabolite by the CYP 3A4 enzyme.	Sulfhydryl Compounds	40-45	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-71
16781096-4	2006	Using the specific crosslinkers of dithiothreitol (DTT) and peptide linker, EPO was loaded during HA-MA hydrogel preparation by Michael addition chemistry between thiol and methacrylate groups.	Sulfhydryl Compounds	163-168	erythropoietin	Rattus norvegicus	76-79
16937423-0	2006	Probing, inhibition, and crystallographic characterization of metallo-beta-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups.	Sulfhydryl Compounds	139-144	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	86-91
16808898-2	2006	Gpx3 is a ubiquitously expressed isoform that modulates the activities of redox-sensitive thiol proteins, particularly those involved in signal transduction pathways and protein translocation.	Sulfhydryl Compounds	90-95	peroxiredoxin HYR1	Saccharomyces cerevisiae S288C	0-4
16984172-4	2006	This new approach resulted in potent, reversible, competitive inhibitors of caspase-1 (IC50 &lt; 10 nM), with significant advantages over aldehydes such as high stability in vitro to thiols (10 mM dithiothreitol (pH 7.2), 20 mM glutathione (pH 7.2, 9, 11)) and aqueous media, as well as some highly desirable druglike features.	Sulfhydryl Compounds	183-189	caspase 1	Homo sapiens	76-85
16719839-8	2006	By intraperitoneal injection of [35S]cysteine in wild-type and mutant mice and determination of the specific activity of the chondroitin 4-sulfated disaccharide in cartilage, we demonstrated that the pathway by which sulfate is recruited from the intracellular oxidation of thiols is active in vivo.	Sulfhydryl Compounds	274-280	carbohydrate sulfotransferase 11	Mus musculus	125-138
16777358-3	2006	The thiol-reducing antioxidant N-acetylcyteine attenuated Cd-induced PGE(2) production and COX-2 expression.	Sulfhydryl Compounds	4-9	cytochrome c oxidase II, mitochondrial	Mus musculus	91-96
16987037-3	2006	To prepare alpha-NO-RBC, deoxygenated RBC was treated with FK409, a thiol-free NO donor, at its half molar concentration to that of Hb; this procedure resulted in the 5-coordinated NO binding on the alpha-subunit heme, as judged by electron spin resonance spectrometry.	Sulfhydryl Compounds	68-73	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	38-41
16766608-1	2006	Previous attempts to identify residues that line the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel have utilized cysteine-substituted channels in conjunction with impermeant, thiol-reactive reagents like MTSET+ and MTSES-.	Sulfhydryl Compounds	217-222	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	65-116
16766608-1	2006	Previous attempts to identify residues that line the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel have utilized cysteine-substituted channels in conjunction with impermeant, thiol-reactive reagents like MTSET+ and MTSES-.	Sulfhydryl Compounds	217-222	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	118-122
16766608-3	2006	Exposure of Xenopus oocytes expressing the T338C CFTR channel to as little as 100 nM [Au(CN)2]- produced a profound reduction in conductance that was not reversed by washing but was reversed by exposing the oocytes to a competing thiol like DTT (dithiothreitol) and 2-ME (2-mercaptoethanol).	Sulfhydryl Compounds	230-235	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	49-53
16844966-6	2006	In this work, the authors show that thiol-containing reducing agents can affect catalytic activity of caspase-3 and modify its thermostability in a redox-potential-independent manner.	Sulfhydryl Compounds	36-41	caspase 3	Homo sapiens	102-111
17089213-3	2006	The most studied redox system in photosynthetic organisms is the thioredoxin (TRX) system, involved in the regulation of a growing number of target proteins via thiol/disulfide exchanges.	Sulfhydryl Compounds	161-166	thioredoxin	Homo sapiens	65-76
16690750-4	2006	One of these proteins, protein disulfide isomerase (PDI), has two distinct functions: acting as a molecular chaperone to maintain properly folded proteins and regulating the redox state of proteins by catalyzing the thiol-disulfide exchange reaction through two thioredoxin-like domains.	Sulfhydryl Compounds	216-221	prolyl 4-hydroxylase subunit beta	Homo sapiens	23-50
16690750-4	2006	One of these proteins, protein disulfide isomerase (PDI), has two distinct functions: acting as a molecular chaperone to maintain properly folded proteins and regulating the redox state of proteins by catalyzing the thiol-disulfide exchange reaction through two thioredoxin-like domains.	Sulfhydryl Compounds	216-221	prolyl 4-hydroxylase subunit beta	Homo sapiens	52-55
17089213-3	2006	The most studied redox system in photosynthetic organisms is the thioredoxin (TRX) system, involved in the regulation of a growing number of target proteins via thiol/disulfide exchanges.	Sulfhydryl Compounds	161-166	thioredoxin	Homo sapiens	78-81
16908843-4	2006	Artificially increasing the number of reduced thiols on T cells from animals with arthritis-protective Ncf1 alleles by glutathione treatment lowered the threshold for T cell reactivity and enhanced proliferative responses in vitro and in vivo.	Sulfhydryl Compounds	46-52	neutrophil cytosolic factor 1	Rattus norvegicus	103-107
16860917-10	2006	Sensitive redox proteins such as Nrf-2 recognise oxidative stress and electrophilic agents, through oxidation or covalent modification of thiol groups.	Sulfhydryl Compounds	138-143	NFE2 like bZIP transcription factor 2	Homo sapiens	33-38
16906760-3	2006	We studied the modification of two purified PP2A holoenzyme complexes (ABalpha(FLAG)C and ABdelta(FLAG)C) with two different thiol-reactive electrophiles, biotinyl-iodoacetamidyl-3,6-dioxaoctanediamine (PEO-IAB) and the biotinamido-4-[4"-(maleimidomethyl)cyclohexanecarboxamido]butane (BMCC).	Sulfhydryl Compounds	125-130	protein phosphatase 2 phosphatase activator	Homo sapiens	44-48
16793007-0	2006	Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells.	Sulfhydryl Compounds	0-5	vascular endothelial growth factor A	Homo sapiens	20-56
16901114-3	2006	The kinetics of the reactions of these thiol esters with N-acetyl-l-cysteine (NAC), N-acetylcysteamine, and N(2)-acetyl-L-lysine (NAL) have been studied, and the thiol addition products have been identified.	Sulfhydryl Compounds	39-44	X-linked Kx blood group	Homo sapiens	78-81
16793007-6	2006	Further, thiol depletion by BSO caused a significant induction of VEGFR-1 and VEGFR-2.	Sulfhydryl Compounds	9-14	fms related receptor tyrosine kinase 1	Homo sapiens	66-73
16793007-6	2006	Further, thiol depletion by BSO caused a significant induction of VEGFR-1 and VEGFR-2.	Sulfhydryl Compounds	9-14	kinase insert domain receptor	Homo sapiens	78-85
16682416-6	2006	GAPDH inhibition displayed an IC(50) of approximately 3 microM for both nitroalkenes, an IC(50) equivalent to the potent thiol oxidant peroxynitrite (ONOO(-)) and an IC(50) 30-fold less than H(2)O(2), indicating that nitroalkenes are potent thiol-reactive species.	Sulfhydryl Compounds	121-126	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-5
16869557-0	2006	Optimized biorecognition of cytochrome c 551 and azurin immobilized on thiol-terminated monolayers assembled on Au(111) substrates.	Sulfhydryl Compounds	71-76	cytochrome c, somatic	Homo sapiens	28-40
16220324-1	2006	Glutathione (GSH), the most prevalent intracellular non-protein thiol, plays an important role in the interleukin-2 (IL-2)-induced proliferative activity of normal and tumour cells expressing IL-2 receptor (IL-2R).	Sulfhydryl Compounds	64-69	interleukin 2	Homo sapiens	102-115
16220324-1	2006	Glutathione (GSH), the most prevalent intracellular non-protein thiol, plays an important role in the interleukin-2 (IL-2)-induced proliferative activity of normal and tumour cells expressing IL-2 receptor (IL-2R).	Sulfhydryl Compounds	64-69	interleukin 2	Homo sapiens	117-121
16760193-6	2006	However, the location of the engineered cysteine in these di-scFv-c did influence PEGylation efficiency of this free thiol; higher PEGylation efficiency occurred with this cysteine in the inter-scFv linkage.	Sulfhydryl Compounds	117-122	immunglobulin heavy chain variable region	Homo sapiens	61-65
16764826-9	2006	Collectively, these data suggest that JNK1 is regulated by nNOS-mediated NO production in neurons, via a thiol-redox-sensitive mechanism.	Sulfhydryl Compounds	105-110	mitogen-activated protein kinase 8	Homo sapiens	38-42
16764826-9	2006	Collectively, these data suggest that JNK1 is regulated by nNOS-mediated NO production in neurons, via a thiol-redox-sensitive mechanism.	Sulfhydryl Compounds	105-110	nitric oxide synthase 1	Homo sapiens	59-63
16129553-1	2006	Grapes and grape extracts were compared for inhibition of a growth-related and cancer-specific form of cell surface NADH oxidase with protein disulfide-thiol interchange activity designated tNOX from human cervical carcinoma (HeLa) cells and growth of HeLa and mouse mammary 4T1 cells in culture and transplanted tumors in mice.	Sulfhydryl Compounds	152-157	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	190-194
16682416-8	2006	Liquid chromatography-mass spectrometry-based proteomic analysis of human red cells confirmed that nitroalkenes readily undergo covalent, thiol-reversible post-translational modification of nucleophilic amino acids in GSH and GAPDH in vivo.	Sulfhydryl Compounds	138-143	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	226-231
16111802-0	2006	Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.	Sulfhydryl Compounds	15-20	BCL2 apoptosis regulator	Homo sapiens	119-124
16803874-3	2006	Using the oxidant pervanadate to mimic B cell receptor activation and thiol antioxidants such as N-acetylcysteine (NAC) and glutathione (GSH) we show that CD21 shedding is a redox-regulated process inducible by oxidation presumably through activation of a tyrosine kinase-mediated signal pathway involving protein kinase C (PKC), and by reducing agents that either directly activate the metalloprotease and/or modify intramolecular disulfide bridges within CD21 and thereby facilitate access to the cleavage site.	Sulfhydryl Compounds	70-75	complement C3d receptor 2	Homo sapiens	155-159
16781197-3	2006	We examined the effect of long-term dietary supplementation with the thiol-containing antioxidant, N-acetyl-L-cysteine (NAC), on survival and cancer formation in Atm (AT-mutated) deficient mice, used as an animal model of AT.	Sulfhydryl Compounds	69-74	X-linked Kx blood group	Homo sapiens	120-123
16781197-3	2006	We examined the effect of long-term dietary supplementation with the thiol-containing antioxidant, N-acetyl-L-cysteine (NAC), on survival and cancer formation in Atm (AT-mutated) deficient mice, used as an animal model of AT.	Sulfhydryl Compounds	69-74	ataxia telangiectasia mutated	Mus musculus	162-165
16781197-3	2006	We examined the effect of long-term dietary supplementation with the thiol-containing antioxidant, N-acetyl-L-cysteine (NAC), on survival and cancer formation in Atm (AT-mutated) deficient mice, used as an animal model of AT.	Sulfhydryl Compounds	69-74	ataxia telangiectasia mutated	Mus musculus	167-177
16554059-0	2006	Comparison of the conformational stability of the non-native alpha-helical intermediate of thiol-modified beta-lactoglobulin upon interaction with sodium n-alkyl sulfates at two different pH.	Sulfhydryl Compounds	91-96	beta-lactoglobulin	Bos taurus	106-124
16554059-2	2006	beta-lactoglobulin has a free thiol at Cys121, which is buried between the beta-barrel and the C-terminal major or alpha-helix.	Sulfhydryl Compounds	30-35	beta-lactoglobulin	Bos taurus	0-18
16554059-3	2006	This thiol group was specifically reacted with DTNB (5,5"-dithiobis(2-nitrobenzoic acid)) at pH 7.5 and 2, producing a modified beta-lactoglobulin containing a mix disulfide bond with 5-thio-2-nitrobenzoic acid (TNB).	Sulfhydryl Compounds	5-10	beta-lactoglobulin	Bos taurus	128-146
16554059-5	2006	The formation of non-native alpha-helical intermediate of thiol modified beta-lactoglobulin (TNB-beta-LG) was induced by n-alkyl sulfates including sodium octyl sulfate, SOS; sodium decyl sulfate, SDeS; sodium dodecyl sulfate, SDS; and sodium tetradecyl sulfate, STS at pH 7.5 and 2.	Sulfhydryl Compounds	58-63	beta-lactoglobulin	Bos taurus	73-91
16554059-5	2006	The formation of non-native alpha-helical intermediate of thiol modified beta-lactoglobulin (TNB-beta-LG) was induced by n-alkyl sulfates including sodium octyl sulfate, SOS; sodium decyl sulfate, SDeS; sodium dodecyl sulfate, SDS; and sodium tetradecyl sulfate, STS at pH 7.5 and 2.	Sulfhydryl Compounds	58-63	beta-lactoglobulin	Bos taurus	97-104
16111802-0	2006	Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.	Sulfhydryl Compounds	15-20	caspase 3	Homo sapiens	141-150
16507315-4	2006	However, the cell-surface thiol-reactive reagent 5, 5"-dithiobis(2-nitrobenzoic acid) (DTNB) had a much stronger inhibitory effect in our system, suggesting that cell-surface thiol-containing molecules other than PDI, acting alone or in concert, have a greater effect than PDI on HIV-1 Env-mediated fusion.	Sulfhydryl Compounds	26-31	protein disulfide isomerase family A member 2	Homo sapiens	213-216
16507315-4	2006	However, the cell-surface thiol-reactive reagent 5, 5"-dithiobis(2-nitrobenzoic acid) (DTNB) had a much stronger inhibitory effect in our system, suggesting that cell-surface thiol-containing molecules other than PDI, acting alone or in concert, have a greater effect than PDI on HIV-1 Env-mediated fusion.	Sulfhydryl Compounds	26-31	protein disulfide isomerase family A member 2	Homo sapiens	273-276
16507315-4	2006	However, the cell-surface thiol-reactive reagent 5, 5"-dithiobis(2-nitrobenzoic acid) (DTNB) had a much stronger inhibitory effect in our system, suggesting that cell-surface thiol-containing molecules other than PDI, acting alone or in concert, have a greater effect than PDI on HIV-1 Env-mediated fusion.	Sulfhydryl Compounds	26-31	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	286-289
16507315-4	2006	However, the cell-surface thiol-reactive reagent 5, 5"-dithiobis(2-nitrobenzoic acid) (DTNB) had a much stronger inhibitory effect in our system, suggesting that cell-surface thiol-containing molecules other than PDI, acting alone or in concert, have a greater effect than PDI on HIV-1 Env-mediated fusion.	Sulfhydryl Compounds	175-180	protein disulfide isomerase family A member 2	Homo sapiens	213-216
16507315-4	2006	However, the cell-surface thiol-reactive reagent 5, 5"-dithiobis(2-nitrobenzoic acid) (DTNB) had a much stronger inhibitory effect in our system, suggesting that cell-surface thiol-containing molecules other than PDI, acting alone or in concert, have a greater effect than PDI on HIV-1 Env-mediated fusion.	Sulfhydryl Compounds	175-180	protein disulfide isomerase family A member 2	Homo sapiens	273-276
16507315-4	2006	However, the cell-surface thiol-reactive reagent 5, 5"-dithiobis(2-nitrobenzoic acid) (DTNB) had a much stronger inhibitory effect in our system, suggesting that cell-surface thiol-containing molecules other than PDI, acting alone or in concert, have a greater effect than PDI on HIV-1 Env-mediated fusion.	Sulfhydryl Compounds	175-180	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	286-289
16800712-3	2006	Important factors used to optimize binding characteristics of thrombin to the aptamer-based monolayer films include changes in design elements of the linker and different coadsorbent thiols.	Sulfhydryl Compounds	183-189	coagulation factor II, thrombin	Homo sapiens	62-70
16787573-1	2006	AIM: To elucidate the molecular nature of sulfhydryl modification by hydrogen peroxide on type 1 ryanodine receptor (RyR1).	Sulfhydryl Compounds	42-52	ryanodine receptor 1	Oryctolagus cuniculus	90-115
16802811-3	2006	In this study, we establish the conjugate addition of thiols to enones as a reaction well-suited for the synthesis of dynamic combinatorial libraries (DCLs) directed by the active site of the enzyme glutathione S-transferase (GST).	Sulfhydryl Compounds	54-60	glutathione S-transferase kappa 1	Homo sapiens	199-224
16802811-3	2006	In this study, we establish the conjugate addition of thiols to enones as a reaction well-suited for the synthesis of dynamic combinatorial libraries (DCLs) directed by the active site of the enzyme glutathione S-transferase (GST).	Sulfhydryl Compounds	54-60	glutathione S-transferase kappa 1	Homo sapiens	226-229
16787573-1	2006	AIM: To elucidate the molecular nature of sulfhydryl modification by hydrogen peroxide on type 1 ryanodine receptor (RyR1).	Sulfhydryl Compounds	42-52	ryanodine receptor 1	Oryctolagus cuniculus	117-121
16699765-4	2006	METHODS: HYNIC-maleimide was reacted with the two thiol groups of C-tagged VEGF without any effect on biologic activity in vitro.	Sulfhydryl Compounds	50-55	vascular endothelial growth factor A	Mus musculus	75-79
16817161-4	2006	The increased sensitivity was obtained by drying released apoB thiols after reduction treatment, dissolving them directly in a low volume of derivatization buffer and decreasing the dilution factor of derivatized sample before CE injection.	Sulfhydryl Compounds	63-69	apolipoprotein B	Homo sapiens	58-62
16699765-6	2006	RESULTS: Sequencing analysis of HYNIC-containing peptides obtained after digestion confirmed the site-specific labeling of the two accessible thiol groups of C-tagged VEGF.	Sulfhydryl Compounds	142-147	vascular endothelial growth factor A	Mus musculus	167-171
16453289-7	2006	When soluble ART2 was incubated with serum proteins in the presence of [32P]-labeled NAD, several serum proteins were ADP-ribosylated in a thiol-specific manner.	Sulfhydryl Compounds	139-144	ADP-ribosyltransferase 1	Homo sapiens	13-17
16857017-5	2006	Using LC-ESI-TOFMS and FTMS analysis, we determined that the major structural change in oxidized HSA in healthy human plasma is a disulfide-bonded cysteine at the thiol of Cys34 of reduced HSA.	Sulfhydryl Compounds	163-168	albumin	Homo sapiens	97-100
16700550-3	2006	Because thiol redox reactions are important in signaling and some cells that express iPLA(2)beta produce biological oxidants, iPLA(2)beta might be subject to redox regulation.	Sulfhydryl Compounds	8-13	phospholipase A2 group VI	Homo sapiens	126-137
16551760-2	2006	Glutathione S-transferase (GST) catalyses the nucleophilic addition of the thiol of GST to electrophilic acceptors.	Sulfhydryl Compounds	75-80	glutathione S-transferase kappa 1	Homo sapiens	0-25
16551760-2	2006	Glutathione S-transferase (GST) catalyses the nucleophilic addition of the thiol of GST to electrophilic acceptors.	Sulfhydryl Compounds	75-80	glutathione S-transferase kappa 1	Homo sapiens	27-30
16765949-3	2006	In thiol-reducing conditions PPIase activity of the isolated AtFKBP13 and of the total thylakoid lumen is suppressed several fold.	Sulfhydryl Compounds	3-8	FK506-binding protein 13	Arabidopsis thaliana	61-69
23045137-1	2006	Proteins contain free, exposed thiols that can be glutathionylated in the native state as a result of thiol-disulfide exchange reactions with glutathione disulfide, catalyzed by glutaredoxin.	Sulfhydryl Compounds	31-37	glutaredoxin	Homo sapiens	178-190
23045137-1	2006	Proteins contain free, exposed thiols that can be glutathionylated in the native state as a result of thiol-disulfide exchange reactions with glutathione disulfide, catalyzed by glutaredoxin.	Sulfhydryl Compounds	31-36	glutaredoxin	Homo sapiens	178-190
16704256-3	2006	H-abstraction reactions from thiols and triethylsilane show that the spin density is predominantly localized on both nitrogens.	Sulfhydryl Compounds	29-35	spindlin 1	Homo sapiens	69-73
16551760-2	2006	Glutathione S-transferase (GST) catalyses the nucleophilic addition of the thiol of GST to electrophilic acceptors.	Sulfhydryl Compounds	75-80	glutathione S-transferase kappa 1	Homo sapiens	84-87
16752906-4	2006	Site-specific modification with thiol reagents in single cysteine Pax3 mutants was used to determine which segment of the PD may interact with the HD.	Sulfhydryl Compounds	32-37	paired box 3	Homo sapiens	66-70
16631150-3	2006	The approach was based on the combination of (1)H NMR (600 MHz) spectroscopy with thiol-specific spin labeling of the protein (apoB).	Sulfhydryl Compounds	82-87	apolipoprotein B	Homo sapiens	127-131
16631150-4	2006	It is shown that the spectral peaks assigned to the methyl head groups of phosphatidylcholine and sphingomyelin in the (1)H spectra of LDL exhibit line broadening when otherwise free thiol groups of apoB are covalently modified by methanethiosulfonate spin label.	Sulfhydryl Compounds	183-188	apolipoprotein B	Homo sapiens	199-203
16395611-7	2006	We therefore established a staining protocol using beta-mercaptoethanol as thiol binding site competitor resulting in a specific staining of tetracysteine-tagged reggie-1/flotillin-2 of adequate signal to noise ratio, so that the more toxic and inconvenient ethanedithiol could be avoided.	Sulfhydryl Compounds	75-80	flotillin 2	Homo sapiens	171-182
16586531-1	2006	Thioredoxin superfamily members share a considerable degree of structural similarity, with a conserved CX(i)X(j)C motif at the active site, where C stand for two cysteines that alternate between a reduced thiol and oxidized disulfide states, and X(i)and X(j) are two amino acids different in each family member.	Sulfhydryl Compounds	205-210	thioredoxin	Homo sapiens	0-11
16700014-0	2006	Redox-sensitive contrast agents for MRI based on reversible binding of thiols to serum albumin.	Sulfhydryl Compounds	71-77	albumin	Homo sapiens	81-94
16700014-2	2006	It was hypothesized that these complexes would form reversible covalent linkages with human serum albumin (HSA), which contains a reactive thiol at cysteine-34.	Sulfhydryl Compounds	139-144	albumin	Homo sapiens	92-105
16700014-2	2006	It was hypothesized that these complexes would form reversible covalent linkages with human serum albumin (HSA), which contains a reactive thiol at cysteine-34.	Sulfhydryl Compounds	139-144	albumin	Homo sapiens	107-110
16738309-1	2006	Using a novel thiol affinity chromatography approach to purify macroH2A1-containing chromatin fragments, we examined the distribution of macroH2A1 histone variants in mouse liver chromatin.	Sulfhydryl Compounds	14-19	macroH2A.1 histone	Mus musculus	63-72
16724068-4	2006	PDI catalyses thiol-disulphide exchange, thus facilitating disulphide bond formation and rearrangement reactions.	Sulfhydryl Compounds	14-19	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-3
16554295-2	2006	Specifically, C-terminal, transmembrane residues 45-52 of PLB were individually mutated to Cys, then cross-linked to V89C in the M2 helix of SERCA2a with the thiol-specific cross-linking reagents Cu2+-phenanthroline, dibromobimane, and bismaleimidohexane.	Sulfhydryl Compounds	158-163	phospholamban	Homo sapiens	58-61
16386761-5	2006	In addition, the MGST1 activity increased by nitric oxide (NO) donors such as S-nitrosoglutathione, S-nitrosocysteine or the non-thiol NO donor 1-hydroxy-2-oxo-3 (3-aminopropyl)-3-isopropyl was restored by the DTT treatment.	Sulfhydryl Compounds	129-134	microsomal glutathione S-transferase 1	Homo sapiens	17-22
16386761-6	2006	Since DTT can reduce S-nitrosothiol and disulfide bond to thiol, S-nitrosylation and a mixed disulfide bond formation of MGST1 were suggested.	Sulfhydryl Compounds	30-35	microsomal glutathione S-transferase 1	Rattus norvegicus	121-126
16681396-4	2006	Complete oxidative folding and a near-quantitative recovery of the native SLPI can be achieved in a simple buffer solution using air oxidation without any supplementing thiol catalyst or redox agent, a phenomenon that has not yet been observed with other disulfide proteins.	Sulfhydryl Compounds	169-174	secretory leukocyte peptidase inhibitor	Homo sapiens	74-78
16565085-6	2006	This ester is reductively cleaved by a thiol molecule (RSH) such as GSH, thioredoxin, and dithiothreitol to produce a disulfide-S-monoxide (Prx-Cys-S(=O)-S-R).	Sulfhydryl Compounds	39-44	periaxin	Homo sapiens	140-143
16565085-7	2006	The disulfide-S-monoxide is further reduced through the oxidation of three thiol equivalents to complete the catalytic cycle and regenerate Prx-Cys-SH.	Sulfhydryl Compounds	75-80	periaxin	Homo sapiens	140-143
16565085-6	2006	This ester is reductively cleaved by a thiol molecule (RSH) such as GSH, thioredoxin, and dithiothreitol to produce a disulfide-S-monoxide (Prx-Cys-S(=O)-S-R).	Sulfhydryl Compounds	39-44	thioredoxin	Homo sapiens	73-84
16359746-5	2006	As verified by SDS-PAGE, mass spectrometry and cross-linking experiments with a thiol-specific reagent, intact and properly folded hIL-3 was purified from the B. subtilis growth medium.	Sulfhydryl Compounds	80-85	interleukin 3	Homo sapiens	131-136
16686531-0	2006	Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1" side chain.	Sulfhydryl Compounds	27-32	folate hydrolase 1	Rattus norvegicus	53-82
16686531-1	2006	A series of thiol-based inhibitors containing a benzyl moiety at the P1" position have been synthesized and tested for their abilities to inhibit glutamate carboxypeptidase II (GCP II).	Sulfhydryl Compounds	12-17	folate hydrolase 1	Rattus norvegicus	146-175
16686531-1	2006	A series of thiol-based inhibitors containing a benzyl moiety at the P1" position have been synthesized and tested for their abilities to inhibit glutamate carboxypeptidase II (GCP II).	Sulfhydryl Compounds	12-17	folate hydrolase 1	Rattus norvegicus	177-183
16681396-9	2006	Most importantly, free cysteines of SLPI-6A and SLPI-7A also act as a thiol catalyst in promoting the disulfide shuffling of diverse non-native intermediates accumulated along the folding pathway.	Sulfhydryl Compounds	70-75	secretory leukocyte peptidase inhibitor	Homo sapiens	36-40
16681396-9	2006	Most importantly, free cysteines of SLPI-6A and SLPI-7A also act as a thiol catalyst in promoting the disulfide shuffling of diverse non-native intermediates accumulated along the folding pathway.	Sulfhydryl Compounds	70-75	secretory leukocyte peptidase inhibitor	Homo sapiens	48-52
16681396-10	2006	This explains why a near-quantitative recovery of N-SLPI can be achieved in the absence of any thiol catalyst and redox agent.	Sulfhydryl Compounds	95-100	secretory leukocyte peptidase inhibitor	Homo sapiens	52-56
16167305-2	2006	N-acetyl-cysteine-amide (NACA), the amide form of NAC, is a newly designed and synthesized thiol-containing compound which is believed to be more lipophilic and permeable through cell membranes than NAC.	Sulfhydryl Compounds	91-96	X-linked Kx blood group	Homo sapiens	25-28
16682620-2	2006	Highly specific thiol-containing inhibitors of the human inflammatory caspase-1 were identified by using disulfide trapping, a method for site-directed small-molecule discovery.	Sulfhydryl Compounds	16-21	caspase 1	Homo sapiens	70-79
16543237-9	2006	H2O2-induced [Ca2+]i oscillations and PLC1 phosphorylation were inhibited by pretreatment with dithiothreitol, a sulfhydryl-reducing agent.	Sulfhydryl Compounds	113-123	phospholipase C, delta 1	Rattus norvegicus	38-42
16631159-5	2006	Based on recent observations with several anti-inflammatory and thiol-containing drugs, the present study was designed to test the hypothesis that anti-hypertensive agents from the angiotensin converting enzyme (ACE) inhibitors group inhibit the oxidative modifications of Apo B-100 caused by MPO.	Sulfhydryl Compounds	64-69	angiotensin I converting enzyme	Homo sapiens	181-210
16631159-5	2006	Based on recent observations with several anti-inflammatory and thiol-containing drugs, the present study was designed to test the hypothesis that anti-hypertensive agents from the angiotensin converting enzyme (ACE) inhibitors group inhibit the oxidative modifications of Apo B-100 caused by MPO.	Sulfhydryl Compounds	64-69	angiotensin I converting enzyme	Homo sapiens	212-215
16631159-5	2006	Based on recent observations with several anti-inflammatory and thiol-containing drugs, the present study was designed to test the hypothesis that anti-hypertensive agents from the angiotensin converting enzyme (ACE) inhibitors group inhibit the oxidative modifications of Apo B-100 caused by MPO.	Sulfhydryl Compounds	64-69	apolipoprotein B	Homo sapiens	273-282
16631159-7	2006	Only captopril, a thiol-containing ACE inhibitor, was able to significantly decrease the oxidative modification of LDL in a dose dependent manner and this by scavenging HOCl.	Sulfhydryl Compounds	18-23	angiotensin I converting enzyme	Homo sapiens	35-38
16527817-9	2006	CPR-CP-mediated NO generation was largely thiol-dependent.	Sulfhydryl Compounds	42-47	cytochrome p450 oxidoreductase	Homo sapiens	0-3
16167305-2	2006	N-acetyl-cysteine-amide (NACA), the amide form of NAC, is a newly designed and synthesized thiol-containing compound which is believed to be more lipophilic and permeable through cell membranes than NAC.	Sulfhydryl Compounds	91-96	X-linked Kx blood group	Homo sapiens	50-53
16581878-0	2006	The shoot-specific expression of gamma-glutamylcysteine synthetase directs the long-distance transport of thiol-peptides to roots conferring tolerance to mercury and arsenic.	Sulfhydryl Compounds	106-111	glutamate-cysteine ligase	Arabidopsis thaliana	33-66
16607115-5	2006	The activities of nuclear factor kappaB and activator protein 1 are stimulated not only by hydrogen peroxide, which is produced in tissues by regulated enzymatic processes, but also by an oxidative shift in thiol-disulfide redox status.	Sulfhydryl Compounds	207-212	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-63
16582599-5	2006	Thiol antioxidants, including N-acetyl-L-cycteine (NAC), glutathione (GSH) and dithiothrietol (DTT), abrogated CDDO-Me-induced apoptosis.	Sulfhydryl Compounds	0-5	X-linked Kx blood group	Homo sapiens	30-49
16582599-5	2006	Thiol antioxidants, including N-acetyl-L-cycteine (NAC), glutathione (GSH) and dithiothrietol (DTT), abrogated CDDO-Me-induced apoptosis.	Sulfhydryl Compounds	0-5	X-linked Kx blood group	Homo sapiens	51-54
16582599-7	2006	Accordingly, only thiol antioxidants blocked JNK activation induced by CDDO-Me.	Sulfhydryl Compounds	18-23	mitogen-activated protein kinase 8	Homo sapiens	45-48
16582599-11	2006	Furthermore, these thiol antioxidants abrogated CDDO-Me-induced DR5 expression, whereas the GSH-depleting agent diethylmaleate also upregulated DR5 expression at concentrations that deplete intracellular GSH, demonstrating that GSH depletion can cause DR5 upregulation.	Sulfhydryl Compounds	19-24	TNF receptor superfamily member 10b	Homo sapiens	64-67
16095953-7	2006	SERS spectra for solid composite only exhibit the signals of the CdS nanocrystal which reflected that prolonged refluxing during the synthesis leads to a partial hydrolysis of the thiols and to the incorporation of the sulfur from the thiol molecules into the the growing nanoparticles to form mixed CdTe(S) nanocrystal, similar to CdTe/CdS core/shell structure.	Sulfhydryl Compounds	180-186	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-4
16095953-7	2006	SERS spectra for solid composite only exhibit the signals of the CdS nanocrystal which reflected that prolonged refluxing during the synthesis leads to a partial hydrolysis of the thiols and to the incorporation of the sulfur from the thiol molecules into the the growing nanoparticles to form mixed CdTe(S) nanocrystal, similar to CdTe/CdS core/shell structure.	Sulfhydryl Compounds	180-185	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-4
16438940-7	2006	Moreover, JPL-32 was able to directly oxidize the thiol groups on the purified p50 subunit of recombinant NF-kappaB.	Sulfhydryl Compounds	50-55	nuclear factor kappa B subunit 1	Homo sapiens	79-82
16605247-3	2006	Previously we observed that the catalytic enhancement by glutaredoxin could be ascribed fully to the difference between the pK(a) of its Cys22 thiol moiety and the pK(a) of the product thiol, each acting as a leaving group in the enzymatic and nonenzymatic reactions, respectively [Srinivasan et al.	Sulfhydryl Compounds	143-148	glutaredoxin	Homo sapiens	57-69
16605247-3	2006	Previously we observed that the catalytic enhancement by glutaredoxin could be ascribed fully to the difference between the pK(a) of its Cys22 thiol moiety and the pK(a) of the product thiol, each acting as a leaving group in the enzymatic and nonenzymatic reactions, respectively [Srinivasan et al.	Sulfhydryl Compounds	185-190	glutaredoxin	Homo sapiens	57-69
16605247-14	2006	Changes in the respective Cys22-thiol pK(a) values of the mutant enzymes, as shown by pH profiles for iodoacetamide inactivation of the respective enzymes, clearly revealed that the K19-C22 ion pair cannot fully account for the low pK(a) of the Cys22 thiol.	Sulfhydryl Compounds	32-37	keratin 19	Homo sapiens	182-185
16605247-14	2006	Changes in the respective Cys22-thiol pK(a) values of the mutant enzymes, as shown by pH profiles for iodoacetamide inactivation of the respective enzymes, clearly revealed that the K19-C22 ion pair cannot fully account for the low pK(a) of the Cys22 thiol.	Sulfhydryl Compounds	251-256	keratin 19	Homo sapiens	182-185
16598858-1	2006	The present study demonstrates that mitochondrial cytochrome c reacts with the thiol-reacting agent N-ethylmaleimide (NEM) to produce a one NEM-adducted cytochrome c.	Sulfhydryl Compounds	79-84	cytochrome c, somatic	Homo sapiens	50-62
16598858-1	2006	The present study demonstrates that mitochondrial cytochrome c reacts with the thiol-reacting agent N-ethylmaleimide (NEM) to produce a one NEM-adducted cytochrome c.	Sulfhydryl Compounds	79-84	cytochrome c, somatic	Homo sapiens	153-165
16598858-4	2006	These findings suggest that mitochondrial cytochrome c contains a reactive thiol that is involved in the functions of cytochrome c for mitochondria.	Sulfhydryl Compounds	75-80	cytochrome c, somatic	Homo sapiens	42-54
16598858-4	2006	These findings suggest that mitochondrial cytochrome c contains a reactive thiol that is involved in the functions of cytochrome c for mitochondria.	Sulfhydryl Compounds	75-80	cytochrome c, somatic	Homo sapiens	118-130
16598858-5	2006	Nitric oxide reacts with the cytochrome c thiol to generate S-nitroso (SNO)-cytochrome c in a manner prevented with NEM or IAA.	Sulfhydryl Compounds	42-47	cytochrome c, somatic	Homo sapiens	29-41
16438940-7	2006	Moreover, JPL-32 was able to directly oxidize the thiol groups on the purified p50 subunit of recombinant NF-kappaB.	Sulfhydryl Compounds	50-55	nuclear factor kappa B subunit 1	Homo sapiens	106-115
16598858-5	2006	Nitric oxide reacts with the cytochrome c thiol to generate S-nitroso (SNO)-cytochrome c in a manner prevented with NEM or IAA.	Sulfhydryl Compounds	42-47	cytochrome c, somatic	Homo sapiens	76-88
16438940-8	2006	The oxidative modification of the thiol groups on NF-kappaB by JPL-32 could be ascribed to the intracellular pro-oxidant effect of JPL-32.	Sulfhydryl Compounds	34-39	nuclear factor kappa B subunit 1	Homo sapiens	50-59
16407467-9	2006	TauCl inhibited tumor necrosis factor (TNF)-dependent NF-kappaB activation by modifying thiol(s) on p65 and blocking DNA binding.	Sulfhydryl Compounds	88-93	tumor necrosis factor	Homo sapiens	16-37
16606467-4	2006	In human monocytes, the free thiol compounds DTT and NAC decreased the activity of TGF-beta, without affecting TGF-beta mRNA transcription.	Sulfhydryl Compounds	29-34	synuclein alpha	Homo sapiens	53-56
16606467-4	2006	In human monocytes, the free thiol compounds DTT and NAC decreased the activity of TGF-beta, without affecting TGF-beta mRNA transcription.	Sulfhydryl Compounds	29-34	transforming growth factor beta 1	Homo sapiens	83-91
16533897-4	2006	Previously, we demonstrated that thiol-specific reagents inhibit Kv4.1 channels by reacting in a state-dependent manner with native Zn(2+) site thiolate groups in the T1-T1 interface; therefore, we concluded that the T1-T1 interface is functionally active and not protected by Zn(2+) (Wang, G., M. Shahidullah, C.A.	Sulfhydryl Compounds	33-38	potassium voltage-gated channel subfamily D member 1	Homo sapiens	65-70
16537594-8	2006	We conclude that some ts1-infected astrocytes survive and adapt to virus-induced oxidative stress by successfully mobilizing their thiol redox defenses.	Sulfhydryl Compounds	131-136	Trichinella spiralis resistance 1	Mus musculus	22-25
16537594-6	2006	C1-ts1-S cells also upregulate their thiol antioxidant defenses by activation of the transcription factor NF-E2-related factor 2 (Nrf2) and its target genes.	Sulfhydryl Compounds	37-42	Trichinella spiralis resistance 1	Mus musculus	3-6
16537594-6	2006	C1-ts1-S cells also upregulate their thiol antioxidant defenses by activation of the transcription factor NF-E2-related factor 2 (Nrf2) and its target genes.	Sulfhydryl Compounds	37-42	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
16407467-9	2006	TauCl inhibited tumor necrosis factor (TNF)-dependent NF-kappaB activation by modifying thiol(s) on p65 and blocking DNA binding.	Sulfhydryl Compounds	88-93	tumor necrosis factor	Homo sapiens	39-42
16407467-9	2006	TauCl inhibited tumor necrosis factor (TNF)-dependent NF-kappaB activation by modifying thiol(s) on p65 and blocking DNA binding.	Sulfhydryl Compounds	88-93	RELA proto-oncogene, NF-kB subunit	Homo sapiens	100-103
16407171-6	2006	The membrane association was dynamic in that, within 15 min of treatment with the vicinal-thiol cross-linker phenylarsine oxide, there was a dramatic increase in bulk STAT3 association with sedimentable membranes.	Sulfhydryl Compounds	90-95	signal transducer and activator of transcription 3	Homo sapiens	167-172
16436375-0	2006	Variable reactivity of an engineered cysteine at position 338 in cystic fibrosis transmembrane conductance regulator reflects different chemical states of the thiol.	Sulfhydryl Compounds	159-164	CF transmembrane conductance regulator	Homo sapiens	65-116
16436375-1	2006	In a previous study of T338C CFTR (cystic fibrosis transmembrane conductance regulator) we found that protons and thiol-directed reagents modified channel properties in a manner consistent with the hypothesis that this residue lies within the conduction path, but the observed reactivity was not consistent with the presence of a single thiolate species in the pore.	Sulfhydryl Compounds	114-119	CF transmembrane conductance regulator	Homo sapiens	29-33
16436375-1	2006	In a previous study of T338C CFTR (cystic fibrosis transmembrane conductance regulator) we found that protons and thiol-directed reagents modified channel properties in a manner consistent with the hypothesis that this residue lies within the conduction path, but the observed reactivity was not consistent with the presence of a single thiolate species in the pore.	Sulfhydryl Compounds	114-119	CF transmembrane conductance regulator	Homo sapiens	35-86
16026789-11	2006	There was a significant decrease in the number of free sulfhydryls between Y-PON1 and E-PON1 with respect to cysteine-284 amino acid residues (p&lt;0.0092).	Sulfhydryl Compounds	55-66	paraoxonase 1	Homo sapiens	77-81
16519517-0	2006	Metal ion substitution in the catalytic site greatly affects the binding of sulfhydryl-containing compounds to leucyl aminopeptidase.	Sulfhydryl Compounds	76-86	leucine aminopeptidase 3	Bos taurus	111-132
16236827-12	2006	These experiments demonstrate a profound difference in the sensitivity of shark vs. human CFTR to inhibition by three thiol-reactive substances, an effect that involves C102 in the shark orthologue.	Sulfhydryl Compounds	118-123	CF transmembrane conductance regulator	Homo sapiens	90-94
16540396-17	2006	A persistent marked elevation of MnSOD in cells following their exposure to a thiol-containing reducing agent such as WR1065 can result in an elevated resistance to the cytotoxic effects of ionizing radiation and represents a novel radioprotection paradigm.	Sulfhydryl Compounds	78-83	superoxide dismutase 2	Homo sapiens	33-38
16026789-11	2006	There was a significant decrease in the number of free sulfhydryls between Y-PON1 and E-PON1 with respect to cysteine-284 amino acid residues (p&lt;0.0092).	Sulfhydryl Compounds	55-66	paraoxonase 1	Homo sapiens	88-92
16387289-8	2006	Overall, the acetaldehyde oxidation of hepatic low-molecular thiols depends on mouse liver constituents and GGT is proposed as an important enzyme involved in this phenomenon.	Sulfhydryl Compounds	61-67	gamma-glutamyltransferase 1	Mus musculus	108-111
16360644-6	2006	Pretreatment of cells with reducing agent dithiothreitol dose-dependently reduces EqM-mediated inhibition of NF-kappaB, further suggesting that EqM directly modifies the thiol group of Cys residues in protein targets.	Sulfhydryl Compounds	170-175	nuclear factor kappa B subunit 1	Homo sapiens	109-118
16271041-8	2006	Furthermore, G567C, N565C and I571C mutants were only sensitive to MTSEA (MTS-ethylammonium), a membranepermeant thiol reagent, indicating that these residues may be accessible from the cytoplasmic side of the membrane, providing evidence in support of the predicted orientation of TM 12 in the current putative topology model of hCNT3.	Sulfhydryl Compounds	113-118	solute carrier family 28 member 3	Homo sapiens	330-335
16520229-1	2006	The mammalian thioredoxin system, comprising the selenoenzyme thioredoxin reductase (TrxR) and the 12-kDa protein thioredoxin (Trx), is implicated in thiol-mediated antioxidant defense and redox regulatory processes including transcriptional control, DNA synthesis, and apoptosis.	Sulfhydryl Compounds	150-155	thioredoxin	Homo sapiens	14-25
16520229-1	2006	The mammalian thioredoxin system, comprising the selenoenzyme thioredoxin reductase (TrxR) and the 12-kDa protein thioredoxin (Trx), is implicated in thiol-mediated antioxidant defense and redox regulatory processes including transcriptional control, DNA synthesis, and apoptosis.	Sulfhydryl Compounds	150-155	peroxiredoxin 5	Homo sapiens	62-83
16520229-1	2006	The mammalian thioredoxin system, comprising the selenoenzyme thioredoxin reductase (TrxR) and the 12-kDa protein thioredoxin (Trx), is implicated in thiol-mediated antioxidant defense and redox regulatory processes including transcriptional control, DNA synthesis, and apoptosis.	Sulfhydryl Compounds	150-155	peroxiredoxin 5	Homo sapiens	85-89
16520229-1	2006	The mammalian thioredoxin system, comprising the selenoenzyme thioredoxin reductase (TrxR) and the 12-kDa protein thioredoxin (Trx), is implicated in thiol-mediated antioxidant defense and redox regulatory processes including transcriptional control, DNA synthesis, and apoptosis.	Sulfhydryl Compounds	150-155	thioredoxin	Homo sapiens	62-73
16520229-1	2006	The mammalian thioredoxin system, comprising the selenoenzyme thioredoxin reductase (TrxR) and the 12-kDa protein thioredoxin (Trx), is implicated in thiol-mediated antioxidant defense and redox regulatory processes including transcriptional control, DNA synthesis, and apoptosis.	Sulfhydryl Compounds	150-155	thioredoxin	Homo sapiens	85-88
16754360-0	2006	Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds.	Sulfhydryl Compounds	87-92	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	78-83
16754360-9	2006	ATPase hydrolysis by Atm1p-containing proteoliposomes was specifically increased 3-5-fold by thiol-containing compounds, in particular by micromolar concentrations of cysteine thiol groups in peptides, even though Atm1p is not a general peptide transporter such as yeast Mdl1p or mammalian TAP which share sequence similarity with Atm1p.	Sulfhydryl Compounds	93-98	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	21-26
16754360-9	2006	ATPase hydrolysis by Atm1p-containing proteoliposomes was specifically increased 3-5-fold by thiol-containing compounds, in particular by micromolar concentrations of cysteine thiol groups in peptides, even though Atm1p is not a general peptide transporter such as yeast Mdl1p or mammalian TAP which share sequence similarity with Atm1p.	Sulfhydryl Compounds	93-98	ATP-binding cassette Fe/S cluster precursor transporter ATM1	Saccharomyces cerevisiae S288C	214-219
16754360-9	2006	ATPase hydrolysis by Atm1p-containing proteoliposomes was specifically increased 3-5-fold by thiol-containing compounds, in particular by micromolar concentrations of cysteine thiol groups in peptides, even though Atm1p is not a general peptide transporter such as yeast Mdl1p or mammalian TAP which share sequence similarity with Atm1p.	Sulfhydryl Compounds	93-98	ATP-binding cassette permease MDL1	Saccharomyces cerevisiae S288C	271-276
16754360-9	2006	ATPase hydrolysis by Atm1p-containing proteoliposomes was specifically increased 3-5-fold by thiol-containing compounds, in particular by micromolar concentrations of cysteine thiol groups in peptides, even though Atm1p is not a general peptide transporter such as yeast Mdl1p or mammalian TAP which share sequence similarity with Atm1p.	Sulfhydryl Compounds	93-98	ATP binding cassette subfamily B member 7	Homo sapiens	214-219
16475797-9	2006	The substitution of each Trp residue led to less thiol production compared to that for wild-type GLA, showing that each Trp residue in GLA contributed to the photolytic cleavage of disulfide bridges.	Sulfhydryl Compounds	49-54	alpha-galactosidase A	Capra hircus	97-100
16475797-9	2006	The substitution of each Trp residue led to less thiol production compared to that for wild-type GLA, showing that each Trp residue in GLA contributed to the photolytic cleavage of disulfide bridges.	Sulfhydryl Compounds	49-54	alpha-galactosidase A	Capra hircus	135-138
16387289-9	2006	Thiol depletion, a phenomenon usually observed in the livers of alcoholic patients, can be related to GSH metabolism, and the involvement of GGT may reflect a molecular mechanism involved in thiol oxidation.	Sulfhydryl Compounds	191-196	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	141-144
16481623-7	2006	A proteomics approach in combination with affinity chromatography and a fluorescent thiol probe led to the identification of 42 potential Trx target proteins, 13 not previously recognized, including a major membrane transporter (Brittle-1 or ADP-glucose transporter).	Sulfhydryl Compounds	84-89	thioredoxin H4-2	Triticum aestivum	138-141
16446829-1	2006	A copper(I) complex with new N2S thiol ligand transforms to a multicopper(I) cluster, [(L(S-))6Cu(I)13(S2-)2]3+ (1); its X-ray structure exhibiting mu4-sulfido and mu3-thiolato coordination is presented and compared to other cuprous thiolato/sulfido clusters including that observed in the copper enzyme nitrous oxide reductase.	Sulfhydryl Compounds	33-38	adaptor related protein complex 4 subunit mu 1	Homo sapiens	148-151
16368109-1	2006	The Tanford transition is a conformational change of bovine beta-lactoglobulin (betaLG) occurring at around pH 7, identified originally on the basis of optical rotatory dispersion and the accessibility of a thiol group.	Sulfhydryl Compounds	207-212	beta-lactoglobulin	Bos taurus	60-78
16458196-4	2006	Hdj2 inactivation paralleled the oxidation of cysteine thiols and concomitant release of coordinated zinc, suggesting a role of cysteine residues in the zinc finger domain of Hdj2 as a redox sensor of chaperone-mediated protein-folding machinery.	Sulfhydryl Compounds	55-61	DnaJ heat shock protein family (Hsp40) member A1	Homo sapiens	0-4
16458196-4	2006	Hdj2 inactivation paralleled the oxidation of cysteine thiols and concomitant release of coordinated zinc, suggesting a role of cysteine residues in the zinc finger domain of Hdj2 as a redox sensor of chaperone-mediated protein-folding machinery.	Sulfhydryl Compounds	55-61	DnaJ heat shock protein family (Hsp40) member A1	Homo sapiens	175-179
16364238-1	2006	Human serum albumin (HSA) has one free thiol residue at Cys-34 that is likely oxidized by various reactive oxygen species (ROS).	Sulfhydryl Compounds	39-44	albumin	Homo sapiens	6-25
16412275-5	2006	Second, a site-specific conjugation of Fab" to thiol-specific BAT was performed in a one-step reaction.	Sulfhydryl Compounds	47-52	FA complementation group B	Homo sapiens	39-42
16438969-1	2006	The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance.	Sulfhydryl Compounds	125-130	thioredoxin	Homo sapiens	4-15
16438969-1	2006	The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance.	Sulfhydryl Compounds	125-130	thioredoxin	Homo sapiens	36-47
16438969-1	2006	The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance.	Sulfhydryl Compounds	125-130	thioredoxin	Homo sapiens	49-52
16438969-1	2006	The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance.	Sulfhydryl Compounds	125-130	peroxiredoxin 5	Homo sapiens	58-79
16438969-1	2006	The thioredoxin system, composed of thioredoxin (Trx) and thioredoxin reductase (TrxR), emerges as one of the most important thiol-based systems involved in the maintenance of the cellular redox balance.	Sulfhydryl Compounds	125-130	peroxiredoxin 5	Homo sapiens	81-85
16412275-6	2006	RESULTS: The Fab" fragment had approximately 1.8 free thiol groups per molecule after cysteine reduction.	Sulfhydryl Compounds	54-59	FA complementation group B	Homo sapiens	13-16
16543668-7	2006	Thus the inhibitory effect of insulin and IGF-1 on insulin release is operative and can be disturbed by a thiol interacting compound such as PAO.	Sulfhydryl Compounds	106-111	insulin-like growth factor 1	Rattus norvegicus	42-47
16444599-1	2006	Our work has identified a cancer-specific, cell surface and growth-related quinol oxidase with both NADH oxidase and protein disulfide-thiol interchange activities, a member of the ECTO-NOX protein family designated tNOX.	Sulfhydryl Compounds	135-140	tripartite motif containing 33	Homo sapiens	181-185
16443161-7	2006	Furthermore, using a combination of native and biotin-tagged cytochrome c, this method was used to quantitate the amount of thiol relative to the amount of protein in a given spot on a two-dimensional gel.	Sulfhydryl Compounds	124-129	cytochrome c, somatic	Homo sapiens	61-73
16430697-3	2006	In kinetic studies L. major and human enzymes were active with methylglyoxal derivatives of several thiols, but showed opposite substrate selectivities: N1-glutathionylspermidine hemithioacetal is 40-fold better with L. major GLO1, whereas glutathione hemithioacetal is 300-fold better with human GLO1.	Sulfhydryl Compounds	100-106	glyoxalase I	Homo sapiens	226-230
16430697-3	2006	In kinetic studies L. major and human enzymes were active with methylglyoxal derivatives of several thiols, but showed opposite substrate selectivities: N1-glutathionylspermidine hemithioacetal is 40-fold better with L. major GLO1, whereas glutathione hemithioacetal is 300-fold better with human GLO1.	Sulfhydryl Compounds	100-106	glyoxalase I	Homo sapiens	297-301
16444599-1	2006	Our work has identified a cancer-specific, cell surface and growth-related quinol oxidase with both NADH oxidase and protein disulfide-thiol interchange activities, a member of the ECTO-NOX protein family designated tNOX.	Sulfhydryl Compounds	135-140	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	216-220
16372262-1	2006	Using redox proteomics techniques to characterize the thiol status of proteins in human T lymphocytes, we identified cyclophilin A (CypA) as a specifically oxidized protein early after mitogen activation.	Sulfhydryl Compounds	54-59	peptidylprolyl isomerase A	Homo sapiens	117-130
16372262-1	2006	Using redox proteomics techniques to characterize the thiol status of proteins in human T lymphocytes, we identified cyclophilin A (CypA) as a specifically oxidized protein early after mitogen activation.	Sulfhydryl Compounds	54-59	peptidylprolyl isomerase A	Homo sapiens	132-136
16411783-8	2006	Synthetic Cys-containing peptides are alkylated when incubated with iPLA2beta and BEL, which reflects iPLA2beta-catalyzed BEL hydrolysis to a diffusible bromomethyl keto acid product that reacts with distant thiols.	Sulfhydryl Compounds	208-214	phospholipase A2 group VI	Homo sapiens	68-77
16240315-3	2006	Thiol to disulfide linkage generated a small dynamic library of bifunctional ligands in the presence of calmodulin, a protein with two independently mobile domains.	Sulfhydryl Compounds	0-5	calmodulin 1	Homo sapiens	104-114
16411783-8	2006	Synthetic Cys-containing peptides are alkylated when incubated with iPLA2beta and BEL, which reflects iPLA2beta-catalyzed BEL hydrolysis to a diffusible bromomethyl keto acid product that reacts with distant thiols.	Sulfhydryl Compounds	208-214	phospholipase A2 group VI	Homo sapiens	102-111
16173918-1	2006	The IP3R (inositol 1,4,5-trisphosphate receptor) Ca2+-release channel is known to be sensitive to thiol redox state.	Sulfhydryl Compounds	98-103	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	4-69
16173918-2	2006	The present study was undertaken to characterize the number and location of reactive thiol groups in the type-I IP3R.	Sulfhydryl Compounds	85-90	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	112-116
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Sulfhydryl Compounds	226-231	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
16173918-6	2006	MPEG reaction caused a shift in the mobility of IP3R on SDS/PAGE that was blocked by pretreatment of the membranes with dithiothreitol, N-ethylmaleimide, mersalyl or thimerosal, indicating that MPEG reactivity was specific to thiol groups on the IP3R.	Sulfhydryl Compounds	226-231	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	246-250
16318845-10	2006	Collectively, these findings suggest that Sb(III) seriously compromises thiol homeostasis in THP-1 macrophages and that this may be an early defining event in the mode of action of antimonials against leukaemia cells.	Sulfhydryl Compounds	72-77	GLI family zinc finger 2	Homo sapiens	93-98
16002276-1	2006	Sputtered silicon nitride optical waveguide surfaces were silanized and modified with a hetero-bifunctional crosslinker to facilitate thiol-reactive immobilization of contact-printed DNA probe oligonucleotides, streptavidin and murine anti-human interleukin-1 beta capture agents in microarray formats.	Sulfhydryl Compounds	134-139	interleukin 1 beta	Homo sapiens	246-264
16002276-5	2006	Non-thiolated anti-human interleukin-1 beta printed on modified silicon nitride surfaces reactive to thiol chemistry exhibited comparable performance for capturing human interleukin-1 beta analyte to commercial amine-reactive microarraying polymer surfaces in sandwich immunoassays, indicating substantial non-specific antibody-surface capture responsible for analyte capture signal.	Sulfhydryl Compounds	4-9	interleukin 1 beta	Homo sapiens	25-43
16002276-5	2006	Non-thiolated anti-human interleukin-1 beta printed on modified silicon nitride surfaces reactive to thiol chemistry exhibited comparable performance for capturing human interleukin-1 beta analyte to commercial amine-reactive microarraying polymer surfaces in sandwich immunoassays, indicating substantial non-specific antibody-surface capture responsible for analyte capture signal.	Sulfhydryl Compounds	4-9	interleukin 1 beta	Homo sapiens	170-188
16407140-3	2006	Here, we found that, by using fluorescent tags and immunoprecipitation assays, NEPPs are taken up preferentially into neurons and bind in a thiol-dependent manner to Keap1, a negative regulator of the transcription factor Nrf2.	Sulfhydryl Compounds	140-145	kelch like ECH associated protein 1	Homo sapiens	166-171
16407140-3	2006	Here, we found that, by using fluorescent tags and immunoprecipitation assays, NEPPs are taken up preferentially into neurons and bind in a thiol-dependent manner to Keap1, a negative regulator of the transcription factor Nrf2.	Sulfhydryl Compounds	140-145	NFE2 like bZIP transcription factor 2	Homo sapiens	222-226
16275639-8	2006	In addition, based on the previous observation that SCD is a thiol enzyme, we sought to investigate whether the cysteine residues were essential for enzyme activity through mutagenesis studies, and our data suggest that the cysteines in SCD are not catalytically essential.	Sulfhydryl Compounds	61-66	stearoyl-Coenzyme A desaturase 1	Mus musculus	52-55
16275639-8	2006	In addition, based on the previous observation that SCD is a thiol enzyme, we sought to investigate whether the cysteine residues were essential for enzyme activity through mutagenesis studies, and our data suggest that the cysteines in SCD are not catalytically essential.	Sulfhydryl Compounds	61-66	stearoyl-Coenzyme A desaturase 1	Mus musculus	237-240
16303117-6	2006	Indications exist that the protective effects of GGT may be independent of intracellular glutathione, and derive rather from processes taking place at extracellular level and involving reactions of electrophilic drugs with thiol metabolites originating from GGT-mediated cleavage of extracellular glutathione.	Sulfhydryl Compounds	223-228	gamma-glutamyltransferase light chain family member 3	Homo sapiens	49-52
17206012-4	2006	Electron absorption spectrometry demonstrated that the Cd2+ complexes are coordinated in a tetrahedral fashion by four thiol groups and that several sulfur atoms might bridge Cd2+ ions, resulting in the formation of polynuclear complexes.	Sulfhydryl Compounds	119-124	CD2 molecule	Homo sapiens	55-58
16303117-6	2006	Indications exist that the protective effects of GGT may be independent of intracellular glutathione, and derive rather from processes taking place at extracellular level and involving reactions of electrophilic drugs with thiol metabolites originating from GGT-mediated cleavage of extracellular glutathione.	Sulfhydryl Compounds	223-228	gamma-glutamyltransferase light chain family member 3	Homo sapiens	258-261
16407158-2	2006	It was previously demonstrated that Ero1p can transfer electrons from thiol substrates to molecular oxygen.	Sulfhydryl Compounds	70-75	ER oxidoreductin	Saccharomyces cerevisiae S288C	36-41
17302375-5	2006	Enhancing cellular thiols with N-acetylcystein prevented the NFV-induced drop in reduced thiols and partially protected against the induction in HO-1, but failed to prevent insulin resistance or cleavage of poly ADP ribose polymerase (PARP), a process indicative of activation of pro-apoptotic caspases.	Sulfhydryl Compounds	19-25	heme oxygenase 1	Homo sapiens	145-149
17302375-5	2006	Enhancing cellular thiols with N-acetylcystein prevented the NFV-induced drop in reduced thiols and partially protected against the induction in HO-1, but failed to prevent insulin resistance or cleavage of poly ADP ribose polymerase (PARP), a process indicative of activation of pro-apoptotic caspases.	Sulfhydryl Compounds	19-25	poly(ADP-ribose) polymerase 1	Homo sapiens	235-239
16040186-9	2006	Among the proteins that were more abundant under oxygen exposure, several thiol-specific peroxidases (thiol-peroxidase, BCP-like protein, and putative glutaredoxin) were identified.	Sulfhydryl Compounds	74-79	DVU0883	Desulfovibrio vulgaris str. Hildenborough	151-163
16390138-1	2006	A bifunctional derivative of the thrombin-binding aptamer with a redox-active Fc moiety and a thiol group at the termini of the aptamer strand was synthesized.	Sulfhydryl Compounds	94-99	coagulation factor II, thrombin	Homo sapiens	33-41
16303202-3	2006	Conjugation ratios of the maleimide-activated Dox to the thiol group of a unique cysteine in the ELP were close to unity.	Sulfhydryl Compounds	57-62	nuclear receptor subfamily 5 group A member 1	Homo sapiens	97-100
16343416-5	2006	Chemical modification of the Trx-reduced IIB-III with a thiol-specific modification agent resulted in a complete loss of the peroxidase activity.	Sulfhydryl Compounds	56-61	thioredoxin	Homo sapiens	29-32
17206012-1	2006	An 1H NMR (nuclear magnetic resonance) spectroscopic structural analysis of Cd2+ complexes formed with the pentapeptide phytochelatin, (NH3)+-(gamma-Glu-Cys)2-Gly-COO- (PC2), at a pH of 7.5 showed that the two thiol groups of the Cys residues and either the carbonyl or amide group of the peptide bond between Glu1 and Cys1 act as possible donor groups in the complexes at Cd2+/PC2 ratios up to 0.4.	Sulfhydryl Compounds	210-215	CD2 molecule	Homo sapiens	76-79
16337878-6	2006	For GAPDH each chloramine oxidized two thiols.	Sulfhydryl Compounds	39-45	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	4-9
16337878-8	2006	Competition studies showed that thiols of CK were 4 times more reactive with taurine chloramine than thiols of GAPDH (rate constants of 1200 and 300 M-1s-1 respectively).	Sulfhydryl Compounds	101-107	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	111-116
16337887-9	2006	These findings show that metals have differential oxidative effects on the major thiol antioxidant systems and that activation of apoptosis may be associated with metal ions that oxidize thioredoxin and activate ASK1.	Sulfhydryl Compounds	81-86	thioredoxin	Homo sapiens	187-198
16342971-3	2005	These results suggest that SAMs of densely packed or polypodal thiols may be substantially less stable under tensile stress than previously recognized and that the additional thiolate linkages may not only fail to increase the overall strength of attachment but could actually reduce it.	Sulfhydryl Compounds	63-69	methionine adenosyltransferase 1A	Homo sapiens	27-31
16531095-9	2006	The mechanism of TGF-beta inactivation involved the generation of biologically inactive growth factor monomer and required the presence of free thiol groups, since thiol blockers protected TGF-beta from reduction.	Sulfhydryl Compounds	144-149	transforming growth factor beta 1	Homo sapiens	17-25
16531095-9	2006	The mechanism of TGF-beta inactivation involved the generation of biologically inactive growth factor monomer and required the presence of free thiol groups, since thiol blockers protected TGF-beta from reduction.	Sulfhydryl Compounds	164-169	transforming growth factor beta 1	Homo sapiens	17-25
16531095-9	2006	The mechanism of TGF-beta inactivation involved the generation of biologically inactive growth factor monomer and required the presence of free thiol groups, since thiol blockers protected TGF-beta from reduction.	Sulfhydryl Compounds	164-169	transforming growth factor beta 1	Homo sapiens	189-197
16327902-4	2005	ll-Azi-DAP selectively binds to Cys-73 of the enzyme active site whereas dl-azi-DAP binds to Cys-217 via attack of sulfhydryl on the methylene of the inhibitor aziridine ring.	Sulfhydryl Compounds	115-125	antizyme inhibitor 1	Homo sapiens	76-79
16246300-6	2005	Surprisingly, GSQ incubated with 2-mercapto-ethanol (MSH), a far less reactive thiol, results in the conversion of GSQ into the MSH-adduct MSQ.	Sulfhydryl Compounds	79-84	msh homeobox 2	Homo sapiens	53-56
16246300-6	2005	Surprisingly, GSQ incubated with 2-mercapto-ethanol (MSH), a far less reactive thiol, results in the conversion of GSQ into the MSH-adduct MSQ.	Sulfhydryl Compounds	79-84	msh homeobox 2	Homo sapiens	128-131
16171463-9	2005	Together, the results suggested that free thiol groups, but not disulphide bonding, of seven cysteine residues within the intracisternal region of human UGT1A1 are important for its catalytic activity, while cysteine residues in the cytosolic domain may be involved in its physiological activation by UDP-GlcNAc.	Sulfhydryl Compounds	42-47	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	153-159
16357186-4	2005	This event is most likely due to a peculiar surviving pathway of these cells involving: (a) the formation of mixed disulfides between reduced glutathione (GSH) and protein thiols, (b) a higher and inducible glutathione peroxidase activity, and/or (c) an efficient modulation of the phospho-active levels of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2).	Sulfhydryl Compounds	172-178	mitogen-activated protein kinase 1	Homo sapiens	311-357
16357186-4	2005	This event is most likely due to a peculiar surviving pathway of these cells involving: (a) the formation of mixed disulfides between reduced glutathione (GSH) and protein thiols, (b) a higher and inducible glutathione peroxidase activity, and/or (c) an efficient modulation of the phospho-active levels of the extracellular signal-regulated kinases 1 and 2 (ERK 1/2).	Sulfhydryl Compounds	172-178	mitogen-activated protein kinase 3	Homo sapiens	359-366
16168553-7	2005	Activation of PKC-alpha by GSH-depletion may, at least in part, be mediated by thiol oxidation and may contribute to a survival signal.	Sulfhydryl Compounds	79-84	protein kinase C alpha	Homo sapiens	14-23
16339532-13	2005	These results demonstrate that T cell proliferation is regulated by thiol-sensitive pathway involving IL-2.	Sulfhydryl Compounds	68-73	interleukin 2	Mus musculus	102-106
16150729-1	2005	NAD(P)H oxidase, the main source of reactive oxygen species in vascular cells, is known to be regulated by redox processes and thiols.	Sulfhydryl Compounds	127-133	NADPH oxidase 1	Oryctolagus cuniculus	0-15
16330705-5	2005	In the SR vesicles isolated from the EV-, oxidative stress of the RyR2 (reduction in the number of free thiols) was severe, but it was negligible in EV+.	Sulfhydryl Compounds	104-110	ryanodine receptor 2	Canis lupus familiaris	66-70
17065740-3	2006	However, the crystal structure of the J-chain protein is still far from obtained, because the J-chain expression and its protein downstream has a permanent aggregation problems, due to its two free thiol groups.	Sulfhydryl Compounds	198-203	joining chain of multimeric IgA and IgM	Homo sapiens	38-45
17065740-3	2006	However, the crystal structure of the J-chain protein is still far from obtained, because the J-chain expression and its protein downstream has a permanent aggregation problems, due to its two free thiol groups.	Sulfhydryl Compounds	198-203	joining chain of multimeric IgA and IgM	Homo sapiens	94-101
16185653-9	2005	The activation of TPH1 by incubation with DTT was accompanied by exposure of 9 sulfhydryls out of the total 10 cysteine residues, but the cleavage of disulfide bonds seemed not to be crucial, even if it occurred.	Sulfhydryl Compounds	79-90	tryptophan hydroxylase 1	Homo sapiens	18-22
16387713-3	2005	Thioredoxin (TRX) is a small thiol-mediated protein with a redox-active disulfide/dithiol within the conserved active site.	Sulfhydryl Compounds	29-34	thioredoxin 1	Mus musculus	0-11
16387713-3	2005	Thioredoxin (TRX) is a small thiol-mediated protein with a redox-active disulfide/dithiol within the conserved active site.	Sulfhydryl Compounds	29-34	thioredoxin 1	Mus musculus	13-16
16246122-0	2005	Thiol redox control via thioredoxin and glutaredoxin systems.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	24-35
16246122-0	2005	Thiol redox control via thioredoxin and glutaredoxin systems.	Sulfhydryl Compounds	0-5	glutaredoxin	Homo sapiens	40-52
16246122-1	2005	The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms.	Sulfhydryl Compounds	106-111	thioredoxin	Homo sapiens	4-7
16246122-1	2005	The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms.	Sulfhydryl Compounds	106-111	thioredoxin	Homo sapiens	9-20
16246122-1	2005	The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms.	Sulfhydryl Compounds	106-111	glutaredoxin	Homo sapiens	26-29
16246122-1	2005	The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms.	Sulfhydryl Compounds	106-111	glutaredoxin	Homo sapiens	31-43
16246122-1	2005	The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms.	Sulfhydryl Compounds	201-206	thioredoxin	Homo sapiens	4-7
16246122-1	2005	The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms.	Sulfhydryl Compounds	201-206	thioredoxin	Homo sapiens	9-20
16246122-1	2005	The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms.	Sulfhydryl Compounds	201-206	glutaredoxin	Homo sapiens	26-29
16246122-1	2005	The Trx (thioredoxin) and Grx (glutaredoxin) systems control cellular redox potential, keeping a reducing thiol-rich intracellular state, which on generation of reactive oxygen species signals through thiol redox control mechanisms.	Sulfhydryl Compounds	201-206	glutaredoxin	Homo sapiens	31-43
16288040-5	2005	We previously reported that cystamine and a metabolic cystine precursor inactivate PKCepsilon in cells in a thiol-reversible manner.	Sulfhydryl Compounds	108-113	protein kinase C epsilon	Homo sapiens	83-93
16135660-12	2005	Thus, CYP3A4-dependent secondary oxidation of 2-hydroxycarbamazepine represents a potential carbamazepine bioactivation pathway leading to the formation of thiol-reactive metabolites, intermediates that may play a role in the etiology of idiosyncratic toxicity attributed to carbamazepine.	Sulfhydryl Compounds	156-161	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	6-12
16377906-2	2005	ITC-induced mitochondrial swelling and cytochrome c release were prevented by cyclosporin A, indicating that they are mediated through the ITC moiety-dependent reaction to critical thiol groups for the opening of membrane permeability transition-dependent pores.	Sulfhydryl Compounds	181-186	cytochrome c, somatic	Homo sapiens	39-51
16359182-2	2005	Sulforaphane exerts cancer chemopreventive effects by inducing antioxidant/electrophile response element (ARE)-regulated phase 2 enzyme and antioxidant genes through activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which is regulated by the thiol-rich sensor protein Kelch-like ECH-associated protein 1 (Keap1).	Sulfhydryl Compounds	274-279	NFE2 like bZIP transcription factor 2	Homo sapiens	205-239
16359182-2	2005	Sulforaphane exerts cancer chemopreventive effects by inducing antioxidant/electrophile response element (ARE)-regulated phase 2 enzyme and antioxidant genes through activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which is regulated by the thiol-rich sensor protein Kelch-like ECH-associated protein 1 (Keap1).	Sulfhydryl Compounds	274-279	NFE2 like bZIP transcription factor 2	Homo sapiens	241-245
16246571-7	2005	Tandem mass spectrometry of a synthetic peptide encompassing the C-terminal half of the structurally more labile second zinc finger of ER (ZnF2B) demonstrates that the two nucleophilic thiols in ZnF2B (Cys-237, Cys-240) are not chemically equivalent in their reactivity to bromobimane or menadione, consistent with their unequal positioning near basic amino acids that affect thiol pKa, thereby rendering Cys-240 more reactive than Cys-237.	Sulfhydryl Compounds	185-191	estrogen receptor 1	Homo sapiens	135-137
16246571-7	2005	Tandem mass spectrometry of a synthetic peptide encompassing the C-terminal half of the structurally more labile second zinc finger of ER (ZnF2B) demonstrates that the two nucleophilic thiols in ZnF2B (Cys-237, Cys-240) are not chemically equivalent in their reactivity to bromobimane or menadione, consistent with their unequal positioning near basic amino acids that affect thiol pKa, thereby rendering Cys-240 more reactive than Cys-237.	Sulfhydryl Compounds	185-190	estrogen receptor 1	Homo sapiens	135-137
16428304-2	2005	Treatment of purified cytochrome b(561) in an oxidized state with a sulfhydryl reagent, 4,4"-dithiodipyridine, caused the introduction of only one 4-thiopyridine group per b(561) molecule at either Cys57 or Cys125.	Sulfhydryl Compounds	68-78	cytochrome b	Bos taurus	22-34
16261236-1	2005	Thiol- and thiophene-functionalized SWNTs prepared via the reaction of a substituted amine with fluoronanotubes show similar levels of sidewall functionalization, however, the use of Au nanoparticles as chemical markers for AFM gives misleading results for substituent distribution since STM shows the thiol substituents grouped in bands while the thiophene substituents uniformly distributed along the SWNTs.	Sulfhydryl Compounds	0-5	sulfotransferase family 1A member 3	Homo sapiens	288-291
16288040-7	2005	These results showed that the disulfides inactivated PKCepsilon by thiol-disulfide exchange, either upon Cys452 S-thiolation or by rearrangement to an intra-protein disulfide.	Sulfhydryl Compounds	67-72	protein kinase C epsilon	Homo sapiens	53-63
16268615-6	2005	In the synthesis of 3, 2 equiv of thiol reacts with 1 and the opening of aziridine ring at C-2 was followed by an unusual displacement of the dibenzylamino group by a second equivalent of thiol.	Sulfhydryl Compounds	34-39	complement C2	Homo sapiens	91-94
16171780-0	2005	Thiol-containing molecules interact with the myeloperoxidase/H2O2/chloride system to inhibit LDL oxidation.	Sulfhydryl Compounds	0-5	myeloperoxidase	Homo sapiens	45-60
16356123-1	2005	The chemopreventive agent sulforaphane (SFN) exerts anti-inflammatory activity by thiol-dependent inhibition of nuclear factor kappaB (NF-kappaB) DNA binding.	Sulfhydryl Compounds	82-87	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
16262418-1	2005	We have succeeded for the first time in preparing a pair of gold nanocluster enantiomers protected by optically active thiols: D- and L-penicillamine (D-Pen and L-Pen).	Sulfhydryl Compounds	119-125	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	153-156
16262418-1	2005	We have succeeded for the first time in preparing a pair of gold nanocluster enantiomers protected by optically active thiols: D- and L-penicillamine (D-Pen and L-Pen).	Sulfhydryl Compounds	119-125	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	163-166
16199054-3	2005	In this study, we investigated the effects of the biologically relevant thiol-disulphide redox molecule, glutathione, and Zn2+-binding on the oxidative folding of yeast mitochondrial Tim10 using both biochemical and biophysical methods in vitro.	Sulfhydryl Compounds	72-77	protein transporter TIM10	Saccharomyces cerevisiae S288C	183-188
16356123-7	2005	These findings further emphasize the importance of redox modulation or thiol reactivity for the regulation of NF-kappaB-dependent transcription by SFN.	Sulfhydryl Compounds	71-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
16356134-1	2005	Thioredoxin (Trx) is a redox-active protein that has been shown to regulate various cellular processes due to its thiol-disulfide exchange reaction.	Sulfhydryl Compounds	114-119	thioredoxin	Homo sapiens	0-11
16356134-1	2005	Thioredoxin (Trx) is a redox-active protein that has been shown to regulate various cellular processes due to its thiol-disulfide exchange reaction.	Sulfhydryl Compounds	114-119	thioredoxin	Homo sapiens	13-16
16262253-6	2005	We also found that the C-terminal penultimate selenocysteine was required for transfer of reducing equivalents from the thiol/disulfide active site of TGR to the glutaredoxin domain.	Sulfhydryl Compounds	120-125	thioredoxin reductase 3	Homo sapiens	151-154
16262253-6	2005	We also found that the C-terminal penultimate selenocysteine was required for transfer of reducing equivalents from the thiol/disulfide active site of TGR to the glutaredoxin domain.	Sulfhydryl Compounds	120-125	glutaredoxin	Homo sapiens	162-174
16099502-1	2005	Eu et al., reported that O2 dynamically controls the redox state of 6-8 out of 50 thiols per skeletal ryanodine receptor (RyR1) subunit and thereby tunes the response of Ca2+-release channels to authentic nitric oxide (NO) [J.P. Eu, J.	Sulfhydryl Compounds	82-88	ryanodine receptor 1	Homo sapiens	122-126
16099502-5	2005	At ambient pO2, these critical thiols were oxidized but incubation at low pO2 reset the redox state of these thiols, closed RyR1 channels and made these thiols available for nitrosation by low NO concentrations.	Sulfhydryl Compounds	31-37	ryanodine receptor 1	Homo sapiens	124-128
16222722-9	2005	Results of this study show that the majority of adducts form on proteins that contain reactive thiols in a CXXC motif, such as protein disulfide isomerase A(3) (ERp57), protein disulfide isomerase (PDI), and endothelial PDI.	Sulfhydryl Compounds	95-101	protein disulfide isomerase family A member 3	Homo sapiens	127-159
16222722-9	2005	Results of this study show that the majority of adducts form on proteins that contain reactive thiols in a CXXC motif, such as protein disulfide isomerase A(3) (ERp57), protein disulfide isomerase (PDI), and endothelial PDI.	Sulfhydryl Compounds	95-101	protein disulfide isomerase family A member 3	Homo sapiens	161-166
16236729-6	2005	Reduction assays show that the cysteine thiols in the RCXXC motif of AtCCMH can form a disulfide bond that can be reduced by enzymatic thiol reductants.	Sulfhydryl Compounds	40-46	cytochrome c biogenesis protein family	Arabidopsis thaliana	69-75
16222722-9	2005	Results of this study show that the majority of adducts form on proteins that contain reactive thiols in a CXXC motif, such as protein disulfide isomerase A(3) (ERp57), protein disulfide isomerase (PDI), and endothelial PDI.	Sulfhydryl Compounds	95-101	thioredoxin domain containing 15	Homo sapiens	135-154
16236729-6	2005	Reduction assays show that the cysteine thiols in the RCXXC motif of AtCCMH can form a disulfide bond that can be reduced by enzymatic thiol reductants.	Sulfhydryl Compounds	40-45	cytochrome c biogenesis protein family	Arabidopsis thaliana	69-75
16222722-9	2005	Results of this study show that the majority of adducts form on proteins that contain reactive thiols in a CXXC motif, such as protein disulfide isomerase A(3) (ERp57), protein disulfide isomerase (PDI), and endothelial PDI.	Sulfhydryl Compounds	95-101	protein disulfide isomerase family A member 2	Homo sapiens	198-201
16222722-9	2005	Results of this study show that the majority of adducts form on proteins that contain reactive thiols in a CXXC motif, such as protein disulfide isomerase A(3) (ERp57), protein disulfide isomerase (PDI), and endothelial PDI.	Sulfhydryl Compounds	95-101	protein disulfide isomerase family A member 2	Homo sapiens	220-223
16185709-8	2005	Thiol-trapping assays revealed the co-existence of different oxidation states of human MIA40 within the cell.	Sulfhydryl Compounds	0-5	coiled-coil-helix-coiled-coil-helix domain containing 4	Homo sapiens	87-92
16218868-1	2005	Heterodisulfide reductase (HDR) from methanogenic archaea is an iron-sulfur protein that catalyzes reversible reduction of the heterodisulfide (CoM-S-S-CoB) of the methanogenic thiol-coenzymes, coenzyme M (CoM-SH) and coenzyme B (CoB-SH).	Sulfhydryl Compounds	177-182	metabolism of cobalamin associated B	Homo sapiens	152-155
16190664-1	2005	Bovine beta-lactoglobulin B (beta-LG) is susceptible to pressure treatment, which unfolds it, allowing thiol-catalyzed disulfide bond interchange to occur, facilitating intermolecular bonding (both noncovalent and disulfide).	Sulfhydryl Compounds	103-108	beta-lactoglobulin	Bos taurus	7-27
16190664-1	2005	Bovine beta-lactoglobulin B (beta-LG) is susceptible to pressure treatment, which unfolds it, allowing thiol-catalyzed disulfide bond interchange to occur, facilitating intermolecular bonding (both noncovalent and disulfide).	Sulfhydryl Compounds	103-108	beta-lactoglobulin	Bos taurus	29-36
16194094-1	2005	A novel impedimetric aptasensor using a mixed self-assembled monolayer composed of thiol-modified thrombin binding aptamer and 2-mercaptoethanol on a gold electrode is reported.	Sulfhydryl Compounds	83-88	coagulation factor II, thrombin	Homo sapiens	98-106
16229492-6	2005	Ions at M + n x 31 units were detected in the ESI mass spectra of intact HCalB (n = 1-5) and GAPDH (n = 2), indicating conversion of thiol groups on these proteins to RSONH2 (+31 units).	Sulfhydryl Compounds	133-138	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	93-98
16176268-0	2005	Thiol reducing compounds prevent human amylin-evoked cytotoxicity.	Sulfhydryl Compounds	0-5	islet amyloid polypeptide	Homo sapiens	39-45
15920536-3	2005	In conclusion, a thiol reduction devoid of toxicity as that operated by NAC apparently leads to terminal differentiation of normal and cancer cells through a pleiade of converging mechanisms, many of which are targets of the recently developed differentiation therapy.	Sulfhydryl Compounds	17-22	X-linked Kx blood group	Homo sapiens	72-75
16181973-1	2005	Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a unique intracellular enzyme that directly reduces lipid hydroperoxides in membranes and has the ability to use protein thiol groups as donor substrates.	Sulfhydryl Compounds	182-187	glutathione peroxidase 4	Homo sapiens	0-49
16181973-1	2005	Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a unique intracellular enzyme that directly reduces lipid hydroperoxides in membranes and has the ability to use protein thiol groups as donor substrates.	Sulfhydryl Compounds	182-187	glutathione peroxidase 4	Homo sapiens	51-56
16176268-6	2005	By contrast, the thiol antioxidants, N-acetyl-L-cysteine (NAC), GSH and dithiothreitol, which not only react with ROS, but also modulate the cellular redox potential by increasing intracellular levels of GSH and/or by acting as thiol reducing agents, afford almost complete protection and inhibit the progression of hA-evoked apoptosis.	Sulfhydryl Compounds	17-22	X-linked Kx blood group	Homo sapiens	58-61
16176268-6	2005	By contrast, the thiol antioxidants, N-acetyl-L-cysteine (NAC), GSH and dithiothreitol, which not only react with ROS, but also modulate the cellular redox potential by increasing intracellular levels of GSH and/or by acting as thiol reducing agents, afford almost complete protection and inhibit the progression of hA-evoked apoptosis.	Sulfhydryl Compounds	228-233	X-linked Kx blood group	Homo sapiens	58-61
16037953-3	2005	To explore the feasibility of creating cleavable BP-protein conjugates, an amine- and a thiol-containing BP were conjugated to the model protein Bovine Serum Albumin (BSA) with N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP), which resulted in disulfide-linked BP-BSA conjugates.	Sulfhydryl Compounds	88-93	albumin	Homo sapiens	152-165
15951401-8	2005	Therefore, thiol sensitivity was confirmed following treatment of Hsp90 with the specific thiol modifier N-ethylmaleimide, which resulted in more than 99% inactivation of the chaperone by concentrations as low as 6 microM (1:1 M ratio).	Sulfhydryl Compounds	11-16	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	66-71
15951401-8	2005	Therefore, thiol sensitivity was confirmed following treatment of Hsp90 with the specific thiol modifier N-ethylmaleimide, which resulted in more than 99% inactivation of the chaperone by concentrations as low as 6 microM (1:1 M ratio).	Sulfhydryl Compounds	90-95	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	66-71
16164645-1	2005	BACKGROUND: The activity of the organic anion transporter 1 (OAT1) has been implicated recently in the basolateral uptake of thiol conjugates of inorganic mercury in renal proximal tubular cells.	Sulfhydryl Compounds	125-130	solute carrier family 22 member 6	Rattus norvegicus	61-65
20818013-5	2005	Specifically, we present an improved immobilization method that covalently anchors one end (5" end) of a dual labelled (5"-thiol, 3"-biotin) p53 DNA molecule onto a gold substrate via gold-thiol chemistry, whilst the biotinylated 3" end is available for "pick-up" using a streptavidin modified AFM tip.	Sulfhydryl Compounds	123-128	tumor protein p53	Homo sapiens	141-144
15985429-2	2005	Nrf2 concentrations are regulated by the thiol-rich sensor protein Keap1, which is an adaptor protein for Cul3-dependent ubiquitination and degradation of Nrf2.	Sulfhydryl Compounds	41-46	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
16148150-7	2005	The thiol antioxidant N-acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL-8 increases in response to both phenazines.	Sulfhydryl Compounds	4-9	intercellular adhesion molecule 1	Homo sapiens	112-118
16148150-7	2005	The thiol antioxidant N-acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL-8 increases in response to both phenazines.	Sulfhydryl Compounds	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
16139273-1	2005	Erythrocyte glyceraldehyde-3-phosphate dehydrogenase (G3PD) is a glycolytic enzyme containing critical thiol groups and whose activity is reversibly inhibited by binding to the cell membrane.	Sulfhydryl Compounds	103-108	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	12-52
16139273-1	2005	Erythrocyte glyceraldehyde-3-phosphate dehydrogenase (G3PD) is a glycolytic enzyme containing critical thiol groups and whose activity is reversibly inhibited by binding to the cell membrane.	Sulfhydryl Compounds	103-108	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	54-58
15985429-2	2005	Nrf2 concentrations are regulated by the thiol-rich sensor protein Keap1, which is an adaptor protein for Cul3-dependent ubiquitination and degradation of Nrf2.	Sulfhydryl Compounds	41-46	kelch like ECH associated protein 1	Homo sapiens	67-72
15985429-2	2005	Nrf2 concentrations are regulated by the thiol-rich sensor protein Keap1, which is an adaptor protein for Cul3-dependent ubiquitination and degradation of Nrf2.	Sulfhydryl Compounds	41-46	cullin 3	Homo sapiens	106-110
15985429-2	2005	Nrf2 concentrations are regulated by the thiol-rich sensor protein Keap1, which is an adaptor protein for Cul3-dependent ubiquitination and degradation of Nrf2.	Sulfhydryl Compounds	41-46	NFE2 like bZIP transcription factor 2	Homo sapiens	155-159
16144924-3	2005	A free sulfhydryl donor can mediate plasmin autoproteolysis.	Sulfhydryl Compounds	7-17	plasminogen	Homo sapiens	36-43
16124791-1	2005	Ligand exchange of phosphine-stabilized undecagold precursor particles, Au11(PPh3)8Cl3, with omega-functionalized thiols provides a convenient and general approach for the rapid preparation of large families of thiol-stabilized, subnanometer (dCORE approximately 0.8 nm) particles.	Sulfhydryl Compounds	114-120	caveolin 1	Homo sapiens	77-81
16124791-1	2005	Ligand exchange of phosphine-stabilized undecagold precursor particles, Au11(PPh3)8Cl3, with omega-functionalized thiols provides a convenient and general approach for the rapid preparation of large families of thiol-stabilized, subnanometer (dCORE approximately 0.8 nm) particles.	Sulfhydryl Compounds	114-119	caveolin 1	Homo sapiens	77-81
16173801-8	2005	Complexes 4 and 5 were used for labeling of bovine serum albumin (BSA), enriched in thiol groups by reaction with Traut"s reagent.	Sulfhydryl Compounds	84-89	albumin	Homo sapiens	51-64
16187535-10	2005	It has been suggested that Hg activates the NADH-GDH enzyme in the bean leaf segments by binding to thiol groups of protein and pronounced increase in activity by Hg suggests a possible role of enzyme under Hg-stress.	Sulfhydryl Compounds	100-105	glutamate dehydrogenase 1	Homo sapiens	49-52
16049662-3	2005	The aim of the present study was to examine how glutathione (GSH) and other thiol-containing compounds are involved in the oxidative stress in blood platelets caused by LPS.	Sulfhydryl Compounds	76-81	interferon regulatory factor 6	Homo sapiens	169-172
16049662-6	2005	LPS may react directly with thiols, since after incubation of LPSs with glutathione alone (in reduced form) we observed a distinct decrease of the level of platelet GSH.	Sulfhydryl Compounds	28-34	interferon regulatory factor 6	Homo sapiens	0-3
16127378-12	2005	Modification of multiple thiols results in inactivation but mutation of a single thiol, cysteine 374 in MAO A to alanine, decreased the catalytic potency (kcat/Km) by 30%.	Sulfhydryl Compounds	25-31	monoamine oxidase A	Homo sapiens	104-109
16088041-4	2005	The nonprotein thiol glutathione (GSH), in addition to playing a major role as an antioxidant and in eliminating toxic compounds, has been implicated in prooxidation processes in various cells, via gamma-glutamyl-transpeptidase (gamma-GT)-dependent catabolism.	Sulfhydryl Compounds	15-20	gamma-glutamyltransferase 1	Rattus norvegicus	198-227
16088041-4	2005	The nonprotein thiol glutathione (GSH), in addition to playing a major role as an antioxidant and in eliminating toxic compounds, has been implicated in prooxidation processes in various cells, via gamma-glutamyl-transpeptidase (gamma-GT)-dependent catabolism.	Sulfhydryl Compounds	15-20	gamma-glutamyltransferase 1	Rattus norvegicus	229-237
16088041-12	2005	The results suggest that epididymal NPSH/NPSSNP participates in sperm PSH oxidation and that some reactions of GSH in the gamma-GT pathway (in the epididymis) provide oxidizing power, leading to physiologic sperm thiol oxidation.	Sulfhydryl Compounds	213-218	gamma-glutamyltransferase 1	Rattus norvegicus	122-130
16127378-12	2005	Modification of multiple thiols results in inactivation but mutation of a single thiol, cysteine 374 in MAO A to alanine, decreased the catalytic potency (kcat/Km) by 30%.	Sulfhydryl Compounds	25-30	monoamine oxidase A	Homo sapiens	104-109
16292511-1	2005	Insulin-degrading enzyme (IDE) is a 110-kDa thiol zinc-methalloendopeptidase that can cleave small Abeta peptides and the APP intracellular domain (AICD).	Sulfhydryl Compounds	44-49	insulin degrading enzyme	Mus musculus	0-24
15967877-7	2005	Oxidation of cellular PTEN resulted from thiol modification and led to reversible inhibition of phosphatase activity.	Sulfhydryl Compounds	41-46	phosphatase and tensin homolog	Homo sapiens	22-26
16170035-4	2005	This was conjugated to thiol groups of VEGF at a 4:1 molar ratio using the heterobifunctional reagent sulfo-LC-SPDP.	Sulfhydryl Compounds	23-28	vascular endothelial growth factor A	Mus musculus	39-43
16148069-9	2005	These results suggest that ENO2 may hold promise as a safe alternative to NO, particularly in hypoxemic conditions characterized by thiol depletion.	Sulfhydryl Compounds	132-137	enolase 2	Homo sapiens	27-31
16292511-1	2005	Insulin-degrading enzyme (IDE) is a 110-kDa thiol zinc-methalloendopeptidase that can cleave small Abeta peptides and the APP intracellular domain (AICD).	Sulfhydryl Compounds	44-49	insulin degrading enzyme	Mus musculus	26-29
15993406-3	2005	GCS-null strain showed glutathione auxotrophy and could not grow in medium containing other thiol compounds.	Sulfhydryl Compounds	92-97	glutamate-cysteine ligase catalytic subunit	Homo sapiens	0-3
16268477-9	2005	This suggests that the (R)-configuration of the reactive thiol group of the active metabolite of CS-747 is critical for P2Y12 and platelet inhibitory activities.	Sulfhydryl Compounds	57-62	purinergic receptor P2Y12	Homo sapiens	120-125
15927620-1	2005	CdS nanoparticles, prepared in reverse micellar system, were immobilized onto thiol-modified aluminosilicate particles (ASSH) by a simple operation: addition of ASSH in the micellar solution and mild stirring.	Sulfhydryl Compounds	78-83	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
15818395-2	2005	TRX is a vital component of the thiol-reducing system and regulates various cellular function (redox regulation).	Sulfhydryl Compounds	32-37	thioredoxin	Homo sapiens	0-3
16158536-4	2005	OBJECTIVES: The cellular antioxidant defense system includes thiol-containing proteins such as Trx and TrxR, which have recently attracted much attention due to their strong antioxidant radical quenching capabilities and other important biological functions related to the regulation of the cellular redox state.	Sulfhydryl Compounds	61-66	thioredoxin	Homo sapiens	95-98
16158536-4	2005	OBJECTIVES: The cellular antioxidant defense system includes thiol-containing proteins such as Trx and TrxR, which have recently attracted much attention due to their strong antioxidant radical quenching capabilities and other important biological functions related to the regulation of the cellular redox state.	Sulfhydryl Compounds	61-66	peroxiredoxin 5	Homo sapiens	103-107
16046709-4	2005	IRAK recruitment was shown recently to be inhibited by agents that modify thiols of IRAK.	Sulfhydryl Compounds	74-80	interleukin-1 receptor-associated kinase 1	Mus musculus	0-4
16097802-11	2005	It is proposed that the reaction products of the reduction of selenite inhibited the activity of hGSTO1-1 by reacting with disulfides of glutathionylated cysteines to form bis (S-cysteinyl)selenide and S-selanylcysteine and had little or no interaction with the sulfhydryl of Cys-32 in the active site of the enzyme.	Sulfhydryl Compounds	262-272	glutathione S-transferase omega 1	Homo sapiens	97-105
16097806-6	2005	Thiol sensitivity was confirmed through concentration-dependent inhibition of PDI by the Cys modifier N-ethylmaleimide (NEM).	Sulfhydryl Compounds	0-5	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	78-81
16046709-4	2005	IRAK recruitment was shown recently to be inhibited by agents that modify thiols of IRAK.	Sulfhydryl Compounds	74-80	interleukin-1 receptor-associated kinase 1	Mus musculus	84-88
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Sulfhydryl Compounds	29-35	interleukin-1 receptor-associated kinase 1	Mus musculus	24-28
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Sulfhydryl Compounds	29-35	interleukin-1 receptor-associated kinase 1	Mus musculus	82-86
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Sulfhydryl Compounds	29-35	interleukin-1 receptor-associated kinase 1	Mus musculus	88-98
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Sulfhydryl Compounds	29-35	interleukin-1 receptor-associated kinase 1	Mus musculus	82-86
16046709-6	2005	Curcumin indeed blocked IRAK thiols in a murine T-cell line stably overexpressing IRAK (EL-4(IRAK)), which resulted in the inhibition of IRAK recruitment to the IL-1RI and phosphorylation of IRAK and IL-1RI-associated proteins.	Sulfhydryl Compounds	29-35	interleukin-1 receptor-associated kinase 1	Mus musculus	82-86
15990177-1	2005	Thioredoxin (Trx), a small, ubiquitous thiol [sulfydryl (-SH)] protein, is one of the most important regulators of reduction-oxidation (redox) balance and, thus, redox-controlled cell functions.	Sulfhydryl Compounds	39-44	thioredoxin	Homo sapiens	0-11
15901913-5	2005	While Nrf2 activation is often linked to perturbation of cellular thiol status and/or oxidative stress, we were unable to detect any significant depletion of cellular glutathione or oxidation of mitochondrial membrane cardiolipin or increases in reactive oxygen species (ROS).	Sulfhydryl Compounds	66-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	6-10
15990177-1	2005	Thioredoxin (Trx), a small, ubiquitous thiol [sulfydryl (-SH)] protein, is one of the most important regulators of reduction-oxidation (redox) balance and, thus, redox-controlled cell functions.	Sulfhydryl Compounds	39-44	thioredoxin	Homo sapiens	13-16
15883162-5	2005	Comparing Ahr(-/-) knock-out and wild-type mice, we found that TCDD-induced thiol changes in both cytosol and mitochondria were dependent on the aromatic hydrocarbon receptor (AHR).	Sulfhydryl Compounds	76-81	aryl-hydrocarbon receptor	Mus musculus	10-13
15990096-0	2005	Unfolding and breakdown of insulin in the presence of endogenous thiols.	Sulfhydryl Compounds	65-71	insulin	Homo sapiens	27-34
15990096-1	2005	Native insulin denatures and unfolds in the presence of thiol catalyst via disulfide scrambling (isomerization).	Sulfhydryl Compounds	56-61	insulin	Homo sapiens	7-14
15990096-7	2005	These results demonstrate that stability and unfolding pathway of insulin in the presence of endogenous thiol differ fundamentally from its reversible denaturation observed in the absence of thiol, in which native disulfide bonds of insulin were kept intact during the process of denaturation.	Sulfhydryl Compounds	104-109	insulin	Homo sapiens	66-73
15990096-7	2005	These results demonstrate that stability and unfolding pathway of insulin in the presence of endogenous thiol differ fundamentally from its reversible denaturation observed in the absence of thiol, in which native disulfide bonds of insulin were kept intact during the process of denaturation.	Sulfhydryl Compounds	191-196	insulin	Homo sapiens	66-73
16011359-2	2005	Scanning tunneling microscopy (STM) measurements of compound 2 inserted into a SAM of C11 thiol reveal that molecule 2 exhibits (i) the stochastic switching characteristic of wire molecules embedded in insulating SAMs and (ii) higher conductivity than the C11 thiol SAM.	Sulfhydryl Compounds	90-95	methionine adenosyltransferase 1A	Homo sapiens	213-217
16011359-2	2005	Scanning tunneling microscopy (STM) measurements of compound 2 inserted into a SAM of C11 thiol reveal that molecule 2 exhibits (i) the stochastic switching characteristic of wire molecules embedded in insulating SAMs and (ii) higher conductivity than the C11 thiol SAM.	Sulfhydryl Compounds	260-265	methionine adenosyltransferase 1A	Homo sapiens	213-217
15901730-7	2005	We found that TGR can catalyze isomerization of protein and interprotein disulfide bonds and localized this function to its thiol domain.	Sulfhydryl Compounds	124-129	thioredoxin reductase 3	Homo sapiens	14-17
15883162-5	2005	Comparing Ahr(-/-) knock-out and wild-type mice, we found that TCDD-induced thiol changes in both cytosol and mitochondria were dependent on the aromatic hydrocarbon receptor (AHR).	Sulfhydryl Compounds	76-81	aryl-hydrocarbon receptor	Mus musculus	145-174
15883162-5	2005	Comparing Ahr(-/-) knock-out and wild-type mice, we found that TCDD-induced thiol changes in both cytosol and mitochondria were dependent on the aromatic hydrocarbon receptor (AHR).	Sulfhydryl Compounds	76-81	aryl-hydrocarbon receptor	Mus musculus	176-179
16029043-3	2005	The derivatives thus obtained were conjugated to the free thiol on Cys34 of human serum albumin (HSA) and purified.	Sulfhydryl Compounds	58-63	albumin	Homo sapiens	82-101
15982000-0	2005	Crystal structures of potent thiol-based inhibitors bound to carboxypeptidase B.	Sulfhydryl Compounds	29-34	carboxypeptidase B1	Homo sapiens	61-79
15982000-1	2005	This paper presents the crystal structure of porcine pancreatic carboxypeptidase B (pp-CpB) in complex with a variety of thiol-based inhibitors that were developed as antagonists of activated thrombin-activatable fibrinolysis inhibitor (TAFIa).	Sulfhydryl Compounds	121-126	carboxypeptidase B1	Homo sapiens	53-82
15982000-1	2005	This paper presents the crystal structure of porcine pancreatic carboxypeptidase B (pp-CpB) in complex with a variety of thiol-based inhibitors that were developed as antagonists of activated thrombin-activatable fibrinolysis inhibitor (TAFIa).	Sulfhydryl Compounds	121-126	carboxypeptidase B2	Homo sapiens	192-235
15998246-1	2005	Previous studies have documented that activity of the plasma membrane enzyme gamma-glutamyltransferase (GGT) is accompanied by prooxidant processes, with production of reactive oxygen species and oxidation of cellular protein thiols.	Sulfhydryl Compounds	226-232	gamma-glutamyltransferase light chain family member 3	Homo sapiens	77-102
15998246-1	2005	Previous studies have documented that activity of the plasma membrane enzyme gamma-glutamyltransferase (GGT) is accompanied by prooxidant processes, with production of reactive oxygen species and oxidation of cellular protein thiols.	Sulfhydryl Compounds	226-232	gamma-glutamyltransferase light chain family member 3	Homo sapiens	104-107
15984876-1	2005	Recent studies suggest that the developmental toxicity associated with childhood lead poisoning may be attributable to interactions of Pb(II) with proteins containing thiol-rich structural zinc-binding sites.	Sulfhydryl Compounds	167-172	submaxillary gland androgen regulated protein 3B	Homo sapiens	135-141
15998262-3	2005	However, insulin receptor kinase (IRK) autophosphorylation and/or kinase activity were found to be markedly enhanced by a more limited exposure to hydrogen peroxide or by an oxidative shift in the thiol/disulfide redox status.	Sulfhydryl Compounds	197-202	insulin	Homo sapiens	9-16
15998262-7	2005	In line with the oxidative enhancement of IRK activity, clinical studies have shown that treatment with a thiol-containing antioxidant increases the postabsorptive glucose and/or insulin concentrations (i.e., the HOMA-R index) at least under certain conditions.	Sulfhydryl Compounds	106-111	insulin	Homo sapiens	179-186
16029046-8	2005	Alternatively, thiol-decorated (nonderivatized) micelles are prepared and show improved mucoadhesion through the formation of disulfide bonds with mucin.	Sulfhydryl Compounds	15-20	LOC100508689	Homo sapiens	147-152
15953034-0	2005	The increase in mucin exocytosis and the upregulation of MUC genes encoding for membrane-bound mucins induced by the thiol-activated exotoxin listeriolysin O is a host cell defence response that inhibits the cell-entry of Listeria monocytogenes.	Sulfhydryl Compounds	117-122	LOC100508689	Homo sapiens	16-21
15880142-7	2005	CORM-2 or CORM-3 did not cause any evident cytotoxicity and produced an increase in HO-1 expression and heme oxygenase activity; this effect was completely prevented by the thiol donor N-acetylcysteine.	Sulfhydryl Compounds	173-178	heme oxygenase 1	Homo sapiens	84-88
15879598-2	2005	TrxRs are the only enzymes catalyzing the NADPH-dependent reduction of the active site disulfide in thioredoxins (Trxs), which play essential roles in substrate reductions, defense against oxidative stress, and redox regulation by thiol redox control.	Sulfhydryl Compounds	231-236	thioredoxin 1	Rattus norvegicus	100-112
15830337-3	2005	It resulted that thiol-derived MRPs were highly prone to give rise to inhibitory compounds of PPO activity.	Sulfhydryl Compounds	17-22	polyphenol oxidase, chloroplastic	Malus domestica	94-97
15635671-3	2005	The building blocks, ORL1(329-370) and ORL1(288-328)-SR-Gly-Arg(5)-Leu (-SR- : -SCH(2)CH(2)CO-) were most effectively condensed slightly below the critical micelle concentration of SDS and in the presence of mercaptoethanesulfonic acid as a thiol additive.	Sulfhydryl Compounds	241-246	opioid related nociceptin receptor 1	Homo sapiens	21-25
15635671-3	2005	The building blocks, ORL1(329-370) and ORL1(288-328)-SR-Gly-Arg(5)-Leu (-SR- : -SCH(2)CH(2)CO-) were most effectively condensed slightly below the critical micelle concentration of SDS and in the presence of mercaptoethanesulfonic acid as a thiol additive.	Sulfhydryl Compounds	241-246	opioid related nociceptin receptor 1	Homo sapiens	39-43
15855216-12	2005	The altered kinetic properties of THP in these subjects were strongly associated with increased carbonyl content and with decreased thiol and sialic acid contents.	Sulfhydryl Compounds	132-137	uromodulin	Homo sapiens	34-37
15896810-6	2005	Recent evidence suggests that frataxin might detoxify ROS via activation of glutathione peroxidase and elevation of thiols, and in addition, that decreased expression of frataxin protein is associated with FRDA.	Sulfhydryl Compounds	116-122	frataxin	Homo sapiens	30-38
15954778-9	2005	The STM images showed that the catalyst-bearing thiolates are distributed statistically on the surface and that the ordered structure of the n-octanethiolate SAM can be retained during incorporation of the catalyst-bearing thiols using the place-exchange methodology.	Sulfhydryl Compounds	223-229	sulfotransferase family 1A member 3	Homo sapiens	4-7
15963926-7	2005	Furthermore, this technology could be efficiently combined with vector shielding for true retargeting: after amino-PEGylation of the vector particles the genetically introduced thiols were still accessible for ligand coupling, and particles could be retargeted to the transferrin receptor.	Sulfhydryl Compounds	177-183	transferrin	Homo sapiens	268-279
15950210-11	2005	Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols.	Sulfhydryl Compounds	121-127	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	23-28
15950210-11	2005	Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols.	Sulfhydryl Compounds	121-127	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	115-120
15950210-11	2005	Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols.	Sulfhydryl Compounds	121-127	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	115-120
15950210-11	2005	Thus, 9,10-PQ inhibits GAPDH by two distinct mechanisms: through ROS generation that results in the oxidization of GAPDH thiols, and by an oxygen-independent mechanism that results in the modification of GAPDH catalytic thiols.	Sulfhydryl Compounds	220-226	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	23-28
15917183-2	2005	This novel antioxidant enzyme was shown to reduce hydroperoxides and, more recently, peroxynitrite with the use of electrons provided by a physiological thiol like thioredoxin.	Sulfhydryl Compounds	153-158	thioredoxin	Homo sapiens	164-175
15814611-2	2005	Glutaredoxin (Grx) and protein-disulfide isomerase (PDI) are members of the thioredoxin superfamily of thiol/disulfide exchange catalysts.	Sulfhydryl Compounds	103-108	glutaredoxin	Rattus norvegicus	0-12
15894008-11	2005	Taken overall, our finding suggests that EA treatment at GB20 or ST36 could increase Trx expression which could minimize oxidative modifications of thiol groups of surrounding proteins.	Sulfhydryl Compounds	148-153	thioredoxin 1	Rattus norvegicus	85-88
15814611-2	2005	Glutaredoxin (Grx) and protein-disulfide isomerase (PDI) are members of the thioredoxin superfamily of thiol/disulfide exchange catalysts.	Sulfhydryl Compounds	103-108	glutaredoxin	Rattus norvegicus	14-17
15814611-2	2005	Glutaredoxin (Grx) and protein-disulfide isomerase (PDI) are members of the thioredoxin superfamily of thiol/disulfide exchange catalysts.	Sulfhydryl Compounds	103-108	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	23-50
15814611-2	2005	Glutaredoxin (Grx) and protein-disulfide isomerase (PDI) are members of the thioredoxin superfamily of thiol/disulfide exchange catalysts.	Sulfhydryl Compounds	103-108	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	52-55
15814611-2	2005	Glutaredoxin (Grx) and protein-disulfide isomerase (PDI) are members of the thioredoxin superfamily of thiol/disulfide exchange catalysts.	Sulfhydryl Compounds	103-108	thioredoxin 1	Rattus norvegicus	76-87
15984205-2	2005	The thiol derivatives used included 2-mercaptoethanesulfonic acid (MES), 2-mercaptoacetic acid (MAA), and N-acetyl-L-cysteine (NAC).	Sulfhydryl Compounds	4-9	X-linked Kx blood group	Homo sapiens	127-130
15975510-2	2005	The present study shows that, like MGL, 2-AG-degrading enzymatic activity is sensitive to inhibition by sulfhydryl-specific reagents.	Sulfhydryl Compounds	104-114	monoglyceride lipase	Rattus norvegicus	35-38
15869797-1	2005	The synthesis and biological evaluation of platinum(II) amine complexes designed to act as inhibitors of the human cysteine protease cathepsin B, a thiol-dependent enzyme, is described.	Sulfhydryl Compounds	148-153	cathepsin B	Homo sapiens	133-144
15865434-9	2005	Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity.	Sulfhydryl Compounds	16-21	kelch-like ECH-associated protein 1	Mus musculus	0-5
15834431-1	2005	Thioredoxin is a major component of thiol-reducing system.	Sulfhydryl Compounds	36-41	thioredoxin 1	Rattus norvegicus	0-11
15792952-1	2005	The homodimeric flavoprotein glutathione reductase (GR) is a central player of cellular redox metabolism, connecting NADPH to the large pool of redox-active thiols.	Sulfhydryl Compounds	157-163	glutathione-disulfide reductase	Homo sapiens	29-50
15792952-1	2005	The homodimeric flavoprotein glutathione reductase (GR) is a central player of cellular redox metabolism, connecting NADPH to the large pool of redox-active thiols.	Sulfhydryl Compounds	157-163	glutathione-disulfide reductase	Homo sapiens	52-54
15798974-1	2005	We describe the synthetic route to ethylenediaminetetraacetic acid (EDTA) derivatives that can be attached to surface-exposed thiol functional groups of cysteine residues in proteins, via a methylthiosulfonate moiety that is connected in a stereochemically unique way to the C-1 carbon atom of EDTA.	Sulfhydryl Compounds	126-131	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	275-278
15855051-2	2005	Our previous studies demonstrated that thiol depletion using diethyl maleate (DEM) reduced neutrophil sequestration in animal models of inflammation, an effect primarily mediated by impaired upregulation of the adhesion molecule, ICAM-1.	Sulfhydryl Compounds	39-44	intercellular adhesion molecule 1	Homo sapiens	230-236
15855054-8	2005	These results demonstrate that *NO exposure is capable of inducing an adaptive response to H2O2-mediated oxidative stress in mammalian cells, which involves alterations in thiol metabolism and is dependent upon glutathione synthesis and increased GCL activity.	Sulfhydryl Compounds	172-177	glutamate-cysteine ligase catalytic subunit	Homo sapiens	247-250
15923610-2	2005	In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN), i.e., "antioxidants" known to activate the "antioxidant response element" (ARE) via electrophilic thiol modification of Keap1 in the Nrf2/Keap1 system.	Sulfhydryl Compounds	189-194	glutathione peroxidase 2	Homo sapiens	17-23
15788408-11	2005	In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression.	Sulfhydryl Compounds	30-35	vascular endothelial growth factor A	Homo sapiens	104-108
15788408-11	2005	In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression.	Sulfhydryl Compounds	30-35	eukaryotic translation initiation factor 2A	Homo sapiens	177-186
15788408-11	2005	In addition, the ability of a thiol antioxidant, N-acetylcysteine, to inhibit the effect of arsenite on VEGF expression coincided with its ability to inhibit phosphorylation of eIF2alpha and ATF4 protein expression.	Sulfhydryl Compounds	30-35	activating transcription factor 4	Homo sapiens	191-195
15907113-0	2005	[Os(bpy)2(CO)(enIA)][OTf]2: a novel sulfhydryl-specific metal-ligand complex.	Sulfhydryl Compounds	36-46	POU class 2 homeobox 2	Homo sapiens	21-26
15907113-1	2005	The synthesis and physical-chemical characterization of the metal-ligand complex [Os(bpy)2(CO)(enIA)][OTf]2 (where enIA = ethylenediamine iodoacetamide) with a sulfhydryl-specific functional group is described.	Sulfhydryl Compounds	160-170	POU class 2 homeobox 2	Homo sapiens	102-107
15865434-9	2005	Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity.	Sulfhydryl Compounds	98-103	kelch-like ECH-associated protein 1	Mus musculus	0-5
15890017-3	2005	The thiol antioxidant, N-acetyl-L-cysteine (NAC), was used to alter intracellular redox state in nonmalignant human breast epithelial (MCF-10A) and breast cancer cells (MCF-7 and MDA-MB-231).	Sulfhydryl Compounds	4-9	X-linked Kx blood group	Homo sapiens	44-47
15837323-2	2005	A series of heterocyclic mercaptans incorporating 1,3,4-thiadiazole- and 1,2,4-triazole rings have been prepared and assayed for the inhibition of three physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isozymes, the cytosolic human isozymes I and II, and the transmembrane, tumor-associated hCA IX.	Sulfhydryl Compounds	25-35	carbonic anhydrase 9	Homo sapiens	303-309
15837323-3	2005	Against hCA I the investigated thiols showed inhibition constants in the range of 97 nM to 548 microM, against hCA II in the range of 7.9-618 microM, and against hCA IX in the range of 9.3-772 microM.	Sulfhydryl Compounds	31-37	carbonic anhydrase 2	Homo sapiens	111-117
15837323-3	2005	Against hCA I the investigated thiols showed inhibition constants in the range of 97 nM to 548 microM, against hCA II in the range of 7.9-618 microM, and against hCA IX in the range of 9.3-772 microM.	Sulfhydryl Compounds	31-37	carbonic anhydrase 9	Homo sapiens	162-168
15626747-1	2005	Peroxiredoxins (Prxs) are a group of thiol containing proteins that participate both in signal transduction and in the breakdown of hydrogen peroxide (H(2)O(2)) during oxidative stress.	Sulfhydryl Compounds	37-42	peroxiredoxin 1	Homo sapiens	0-14
15850387-0	2005	The disulfide linkage and the free sulfhydryl accessibility of acyl-coenzyme A:cholesterol acyltransferase 1 as studied by using mPEG5000-maleimide.	Sulfhydryl Compounds	35-45	sterol O-acyltransferase 1	Homo sapiens	63-108
15890017-4	2005	Treatment of cells with NAC resulted in significant augmentation of intracellular small-molecular-weight thiols, glutathione and cysteine.	Sulfhydryl Compounds	105-111	X-linked Kx blood group	Homo sapiens	24-27
15877336-3	2005	Considering the size of the PL and their ability to form liposomes, 5 nm diameter spheres indicate that the PL bilayer was attached to the surface of Au particles and the PL-Au interactions are facilitated by the presence of thiol functionality.	Sulfhydryl Compounds	225-230	plasminogen activator, urokinase	Homo sapiens	171-176
15701387-0	2005	Reduction of silver solubility by humic acid and thiol ligands during acanthite (beta-Ag2S) dissolution.	Sulfhydryl Compounds	49-54	angiotensin II receptor type 1	Homo sapiens	86-90
15820482-1	2005	BACKGROUND: Albumin is a potent antioxidant as it chelates transitional metals and contains antioxidants like thiol and bilirubin.	Sulfhydryl Compounds	110-115	albumin	Homo sapiens	12-19
15808421-9	2005	Similarly, DEM and CDNB inhibited TNF-alpha-induced Akt and eNOS phosphorylation, suggesting that thiol modification is involved in eNOS inductive pathways.	Sulfhydryl Compounds	98-103	tumor necrosis factor	Homo sapiens	34-43
15808415-4	2005	Here we report the presence of trans lipids in human monocytic leukemia cell membranes (THP-1) before and after treatment with a 10 mM series of thiols.	Sulfhydryl Compounds	145-151	GLI family zinc finger 2	Homo sapiens	88-93
15808421-9	2005	Similarly, DEM and CDNB inhibited TNF-alpha-induced Akt and eNOS phosphorylation, suggesting that thiol modification is involved in eNOS inductive pathways.	Sulfhydryl Compounds	98-103	AKT serine/threonine kinase 1	Homo sapiens	52-55
15808421-9	2005	Similarly, DEM and CDNB inhibited TNF-alpha-induced Akt and eNOS phosphorylation, suggesting that thiol modification is involved in eNOS inductive pathways.	Sulfhydryl Compounds	98-103	nitric oxide synthase 3	Homo sapiens	60-64
15808421-9	2005	Similarly, DEM and CDNB inhibited TNF-alpha-induced Akt and eNOS phosphorylation, suggesting that thiol modification is involved in eNOS inductive pathways.	Sulfhydryl Compounds	98-103	nitric oxide synthase 3	Homo sapiens	132-136
15808421-10	2005	Our findings suggest that eNOS activation is exquisitely sensitive to regulation by redox and that cell surface thiols, other than glutathione, regulate signal transduction leading to phosphorylation of Akt and eNOS.	Sulfhydryl Compounds	112-118	AKT serine/threonine kinase 1	Homo sapiens	203-206
15808421-10	2005	Our findings suggest that eNOS activation is exquisitely sensitive to regulation by redox and that cell surface thiols, other than glutathione, regulate signal transduction leading to phosphorylation of Akt and eNOS.	Sulfhydryl Compounds	112-118	nitric oxide synthase 3	Homo sapiens	211-215
15840829-8	2005	The structure of CIB1 revealed a complex with a molecule of glutathione in the reduced state bond to the N-terminal domain of one of the two subunits poised to interact with the free thiol of C35.	Sulfhydryl Compounds	183-188	calcium and integrin binding 1	Homo sapiens	17-21
15828777-3	2005	The influence of the concentration of biotinylated thiol on the binding of biotinylated antibody and its functionality, in terms of its ability to bind to the hCG antigen, was studied.	Sulfhydryl Compounds	51-56	chorionic gonadotropin subunit beta 5	Homo sapiens	159-162
15828777-4	2005	This allowed determination of the optimum biotin-thiol mole fraction in the mixed thiol solution and consequently in the SAM, to maximize binding of hCG of the streptavidin-bound antibody.	Sulfhydryl Compounds	49-54	chorionic gonadotropin subunit beta 5	Homo sapiens	149-152
15695804-1	2005	Protein disulfide isomerase (PDI) functions as an isomerase to catalyze thiol:disulfide exchange, as a chaperone to assist protein folding, and as a subunit of prolyl-4-hydroxylase and microsomal triglyceride transfer protein.	Sulfhydryl Compounds	72-77	protein disulfide-isomerase	Oryctolagus cuniculus	0-27
15840388-4	2005	There are seven cysteine residues in human S-COMT, all of which exist as free thiols and are susceptible to electrophilic attack and/or oxidative damage leading to enzyme inactivation.	Sulfhydryl Compounds	78-84	catechol-O-methyltransferase	Homo sapiens	45-49
15695804-1	2005	Protein disulfide isomerase (PDI) functions as an isomerase to catalyze thiol:disulfide exchange, as a chaperone to assist protein folding, and as a subunit of prolyl-4-hydroxylase and microsomal triglyceride transfer protein.	Sulfhydryl Compounds	72-77	protein disulfide-isomerase	Oryctolagus cuniculus	29-32
15850984-3	2005	Several compounds showed high specificity for human TG2 (k(inh)/K(I) &gt; 2000 min(-1)M(-1)) but essentially no reactivity (k &lt; 1 min(-1)M(-1)) toward physiological thiols such as glutathione.	Sulfhydryl Compounds	168-174	transglutaminase 2	Homo sapiens	52-55
15805047-11	2005	Surprisingly, Hg alone enhanced the expression of this thiol-expressing protein, which by Mass Spectrometry (MS)/MS analysis was shown to be beta-actin.	Sulfhydryl Compounds	55-60	actin, beta	Mus musculus	141-151
15833036-5	2005	That ROS-driven thiol cross-linking underlies the CP aggregation was evidenced by the inhibitory effects of added superoxide dismutase, catalase, mannitol, and dithiothreitol.	Sulfhydryl Compounds	16-21	catalase	Homo sapiens	136-144
15536172-3	2005	Previous studies in the toad urinary bladder, a functional homologue of the renal collecting duct, have demonstrated that the sulfhydryl reagent N-ethylmaleimide (NEM) is also able to activate the vasopressin-sensitive water permeability pathway in this tissue.	Sulfhydryl Compounds	126-136	arginine vasopressin	Homo sapiens	197-208
15659399-7	2005	The low affinity component of LAT4 induced activity is sensitive to the sulfhydryl-specific reagent N-ethylmaleimide but not that with high affinity.	Sulfhydryl Compounds	72-82	solute carrier family 43 member 2	Homo sapiens	30-34
15811508-3	2005	A common path to the formation of SNO-Hb involves oxidative transfer of the NO-group from heme to thiol.	Sulfhydryl Compounds	98-103	strawberry notch homolog 1	Homo sapiens	34-37
15831216-7	2005	The small difference in structure between the two thiol-reactive conjugates (i.e., the C18 alkyl chain double bond) causes a considerable difference in phospholipids packing of the resulting lipidic bilayers of the liposomes; the conformational bending of conjugate maleimide-oleylamine may contribute to the final architecture of liposomes.	Sulfhydryl Compounds	50-55	Bardet-Biedl syndrome 9	Homo sapiens	87-90
15644496-6	2005	Here, using surface plasmon resonance, we observed an inverse relationship between heparin binding by gp120 and its thiol content.	Sulfhydryl Compounds	116-121	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	102-107
15736959-5	2005	Fluorescent labeling of the purified transporter with the thiol-reactive fluorophore nitrobenxoxadiazol-iodoacetamide (IANBD) and Texas Red bromoacetamide preserved the pharmacological profile of FLAG-hSERT-12H.	Sulfhydryl Compounds	58-63	solute carrier family 6 member 4	Homo sapiens	201-206
15767573-6	2005	The direct interaction of this TP with thiol groups of the Keap1 sensor for inducers is demonstrated spectroscopically.	Sulfhydryl Compounds	39-44	kelch-like ECH-associated protein 1	Mus musculus	59-64
15740133-6	2005	These functional polymers have been successfully employed in conjugation reactions in the presence of thiol-containing model substrates, namely, reduced glutathione (gamma-Glu-Cys-Gly) and the carrier protein, bovine serum albumin (BSA), in 100 mM phosphate buffer (pH 6.8-7.4) and ambient temperature.	Sulfhydryl Compounds	102-107	albumin	Homo sapiens	217-230
15653693-2	2005	Because cysteine residue(s) in IDPm are susceptible to inactivation by a number of thiol-modifying reagents, we hypothesized that IDPm is likely a target for regulation by an oxidative mechanism, specifically glutathionylation.	Sulfhydryl Compounds	83-88	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	31-35
15653693-2	2005	Because cysteine residue(s) in IDPm are susceptible to inactivation by a number of thiol-modifying reagents, we hypothesized that IDPm is likely a target for regulation by an oxidative mechanism, specifically glutathionylation.	Sulfhydryl Compounds	83-88	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	130-134
15727880-1	2005	A general synthesis of alpha-1-C-substituted derivatives of fagomine (2-deoxynojirimycin-alpha-C-glycosides) by ring-opening reactions of an aziridine with various heteroatomic nucleophiles, including thiol, amine, alcohol, carboxylate and phosphate, is described.	Sulfhydryl Compounds	201-206	adrenoceptor alpha 1D	Homo sapiens	23-30
15605380-10	2005	L-Methionine and L-cysteine, thiol-containing compounds metabolically related to homocysteine, acted only as weak inhibitors, reducing KYNA production in vitro and inhibiting the activity of KAT II (L-cysteine) or KAT I (L-methionine).	Sulfhydryl Compounds	29-34	kynurenine aminotransferase 1	Rattus norvegicus	191-196
15733082-3	2005	We now report that AD4, the novel low molecular weight thiol antioxidant and the N-acytel cysteine (NAC) related compound, is capable of penetrating the brain and protects neurons in general and especially dopaminergic cells against various OS-generating neurotoxins in tissue cultures.	Sulfhydryl Compounds	55-60	presenilin 2	Homo sapiens	19-22
15657297-3	2005	Here we show that CFTR channel activity in excised membrane patches is markedly inhibited by several oxidized forms of glutathione (i.e., GSSG, GSNO, and glutathione treated with diamide, a strong thiol oxidizer).	Sulfhydryl Compounds	197-202	CF transmembrane conductance regulator	Homo sapiens	18-22
15723974-0	2005	Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras.	Sulfhydryl Compounds	149-155	thioredoxin 1	Rattus norvegicus	99-112
15723974-9	2005	Although TRX1 can directly reduce thiols, it also can scavenge ROS by increasing peroxidase activity.	Sulfhydryl Compounds	34-40	thioredoxin 1	Rattus norvegicus	9-13
15723974-13	2005	CONCLUSIONS: AlphaAR-stimulated hypertrophic signaling in adult rat ventricular myocytes is mediated via a TRX1-sensitive posttranslational oxidative modification of thiols on Ras.	Sulfhydryl Compounds	166-172	thioredoxin 1	Rattus norvegicus	107-111
15788230-8	2005	Mass mapping experiments demonstrated the specific modification of peroxiredoxins active site thiol into sulphinic and/or sulphonic acid, thus explaining the increase in negative charge measured for these proteins.	Sulfhydryl Compounds	94-99	peroxiredoxin 1	Homo sapiens	67-81
15699178-9	2005	Finally, by using a thiol antioxidant, N-acetyl cysteine, we found that the suppression of IFN-gamma production by DEP-treated T cells was mediated by oxidative stress.	Sulfhydryl Compounds	20-25	interferon gamma	Homo sapiens	91-100
15649039-1	2005	A Pb(II)-specific DNAzyme fluorescent sensor has been modified with a thiol moiety in order to immobilize it on a Au surface.	Sulfhydryl Compounds	70-75	submaxillary gland androgen regulated protein 3B	Homo sapiens	2-8
15509664-6	2005	To evaluate modulation of LO expression by cellular thiols, we further examined the effect of increased levels of GSH on LO expression at protein and catalytic levels.	Sulfhydryl Compounds	52-58	lysyl oxidase	Rattus norvegicus	26-28
15509664-8	2005	These results suggest that upregulation by CSC of cellular thiols may play an important role in the downregulation of LO and subsequently destabilization of the lung ECM in CS-induced emphysema.	Sulfhydryl Compounds	59-65	lysyl oxidase	Rattus norvegicus	118-120
15670828-6	2005	The aim of the present study is to elucidate the role of DT-diaphorase in the protection against QQ-mediated thiol reactivity.	Sulfhydryl Compounds	109-114	NAD(P)H quinone dehydrogenase 1	Homo sapiens	57-70
15658862-3	2005	To evaluate this potential, we synthesized and characterized a series of low nanomolar nonpeptidic thiol-containing ECE-1 inhibitors, and evaluated their effect, as well as the effect of inhibitors for the related metalloproteases neprilysin (NEP; EC 3.4.24.11) and angiotensin-converting enzyme (ACE; EC 3.4.15.1), on human glioblastoma cell growth.	Sulfhydryl Compounds	99-104	endothelin converting enzyme 1	Homo sapiens	116-121
15620728-1	2005	We have investigated the effect of the sulfhydryl-reactive reagent, methyl thiosulfonate ethylammonium (MTSEA), on ligand binding to the human melanocortin-4 (MC4) receptor stably expressed in HEK-293 cells.	Sulfhydryl Compounds	39-49	melanocortin 4 receptor	Homo sapiens	143-172
16438288-16	2005	Treatment with a sulfhydryl donor compound (NAC) reduced acrylamide transformation while depletion of GSH (BSO) resulted in an enhancement of transformation.	Sulfhydryl Compounds	17-27	synuclein alpha	Homo sapiens	44-47
17282069-6	2005	On the other hand, treatement with realgar nanoparticles promoted the generations of reactive oxygen species (ROS) and inhibited the activity of catalase (CAT), which was accompanied by lipid peroxidation and protein oxidation, especially the loss of its free thiols, whereas such events was not observed in HL-60 cells exposed to raw realgar particles.	Sulfhydryl Compounds	260-266	catalase	Homo sapiens	155-158
15656582-4	2005	To optimize PEGylation, scFvs have been recombinantly produced in a vector that adds an unpaired cysteine (c) near the scFv carboxy terminus (scFv-c), thus providing a specific site for thiol conjugation.	Sulfhydryl Compounds	186-191	immunglobulin heavy chain variable region	Homo sapiens	24-28
16375256-4	2005	Unpaired cysteines were detected in omalizumab using Ellman"s reagent, with the thiol-containing Fab resolved using hydrophobic interaction chromatography after papain digestion.	Sulfhydryl Compounds	80-85	FA complementation group B	Homo sapiens	97-100
17282069-6	2005	On the other hand, treatement with realgar nanoparticles promoted the generations of reactive oxygen species (ROS) and inhibited the activity of catalase (CAT), which was accompanied by lipid peroxidation and protein oxidation, especially the loss of its free thiols, whereas such events was not observed in HL-60 cells exposed to raw realgar particles.	Sulfhydryl Compounds	260-266	catalase	Homo sapiens	145-153
15388652-7	2005	Thus, depletion of thiol antioxidants by BSO, like ovariectomy, causes bone loss through TNFalpha signaling.	Sulfhydryl Compounds	19-24	tumor necrosis factor	Mus musculus	89-97
15388652-8	2005	Furthermore, in ovariectomized mice treated with soluble TNFalpha receptors, thiol antioxidant defenses in bone remained low, despite inhibition of bone loss.	Sulfhydryl Compounds	77-82	tumor necrosis factor	Mus musculus	57-65
15388652-10	2005	These experiments are consistent with a model for estrogen-deficiency bone loss in which estrogen deficiency lowers thiol antioxidant defenses in bone cells, thereby increasing reactive oxygen species levels, which in turn induce expression of TNFalpha, which causes loss of bone.	Sulfhydryl Compounds	116-121	tumor necrosis factor	Mus musculus	244-252
15875806-3	2005	Submitted to the same treatment, the proliferative HL60 and THP-1 cells exhibited a high increase of ROS production, a moderate thiol depletion and a high percentage of apoptosis.	Sulfhydryl Compounds	128-133	GLI family zinc finger 2	Homo sapiens	60-65
15773552-7	2005	Then, in order to determine, whether RNS scavenging is implicated in the HOX-1 down-regulation by thiol antioxidants, we took advantage of the capacity of suboptimal concentrations of the NO scavenger PTIO (2-phenyl-4,4,5,5-tetramethylimidazole-1-oxyl-3-oxide) to oxidize NO to nitrosating species.	Sulfhydryl Compounds	98-103	heme oxygenase 1	Homo sapiens	73-78
15694701-11	2005	These thiol groups can, in turn, initiate a disulfide exchange reaction with plasma proteins, predominantly with fibrinogen, to form an insoluble and protease-resistant fibrin-like polymer.	Sulfhydryl Compounds	6-11	fibrinogen beta chain	Homo sapiens	113-123
16399404-3	2005	Through the action of these reactive compounds, cell membrane GGT activity can ultimately produce oxidative modifications on a variety of molecular targets, involving oxidation and/or S-thiolation of protein thiol groups in the first place.	Sulfhydryl Compounds	186-191	gamma-glutamyltransferase light chain family member 3	Homo sapiens	62-65
16399404-4	2005	This chapter is a survey of the procedures most suitable to reveal GGT-dependent prooxidant reactions and their effects at the cellular and extracellular level, including methods in histochemistry, cytochemistry, and biochemistry, with special reference to methods for the evaluation of protein thiol redox status.	Sulfhydryl Compounds	295-300	gamma-glutamyltransferase light chain family member 3	Homo sapiens	67-70
16291251-7	2005	The NO generated by mtNOS reacts with mitochondrial thiol-containing proteins including caspase-3.	Sulfhydryl Compounds	52-57	caspase 3	Homo sapiens	88-97
16338390-6	2005	In addition, preforming the Ub-E2 conjugate as an enzyme substrate for inhibitor screening minimizes interference from thiol-modifying compounds and from nucleotide analogs and other ATP-interfering compounds that might affect the E1 reaction.	Sulfhydryl Compounds	119-124	ubiquitin like modifier activating enzyme 7	Homo sapiens	28-33
15773552-1	2005	Previously it was shown that thiol antioxidants are potent inhibitors of the NO-dependent induction of heme oxygenase 1 (HOX-1) gene.	Sulfhydryl Compounds	29-34	heme oxygenase 1	Homo sapiens	103-119
15773552-1	2005	Previously it was shown that thiol antioxidants are potent inhibitors of the NO-dependent induction of heme oxygenase 1 (HOX-1) gene.	Sulfhydryl Compounds	29-34	heme oxygenase 1	Homo sapiens	121-126
15773552-2	2005	However, the mechanism of HOX-1 gene down-regulation by thiol antioxidants and underlying signaling pathway remain unclear.	Sulfhydryl Compounds	56-61	heme oxygenase 1	Homo sapiens	26-31
15773552-3	2005	In this study we have examined, whether the scavenging of reactive oxygen and reactive nitrogen species (ROS and RNS) is the major cause for thiol-mediated suppression of the HOX-1 induction by NO.	Sulfhydryl Compounds	141-146	heme oxygenase 1	Homo sapiens	175-180
15600341-1	2004	Artificial glutathione peroxidase (GPx) model 2, 2"-ditellurobis(2-deoxy-beta-cyclodextrin) (2-TeCD) which has the desirable properties exhibited high substrate specificity and remarkably catalytic efficiency when 3-carboxy-4-nitrobenzenethiol (ArSH) was used as a preferential thiol substrate.	Sulfhydryl Compounds	238-243	arylsulfatase family member H	Homo sapiens	245-249
16259044-9	2005	The findings that CP12 is able to bind a metal ion, and that Cu2+ catalyzes the oxidation of the thiol groups of CP12, are new characteristics of this protein that may prove to be important in the regulation of the assembly process of the PRK/GAPDH/CP12 complex.	Sulfhydryl Compounds	97-102	CP12 domain-containing protein 2	Arabidopsis thaliana	113-117
15612812-7	2004	Furthermore, thiol adducts at C-2 and C-2,5 of protocatechuic acid and its analogues were isolated from the reaction mixtures.	Sulfhydryl Compounds	13-18	complement C2	Homo sapiens	30-33
15612812-7	2004	Furthermore, thiol adducts at C-2 and C-2,5 of protocatechuic acid and its analogues were isolated from the reaction mixtures.	Sulfhydryl Compounds	13-18	complement C2	Homo sapiens	38-41
16259044-9	2005	The findings that CP12 is able to bind a metal ion, and that Cu2+ catalyzes the oxidation of the thiol groups of CP12, are new characteristics of this protein that may prove to be important in the regulation of the assembly process of the PRK/GAPDH/CP12 complex.	Sulfhydryl Compounds	97-102	CP12 domain-containing protein 2	Arabidopsis thaliana	113-117
15361410-3	2004	The apparent pKa of T338C CFTR was more acidic than that expected for a cysteine or similar simple thiols in aqueous solution.	Sulfhydryl Compounds	99-105	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	Xenopus laevis	26-30
15675819-3	2004	Heat treatment of milk causes the heat-denaturable whey proteins to aggregate with kappa-casein (kappa-CN) via thiol-disulfide bond interchange reactions.	Sulfhydryl Compounds	111-116	casein kappa	Bos taurus	97-105
15581364-4	2004	In the case of PPC-DC enzymes the resulting enethiol is reduced to a thiol giving net decarboxylation of cysteine, while in EpiD and MrsD it is released as the final product of the reaction.	Sulfhydryl Compounds	47-52	phosphopantothenoylcysteine decarboxylase	Homo sapiens	15-21
15581364-4	2004	In the case of PPC-DC enzymes the resulting enethiol is reduced to a thiol giving net decarboxylation of cysteine, while in EpiD and MrsD it is released as the final product of the reaction.	Sulfhydryl Compounds	47-52	MRSD	Homo sapiens	133-137
15646804-5	2004	Independently, the exposure of partially unfolded Tg to GSH resulted in Tg multimerization, enhanced by PDI, according to thiol-disulfide exchange.	Sulfhydryl Compounds	122-127	prolyl 4-hydroxylase subunit beta	Bos taurus	104-107
15675819-3	2004	Heat treatment of milk causes the heat-denaturable whey proteins to aggregate with kappa-casein (kappa-CN) via thiol-disulfide bond interchange reactions.	Sulfhydryl Compounds	111-116	casein kappa	Bos taurus	83-95
15659781-4	2004	The thiol-specific probe maleimide-polyethylene glycol was used to selectively label the reduced thiol groups in proteins of cell lysates; fractions corresponding to TNFR1 were then identified by immunoblot.	Sulfhydryl Compounds	4-9	TNF receptor superfamily member 1A	Homo sapiens	166-171
15545308-10	2004	This finding is not surprising based on the documented food effect with the sulfhydryl-containing ACE inhibitor, captopril.	Sulfhydryl Compounds	76-86	angiotensin I converting enzyme	Homo sapiens	98-101
15663198-5	2004	Thiol content was seen to increase significantly (p &lt; 0.05) in both RP-1 alone and RP-1 pretreated irradiated groups over the irradiated groups at 8, 16 and 24 h. Irradiation (10 Gy) significantly decreased GPx, GST and GR activity in comparison to untreated control but RP-1 treatment before irradiation significantly (p &lt; 0.05) countered radiation-induced decrease in the activity of these enzymes.	Sulfhydryl Compounds	0-5	retinitis pigmentosa 1 (human)	Mus musculus	71-75
15663198-5	2004	Thiol content was seen to increase significantly (p &lt; 0.05) in both RP-1 alone and RP-1 pretreated irradiated groups over the irradiated groups at 8, 16 and 24 h. Irradiation (10 Gy) significantly decreased GPx, GST and GR activity in comparison to untreated control but RP-1 treatment before irradiation significantly (p &lt; 0.05) countered radiation-induced decrease in the activity of these enzymes.	Sulfhydryl Compounds	0-5	retinitis pigmentosa 1 (human)	Mus musculus	86-90
15663198-5	2004	Thiol content was seen to increase significantly (p &lt; 0.05) in both RP-1 alone and RP-1 pretreated irradiated groups over the irradiated groups at 8, 16 and 24 h. Irradiation (10 Gy) significantly decreased GPx, GST and GR activity in comparison to untreated control but RP-1 treatment before irradiation significantly (p &lt; 0.05) countered radiation-induced decrease in the activity of these enzymes.	Sulfhydryl Compounds	0-5	retinitis pigmentosa 1 (human)	Mus musculus	86-90
15663198-11	2004	This study implies that RP-1 offers radioprotection at biochemical and cytogenetic level by protecting antioxidant enzymes, reducing LPO and increasing thiol content.	Sulfhydryl Compounds	152-157	retinitis pigmentosa 1 (human)	Mus musculus	24-28
15535964-1	2004	The recombinant human serum albumin (rHSA) dimer, which was cross-linked by a thiol group of Cys-34 with 1,6-bis(maleimido)hexane, has been physicochemically characterized.	Sulfhydryl Compounds	78-83	albumin	Rattus norvegicus	22-35
15653797-1	2004	Phytochelatin synthase (PCS) catalyzes the final step in the biosynthesis of phytochelatins, which are a family of cysteine-rich thiol-reactive peptides believed to play important roles in processing many thiol-reactive toxicants.	Sulfhydryl Compounds	129-134	phytochelatin synthase 1 (PCS1)	Arabidopsis thaliana	0-22
15653797-1	2004	Phytochelatin synthase (PCS) catalyzes the final step in the biosynthesis of phytochelatins, which are a family of cysteine-rich thiol-reactive peptides believed to play important roles in processing many thiol-reactive toxicants.	Sulfhydryl Compounds	205-210	phytochelatin synthase 1 (PCS1)	Arabidopsis thaliana	0-22
15653797-4	2004	After exposure to cadmium and arsenic, the overall accumulation of thiol-peptides increased to 10-fold higher levels in the A2::AtPCS1 plants compared with WT, as determined by fluorescent HPLC.	Sulfhydryl Compounds	67-72	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	128-134
15477007-7	2004	The inhibition of MKP-2 may have contributed to the enhancement observed by the thiol of mitogen-induced ERK phosphorylation.	Sulfhydryl Compounds	80-85	dual specificity phosphatase 4	Homo sapiens	18-23
15477009-8	2004	Cotreatment with thiol antioxidants decreased the ARE activity and Nrf2 protein level induced by DATS.	Sulfhydryl Compounds	17-22	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71
15347644-0	2004	Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE.	Sulfhydryl Compounds	98-103	glutaredoxin 2	Homo sapiens	0-14
15388247-2	2004	In addition to glutathione (GSH), thioredoxin (Trx) and thioredoxin reductase (TR) contain thiol groups and may react with electrophiles.	Sulfhydryl Compounds	91-96	thioredoxin	Cricetulus griseus	34-45
15388247-2	2004	In addition to glutathione (GSH), thioredoxin (Trx) and thioredoxin reductase (TR) contain thiol groups and may react with electrophiles.	Sulfhydryl Compounds	91-96	thioredoxin	Cricetulus griseus	47-50
15388247-2	2004	In addition to glutathione (GSH), thioredoxin (Trx) and thioredoxin reductase (TR) contain thiol groups and may react with electrophiles.	Sulfhydryl Compounds	91-96	thioredoxin	Cricetulus griseus	56-67
15347644-12	2004	Our findings indicate that Grx2 plays a central role in the response of mitochondria to both redox signals and oxidative stress by facilitating the interplay between the mitochondrial glutathione pool and protein thiols.	Sulfhydryl Compounds	213-219	glutaredoxin 2	Homo sapiens	27-31
15488859-5	2004	Homocysteine thiolactone and related molecules containing sulfhydryl groups (cysteine), but not methionine or homocystine (non-containing thiol-group) inhibited LOX.	Sulfhydryl Compounds	58-68	lysyl oxidase	Homo sapiens	161-164
15488859-5	2004	Homocysteine thiolactone and related molecules containing sulfhydryl groups (cysteine), but not methionine or homocystine (non-containing thiol-group) inhibited LOX.	Sulfhydryl Compounds	13-18	lysyl oxidase	Homo sapiens	161-164
15450951-4	2004	Thiol compounds, melatonin and rutin attenuated the MMC-induced nuclear damage, decrease in mitochondrial transmembrane potential, release of cytochrome c and activation of caspase-3.	Sulfhydryl Compounds	0-5	cytochrome c, somatic	Homo sapiens	142-154
15450951-4	2004	Thiol compounds, melatonin and rutin attenuated the MMC-induced nuclear damage, decrease in mitochondrial transmembrane potential, release of cytochrome c and activation of caspase-3.	Sulfhydryl Compounds	0-5	caspase 3	Homo sapiens	173-182
15605716-4	2004	Addition of a sulphydryl-oxidising agent, KlO3, to milk or whey increased HP-induced denaturation of beta-lg, but reduced the denaturation of alpha-la.	Sulfhydryl Compounds	14-24	beta-lactoglobulin	Bos taurus	101-108
15540944-9	2004	Additionally, Hsp72 was resistant to inactivation by the thiol-unreactive aldehyde malondialdehyde (MDA), further supporting a role for Cys in Hsp72 inhibition by 4-HNE.	Sulfhydryl Compounds	57-62	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	14-19
15605716-4	2004	Addition of a sulphydryl-oxidising agent, KlO3, to milk or whey increased HP-induced denaturation of beta-lg, but reduced the denaturation of alpha-la.	Sulfhydryl Compounds	14-24	lactalbumin alpha	Bos taurus	142-150
15605716-5	2004	Denaturation of both alpha-la and beta-lg was prevented by adding a sulphydryl-blocking agent, N-ethylmaleimide, to milk or whey prior to HP treatment, highlighting the crucial role of sulphydryl-disulphide interchange reactions in HP-induced denaturation of alpha-la and beta-lg.	Sulfhydryl Compounds	68-78	lactalbumin alpha	Bos taurus	21-29
15605716-5	2004	Denaturation of both alpha-la and beta-lg was prevented by adding a sulphydryl-blocking agent, N-ethylmaleimide, to milk or whey prior to HP treatment, highlighting the crucial role of sulphydryl-disulphide interchange reactions in HP-induced denaturation of alpha-la and beta-lg.	Sulfhydryl Compounds	68-78	beta-lactoglobulin	Bos taurus	34-41
15479833-0	2004	Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes.	Sulfhydryl Compounds	125-130	NFE2 like bZIP transcription factor 2	Homo sapiens	35-40
15479833-0	2004	Activation of transcription factor Nrf-2 and its downstream targets in response to moloney murine leukemia virus ts1-induced thiol depletion and oxidative stress in astrocytes.	Sulfhydryl Compounds	125-130	Trichinella spiralis resistance 1	Mus musculus	113-116
15479833-4	2004	We report here that ts1 infection of astrocytes (both transformed C1 cells and primary cultures) also induces thiol (i.e., glutathione and cysteine) depletion and reactive oxygen species (ROS) accumulation, events occurring in parallel with viral envelope precursor gPr80(env) accumulation and upregulated expression of endoplasmic reticulum chaperones GRP78 and GRP94.	Sulfhydryl Compounds	110-115	Trichinella spiralis resistance 1	Mus musculus	20-23
15479833-5	2004	Furthermore, ts1-infected astrocytes mobilize their thiol redox defenses by upregulating levels of the Nrf-2 transcription factor, as well its targets, the xCT cystine/glutamate antiporter, gamma-glutamylcysteine ligase, and glutathione peroxidase.	Sulfhydryl Compounds	52-57	Trichinella spiralis resistance 1	Mus musculus	13-16
15479833-5	2004	Furthermore, ts1-infected astrocytes mobilize their thiol redox defenses by upregulating levels of the Nrf-2 transcription factor, as well its targets, the xCT cystine/glutamate antiporter, gamma-glutamylcysteine ligase, and glutathione peroxidase.	Sulfhydryl Compounds	52-57	NFE2 like bZIP transcription factor 2	Homo sapiens	103-108
15479833-6	2004	Depleting intracellular thiols by treating uninfected astrocytes with buthionine sulfoximine (BSO), a glutathione synthesis inhibitor, or by culturing in cystine-deficient medium, also induces ROS accumulation, activates Nrf-2, and upregulates Nrf-2 target gene expression in these astrocytes.	Sulfhydryl Compounds	24-30	NFE2 like bZIP transcription factor 2	Homo sapiens	221-226
15479833-6	2004	Depleting intracellular thiols by treating uninfected astrocytes with buthionine sulfoximine (BSO), a glutathione synthesis inhibitor, or by culturing in cystine-deficient medium, also induces ROS accumulation, activates Nrf-2, and upregulates Nrf-2 target gene expression in these astrocytes.	Sulfhydryl Compounds	24-30	NFE2 like bZIP transcription factor 2	Homo sapiens	244-249
15479833-7	2004	Overexpression of Nrf-2 in astrocytes specifically increases expression of the above thiol synthesis-related proteins.	Sulfhydryl Compounds	85-90	NFE2 like bZIP transcription factor 2	Homo sapiens	18-23
15479833-9	2004	Thiol depletion also accelerates cell death, while thiol supplementation promotes survival of ts1-infected cells.	Sulfhydryl Compounds	51-56	Trichinella spiralis resistance 1	Mus musculus	94-97
15479833-10	2004	Together, our results indicate that ts1 infection of astrocytes, along with ts1-induced gPr80(env) accumulation, endoplasmic reticulum stress, thiol depletion, and oxidative stress, accelerates cell death; in response to the thiol depletion and oxidative stress, astrocytes activate their Nrf-2-mediated thiol antioxidant defenses, promoting cell survival.	Sulfhydryl Compounds	143-148	Trichinella spiralis resistance 1	Mus musculus	36-39
15479833-10	2004	Together, our results indicate that ts1 infection of astrocytes, along with ts1-induced gPr80(env) accumulation, endoplasmic reticulum stress, thiol depletion, and oxidative stress, accelerates cell death; in response to the thiol depletion and oxidative stress, astrocytes activate their Nrf-2-mediated thiol antioxidant defenses, promoting cell survival.	Sulfhydryl Compounds	225-230	Trichinella spiralis resistance 1	Mus musculus	36-39
15479833-10	2004	Together, our results indicate that ts1 infection of astrocytes, along with ts1-induced gPr80(env) accumulation, endoplasmic reticulum stress, thiol depletion, and oxidative stress, accelerates cell death; in response to the thiol depletion and oxidative stress, astrocytes activate their Nrf-2-mediated thiol antioxidant defenses, promoting cell survival.	Sulfhydryl Compounds	225-230	Trichinella spiralis resistance 1	Mus musculus	76-79
15479833-10	2004	Together, our results indicate that ts1 infection of astrocytes, along with ts1-induced gPr80(env) accumulation, endoplasmic reticulum stress, thiol depletion, and oxidative stress, accelerates cell death; in response to the thiol depletion and oxidative stress, astrocytes activate their Nrf-2-mediated thiol antioxidant defenses, promoting cell survival.	Sulfhydryl Compounds	225-230	Trichinella spiralis resistance 1	Mus musculus	36-39
15479833-10	2004	Together, our results indicate that ts1 infection of astrocytes, along with ts1-induced gPr80(env) accumulation, endoplasmic reticulum stress, thiol depletion, and oxidative stress, accelerates cell death; in response to the thiol depletion and oxidative stress, astrocytes activate their Nrf-2-mediated thiol antioxidant defenses, promoting cell survival.	Sulfhydryl Compounds	225-230	Trichinella spiralis resistance 1	Mus musculus	76-79
15624308-9	2004	This delayed radioprotective effect correlated with elevated Sod2 protein levels in wild-type SA-NH tumor cells but was not observed in SA-NH+mIkappaBalpha1 cells, indicating that interference with thiol-induced NFKB activation abrogates this delayed radioprotective effect.	Sulfhydryl Compounds	198-203	superoxide dismutase 2	Homo sapiens	61-65
15501401-6	2004	Increasing either dithiothreitol or reduced glutathione (GSH) content of the phosphorylation buffer to protect thiol groups blocks NO inhibition of IGF-RK substrate phosphorylation.	Sulfhydryl Compounds	111-116	insulin like growth factor 1	Homo sapiens	148-151
15624308-0	2004	Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.	Sulfhydryl Compounds	126-131	nuclear factor kappa B subunit 1	Homo sapiens	27-35
15624308-0	2004	Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.	Sulfhydryl Compounds	126-131	superoxide dismutase 2	Homo sapiens	58-62
15502869-9	2004	We discovered a substantial number of redox-sensitive cytoplasmic proteins, whose thiol groups were significantly oxidized in strains lacking thioredoxin A.	Sulfhydryl Compounds	82-87	thioredoxin	Homo sapiens	142-153
15502869-11	2004	H(2)O(2)-induced oxidative stress resulted in the specific oxidation of thiols of proteins involved in detoxification of H(2)O(2) and of enzymes of cofactor and amino acid biosynthesis pathways such as thiolperoxidase, GTP-cyclohydrolase I, and the cobalamin-independent methionine synthase MetE.	Sulfhydryl Compounds	72-78	GTP cyclohydrolase 1	Homo sapiens	219-239
15624308-0	2004	Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs.	Sulfhydryl Compounds	126-131	superoxide dismutase 2	Homo sapiens	64-69
15624308-10	2004	Because the delayed radioprotective effect is readily demonstrable at a radiation dose of 2 Gy 24 h after exposure to clinically approved thiol-containing drugs such as amifostine, captopril, mesna and NAC, it suggests a new potential concern regarding the issue of tumor protection and the use of these agents in cancer therapy.	Sulfhydryl Compounds	138-143	X-linked Kx blood group	Homo sapiens	202-205
15624308-2	2004	Manganese superoxide dismutase (Sod2) is one such gene whose expression levels have been shown to be elevated after exposure to the thiol compounds WR-1065 and N-acetyl-L-cysteine (NAC), resulting in an increase in radiation resistance.	Sulfhydryl Compounds	132-137	superoxide dismutase 2	Homo sapiens	32-36
15624308-2	2004	Manganese superoxide dismutase (Sod2) is one such gene whose expression levels have been shown to be elevated after exposure to the thiol compounds WR-1065 and N-acetyl-L-cysteine (NAC), resulting in an increase in radiation resistance.	Sulfhydryl Compounds	132-137	X-linked Kx blood group	Homo sapiens	181-184
15666550-0	2004	Thiol-reactive clenbuterol analogues conjugated to bovine serum albumin.	Sulfhydryl Compounds	0-5	albumin	Homo sapiens	58-71
15624308-3	2004	To further characterize this effect, SA-NH sarcoma cells, both wild-type and a clone stably transfected with a plasmid containing an IkappaBalpha gene mutated at serines 32 and 36, which prevents the inducible phosphorylation of these residues and the subsequent activation of NFkappaB (SA-NH+mIkappaBalpha1), were grown to confluence and then exposed to amifostine"s free thiol WR-1065 at a concentration of 4 mM for 30 min.	Sulfhydryl Compounds	373-378	NFKB inhibitor alpha	Homo sapiens	133-145
15624308-8	2004	All four thiols were protective if irradiation with 2 Gy occurred 24 h later; i.e. increases in survival of 1.40, 1.22, 1.35, and 1.25 times were found for WR-1065, captopril, mesna and NAC, respectively.	Sulfhydryl Compounds	9-15	X-linked Kx blood group	Homo sapiens	186-189
15504453-1	2004	Mammalian porphobilinogen synthase (PBGS) is a metalloenzyme, which requires Zn2+ and reduced thiol groups for maximal catalytic activity, and is an important molecular target for the widespread environmental toxic metals.	Sulfhydryl Compounds	94-99	aminolevulinate dehydratase	Bos taurus	10-34
15504453-1	2004	Mammalian porphobilinogen synthase (PBGS) is a metalloenzyme, which requires Zn2+ and reduced thiol groups for maximal catalytic activity, and is an important molecular target for the widespread environmental toxic metals.	Sulfhydryl Compounds	94-99	aminolevulinate dehydratase	Bos taurus	36-40
15282410-2	2004	The glutathione (GSH) and thioredoxin (TRX) systems have overlapping functions in thiol/disulfide redox control in both the cytoplasm and the nucleus, and it is unclear whether these are redundant or have unique functions in control of Nrf-2-dependent signaling.	Sulfhydryl Compounds	82-87	thioredoxin	Homo sapiens	26-37
15282410-2	2004	The glutathione (GSH) and thioredoxin (TRX) systems have overlapping functions in thiol/disulfide redox control in both the cytoplasm and the nucleus, and it is unclear whether these are redundant or have unique functions in control of Nrf-2-dependent signaling.	Sulfhydryl Compounds	82-87	thioredoxin	Homo sapiens	39-42
15666550-1	2004	Several novel thiol-reactive clenbuterol analogues were coupled in high yield with bovine serum albumin (BSA).	Sulfhydryl Compounds	14-19	albumin	Homo sapiens	90-103
15245329-11	2004	The interaction of Bcl-2D21 with SERCA resulted in a conformational transition of SERCA, assessed through a Bcl-2-dependent increase in SERCA thiols available for the labelling with a fluorescent reagent.	Sulfhydryl Compounds	142-148	BCL2 apoptosis regulator	Homo sapiens	19-24
15464274-0	2004	Thimerosal decreases TRPV1 activity by oxidation of extracellular sulfhydryl residues.	Sulfhydryl Compounds	66-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-26
15464274-5	2004	These results suggest that the modification of an extracellular thiol group can alter the activity of TRPV1.	Sulfhydryl Compounds	64-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
15245329-11	2004	The interaction of Bcl-2D21 with SERCA resulted in a conformational transition of SERCA, assessed through a Bcl-2-dependent increase in SERCA thiols available for the labelling with a fluorescent reagent.	Sulfhydryl Compounds	142-148	BCL2 apoptosis regulator	Homo sapiens	108-113
15272010-6	2004	We first mapped potential contact points in wild-type CFTR by cysteine mutagenesis and thiol cross-linking analysis.	Sulfhydryl Compounds	87-92	CF transmembrane conductance regulator	Homo sapiens	54-58
15351727-6	2004	The increase in SULT1A1 activity did not correlate with protein (Western blot) or mRNA (RT-PCR) results but correlated well with increased non-protein soluble thiols.	Sulfhydryl Compounds	159-165	sulfotransferase family 1A member 1	Rattus norvegicus	16-23
15487891-8	2004	To investigate the regulatory mechanism of protein function by S-oxidation/thiolation, the binding of a low molecular weight thiol (glutathione) to a glycolytic enzyme alpha-enolase was characterized.	Sulfhydryl Compounds	75-80	enolase 1	Homo sapiens	168-181
15292529-11	2004	BASDAI was positively correlated with VAS, ESR and CRP; but MPO was negatively correlated with thiol/albumin ratio, both in total and active AS patients.	Sulfhydryl Compounds	95-100	myeloperoxidase	Homo sapiens	60-63
15351709-3	2004	Oxidation and reduction of cysteines in tau and microtubule-associated protein-2 were quantitated by monitoring the incorporation of 5-iodoacetamido-fluorescein, a thiol-specific labeling reagent.	Sulfhydryl Compounds	164-169	microtubule associated protein 2	Homo sapiens	48-80
15351291-10	2004	These aspects should make substrates of this type generally applicable for assaying PDI and other thiol-disulfide exchange enzymes.	Sulfhydryl Compounds	98-103	prolyl 4-hydroxylase subunit beta	Homo sapiens	84-87
15379556-1	2004	Thioredoxin reductase 1 (TR1) is a key component in the thioredoxin system, one of major redox systems in mammals that links NADPH and thiol-dependent processes.	Sulfhydryl Compounds	135-140	thioredoxin reductase 1	Homo sapiens	0-23
15379556-1	2004	Thioredoxin reductase 1 (TR1) is a key component in the thioredoxin system, one of major redox systems in mammals that links NADPH and thiol-dependent processes.	Sulfhydryl Compounds	135-140	thioredoxin reductase 1	Homo sapiens	25-28
15379556-1	2004	Thioredoxin reductase 1 (TR1) is a key component in the thioredoxin system, one of major redox systems in mammals that links NADPH and thiol-dependent processes.	Sulfhydryl Compounds	135-140	thioredoxin	Homo sapiens	56-67
15343403-10	2004	Antibodies for SMN were then coupled to the sensor with the pre-activated thiol.	Sulfhydryl Compounds	74-79	survival of motor neuron 1, telomeric	Homo sapiens	15-18
15339153-3	2004	The thiols further spread on the metal surface, forming highly ordered SAMs in the form of a ring pattern.	Sulfhydryl Compounds	4-10	methionine adenosyltransferase 1A	Homo sapiens	71-75
15314233-4	2004	We screened a library of 10,000 thiol-containing compounds against accessible cysteines of two members of the caspase family of proteases, caspase-3 and -7.	Sulfhydryl Compounds	32-37	caspase 3	Homo sapiens	139-155
15175016-3	2004	We found that N-ethylmaleimide, which selectively alkylates free thiol groups of cysteine residues, completely inhibited the kinase activity of PDGFR-beta.	Sulfhydryl Compounds	65-70	platelet derived growth factor receptor beta	Homo sapiens	144-154
15315393-5	2004	3,5-DiCQA and 5-CQA with an apple acetone powder (AP) containing polyphenol oxidase showed high capturing activities toward thiols, and two addition compounds between 3,5-diCQA and methane thiol were also identified.	Sulfhydryl Compounds	124-130	polyphenol oxidase, chloroplastic	Malus domestica	65-83
15151929-10	2004	PTP activity, measured by using p-nitrophenyl phosphate as a substrate, was significantly higher in the caput spermatozoa (high thiol content) than in the cauda spermatozoa (low thiol content).	Sulfhydryl Compounds	128-133	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	0-3
15151929-10	2004	PTP activity, measured by using p-nitrophenyl phosphate as a substrate, was significantly higher in the caput spermatozoa (high thiol content) than in the cauda spermatozoa (low thiol content).	Sulfhydryl Compounds	178-183	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	0-3
15151929-11	2004	Our results show that PTP activity is correlated with sperm thiol status and suggest that tyrosine phosphorylation of sperm proteins during sperm maturation is promoted by thiol oxidation and diminished PTP.	Sulfhydryl Compounds	60-65	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	22-25
15151929-11	2004	Our results show that PTP activity is correlated with sperm thiol status and suggest that tyrosine phosphorylation of sperm proteins during sperm maturation is promoted by thiol oxidation and diminished PTP.	Sulfhydryl Compounds	172-177	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	22-25
15197184-5	2004	In this report, RyR1-enriched junctional sarcoplasmic reticulum is labeled with 7-diethylamino-3-(4"-maleimidylphenyl)-4-methylcoumarin (CPM, 1 pmol/microg of protein) in the presence of 10 mm Mg(2+), conditions previously shown to selectively label hyperreactive sulfhydryls and eliminate redox sensing.	Sulfhydryl Compounds	264-275	ryanodine receptor 1	Homo sapiens	16-20
15246877-1	2004	In the present study, we have investigated S-nitrosation of reactive thioredoxin (Trx) thiol groups in nitric oxide/superoxide system.	Sulfhydryl Compounds	87-92	thioredoxin	Homo sapiens	69-80
15246877-1	2004	In the present study, we have investigated S-nitrosation of reactive thioredoxin (Trx) thiol groups in nitric oxide/superoxide system.	Sulfhydryl Compounds	87-92	thioredoxin	Homo sapiens	82-85
15246877-2	2004	We have found that Trx thiol groups are the targets for S-nitrosation by N2O3-like species generated in the system containing xanthine/xanthine oxidase (superoxide producing system) and DEA/NO-the *NO donating compound, however, they have shown low sensitivity to the *NO derived from DEA/NO.	Sulfhydryl Compounds	23-28	thioredoxin	Homo sapiens	19-22
15212948-10	2004	Furthermore, UV-induced JNK activation was blocked by NEM, a sulfhydryl alkylating agent also affecting K(+) current.	Sulfhydryl Compounds	61-71	mitogen-activated protein kinase 8	Homo sapiens	24-27
15499198-2	2004	HSA, purified from either healthy subjects or renal failure patients, was incubated with NAC in buffer and analyzed by 4VP-EG-Me column chromatography, which can distinguish between the redox states of the only free thiol of HSA.	Sulfhydryl Compounds	216-221	albumin	Homo sapiens	0-3
15169922-7	2004	In addition, we demonstrated a statistically significant increase of detectable free thiol groups in the sperm mid- and principle piece in isolated rat sperm after stimulation with MIF at concentrations of 25 and 50 ng/ml.	Sulfhydryl Compounds	85-90	macrophage migration inhibitory factor	Rattus norvegicus	181-184
15289318-4	2004	We examined the effect of dietary supplementation with the thiol-containing antioxidant N-acetyl-l-cysteine (NAC) on levels of oxidative DNA damage and the frequency of DNA deletions in Atm-deficient (AT-mutated) mice.	Sulfhydryl Compounds	59-64	ataxia telangiectasia mutated	Mus musculus	186-189
15180957-8	2004	A circuitry model incorporating cysteine as a redox node, along with Trx1 and GSH, reveals how selective interactions between the different thiol/disulfide couples and reactive protein thiols could differentially regulate metabolic functions.	Sulfhydryl Compounds	140-145	thioredoxin	Homo sapiens	69-73
15180957-8	2004	A circuitry model incorporating cysteine as a redox node, along with Trx1 and GSH, reveals how selective interactions between the different thiol/disulfide couples and reactive protein thiols could differentially regulate metabolic functions.	Sulfhydryl Compounds	185-191	thioredoxin	Homo sapiens	69-73
15286141-10	2004	Key transcripts encoding antioxidative enzymes were much less affected, although glutathione synthetase was suppressed by feeding thiols or GSSG.	Sulfhydryl Compounds	130-136	glutathione synthetase	Homo sapiens	81-103
15159384-8	2004	We postulate that plastid cytochrome c maturation requires CCDA, thioredoxin HCF164, and other molecules in a membrane-associated trans-thylakoid thiol-reducing pathway.	Sulfhydryl Compounds	146-151	Cytochrome c	Arabidopsis thaliana	26-38
15159384-8	2004	We postulate that plastid cytochrome c maturation requires CCDA, thioredoxin HCF164, and other molecules in a membrane-associated trans-thylakoid thiol-reducing pathway.	Sulfhydryl Compounds	146-151	thioredoxin H-type 1	Arabidopsis thaliana	65-76
15203191-16	2004	Blocking TGF-beta1-induced gene expression by modulating cellular redox status with thiols can be potentially beneficial for treating arthritic and other disorders caused by excessive TGF-beta1.	Sulfhydryl Compounds	84-90	transforming growth factor beta 1	Homo sapiens	9-18
15203191-16	2004	Blocking TGF-beta1-induced gene expression by modulating cellular redox status with thiols can be potentially beneficial for treating arthritic and other disorders caused by excessive TGF-beta1.	Sulfhydryl Compounds	84-90	transforming growth factor beta 1	Homo sapiens	184-193
15240658-2	2004	Within this pathway, IFN-gamma-inducible lysosomal thiol reductase (GILT) functions to catalyze thiol bond reduction, thus unfolding native protein Ag and facilitating further processing via cellular proteases.	Sulfhydryl Compounds	51-56	IFI30 lysosomal thiol reductase	Homo sapiens	68-72
15271348-4	2004	Herein, we describe the chemical introduction of reactive thiol groups onto Pan10, the specific conjugation of the modified scFv to maleimide-derivatized analogs of the potent cytotoxic agent duocarmycin SA, and the properties of the resultant conjugates.	Sulfhydryl Compounds	58-63	NLR family pyrin domain containing 11	Homo sapiens	76-81
15237985-1	2004	Heterodisulfide reductase (Hdr) from methanogenic archea is an iron-sulfur protein that catalyzes the reversible two-electron reduction of the mixed disulfide CoM-S-S-CoB to the thiol coenzymes, coenzyme M (CoM-SH) and coenzyme B (CoB-SH).	Sulfhydryl Compounds	178-183	metabolism of cobalamin associated B	Homo sapiens	167-170
15318812-2	2004	To investigate the reactivity of PDI with thiol modifiers at low physiological pHs, either the reduced (PDIred) or oxidized form (PDIoxid) of PDI was exposed to various alkylating ragents.	Sulfhydryl Compounds	42-47	prolyl 4-hydroxylase subunit beta	Homo sapiens	33-36
15132975-5	2004	Oxidation of critical thiol groups by MPTP disrupts mitochondrial complex I, and up-regulation of glutaredoxin (a thiol disulfide oxidoreductase) is essential for recovery of complex I.	Sulfhydryl Compounds	22-27	glutaredoxin	Mus musculus	98-110
15138890-7	2004	Twenty genes, including AGS1 (alpha-1,3-glucan synthase) and TSA1 (thiol-specific antioxidant), were shown to be more highly expressed in the yeast cells than in the hyphae.	Sulfhydryl Compounds	67-72	ubiquitin-binding ESCRT-I subunit protein STP22	Saccharomyces cerevisiae S288C	24-28
15138890-7	2004	Twenty genes, including AGS1 (alpha-1,3-glucan synthase) and TSA1 (thiol-specific antioxidant), were shown to be more highly expressed in the yeast cells than in the hyphae.	Sulfhydryl Compounds	67-72	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	61-65
15186099-3	2004	The purified glycinin from soybean in the adverse conditions was associated with a significant amount of sugar and showed reductions in hydrophobic interactions after 3 months; the total free sulfhydryl content in glycinin decreased, but the intramolecular disulfide bonds increased; the alpha-helix content of secondary structure slightly increased, but the beta-sheet content decreased.	Sulfhydryl Compounds	192-202	LOC732636	Glycine max	13-21
15193566-1	2004	The thioredoxin and glutathione systems play a central role in thiol-disulfide redox homeostasis in many organisms by providing electrons to essential enzymes, and defence against oxidative stress.	Sulfhydryl Compounds	63-68	thioredoxin	Homo sapiens	4-15
15212484-2	2004	HRGS treatment of myofibrils caused cross-linking of myosin heavy chains (MHC) via disulfide bonding, an increase in Ca-ATPase activity, and a decrease in K-ATPase activity, suggesting that thiol groups of myosin including those at the active site were modified.	Sulfhydryl Compounds	190-195	myosin, heavy chain 11, smooth muscle	Gallus gallus	53-72
15186099-3	2004	The purified glycinin from soybean in the adverse conditions was associated with a significant amount of sugar and showed reductions in hydrophobic interactions after 3 months; the total free sulfhydryl content in glycinin decreased, but the intramolecular disulfide bonds increased; the alpha-helix content of secondary structure slightly increased, but the beta-sheet content decreased.	Sulfhydryl Compounds	192-202	LOC732636	Glycine max	214-222
15031284-3	2004	In this study, a variant of full-length PrP with an unpaired cysteine at the C terminus was recombinantly produced in Escherichia coli, covalently coupled to a thiol-reactive phospholipid, and incorporated into liposomes to serve as a model for studying possible changes in structure and stability of recombinant PrP upon membrane attachment.	Sulfhydryl Compounds	160-165	prion protein	Homo sapiens	40-43
15182179-6	2004	The largest effect on the steady-state kinetics was observed with the C315 single mutants, in which substitution of the thiol group resulted in a reduced k(cat) (to 26-33% of that of wild-type hBCATm).	Sulfhydryl Compounds	120-125	branched chain amino acid transaminase 2	Homo sapiens	193-199
15187432-0	2004	Comparative study of the inhibition of metallo-beta-lactamases (IMP-1 and VIM-2) by thiol compounds that contain a hydrophobic group.	Sulfhydryl Compounds	84-89	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	64-69
15135304-5	2004	Sodium selenite and Ebselen stimulated the skeletal muscle ryanodine receptor by oxidizing 14 of 47 free thiols per monomer on RyR1 (as detected with the alkylating agent 7-diethylamino-3-(4"-maleimidylphenyl)-4-methylcoumarin) (CPM).	Sulfhydryl Compounds	105-111	ryanodine receptor 1	Oryctolagus cuniculus	43-77
15135304-5	2004	Sodium selenite and Ebselen stimulated the skeletal muscle ryanodine receptor by oxidizing 14 of 47 free thiols per monomer on RyR1 (as detected with the alkylating agent 7-diethylamino-3-(4"-maleimidylphenyl)-4-methylcoumarin) (CPM).	Sulfhydryl Compounds	105-111	ryanodine receptor 1	Oryctolagus cuniculus	127-131
15147840-8	2004	To reduce this buried Cys10-Cys15 disulphide-bridge in double oxidized ArsC, an intra-molecular Cys10-Cys82 disulphide switch connects the thioredoxin mediated inter-protein thiol-disulphide transfer to the buried disulphide.	Sulfhydryl Compounds	174-179	arsenate reductase	Staphylococcus aureus	71-75
15147840-8	2004	To reduce this buried Cys10-Cys15 disulphide-bridge in double oxidized ArsC, an intra-molecular Cys10-Cys82 disulphide switch connects the thioredoxin mediated inter-protein thiol-disulphide transfer to the buried disulphide.	Sulfhydryl Compounds	174-179	AT695_RS07555	Staphylococcus aureus	139-150
15187432-0	2004	Comparative study of the inhibition of metallo-beta-lactamases (IMP-1 and VIM-2) by thiol compounds that contain a hydrophobic group.	Sulfhydryl Compounds	84-89	vimentin 2, pseudogene	Homo sapiens	74-79
15147359-7	2004	In the whole study group, we found a correlation (multiple R 0.5, P &lt; 0.001) of CD23(+)CD25(+) cells with blood counts of monocytes, CD4(+)CD8(+) cells, CD25(+) cells, basal haemolysis and plasma levels of thiols.	Sulfhydryl Compounds	209-215	Fc epsilon receptor II	Homo sapiens	83-87
15110152-6	2004	This review focuses on current research toward understanding the control of the isolated cardiac Ca(2+) release channel/ryanodine receptor (RyR2) by Ca(2+), calmodulin, thiol oxidation/reduction and nitrosylation, and protein phosphorylation.	Sulfhydryl Compounds	169-174	ryanodine receptor 2	Homo sapiens	140-144
15147359-7	2004	In the whole study group, we found a correlation (multiple R 0.5, P &lt; 0.001) of CD23(+)CD25(+) cells with blood counts of monocytes, CD4(+)CD8(+) cells, CD25(+) cells, basal haemolysis and plasma levels of thiols.	Sulfhydryl Compounds	209-215	interleukin 2 receptor subunit alpha	Homo sapiens	90-94
15147922-7	2004	In vitro, Na(2)SeO(3) did not prevent mercury effects, but potentiated ALA-D inhibition by mercury, probably due to its ability to oxidize thiol groups.	Sulfhydryl Compounds	139-144	aminolevulinate dehydratase	Rattus norvegicus	71-76
15147215-3	2004	This free thiol plays an important role in the heat-induced aggregation of BLG and, possibly, in its conformational stability.	Sulfhydryl Compounds	10-15	beta-lactoglobulin	Bos taurus	75-78
15109915-2	2004	Here we test the hypothesis that glutaredoxin-1 (Grx-1), a member of the oxidoreductase family of enzymes, may be a critical component of redox-sensitive molecular switches by mediating reversible protein S-glutathionylation and enzymatic catalysis of thiol/disulfide exchange.	Sulfhydryl Compounds	252-257	glutaredoxin	Homo sapiens	33-47
15109915-2	2004	Here we test the hypothesis that glutaredoxin-1 (Grx-1), a member of the oxidoreductase family of enzymes, may be a critical component of redox-sensitive molecular switches by mediating reversible protein S-glutathionylation and enzymatic catalysis of thiol/disulfide exchange.	Sulfhydryl Compounds	252-257	glutaredoxin	Homo sapiens	49-54
15147565-9	2004	In contrast, a thiol antioxidant, N-acetyl-l-cysteine, completely blocked X-irradiation-induced up-regulation of CD80 expression in LPS-B cells, but not in A20-HL cells or in DCs.	Sulfhydryl Compounds	15-20	CD80 antigen	Mus musculus	113-117
15135170-8	2004	Kinetic analysis of the formation of the various free radicals suggests that tryptophanyl radical and tyrosyl radical formation are independent events, and that formation of the Cys-110 thiyl radical on human myoglobin occurs via oxidation of the thiol group by the Tyr-103 phenoxyl radical.	Sulfhydryl Compounds	247-252	myoglobin	Homo sapiens	209-218
15149601-1	2004	In healthy cells the antiapoptotic protein Bcl-2 adopts a topology typical of tail-anchored proteins with only the hydrophobic carboxyl terminus inserted into the membrane, as shown by labeling cell lysates with a membrane-impermeant sulfhydryl-specific reagent.	Sulfhydryl Compounds	234-244	BCL2 apoptosis regulator	Homo sapiens	43-48
15039483-6	2004	Interestingly, several thiol antioxidative genes (glutathione peroxidase 1, peroxiredoxin 6, and thioredoxin 2) were found by microarray and confirmed by real-time PCR to be upregulated by high glucose.	Sulfhydryl Compounds	23-28	glutathione peroxidase 1	Homo sapiens	50-74
15039483-6	2004	Interestingly, several thiol antioxidative genes (glutathione peroxidase 1, peroxiredoxin 6, and thioredoxin 2) were found by microarray and confirmed by real-time PCR to be upregulated by high glucose.	Sulfhydryl Compounds	23-28	peroxiredoxin 6	Homo sapiens	76-91
15039483-6	2004	Interestingly, several thiol antioxidative genes (glutathione peroxidase 1, peroxiredoxin 6, and thioredoxin 2) were found by microarray and confirmed by real-time PCR to be upregulated by high glucose.	Sulfhydryl Compounds	23-28	thioredoxin 2	Homo sapiens	97-110
15137749-4	2004	The results suggest an additional dimension in the control of structure and properties of thiol monolayers if different factors contributing to the energetics of SAMs enter in a competing rather than a cooperative way.	Sulfhydryl Compounds	90-95	methionine adenosyltransferase 1A	Homo sapiens	162-166
15007512-0	2004	Effect of thiol antioxidant on body fat and insulin reactivity.	Sulfhydryl Compounds	10-15	insulin	Homo sapiens	44-51
15099742-5	2004	Recombinant CePrx2 revealed antioxidant activity, as it was able to detoxify hydrogen peroxide and butylhydroperoxide (t-BOOH), and to protect glutamine synthetase from inactivation by thiol-dependent metal-catalyzed oxidation.	Sulfhydryl Compounds	185-190	RING-type domain-containing protein	Caenorhabditis elegans	12-18
15250541-7	2004	The reversal by DTT suggested that mercury caused the decrease of GR binding activity by interacting with thiol groups.	Sulfhydryl Compounds	106-111	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	66-68
15250541-9	2004	The implicated thiols probably belong to GR, since when applied in vitro at 0 degrees C, mercury produced reduction of the receptor binding activity similar to that observed in vivo.	Sulfhydryl Compounds	15-21	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	41-43
15204636-4	2004	The optimal vector, designated PT-cAu-TNF, consists of molecules of thiol-derivatized PEG (PT) and recombinant human TNF that are directly bound onto the surface of the gold nanoparticles.	Sulfhydryl Compounds	68-73	tumor necrosis factor	Homo sapiens	38-41
14996837-7	2004	In vitro assays with purified protein and artificial substrates demonstrate a preference of AtErv1 for dithiols with a defined space between the thiol groups, suggesting a thioredoxin-like substrate.	Sulfhydryl Compounds	105-110	Erv1/Alr family protein	Arabidopsis thaliana	92-98
14695120-2	2004	Thioredoxin (Trx) is a protein disulfide reductase that catalyzes numerous thiol-dependent cellular reductive processes.	Sulfhydryl Compounds	75-80	thioredoxin	Homo sapiens	0-11
14695120-2	2004	Thioredoxin (Trx) is a protein disulfide reductase that catalyzes numerous thiol-dependent cellular reductive processes.	Sulfhydryl Compounds	75-80	thioredoxin	Homo sapiens	13-16
15096212-6	2004	The results show that disulfide reshuffling is easier to induce in HPI than in PIP by the addition of thiol reagent.	Sulfhydryl Compounds	102-107	prolactin induced protein	Homo sapiens	79-82
14871896-3	2004	Here we have characterized several fundamental structural and functional properties of ERp57 in vitro, such as the domain organization, shape, redox potential, and the ability to catalyze different thiol-disulfide exchange reactions.	Sulfhydryl Compounds	198-203	protein disulfide isomerase family A member 3	Homo sapiens	87-92
14747470-6	2004	Other thiol-containing compounds, including l-homocysteine thiolactone and DTT, induced VEGF expression 7.9- and 8.8-fold.	Sulfhydryl Compounds	6-11	vascular endothelial growth factor A	Homo sapiens	88-92
15063339-1	2004	D-Penicillamine (D-Pen) is a thiol drug used in the treatment of Wilson"s disease, rheumatoid arthritis, metal intoxication and cystinuria.	Sulfhydryl Compounds	29-34	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	2-5
14747470-12	2004	These studies indicate that expression of the pro-angiogenic factor VEGF is increased by homocysteine and other thiol-containing reductive compounds via ATF4-dependent activation of VEGF transcription.	Sulfhydryl Compounds	112-117	vascular endothelial growth factor A	Homo sapiens	68-72
14747474-7	2004	Furthermore, thiol reductant thioredoxin blocked the caspase-9 activation step and the cell death induction.	Sulfhydryl Compounds	13-18	thioredoxin	Homo sapiens	29-40
14747470-12	2004	These studies indicate that expression of the pro-angiogenic factor VEGF is increased by homocysteine and other thiol-containing reductive compounds via ATF4-dependent activation of VEGF transcription.	Sulfhydryl Compounds	112-117	activating transcription factor 4	Homo sapiens	153-157
15002033-8	2004	These findings suggest that the redox status may be a determinant of Bax-mediated cell death and that manipulation of intracellular thiols may sensitize cells to apoptosis by facilitating Bax insertion into mitochondrial membranes.	Sulfhydryl Compounds	132-138	BCL2 associated X, apoptosis regulator	Homo sapiens	188-191
14747474-7	2004	Furthermore, thiol reductant thioredoxin blocked the caspase-9 activation step and the cell death induction.	Sulfhydryl Compounds	13-18	caspase 9	Homo sapiens	53-62
15025922-0	2004	Thiol oxidation enforces phosphatidylserine externalization in apoptosis-sensitive and -resistant cells through a deltapsim/cytochrome C release-dependent mechanism.	Sulfhydryl Compounds	0-5	cytochrome c, somatic	Homo sapiens	124-136
15025922-4	2004	Oxidation of sulfhydryls in both cell types with N-ethylmaleimide resulted in rapid disruption of the mitochondrial membrane potential, release of cytochrome c from the mitochondria to the cytoplasm, and externalization of PS by a mechanism that was not inhibited by the pan caspase inhibiter zVAD-fmk.	Sulfhydryl Compounds	13-24	cytochrome c, somatic	Homo sapiens	147-159
14998722-0	2004	Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression.	Sulfhydryl Compounds	0-5	heme oxygenase 1	Homo sapiens	100-116
15049816-0	2004	Oxidative stress triggers thiol oxidation in the glyceraldehyde-3-phosphate dehydrogenase of Staphylococcus aureus.	Sulfhydryl Compounds	26-31	AT695_RS09095	Staphylococcus aureus	49-89
14998722-0	2004	Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression.	Sulfhydryl Compounds	22-27	heme oxygenase 1	Homo sapiens	100-116
14998722-10	2004	These results suggest that thiol antioxidant and reducing agents attenuate the expression of HO-1 induced by 15d-PGJ(2), and that the cellular thiol-disulfide redox status may be linked to HO-1 activation.	Sulfhydryl Compounds	27-32	heme oxygenase 1	Homo sapiens	93-97
14748687-11	2004	A20 cleaved ubiquitin monomers from branched polyubiquitin chains linked through Lys48 or Lys63 and bound covalently to a thiol-group-reactive, ubiquitin-derived probe.	Sulfhydryl Compounds	122-127	TNF alpha induced protein 3	Homo sapiens	0-3
14998722-10	2004	These results suggest that thiol antioxidant and reducing agents attenuate the expression of HO-1 induced by 15d-PGJ(2), and that the cellular thiol-disulfide redox status may be linked to HO-1 activation.	Sulfhydryl Compounds	27-32	heme oxygenase 1	Homo sapiens	189-193
14998722-10	2004	These results suggest that thiol antioxidant and reducing agents attenuate the expression of HO-1 induced by 15d-PGJ(2), and that the cellular thiol-disulfide redox status may be linked to HO-1 activation.	Sulfhydryl Compounds	143-148	heme oxygenase 1	Homo sapiens	189-193
15104111-6	2004	The inactivation of PON1, either purified or HDL-bound, by ascorbate/Cu2+ was prevented by catalase or thiols, but not general hydroxyl radical scavengers, suggesting the involvement of Cu(2+)-catalyzed oxidation in PON1 inactivation.	Sulfhydryl Compounds	103-109	paraoxonase 1	Homo sapiens	20-24
14592831-0	2004	Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry.	Sulfhydryl Compounds	0-5	C-X-C motif chemokine receptor 4	Homo sapiens	47-52
14979728-2	2004	NO has been shown to promote guanine nucleotide exchange on the critical cellular signaling protein p21Ras (Ras) by S-nitrosylation of a redox-active thiol group (Cys(118)).	Sulfhydryl Compounds	150-155	HRas proto-oncogene, GTPase	Homo sapiens	100-106
14989266-6	2004	Interleukin-1, one of the key players in inflammatory response, stimulates the production of ROS itself, but its signaling cascade can also be influenced by ROS and by thiol modifying agents.	Sulfhydryl Compounds	168-173	interleukin 1 alpha	Homo sapiens	0-13
14989266-8	2004	We here summarize what is known about the effects of thiol modifying agents, selenium and glutathione peroxidases, on the assembly of the IL-1 receptor signaling complex as an early event, on the activation of NF-kappa B as an intermediate event, and on the expression of cell adhesion molecules as a late event in IL-1 signaling.	Sulfhydryl Compounds	53-58	nuclear factor kappa B subunit 1	Homo sapiens	210-220
14616092-4	2004	We hypothesized that electrophilic lipids are capable of activating ARE through thiol modification of Keap1 and we have tested this concept in an intact cell system using induction of glutathione synthesis by the cyclopentenone prostaglandin, 15-deoxy-Delta12,14-prostaglandin J2.	Sulfhydryl Compounds	80-85	kelch like ECH associated protein 1	Homo sapiens	102-107
14616092-5	2004	On exposure to 15-deoxy-Delta12,14-prostaglandin J2, the dissociation of Nrf2 from Keap1 occurred and this was dependent on the modification of thiols in Keap1.	Sulfhydryl Compounds	144-150	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
14616092-5	2004	On exposure to 15-deoxy-Delta12,14-prostaglandin J2, the dissociation of Nrf2 from Keap1 occurred and this was dependent on the modification of thiols in Keap1.	Sulfhydryl Compounds	144-150	kelch like ECH associated protein 1	Homo sapiens	83-88
14616092-5	2004	On exposure to 15-deoxy-Delta12,14-prostaglandin J2, the dissociation of Nrf2 from Keap1 occurred and this was dependent on the modification of thiols in Keap1.	Sulfhydryl Compounds	144-150	kelch like ECH associated protein 1	Homo sapiens	154-159
14871477-4	2004	The activity of PDI was irreversibly inhibited with a concurrent loss of two thiols; however, PDI oxidative refolding activity was not completely inhibited.	Sulfhydryl Compounds	77-83	prolyl 4-hydroxylase subunit beta	Homo sapiens	16-19
14592831-0	2004	Thiol/disulfide exchange is a prerequisite for CXCR4-tropic HIV-1 envelope-mediated T-cell fusion during viral entry.	Sulfhydryl Compounds	0-5	endogenous retrovirus group K member 20	Homo sapiens	66-74
14592831-6	2004	We further find that PDI facilitates thiol/disulfide rearrangement in gp120 during conformational change, whereas inhibition of this redox shuffling prevents gp41 from assuming the fusogenic 6-helix bundle conformation.	Sulfhydryl Compounds	37-42	prolyl 4-hydroxylase subunit beta	Homo sapiens	21-24
14592831-6	2004	We further find that PDI facilitates thiol/disulfide rearrangement in gp120 during conformational change, whereas inhibition of this redox shuffling prevents gp41 from assuming the fusogenic 6-helix bundle conformation.	Sulfhydryl Compounds	37-42	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	70-75
14757316-1	2004	Rate constants of 0.0054 and 0.021 M(-1)s(-1) for the reactions of acrylamide with human serum albumin (HSA) and glutathione (GSH), respectively, were determined under physiological conditions by following the loss of their thiol groups in the presence of excess acrylamide.	Sulfhydryl Compounds	224-229	albumin	Homo sapiens	89-102
15004850-2	2004	We have recently described a new laser-induced fluorescence capillary electrophoresis (CE-LIF) method to measure total plasma thiols, in which the baseline separation of cysteinylglycine, homocysteine, cysteine, and glutathione was achieved by adding the organic base N-methyl-D-glucamine to the run buffer.	Sulfhydryl Compounds	126-132	LIF interleukin 6 family cytokine	Homo sapiens	90-93
14967442-5	2004	RESULTS: Manganese superoxide dismutase-overexpressing 2C6 cells maintained higher levels of ascorbate (5.4 +/- 0.5 and 2.6 +/- 0.5 nmol/10(6) cells, respectively) and thiols (14.0 +/- 0.1 and 11.1 +/- 0.2 nmol/10(6) cells) compared to 32D cl 3 parent cells.	Sulfhydryl Compounds	168-174	superoxide dismutase 2	Homo sapiens	9-39
14871400-8	2004	Thiol-replenishing reagents, which can restore modified protein thiols, attenuated 15dPGJ2-induced HSP70 levels.	Sulfhydryl Compounds	0-5	heat shock protein family A (Hsp70) member 4	Homo sapiens	99-104
14871400-8	2004	Thiol-replenishing reagents, which can restore modified protein thiols, attenuated 15dPGJ2-induced HSP70 levels.	Sulfhydryl Compounds	64-70	heat shock protein family A (Hsp70) member 4	Homo sapiens	99-104
14871400-10	2004	15dPGJ2 also activated the stress-responsive transcription factor Nrf2, which requires thiol modification of its cytoplasmic inhibitor protein for transcriptional activity, and induced the Nrf2-dependent stress protein heme oxygenase-1 (HO-1).	Sulfhydryl Compounds	87-92	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
15090958-12	2004	For all patients, there was a positive correlation between albumin and plasma thiol concentrations (r =.983, p &lt;.01) and albumin and antioxidant capacity (r =.885, p =.01).	Sulfhydryl Compounds	78-83	albumin	Homo sapiens	59-66
15090958-13	2004	In the albumin treatment group, there was a strong correlation between thiols and antioxidant capacity (r =.876, p =.01).	Sulfhydryl Compounds	71-77	albumin	Homo sapiens	7-14
15090958-16	2004	CONCLUSIONS: In patients with acute lung injury, albumin administration favorably influences plasma thiol-dependent antioxidant status as well as levels of protein oxidative damage.	Sulfhydryl Compounds	100-105	albumin	Homo sapiens	49-56
14687922-2	2004	Although inhibition by thiol reagents is a general feature of DPP III originating from various species, the function of activity important sulfhydryl groups is still inadequately understood.	Sulfhydryl Compounds	23-28	dipeptidyl peptidase 3	Homo sapiens	62-69
14687922-9	2004	Physiological concentrations of biological thiols and H(2)O(2) inactivated the rat DPP III.	Sulfhydryl Compounds	43-49	dipeptidylpeptidase 3	Rattus norvegicus	83-90
15049834-5	2004	The Thz ring, protecting both the amino and thiol groups in Nin-Cys, completely avoids the formylation and Thz side reactions found during hydrofluoric acid (HF) cleavage when N-pi-benzyloxymethyl histidine groups are present.	Sulfhydryl Compounds	44-49	ninein	Homo sapiens	60-63
14668338-0	2004	Inhibition of apoptosis signal-regulating kinase 1 by nitric oxide through a thiol redox mechanism.	Sulfhydryl Compounds	77-82	mitogen-activated protein kinase kinase kinase 5	Mus musculus	14-50
14668338-5	2004	Furthermore, the NO donor S-nitro-N-acetyl-dl-penicillamine (SNAP) inhibited ASK1 activity in vitro, and this inhibition was reversed by thiol-reducing agents such as dithiothreitol and beta-mercaptoethanol.	Sulfhydryl Compounds	137-142	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	77-81
14975452-9	2004	Thiol-disulfide exchange between tubulin and thioredoxin was detected by Western blot, thereby providing further support for our observations that optimal repair of tubulin disulfides required thioredoxin.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	45-56
14751268-1	2004	The interactions of the unpaired thiol residue (Cys34) of human serum albumin (HSA) with low-molecular-weight thiols and an Au(I)-based antiarthritic drug have been examined using electrospray ionization mass spectrometry.	Sulfhydryl Compounds	33-38	albumin	Homo sapiens	64-77
14751268-1	2004	The interactions of the unpaired thiol residue (Cys34) of human serum albumin (HSA) with low-molecular-weight thiols and an Au(I)-based antiarthritic drug have been examined using electrospray ionization mass spectrometry.	Sulfhydryl Compounds	110-116	albumin	Homo sapiens	64-77
14975452-9	2004	Thiol-disulfide exchange between tubulin and thioredoxin was detected by Western blot, thereby providing further support for our observations that optimal repair of tubulin disulfides required thioredoxin.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	193-204
14687762-9	2004	Addition of the sulfhydryl compounds; glutathione (GSH), N-acetyl-L-cysteine (NAC), L-cysteine or D-penicillamine significantly enhanced the rate of CN- release.	Sulfhydryl Compounds	16-26	X-linked Kx blood group	Homo sapiens	78-81
14741272-1	2004	We have demonstrated that thiol-bearing analogues of alpha-chymotrysin (alpha-CT) substrates such as (S)-(1-benzyl-2-thiolethyl)-carbamic acid, benzyl ester (3) inhibits alpha-CT, a prototypical serine protease, in the presence of Zn(II) ion.	Sulfhydryl Compounds	26-31	coagulation factor II, thrombin	Homo sapiens	195-210
14607844-6	2004	Biochemical characterization of TRP14 suggested that, like Trx1, TRP14 is a disulfide reductase; its active site cysteine is sufficiently nucleophilic with the pK(a) value of 6.1; and its redox potential (-257 mV) is similar to those of other cellular thiol reductants.	Sulfhydryl Compounds	252-257	thioredoxin domain containing 17	Homo sapiens	32-37
14533980-10	2004	Using bovine PLA(2) as an example, we have demonstrated a novel comparative technique, where the conformational stability study of a disulphide-containing protein, with a common denaturant, in both the presence and absence of catalytic amounts of a thiol initiator can be used as a convenient method to estimate selectively and quantitatively the actual contribution of the "native disulphide bond network" towards the global conformational stability of the protein.	Sulfhydryl Compounds	249-254	LOC104974671	Bos taurus	13-19
14676197-4	2004	Oligomerization of CD40 leads to a rapid and significant increase in the disulfide-linked CD40/CD40 homodimer formation, a response that could be prevented using a thiol-alkylating agent.	Sulfhydryl Compounds	164-169	CD40 molecule	Homo sapiens	19-23
14676197-4	2004	Oligomerization of CD40 leads to a rapid and significant increase in the disulfide-linked CD40/CD40 homodimer formation, a response that could be prevented using a thiol-alkylating agent.	Sulfhydryl Compounds	164-169	CD40 molecule	Homo sapiens	90-94
14676197-4	2004	Oligomerization of CD40 leads to a rapid and significant increase in the disulfide-linked CD40/CD40 homodimer formation, a response that could be prevented using a thiol-alkylating agent.	Sulfhydryl Compounds	164-169	CD40 molecule	Homo sapiens	90-94
14744884-2	2004	Because the intracellular thiol redox status of antigen-presenting cells (APCs) reportedly regulates the Th1/Th2 balance through distinctive cytokine production by APCs, this study was conducted to investigate the effect of the intracellular thiol redox status of macrophages (Mps) on corneal allograft survival.	Sulfhydryl Compounds	26-31	negative elongation factor complex member C/D, Th1l	Mus musculus	105-108
14744884-2	2004	Because the intracellular thiol redox status of antigen-presenting cells (APCs) reportedly regulates the Th1/Th2 balance through distinctive cytokine production by APCs, this study was conducted to investigate the effect of the intracellular thiol redox status of macrophages (Mps) on corneal allograft survival.	Sulfhydryl Compounds	26-31	heart and neural crest derivatives expressed 2	Mus musculus	109-112
15009531-0	2004	In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2" position.	Sulfhydryl Compounds	22-27	membrane metalloendopeptidase	Homo sapiens	67-70
15009531-0	2004	In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2" position.	Sulfhydryl Compounds	22-27	angiotensin I converting enzyme	Homo sapiens	72-75
15009531-0	2004	In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2" position.	Sulfhydryl Compounds	22-27	endothelin converting enzyme 1	Homo sapiens	80-83
14607844-6	2004	Biochemical characterization of TRP14 suggested that, like Trx1, TRP14 is a disulfide reductase; its active site cysteine is sufficiently nucleophilic with the pK(a) value of 6.1; and its redox potential (-257 mV) is similar to those of other cellular thiol reductants.	Sulfhydryl Compounds	252-257	thioredoxin	Homo sapiens	59-63
14607844-6	2004	Biochemical characterization of TRP14 suggested that, like Trx1, TRP14 is a disulfide reductase; its active site cysteine is sufficiently nucleophilic with the pK(a) value of 6.1; and its redox potential (-257 mV) is similar to those of other cellular thiol reductants.	Sulfhydryl Compounds	252-257	thioredoxin domain containing 17	Homo sapiens	65-70
14698305-3	2004	Some bacteria, however, including pathogenic mycobacteria, use an alternative low molecular mass thiol compound called mycothiol (MSH) for this purpose.	Sulfhydryl Compounds	97-102	msh homeobox 2	Homo sapiens	130-133
14699087-8	2004	Our results suggest that ERp57 modulates the redox state of ER facing thiols in SERCA 2b in a Ca2+-dependent manner, providing dynamic control of ER Ca2+ homeostasis.	Sulfhydryl Compounds	70-76	protein disulfide isomerase family A member 3	Homo sapiens	25-30
14685283-9	2004	These results suggest that Env is stabilized by Ca(2+) and that receptor binding triggers a cascade of reactions involving Ca(2+) removal, CXXC-thiol exposure, SU-TM disulphide-bond isomerization and SU dissociation, which lead to fusion activation.	Sulfhydryl Compounds	144-149	melanoma antigen	Mus musculus	27-30
14672716-9	2004	Thiol oxidation of DHFR increases susceptibility for tryptic proteolysis.	Sulfhydryl Compounds	0-5	dihydrofolate reductase	Rattus norvegicus	19-23
14735500-4	2004	Design and conceptualization of the corresponding terminal thiols, selenols, and tellurols (M-SH, M-SeH, and M-TeH) offer even more challenging problems to synthetic inorganic chemists.	Sulfhydryl Compounds	59-65	epoxide hydrolase 2	Homo sapiens	100-103
15630200-5	2004	However, this activity can be inhibited by thiol chelators, suggesting that at least one of the two cysteine groups present in VDAC1 are critical for electron transfer.	Sulfhydryl Compounds	43-48	voltage dependent anion channel 1	Homo sapiens	127-132
14654056-7	2004	The use of the thiol-cleavable cross-linker 3,3"-dithiobis(succinimidyl proprionate) facilitated dissociation of alpha-chain-binding proteins by means of dithiothreitol following purification.	Sulfhydryl Compounds	15-20	Fc gamma receptor and transporter	Homo sapiens	113-124
14676285-4	2004	We determined the reactivity of the charged sulfhydryl-modifying reagent, MTSET, with substituted cysteine (Cys) residues along the HCN1 S4 segment.	Sulfhydryl Compounds	44-54	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Homo sapiens	132-136
15061651-5	2004	Ca2+ decreased the content of free thiols in adenine nucleotide translocase (ANT) in mitochondrial membranes with concomitant increase in ROS generation.	Sulfhydryl Compounds	35-41	solute carrier family 25 member 6	Homo sapiens	45-75
15061651-5	2004	Ca2+ decreased the content of free thiols in adenine nucleotide translocase (ANT) in mitochondrial membranes with concomitant increase in ROS generation.	Sulfhydryl Compounds	35-41	solute carrier family 25 member 6	Homo sapiens	77-80
15061651-6	2004	The presence of cyclosporin A, trifluoperazine, or SOD inhibited the Ca(2+)-induced increase of L-012 CHL and decrease in the free thiols of ANT.	Sulfhydryl Compounds	131-137	superoxide dismutase 1	Homo sapiens	51-54
15061651-6	2004	The presence of cyclosporin A, trifluoperazine, or SOD inhibited the Ca(2+)-induced increase of L-012 CHL and decrease in the free thiols of ANT.	Sulfhydryl Compounds	131-137	solute carrier family 25 member 6	Homo sapiens	141-144
15061651-7	2004	These results indicate that Ca2+ increases the generation of ROS which oxidize the free thiol groups in mitochondrial ANT, thereby inducing MPT to release cytochrome c.	Sulfhydryl Compounds	88-93	solute carrier family 25 member 6	Homo sapiens	118-121
15061651-7	2004	These results indicate that Ca2+ increases the generation of ROS which oxidize the free thiol groups in mitochondrial ANT, thereby inducing MPT to release cytochrome c.	Sulfhydryl Compounds	88-93	cytochrome c, somatic	Homo sapiens	155-167
15706060-1	2004	Capsaicin and the principal green tea catechin, (-)-epigallocatechin-3-gallate (EGCg), target tNOX, a tumor (cancer)-specific surface hydroquinone (NADH) oxidase with protein disulfide-thiol interchange activity (ECTO-NOX protein).	Sulfhydryl Compounds	185-190	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	94-98
15499564-4	2004	A single peptide containing both an Abeta(4-10) and T-helper cell epitope, joined by a dipeptide Cys-Acp spacer, was also attached through the thiol function to chloroacetylated poly[Lys(Seri-DL-Alax)] (SAK).	Sulfhydryl Compounds	143-148	polo like kinase 4	Mus musculus	203-206
14729620-4	2004	Then plasmin undergoes autoproteolysis within the inner loop of kringle 5, which can be induced by a free sulfhydryl donor or an alkaline pH.	Sulfhydryl Compounds	106-116	plasminogen	Homo sapiens	5-12
15123225-8	2004	Mean thiol concentration in EBC rose (p&lt;0.05) after treatment with NAC and reached 1.03+/-0.48 microM at 3 h. Although, 25 and 50 mM NAC completely inhibited H(2)O(2)-peroxidase-luminol-dependent chemiluminescence, detectable amounts of H(2)O(2) were generated in NAC solutions.	Sulfhydryl Compounds	5-10	X-linked Kx blood group	Homo sapiens	70-73
16268121-4	2004	Biochemical analysis revealed that alpha-tocopherol suppressed Ca2+-induced ROS generation and oxidation of critical thiol groups of mitochondrial adenine nucleotide translocase (ANT) but not swelling and cytochrome c release.	Sulfhydryl Compounds	117-122	solute carrier family 25 member 6	Homo sapiens	147-177
16268121-4	2004	Biochemical analysis revealed that alpha-tocopherol suppressed Ca2+-induced ROS generation and oxidation of critical thiol groups of mitochondrial adenine nucleotide translocase (ANT) but not swelling and cytochrome c release.	Sulfhydryl Compounds	117-122	solute carrier family 25 member 6	Homo sapiens	179-182
16328790-1	2004	The role of the ferredoxin:thioredoxin system in the reversible light activation of chloroplast enzymes by thiol-disulfide interchange with thioredoxins is now well established.	Sulfhydryl Compounds	107-112	thioredoxin	Homo sapiens	27-38
16328790-1	2004	The role of the ferredoxin:thioredoxin system in the reversible light activation of chloroplast enzymes by thiol-disulfide interchange with thioredoxins is now well established.	Sulfhydryl Compounds	107-112	thioredoxin	Homo sapiens	140-152
14985534-5	2004	Here, cysteine residues were introduced into the anti-CEA diabody at three different locations, to provide specific thiol groups for chemical modification.	Sulfhydryl Compounds	116-121	carcinoembryonic antigen gene family	Mus musculus	54-57
15123225-8	2004	Mean thiol concentration in EBC rose (p&lt;0.05) after treatment with NAC and reached 1.03+/-0.48 microM at 3 h. Although, 25 and 50 mM NAC completely inhibited H(2)O(2)-peroxidase-luminol-dependent chemiluminescence, detectable amounts of H(2)O(2) were generated in NAC solutions.	Sulfhydryl Compounds	5-10	X-linked Kx blood group	Homo sapiens	136-139
15123225-8	2004	Mean thiol concentration in EBC rose (p&lt;0.05) after treatment with NAC and reached 1.03+/-0.48 microM at 3 h. Although, 25 and 50 mM NAC completely inhibited H(2)O(2)-peroxidase-luminol-dependent chemiluminescence, detectable amounts of H(2)O(2) were generated in NAC solutions.	Sulfhydryl Compounds	5-10	X-linked Kx blood group	Homo sapiens	136-139
14644566-1	2003	The thiol N-acetyl-L-cysteine (NAC) is a source of cysteine for the synthesis of the endogenous antioxidant glutathione (GSH) which is depleted by ultraviolet radiation.	Sulfhydryl Compounds	4-9	X-linked Kx blood group	Homo sapiens	31-34
14657342-0	2003	Redox regulation of surface protein thiols: identification of integrin alpha-4 as a molecular target by using redox proteomics.	Sulfhydryl Compounds	36-42	integrin subunit alpha 4	Homo sapiens	62-78
14522974-3	2003	We used cysteine-scanning mutagenesis of the transmembrane segment residues and reaction with the thiol-reactive drug substrate analog of rhodamine, methane-thiosulfonate-rhodamine (MTS-rhodamine), to test whether P-gp could be trapped in an activated state with high levels of ATPase activity.	Sulfhydryl Compounds	98-103	ATP binding cassette subfamily B member 1	Homo sapiens	214-218
14522974-3	2003	We used cysteine-scanning mutagenesis of the transmembrane segment residues and reaction with the thiol-reactive drug substrate analog of rhodamine, methane-thiosulfonate-rhodamine (MTS-rhodamine), to test whether P-gp could be trapped in an activated state with high levels of ATPase activity.	Sulfhydryl Compounds	98-103	dynein axonemal heavy chain 8	Homo sapiens	278-284
12893631-6	2003	Thus the thiol group of GSH is required for inhibition of Mrp2 in the presence of CHEL.	Sulfhydryl Compounds	9-14	ATP binding cassette subfamily C member 2	Rattus norvegicus	58-62
14643928-2	2003	Eighty percent of the sulfhydryl-bound GLUT1 could be eluted with sodium dodecyl sulfate (SDS) indicating that the bound protein was multimeric.	Sulfhydryl Compounds	22-32	solute carrier family 2 member 1	Homo sapiens	39-44
14696916-1	2003	The recombinant human thyroid hormone receptor (TR) was expressed as an in-frame fusion with ten consecutive histidine residues using a bacterial system; then the receptor was immobilized on an Au-electrode with Ni(II)-mediated chemisorption using the histidine tag and thiol-modified nitrilotriacetic acid.	Sulfhydryl Compounds	270-275	telomerase RNA component	Homo sapiens	48-50
12947032-2	2003	We determined whether Gln and KGF alter intra- and extracellular thiol/disulfide redox pools in Caco-2 cells cultured in oxidizing or reducing cell medium and whether such redox variations are a determinant of proliferative responses to these agents.	Sulfhydryl Compounds	65-70	fibroblast growth factor 7	Homo sapiens	30-33
12947032-9	2003	The results indicate that thiol/disulfide redox state in the extracellular milieu is an important determinant of Caco-2 cell proliferation induced by Gln and KGF, that this control is independent of intracellular GSH redox status, and that both Gln and KGF enhance the capability of Caco-2 cells to modulate extremes of extracellular redox.	Sulfhydryl Compounds	26-31	fibroblast growth factor 7	Homo sapiens	158-161
12947032-9	2003	The results indicate that thiol/disulfide redox state in the extracellular milieu is an important determinant of Caco-2 cell proliferation induced by Gln and KGF, that this control is independent of intracellular GSH redox status, and that both Gln and KGF enhance the capability of Caco-2 cells to modulate extremes of extracellular redox.	Sulfhydryl Compounds	26-31	fibroblast growth factor 7	Homo sapiens	253-256
12947032-0	2003	Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells.	Sulfhydryl Compounds	46-51	fibroblast growth factor 7	Homo sapiens	14-17
12962704-8	2003	On the other hand, sodium nitroprusside (SNP) and nitrites inhibit rhodanese activity only in the presence of thiols, which suggests that S-nitrosothiols (RSNO) also have to participate in this reaction in this case.	Sulfhydryl Compounds	110-116	thiosulfate sulfurtransferase	Bos taurus	67-76
14642597-1	2003	A novel class of Cathepsin B inhibitors has been developed with a 1,2,4-thiadiazole heterocycle as the thiol trapping pharmacophore.	Sulfhydryl Compounds	103-108	cathepsin B	Homo sapiens	17-28
14642399-4	2003	Generation of metHb and HbNO is largely dependent on the presence of protein thiol groups.	Sulfhydryl Compounds	77-82	hemoglobin subunit gamma 2	Homo sapiens	14-19
14713291-7	2003	It appears that inhibition of p38 MAPK and p53 phosphorylation by ebselen occurs via a thiol-redox-dependent mechanism.	Sulfhydryl Compounds	87-92	mitogen activated protein kinase 14	Rattus norvegicus	30-33
14713291-7	2003	It appears that inhibition of p38 MAPK and p53 phosphorylation by ebselen occurs via a thiol-redox-dependent mechanism.	Sulfhydryl Compounds	87-92	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	43-46
14575811-5	2003	Moreover, MKK7 activation was markedly reduced by pretreatment of the free radical scavenging thiol antioxidant N-acetylcysteine (NAC).	Sulfhydryl Compounds	94-99	mitogen activated protein kinase kinase 7	Rattus norvegicus	10-14
12972413-1	2003	Heterobifunctional thiol to amine cross-linking agents were used to gain new insights on the dynamics and conformational factors governing the interaction between the cardiac Ca2+ pump (SERCA2a) and phospholamban (PLB).	Sulfhydryl Compounds	19-24	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Canis lupus familiaris	186-193
12972413-1	2003	Heterobifunctional thiol to amine cross-linking agents were used to gain new insights on the dynamics and conformational factors governing the interaction between the cardiac Ca2+ pump (SERCA2a) and phospholamban (PLB).	Sulfhydryl Compounds	19-24	phospholamban	Canis lupus familiaris	214-217
12963719-8	2003	Kinetics of the formation of the irreversibly unfolded species of wild-type beta-lg in 8 M urea at pH 7.0 indicated that, first, an intramolecular thiol-disulfide exchange occurs to produce a mixture of species with non-native disulfide bonds followed by the intermolecular thiol-disulfide exchange producing the oligomers.	Sulfhydryl Compounds	274-279	beta-lactoglobulin	Bos taurus	76-83
12963719-8	2003	Kinetics of the formation of the irreversibly unfolded species of wild-type beta-lg in 8 M urea at pH 7.0 indicated that, first, an intramolecular thiol-disulfide exchange occurs to produce a mixture of species with non-native disulfide bonds followed by the intermolecular thiol-disulfide exchange producing the oligomers.	Sulfhydryl Compounds	147-152	beta-lactoglobulin	Bos taurus	76-83
12963719-9	2003	These results indicate that intramolecular and intermolecular thiol-disulfide exchange reactions cause the low reversibility of wild-type beta-lg especially at neutral pH and that the mutation of Cys-121 improves the reversibility, enabling us to study the folding of beta-lg more exactly under various conditions.	Sulfhydryl Compounds	62-67	beta-lactoglobulin	Bos taurus	138-145
14607909-0	2003	Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.	Sulfhydryl Compounds	14-20	interleukin 4	Homo sapiens	71-75
14628053-3	2003	Here we show that the evolutionarily conserved transcription factor Eyes absent (Eya) belongs to the phosphatase subgroup of the haloacid dehalogenase (HAD) superfamily, and propose a function for it as a non-thiol-based protein tyrosine phosphatase.	Sulfhydryl Compounds	209-214	eyes absent	Drosophila melanogaster	68-79
14628053-3	2003	Here we show that the evolutionarily conserved transcription factor Eyes absent (Eya) belongs to the phosphatase subgroup of the haloacid dehalogenase (HAD) superfamily, and propose a function for it as a non-thiol-based protein tyrosine phosphatase.	Sulfhydryl Compounds	209-214	eyes absent	Drosophila melanogaster	81-84
12954635-0	2003	Highly conserved cysteines of mouse core 2 beta1,6-N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity.	Sulfhydryl Compounds	133-138	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	Mus musculus	43-82
12954635-5	2003	The only non-conserved residue within the beta1,6-N-acetylglucosaminyltransferase family, Cys235, is also a free thiol in the presence of dithiothreitol; however, in the absence of reductant, Cys235 forms an intermolecular disulfide linkage.	Sulfhydryl Compounds	113-118	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	Mus musculus	42-81
14607909-4	2003	To determine the effect of thiols on the production of IFN-gamma and IL-4 by splenocytes, cells were incubated in the presence and the absence of N-acetylcysteine (NAC) and stimulated with alphaCD3 or alphaCD3 and IL-12.	Sulfhydryl Compounds	27-33	interferon gamma	Homo sapiens	55-64
14607909-5	2003	Augmenting intracellular soluble thiol pools ( approximately 2-fold) with 15 mM NAC blocked induction of IFN-gamma and increased production of IL-4 without causing significant changes in intracellular glutathione levels.	Sulfhydryl Compounds	33-38	interferon gamma	Homo sapiens	105-114
14607909-5	2003	Augmenting intracellular soluble thiol pools ( approximately 2-fold) with 15 mM NAC blocked induction of IFN-gamma and increased production of IL-4 without causing significant changes in intracellular glutathione levels.	Sulfhydryl Compounds	33-38	interleukin 4	Homo sapiens	143-147
14607909-9	2003	These studies suggest that increasing intracellular reduced thiol pools decreases IL-12 signaling and IFN-gamma production, while increasing IL-4 production.	Sulfhydryl Compounds	60-65	interferon gamma	Homo sapiens	102-111
14607909-9	2003	These studies suggest that increasing intracellular reduced thiol pools decreases IL-12 signaling and IFN-gamma production, while increasing IL-4 production.	Sulfhydryl Compounds	60-65	interleukin 4	Homo sapiens	141-145
14607909-10	2003	The sum of these effects may contribute to alterations in the balance between Th1 and Th2 responses in lung diseases associated alterations in intracellular thiol pools.	Sulfhydryl Compounds	157-162	negative elongation factor complex member C/D	Homo sapiens	78-81
14575648-4	2003	Among these are metabolic factors (bioactivation by hCYP2C9 or hCYP3A4 to thiol-reactive quinone imines, activation by hUGT2B7 to protein-reactive acyl glucuronides and iso-glucuronides, and 4"-hydroxylation secondary to diclofenac glucuronidation), as well as kinetic factors (Mrp2-mediated concentrative transport of diclofenac metabolites into bile).	Sulfhydryl Compounds	74-79	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	52-59
14615967-10	2003	These simulations revealed that concurrent with NADPH binding to AR, Cys 298 is oriented such that the thiol group will not interact with 4ONE.	Sulfhydryl Compounds	103-108	aldo-keto reductase family 1 member B	Homo sapiens	65-67
14598324-2	2003	We have shown previously that thiol reducing agents, such as dithiothreitol, activate EP 24.15 by mediating the conversion of inactive multimeric forms to active monomers and that this conversion involves the disruption of intermolecular disulfide bonds involving cysteine residues 246, 248, and 253.	Sulfhydryl Compounds	30-35	thimet oligopeptidase 1	Homo sapiens	86-94
14597979-3	2003	Clopidogrel is a potent antithrombotic compound, metabolised by the liver which generates an active metabolite containing a thiol reactive group, responsible for an irreversible interaction with the platelet P2Y(12) ADP receptor.	Sulfhydryl Compounds	124-129	purinergic receptor P2Y12	Rattus norvegicus	208-215
12922157-9	2003	Moreover, insulin and somatostatin were covalently attached to the active linker groups via amine and thiol groups.	Sulfhydryl Compounds	102-107	insulin	Homo sapiens	10-17
14575648-4	2003	Among these are metabolic factors (bioactivation by hCYP2C9 or hCYP3A4 to thiol-reactive quinone imines, activation by hUGT2B7 to protein-reactive acyl glucuronides and iso-glucuronides, and 4"-hydroxylation secondary to diclofenac glucuronidation), as well as kinetic factors (Mrp2-mediated concentrative transport of diclofenac metabolites into bile).	Sulfhydryl Compounds	74-79	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	63-70
12893830-5	2003	Intriguingly, only a trace amount of thiol (10 micro M GSH) was required for reduction of 5-LO activity by GPx-1 or the M-DSP.	Sulfhydryl Compounds	37-42	glutathione peroxidase 1	Bos taurus	107-112
14568990-1	2003	A thiol-reactive membrane-associated protein (TRAP) binds covalently to the cytoplasmic domain of the human insulin receptor (IR) beta-subunit when cells are treated with the homobifunctional cross-linker reagent 1,6-bismaleimidohexane.	Sulfhydryl Compounds	2-7	TRAP	Homo sapiens	46-50
14568990-1	2003	A thiol-reactive membrane-associated protein (TRAP) binds covalently to the cytoplasmic domain of the human insulin receptor (IR) beta-subunit when cells are treated with the homobifunctional cross-linker reagent 1,6-bismaleimidohexane.	Sulfhydryl Compounds	2-7	insulin	Homo sapiens	108-115
14556853-5	2003	Further, the Yap1 C-terminal domain reactivity towards other electrophiles (4-hydroxynonenal, iodoacetamide) and metals (cadmium, selenium) suggests a common mechanism for sensing thiol reactive chemicals, involving thiol chemical modification.	Sulfhydryl Compounds	180-185	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	13-17
12962915-2	2003	Glutaredoxin, a protein disulfide oxido-reductase mediates recovery of complex I by regenerating protein thiols utilizing reducing equivalents of glutathione.	Sulfhydryl Compounds	105-111	glutaredoxin	Mus musculus	0-12
14556853-0	2003	Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling.	Sulfhydryl Compounds	43-48	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	25-29
12963645-10	2003	The thiol antioxidant NAC reduces activation of cPLA2 (assessed by isoform gel-shift and membrane translocation), production of AA in AGE-albumin-exposed neutrophils (H3 release reduced to 104+/-17%, P=0.94 compared with albumin-exposed neutrophils), and the AGE-augmented neutrophil respiratory burst.	Sulfhydryl Compounds	4-9	synuclein alpha	Homo sapiens	22-25
12963645-10	2003	The thiol antioxidant NAC reduces activation of cPLA2 (assessed by isoform gel-shift and membrane translocation), production of AA in AGE-albumin-exposed neutrophils (H3 release reduced to 104+/-17%, P=0.94 compared with albumin-exposed neutrophils), and the AGE-augmented neutrophil respiratory burst.	Sulfhydryl Compounds	4-9	phospholipase A2 group IVA	Homo sapiens	48-53
14556853-5	2003	Further, the Yap1 C-terminal domain reactivity towards other electrophiles (4-hydroxynonenal, iodoacetamide) and metals (cadmium, selenium) suggests a common mechanism for sensing thiol reactive chemicals, involving thiol chemical modification.	Sulfhydryl Compounds	216-221	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	13-17
14556853-6	2003	We propose that Yap1 has two distinct molecular redox centers, one triggered by ROS (hydroperoxides and the superoxide anion) and the other by chemicals with thiol reactivity (electrophiles and divalent heavy metals cations).	Sulfhydryl Compounds	158-163	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	16-20
14517240-0	2003	Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44.	Sulfhydryl Compounds	0-5	endoplasmic reticulum protein 44	Homo sapiens	75-80
14511657-0	2003	Gadd153 restores resistance to radiation-induced apoptosis after thiol depletion.	Sulfhydryl Compounds	65-70	DNA damage inducible transcript 3	Homo sapiens	0-7
14511657-6	2003	The observed protective effect of Gadd153 against radiation-induced apoptosis in thiol depleted lymphoma cells argues for an anti-apoptotic function of Gadd153 after perturbation of the cellular redox state.	Sulfhydryl Compounds	81-86	DNA damage inducible transcript 3	Homo sapiens	34-41
14580323-2	2003	The goal of the current research was to determine the nature of the cysteine residue thiol oxidation that prevents p53 from binding its DNA target and its effect on p53 structure.	Sulfhydryl Compounds	85-90	tumor protein p53	Homo sapiens	115-118
14580323-2	2003	The goal of the current research was to determine the nature of the cysteine residue thiol oxidation that prevents p53 from binding its DNA target and its effect on p53 structure.	Sulfhydryl Compounds	85-90	tumor protein p53	Homo sapiens	165-168
14580323-3	2003	Recombinant p53, purified in the presence of the reducing agent dithiothreitol (DTT), contains five free thiol groups on the surface of the protein.	Sulfhydryl Compounds	105-110	tumor protein p53	Homo sapiens	12-15
14580323-4	2003	In the absence of DTT, p53 contains only four thiol groups, indicating that an average of one surface thiol group is readily susceptible to oxidation.	Sulfhydryl Compounds	46-51	tumor protein p53	Homo sapiens	23-26
14580323-4	2003	In the absence of DTT, p53 contains only four thiol groups, indicating that an average of one surface thiol group is readily susceptible to oxidation.	Sulfhydryl Compounds	102-107	tumor protein p53	Homo sapiens	23-26
14511382-4	2003	The calcium-induced activation and truncation of the MMP-9/CSPG complex was independent of the concentration of the complex, inhibited by the MMP inhibitors EDTA, 1,10-phenanthroline and TIMP-1, but not by general inhibitors of serine, thiol and acid proteinases.	Sulfhydryl Compounds	236-241	matrix metallopeptidase 9	Homo sapiens	53-58
14511382-4	2003	The calcium-induced activation and truncation of the MMP-9/CSPG complex was independent of the concentration of the complex, inhibited by the MMP inhibitors EDTA, 1,10-phenanthroline and TIMP-1, but not by general inhibitors of serine, thiol and acid proteinases.	Sulfhydryl Compounds	236-241	matrix metallopeptidase 9	Homo sapiens	53-56
14529290-7	2003	At pH 6.0, the aromatic thiols increased the folding rate of RNase A by a factor of 10-23 over that observed for glutathione, the standard additive.	Sulfhydryl Compounds	24-30	ribonuclease A family member 1, pancreatic	Homo sapiens	61-68
12909621-4	2003	In this study, we used cysteine-scanning mutagenesis to test whether P-gp could simultaneously interact with the thiol-reactive drug substrate, Tris-(2-maleimidoethyl)amine (TMEA) and a second drug substrate.	Sulfhydryl Compounds	113-118	phosphoglycolate phosphatase	Homo sapiens	69-73
12882976-3	2003	Systematic mutational analysis of all cysteines of Tim10 showed that their underlying molecular defect is impaired folding (demonstrated by circular dichroism, aberrant homo-oligomer formation, and thiol trapping assays).	Sulfhydryl Compounds	198-203	translocase of inner mitochondrial membrane 10	Homo sapiens	51-56
14555475-6	2003	Moreover, treatment of cells with thiol-specific oxidants affects the abundance of Ahp1p-Urm1p conjugates.	Sulfhydryl Compounds	34-39	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	83-88
14517240-5	2003	We conclude that ERp44 is a key element in thiol-mediated retention.	Sulfhydryl Compounds	43-48	endoplasmic reticulum protein 44	Homo sapiens	17-22
14555475-6	2003	Moreover, treatment of cells with thiol-specific oxidants affects the abundance of Ahp1p-Urm1p conjugates.	Sulfhydryl Compounds	34-39	ubiquitin-related modifier URM1	Saccharomyces cerevisiae S288C	89-94
14511233-0	2003	Selective regulation of CD40 expression in murine dendritic cells by thiol antioxidants.	Sulfhydryl Compounds	69-74	CD40 antigen	Mus musculus	24-28
14703797-2	2003	It is possibly that RI may have antioxidant effect by thiol-disulfide exchange reaction.	Sulfhydryl Compounds	54-59	ribonuclease/angiogenin inhibitor 1	Mus musculus	20-22
14703801-9	2003	Incubation of apoferritin with AA (1-10 mM) produced a dose-dependent decrease in tryptophan fluorescence (13-30%, after 5 h), and a partial depletion of protein thiols (29% after 24 h).	Sulfhydryl Compounds	162-168	ferritin heavy chain	Equus caballus	14-25
14554103-0	2003	Mechanism of primary Cd2+-induced rat liver mitochondria dysfunction: discrete modes of Cd2+ action on calcium and thiol-dependent domains.	Sulfhydryl Compounds	115-120	Cd2 molecule	Rattus norvegicus	88-91
12840032-5	2003	Treating the young cells once with 1 mm H2O2 remarkably induced p-Erk1/2 expression; however, it was transient unless repeatedly treated until 72 h. Multiple treatment of the cells with 0.2 mm H2O2 significantly duplicated inactivation of PP1/2A; however, thiol-specific reagents could reverse the PP1/2A activities, suggesting the oxidation of cysteine molecule in PP1/2A by the increased ROS.	Sulfhydryl Compounds	256-261	inorganic pyrophosphatase 1	Homo sapiens	239-245
14554103-7	2003	We have concluded that Cd2+, producing primary mitochondrial dysfunction, acts both as a thiol and Me2+ binding site reagent.	Sulfhydryl Compounds	89-94	Cd2 molecule	Rattus norvegicus	23-26
14599441-5	2003	Dihydropteridine reductase (DHPR), which possessed essential thiol groups at the activity site, plays a crucial role in the maintenance of tetrahydrobiopterin (BH4).	Sulfhydryl Compounds	61-66	quinoid dihydropteridine reductase	Homo sapiens	0-26
14599441-5	2003	Dihydropteridine reductase (DHPR), which possessed essential thiol groups at the activity site, plays a crucial role in the maintenance of tetrahydrobiopterin (BH4).	Sulfhydryl Compounds	61-66	quinoid dihydropteridine reductase	Homo sapiens	28-32
14536032-5	2003	The copper-mediated modification of NF-L was significantly inhibited by thiol antioxidants, Nacetylcysteine, glutathione, and thiourea.	Sulfhydryl Compounds	72-77	neurofilament light chain	Homo sapiens	36-40
14499592-8	2003	alpha-Thrombin denatures by scrambling its native disulfide bonds in the presence of denaturant [urea, guanidine hydrochloride (GdmCl) or guanidine thiocyanate (GdmSCN)] and a thiol initiator.	Sulfhydryl Compounds	176-181	coagulation factor II, thrombin	Homo sapiens	6-14
12963029-2	2003	The properties of TrxR in combination with the functions of Trx position this system at the core of cellular thiol redox control and antioxidant defense.	Sulfhydryl Compounds	109-114	peroxiredoxin 5	Homo sapiens	18-22
12963029-2	2003	The properties of TrxR in combination with the functions of Trx position this system at the core of cellular thiol redox control and antioxidant defense.	Sulfhydryl Compounds	109-114	thioredoxin	Homo sapiens	18-21
12941301-4	2003	Thiol-antioxidant N-acetyl-cysteine (NAC) and reduced glutathione (GSH), when added in vitro to lysates from H(2)O(2)-treated cells, reversed PP1 inhibition.	Sulfhydryl Compounds	0-5	neuropeptide Y receptor Y4	Rattus norvegicus	142-145
12948866-0	2003	Alpha-lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes.	Sulfhydryl Compounds	28-33	insulin receptor	Homo sapiens	52-68
12946157-0	2003	Green protocol for conjugate addition of thiols to alpha,beta-unsaturated ketones using a [bmim]PF6/H2O system.	Sulfhydryl Compounds	41-47	sperm associated antigen 17	Homo sapiens	96-99
12791669-9	2003	We observed the following: adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated; membrane-impermeant thiol blockers inhibited alpha2beta1, but not GPVI mediated, adhesion; direct blockade of PDI revealed that it is involved in adhesion through alpha2beta1 but not GPVI; and purified alpha2beta1, but not recombinant I domain, depended on free thiols for ligation.	Sulfhydryl Compounds	173-178	prolyl 4-hydroxylase subunit beta	Homo sapiens	138-141
12791669-9	2003	We observed the following: adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated; membrane-impermeant thiol blockers inhibited alpha2beta1, but not GPVI mediated, adhesion; direct blockade of PDI revealed that it is involved in adhesion through alpha2beta1 but not GPVI; and purified alpha2beta1, but not recombinant I domain, depended on free thiols for ligation.	Sulfhydryl Compounds	173-178	glycoprotein VI platelet	Homo sapiens	219-223
12791669-9	2003	We observed the following: adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated; membrane-impermeant thiol blockers inhibited alpha2beta1, but not GPVI mediated, adhesion; direct blockade of PDI revealed that it is involved in adhesion through alpha2beta1 but not GPVI; and purified alpha2beta1, but not recombinant I domain, depended on free thiols for ligation.	Sulfhydryl Compounds	173-178	prolyl 4-hydroxylase subunit beta	Homo sapiens	263-266
12791669-9	2003	We observed the following: adhesion to the alpha2beta1-specific peptide was disulfide-exchange dependent and protein disulfide isomerase (PDI) mediated; membrane-impermeant thiol blockers inhibited alpha2beta1, but not GPVI mediated, adhesion; direct blockade of PDI revealed that it is involved in adhesion through alpha2beta1 but not GPVI; and purified alpha2beta1, but not recombinant I domain, depended on free thiols for ligation.	Sulfhydryl Compounds	173-178	glycoprotein VI platelet	Homo sapiens	336-340
12948866-2	2003	In this study, alpha-lipoic acid was demonstrated to stimulate the autophosphorylation of insulin receptor and glucose uptake into 3T3-L1 adipocytes by reducing the thiol reactivity of intracellular proteins.	Sulfhydryl Compounds	165-170	insulin receptor	Homo sapiens	90-106
12948866-4	2003	Alpha-lipoic acid or insulin treatment of adipocytes increased intracellular level of oxidants, decreased thiol reactivity of the insulin receptor beta-subunit, increased tyrosine phosphorylation of the insulin receptor, and enhanced glucose uptake.	Sulfhydryl Compounds	106-111	insulin receptor	Homo sapiens	130-146
12783865-8	2003	The pyrophosphatase activity was potassium-insensitive and inhibited by the pyrophosphate analogs, amynomethylenediphosphonate and imidodiphosphate, by dicyclohexylcarbodiimide, and by the thiol reagent N-ethylmaleimide.	Sulfhydryl Compounds	189-194	AWN88_RS23445	Agrobacterium tumefaciens	4-19
14604470-4	2003	Flow-cytometric quantification of sub-diploid peak, oligonucleosomal cleavage assay (ladder) and depletion of total thiols also corroborated the ability of RP-1 to enhance radiation-induced apoptosis.	Sulfhydryl Compounds	116-122	retinitis pigmentosa 1 (human)	Mus musculus	156-160
12928348-12	2003	After 2 hours of ABP treatment, hepatic thiol levels underwent statistically significant declines of severalfold in Cyp1a2(+/+) and Cyp1a2(-/-) males and in Cyp1a2(-/-) females.	Sulfhydryl Compounds	40-45	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	116-122
12928348-12	2003	After 2 hours of ABP treatment, hepatic thiol levels underwent statistically significant declines of severalfold in Cyp1a2(+/+) and Cyp1a2(-/-) males and in Cyp1a2(-/-) females.	Sulfhydryl Compounds	40-45	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	132-138
12928348-12	2003	After 2 hours of ABP treatment, hepatic thiol levels underwent statistically significant declines of severalfold in Cyp1a2(+/+) and Cyp1a2(-/-) males and in Cyp1a2(-/-) females.	Sulfhydryl Compounds	40-45	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	132-138
12743123-4	2003	Indeed, Ybp1 forms a stress-induced complex with Yap1 in vivo and stimulates the nuclear accumulation of Yap1 in response to H2O2 but not in response to the thiol-oxidizing agent diamide.	Sulfhydryl Compounds	157-162	Ybp1p	Saccharomyces cerevisiae S288C	8-12
14500406-11	2003	In summary, the use of the indole analogues identified NADPH oxidase activity as a novel upstream activity regulating Nrf2/Keap1 signaling of GCLC, provided data supporting the hypothesis that Keap1 is a downstream effector for oxidase activity, and afforded in vivo data to support the hypothesis that Keap1 thiols can act as molecular sensors of reactive oxygen species.	Sulfhydryl Compounds	309-315	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
14500406-11	2003	In summary, the use of the indole analogues identified NADPH oxidase activity as a novel upstream activity regulating Nrf2/Keap1 signaling of GCLC, provided data supporting the hypothesis that Keap1 is a downstream effector for oxidase activity, and afforded in vivo data to support the hypothesis that Keap1 thiols can act as molecular sensors of reactive oxygen species.	Sulfhydryl Compounds	309-315	glutamate-cysteine ligase catalytic subunit	Homo sapiens	142-146
14500406-11	2003	In summary, the use of the indole analogues identified NADPH oxidase activity as a novel upstream activity regulating Nrf2/Keap1 signaling of GCLC, provided data supporting the hypothesis that Keap1 is a downstream effector for oxidase activity, and afforded in vivo data to support the hypothesis that Keap1 thiols can act as molecular sensors of reactive oxygen species.	Sulfhydryl Compounds	309-315	kelch like ECH associated protein 1	Homo sapiens	193-198
14500406-11	2003	In summary, the use of the indole analogues identified NADPH oxidase activity as a novel upstream activity regulating Nrf2/Keap1 signaling of GCLC, provided data supporting the hypothesis that Keap1 is a downstream effector for oxidase activity, and afforded in vivo data to support the hypothesis that Keap1 thiols can act as molecular sensors of reactive oxygen species.	Sulfhydryl Compounds	309-315	kelch like ECH associated protein 1	Homo sapiens	193-198
12777395-7	2003	278, 33049-33055) that the nitrilase-related domain is an essential, obligate intramolecular, thiol-dependent glutamine amidotransferase in the yeast NAD+ synthetase, Qns1.	Sulfhydryl Compounds	94-99	NAD synthetase 1	Homo sapiens	150-165
12777395-7	2003	278, 33049-33055) that the nitrilase-related domain is an essential, obligate intramolecular, thiol-dependent glutamine amidotransferase in the yeast NAD+ synthetase, Qns1.	Sulfhydryl Compounds	94-99	glutamine-dependent NAD(+) synthetase	Saccharomyces cerevisiae S288C	167-171
12749765-7	2003	We found that by treating the transfected cells with the small, water-soluble, thiol-reactive anionic reagent, sodium (2-sulphonatoethyl) methanethiosulphonate, methotrexate transport by several of the cysteine-substituted hRFC mutants was significantly inhibited, including Q40C, G44C, E45C and I48C.	Sulfhydryl Compounds	79-84	solute carrier family 19 member 1	Homo sapiens	223-227
12914934-6	2003	The increase of HIF-1 transcriptional activity was not observed in the case of Cys-800 substitution to Ala, though other protein thiol groups were nitrosated.	Sulfhydryl Compounds	129-134	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
12721298-7	2003	Sx1A inhibition of channel activity was restored by phenylarsine oxide antidote, 2,3-dimercaptopropanol, consistent with thiol interaction of Sx1A.	Sulfhydryl Compounds	121-126	syntaxin 1A	Homo sapiens	0-4
13678524-0	2003	Characterization of the ERp57-Tapasin complex by rapid cellular acidification and thiol modification.	Sulfhydryl Compounds	82-87	protein disulfide isomerase family A member 3	Homo sapiens	24-29
13678524-0	2003	Characterization of the ERp57-Tapasin complex by rapid cellular acidification and thiol modification.	Sulfhydryl Compounds	82-87	TAP binding protein	Homo sapiens	30-37
13678524-3	2003	We have studied ERp57 and the ERp57-tapasin conjugate by rapid acidification of the intracellular environment with trichloroacetic acid (TCA), followed by thiol modification with the alkylating agent 4"-maleimidylstilbene-2,2"-disulfonic acid (AMS).	Sulfhydryl Compounds	155-160	protein disulfide isomerase family A member 3	Homo sapiens	30-35
13678524-3	2003	We have studied ERp57 and the ERp57-tapasin conjugate by rapid acidification of the intracellular environment with trichloroacetic acid (TCA), followed by thiol modification with the alkylating agent 4"-maleimidylstilbene-2,2"-disulfonic acid (AMS).	Sulfhydryl Compounds	155-160	TAP binding protein	Homo sapiens	36-43
12721298-6	2003	Application of a vicinal thiol reagent, phenylarsine oxide, abolished Sx1A action indicating the accessibility of Cys-271,272 thiols.	Sulfhydryl Compounds	126-132	syntaxin 1A	Homo sapiens	70-74
12929176-1	2003	We describe an ultrarapid capillary electrophoresis with laser-induced fluorescence (CE-LIF) method for total plasma thiols measurement.	Sulfhydryl Compounds	117-123	LIF interleukin 6 family cytokine	Homo sapiens	88-91
12929176-2	2003	Reduced thiols by 10% tri-n-butylphosphine (TBP) were derivatized in 10 min at room temperature with 5-iodoacetamidofluorescein (5-IAF) as fluorescent reagent.	Sulfhydryl Compounds	8-14	TATA-box binding protein	Homo sapiens	44-47
12721298-7	2003	Sx1A inhibition of channel activity was restored by phenylarsine oxide antidote, 2,3-dimercaptopropanol, consistent with thiol interaction of Sx1A.	Sulfhydryl Compounds	121-126	syntaxin 1A	Homo sapiens	142-146
12928720-5	2003	Recent evidence suggests that frataxin might detoxify ROS via activation of glutathione peroxidase and elevation of thiols.	Sulfhydryl Compounds	116-122	frataxin	Homo sapiens	30-38
12777388-14	2003	These thiol residues are also modified by biotin-derivatized NEM in the mitochondrial membrane-bound MAO A and MAO B.	Sulfhydryl Compounds	6-11	monoamine oxidase A	Homo sapiens	101-106
12777388-14	2003	These thiol residues are also modified by biotin-derivatized NEM in the mitochondrial membrane-bound MAO A and MAO B.	Sulfhydryl Compounds	6-11	monoamine oxidase B	Homo sapiens	111-116
12883331-5	2003	Thiol reduced reagents, GSH, and dithiothreitol levels, and reversed the MCP-l mRNA expression and protein production in endothelial cells; in addition, thiol oxidized reagent, diamide, and BSO levels, and markedly potentiated homocysteine-mediated up-regulation of MCP-l mRNA expression and protein production in endothelial cells.	Sulfhydryl Compounds	0-5	CD46 molecule pseudogene 1	Homo sapiens	73-78
12883331-5	2003	Thiol reduced reagents, GSH, and dithiothreitol levels, and reversed the MCP-l mRNA expression and protein production in endothelial cells; in addition, thiol oxidized reagent, diamide, and BSO levels, and markedly potentiated homocysteine-mediated up-regulation of MCP-l mRNA expression and protein production in endothelial cells.	Sulfhydryl Compounds	0-5	CD46 molecule pseudogene 1	Homo sapiens	266-271
12902192-5	2003	However, JNK activation in response to Cr(VI) and exogenous H(2)O(2) (1 mM) shared requirements for intracellular thiol oxidation, activation of Src family kinases, and p130(cas) (Cas).	Sulfhydryl Compounds	114-119	mitogen-activated protein kinase 8	Homo sapiens	9-12
12724319-6	2003	These were treated with a thiol-cleavable cross-linking agent, which covalently joined Lys residues in close proximity within or between molecules of apoA-I in the disc.	Sulfhydryl Compounds	26-31	apolipoprotein A1	Homo sapiens	150-156
12850239-8	2003	Moreover, lectin-II-induced activation of caspase-9 and 3-like protease and cleavage of poly(ADP-ribose) polymerase (PARP) were inhibited by pretreatment of cells with thiol antioxidants, GSH and NAC.	Sulfhydryl Compounds	168-173	caspase 9	Homo sapiens	42-51
12850239-8	2003	Moreover, lectin-II-induced activation of caspase-9 and 3-like protease and cleavage of poly(ADP-ribose) polymerase (PARP) were inhibited by pretreatment of cells with thiol antioxidants, GSH and NAC.	Sulfhydryl Compounds	168-173	poly(ADP-ribose) polymerase 1	Homo sapiens	88-115
12850239-8	2003	Moreover, lectin-II-induced activation of caspase-9 and 3-like protease and cleavage of poly(ADP-ribose) polymerase (PARP) were inhibited by pretreatment of cells with thiol antioxidants, GSH and NAC.	Sulfhydryl Compounds	168-173	poly(ADP-ribose) polymerase 1	Homo sapiens	117-121
12860404-1	2003	Application of a thiol-specific probe, monobromobimane, with proteomics and enzyme assays led to the identification of 23 thioredoxin targets in the starchy endosperm of mature wheat seeds (Triticum aestivum cv.	Sulfhydryl Compounds	17-22	thioredoxin H4-2	Triticum aestivum	122-133
12834345-2	2003	Thiol reactive EPR and fluorescent probes were attached to each site as local reporters of mobility and conformational changes upon activation of Galpha(i)GDP by AlF(4)(-), as well as binding to Gbetagamma.	Sulfhydryl Compounds	0-5	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	146-152
12728361-3	2003	The methyl radical, concomitantly released by methyl-coenzyme M (CoM), is rapidly quenched by hydrogen atom transfer from the coenzyme B (CoB) thiol group, yielding methane as the first product of the reaction.	Sulfhydryl Compounds	143-148	metabolism of cobalamin associated B	Homo sapiens	126-136
12788345-4	2003	An amino group at the 6-position and a hydroxyl or thiol group carrying an acidic proton at the 8-position are required to express excellent IFN-inducing activity.	Sulfhydryl Compounds	51-56	interferon alpha 1	Homo sapiens	141-144
14606649-13	2003	NF-kappaB DNA binding could be restored by treating cell lysates with the thiol-reducing agent dithiothreitol (DTT).	Sulfhydryl Compounds	74-79	nuclear factor kappa B subunit 1	Homo sapiens	0-9
12730608-5	2003	First, it was determined if compounds that influenced AsV reduction by purified PNP (i.e., nucleosides, thiols, and PNP inhibitors) would similarly affect reduction of AsV by human erythrocytes.	Sulfhydryl Compounds	104-110	purine nucleoside phosphorylase	Homo sapiens	80-83
14606649-15	2003	CONCLUSIONS: Altogether, the data obtained indicate that GGT activity may impair the redox status of thiols that is critical for NF-kappaB DNA binding and gene transactivation, through the production of prooxidant species allegedly distinct from hydrogen peroxide.	Sulfhydryl Compounds	101-107	gamma-glutamyltransferase 1	Homo sapiens	57-60
14606649-15	2003	CONCLUSIONS: Altogether, the data obtained indicate that GGT activity may impair the redox status of thiols that is critical for NF-kappaB DNA binding and gene transactivation, through the production of prooxidant species allegedly distinct from hydrogen peroxide.	Sulfhydryl Compounds	101-107	nuclear factor kappa B subunit 1	Homo sapiens	129-138
12804604-1	2003	The amino acid sequence of membrane-associated prostaglandin (PG) E synthase-2 (mPGE synthase-2), which has a broad specificity in its thiol requirement for a catalytic activity, has the consensus region from 104Leu to 120Leu found in glutaredoxin and of thioredoxin.	Sulfhydryl Compounds	135-140	glutaredoxin	Homo sapiens	235-247
12707279-1	2003	The sequencing of the genome of Arabidopsis thaliana revealed that this plant contained numerous isoforms of thioredoxin (Trx), a protein involved in thiol-disulfide exchanges.	Sulfhydryl Compounds	150-155	thioredoxin H-type 1	Arabidopsis thaliana	109-120
12707279-1	2003	The sequencing of the genome of Arabidopsis thaliana revealed that this plant contained numerous isoforms of thioredoxin (Trx), a protein involved in thiol-disulfide exchanges.	Sulfhydryl Compounds	150-155	thioredoxin H-type 1	Arabidopsis thaliana	122-125
12804604-1	2003	The amino acid sequence of membrane-associated prostaglandin (PG) E synthase-2 (mPGE synthase-2), which has a broad specificity in its thiol requirement for a catalytic activity, has the consensus region from 104Leu to 120Leu found in glutaredoxin and of thioredoxin.	Sulfhydryl Compounds	135-140	thioredoxin	Homo sapiens	255-266
12805206-3	2003	Using cysteine-scanning mutagenesis and charged thiol-modifying reagents, we identified two amino acids in Kir6.2 that appear to interact directly with ATP: R50 in the N-terminus, and K185 in the C-terminus.	Sulfhydryl Compounds	48-53	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	107-113
12692136-0	2003	Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase.	Sulfhydryl Compounds	71-77	nitric oxide synthase 3	Homo sapiens	107-140
12788228-10	2003	Also, MQ profoundly inhibited the activities of glucose-6-phosphate dehydrogenase (G6PDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), key thiol enzymes involved in glutathione and ATP metabolism, whereas H(2)O(2) produced only a slight decrease in these activities.	Sulfhydryl Compounds	148-153	glucose-6-phosphate dehydrogenase	Bos taurus	48-81
12788228-10	2003	Also, MQ profoundly inhibited the activities of glucose-6-phosphate dehydrogenase (G6PDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), key thiol enzymes involved in glutathione and ATP metabolism, whereas H(2)O(2) produced only a slight decrease in these activities.	Sulfhydryl Compounds	148-153	glucose-6-phosphate dehydrogenase	Bos taurus	83-88
12788228-10	2003	Also, MQ profoundly inhibited the activities of glucose-6-phosphate dehydrogenase (G6PDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), key thiol enzymes involved in glutathione and ATP metabolism, whereas H(2)O(2) produced only a slight decrease in these activities.	Sulfhydryl Compounds	148-153	LOC786101	Bos taurus	94-134
12686548-0	2003	X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines.	Sulfhydryl Compounds	147-153	antioxidant 1 copper chaperone	Homo sapiens	54-58
12686548-3	2003	Here we report the preparation and reconstitution of HAH1 with Cu(I) using a protocol that minimizes the use of thiol reagents believed to be the source of the third ligand.	Sulfhydryl Compounds	112-117	antioxidant 1 copper chaperone	Homo sapiens	53-57
12788103-7	2003	Interestingly, a major fraction of dimeric ARSA-C300F is composed of covalently linked ARSA molecules, through a thiol-cleavable bond that probably involves Cys414 residues from each monomer.	Sulfhydryl Compounds	113-118	arylsulfatase A	Homo sapiens	43-47
12788103-7	2003	Interestingly, a major fraction of dimeric ARSA-C300F is composed of covalently linked ARSA molecules, through a thiol-cleavable bond that probably involves Cys414 residues from each monomer.	Sulfhydryl Compounds	113-118	arylsulfatase A	Homo sapiens	87-91
12732454-5	2003	Both the thiol chelators and the two vitamins were able to increase blood ALAD activity towards normal, however, GSH level responded favorably only to the two thiol chelators.	Sulfhydryl Compounds	9-14	aminolevulinate dehydratase	Rattus norvegicus	74-78
12586629-9	2003	In addition, a labeling experiment with the thiol-modifying reagent biotinylated iodoacetamide (BIAM) in Prx II-/- mice revealed that a variety of RBC proteins were highly oxidized.	Sulfhydryl Compounds	44-49	periaxin	Mus musculus	105-108
12774022-9	2003	In conclusion, these findings suggest that extramitochondrial glutathione depletion alters the thiol-disulfide redox state, leading to inhibition of NF-kappaB transactivation of survival genes and to sustained activation of JNK, both of which contribute to the sensitization to TNF-induced apoptosis.	Sulfhydryl Compounds	95-100	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
12802338-6	2003	We propose that this unusual protein modification both protects the active-site cysteine residue of PTP1B from irreversible oxidation to sulphonic acid and permits redox regulation of the enzyme by promoting its reversible reduction by thiols.	Sulfhydryl Compounds	236-242	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	100-105
12802339-8	2003	In addition, it may facilitate reactivation of PTP1B by biological thiols and signal a unique state of the protein.	Sulfhydryl Compounds	67-73	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	47-52
12745250-1	2003	Oxidoreductases such as glutaredoxin are a major class of enzymes that reversibly catalyze thiol-disulfide exchange reactions.	Sulfhydryl Compounds	91-96	glutaredoxin	Homo sapiens	24-36
12774022-9	2003	In conclusion, these findings suggest that extramitochondrial glutathione depletion alters the thiol-disulfide redox state, leading to inhibition of NF-kappaB transactivation of survival genes and to sustained activation of JNK, both of which contribute to the sensitization to TNF-induced apoptosis.	Sulfhydryl Compounds	95-100	mitogen-activated protein kinase 8	Mus musculus	224-227
12774022-9	2003	In conclusion, these findings suggest that extramitochondrial glutathione depletion alters the thiol-disulfide redox state, leading to inhibition of NF-kappaB transactivation of survival genes and to sustained activation of JNK, both of which contribute to the sensitization to TNF-induced apoptosis.	Sulfhydryl Compounds	95-100	tumor necrosis factor	Mus musculus	278-281
12753316-1	2003	BACKGROUND: Thioredoxin (TRX) is a stress-inducible thiol-containing protein, which has been shown to be an indicator of oxidative stress in a variety of diseases.	Sulfhydryl Compounds	52-57	thioredoxin	Homo sapiens	12-23
12781789-8	2003	Finally, we verified that the inhibitory effect of LGA on tCK was fully prevented by pre-incubation of the homogenates with reduced glutathione (GSH), suggesting that this inhibition is possibly mediated by oxidation of essential thiol groups of the enzyme.	Sulfhydryl Compounds	230-235	glutaminase 2	Homo sapiens	51-54
12796815-4	2003	The results suggest that redox-dependent thiol-disulfide exchange can provide a mechanism for regulation the conformation and activity of hHSF1.	Sulfhydryl Compounds	41-46	heat shock transcription factor 1	Homo sapiens	138-143
12771194-7	2003	Accessibility tests of the introduced thiol groups to extracellular MTS reagents indicate that water-filled crevices penetrate deep into the HERG protein core, reaching the cytoplasmic halves of S1 and S2.	Sulfhydryl Compounds	38-43	potassium voltage-gated channel subfamily H member 2	Homo sapiens	141-145
12743278-5	2003	In contrast, the sulfhydryl-modifying agent N-ethylmaleimide inhibited the formation of disulfide-bonded GP(2b)/GP(3)/GP(4) trimers.	Sulfhydryl Compounds	17-27	integrin subunit alpha 2b	Homo sapiens	105-110
12800095-7	2003	Consistent with the insulin-stimulated oxidative inhibition of thiol-dependent PTPases reported for 3T3-L1 adipocytes and hepatoma cells, treatment of human adipocytes with 100 nmol/L insulin for 5 minutes lowered endogenous PTPase activity to 37% of control (P &lt;.001), which was increased 25% by subsequent treatment with dithiothreitol in vitro.	Sulfhydryl Compounds	63-68	insulin	Homo sapiens	20-27
12800095-7	2003	Consistent with the insulin-stimulated oxidative inhibition of thiol-dependent PTPases reported for 3T3-L1 adipocytes and hepatoma cells, treatment of human adipocytes with 100 nmol/L insulin for 5 minutes lowered endogenous PTPase activity to 37% of control (P &lt;.001), which was increased 25% by subsequent treatment with dithiothreitol in vitro.	Sulfhydryl Compounds	63-68	insulin	Homo sapiens	184-191
12761345-0	2003	Thiol-modifying phenylarsine oxide inhibits guanine nucleotide binding of Rho but not of Rac GTPases.	Sulfhydryl Compounds	0-5	Rac family small GTPase 1	Homo sapiens	89-92
12784209-6	2003	Mass spectrometry data obtained for trypsin-fragmented UV-illuminated alpha-lactalbumin with acrylodan-modified free thiol groups reveal the reduction of the 61-77 and 73-91 disulfide bridges.	Sulfhydryl Compounds	117-122	lactalbumin alpha	Homo sapiens	70-87
12753316-1	2003	BACKGROUND: Thioredoxin (TRX) is a stress-inducible thiol-containing protein, which has been shown to be an indicator of oxidative stress in a variety of diseases.	Sulfhydryl Compounds	52-57	thioredoxin	Homo sapiens	25-28
12560222-0	2003	Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270.	Sulfhydryl Compounds	44-49	purinergic receptor P2Y12	Homo sapiens	26-31
12785846-2	2003	The key building block, a pentasaccharide-Asn analogue containing two thiol residues, was incorporated into CD52 by 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis.	Sulfhydryl Compounds	70-75	CD52 molecule	Homo sapiens	108-112
12862369-4	2003	The thiol fluorescence signal was totally suppressed if the mole ratio of TBP to mBBr was 2.6 or greater.	Sulfhydryl Compounds	4-9	TATA-box binding protein	Homo sapiens	74-77
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Sulfhydryl Compounds	4-9	purinergic receptor P2Y12	Homo sapiens	152-159
12560222-3	2003	The thiol agent p-chloromercuribenzene sulfonic acid (pCMBS) and the active metabolites from antiplatelet drugs, clopidogrel and CS-747, inactivate the P2Y(12) receptor and are predicted to interact with the extracellular cysteine residues on the P2Y(12) receptor.	Sulfhydryl Compounds	4-9	purinergic receptor P2Y12	Homo sapiens	247-254
12560222-4	2003	In this study we identified the reactive cysteine residues on the human P2Y(12) receptor by site-directed mutagenesis using pCMBS as the thiol reagent.	Sulfhydryl Compounds	137-142	purinergic receptor P2Y12	Homo sapiens	72-79
12726917-4	2003	We hypothesized that an amine derivative of alpha-lipoamide (LM), 5-[1,2] dithiolan-3-yl-pentanoic acid (2-dimethylamino-ethyl)-amide (alpha-lipoic acid-plus [LAP]; pKa = 8.0), would concentrate via proton trapping within lysosomes, and that the vicinal thiols of the reduced form of this agent would interact with intralysosomal iron, preventing oxidant-mediated cell damage.	Sulfhydryl Compounds	254-260	acid phosphatase, prostate	Mus musculus	135-157
12726917-5	2003	Using a thiol-reactive fluorochrome, we find that reduced LAP does accumulate within the lysosomes of cultured J774 cells.	Sulfhydryl Compounds	8-13	acid phosphatase, prostate	Mus musculus	58-61
12560222-10	2003	These results indicate that, unlike the P2Y(1) receptor, which has 2 essential disulfide bridges linking its extracellular domains, the P2Y(12) receptor has 2 free cysteines in its extracellular domains (Cys17 and Cys270), both of which are targets of thiol reagents.	Sulfhydryl Compounds	252-257	purinergic receptor P2Y12	Homo sapiens	136-143
12731880-1	2003	Protein disulfide isomerase (PDI) utilizes the active site sequence Cys-Gly-His-Cys (CGHC; E degrees " = -180 mV) to effect thiol-disulfide interchange during oxidative protein folding.	Sulfhydryl Compounds	124-129	protein-disulfide isomerase	Escherichia coli	0-27
12729581-3	2003	The antioxidant glutathione (GSH) and redox-sensitive proteins, thioredoxin and glutathione S-transferase, thus regulate cell death pathways by modulating the redox state of specific thiol residues of target proteins including stress kinases, transcription factors, and caspases.	Sulfhydryl Compounds	183-188	thioredoxin	Homo sapiens	64-75
12729581-3	2003	The antioxidant glutathione (GSH) and redox-sensitive proteins, thioredoxin and glutathione S-transferase, thus regulate cell death pathways by modulating the redox state of specific thiol residues of target proteins including stress kinases, transcription factors, and caspases.	Sulfhydryl Compounds	183-188	glutathione S-transferase kappa 1	Homo sapiens	80-105
12731880-1	2003	Protein disulfide isomerase (PDI) utilizes the active site sequence Cys-Gly-His-Cys (CGHC; E degrees " = -180 mV) to effect thiol-disulfide interchange during oxidative protein folding.	Sulfhydryl Compounds	124-129	protein-disulfide isomerase	Escherichia coli	29-32
12755592-13	2003	Moreover, MCI could be activated by a prior reaction with thiols.	Sulfhydryl Compounds	58-64	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	10-13
12723961-0	2003	Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.	Sulfhydryl Compounds	39-44	folate hydrolase 1	Rattus norvegicus	65-94
12723961-0	2003	Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.	Sulfhydryl Compounds	39-44	folate hydrolase 1	Rattus norvegicus	126-132
12723961-2	2003	The inhibitory potency of these thiol-based compounds against GCP II was found to be dependent on the number of methylene units between the thiol group and pentanedioic acid.	Sulfhydryl Compounds	32-37	folate hydrolase 1	Rattus norvegicus	62-68
12723961-2	2003	The inhibitory potency of these thiol-based compounds against GCP II was found to be dependent on the number of methylene units between the thiol group and pentanedioic acid.	Sulfhydryl Compounds	140-145	folate hydrolase 1	Rattus norvegicus	62-68
12723961-3	2003	A comparison of the SAR of the thiol-based inhibitors to that of the phosphonate-based inhibitors provides insight into the role of each of the two zinc-binding groups in GCP II inhibition.	Sulfhydryl Compounds	31-36	folate hydrolase 1	Rattus norvegicus	171-177
12706574-2	2003	A synthetic hapten of the pesticide conjugated with bovine serum albumin (BSA) was covalently immobilised on the gold-coated side of the cantilever by using thiol self assembled monolayers.	Sulfhydryl Compounds	157-162	albumin	Homo sapiens	59-72
12755592-9	2003	Reaction of MCI with thiol nucleophiles gave products consistent with the formation of a reactive thioacyl chloride intermediate able to react with other nucleophiles present in the reaction medium.	Sulfhydryl Compounds	21-26	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	12-15
12755592-12	2003	Although both MCI and MI can react with thiol nucleophiles, only MCI is capable of significantly reacting with amino nucleophiles of the Lys or His type.	Sulfhydryl Compounds	40-45	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	14-17
12704118-6	2003	Treating mice with diethyl maleate to deplete tissue thiols significantly impaired IFN-gamma production by NK cells, conventional T cells, and CD1d-restricted NK T cells in response to E. coli challenge.	Sulfhydryl Compounds	53-59	interferon gamma	Mus musculus	83-92
12706370-11	2003	The thiol dipeptide cysteinyl-glycine, i.e. the GSH catabolite generated by GGT activity, showed a higher reactivity against cisplatin in vitro than GSH, as was shown by the more rapid oxidation of its -SH groups.	Sulfhydryl Compounds	4-9	inactive glutathione hydrolase 2	Homo sapiens	76-79
12742531-3	2003	However, at present, the status of glutathione (GSH) and thioredoxin (Trx) system, two major thiol redox systems in animal cells during aging and its modulation by CR has not fully been explored.	Sulfhydryl Compounds	93-98	thioredoxin 1	Rattus norvegicus	57-68
12742531-3	2003	However, at present, the status of glutathione (GSH) and thioredoxin (Trx) system, two major thiol redox systems in animal cells during aging and its modulation by CR has not fully been explored.	Sulfhydryl Compounds	93-98	thioredoxin 1	Rattus norvegicus	70-73
12704118-6	2003	Treating mice with diethyl maleate to deplete tissue thiols significantly impaired IFN-gamma production by NK cells, conventional T cells, and CD1d-restricted NK T cells in response to E. coli challenge.	Sulfhydryl Compounds	53-59	CD1d1 antigen	Mus musculus	143-147
12704118-9	2003	The residual IFN-gamma response by NK T cells may explain previous reports of hepatic gene expression following gram-negative bacterial challenge in thiol-depleted mice.	Sulfhydryl Compounds	149-154	interferon gamma	Mus musculus	13-22
12725841-2	2003	Polyacrylic acid was modified with thiol to varying degrees so as to force the polymer to form different loop sizes upon adsorption on the gold SPR sensor surface.	Sulfhydryl Compounds	35-40	sepiapterin reductase	Homo sapiens	144-147
14577152-3	2003	The Na-pump activation as well as the increase in the number of DTNB-reactive thiol groups was abolished after the detergent treatment (0.025% sodium dodecylsulphate); however, the detergent by itself exerted similar influence on Na-pump activity and thiol group content in microsomes.	Sulfhydryl Compounds	78-83	dystrobrevin, beta	Rattus norvegicus	64-68
14577152-3	2003	The Na-pump activation as well as the increase in the number of DTNB-reactive thiol groups was abolished after the detergent treatment (0.025% sodium dodecylsulphate); however, the detergent by itself exerted similar influence on Na-pump activity and thiol group content in microsomes.	Sulfhydryl Compounds	251-256	dystrobrevin, beta	Rattus norvegicus	64-68
14577157-1	2003	The interaction of the molecular chaperonin GroEL with fluorescein-labeled lysozyme in the presence of high concentrations of thiol reagent--dithiothreitol (DTT) has been studied.	Sulfhydryl Compounds	126-131	heat shock protein family D (Hsp60) member 1	Homo sapiens	44-49
12680784-7	2003	Thus, we conclude that an electrophilic quinone oxidation product that reacts with intracellular nucleophiles including protein thiol or GSH plays a major role in the GSTP1 gene expression.	Sulfhydryl Compounds	128-133	glutathione S-transferase pi 1	Homo sapiens	167-172
12705835-10	2003	Subsequent beta-elimination at the C-4 and C-5 positions releases homocysteine as a free thiol.	Sulfhydryl Compounds	89-94	complement C5	Homo sapiens	43-46
12556467-2	2003	Glutaredoxin (GRx, thioltransferase) is implicated in cellular redox regulation, and it is known for specific and efficient catalysis of reduction of protein-S-S-glutathione-mixed disulfides (protein-SSG) because of its remarkably low thiol pK(a) ( approximately 3.5) and its ability to stabilize a catalytic S-glutathionyl intermediate (GRx-SSG).	Sulfhydryl Compounds	19-24	glutaredoxin	Homo sapiens	0-12
12556467-2	2003	Glutaredoxin (GRx, thioltransferase) is implicated in cellular redox regulation, and it is known for specific and efficient catalysis of reduction of protein-S-S-glutathione-mixed disulfides (protein-SSG) because of its remarkably low thiol pK(a) ( approximately 3.5) and its ability to stabilize a catalytic S-glutathionyl intermediate (GRx-SSG).	Sulfhydryl Compounds	19-24	glutaredoxin	Homo sapiens	14-17
12556467-2	2003	Glutaredoxin (GRx, thioltransferase) is implicated in cellular redox regulation, and it is known for specific and efficient catalysis of reduction of protein-S-S-glutathione-mixed disulfides (protein-SSG) because of its remarkably low thiol pK(a) ( approximately 3.5) and its ability to stabilize a catalytic S-glutathionyl intermediate (GRx-SSG).	Sulfhydryl Compounds	19-24	glutaredoxin	Homo sapiens	338-341
12689830-0	2003	Quantification of binding of some thiol-reactive clenbuterol analogues to bovine serum albumin by electron paramagnetic resonance spectroscopy.	Sulfhydryl Compounds	34-39	albumin	Homo sapiens	81-94
12689830-1	2003	The only free thiol group of bovine serum albumin (BSA) was coupled in a high yield with some novel thiol-reactive clenbuterol analogues.	Sulfhydryl Compounds	14-19	albumin	Homo sapiens	36-49
12689830-1	2003	The only free thiol group of bovine serum albumin (BSA) was coupled in a high yield with some novel thiol-reactive clenbuterol analogues.	Sulfhydryl Compounds	100-105	albumin	Homo sapiens	36-49
12680767-7	2003	The thiolate-specific alkylating agent N-ethylmaleimide (NEM) as well as the reversible thiol-specific blockers p-hydroxymercuribenzoic acid (PHMB) and mersalyl acid inhibited PrP(Sc) amplification in vitro, indicating that the conformational change from PrP(C) to PrP(Sc) requires a thiol-containing factor.	Sulfhydryl Compounds	4-9	major prion protein	Mesocricetus auratus	176-179
12682008-2	2003	We show that PAI-2 loses its ability to polymerize following reduction of thiol groups, suggesting that an intramolecular disulfide bond is essential for the polymerization.	Sulfhydryl Compounds	74-79	serpin family B member 2	Homo sapiens	13-18
12680767-7	2003	The thiolate-specific alkylating agent N-ethylmaleimide (NEM) as well as the reversible thiol-specific blockers p-hydroxymercuribenzoic acid (PHMB) and mersalyl acid inhibited PrP(Sc) amplification in vitro, indicating that the conformational change from PrP(C) to PrP(Sc) requires a thiol-containing factor.	Sulfhydryl Compounds	4-9	major prion protein	Mesocricetus auratus	255-258
12680767-7	2003	The thiolate-specific alkylating agent N-ethylmaleimide (NEM) as well as the reversible thiol-specific blockers p-hydroxymercuribenzoic acid (PHMB) and mersalyl acid inhibited PrP(Sc) amplification in vitro, indicating that the conformational change from PrP(C) to PrP(Sc) requires a thiol-containing factor.	Sulfhydryl Compounds	4-9	major prion protein	Mesocricetus auratus	255-258
12680767-7	2003	The thiolate-specific alkylating agent N-ethylmaleimide (NEM) as well as the reversible thiol-specific blockers p-hydroxymercuribenzoic acid (PHMB) and mersalyl acid inhibited PrP(Sc) amplification in vitro, indicating that the conformational change from PrP(C) to PrP(Sc) requires a thiol-containing factor.	Sulfhydryl Compounds	88-93	major prion protein	Mesocricetus auratus	176-179
12680767-7	2003	The thiolate-specific alkylating agent N-ethylmaleimide (NEM) as well as the reversible thiol-specific blockers p-hydroxymercuribenzoic acid (PHMB) and mersalyl acid inhibited PrP(Sc) amplification in vitro, indicating that the conformational change from PrP(C) to PrP(Sc) requires a thiol-containing factor.	Sulfhydryl Compounds	88-93	major prion protein	Mesocricetus auratus	255-258
12877907-1	2003	INTRODUCTION: We investigated whether the platelets from obese subjects are sensitive as those from controls to the antiaggregating effects of N-acetyl-L-cysteine (NAC)-an antioxidant thiol that increases availability of endogenous nitric oxide (NO)-and of superoxide dismutase (SOD) and amifostine which act as scavengers of superoxide anion.	Sulfhydryl Compounds	184-189	X-linked Kx blood group	Homo sapiens	164-167
12680767-7	2003	The thiolate-specific alkylating agent N-ethylmaleimide (NEM) as well as the reversible thiol-specific blockers p-hydroxymercuribenzoic acid (PHMB) and mersalyl acid inhibited PrP(Sc) amplification in vitro, indicating that the conformational change from PrP(C) to PrP(Sc) requires a thiol-containing factor.	Sulfhydryl Compounds	88-93	major prion protein	Mesocricetus auratus	255-258
12659857-4	2003	Homocysteine is shown to be the thiol compound with the most potent inhibitory activity on matrix metalloproteinase 9.	Sulfhydryl Compounds	32-37	matrix metallopeptidase 9	Homo sapiens	91-117
12566444-3	2003	We hypothesized that nitrosothiols that promote protein S-nitrosylation would reduce caspase-3 activation and cell survival, whereas nitric oxide donors (such as 1-propamine 3-(2-hydroxy-2-nitroso-1-propylhydrazine (PAPA) NONOate and diethylamine (DEA) NONOate) that do not target thiol residues would not.	Sulfhydryl Compounds	28-33	caspase 3	Homo sapiens	85-94
12566444-3	2003	We hypothesized that nitrosothiols that promote protein S-nitrosylation would reduce caspase-3 activation and cell survival, whereas nitric oxide donors (such as 1-propamine 3-(2-hydroxy-2-nitroso-1-propylhydrazine (PAPA) NONOate and diethylamine (DEA) NONOate) that do not target thiol residues would not.	Sulfhydryl Compounds	28-33	pappalysin 1	Homo sapiens	216-220
12594173-6	2003	Maintenance and restoration of protein thiol homeostasis by glutaredoxin may be important factors in preventing complex I dysfunction.	Sulfhydryl Compounds	39-44	glutaredoxin	Mus musculus	60-72
12751790-6	2003	Recruitment correlates with the presence of thiol groups in IRAK that were available for IAIT-labeling.	Sulfhydryl Compounds	44-49	interleukin 1 receptor associated kinase 1	Homo sapiens	60-64
12668175-8	2003	The results indicate that nine thiol groups in apoB are distributed in different domains of LDL: two are more exposed, two are buried deeply in the lipid matrix of the particle and the rest are located in hydrophobic parts of this extremely complex protein-lipid assembly.	Sulfhydryl Compounds	31-36	apolipoprotein B	Homo sapiens	47-51
12824000-9	2003	Taken together, these data indicated that gliadin specifically enhanced IL-4-induced IgE production by normal human PBMC, probably by the regulation of redox pathways, and that this "pro-allergenic" effect could be counteracted by natural antioxidants: thiols and/or vectorized SOD1.	Sulfhydryl Compounds	253-259	interleukin 4	Homo sapiens	72-76
12641465-3	2003	CuZnSOD is an efficient catalyst of rHCaBP S-nitrosation, and the mechanism of CuZnSOD-catalyzed S-nitrosation involves reduction of the active-site Cu(II) by a number of the five free thiols in rHCaBP, giving rise to thiyl radicals.	Sulfhydryl Compounds	185-191	superoxide dismutase 1	Homo sapiens	0-7
12641465-3	2003	CuZnSOD is an efficient catalyst of rHCaBP S-nitrosation, and the mechanism of CuZnSOD-catalyzed S-nitrosation involves reduction of the active-site Cu(II) by a number of the five free thiols in rHCaBP, giving rise to thiyl radicals.	Sulfhydryl Compounds	185-191	superoxide dismutase 1	Homo sapiens	79-86
12674327-5	2003	We found that thiol depletion causes a decrease in the expression of osteopontin, type X and type II collagen and a significant loss of alkaline phosphatase activity, suggesting that the expression of the hypertrophic phenotype is tightly regulated by redox levels in chondrocytes.	Sulfhydryl Compounds	14-19	secreted phosphoprotein 1	Gallus gallus	69-80
12674327-5	2003	We found that thiol depletion causes a decrease in the expression of osteopontin, type X and type II collagen and a significant loss of alkaline phosphatase activity, suggesting that the expression of the hypertrophic phenotype is tightly regulated by redox levels in chondrocytes.	Sulfhydryl Compounds	14-19	collagen type II alpha 1 chain	Gallus gallus	82-109
12628223-3	2003	Biotinylation of 11D-TX conjugated bovine serum albumin (BSA) was performed through free thiol groups on BSA using 1-biotinamido-4-[4"-(maleimidomethyl) cyclohexanecarboxamido] butane (Biotin-BMCC).	Sulfhydryl Compounds	89-94	albumin	Mus musculus	42-55
12643793-9	2003	HEDS treatment decreased the GSH and protein thiol (PSH) content more in G6PD-deficient cells than in G6PD-containing cells.	Sulfhydryl Compounds	45-50	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	73-77
12627970-3	2003	A model is presented for regulation of this chain via a thiol reduction mechanism, possibly involving a thioredoxin.	Sulfhydryl Compounds	56-61	thioredoxin	Homo sapiens	104-115
12626594-14	2003	Finally, overexpression of MIF inhibited phosphorylation of endogenous c-Jun induced by thiol starvation, indicating that MIF-based suppression of apoptosis is mediated through modulation of c-Jun N-terminal kinase activity.	Sulfhydryl Compounds	88-93	macrophage migration inhibitory factor	Homo sapiens	27-30
12466018-4	2003	In the presence of the thiol scavenger oxidant, azodicarboxylic acid bis[dimethylamide], at concentrations lethal for G6pd delta but not for wild-type ES cells, NADPH and GSH in G6pd delta cells dramatically shift to their oxidized forms.	Sulfhydryl Compounds	23-28	glucose-6-phosphate dehydrogenase	Homo sapiens	118-122
12466018-4	2003	In the presence of the thiol scavenger oxidant, azodicarboxylic acid bis[dimethylamide], at concentrations lethal for G6pd delta but not for wild-type ES cells, NADPH and GSH in G6pd delta cells dramatically shift to their oxidized forms.	Sulfhydryl Compounds	23-28	glucose-6-phosphate dehydrogenase	Homo sapiens	178-182
12626594-14	2003	Finally, overexpression of MIF inhibited phosphorylation of endogenous c-Jun induced by thiol starvation, indicating that MIF-based suppression of apoptosis is mediated through modulation of c-Jun N-terminal kinase activity.	Sulfhydryl Compounds	88-93	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-76
12626594-14	2003	Finally, overexpression of MIF inhibited phosphorylation of endogenous c-Jun induced by thiol starvation, indicating that MIF-based suppression of apoptosis is mediated through modulation of c-Jun N-terminal kinase activity.	Sulfhydryl Compounds	88-93	macrophage migration inhibitory factor	Homo sapiens	122-125
12626594-14	2003	Finally, overexpression of MIF inhibited phosphorylation of endogenous c-Jun induced by thiol starvation, indicating that MIF-based suppression of apoptosis is mediated through modulation of c-Jun N-terminal kinase activity.	Sulfhydryl Compounds	88-93	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	191-196
12603150-1	2003	Tri- and nonaferrocenyl thiol dendrons have been synthesized and used to assemble dendronized gold nanoparticles either by the ligand-substitution method from dodecanethiolate-gold nanoparticles (AB(3) units) or Brust-type direct synthesis from a 1:1 mixture of dodecanethiol and dendronized thiol (AB(9) units).	Sulfhydryl Compounds	167-172	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	0-3
12614618-0	2003	Crystal structure of the plant PPC decarboxylase AtHAL3a complexed with an ene-thiol reaction intermediate.	Sulfhydryl Compounds	79-84	HAL3-like protein A	Arabidopsis thaliana	49-55
12499112-11	2003	The mechanism of hepatic delta-ALA-D inhibition by Hg(2+)-DMPS/DMSA and Cd(2+)-DMPS/DMSA complexes involve the essential thiol groups of the enzyme.	Sulfhydryl Compounds	121-126	aminolevulinate dehydratase	Homo sapiens	25-36
12615076-8	2003	These results strongly suggested that the electrophilic property characterized by the reactivity with intracellular nucleophiles including protein thiol or glutathione (GSH) plays an important role in the induction of GST.	Sulfhydryl Compounds	147-152	hematopoietic prostaglandin D synthase	Rattus norvegicus	218-221
12509428-2	2003	The skeletal muscle Ca(2+) release channel/ryanodine receptor (RyR1) contains approximately 50 thiols per subunit.	Sulfhydryl Compounds	95-101	ryanodine receptor 1	Homo sapiens	63-67
12509428-9	2003	In contrast, S-nitrosoglutathione activates RyR1 by oxidation and S-nitrosylation of thiols other than Cys-3635 (and calmodulin is not involved).	Sulfhydryl Compounds	85-91	ryanodine receptor 1	Homo sapiens	44-48
12618504-2	2003	For example, plasminogen activators cleave plasminogen into plasmin, and plasmin is converted into angiostatin in the presence of sulfhydryl donors.	Sulfhydryl Compounds	130-140	plasminogen	Homo sapiens	13-20
12572672-4	2003	We have shown that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO+ (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA-binding of IRP2, followed by IRP2 degradation, and these changes were associated with a decrease in TfR mRNA levels.	Sulfhydryl Compounds	139-144	iron responsive element binding protein 2	Mus musculus	200-204
12581635-7	2003	We found a similar order of activity for inhibition of growth and Cdc25A activity using several thiol-containing analogs.	Sulfhydryl Compounds	96-101	cell division cycle 25A	Rattus norvegicus	66-72
12643758-5	2003	To correlate the colligative properties of surface-decorated Hb with the mass of the PEG attached and also its vasoactivity, we have developed a new maleimide-based protocol for the site-specific conjugation of PEG to Hb, taking advantage of the unusually high reactivity of Cys-93(beta) of oxy HbA and the high reactivity of the maleimide to protein thiols.	Sulfhydryl Compounds	351-357	PEG	Bos taurus	211-214
12761168-6	2003	The addition of additional residues to the C-terminal tail of HPC-1/syntaxin 1A allowed labeling by thiol-specific reagents.	Sulfhydryl Compounds	100-105	syntaxin 1A	Homo sapiens	62-67
12761168-6	2003	The addition of additional residues to the C-terminal tail of HPC-1/syntaxin 1A allowed labeling by thiol-specific reagents.	Sulfhydryl Compounds	100-105	syntaxin 1A	Homo sapiens	68-79
12606766-0	2003	Human renal organic anion transporter 1-dependent uptake and toxicity of mercuric-thiol conjugates in Madin-Darby canine kidney cells.	Sulfhydryl Compounds	82-87	solute carrier family 22 member 6	Homo sapiens	12-39
12651114-11	2003	Recombinant human pyroglutamyl-peptidase I was active on pGlu-aminomethylcoumarin in the range pH 6-9, with maximal activity being seen at pH 7.0-8.5; it showed an absolute requirement for a thiol-reducing agent.	Sulfhydryl Compounds	191-196	pyroglutamyl-peptidase I	Homo sapiens	18-42
12798306-4	2003	Thiol-deprivation strongly diminished the capacity of IL-2-activated human NK cells to kill porcine endothelial cells.	Sulfhydryl Compounds	0-5	interleukin 2	Homo sapiens	54-58
12573287-3	2003	Because NO-derived species also modify reactive thiols, we postulated that NO would reversibly inhibit PTP1B.	Sulfhydryl Compounds	48-54	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	103-108
12565167-1	2003	ECTO-NOX protein"s are cell surface-associated and growth-related hydroquinone oxidases with both protein disulfide-thiol interchange activity and the capacity to oxidize NAD(P)H. The activities of these ECTO-NOX proteins are not steady state but fluctuate to create a repeating pattern of oscillations.	Sulfhydryl Compounds	116-121	tripartite motif containing 33	Homo sapiens	0-4
12565167-1	2003	ECTO-NOX protein"s are cell surface-associated and growth-related hydroquinone oxidases with both protein disulfide-thiol interchange activity and the capacity to oxidize NAD(P)H. The activities of these ECTO-NOX proteins are not steady state but fluctuate to create a repeating pattern of oscillations.	Sulfhydryl Compounds	116-121	tripartite motif containing 33	Homo sapiens	204-208
12559980-0	2003	Nitroxyl-mediated disruption of thiol proteins: inhibition of the yeast transcription factor Ace1.	Sulfhydryl Compounds	32-37	Cup2p	Saccharomyces cerevisiae S288C	93-97
12573287-6	2003	Analysis of thiol oxidation status using immunoprecipitated PTP1B showed modification consistent with loss of activity.	Sulfhydryl Compounds	12-17	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	60-65
12559980-5	2003	Herein, we have examined the effect of HNO on the thiol-containing, metal-responsive, yeast transcription factor Ace1 under a variety of cellular conditions as a means of delineating the chemistry of HNO interactions with this representative thiol protein.	Sulfhydryl Compounds	50-55	Cup2p	Saccharomyces cerevisiae S288C	113-117
12559980-5	2003	Herein, we have examined the effect of HNO on the thiol-containing, metal-responsive, yeast transcription factor Ace1 under a variety of cellular conditions as a means of delineating the chemistry of HNO interactions with this representative thiol protein.	Sulfhydryl Compounds	242-247	Cup2p	Saccharomyces cerevisiae S288C	113-117
12617394-8	2003	It was concluded that, when beta-Ig and kappa-casein were heated together, beta-Ig formed thiol-exposed monomers, which reacted with each other or with the native kappa-casein depending on the relative concentrations of beta-Ig and kappa-casein.	Sulfhydryl Compounds	90-95	casein kappa	Homo sapiens	40-52
12565802-5	2003	More generally, our experiments support the hypothesis that glutathione can non-specifically become adducted to protein cysteines during oxidative stress, but that the specific, functional reconstitution of protein thiols depends on recognition by an oxidoreductase such as glutaredoxin.	Sulfhydryl Compounds	215-221	glutaredoxin	Homo sapiens	274-286
12617394-8	2003	It was concluded that, when beta-Ig and kappa-casein were heated together, beta-Ig formed thiol-exposed monomers, which reacted with each other or with the native kappa-casein depending on the relative concentrations of beta-Ig and kappa-casein.	Sulfhydryl Compounds	90-95	casein kappa	Homo sapiens	163-175
12617394-8	2003	It was concluded that, when beta-Ig and kappa-casein were heated together, beta-Ig formed thiol-exposed monomers, which reacted with each other or with the native kappa-casein depending on the relative concentrations of beta-Ig and kappa-casein.	Sulfhydryl Compounds	90-95	casein kappa	Homo sapiens	163-175
12558936-0	2003	Induction of c-fos expression by nicotine in human periodontal ligament fibroblasts is related to cellular thiol levels.	Sulfhydryl Compounds	107-112	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	13-18
12558936-13	2003	These results suggest that the nicotine-dependent stress-specific expression of the c-fos gene correlates with cellular thiol levels in human PDLFs.	Sulfhydryl Compounds	120-125	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	84-89
12504900-7	2003	The presence of a free sulfhydryl or hydroxamate group capable of chelating the zinc ion in the active site of the MMPs was generally found to increase the inhibitory activity of the peptides.	Sulfhydryl Compounds	23-33	matrix metallopeptidase 2	Homo sapiens	115-119
12601812-9	2003	In contrast, some members of the thiol specific antioxidant family of proteins, notably antioxidant protein 2 and thioredoxin peroxidases, were expressed at a higher level in the GSTP null mouse livers.	Sulfhydryl Compounds	33-38	thioredoxin 1	Mus musculus	114-125
12560087-6	2003	All 15 free thiol groups found in human HIF-1 alpha are subjected to S-nitrosation.	Sulfhydryl Compounds	12-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	40-51
12504902-5	2003	Incubation of apoferritin with 1-10mM ALA produced dose-dependent decreases in tryptophan fluorescence (11-35% after 5h), and a partial depletion of protein thiols (18% after 24h) despite substantial removal of catalytic iron.	Sulfhydryl Compounds	157-163	ferritin heavy chain 1	Homo sapiens	14-25
12527914-4	2003	Thiol alkylation also inhibited PDGF-BB-induced expression of cyclin A and growth in these cells.	Sulfhydryl Compounds	0-5	cyclin A2	Homo sapiens	62-70
12929381-0	2003	Detection of a metallo-beta-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups.	Sulfhydryl Compounds	86-91	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	39-44
12527914-5	2003	In contrast, thiol alkylation enhanced and sustained the effect of PDGF-BB on the activation of the Jak STAT pathway, and this event was correlated with inhibition of protein tyrosine phosphatase lB activity.	Sulfhydryl Compounds	13-18	signal transducer and activator of transcription 1	Homo sapiens	104-108
12527914-0	2003	Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).	Sulfhydryl Compounds	0-5	signal transducer and activator of transcription 1	Homo sapiens	128-133
12527914-6	2003	Thiol alkylation via inducing the expression of p21(waf1/cip1) in a STAT1- and p53-dependent manner antagonized the downregulation of this cell cycle inhibitory molecule by PDGF-BB.	Sulfhydryl Compounds	0-5	cyclin dependent kinase inhibitor 1A	Homo sapiens	48-61
12527914-0	2003	Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).	Sulfhydryl Compounds	0-5	tumor protein p53	Homo sapiens	138-141
12527914-0	2003	Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).	Sulfhydryl Compounds	0-5	caspase 1	Homo sapiens	173-181
12527914-6	2003	Thiol alkylation via inducing the expression of p21(waf1/cip1) in a STAT1- and p53-dependent manner antagonized the downregulation of this cell cycle inhibitory molecule by PDGF-BB.	Sulfhydryl Compounds	0-5	signal transducer and activator of transcription 1	Homo sapiens	68-73
12527914-0	2003	Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1).	Sulfhydryl Compounds	0-5	cyclin dependent kinase inhibitor 1A	Homo sapiens	186-199
12527914-6	2003	Thiol alkylation via inducing the expression of p21(waf1/cip1) in a STAT1- and p53-dependent manner antagonized the downregulation of this cell cycle inhibitory molecule by PDGF-BB.	Sulfhydryl Compounds	0-5	tumor protein p53	Homo sapiens	79-82
12527914-3	2003	Thiol alkylation inhibited PDGF-BB-induced expression of the Fos and Jun family proteins and AP-1 activity in VSMC.	Sulfhydryl Compounds	0-5	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-64
12527914-7	2003	The inhibition of AP-1 and activation of STATs, particularly STAT1, by thiol alkylation correlated with increased production of active caspase 1 and apoptosis in VSMC.	Sulfhydryl Compounds	71-76	signal transducer and activator of transcription 1	Homo sapiens	41-46
12527914-7	2003	The inhibition of AP-1 and activation of STATs, particularly STAT1, by thiol alkylation correlated with increased production of active caspase 1 and apoptosis in VSMC.	Sulfhydryl Compounds	71-76	signal transducer and activator of transcription 1	Homo sapiens	61-66
12527914-7	2003	The inhibition of AP-1 and activation of STATs, particularly STAT1, by thiol alkylation correlated with increased production of active caspase 1 and apoptosis in VSMC.	Sulfhydryl Compounds	71-76	caspase 1	Homo sapiens	135-144
12570791-3	2003	However, in the early 1990"s, it was demonstrated that experimental radiation nephropathy could be treated with a thiol-containing ACE inhibitor, captopril.	Sulfhydryl Compounds	114-119	angiotensin I converting enzyme	Homo sapiens	131-134
12629973-0	2003	Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking.	Sulfhydryl Compounds	112-122	rhodopsin	Homo sapiens	0-9
14695918-1	2003	Our laboratories have described a novel class of ectoproteins at the cell surface with both NADH or hydroquinone oxidase (NOX) and protein disulfide-thiol interchange activities (ECTO-NOX proteins).	Sulfhydryl Compounds	149-154	tripartite motif containing 33	Homo sapiens	179-183
12517793-0	2003	Paradoxical effects of thiol reagents on Jurkat cells and a new thiol-sensitive mutant form of human mitochondrial superoxide dismutase.	Sulfhydryl Compounds	64-69	superoxide dismutase 1	Homo sapiens	115-135
12517793-8	2003	Because the I58T variant of human SOD2 is thiol-sensitive, we measured SOD in Jurkat cells grown in the presence of thiol agents, observing markedly less SOD activity.	Sulfhydryl Compounds	42-47	superoxide dismutase 2	Homo sapiens	34-38
12517793-8	2003	Because the I58T variant of human SOD2 is thiol-sensitive, we measured SOD in Jurkat cells grown in the presence of thiol agents, observing markedly less SOD activity.	Sulfhydryl Compounds	42-47	superoxide dismutase 1	Homo sapiens	34-37
12517793-8	2003	Because the I58T variant of human SOD2 is thiol-sensitive, we measured SOD in Jurkat cells grown in the presence of thiol agents, observing markedly less SOD activity.	Sulfhydryl Compounds	116-121	superoxide dismutase 2	Homo sapiens	34-38
12517793-8	2003	Because the I58T variant of human SOD2 is thiol-sensitive, we measured SOD in Jurkat cells grown in the presence of thiol agents, observing markedly less SOD activity.	Sulfhydryl Compounds	116-121	superoxide dismutase 1	Homo sapiens	34-37
12517793-8	2003	Because the I58T variant of human SOD2 is thiol-sensitive, we measured SOD in Jurkat cells grown in the presence of thiol agents, observing markedly less SOD activity.	Sulfhydryl Compounds	116-121	superoxide dismutase 1	Homo sapiens	71-74
12517793-9	2003	In cell-free extracts, thiols quickly eliminated the SOD2 activity.	Sulfhydryl Compounds	23-29	superoxide dismutase 2	Homo sapiens	53-57
12952202-5	2003	Further studies using the [14C] CM-DTT thiol reagent indicated that native and deglycosylated BSP incorporated 5.84 and 5.80 mol of 14C/mol of BSP, respectively.	Sulfhydryl Compounds	39-44	integrin binding sialoprotein	Homo sapiens	94-97
15142434-3	2003	Moreover, serum thiols also reflect DNA repair capacity and the possible eventual accumulation of genetic damage, since a key DNA repair enzyme, poly ADP-ribose polymerase (PARP), is thiol/disulfide redox regulated.	Sulfhydryl Compounds	16-22	poly(ADP-ribose) polymerase 1	Homo sapiens	145-171
12605684-1	2003	Antioxidant protein 2 (AOP2) is a member of a family of thiol-specific antioxidants, recently renamed peroxiredoxins, that evolved as part of an elaborate system to counteract and control detrimental effects of oxygen radicals.	Sulfhydryl Compounds	56-61	peroxiredoxin 6	Homo sapiens	0-21
12605684-1	2003	Antioxidant protein 2 (AOP2) is a member of a family of thiol-specific antioxidants, recently renamed peroxiredoxins, that evolved as part of an elaborate system to counteract and control detrimental effects of oxygen radicals.	Sulfhydryl Compounds	56-61	peroxiredoxin 6	Homo sapiens	23-27
15142434-3	2003	Moreover, serum thiols also reflect DNA repair capacity and the possible eventual accumulation of genetic damage, since a key DNA repair enzyme, poly ADP-ribose polymerase (PARP), is thiol/disulfide redox regulated.	Sulfhydryl Compounds	16-22	poly(ADP-ribose) polymerase 1	Homo sapiens	173-177
15142434-3	2003	Moreover, serum thiols also reflect DNA repair capacity and the possible eventual accumulation of genetic damage, since a key DNA repair enzyme, poly ADP-ribose polymerase (PARP), is thiol/disulfide redox regulated.	Sulfhydryl Compounds	16-21	poly(ADP-ribose) polymerase 1	Homo sapiens	145-171
15142434-3	2003	Moreover, serum thiols also reflect DNA repair capacity and the possible eventual accumulation of genetic damage, since a key DNA repair enzyme, poly ADP-ribose polymerase (PARP), is thiol/disulfide redox regulated.	Sulfhydryl Compounds	16-21	poly(ADP-ribose) polymerase 1	Homo sapiens	173-177
12928826-10	2003	Results of this study suggest that the ion pair influenced ERK1 and TNFR1 signaling pathways and affected thiol metabolism, whereas Bcl-2 and Bax were expressed at late stages of the death process.	Sulfhydryl Compounds	106-111	mitogen-activated protein kinase 3	Homo sapiens	59-63
12480557-1	2003	BACKGROUND/AIMS: Thioredoxin (TRX) is a stress-inducible thiol-containing protein.	Sulfhydryl Compounds	57-62	thioredoxin	Homo sapiens	17-28
12480557-1	2003	BACKGROUND/AIMS: Thioredoxin (TRX) is a stress-inducible thiol-containing protein.	Sulfhydryl Compounds	57-62	thioredoxin	Homo sapiens	30-33
15552724-8	2003	Furthermore, CEP suppressed Ca2+-induced thiol modification of adenine nucleotide transloase (ANT).	Sulfhydryl Compounds	41-46	solute carrier family 25 member 6	Homo sapiens	63-92
14769544-5	2003	The induction of ODC, which could be elicited also by (-)-epigallocatechin 3-gallate, a major green tea component, required an early activation of extracellular signal-regulated kinase 1 and 2 (ERK), and both events appeared to be dependent on an alteration of the status of cellular thiol groups.	Sulfhydryl Compounds	284-289	ornithine decarboxylase 1	Homo sapiens	17-20
14769544-5	2003	The induction of ODC, which could be elicited also by (-)-epigallocatechin 3-gallate, a major green tea component, required an early activation of extracellular signal-regulated kinase 1 and 2 (ERK), and both events appeared to be dependent on an alteration of the status of cellular thiol groups.	Sulfhydryl Compounds	284-289	mitogen-activated protein kinase 1	Homo sapiens	147-192
14769544-5	2003	The induction of ODC, which could be elicited also by (-)-epigallocatechin 3-gallate, a major green tea component, required an early activation of extracellular signal-regulated kinase 1 and 2 (ERK), and both events appeared to be dependent on an alteration of the status of cellular thiol groups.	Sulfhydryl Compounds	284-289	mitogen-activated protein kinase 1	Homo sapiens	194-197
15552724-8	2003	Furthermore, CEP suppressed Ca2+-induced thiol modification of adenine nucleotide transloase (ANT).	Sulfhydryl Compounds	41-46	solute carrier family 25 member 6	Homo sapiens	94-97
12470677-1	2002	Here we demonstrate that the thiol-reactive, environmentally sensitive fluorogenic molecules 6-bromoacetyl-2-dimethylaminonaphthalene and 6-acryloyl-2-dimethylaminonaphthalene are substrates for glutathione transferases (GSTs).	Sulfhydryl Compounds	29-34	glutathione S-transferase alpha 1	Homo sapiens	221-225
12804011-1	2003	Antioxidant protein 2 is a unique member of the thiol-specific antioxidant family of proteins known to reduce reactive oxygen species in the presence of thiol-containing electron donors.	Sulfhydryl Compounds	48-53	peroxiredoxin 6	Mus musculus	0-21
12804011-1	2003	Antioxidant protein 2 is a unique member of the thiol-specific antioxidant family of proteins known to reduce reactive oxygen species in the presence of thiol-containing electron donors.	Sulfhydryl Compounds	153-158	peroxiredoxin 6	Mus musculus	0-21
12519694-9	2003	Studies on the susceptibility of CYP1A1 to SeCys conjugates implicated a thiol-reactive intermediate, as evidenced by reduced inhibition levels in the presence of glutathione and N-acetyl cysteine.	Sulfhydryl Compounds	73-78	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	33-39
12452704-1	2002	The photo-and-thiol-driven trans insertion of phenylacetylene into H-Pt bonds of Pt(X)(H)(PPh3)2 (X = SAr, Cl, Br, and I) took place to afford Pt[(Z)-C(H)=CH(Ph)](X)(PPh3)2 in good yields.	Sulfhydryl Compounds	14-19	caveolin 1	Homo sapiens	90-94
12452704-1	2002	The photo-and-thiol-driven trans insertion of phenylacetylene into H-Pt bonds of Pt(X)(H)(PPh3)2 (X = SAr, Cl, Br, and I) took place to afford Pt[(Z)-C(H)=CH(Ph)](X)(PPh3)2 in good yields.	Sulfhydryl Compounds	14-19	caveolin 1	Homo sapiens	166-170
12577238-3	2002	Intestinal-type alkaline phosphatase (IAP) is a major isoenzyme involved in the hydrolysis of amifostine (WR-2721) to its active thiol form WR-I065.	Sulfhydryl Compounds	129-134	alkaline phosphatase, intestinal	Homo sapiens	0-36
12444025-6	2002	We conclude that thiol-specific PEGylation markedly improves the in vivo pharmacokinetic profile of rhalpha1PI and represents a simple, novel strategy to address the therapeutic goal of human leukocyte elastase inhibition.	Sulfhydryl Compounds	17-22	elastase, neutrophil expressed	Homo sapiens	192-210
12485600-5	2002	Using chemical modifications by sulfhydryl reagents with different solubility properties, we conclude that in G6PT1, one thiol group important for activity is facing the cytosol and could be Cys(121) or Cys(362).	Sulfhydryl Compounds	121-126	solute carrier family 37 member 4	Rattus norvegicus	110-115
12485600-7	2002	In the G6PC protein, an accessible thiol group is facing the cytosol and, according to structural predictions, could be Cys(284).	Sulfhydryl Compounds	35-40	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	7-11
12392962-0	2002	Analysis of thiols with tyrosinase-modified carbon paste electrodes based on blocking of substrate recycling.	Sulfhydryl Compounds	12-18	tyrosinase	Homo sapiens	24-34
12392962-1	2002	The enzyme, tyrosinase, was immobilized inside carbon paste electrodes (CPE) for the analysis of thiol-containing compounds such as the reduced form of glutathione (GSH) and L-cysteine.	Sulfhydryl Compounds	97-102	tyrosinase	Homo sapiens	12-22
12553736-3	2002	We named it cathepsin Y due to its localization, acidic pH optimum and the presence of the same set of active site amino acids as in other thiol cathepsins.	Sulfhydryl Compounds	139-144	cathepsin Z	Rattus norvegicus	12-23
12495472-7	2002	Taken together, the present study demonstrates that the costunolide-induced apoptosis depends on intracellular thiols contents, which are modulated by Bcl-2.	Sulfhydryl Compounds	111-117	BCL2 apoptosis regulator	Homo sapiens	151-156
12577238-3	2002	Intestinal-type alkaline phosphatase (IAP) is a major isoenzyme involved in the hydrolysis of amifostine (WR-2721) to its active thiol form WR-I065.	Sulfhydryl Compounds	129-134	alkaline phosphatase, intestinal	Homo sapiens	38-41
12244106-6	2002	A thiol antioxidant, N-acetyl-l-cysteine, or overexpression of an H(2)O(2) scavenger, catalase, inhibited glucose deprivation-induced dissociation of GRX from ASK1.	Sulfhydryl Compounds	2-7	glutaredoxin	Homo sapiens	150-153
12244106-6	2002	A thiol antioxidant, N-acetyl-l-cysteine, or overexpression of an H(2)O(2) scavenger, catalase, inhibited glucose deprivation-induced dissociation of GRX from ASK1.	Sulfhydryl Compounds	2-7	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	159-163
12464172-1	2002	Redox-sensitive transcription factors such as the E. coli OxyR and S. cerevisiae Yap1, are activated by conformational changes that stem from the post-translational modification of reactive protein thiols.	Sulfhydryl Compounds	198-204	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	81-85
12444648-5	2002	The first term of this equation is predominant at pH lower than 3.5, in agreement with the literature for the direct nitrosation of thiols with nitrous acid; the value for the third-order rate constant, k(1) = 7.9 x 10(2) L(2) mol(-2) min(-1), was calculated.	Sulfhydryl Compounds	132-138	CD59 molecule (CD59 blood group)	Homo sapiens	235-241
12372501-0	2002	Synthesis and biological activity of potent heterocyclic thiol-based inhibitors of endothelin-converting enzyme-1.	Sulfhydryl Compounds	57-62	endothelin converting enzyme 1	Rattus norvegicus	83-113
12223492-8	2002	These results, together with those from previous labeling studies with other thiol-reactive compounds, dibromobimane, MTS-verapamil, and MTS-cross-linker substrates, indicate that common residues are involved in the binding of structurally different drug substrates and that P-gp has a common drug-binding site.	Sulfhydryl Compounds	77-82	phosphoglycolate phosphatase	Homo sapiens	275-279
12617985-4	2002	VKOR harbors a thiol red/ox center that is essential for electron transfer leading to vitamin K reduction.	Sulfhydryl Compounds	15-20	vitamin K epoxide reductase complex subunit 1	Homo sapiens	0-4
12419466-6	2002	The lowered total intracellular thiol levels correlated directly to a significant diminished T-cell activation and an elevated synthesis of TNF-alpha in the patient group.	Sulfhydryl Compounds	32-37	tumor necrosis factor	Homo sapiens	140-149
12414706-1	2002	The alpha-helix containing the thiols, SH1 (Cys-707) and SH2 (Cys-697), has been proposed to be one of the structural elements responsible for the transduction of conformational changes in the myosin head (subfragment-1 (S1)).	Sulfhydryl Compounds	31-37	myosin heavy chain 14	Homo sapiens	193-199
12376359-9	2002	These results provide a novel mechanism for differential regulation of CD38 by NO through a cGMP-independent pathway involving S-nitrosylation of thiols.	Sulfhydryl Compounds	146-152	CD38 molecule	Homo sapiens	71-75
12417336-4	2002	In addition, we show that, in contrast to the reversible inhibition of NSM1 by H2O2 or GSSG which involves the formation of disulfide bonds, irreversible inactivation of this enzyme by peroxynitrite generated from SIN1 is likely due to definitive oxidative thiol modification.	Sulfhydryl Compounds	257-262	MAPK associated protein 1	Homo sapiens	214-218
12388830-10	2002	(4) AsV reductase activity of purified PNP, like the cytosolic AsV reductase activity, was inhibited by phosphate (a substrate of PNP alternative to AsV), guanine and hypoxanthine (products of PNP favoring the reverse reaction), mercurial thiol reagents (nonspecific inhibitors of PNP), as well as CI-1000 and BCX-1777 (specific PNP inhibitors).	Sulfhydryl Compounds	239-244	purine nucleoside phosphorylase	Bos taurus	39-42
12431453-11	2002	Maleimidofluorescein labeling of purified GAPDH provided an index of its reduced thiol status.	Sulfhydryl Compounds	81-86	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	42-47
12431453-12	2002	In the absence of DTT, ischemia induced a reduction in the number of free thiols on GAPDH that was reversed on reperfusion.	Sulfhydryl Compounds	74-80	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	84-89
12431453-13	2002	When treated with DTT, the free thiol status of GAPDH could be increased in ischemic but not reperfused samples.	Sulfhydryl Compounds	32-37	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	48-53
12171583-4	2002	Trypanosomes and leishmania possess a unique thiol metabolism in which the ubiquitous glutathione/glutathione reductase system is replaced by trypanothione and trypanothione reductase.	Sulfhydryl Compounds	45-50	glutathione-disulfide reductase	Homo sapiens	98-119
12171583-7	2002	Here we present the current state of knowledge of the thiol metabolism of trypanosomatids, comprising the trypanothione/tryparedoxin, thioredoxin, and ovothiol systems of the parasites.	Sulfhydryl Compounds	54-59	thioredoxin	Homo sapiens	134-145
12463693-4	2002	Heating also decreased free sulphydryl (SH) groups in the MFGM and increased disulphide (SS) groups, suggesting that incorporation of beta-Ig might be due to association with membrane proteins via disulphide bonds.	Sulfhydryl Compounds	40-42	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	58-62
12388830-5	2002	Therefore, we have tested the hypothesis that PNP is responsible for the thiol- and purine nucleoside-dependent reduction of AsV to AsIII by rat liver cytosol.	Sulfhydryl Compounds	73-78	purine nucleoside phosphorylase	Rattus norvegicus	46-49
12390029-7	2002	The myristoyl group restricted the accessibility of one cysteine in GCAP-1 and GCAP-2 observed by measuring the time-dependent thiol reactivity of cysteines.	Sulfhydryl Compounds	127-132	guanylate cyclase activator 1A	Homo sapiens	68-74
12390029-7	2002	The myristoyl group restricted the accessibility of one cysteine in GCAP-1 and GCAP-2 observed by measuring the time-dependent thiol reactivity of cysteines.	Sulfhydryl Compounds	127-132	guanylate cyclase activator 1B	Homo sapiens	79-85
12351392-0	2002	The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974.	Sulfhydryl Compounds	138-143	von Willebrand factor	Homo sapiens	4-25
12403817-3	2002	By probing the accessibility of systematically substituted cysteine residues to thiol blockers (a technique called SCAM), we have identified the pore-lining residues of a gap junction channel composed of Cx32.	Sulfhydryl Compounds	80-85	gap junction protein beta 1 L homeolog	Xenopus laevis	204-208
12185074-0	2002	A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P.	Sulfhydryl Compounds	45-50	selenoprotein P	Homo sapiens	104-119
12185074-8	2002	We next examined the thiol specificity and found that thioredoxin is the preferred electron donor for selenoprotein P.	Sulfhydryl Compounds	21-26	thioredoxin	Homo sapiens	54-65
12185074-8	2002	We next examined the thiol specificity and found that thioredoxin is the preferred electron donor for selenoprotein P.	Sulfhydryl Compounds	21-26	selenoprotein P	Homo sapiens	102-117
12149099-2	2002	We have proposed that both agents cross-link two thiol groups on the adenine nucleotide translocase (ANT) involved in ADP and cyclophilin-D (CyP-D) binding.	Sulfhydryl Compounds	49-54	solute carrier family 25 member 6	Homo sapiens	101-104
12149099-2	2002	We have proposed that both agents cross-link two thiol groups on the adenine nucleotide translocase (ANT) involved in ADP and cyclophilin-D (CyP-D) binding.	Sulfhydryl Compounds	49-54	peptidylprolyl isomerase F	Homo sapiens	126-139
12149099-2	2002	We have proposed that both agents cross-link two thiol groups on the adenine nucleotide translocase (ANT) involved in ADP and cyclophilin-D (CyP-D) binding.	Sulfhydryl Compounds	49-54	peptidylprolyl isomerase F	Homo sapiens	141-146
12171932-7	2002	NEM also abrogated the phosphorylation of p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E induced by PDGF-BB, suggesting that thiol alkylation interferes with the PI3K/Akt pathway at the level of Akt.	Sulfhydryl Compounds	126-131	eukaryotic translation initiation factor 4E	Homo sapiens	84-89
12171932-7	2002	NEM also abrogated the phosphorylation of p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E induced by PDGF-BB, suggesting that thiol alkylation interferes with the PI3K/Akt pathway at the level of Akt.	Sulfhydryl Compounds	126-131	AKT serine/threonine kinase 1	Homo sapiens	168-171
12171932-7	2002	NEM also abrogated the phosphorylation of p70S6K, ribosomal protein S6, 4E-BP1, and eIF4E induced by PDGF-BB, suggesting that thiol alkylation interferes with the PI3K/Akt pathway at the level of Akt.	Sulfhydryl Compounds	126-131	AKT serine/threonine kinase 1	Homo sapiens	196-199
12171932-12	2002	Together, these findings demonstrate for the first time that PP2A mediates thiol alkylation-dependent redox regulation of Akt and cell survival.	Sulfhydryl Compounds	75-80	protein phosphatase 2 phosphatase activator	Homo sapiens	61-65
12171932-12	2002	Together, these findings demonstrate for the first time that PP2A mediates thiol alkylation-dependent redox regulation of Akt and cell survival.	Sulfhydryl Compounds	75-80	AKT serine/threonine kinase 1	Homo sapiens	122-125
12351392-0	2002	The von Willebrand factor-reducing activity of thrombospondin-1 is located in the calcium-binding/C-terminal sequence and requires a free thiol at position 974.	Sulfhydryl Compounds	138-143	thrombospondin 1	Homo sapiens	47-63
12228179-11	2002	Another putative regulatory mechanism involves direct activation of microsomal GST1 by thiol-reactive electrophiles through cysteine 49.	Sulfhydryl Compounds	87-92	glutathione S-transferase mu 1	Homo sapiens	79-83
12161445-5	2002	Likewise, hyperoxidation of Cys(172)/Ser(172) mutant Prx I required not only H(2)O(2), but also a catalysis-supporting thiol (dithiothreitol).	Sulfhydryl Compounds	119-124	peroxiredoxin 1	Homo sapiens	53-58
12416880-4	2002	Thiols in the HPLC effluent compete for complexation of the Cd2+, resulting in a decrease in the fluorescence response.	Sulfhydryl Compounds	0-6	CD2 molecule	Homo sapiens	60-63
12088508-2	2002	In the present study, mutations were introduced at three cysteine residues in canine glutamate/aspartate transporter (GLAST) to investigate the functional significance of thiol groups in response to oxidation.	Sulfhydryl Compounds	171-176	solute carrier family 1 member 3	Canis lupus familiaris	85-116
12088508-2	2002	In the present study, mutations were introduced at three cysteine residues in canine glutamate/aspartate transporter (GLAST) to investigate the functional significance of thiol groups in response to oxidation.	Sulfhydryl Compounds	171-176	solute carrier family 1 member 3	Canis lupus familiaris	118-123
12088508-5	2002	Glutamate-transport activities in COS-7 cells transfected with wild-type and Cys(-) GLAST were inhibited to the same degree when cells were exposed to Hg(2+) and were recovered by the addition of thiol-specific reductant dithiothreitol.	Sulfhydryl Compounds	196-201	solute carrier family 1 member 3	Canis lupus familiaris	84-89
12228189-5	2002	To do that, we took advantage of the fact that heterocyclic thiols can undergo S-methylation catalyzed by the genetically polymorphic drug-metabolizing enzyme thiopurine S-methyltransferase (TPMT).	Sulfhydryl Compounds	60-66	thiopurine S-methyltransferase	Homo sapiens	159-189
12228189-5	2002	To do that, we took advantage of the fact that heterocyclic thiols can undergo S-methylation catalyzed by the genetically polymorphic drug-metabolizing enzyme thiopurine S-methyltransferase (TPMT).	Sulfhydryl Compounds	60-66	thiopurine S-methyltransferase	Homo sapiens	191-195
12355439-0	2002	IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension.	Sulfhydryl Compounds	108-113	interferon gamma	Mus musculus	0-9
12207002-3	2002	Captopril makes few interactions with the protein, but its free thiol group is bound to the zinc, apparently accounting for most of its inhibitory action on LTA4 hydrolase.	Sulfhydryl Compounds	64-69	leukotriene A4 hydrolase	Homo sapiens	157-171
12351714-7	2002	Pretreatment with alpha-lipoic acid, a thiol delivery agent that protects motor neurons from L-BOAA-mediated toxicity prevented the upregulation of thioltransferase and AP1 activation, presumably by maintaining thiol homeostasis.	Sulfhydryl Compounds	39-44	glutaredoxin	Homo sapiens	148-164
12354420-1	2002	Skin sulfhydryl oxidase (SOx) is an enzyme that catalyzes disulfide (S-S) cross-linking through the oxidation of sulfhydryl compounds in the skin.	Sulfhydryl Compounds	113-133	quiescin Q6 sulfhydryl oxidase 1	Mus musculus	0-23
12354420-1	2002	Skin sulfhydryl oxidase (SOx) is an enzyme that catalyzes disulfide (S-S) cross-linking through the oxidation of sulfhydryl compounds in the skin.	Sulfhydryl Compounds	113-133	quiescin Q6 sulfhydryl oxidase 1	Mus musculus	25-28
12351714-7	2002	Pretreatment with alpha-lipoic acid, a thiol delivery agent that protects motor neurons from L-BOAA-mediated toxicity prevented the upregulation of thioltransferase and AP1 activation, presumably by maintaining thiol homeostasis.	Sulfhydryl Compounds	39-44	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	169-172
12420131-5	2002	This region encompasses a number of potential candidate genes including the thiol-specific antioxidant gene Aop2, also known as peroxiredoxin 5 (Prdx5).	Sulfhydryl Compounds	76-81	peroxiredoxin 6	Mus musculus	108-112
12420131-5	2002	This region encompasses a number of potential candidate genes including the thiol-specific antioxidant gene Aop2, also known as peroxiredoxin 5 (Prdx5).	Sulfhydryl Compounds	76-81	peroxiredoxin 5	Mus musculus	128-143
12420131-5	2002	This region encompasses a number of potential candidate genes including the thiol-specific antioxidant gene Aop2, also known as peroxiredoxin 5 (Prdx5).	Sulfhydryl Compounds	76-81	peroxiredoxin 5	Mus musculus	145-150
12119297-12	2002	Interestingly, inhibitor titration studies revealed that only approximately 5% of the total MMP-26 molecules was catalytically active, indicating that the thiol groups of Cys(82) in the active molecules may be dissociated or removed from the active site zinc ions.	Sulfhydryl Compounds	155-160	matrix metallopeptidase 26	Homo sapiens	92-98
12234194-0	2002	Irreversible inactivation of soybean lipoxygenase-1 by hydrophobic thiols.	Sulfhydryl Compounds	67-73	linoleate 9S-lipoxygenase-4	Glycine max	37-49
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	Sulfhydryl Compounds	96-102	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-4	2002	Lipoxygenase catalyzes an oxygenation reaction on each of the aforementioned thiols, as judged by the consumption of O(2).	Sulfhydryl Compounds	77-83	linoleate 9S-lipoxygenase-4	Glycine max	0-12
12234194-11	2002	The results imply that hydrophobic thiols irreversibly inactivate soybean lipoxygenase by a mechanism that involves oxidation at sulfur.	Sulfhydryl Compounds	35-41	linoleate 9S-lipoxygenase-4	Glycine max	74-86
12193649-6	2002	With large excesses of these reagents nearly all thiols of Keap1 react, but sequential reaction with three successive single equivalents (per cysteine residue) of dipyridyl disulfides revealed excellent agreement with pseudo-first order kinetics, rapid successive declines in reaction velocity, and the stoichiometric formation of two equivalents of thiopyridone per reacted cysteine.	Sulfhydryl Compounds	49-55	kelch-like ECH-associated protein 1	Mus musculus	59-64
12213487-6	2002	Indeed, the thiol reagents NEM and PCMBS, both markedly down-modulating HNE nuclear localisation, were able to inhibit HNE-induced increase of TGFbeta1 protein synthesis.	Sulfhydryl Compounds	12-17	transforming growth factor, beta 1	Mus musculus	143-151
12213601-2	2002	Thioredoxin and glutathione (GSH) are two of the major small molecular weight thiol-containing compounds synthesized de novo in mammalian cells that participate in those functions.	Sulfhydryl Compounds	78-83	thioredoxin	Homo sapiens	0-11
12198170-8	2002	Furthermore, the affinity of IFE-5 (but not IFE-3) for m(3)(2,2,7)GTP was reversibly increased when thiol reagents were removed.	Sulfhydryl Compounds	100-105	Eukaryotic translation initiation factor 4E-5	Caenorhabditis elegans	29-34
12213606-0	2002	Thioredoxins and related proteins in photosynthetic organisms: molecular basis for thiol dependent regulation.	Sulfhydryl Compounds	83-88	thioredoxin	Homo sapiens	0-12
12135622-5	2002	Both the thiol chelators were able to increase blood ALAD activity and GSH level towards normal.	Sulfhydryl Compounds	9-14	aminolevulinate dehydratase	Rattus norvegicus	53-57
12204825-6	2002	The finding that HDI exposure increases thioredoxin reductase expression supports previous studies suggesting that HDI alters thiol-redox homeostasis, an important sensor of cellular stress.	Sulfhydryl Compounds	126-131	peroxiredoxin 5	Homo sapiens	40-61
12220264-8	2002	Tracer experiments using (35)SO(4)(2-) in the presence of 0.5 mm L-cysteine or GSH showed that both thiols decreased sulphate uptake, APR activity and the flux of label into cysteine, GSH and protein, but had no effect on the activity of all other enzymes of assimilatory sulphate reduction and serine acetyltransferase.	Sulfhydryl Compounds	100-106	APS reductase 1	Arabidopsis thaliana	134-137
12220264-8	2002	Tracer experiments using (35)SO(4)(2-) in the presence of 0.5 mm L-cysteine or GSH showed that both thiols decreased sulphate uptake, APR activity and the flux of label into cysteine, GSH and protein, but had no effect on the activity of all other enzymes of assimilatory sulphate reduction and serine acetyltransferase.	Sulfhydryl Compounds	100-106	serine acetyltransferase 2;1	Arabidopsis thaliana	295-319
12220264-9	2002	These results are consistent with the hypothesis that thiols regulate the flux through sulphate assimilation at the uptake and the APR step.	Sulfhydryl Compounds	54-60	APS reductase 1	Arabidopsis thaliana	131-134
12220264-0	2002	Flux control of sulphate assimilation in Arabidopsis thaliana: adenosine 5"-phosphosulphate reductase is more susceptible than ATP sulphurylase to negative control by thiols.	Sulfhydryl Compounds	167-173	APS reductase 1	Arabidopsis thaliana	63-101
12021263-8	2002	Reagents that react with sulfhydryl groups, such as cystamine, were potent inhibitors of SR, in a clear reflection that one or more cysteine residues are important for enzyme activity.	Sulfhydryl Compounds	25-35	serine racemase	Homo sapiens	89-91
12193064-0	2002	CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11.	Sulfhydryl Compounds	13-18	endothelin converting enzyme 1	Rattus norvegicus	43-73
12032148-6	2002	When a sulfhydryl enzyme, glyceraldehyde-3-phosphate dehydrogenase, was incubated with acrolein-modified bovine serum albumin in sodium phosphate buffer (pH 7.2) at 37 degrees C, a significant loss of sulfhydryl groups, which was accompanied by the loss of enzyme activity and the formation of high molecular mass protein species (&gt;200 kDa), was observed.	Sulfhydryl Compounds	7-17	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	26-66
12032148-6	2002	When a sulfhydryl enzyme, glyceraldehyde-3-phosphate dehydrogenase, was incubated with acrolein-modified bovine serum albumin in sodium phosphate buffer (pH 7.2) at 37 degrees C, a significant loss of sulfhydryl groups, which was accompanied by the loss of enzyme activity and the formation of high molecular mass protein species (&gt;200 kDa), was observed.	Sulfhydryl Compounds	7-17	albumin	Homo sapiens	112-125
12107049-1	2002	Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein (hsp) genes are the result of oxidation and/or depletion of intracellular thiols.	Sulfhydryl Compounds	358-364	heat shock transcription factor 1	Rattus norvegicus	182-215
12107049-1	2002	Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein (hsp) genes are the result of oxidation and/or depletion of intracellular thiols.	Sulfhydryl Compounds	358-364	heat shock transcription factor 1	Rattus norvegicus	217-221
12107049-1	2002	Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein (hsp) genes are the result of oxidation and/or depletion of intracellular thiols.	Sulfhydryl Compounds	358-364	selenoprotein K	Rattus norvegicus	265-283
12107049-1	2002	Experiments involving chemical induction of the heat shock response in simple biological systems have generated the hypothesis that protein denaturation and consequential binding of heat shock transcription factor 1 (HSF1) to proximal heat shock elements (HSEs) on heat shock protein (hsp) genes are the result of oxidation and/or depletion of intracellular thiols.	Sulfhydryl Compounds	358-364	selenoprotein K	Rattus norvegicus	285-288
12175144-5	2002	The selectivity of the Hg2+ sensor could be improved by coating the gold surface of microcantilever with a self-assembled monolayer of a long-chain thiol compound.	Sulfhydryl Compounds	148-153	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	23-26
12214861-3	2002	Here, the protein disulfide isomerase (PDI) and/or peroxidase-induced oligomerization of unfolded thyroglobulins, which were prepared by treating bovine Tg with heat, urea or thiol/urea, was investigated using SDS-PAGE analyses.	Sulfhydryl Compounds	175-180	prolyl 4-hydroxylase subunit beta	Bos taurus	10-37
12214861-3	2002	Here, the protein disulfide isomerase (PDI) and/or peroxidase-induced oligomerization of unfolded thyroglobulins, which were prepared by treating bovine Tg with heat, urea or thiol/urea, was investigated using SDS-PAGE analyses.	Sulfhydryl Compounds	175-180	prolyl 4-hydroxylase subunit beta	Bos taurus	39-42
12174086-0	2002	Activation of mucin exocytosis and upregulation of MUC genes in polarized human intestinal mucin-secreting cells by the thiol-activated exotoxin listeriolysin O.	Sulfhydryl Compounds	120-125	LOC100508689	Homo sapiens	14-19
12174086-0	2002	Activation of mucin exocytosis and upregulation of MUC genes in polarized human intestinal mucin-secreting cells by the thiol-activated exotoxin listeriolysin O.	Sulfhydryl Compounds	120-125	LOC100508689	Homo sapiens	91-96
12193064-0	2002	CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11.	Sulfhydryl Compounds	13-18	membrane metallo-endopeptidase	Rattus norvegicus	78-105
12193065-1	2002	CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC(50) values of 11 and 5 nM respectively.	Sulfhydryl Compounds	15-20	endothelin converting enzyme 1	Rattus norvegicus	58-88
12193065-1	2002	CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC(50) values of 11 and 5 nM respectively.	Sulfhydryl Compounds	15-20	endothelin converting enzyme 1	Rattus norvegicus	90-95
12193065-1	2002	CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC(50) values of 11 and 5 nM respectively.	Sulfhydryl Compounds	15-20	membrane metallo-endopeptidase	Rattus norvegicus	101-128
12193065-1	2002	CGS 34226 is a thiol-containing, potent dual inhibitor of endothelin converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11 (NEP) with IC(50) values of 11 and 5 nM respectively.	Sulfhydryl Compounds	15-20	membrane metallo-endopeptidase	Rattus norvegicus	130-133
12172882-10	2002	Serum total and non-protein (glutathione) thiols were higher in the LEX and HEX groups following training compared to CON (P &lt; 0.05).	Sulfhydryl Compounds	42-48	hematopoietically expressed homeobox	Homo sapiens	76-79
12119401-7	2002	These data suggest that the intracellular glutathione/glutathione disulfide ratio, an indicator of the redox state of the cell, can regulate Trx functions reversibly through thiol-disulfide exchange reactions.	Sulfhydryl Compounds	174-179	thioredoxin	Homo sapiens	141-144
12089508-5	2002	The redox state of the thiols (disulfide versus dithiol) appeared to be regulated by thioredoxin, which is secreted by CD4(+) T cells.	Sulfhydryl Compounds	23-29	thioredoxin	Homo sapiens	85-96
12089508-5	2002	The redox state of the thiols (disulfide versus dithiol) appeared to be regulated by thioredoxin, which is secreted by CD4(+) T cells.	Sulfhydryl Compounds	23-29	CD4 molecule	Homo sapiens	119-122
12099690-1	2002	Thioredoxin (TRX) is one of major components of thiol reducing systems.	Sulfhydryl Compounds	48-53	thioredoxin	Homo sapiens	0-11
12099690-1	2002	Thioredoxin (TRX) is one of major components of thiol reducing systems.	Sulfhydryl Compounds	48-53	thioredoxin	Homo sapiens	13-16
12432930-4	2002	PGD synthase (PGDS) catalyzes the isomerization of PGH2 to PGD2 in the presence of sulfhydryl compounds.	Sulfhydryl Compounds	83-103	prostaglandin D2 synthase (brain)	Mus musculus	0-12
12432930-4	2002	PGD synthase (PGDS) catalyzes the isomerization of PGH2 to PGD2 in the presence of sulfhydryl compounds.	Sulfhydryl Compounds	83-103	prostaglandin D2 synthase (brain)	Mus musculus	14-18
12432930-4	2002	PGD synthase (PGDS) catalyzes the isomerization of PGH2 to PGD2 in the presence of sulfhydryl compounds.	Sulfhydryl Compounds	83-103	prostaglandin D2 synthase (brain)	Mus musculus	59-63
12139975-9	2002	Such an interpretation is supported by the detection of the loss of thiol groups on GAPDH and the detection of cross-linked materials on protein gels.	Sulfhydryl Compounds	68-73	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	84-89
11978787-7	2002	In vitro, DMBA-3,4-diol was oxidized by AKR1C4 to the highly reactive 7,12-dimethylbenz[a]anthracene-3,4-dione (DMBA-3,4-dione), which was trapped in situ as its mono- and bis-thioether conjugates, which arise from the sequential 1,6- and 1,4-Michael addition of thiol nucleophiles.	Sulfhydryl Compounds	263-268	aldo-keto reductase family 1 member C4	Homo sapiens	40-46
11997384-6	2002	The thiol-reducing antioxidant N-acetylcysteine, and, to a lesser extent, the COX-2 inhibitor celecoxib, attenuated the loss of cell viability induced by cadmium demonstrating that oxidative stress and COX-2 activation contribute to cadmium cytotoxicity.	Sulfhydryl Compounds	4-9	prostaglandin-endoperoxide synthase 2	Mus musculus	202-207
11991955-4	2002	In this study, the thiol-modifying reagent NBD-Cl (7-chloro-4-nitrobenz-2-oxa-1,3-diazole) was used to label peroxide-modified alpha1-antitrypsin and demonstrate that the Cys-232 in vitro oxidation pathway begins with a stable sulfenic acid intermediate and is followed by the formation of sulfinic and cysteic acid in successive steps.	Sulfhydryl Compounds	19-24	serpin family A member 1	Homo sapiens	127-145
12119000-0	2002	Cytochrome P450 3A4-mediated bioactivation of raloxifene: irreversible enzyme inhibition and thiol adduct formation.	Sulfhydryl Compounds	93-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-19
12437106-2	2002	Cathepsin B activity in cysteine-containing buffers was similar at pH 6.0 and pH 7.0, over all thiol concentrations tested.	Sulfhydryl Compounds	95-100	cathepsin B	Homo sapiens	0-11
12065480-4	2002	Matrix-assisted laser desorption ionization mass-spectrometry sequence analysis revealed the 55-kDa protein to be protein disulfide isomerase (PDI), a member of the estrogen receptor complex which carries out thiol-disulfide exchange reactions at infected host cell surfaces.	Sulfhydryl Compounds	209-214	protein disulfide isomerase family A member 2	Homo sapiens	143-146
12091127-0	2002	Methionine synthase polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism.	Sulfhydryl Compounds	122-127	5-methyltetrahydrofolate-homocysteine methyltransferase	Homo sapiens	0-19
12088552-11	2002	The classic mucolytics have free thiol groups to degrade mucin.	Sulfhydryl Compounds	33-38	LOC100508689	Homo sapiens	57-62
12019068-10	2002	Finally, the hLF(1-11)-induced activation of mitochondria was inhibited by NAC, indicating that internal thiols and ROS affect mitochondrial activity.	Sulfhydryl Compounds	105-111	X-linked Kx blood group	Homo sapiens	75-78
11971897-4	2002	Oxidation of thiol groups of cysteines by reactive oxygen, generated during UV irradiation, was the primary event in c-Raf activation, causing the release of zinc ions and, by inference, a change in CRD structure.	Sulfhydryl Compounds	13-18	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	117-122
12806173-4	2002	After expression of the fusion protein and thiol-induced cleavage, the RNase A(1-94) fragment possessed a C-terminal thioester.	Sulfhydryl Compounds	43-48	ribonuclease A family member 1, pancreatic	Homo sapiens	71-78
12044166-2	2002	The fluorophore is attached to a tetrapeptide, Ala-Val-Pro-Cys-NH(2), through a thiol linkage and, upon binding to XIAP, undergoes a solvatochromic shift in fluorescence emission.	Sulfhydryl Compounds	80-85	X-linked inhibitor of apoptosis	Homo sapiens	115-119
12162542-11	2002	We propose that the O2*- generation and Asc* formation in the Hb solution are due to the pseudoperoxidase activity-dependent oxidation of PEA and resultant ROS may damage tissues rich in monoamines, if the Hb-based blood substitutes were circulated without addition of ROS scavengers such as thiols.	Sulfhydryl Compounds	292-298	PYD and CARD domain containing	Homo sapiens	40-44
12010000-8	2002	The thiol reduced a fraction of the phenoxy radicals produced by wheat POD and was oxidized into cystine, while the other part of phenoxy radicals formed ferulate dimers.	Sulfhydryl Compounds	4-9	peroxidase-like	Triticum aestivum	71-74
12036910-6	2002	Although the S-nitrosylcysteine adduct in hAGT is readily reversible by reaction with other cellular thiols, the formation of S-nitrosocysteine at Cys-145 was found to lead to the rapid degradation of the hAGT protein in vivo.	Sulfhydryl Compounds	101-107	angiotensinogen	Homo sapiens	42-46
12039914-1	2002	The distinct thiol redox status in macrophages, either elevated or reduced intracellular content of glutathione (GSH), was confirmed during aging in IL-2 receptor (IL-2R)gamma and Janus family tyrosine kinase (JAK)3 gene-disrupted mice.	Sulfhydryl Compounds	13-18	interleukin 2 receptor, alpha chain	Mus musculus	164-169
12039914-1	2002	The distinct thiol redox status in macrophages, either elevated or reduced intracellular content of glutathione (GSH), was confirmed during aging in IL-2 receptor (IL-2R)gamma and Janus family tyrosine kinase (JAK)3 gene-disrupted mice.	Sulfhydryl Compounds	13-18	Janus kinase 3	Mus musculus	193-215
11904290-6	2002	Cellular thiols (e.g. thioredoxin) are used to regenerate the peroxiredoxins to their active state.	Sulfhydryl Compounds	9-15	thioredoxin	Homo sapiens	22-33
11904290-6	2002	Cellular thiols (e.g. thioredoxin) are used to regenerate the peroxiredoxins to their active state.	Sulfhydryl Compounds	9-15	peroxiredoxin 2	Homo sapiens	62-76
11991848-5	2002	New data is presented that directly measure the pKa of hyperreactive thiols that occur when the closed conformation of the RyR channel complex is assumed, and that appear to be an integral component of the redox sensor.	Sulfhydryl Compounds	69-75	ryanodine receptor 2	Homo sapiens	123-126
12076523-5	2002	Therefore, the aim of this work was to study the effects of antioxidants and thiol protecting agents on MPT promoted by VP-16, attempting to identify the underlying mechanisms on VP-16-induced apoptosis.	Sulfhydryl Compounds	77-82	host cell factor C1	Homo sapiens	120-125
12076523-7	2002	The thiol reagents GSH, dithiothreitol and N-ethylmaleimide, which have been reported to prevent the MPT induction, also protect this event promoted by VP-16.	Sulfhydryl Compounds	4-9	host cell factor C1	Homo sapiens	152-157
12144532-6	2002	It was demonstrated that those highly reactive species oxidise lipids, cell surface protein thiols or activate transcriptional factors such as Nuclear Factor kappaB (NFkappaB).	Sulfhydryl Compounds	92-98	nuclear factor kappa B subunit 1	Homo sapiens	143-164
12144532-6	2002	It was demonstrated that those highly reactive species oxidise lipids, cell surface protein thiols or activate transcriptional factors such as Nuclear Factor kappaB (NFkappaB).	Sulfhydryl Compounds	92-98	nuclear factor kappa B subunit 1	Homo sapiens	166-174
12009892-7	2002	LRAT monomers can be efficiently and irreversibly cross-linked by thiol reactive bismaleimides in retinal pigment epithelial (RPE) membranes generating LRAT homodimers.	Sulfhydryl Compounds	66-71	lecithin retinol acyltransferase	Homo sapiens	0-4
12009892-7	2002	LRAT monomers can be efficiently and irreversibly cross-linked by thiol reactive bismaleimides in retinal pigment epithelial (RPE) membranes generating LRAT homodimers.	Sulfhydryl Compounds	66-71	lecithin retinol acyltransferase	Homo sapiens	152-156
11872752-10	2002	The pK(a) of the thiol group of active-site-bound glutathione, 6.1, increased to 6.5 in GST A3-3/Y9F.	Sulfhydryl Compounds	17-22	glutathione S-transferase alpha 3	Homo sapiens	88-96
12007958-15	2002	CONCLUSIONS: The redox-sensitive transcription factor NFkappaB can be activated in U87 glioma cells by the active thiol form of the cytoprotector amifostine.	Sulfhydryl Compounds	114-119	nuclear factor kappa B subunit 1	Homo sapiens	54-62
11952335-5	2002	In the present study, we have evaluated the reactivity of PCB metabolites with other nucleophiles, like glutathione (GSH), by assessing (1) quantitative GSH binding in vitro, (2) GSH and thiol (sulfhydryl) depletion in HL-60 cells, (3) the associated cytotoxicity, and (4) the inhibition of topoisomerase II activity in vitro.	Sulfhydryl Compounds	187-192	pyruvate carboxylase	Homo sapiens	58-61
11985869-6	2002	Here we show that S. mansoni possess an unusual thiol redox system centered on thioredoxin glutathione reductase.	Sulfhydryl Compounds	48-53	thioredoxin glutathione reductase	Schistosoma mansoni	79-112
12062443-6	2002	These results rationalise conflicting reports of the sensitivity of caspase-3 to H2O2, and identify a novel mechanism for sensitising a thiol enzyme to oxidative inactivation.	Sulfhydryl Compounds	136-141	caspase 3	Homo sapiens	68-77
11986364-0	2002	Mechanism of Kir6.2 channel inhibition by sulfhydryl modification: pore block or allosteric gating?	Sulfhydryl Compounds	42-52	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	13-19
12164547-8	2002	Several presynaptic thiol-containing proteins (e.g. SNAP-25, NSF) are critically involved in formation of SNARE (soluble N-ethylmaleimide (NEM)-sensitive fusion protein receptor) complexes that mediate membrane fusion processes such as exocytosis and turnover of plasmalemmal proteins and other constituents.	Sulfhydryl Compounds	20-25	synaptosome associated protein 25	Homo sapiens	52-59
12164547-8	2002	Several presynaptic thiol-containing proteins (e.g. SNAP-25, NSF) are critically involved in formation of SNARE (soluble N-ethylmaleimide (NEM)-sensitive fusion protein receptor) complexes that mediate membrane fusion processes such as exocytosis and turnover of plasmalemmal proteins and other constituents.	Sulfhydryl Compounds	20-25	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	61-64
11916399-4	2002	A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-mercaptoethanol activation, to C-5 of the uracil at the U9 position of the RNA 11-mer, oxidation by dioxygen, reduction by the thiol, and subsequent dehydration is proposed for adduct formation.	Sulfhydryl Compounds	210-215	complement C6	Homo sapiens	55-58
11916399-4	2002	A novel mechanism involving adduction of the NCS-chrom C-6 radical, generated by 2-mercaptoethanol activation, to C-5 of the uracil at the U9 position of the RNA 11-mer, oxidation by dioxygen, reduction by the thiol, and subsequent dehydration is proposed for adduct formation.	Sulfhydryl Compounds	210-215	complement C5	Homo sapiens	114-117
11893559-5	2002	One week of treatment of GPx-1(-/-) mice with L-2-oxothiazolidine-4-carboxylic acid (OTC), which increases intracellular thiol pools, resulted in restoration of normal vascular reactivity in the mesenteric bed of GPx-1(-/-) mice.	Sulfhydryl Compounds	121-126	glutathione peroxidase 1	Mus musculus	25-30
11983337-0	2002	Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe.	Sulfhydryl Compounds	108-113	coagulation factor X	Homo sapiens	36-45
11952335-5	2002	In the present study, we have evaluated the reactivity of PCB metabolites with other nucleophiles, like glutathione (GSH), by assessing (1) quantitative GSH binding in vitro, (2) GSH and thiol (sulfhydryl) depletion in HL-60 cells, (3) the associated cytotoxicity, and (4) the inhibition of topoisomerase II activity in vitro.	Sulfhydryl Compounds	194-204	pyruvate carboxylase	Homo sapiens	58-61
11983337-0	2002	Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe.	Sulfhydryl Compounds	108-113	coagulation factor II, thrombin	Homo sapiens	50-61
11983337-2	2002	Here, the formation of the factor Xa*prothrombin complex and the effects of factor Va on this complex were examined using a photoactivable thiol-specific fluorescent probe (LWB), which was synthesized and incorporated into the active site of factor Xa.	Sulfhydryl Compounds	139-144	coagulation factor X	Homo sapiens	27-36
11983337-2	2002	Here, the formation of the factor Xa*prothrombin complex and the effects of factor Va on this complex were examined using a photoactivable thiol-specific fluorescent probe (LWB), which was synthesized and incorporated into the active site of factor Xa.	Sulfhydryl Compounds	139-144	coagulation factor X	Homo sapiens	242-251
11929854-0	2002	Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro.	Sulfhydryl Compounds	43-48	frataxin	Homo sapiens	0-8
11909693-4	2002	We show here that oxidoreductase-mediated modulations of the cell surface thiol status affect the enzymatic activity of APN.	Sulfhydryl Compounds	74-79	thioredoxin reductase 1	Homo sapiens	18-32
11909693-4	2002	We show here that oxidoreductase-mediated modulations of the cell surface thiol status affect the enzymatic activity of APN.	Sulfhydryl Compounds	74-79	alanyl aminopeptidase, membrane	Homo sapiens	120-123
11909699-4	2002	Simultaneous incubation with the thiol antioxidant N-acetylcysteine (NAC) inhibited indomethacin-mediated increases in GCLC mRNA, suggesting that increases in GCLC message were triggered by changes in intracellular oxidation/reduction (redox) reactions.	Sulfhydryl Compounds	33-38	glutamate-cysteine ligase catalytic subunit	Homo sapiens	119-123
11909699-4	2002	Simultaneous incubation with the thiol antioxidant N-acetylcysteine (NAC) inhibited indomethacin-mediated increases in GCLC mRNA, suggesting that increases in GCLC message were triggered by changes in intracellular oxidation/reduction (redox) reactions.	Sulfhydryl Compounds	33-38	glutamate-cysteine ligase catalytic subunit	Homo sapiens	159-163
11929854-3	2002	Here we demonstrate that transgenic overexpression of human frataxin increases cellular antioxidant defense via activation of glutathione peroxidase and elevation of reduced thiols, thereby reducing the incidence of malignant transformation induced by ROS, as observed by soft agar assays and tumour formation in nude mice.	Sulfhydryl Compounds	174-180	frataxin	Homo sapiens	60-68
11869872-7	2002	A remarkable increase in GST activity might be a compensatory up-regulation to detoxify Mannich bases by conjugating them with cellular thiols.	Sulfhydryl Compounds	136-142	glutathione S-transferase kappa 1	Homo sapiens	25-28
11910036-0	2002	Free-thiol Cys331 exposed during activation process is critical for native tetramer structure of cathepsin C (dipeptidyl peptidase I).	Sulfhydryl Compounds	5-10	cathepsin C	Bos taurus	97-108
11796729-1	2002	Defense against oxidative stress in mammals includes the regeneration of the major thiol reductants glutathione and thioredoxin by glutathione reductase and thioredoxin reductase (TrxR), respectively.	Sulfhydryl Compounds	83-88	uncharacterized protein	Drosophila melanogaster	116-127
11796729-1	2002	Defense against oxidative stress in mammals includes the regeneration of the major thiol reductants glutathione and thioredoxin by glutathione reductase and thioredoxin reductase (TrxR), respectively.	Sulfhydryl Compounds	83-88	Thioredoxin reductase-1	Drosophila melanogaster	131-152
11796729-1	2002	Defense against oxidative stress in mammals includes the regeneration of the major thiol reductants glutathione and thioredoxin by glutathione reductase and thioredoxin reductase (TrxR), respectively.	Sulfhydryl Compounds	83-88	Thioredoxin reductase-1	Drosophila melanogaster	157-178
11788599-4	2002	Using a Chinese hamster ovary G6PD-null mutant, we previously demonstrated that exposure to a thiol-specific oxidant, hydroxyethyldisulfide, caused enhanced radiation sensitivity and an inability to repair DNA double strand breaks.	Sulfhydryl Compounds	94-99	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	30-34
11906178-3	2002	DNase IIalpha purified from porcine spleen was previously shown to contain three peptides, two of which were thiol crosslinked, all derived by processing of a single polypeptide.	Sulfhydryl Compounds	109-114	deoxyribonuclease 2, lysosomal	Homo sapiens	0-13
11782484-0	2002	Plasmin reduction by phosphoglycerate kinase is a thiol-independent process.	Sulfhydryl Compounds	50-55	plasminogen	Homo sapiens	0-7
12061835-8	2002	We conclude that thiol levels regulate IL-12 p75 production and that assembly of the heterodimer is a step that might represent a target for pharmacological intervention.	Sulfhydryl Compounds	17-22	interleukin 2 receptor subunit beta	Homo sapiens	45-48
11782484-7	2002	Alkylation/oxidation of Cys-379 and -380 by four different thiol-reactive compounds reduced plasmin reductase activity to 7--35% of control.	Sulfhydryl Compounds	59-64	plasminogen	Homo sapiens	92-99
11782484-10	2002	In summary, reduction of plasmin by PGK is a thiol-independent process, although either alkylation/oxidation of the fast-reacting Cys near the hinge or hinge bending conformational change in PGK perturbs plasmin reduction by PGK, perhaps by obstructing the interaction of plasmin with PGK or perturbing conformational changes in PGK required for plasmin reduction.	Sulfhydryl Compounds	45-50	plasminogen	Homo sapiens	25-32
12071352-4	2002	The purpose of this study has been to establish the effect of the thiol compounds N-acetyl-L-cysteine (NAC) and glutathione (GSH) against the peroxidative processes involving membrane lipids.	Sulfhydryl Compounds	66-71	X-linked Kx blood group	Homo sapiens	103-106
11861267-0	2002	Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O(2) chemosensitivity.	Sulfhydryl Compounds	118-123	erythropoietin	Homo sapiens	68-82
11861267-4	2002	The hypothesis that HVR and EPO production are modulated by thiol compounds or changes in the plasma thiol-disulfide redox state (REDST) was investigated.	Sulfhydryl Compounds	60-65	erythropoietin	Homo sapiens	28-31
11888918-1	2002	Thiol antioxidants, typified by N-acetyl cysteine, are known to induce p53-dependent apoptosis in transformed mouse embryo fibroblasts but not in normal mouse embryo fibroblasts.	Sulfhydryl Compounds	0-5	transformation related protein 53, pseudogene	Mus musculus	71-74
11896678-12	2002	Thus, the effect of Cu(II) must be due to its reaction with Cys-39 bearing the only thiol group in Fhit monomer.	Sulfhydryl Compounds	84-89	fragile histidine triad diadenosine triphosphatase	Homo sapiens	99-103
12033454-0	2002	Irreversible thiol oxidation in carbonic anhydrase III: protection by S-glutathiolation and detection in aging rats.	Sulfhydryl Compounds	13-18	carbonic anhydrase 3	Rattus norvegicus	32-54
11890743-9	2002	The results demonstrate that cdb3 and GAPD contain reactive thiols that can be transnitrosylated mainly by means of GSNO; these can ultimately influence GAPD translocation/activity and the glycolytic flux.	Sulfhydryl Compounds	60-66	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	38-42
12033454-5	2002	H202 and peroxyl radicals both generated S-glutathiolated carbonic anhydrase III via partially oxidized protein sulfhydryl intermediates, while HOCl did not cause S-glutathiolation.	Sulfhydryl Compounds	112-122	carbonic anhydrase 3	Rattus norvegicus	58-80
11868814-12	2002	We conclude that the hyaluronidase activity of sperm surface PH-20 is dependent on structural features established by sulfhydryl linkages, as well as glycosylation.	Sulfhydryl Compounds	118-128	sperm adhesion molecule 1	Homo sapiens	61-66
11859152-0	2002	Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization.	Sulfhydryl Compounds	0-5	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	110-119
11859152-4	2002	Of the six agents tested, only the thiol antioxidants, BUC and NAC, were effective at preventing a decrease in intracellular reduced glutathione:glutathione disulfide ratios, protecting cells from protein and lipid oxidation, and preventing heme oxygenase 1 expression.	Sulfhydryl Compounds	35-40	heme oxygenase 1	Mus musculus	241-257
11857495-1	2002	Peroxiredoxins (Prxs) are a recently characterized group of thiol-containing proteins with efficient antioxidant capacity, capable of consuming hydrogen peroxide in living cells.	Sulfhydryl Compounds	60-65	peroxiredoxin 1	Homo sapiens	0-14
12018622-2	2002	Under denaturing conditions and in the presence of a thiol catalyst, the native EGF denatures by shuffling its three native disulfide bonds and converts to a mixture of scrambled isomers.	Sulfhydryl Compounds	53-58	epidermal growth factor	Homo sapiens	80-83
11882710-0	2002	Evidence that ORF3 at the Streptococcus parasanguis fimA locus encodes a thiol-specific antioxidant.	Sulfhydryl Compounds	73-78	hypothetical protein	Escherichia coli	14-18
11890743-2	2002	In this study we have investigated which NO-reactive thiols might be influencing GAPD translocation and the specific role of glutathione.	Sulfhydryl Compounds	53-59	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	81-85
11870126-6	2002	Patients of groups 1 and 2 with GST M1- genotype had significantly higher 8-OHdG content in sperm DNA and lower protein thiols and ascorbic acid in seminal plasma than those with GST M1+ genotype.	Sulfhydryl Compounds	120-126	glutathione S-transferase mu 1	Homo sapiens	32-38
11890743-9	2002	The results demonstrate that cdb3 and GAPD contain reactive thiols that can be transnitrosylated mainly by means of GSNO; these can ultimately influence GAPD translocation/activity and the glycolytic flux.	Sulfhydryl Compounds	60-66	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	153-157
11839698-4	2002	The isolated a and a" domains of PDI are good catalysts of simple thiol-disulfide interchange reactions but require additional domains to be effective as catalysts of the rate-limiting disulfide isomerizations in protein folding pathways.	Sulfhydryl Compounds	66-71	protein disulfide isomerase family A member 2	Homo sapiens	33-36
11882947-8	2002	The levels of the major cellular thiol compounds cysteine and glutathione in leaves and seedlings of A. thaliana are compatible with a physiological role of H2O2 in regulating ABI2 activity.	Sulfhydryl Compounds	33-38	Protein phosphatase 2C family protein	Arabidopsis thaliana	176-180
11857348-0	2002	Extra-cellular thiol metabolism in clones of human metastatic melanoma with different gamma-glutamyl transpeptidase expression: implications for cell response to platinum-based drugs.	Sulfhydryl Compounds	15-20	inactive glutathione hydrolase 2	Homo sapiens	86-115
11857348-2	2002	The plasma membrane enzyme gamma-glutamyl transpeptidase (GGT), which plays a crucial role in cellular handling of thiols, is often expressed in malignant tumors, including melanoma, although its expression levels may vary widely among different tumors or cells of the same tumor.	Sulfhydryl Compounds	115-121	inactive glutathione hydrolase 2	Homo sapiens	27-56
11857348-2	2002	The plasma membrane enzyme gamma-glutamyl transpeptidase (GGT), which plays a crucial role in cellular handling of thiols, is often expressed in malignant tumors, including melanoma, although its expression levels may vary widely among different tumors or cells of the same tumor.	Sulfhydryl Compounds	115-121	inactive glutathione hydrolase 2	Homo sapiens	58-61
11857348-12	2002	These results suggest that the clone-specific balance between transport of sulfur aminoacids and GGT activity results in profound differences in the capability of each clone to modify the thiol redox status of the extracellular milieu.	Sulfhydryl Compounds	188-193	inactive glutathione hydrolase 2	Homo sapiens	97-100
11779571-1	2002	Reaction of the melanotropin hormone analogs [Nle(4),D-Phe(7)]-alpha-MSH and [Nle(4),D-Phe(7)]-alpha-MSH(4-10), which were extended at their N-terminus by a thiol-functionalized spacer arm, with preformed liposomes containing thiol-reactive (phospho)lipid derivatives resulted in the aggregation of the vesicles and in a partial leakage of their inner contents.	Sulfhydryl Compounds	157-162	proopiomelanocortin	Homo sapiens	95-104
11779571-1	2002	Reaction of the melanotropin hormone analogs [Nle(4),D-Phe(7)]-alpha-MSH and [Nle(4),D-Phe(7)]-alpha-MSH(4-10), which were extended at their N-terminus by a thiol-functionalized spacer arm, with preformed liposomes containing thiol-reactive (phospho)lipid derivatives resulted in the aggregation of the vesicles and in a partial leakage of their inner contents.	Sulfhydryl Compounds	226-231	proopiomelanocortin	Homo sapiens	95-104
11851405-1	2002	We present here evidence that redox-dependent thiol-disulfide exchange can provide a mechanism regulating the conformation and activity of the human heat shock transcription factor 1 (HSF1).	Sulfhydryl Compounds	46-51	heat shock transcription factor 1	Homo sapiens	149-182
11851405-1	2002	We present here evidence that redox-dependent thiol-disulfide exchange can provide a mechanism regulating the conformation and activity of the human heat shock transcription factor 1 (HSF1).	Sulfhydryl Compounds	46-51	heat shock transcription factor 1	Homo sapiens	184-188
11679582-2	2002	CD38 internalization has been proposed as a mechanism by which the ectoenzyme produced intracellular cADPR, and thiol compounds have been shown to induce the internalization of CD38.	Sulfhydryl Compounds	112-117	CD38 antigen	Mus musculus	0-4
11679582-2	2002	CD38 internalization has been proposed as a mechanism by which the ectoenzyme produced intracellular cADPR, and thiol compounds have been shown to induce the internalization of CD38.	Sulfhydryl Compounds	112-117	CD38 antigen	Mus musculus	177-181
11827556-9	2002	The results indicate that incorporation of a free thiol within an amphipathic alpha helix of apoA-I confers an antioxidant activity distinct from that of apoA-I(WT).	Sulfhydryl Compounds	50-55	apolipoprotein A1	Homo sapiens	93-99
11792859-6	2002	Fewer extracellular thiols are recovered after DC-T cell interactions when cystine uptake or TRX activity are inhibited.	Sulfhydryl Compounds	20-26	thioredoxin	Homo sapiens	93-96
11934392-1	2002	Cholesteryl ester transfer protein (CETP) has at least one unpaired sulfhydryl residue, which we have shown previously to be in or near the active site region.	Sulfhydryl Compounds	68-78	cholesteryl ester transfer protein	Homo sapiens	0-34
11934392-1	2002	Cholesteryl ester transfer protein (CETP) has at least one unpaired sulfhydryl residue, which we have shown previously to be in or near the active site region.	Sulfhydryl Compounds	68-78	cholesteryl ester transfer protein	Homo sapiens	36-40
11934392-2	2002	We investigated the location of this unpaired cysteine residue(s) of CETP using chemical modification with fluorescent sulfhydryl-specific reagents, limited proteolysis, and amino acid/sequence analysis.	Sulfhydryl Compounds	119-129	cholesteryl ester transfer protein	Homo sapiens	69-73
11935325-9	2002	On the basis of predictions from molecular modeling of the X-ray crystallographic structure of chick smooth muscle myosin, the mutated thiol reactive group of R702C may lead to intermolecular disulfide bridges, with the consequent formation of the inclusions typical of FTNS.	Sulfhydryl Compounds	135-140	myosin, heavy chain 9, non-muscle	Gallus gallus	115-121
11826045-6	2002	Alkylation of free thiols with N-ethylmaleimide prevented the actions of papa-NONOate, suggesting that NO, or a related reactive nitrogen species, modifies sulfhydryl groups on Na+ channels or a closely associated protein.	Sulfhydryl Compounds	19-25	pappalysin 1	Homo sapiens	73-77
11820942-3	2002	RTA was coupled to the dextran gel matrix on the sensor chip surface through a single thiol group that is not involved in the enzymatic action.	Sulfhydryl Compounds	86-91	RT1 class I, locus A	Rattus norvegicus	0-3
11841562-4	2002	Parkinson"s disease is also characterized by decreases in midbrain levels of total glutathione which could impact on E1 enzyme activity via oxidation of the active site sulfhydryl.	Sulfhydryl Compounds	169-179	enolase-phosphatase 1	Rattus norvegicus	117-126
11841832-1	2002	Thioredoxin (TRX) is a small ubiquitous protein with multiple biological functions, including the thiol-mediated redox-regulation of gene expression.	Sulfhydryl Compounds	98-103	thioredoxin	Homo sapiens	0-11
11809868-0	2002	The thiol sensitivity of glutathione transport in sidedness-sorted basolateral liver plasma membrane and in Oatp1-expressing HeLa cell membrane.	Sulfhydryl Compounds	4-9	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	108-113
11809868-2	2002	Rat organic anion transporter polypeptide1 (Oatp1) is known to transport GSH but several features of sinusoidal GSH uptake, such as electrogenic property and asymmetric effects of uncharged thiols (increased efflux, decreased uptake), either cannot be accounted for by Oatp1 or have not been studied.	Sulfhydryl Compounds	190-196	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	44-49
11809868-5	2002	We also studied the kinetics and effect of thiols on GSH transport by Oatp1 stably expressed in HeLa cells.	Sulfhydryl Compounds	43-49	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	70-75
11809868-11	2002	In contrast, GSH transport mediated by Oatp1 was insensitive to thiols and membrane potential, inhibited by cystine, and stimulated by an inward H(+) gradient.	Sulfhydryl Compounds	64-70	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	39-44
11841837-4	2002	Dethiolation is dependent on the availability of GSH and thiols, since it is inhibited by GSH-depleting agents and improved by N-acetyl-L-cysteine (NAC).	Sulfhydryl Compounds	57-63	X-linked Kx blood group	Homo sapiens	148-151
11841832-1	2002	Thioredoxin (TRX) is a small ubiquitous protein with multiple biological functions, including the thiol-mediated redox-regulation of gene expression.	Sulfhydryl Compounds	98-103	thioredoxin	Homo sapiens	13-16
11841834-0	2002	Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging.	Sulfhydryl Compounds	14-19	negative elongation factor complex member C/D, Th1l	Mus musculus	60-63
11841834-0	2002	Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging.	Sulfhydryl Compounds	14-19	thioredoxin 1	Mus musculus	75-86
11883601-3	2002	In this work, the effect of the photooxidation of membrane thiol groups on the lysosomal osmotic sensitivity was studied by measuring the thiol groups with 5,5"-dithiobis(2-nitrobenzoic acid) and examining the lysosomal beta-hexosaminidase latency loss in a hypotonic sucrose medium.	Sulfhydryl Compounds	59-64	O-GlcNAcase	Homo sapiens	220-239
11782142-5	2002	As the maleimide group can react with the sulfhydryl group to form a stable thioether moiety, these complexes have been used as thiol-specific luminescent labels for a thiolated oligonucleotide, glutathione, and bovine serum albumin and human serum albumin.	Sulfhydryl Compounds	128-133	albumin	Homo sapiens	219-232
11814595-1	2002	Phytochelatin synthase is the enzyme responsible for the synthesis of heavy-metal-binding peptides (phytochelatins) from glutathione and related thiols.	Sulfhydryl Compounds	145-151	Glutathione gamma-glutamylcysteinyltransferase	Caenorhabditis elegans	0-22
11803031-10	2002	Moreover, thiol oxidation of rat RBC was strictly related to methemoglobin formation.	Sulfhydryl Compounds	10-15	hemoglobin subunit gamma 2	Homo sapiens	61-74
11698397-1	2002	The ability of copper,zinc superoxide dismutase (Cu,Zn-SOD) to catalyze autoxidation of cysteine and other thiols was investigated by measuring thiol loss and oxygen consumption.	Sulfhydryl Compounds	107-113	superoxide dismutase 1	Homo sapiens	55-58
11698397-1	2002	The ability of copper,zinc superoxide dismutase (Cu,Zn-SOD) to catalyze autoxidation of cysteine and other thiols was investigated by measuring thiol loss and oxygen consumption.	Sulfhydryl Compounds	107-112	superoxide dismutase 1	Homo sapiens	55-58
11698397-5	2002	With 1 mm thiol and 40 microg/ml SOD, rates of oxidation of other thiols (microm/min) were as follows: GSH, 1.0; dithiothreitol, 2.1; dihydrolipoic acid, 1.7; homocysteine, 1.6; cys-gly, 1.4; penicillamine, 0.6; and N-acetylcysteine, 0.1.	Sulfhydryl Compounds	66-72	superoxide dismutase 1	Homo sapiens	33-36
11698397-8	2002	SOD-catalyzed oxidation of the other thiols was variably affected by adventitious metal ions and chelating agents.	Sulfhydryl Compounds	37-43	superoxide dismutase 1	Homo sapiens	0-3
11698397-10	2002	SOD-catalyzed oxidation of GSH and homocysteine was enhanced by cysteine through a thiol-disulfide exchange mechanism.	Sulfhydryl Compounds	83-88	superoxide dismutase 1	Homo sapiens	0-3
11782142-5	2002	As the maleimide group can react with the sulfhydryl group to form a stable thioether moiety, these complexes have been used as thiol-specific luminescent labels for a thiolated oligonucleotide, glutathione, and bovine serum albumin and human serum albumin.	Sulfhydryl Compounds	128-133	albumin	Homo sapiens	243-256
11684695-3	2002	Human ACAT1 contains nine cysteine residues; its activity is severely inhibited by various thiol-specific modification reagents including p-chloromercuribenzene sulfonic acid, suggesting that certain cysteine residue(s) might be near or at the active site.	Sulfhydryl Compounds	91-96	acetyl-CoA acetyltransferase 1	Homo sapiens	6-11
12040965-1	2002	Zofenopril calcium (CAS 81938-43-4) is a new angiotensin converting enzyme (ACE) inhibitor, which in addition to the typical activity of the class, proved to possess a specific cardioprotective effect due also to the presence of the sulfhydryl group.	Sulfhydryl Compounds	233-243	angiotensin I converting enzyme	Homo sapiens	45-74
11560938-3	2002	Under strong denaturing conditions (e.g. 6 m guanidinium chloride) and in the presence of a thiol initiator, alpha-lactalbumin (alphaLA) denatures by shuffling its four native disulfide bonds and converts to an assembly of 45 species of scrambled isomers.	Sulfhydryl Compounds	92-97	lactalbumin alpha	Homo sapiens	109-126
12040965-1	2002	Zofenopril calcium (CAS 81938-43-4) is a new angiotensin converting enzyme (ACE) inhibitor, which in addition to the typical activity of the class, proved to possess a specific cardioprotective effect due also to the presence of the sulfhydryl group.	Sulfhydryl Compounds	233-243	angiotensin I converting enzyme	Homo sapiens	76-79
11790955-2	2002	The relative reduction-oxidation state of the cell depends primarily on the precise balance between concentrations of reactive oxygen species and the cysteine-dependent antioxidant thiol buffers glutathione and thioredoxin, which by preferentially reacting with reactive oxygen species, protect other intracellular molecules from oxidative damage.	Sulfhydryl Compounds	181-186	thioredoxin	Homo sapiens	211-222
11792184-1	2002	The immobilization of thiol-derivatized DNA on a Au (111) single crystal surface by self-assembly has been investigated by electrochemical scanning tunneling microscopy (EC-STM).	Sulfhydryl Compounds	22-27	sulfotransferase family 1A member 3	Homo sapiens	173-176
11792185-2	2002	We have synthesized a bifunctional vinyl sulfone-cysteineamido derivative of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) that can be conjugated to the sulfhydryls of mildly reduced recombinant antibody (chimeric anti-CEA antibody cT84.66) at pH 7 or to the amino groups of lysine residues at pH 9.	Sulfhydryl Compounds	171-182	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	237-240
11754734-4	2002	The conformation of the reduced beta2M in the absence of denaturant at pH 8.5 was similar to that of the intact protein unless the thiol groups were modified.	Sulfhydryl Compounds	131-136	beta-2-microglobulin	Homo sapiens	32-38
11784324-4	2002	The formation of a covalently-linked hexamer of HABP1 through Cys186 as a dimer of trimers is achieved by thiol group oxidation, which can be blocked by modification of Cys186.	Sulfhydryl Compounds	106-111	complement C1q binding protein	Homo sapiens	48-53
11740866-2	2002	We found that activation of ECV-304 cells by TNFalpha was accompanied by a transient burst of oxidants and activation of JNK, both of which were suppressed by two distinct inhibitors of the phagocyte NADPH oxidase and the thiol antioxidant N-acetyl cysteine (NAC).	Sulfhydryl Compounds	222-227	tumor necrosis factor	Homo sapiens	45-53
11740866-2	2002	We found that activation of ECV-304 cells by TNFalpha was accompanied by a transient burst of oxidants and activation of JNK, both of which were suppressed by two distinct inhibitors of the phagocyte NADPH oxidase and the thiol antioxidant N-acetyl cysteine (NAC).	Sulfhydryl Compounds	222-227	mitogen-activated protein kinase 8	Homo sapiens	121-124
11999701-7	2002	These effects which seem to be linked to a modulation of NF-kappaB, suggest that the improvement of immune functions observed in previous work after injection of NAC to animals with endotoxic shock could be due to a direct action of this thiol antioxidant on immune cells.	Sulfhydryl Compounds	238-243	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
12002676-4	2002	On the other hand, thiol excess (2-mercaptoethanol concentrations higher than 300 microM) induced apoptosis in 38C13 cells and EL4 cells as well as in other cells (e.g. Raji, HeLa).	Sulfhydryl Compounds	19-24	epilepsy 4	Mus musculus	127-130
12002676-9	2002	Apoptosis induction by thiol excess was associated with a certain decrease in the Bcl-2 level while the Bax level did not change.	Sulfhydryl Compounds	23-28	B cell leukemia/lymphoma 2	Mus musculus	82-87
11752136-4	2002	By reacting free thiols with 4-acetamido-4"-malemideylstilbene-2,2"-disulfonic acid, alkylated and nonalkylated disulfide-bonded forms of G4L could be resolved from each other by polyacrylamide gel electrophoresis.	Sulfhydryl Compounds	17-23	glutaredoxin-like protein	Vaccinia virus	138-141
12112029-7	2002	The effect of regucalcin (10(-8) M) in increasing microsomal Ca(2+)-ATPase activity was completely prevented in the presence of digitonin (10(-3) or 10(-2)%), which has a solubilizing effect on membranous lipid, or N-ethylmaleimide (NEM), a modifying reagent of sulfhydryl (SH) groups.	Sulfhydryl Compounds	262-272	regucalcin	Rattus norvegicus	14-24
12230917-3	2002	Application of "class-specific" protease inhibitors revealed that a thiol/cysteine was involved in the biochemical production of soluble CD14 fractions and that a metalloprotease enzymatically degraded soluble CD14 fragment.	Sulfhydryl Compounds	68-73	CD14 molecule	Homo sapiens	137-141
11885270-0	2002	S-glutathionylation of glyceraldehyde-3-phosphate dehydrogenase: role of thiol oxidation and catalysis by glutaredoxin.	Sulfhydryl Compounds	73-78	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	23-63
11921701-4	2002	Six months of treatment with epoetin was followed by significant increases in thiol groups, superoxide dismutase and glutathione peroxidase activities in both plasma and red blood cells of hemodialyzed patients.	Sulfhydryl Compounds	78-83	erythropoietin	Homo sapiens	29-36
11814878-1	2002	N-Bromosuccinimide (NBS) is a known protein reagent able to modify amino acids and proteins, resulting in oxidation of tryptophan, tyrosine and histidine residues, as well as sulfhydryl, alcohol and phenol groups.	Sulfhydryl Compounds	175-185	nibrin	Homo sapiens	20-23
12031340-5	2002	We suggest that the ratio between free sulfhydryl groups and disulfide bonds of the cysteine residues of VR1 pre-sets sensitivity of primary nociceptors to algogens and may represent a new target for treating some pain states in humans.	Sulfhydryl Compounds	39-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-108
11917294-0	2002	Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine"s free thiol in human microvascular endothelial and glioma cells.	Sulfhydryl Compounds	115-120	nuclear factor kappa B subunit 1	Homo sapiens	27-62
12189052-7	2002	We propose that phosphoglycerate kinase facilitates cleavage of a particular plasmin disulfide bond by hydroxide ion, which results in formation of a sulfenic acid and a free thiol.	Sulfhydryl Compounds	175-180	plasminogen	Homo sapiens	77-84
11641398-9	2001	In addition, these data suggest the involvement of a thiol-sensitive mechanism in the regulation of VEGF mRNA expression and HIF-1alpha protein in human ovarian cancer cells.	Sulfhydryl Compounds	53-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-135
11641398-9	2001	In addition, these data suggest the involvement of a thiol-sensitive mechanism in the regulation of VEGF mRNA expression and HIF-1alpha protein in human ovarian cancer cells.	Sulfhydryl Compounds	53-58	vascular endothelial growth factor A	Homo sapiens	100-104
11732921-0	2001	Folding of a disulfide-bonded protein species with free thiol(s): competition between conformational folding and disulfide reshuffling in an intermediate of bovine pancreatic ribonuclease A.	Sulfhydryl Compounds	56-61	ribonuclease pancreatic	Bos taurus	175-189
11747461-2	2001	The catalytic efficiency of human glutathione transferase A1-1 (GST A1-1) in the conjugation reaction with 1-chloro-2,4-dinitrobenzene is reduced 15 000-fold if the decarboxylated analogue of glutathione, dGSH (GABA-Cys-Gly), is used as an alternative thiol substrate.	Sulfhydryl Compounds	252-257	glutathione S-transferase alpha 1	Homo sapiens	64-72
11747461-4	2001	The pK(a) value of the thiol group of the natural substrate glutathione decreases from 9.2 to 6.7 upon binding to GST A1-1.	Sulfhydryl Compounds	23-28	glutathione S-transferase alpha 1	Homo sapiens	114-122
11749968-1	2001	The specific role of cytosolic thioredoxin peroxidase I (cTPx I), encoded by TSA1 (thiol-specific antioxidant), was investigated in the oxidative stress response of Saccharomyces cerevisiae.	Sulfhydryl Compounds	83-88	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	77-81
11728451-3	2001	Three of four cysteines present in wild-type GCAP-1 were accessible to the thiol-modifying reagent 5,5"-dithio-bis-(2-nitrobenzoic acid) in the presence of Ca(2+).	Sulfhydryl Compounds	75-80	guanylate cyclase activator 2A	Homo sapiens	45-51
11733995-5	2001	The induction of phospho-ERK and growth inhibition were antagonized by thiol-containing anti-oxidants, but not by catalase, consistent with a possible arylating mechanism.	Sulfhydryl Compounds	71-76	mitogen-activated protein kinase 1	Homo sapiens	25-28
11728801-8	2001	The properties of TrxR in combination with the functions of Trx position this system at the core of cellular thiol redox control and antioxidant defense.	Sulfhydryl Compounds	109-114	peroxiredoxin 5	Homo sapiens	18-22
11728801-8	2001	The properties of TrxR in combination with the functions of Trx position this system at the core of cellular thiol redox control and antioxidant defense.	Sulfhydryl Compounds	109-114	thioredoxin	Homo sapiens	18-21
11606257-6	2001	Total thiol content in ALA-D was not significantly changed by most porphyrins under UV light, while all porphyrins increase total sulfhydryl groups in PBG-D (23-52% over the control values) indicating changes in the redox status of SH residues.	Sulfhydryl Compounds	6-11	aminolevulinate dehydratase	Bos taurus	23-28
11734582-2	2001	Thiol-reactive fluorescent probes attached to cysteine-containing apoA-I mutants are currently being used to investigate the "LCAT active" conformation of lipid-bound apoA-I.	Sulfhydryl Compounds	0-5	apolipoprotein A1	Homo sapiens	66-72
11734582-2	2001	Thiol-reactive fluorescent probes attached to cysteine-containing apoA-I mutants are currently being used to investigate the "LCAT active" conformation of lipid-bound apoA-I.	Sulfhydryl Compounds	0-5	lecithin-cholesterol acyltransferase	Homo sapiens	126-130
11734582-2	2001	Thiol-reactive fluorescent probes attached to cysteine-containing apoA-I mutants are currently being used to investigate the "LCAT active" conformation of lipid-bound apoA-I.	Sulfhydryl Compounds	0-5	apolipoprotein A1	Homo sapiens	167-173
12078477-11	2001	This was confirmed by the observation that thiol-reducing agents (NAC, cystein) were able to inhibit BH formation and were toxic to parasites in vitro.	Sulfhydryl Compounds	43-48	synuclein alpha	Homo sapiens	66-69
11813981-0	2001	Redox control of EBV infection: prevention by thiol-dependent modulation of functional CD21/EBV receptor expression.	Sulfhydryl Compounds	46-51	complement C3d receptor 2	Homo sapiens	87-91
11813981-2	2001	In this report, surface expression of CD21 on B and T cells was shown to be suppressed by a thiol-antioxidant, N-acetylcysteine (NAC), in a dose- and time-dependent manner.	Sulfhydryl Compounds	92-97	complement C3d receptor 2	Homo sapiens	38-42
11813981-7	2001	Other thiol-antioxidants, such as 2-mercaptoethanol, pyrrolidine dithiocarbamate, and glutathione, showed similar effect to NAC on CD21 expression.	Sulfhydryl Compounds	6-11	complement C3d receptor 2	Homo sapiens	131-135
11813981-8	2001	These results suggest the possible modulation of EBV infection via thiol-dependent redox control of CD21, and thiol-antioxidants may be good candidates for controlling EBV infection.	Sulfhydryl Compounds	67-72	complement C3d receptor 2	Homo sapiens	100-104
11533038-11	2001	Thiol oxidation was associated with autolytic cleavage of pro-MMP-7, strongly suggesting that oxygenation activates the latent enzyme.	Sulfhydryl Compounds	0-5	matrix metallopeptidase 7	Homo sapiens	62-67
11698299-10	2001	It is suggested that Syk activation in vivo could be mediated by PTP inhibition, itself resulting from thiol oxidation, as PTPs are known to be inhibited by oxidants.	Sulfhydryl Compounds	103-108	spleen associated tyrosine kinase	Homo sapiens	21-24
11698299-10	2001	It is suggested that Syk activation in vivo could be mediated by PTP inhibition, itself resulting from thiol oxidation, as PTPs are known to be inhibited by oxidants.	Sulfhydryl Compounds	103-108	protein tyrosine phosphatase receptor type U	Homo sapiens	65-68
11533038-13	2001	Thus, HOCl activates pro-MMP-7 by converting the thiol residue of the cysteine switch to sulfinic acid.	Sulfhydryl Compounds	49-54	matrix metallopeptidase 7	Homo sapiens	25-30
11719447-1	2001	The thiol N-acetyl-L-cysteine (NAC), an analogue and precursor of reduced glutathione, has cancer chemopreventive properties attributable to its nucleophilicity, antioxidant activity, and a variety of other mechanisms.	Sulfhydryl Compounds	4-9	X-linked Kx blood group	Homo sapiens	31-34
11713678-3	2001	The effect of high temperature on Emp47p localization, as well as the temperature sensitivity of the mutant strain on rich medium, appear to be caused by oxidative stress and are correlated with severe reductions in the intracellular levels of low-molecular-weight thiols.	Sulfhydryl Compounds	265-271	Emp47p	Saccharomyces cerevisiae S288C	34-40
11553608-9	2001	Pretreatment of ABA3 with a thiol-specific alkylating reagent inhibited its desulfurase activity.	Sulfhydryl Compounds	28-33	molybdenum cofactor sulfurase (LOS5) (ABA3)	Arabidopsis thaliana	16-20
11716699-2	2001	Several thiol-containing peptides were investigated by examining the correlation between the second-order rate constant of their addition onto PEG-diacrylate and the pK(a) of the thiols within a peptide.	Sulfhydryl Compounds	8-13	progestagen associated endometrial protein	Homo sapiens	143-146
11710577-4	2001	Resulting data demonstrate that *OH is produced during Fenton-like reactions involving thiols and GSH catabolism via GGT.	Sulfhydryl Compounds	87-93	gamma-glutamyltransferase light chain family member 3	Homo sapiens	117-120
11689476-2	2001	Higher NO concentrations, as synthesized by the inducible NO synthase (iNOS) during inflammatory processes, show additional effects: NO may react with O2, yielding nitrogen oxides like N2O3 that are able to nitrosate thiols.	Sulfhydryl Compounds	217-223	nitric oxide synthase 2	Homo sapiens	48-69
11689476-2	2001	Higher NO concentrations, as synthesized by the inducible NO synthase (iNOS) during inflammatory processes, show additional effects: NO may react with O2, yielding nitrogen oxides like N2O3 that are able to nitrosate thiols.	Sulfhydryl Compounds	217-223	nitric oxide synthase 2	Homo sapiens	71-75
11764282-1	2001	An important constituent of the cellular antioxidant buffering system that controls the redox state of proteins is thioredoxin (TRX), a 13 kDa protein that catalyzes thiol-disulfide exchange reactions, regulates activation of transcription factors, and possesses several other biologic functions similar to cytokines.	Sulfhydryl Compounds	166-171	thioredoxin	Homo sapiens	115-126
11764282-1	2001	An important constituent of the cellular antioxidant buffering system that controls the redox state of proteins is thioredoxin (TRX), a 13 kDa protein that catalyzes thiol-disulfide exchange reactions, regulates activation of transcription factors, and possesses several other biologic functions similar to cytokines.	Sulfhydryl Compounds	166-171	thioredoxin	Homo sapiens	128-131
11580274-0	2001	Thiol/disulfide interconversion in bovine lens aldose reductase induced by intermediates of glutathione turnover.	Sulfhydryl Compounds	0-5	aldose reductase	Bos taurus	47-63
11489908-1	2001	We report the use of thiol chemistry to define specific and reversible disulfide interactions of Cys-substituted NK2 receptor mutants with analogues of neurokinin A (NKA) containing single cysteine substitutions.	Sulfhydryl Compounds	21-26	tachykinin receptor 2	Homo sapiens	113-125
11489908-1	2001	We report the use of thiol chemistry to define specific and reversible disulfide interactions of Cys-substituted NK2 receptor mutants with analogues of neurokinin A (NKA) containing single cysteine substitutions.	Sulfhydryl Compounds	21-26	tachykinin precursor 1	Homo sapiens	152-164
11489908-1	2001	We report the use of thiol chemistry to define specific and reversible disulfide interactions of Cys-substituted NK2 receptor mutants with analogues of neurokinin A (NKA) containing single cysteine substitutions.	Sulfhydryl Compounds	21-26	tachykinin precursor 1	Homo sapiens	166-169
11580274-8	2001	A pathway of thiol/disulfide interconversion for bovine lens ALR2 induced, in oxidative conditions, by physiological thiol compounds is proposed.	Sulfhydryl Compounds	13-18	lens aldose reductase pseudogene	Bos taurus	61-65
11580274-2	2001	Disulfides of both thiol compounds appear to be very effective as ALR2 thiolating agents.	Sulfhydryl Compounds	19-24	lens aldose reductase pseudogene	Bos taurus	66-70
11580274-8	2001	A pathway of thiol/disulfide interconversion for bovine lens ALR2 induced, in oxidative conditions, by physiological thiol compounds is proposed.	Sulfhydryl Compounds	117-122	lens aldose reductase pseudogene	Bos taurus	61-65
11585853-2	2001	Using two-electrode voltage clamp, we tested for changes in N associated with activation of CFTR in Xenopus oocytes using a cysteine-substituted construct (R334C CFTR) that can be modified by externally applied, impermeant thiol reagents like [2-(trimethylammonium)ethyl] methanethiosulfonate bromide (MTSET+).	Sulfhydryl Compounds	223-228	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	Xenopus laevis	92-96
11518701-0	2001	Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers.	Sulfhydryl Compounds	84-89	ATP binding cassette subfamily B member 1	Homo sapiens	63-77
11585757-7	2001	Moreover, the thiol-antioxidants glutathione and N-acetyl-L-cysteine antagonized the Cpd 5-induced Cdk4 tyrosine phosphorylation, whereas the nonthiol-antioxidants catalase and superoxide dismutase did not.	Sulfhydryl Compounds	14-19	cyclin dependent kinase 4	Homo sapiens	99-103
11761336-0	2001	Effects of thiol antioxidants on hepatocyte growth factor signaling in cardiac myocytes.	Sulfhydryl Compounds	11-16	hepatocyte growth factor	Homo sapiens	33-57
11761336-3	2001	Pretreatment of cells with thiol antioxidants, N-acetylcysteine or alpha-lipoic acid attenuated MAPK phosphorylation induced by a 3-min incubation with HGF.	Sulfhydryl Compounds	27-32	hepatocyte growth factor	Homo sapiens	152-155
11761336-4	2001	However, kinetic analysis revealed that the apparent inhibition of HGF signaling was due to a delay in the activation because HGF phosphorylated MAPK with a peak at 5-7 min in cells treated with thiol antioxidants.	Sulfhydryl Compounds	195-200	hepatocyte growth factor	Homo sapiens	67-70
11761336-4	2001	However, kinetic analysis revealed that the apparent inhibition of HGF signaling was due to a delay in the activation because HGF phosphorylated MAPK with a peak at 5-7 min in cells treated with thiol antioxidants.	Sulfhydryl Compounds	195-200	hepatocyte growth factor	Homo sapiens	126-129
11761336-7	2001	Thus, in cardiac myocytes, thiol antioxidants delay HGF-mediated MAPK activation and suppress subsequent signaling eventsvia reactive oxygen species-independent mechanism.	Sulfhydryl Compounds	27-32	hepatocyte growth factor	Homo sapiens	52-55
11563864-5	2001	The thiol oxidation and superoxide anion release were inhibited by diphenyliodonium, a NADPH oxidase and NOsynthase inhibitor, proving that the respiratory burst and the NOsynthase were involved in the oxidation processes occurring in the differentiated THP-1.	Sulfhydryl Compounds	4-9	GLI family zinc finger 2	Homo sapiens	254-259
11768235-9	2001	Addition of thiol donors abrogated the PAO-mediated induction of HO-1 in a dose dependent fashion.	Sulfhydryl Compounds	12-17	heme oxygenase 1	Homo sapiens	65-69
12552810-4	2001	Some properties of the enzyme such as the sensitivity to thiol reagent and the effects of metal ions, for instance inhibited by Zn2+ and activited by Mn2+, Mg2+ are identical to dihydropyrimidinase.	Sulfhydryl Compounds	57-62	dihydropyrimidinase	Homo sapiens	178-197
11577346-3	2001	Because of its variety of reaction partners (DNA, proteins, low-molecular weight thiols, prosthetic groups, reactive oxygen intermediates), its widespread production (by three different NO synthases (NOS) and the fact that its activity is strongly influenced by its concentration, NO continues to surprise and perplex immunologists.	Sulfhydryl Compounds	81-87	nitric oxide synthase 2	Homo sapiens	186-198
11518677-5	2001	The two novel observations reported here are that 1) cotreatment of cells with NCX-456, but not mesalamine, resulted in concentration-dependent protection against death factor-induced apoptosis and inhibition of caspase activity, and 2) exposure to dithiothreitol, an agent that effectively removes NO from thiol groups, resulted in a 70% recovery of caspase activity, which is consistent with S-nitrosation as a major mechanism for caspase inactivation.	Sulfhydryl Compounds	307-312	T cell leukemia homeobox 2	Homo sapiens	79-82
11551525-7	2001	Pretreatment with the thiol compounds and hyperoxia totally inhibited H(2)O(2)-induced NF-kappaB binding and cell injury as measured by LDH release.	Sulfhydryl Compounds	22-27	nuclear factor kappa B subunit 1	Homo sapiens	87-96
11438521-8	2001	PBN-induced neurite outgrowth and ERK activation were counteracted by the thiol-based antioxidant N-acetylcysteine.	Sulfhydryl Compounds	74-79	Eph receptor B1	Rattus norvegicus	34-37
11509657-9	2001	Our data provide evidence for molecular mechanisms of redox signal sensing through the thiol-disulfide redox cycle coupled with the thioredoxin system in the Yap1p NES.	Sulfhydryl Compounds	87-92	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	158-163
11443071-7	2001	This effect appeared related to oxidation of eNOS thiols as it was completely reversed by dithiothreitol.	Sulfhydryl Compounds	50-56	nitric oxide synthase 3	Homo sapiens	45-49
11532983-8	2001	Biochemical data suggest that FAA causes ERK activation through a thiol-regulated and tyrosine kinase-dependent, but growth factor receptor- and protein kinase C-independent pathway.	Sulfhydryl Compounds	66-71	fumarylacetoacetate hydrolase	Homo sapiens	30-33
11532983-8	2001	Biochemical data suggest that FAA causes ERK activation through a thiol-regulated and tyrosine kinase-dependent, but growth factor receptor- and protein kinase C-independent pathway.	Sulfhydryl Compounds	66-71	mitogen-activated protein kinase 1	Homo sapiens	41-44
11532983-11	2001	Together these results confirm and extend the previously reported genetic instability occurring in cells from HT1 patients and allow us to speculate that this tumorigenic-related phenomenon may rely on the biochemical/cellular effects of FAA as a thiol-reacting and organelle/mitotic spindle-disturbing agent.	Sulfhydryl Compounds	247-252	fumarylacetoacetate hydrolase	Homo sapiens	238-241
11554454-11	2001	Data suggest (a) each HRM can contribute to HO-2-heme interaction, (b) heme iron interacts with cysteine thiol, (c) charged residues upstream of Cys264-Pro265 result in its high-affinity heme binding, and (d) inhibition of HO-2 activity by synthetic metalloporphyrins does not involve HRMs.	Sulfhydryl Compounds	105-110	heme oxygenase 2	Homo sapiens	44-48
11592410-2	2001	Different classes of MMP inhibitors, including hydroxamic acids, phosphinic acids and thiols, have been previously described.	Sulfhydryl Compounds	86-92	matrix metallopeptidase 2	Homo sapiens	21-24
11470753-2	2001	In this report we demonstrate that, in addition to cPKCalpha, six other PKC isozymes that are representative of the three subfamilies within the PKC family (cPKCbeta1, cPKCbeta2 and cPKCgamma, nPKCdelta and nPKCepsilon and aPKC-zeta) are subject to inactivation by S-glutathiolation induced by the thiol-specific oxidant diamide, which induces disulfide bridge formation.	Sulfhydryl Compounds	272-277	protein kinase C delta	Homo sapiens	157-218
11470753-6	2001	The results provide evidence that at least some pro-oxidant environments may support the potent inactivation of nPKCepsilon and other PKC isozymes implicated in tumor promotion/progression by the mechanisms of S-glutathiolation and, in some cases, disulfide bridge formation among the isozyme thiols, without inducing substantial nPKCdelta inactivation.	Sulfhydryl Compounds	293-299	protein kinase C delta	Homo sapiens	113-116
11390385-9	2001	hCyP-A supported antioxidant activity of Prx II and Prx VI both against thiol (dithiothreitol)-containing metal-catalyzed oxidation (MCO) systems and ascorbate-containing MCO systems.	Sulfhydryl Compounds	72-77	peptidylprolyl isomerase A	Homo sapiens	0-6
11390385-9	2001	hCyP-A supported antioxidant activity of Prx II and Prx VI both against thiol (dithiothreitol)-containing metal-catalyzed oxidation (MCO) systems and ascorbate-containing MCO systems.	Sulfhydryl Compounds	72-77	peroxiredoxin 2	Homo sapiens	41-47
11470753-2	2001	In this report we demonstrate that, in addition to cPKCalpha, six other PKC isozymes that are representative of the three subfamilies within the PKC family (cPKCbeta1, cPKCbeta2 and cPKCgamma, nPKCdelta and nPKCepsilon and aPKC-zeta) are subject to inactivation by S-glutathiolation induced by the thiol-specific oxidant diamide, which induces disulfide bridge formation.	Sulfhydryl Compounds	272-277	protein kinase C delta	Homo sapiens	72-75
11551744-7	2001	Preconditioning induction of stress proteins (i.e., hemeoxygenase-1 and neuronal nitric oxide synthase) and hypothermia therapy suppress the generation of toxic reactive oxygen, lipid, and thiol species evoked by bioactive iron complexes in the brain.	Sulfhydryl Compounds	189-194	heme oxygenase 1	Homo sapiens	52-67
11694050-8	2001	These results are consistent with a mechanism in which the free thiols of heat-treated beta-lg or BSA catalyse the formation of a range of monomers, dimers and higher polymers of alpha-la.	Sulfhydryl Compounds	64-70	beta-lactoglobulin	Bos taurus	87-94
11694050-8	2001	These results are consistent with a mechanism in which the free thiols of heat-treated beta-lg or BSA catalyse the formation of a range of monomers, dimers and higher polymers of alpha-la.	Sulfhydryl Compounds	64-70	lactalbumin alpha	Bos taurus	179-187
11466611-7	2001	However, all these agents induced ANT to undergo thiol oxidation/derivatization.	Sulfhydryl Compounds	49-54	solute carrier family 25 member 6	Homo sapiens	34-37
11448159-6	2001	Both oxidase inhibitors and the thiol antioxidant N-acetyl cysteine decreased Tat-induced JNK1 activation in parallel with reduction in oxidant levels.	Sulfhydryl Compounds	32-37	tyrosine aminotransferase	Homo sapiens	78-81
11530836-1	2001	Glutaredoxin is an important enzyme in thiol homeostasis.	Sulfhydryl Compounds	39-44	glutaredoxin	Rattus norvegicus	0-12
11448159-6	2001	Both oxidase inhibitors and the thiol antioxidant N-acetyl cysteine decreased Tat-induced JNK1 activation in parallel with reduction in oxidant levels.	Sulfhydryl Compounds	32-37	mitogen-activated protein kinase 8	Homo sapiens	90-94
11454704-5	2001	Enhancement of intracellular soluble thiol pools after incubation with N-acetylcysteine (2.5 mM), from 3.27 +/- 0.27 nM/mg protein to 5.34 +/- 0.52 nM/mg protein in cells incubated with N-acetylcysteine 30 min before and assessed 4 h after irradiation, abolished the radiation-induced up-regulation of PAI-1.	Sulfhydryl Compounds	37-42	serpin family E member 1	Rattus norvegicus	302-307
11397160-5	2001	Aromatic thiols may be particularly efficacious as their thiol pK(a) values and reactivities match those of the in vivo catalyst, protein disulfide isomerase (PDI).	Sulfhydryl Compounds	9-14	prolyl 4-hydroxylase subunit beta	Homo sapiens	130-157
11425338-6	2001	The ACE activity in the detergent extracts and the purified fractions was inhibited significantly by 10 micromol captopril l(-1), a specific ACE inhibitor, and was restored to 88% of normal activity by the addition of the thiol-alkylating agent N-ethylmaleimide (0.5 mmol l(-1)) in the detergent extracts and the purified fractions incubated with captopril.	Sulfhydryl Compounds	222-227	angiotensin I converting enzyme	Canis lupus familiaris	4-7
11425338-6	2001	The ACE activity in the detergent extracts and the purified fractions was inhibited significantly by 10 micromol captopril l(-1), a specific ACE inhibitor, and was restored to 88% of normal activity by the addition of the thiol-alkylating agent N-ethylmaleimide (0.5 mmol l(-1)) in the detergent extracts and the purified fractions incubated with captopril.	Sulfhydryl Compounds	222-227	angiotensin I converting enzyme	Canis lupus familiaris	141-144
11437639-9	2001	The inhibition of p50-DNA binding by Hg(2+) was reversible in a dose-related manner in vitro by competitive thiols DTT, GSH, and l-cysteine in binding reactions.	Sulfhydryl Compounds	108-114	nuclear factor kappa B subunit 1	Homo sapiens	18-21
11795589-2	2001	Thioredoxin is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- and constitutes a major thiol reducing system, the thioredoxin system.	Sulfhydryl Compounds	52-57	thioredoxin	Homo sapiens	0-11
11795589-2	2001	Thioredoxin is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys- and constitutes a major thiol reducing system, the thioredoxin system.	Sulfhydryl Compounds	52-57	thioredoxin	Homo sapiens	146-157
11468473-5	2001	The TORC assay uses thiol-labeled arachidonic acid as substrate from which free thiols are released by reductive amino acids and the specific activity of phospholipase A2.	Sulfhydryl Compounds	80-86	phospholipase A2 group IB	Homo sapiens	154-170
11433346-7	2001	The prevention of protein oxidation by FANCC reveals a novel mechanism of enzyme regulation during apoptosis and has implications for the treatment of degenerative diseases with thiol reducing agents.	Sulfhydryl Compounds	178-183	FA complementation group C	Homo sapiens	39-44
11413189-5	2001	Incubation of purified TSP-1 with vWF resulted in formation of thiol-dependent complexes of TSP-1 and vWF, generation of new thiols in vWF, and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	63-68	thrombospondin 1	Homo sapiens	23-28
11413189-5	2001	Incubation of purified TSP-1 with vWF resulted in formation of thiol-dependent complexes of TSP-1 and vWF, generation of new thiols in vWF, and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	63-68	von Willebrand factor	Homo sapiens	34-37
11413189-5	2001	Incubation of purified TSP-1 with vWF resulted in formation of thiol-dependent complexes of TSP-1 and vWF, generation of new thiols in vWF, and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	63-68	thrombospondin 1	Homo sapiens	92-97
11413189-5	2001	Incubation of purified TSP-1 with vWF resulted in formation of thiol-dependent complexes of TSP-1 and vWF, generation of new thiols in vWF, and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	63-68	von Willebrand factor	Homo sapiens	102-105
11413189-5	2001	Incubation of purified TSP-1 with vWF resulted in formation of thiol-dependent complexes of TSP-1 and vWF, generation of new thiols in vWF, and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	63-68	von Willebrand factor	Homo sapiens	102-105
11413189-5	2001	Incubation of purified TSP-1 with vWF resulted in formation of thiol-dependent complexes of TSP-1 and vWF, generation of new thiols in vWF, and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	63-68	von Willebrand factor	Homo sapiens	102-105
11413189-5	2001	Incubation of purified TSP-1 with vWF resulted in formation of thiol-dependent complexes of TSP-1 and vWF, generation of new thiols in vWF, and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	125-131	thrombospondin 1	Homo sapiens	23-28
11413189-5	2001	Incubation of purified TSP-1 with vWF resulted in formation of thiol-dependent complexes of TSP-1 and vWF, generation of new thiols in vWF, and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	125-131	von Willebrand factor	Homo sapiens	34-37
11397160-10	2001	The ability of these thiols to reduce (unfold) the protein insulin correlates strongly with their ability to reduce 2-PDE.	Sulfhydryl Compounds	21-27	aldehyde dehydrogenase 7 family member A1	Homo sapiens	118-121
11397160-5	2001	Aromatic thiols may be particularly efficacious as their thiol pK(a) values and reactivities match those of the in vivo catalyst, protein disulfide isomerase (PDI).	Sulfhydryl Compounds	9-14	prolyl 4-hydroxylase subunit beta	Homo sapiens	159-162
11397160-8	2001	The reactivities of aromatic and aliphatic thiols with 2-pyridyldithioethanol (2-PDE), a small molecule disulfide, were determined.	Sulfhydryl Compounds	43-49	aldehyde dehydrogenase 7 family member A1	Homo sapiens	81-84
11384840-7	2001	The free radical scavenging thiol antioxidant N-acetylcysteine (NAC) alleviated partially JNK-1 activation in amino acid-deprived cells.	Sulfhydryl Compounds	28-33	mitogen-activated protein kinase 8	Homo sapiens	90-95
11410278-1	2001	The decameric human erythrocyte protein torin is identical to the thiol-specific antioxidant protein-II (TSA-II), also termed peroxiredoxin-II (Prx-II).	Sulfhydryl Compounds	66-71	peroxiredoxin 2	Homo sapiens	40-45
11410278-1	2001	The decameric human erythrocyte protein torin is identical to the thiol-specific antioxidant protein-II (TSA-II), also termed peroxiredoxin-II (Prx-II).	Sulfhydryl Compounds	66-71	peroxiredoxin 2	Homo sapiens	126-142
11410278-1	2001	The decameric human erythrocyte protein torin is identical to the thiol-specific antioxidant protein-II (TSA-II), also termed peroxiredoxin-II (Prx-II).	Sulfhydryl Compounds	66-71	peroxiredoxin 2	Homo sapiens	144-150
11397717-8	2001	Protecting the free thiol groups of LCAT with 5,5"-dithio-bis-(2-nitrobenzoic acid) before exposure to HOCl-modified LDL, which inhibits lipid hydroperoxide-mediated inactivation of LCAT, failed to prevent the loss of enzyme activity.	Sulfhydryl Compounds	20-25	lecithin-cholesterol acyltransferase	Homo sapiens	36-40
11397717-8	2001	Protecting the free thiol groups of LCAT with 5,5"-dithio-bis-(2-nitrobenzoic acid) before exposure to HOCl-modified LDL, which inhibits lipid hydroperoxide-mediated inactivation of LCAT, failed to prevent the loss of enzyme activity.	Sulfhydryl Compounds	20-25	lecithin-cholesterol acyltransferase	Homo sapiens	182-186
11368786-6	2001	The significance of these findings is discussed with reference to the potential role of PDI and thioredoxin reductase in regulating the mitochondrial functions dependent on the thiol-disulphide transition.	Sulfhydryl Compounds	177-182	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	88-91
11368786-6	2001	The significance of these findings is discussed with reference to the potential role of PDI and thioredoxin reductase in regulating the mitochondrial functions dependent on the thiol-disulphide transition.	Sulfhydryl Compounds	177-182	peroxiredoxin 5	Rattus norvegicus	96-117
11506896-5	2001	The GSNO-stimulated induction of VEGF mRNA was slightly attenuated by MAP protein kinase inhibitors PD98058 and SB203580, but was completely blocked in cells incubated with GSNO in the presence of catalase and superoxide dismutase, enzymes scavenging reactive oxygen species (ROS), or in the presence of thiol-containing antioxidants, N-acetyl cysteine and reduced glutathione.	Sulfhydryl Compounds	304-309	vascular endothelial growth factor A	Homo sapiens	33-37
11506896-5	2001	The GSNO-stimulated induction of VEGF mRNA was slightly attenuated by MAP protein kinase inhibitors PD98058 and SB203580, but was completely blocked in cells incubated with GSNO in the presence of catalase and superoxide dismutase, enzymes scavenging reactive oxygen species (ROS), or in the presence of thiol-containing antioxidants, N-acetyl cysteine and reduced glutathione.	Sulfhydryl Compounds	304-309	catalase	Homo sapiens	197-205
11506896-6	2001	These results suggest that in articular chondrocytes the GSNO-induced VEGF gene transcriptional activation is dependent on endogenous ROS production and oxidative thiol modifications.	Sulfhydryl Compounds	163-168	vascular endothelial growth factor A	Homo sapiens	70-74
11258959-1	2001	An important aspect of the catalytic mechanism of microsomal glutathione transferase (MGST1) is the activation of the thiol of bound glutathione (GSH).	Sulfhydryl Compounds	118-123	microsomal glutathione S-transferase 1	Homo sapiens	86-91
11480417-7	2001	Recently, we have demonstrated that the sensitivity of Ehrlich ascites tumor (EAT) cells to TNF depends on their glutathione (GSH, the most prevalent nonprotein thiol in mammalian cells) content and their rate of proliferation.	Sulfhydryl Compounds	161-166	tumor necrosis factor	Mus musculus	92-95
11678605-3	2001	Zinc finger 3 of transcription factor IIIA (Zn-F3) of Xenopus laevis was investigated as a potential redox active site of reaction of Cr (VI) and thiol compounds.	Sulfhydryl Compounds	146-151	zinc finger protein 3	Bos taurus	44-49
11297517-2	2001	To investigate the molecular mechanism of MIF action, we have used the yeast two-hybrid system and identified PAG, a thiol-specific antioxidant protein, as an interacting partner of MIF.	Sulfhydryl Compounds	117-122	macrophage migration inhibitory factor	Homo sapiens	42-45
11297517-2	2001	To investigate the molecular mechanism of MIF action, we have used the yeast two-hybrid system and identified PAG, a thiol-specific antioxidant protein, as an interacting partner of MIF.	Sulfhydryl Compounds	117-122	macrophage migration inhibitory factor	Homo sapiens	182-185
11344081-2	2001	Using freshly isolated thymocytes from Atm-/- mice that were under stress during postnatal differentiation, we noted that thiol redox activity, as indicated by reduction of the tetrazolium MTS, and DNA turnover activity, as indicated by incorporation of [(3)H]thymidine into DNA, were both greatly increased compared with activities in thymocytes from Atm+/+ mice.	Sulfhydryl Compounds	122-127	ataxia telangiectasia mutated	Mus musculus	39-42
11344081-9	2001	ATM may suppress abnormal DNA turnover and the resultant oncogenesis by regulating cellular thiol redox pathways.	Sulfhydryl Compounds	92-97	ataxia telangiectasia mutated	Mus musculus	0-3
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	Sulfhydryl Compounds	226-231	gastrin releasing peptide	Homo sapiens	65-67
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	Sulfhydryl Compounds	226-231	interferon induced transmembrane protein 1	Homo sapiens	89-95
11350598-2	2001	During a study aimed at generating a bispecific molecule between BN antagonist (D-Trp(6),Leu(13)-psi[CH(2)NH]-Phe(14))BN(6-14) (Antag1) and mAb22 (anti-FcgammaRI), we attempted to cross-link the two molecules by introducing a thiol group into Antag1 via 2-iminothiolane (2-IT, Traut"s reagent).	Sulfhydryl Compounds	226-231	gastrin releasing peptide	Homo sapiens	118-120
11350598-7	2001	Thiol 1a is stable at acidic pH, but is unstable at pH 7.8, cyclizes and loses NH3 to give N-TP1-2-iminothiolane (3a), ES-MS (m/z) [602.1 (M+H)(+)], as well as regenerating TP1.	Sulfhydryl Compounds	0-5	transition protein 1	Homo sapiens	93-96
11350598-7	2001	Thiol 1a is stable at acidic pH, but is unstable at pH 7.8, cyclizes and loses NH3 to give N-TP1-2-iminothiolane (3a), ES-MS (m/z) [602.1 (M+H)(+)], as well as regenerating TP1.	Sulfhydryl Compounds	0-5	transition protein 1	Homo sapiens	173-176
12035543-2	2001	Glutathione-S-transferase (GSTase) and glutathionereductase (GSSG-Rase) activities of cytosol and concentration of thiobarbituric acid reacting compounds (TBA-reactants) and reduced low-molecular weight thiols (rLMW thiols) were used as phenotype parameters.	Sulfhydryl Compounds	203-209	glutathione S-transferase kappa 1	Homo sapiens	0-25
12035543-2	2001	Glutathione-S-transferase (GSTase) and glutathionereductase (GSSG-Rase) activities of cytosol and concentration of thiobarbituric acid reacting compounds (TBA-reactants) and reduced low-molecular weight thiols (rLMW thiols) were used as phenotype parameters.	Sulfhydryl Compounds	203-209	glutathione S-transferase kappa 1	Homo sapiens	27-33
12035543-2	2001	Glutathione-S-transferase (GSTase) and glutathionereductase (GSSG-Rase) activities of cytosol and concentration of thiobarbituric acid reacting compounds (TBA-reactants) and reduced low-molecular weight thiols (rLMW thiols) were used as phenotype parameters.	Sulfhydryl Compounds	216-222	glutathione S-transferase kappa 1	Homo sapiens	0-25
12035543-2	2001	Glutathione-S-transferase (GSTase) and glutathionereductase (GSSG-Rase) activities of cytosol and concentration of thiobarbituric acid reacting compounds (TBA-reactants) and reduced low-molecular weight thiols (rLMW thiols) were used as phenotype parameters.	Sulfhydryl Compounds	216-222	glutathione S-transferase kappa 1	Homo sapiens	27-33
11311209-13	2001	These MAPK stimulations were found to be cellular thiol status-dependent events as NAC reversed these stimulations.	Sulfhydryl Compounds	50-55	mitogen-activated protein kinase 1	Mus musculus	6-10
11256959-2	2001	In this study, purified H-ras was modified by thiol oxidants such as hydrogen peroxide (H(2)O(2)), S-nitrosoglutathione, diamide, glutathione disulphide (GSSG) and cystamine, producing as many as four charge-isomeric forms of the protein.	Sulfhydryl Compounds	46-51	Harvey rat sarcoma virus oncogene	Mus musculus	24-29
11256959-10	2001	These results suggest that H-ras can be S-glutathiolated on multiple thiols in vivo and that at least one of these thiols is normally lipid-modified.	Sulfhydryl Compounds	69-75	Harvey rat sarcoma virus oncogene	Mus musculus	27-32
11256959-10	2001	These results suggest that H-ras can be S-glutathiolated on multiple thiols in vivo and that at least one of these thiols is normally lipid-modified.	Sulfhydryl Compounds	115-121	Harvey rat sarcoma virus oncogene	Mus musculus	27-32
11274078-1	2001	PURPOSE: To study how the expression of thioltransferase (TTase), a critical thiol repair and dethiolating enzyme, is regulated in human lens epithelial cells under oxidative stress.	Sulfhydryl Compounds	40-45	glutaredoxin	Homo sapiens	58-63
11259623-5	2001	N-acetyl-L-cysteine (NAC), a thiol antioxidant, inhibited the apoptosis in DU145 cells after 12 h exposure to beta-lapachone.	Sulfhydryl Compounds	29-34	X-linked Kx blood group	Homo sapiens	21-24
11118431-1	2001	The environmentally sensitive, sulfhydryl-reactive, fluorescent probe N,N"-dimethyl-N-(iodoacetyl)-N"-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) ethylene-diamine (IANBD) was used as a molecular reporter of agonist-induced conformational changes in the beta(2) adrenergic receptor, a prototype hormone-activated G protein-coupled receptor.	Sulfhydryl Compounds	31-41	adrenoceptor beta 2	Homo sapiens	245-272
11368511-4	2001	It was stimulated by the sulfhydryl compounds or EDTA and inhibited by both cysteine proteinase inhibitors and a cathepsin B-specific inhibitor, l-3-trans-(propyl-carbamoyl)oxirane-2-carbonyl)-L-isoleucyl-L-prolin (CA-074).	Sulfhydryl Compounds	25-45	cathepsin B	Bombyx mori	113-124
11278999-2	2001	Nearly half of the 101 cysteines per RyR1 subunit are kept in a reduced (free thiol) state under conditions comparable with resting muscle.	Sulfhydryl Compounds	78-83	ryanodine receptor 1	Homo sapiens	37-41
11278999-4	2001	Oxidation of approximately 10 RyR1 thiols (from approximately 48 to approximately 38 thiols/RyR1 subunit) had little effect on channel activity.	Sulfhydryl Compounds	35-41	ryanodine receptor 1	Homo sapiens	30-34
11278999-4	2001	Oxidation of approximately 10 RyR1 thiols (from approximately 48 to approximately 38 thiols/RyR1 subunit) had little effect on channel activity.	Sulfhydryl Compounds	35-41	ryanodine receptor 1	Homo sapiens	92-96
11278999-7	2001	The results identify at least three functional classes of RyR1 thiols and suggest that 1) the channel may be protected from oxidation by a large reservoir of functionally inert thiols, 2) the channel may be designed to respond to moderate oxidative stress by a change in activation setpoint, and 3) the channel is susceptible to oxidative injury under more extensive conditions.	Sulfhydryl Compounds	63-69	ryanodine receptor 1	Homo sapiens	58-62
11278999-7	2001	The results identify at least three functional classes of RyR1 thiols and suggest that 1) the channel may be protected from oxidation by a large reservoir of functionally inert thiols, 2) the channel may be designed to respond to moderate oxidative stress by a change in activation setpoint, and 3) the channel is susceptible to oxidative injury under more extensive conditions.	Sulfhydryl Compounds	177-183	ryanodine receptor 1	Homo sapiens	58-62
11279063-2	2001	Because verapamil is the most potent stimulator of P-gp ATPase activity, we synthesized a thiol-reactive analog of verapamil (MTS-verapamil) and used it with cysteine-scanning mutagenesis to identify the reactive residues within the drug-binding domain of P-gp.	Sulfhydryl Compounds	90-95	ATP binding cassette subfamily B member 1	Homo sapiens	51-55
11279063-2	2001	Because verapamil is the most potent stimulator of P-gp ATPase activity, we synthesized a thiol-reactive analog of verapamil (MTS-verapamil) and used it with cysteine-scanning mutagenesis to identify the reactive residues within the drug-binding domain of P-gp.	Sulfhydryl Compounds	90-95	ATP binding cassette subfamily B member 1	Homo sapiens	256-260
11380598-1	2001	BACKGROUND: N-acetyl-L-cysteine, a thiol compound, has been shown to potentiate the inhibition of platelet aggregation exerted by organic nitrates and to increase the anti-aggregating effect of L-arginine, which promotes endogenous synthesis of nitric oxide (NO) acting as substrate of platelet constitutive nitric oxide synthase (NOS).	Sulfhydryl Compounds	35-40	nitric oxide synthase 2	Homo sapiens	308-329
11343247-10	2001	Thiol depletion could cause oxidative stress that requires several hours to increase p53; the latter induces Bax, which translocates to mitochondria after Fas stimulation.	Sulfhydryl Compounds	0-5	transformation related protein 53, pseudogene	Mus musculus	85-88
11343247-10	2001	Thiol depletion could cause oxidative stress that requires several hours to increase p53; the latter induces Bax, which translocates to mitochondria after Fas stimulation.	Sulfhydryl Compounds	0-5	BCL2-associated X protein	Mus musculus	109-112
11278616-3	2001	Posttranslational modification of the protein, for example through thiol oxidation or proteolysis, has been shown to be important in converting XDH to XO.	Sulfhydryl Compounds	67-72	xanthine dehydrogenase	Homo sapiens	144-147
11334342-7	2001	The ThioGlo method is compared to our previous method in which N-(1-pyrenyl)maleimide (NPM) is used to derivatize thiol-containing compounds.	Sulfhydryl Compounds	114-119	nucleophosmin 1	Homo sapiens	87-90
11118458-2	2001	Under denaturing conditions (urea, guanidine hydrochloride, guanidine thiocyanate, organic solvent or elevated temperature) and in the presence of thiol initiator, alpha-LA denatures by shuffling its four native disulfide bonds and converts to a mixture of fully oxidized scrambled structures.	Sulfhydryl Compounds	147-152	lactalbumin alpha	Homo sapiens	164-172
11266655-1	2001	The susceptibility of recombinant human thiopurine methyltransferase (hTPMT) to thiol-disulfide exchange was investigated.	Sulfhydryl Compounds	80-85	thiopurine S-methyltransferase	Homo sapiens	70-75
11266655-4	2001	Activity measurements of the enzyme over time in these buffers at 30 degrees C indicated that thiol-disulfide exchange may be a part of the posttranslational modulation of hTPMT activity.	Sulfhydryl Compounds	94-99	thiopurine S-methyltransferase	Homo sapiens	172-177
11266655-9	2001	Inspection of the model indicated that one of the protein thiols subject to slow thiol-disulfide exchange may be situated at the binding site of the co-substrate of the enzyme and thus be responsible for the glutathione/glutathione disulfide modulation of the activity of hTPMT.	Sulfhydryl Compounds	58-64	thiopurine S-methyltransferase	Homo sapiens	272-277
11266655-9	2001	Inspection of the model indicated that one of the protein thiols subject to slow thiol-disulfide exchange may be situated at the binding site of the co-substrate of the enzyme and thus be responsible for the glutathione/glutathione disulfide modulation of the activity of hTPMT.	Sulfhydryl Compounds	58-63	thiopurine S-methyltransferase	Homo sapiens	272-277
11207678-7	2001	Mercaptoethanol and dithiotreitol, two thiol-reducing agents, also efficiently protected ACE activity.	Sulfhydryl Compounds	39-44	angiotensin I converting enzyme	Homo sapiens	89-92
11238660-0	2001	Effect of redox modulation on xenogeneic target cells: the combination of nitric oxide and thiol deprivation protects porcine endothelial cells from lysis by IL-2-activated human NK cells.	Sulfhydryl Compounds	91-96	interleukin 2	Homo sapiens	158-162
11238660-7	2001	It is known that NF-kappa B activation is required for transcription of E-selectin, and the current data show that the suppression of E-selectin expression by S-nitroso-N-acetyl-penicillamine pretreatment and thiol deprivation was associated with reduced NF-kappa B DNA-binding activity in PAEC.	Sulfhydryl Compounds	209-214	nuclear factor kappa B subunit 1	Homo sapiens	17-27
11238660-7	2001	It is known that NF-kappa B activation is required for transcription of E-selectin, and the current data show that the suppression of E-selectin expression by S-nitroso-N-acetyl-penicillamine pretreatment and thiol deprivation was associated with reduced NF-kappa B DNA-binding activity in PAEC.	Sulfhydryl Compounds	209-214	selectin E	Homo sapiens	72-82
11238660-7	2001	It is known that NF-kappa B activation is required for transcription of E-selectin, and the current data show that the suppression of E-selectin expression by S-nitroso-N-acetyl-penicillamine pretreatment and thiol deprivation was associated with reduced NF-kappa B DNA-binding activity in PAEC.	Sulfhydryl Compounds	209-214	selectin E	Homo sapiens	134-144
11238660-7	2001	It is known that NF-kappa B activation is required for transcription of E-selectin, and the current data show that the suppression of E-selectin expression by S-nitroso-N-acetyl-penicillamine pretreatment and thiol deprivation was associated with reduced NF-kappa B DNA-binding activity in PAEC.	Sulfhydryl Compounds	209-214	nuclear factor kappa B subunit 1	Homo sapiens	255-265
12369901-0	2001	Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase and caspase-3 by nitric oxide.	Sulfhydryl Compounds	8-13	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	30-70
11298119-0	2001	Thiols decrease cytokine levels and down-regulate the expression of CD30 on human allergen-specific T helper (Th) 0 and Th2 cells.	Sulfhydryl Compounds	0-6	TNF receptor superfamily member 8	Homo sapiens	68-72
11298119-1	2001	The thiol antioxidant N-acetyl- L-cysteine (NAC), known as a precursor of glutathione (GSH), is used in AIDS treatment trials, as a chemoprotectant in cancer chemotherapy and in treatment of chronic bronchitis.	Sulfhydryl Compounds	4-9	X-linked Kx blood group	Homo sapiens	44-47
11298119-7	2001	Both thiols caused a dose dependent down-regulation of IL-4, IL-5 and IFN-gamma levels in Th0 and Th2 clones, with the most pronounced decrease of IL-4.	Sulfhydryl Compounds	5-11	interleukin 4	Homo sapiens	55-59
11298119-7	2001	Both thiols caused a dose dependent down-regulation of IL-4, IL-5 and IFN-gamma levels in Th0 and Th2 clones, with the most pronounced decrease of IL-4.	Sulfhydryl Compounds	5-11	interleukin 5	Homo sapiens	61-65
11298119-7	2001	Both thiols caused a dose dependent down-regulation of IL-4, IL-5 and IFN-gamma levels in Th0 and Th2 clones, with the most pronounced decrease of IL-4.	Sulfhydryl Compounds	5-11	interferon gamma	Homo sapiens	70-79
11298119-7	2001	Both thiols caused a dose dependent down-regulation of IL-4, IL-5 and IFN-gamma levels in Th0 and Th2 clones, with the most pronounced decrease of IL-4.	Sulfhydryl Compounds	5-11	interleukin 4	Homo sapiens	147-151
12369901-0	2001	Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase and caspase-3 by nitric oxide.	Sulfhydryl Compounds	8-13	caspase 3	Homo sapiens	75-84
12369901-5	2001	Here, we summarize current knowledge on active site thiol modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and caspase-3 by nitric oxide.	Sulfhydryl Compounds	52-57	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	74-114
12369901-5	2001	Here, we summarize current knowledge on active site thiol modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and caspase-3 by nitric oxide.	Sulfhydryl Compounds	52-57	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	116-121
12369901-5	2001	Here, we summarize current knowledge on active site thiol modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and caspase-3 by nitric oxide.	Sulfhydryl Compounds	52-57	caspase 3	Homo sapiens	127-136
11182524-1	2001	Thioredoxin (Trx) plays important biological roles both intra- and extracellularly via thiol redox control.	Sulfhydryl Compounds	87-92	thioredoxin	Homo sapiens	0-11
11182524-1	2001	Thioredoxin (Trx) plays important biological roles both intra- and extracellularly via thiol redox control.	Sulfhydryl Compounds	87-92	thioredoxin	Homo sapiens	13-16
11222536-13	2001	Its gene product showed the characteristics which support our speculation that TTase may play a major role in maintaining the homeostasis of lens protein thiols thus protecting against oxidative stress.	Sulfhydryl Compounds	154-160	glutaredoxin	Homo sapiens	79-84
11222498-8	2001	The enhancement of IL-4 gene expression by HgCl2 was significantly reduced by antioxidants (both sulphydryl and non-sulphydryl containing).	Sulfhydryl Compounds	97-107	interleukin 4	Rattus norvegicus	19-23
11222498-8	2001	The enhancement of IL-4 gene expression by HgCl2 was significantly reduced by antioxidants (both sulphydryl and non-sulphydryl containing).	Sulfhydryl Compounds	116-126	interleukin 4	Rattus norvegicus	19-23
11288819-3	2001	RESULTS: The thiol protein of 33 kDa apparent molecular weight (p33) identified by the loss of labelling with biotin maleimide was identified as tropomyosin due to its retarded running in 6 mol/l urea gels and immunoblotting.	Sulfhydryl Compounds	13-18	inhibitor of growth family member 1	Homo sapiens	64-67
11288819-6	2001	CONCLUSIONS: NEM reaction with p33 requires two thiols.	Sulfhydryl Compounds	48-54	inhibitor of growth family member 1	Homo sapiens	31-34
11288819-7	2001	Only the cytoskeletal form of tropomyosin from the TM3 gene has more than one thiol group and agrees with SDS-PAGE mobility.	Sulfhydryl Compounds	78-83	tropomyosin 3	Homo sapiens	51-54
11165196-1	2001	The atherogenic lipoprotein Lp(a) consists of an LDL-like core and apo(a), linked to apoB via a thiol bridge.	Sulfhydryl Compounds	96-101	lipoprotein(a)	Homo sapiens	16-33
11181056-0	2001	Activation of heat shock factor 1 by pyrrolidine dithiocarbamate is mediated by its activities as pro-oxidant and thiol modulator.	Sulfhydryl Compounds	114-119	heat shock transcription factor 1	Homo sapiens	14-33
11181056-6	2001	In addition, PDTC-induced activation of HSF1 was significantly inhibited by NAC and a thiol-reducing agent dithiothreitol (DTT), while it was partially prevented by other antioxidants, AA, BHT, and PG.	Sulfhydryl Compounds	86-91	heat shock transcription factor 1	Homo sapiens	40-44
11181056-7	2001	These results suggest that the activation of HSF1 by PDTC may be due to its activities as pro-oxidant and thiol group modulator rather than anti-oxidant.	Sulfhydryl Compounds	106-111	heat shock transcription factor 1	Homo sapiens	45-49
11327828-4	2001	Its activity in vitro can be inhibited by S-nitrosylation of a critical thiol in the DNA-interacting p50 subunit, but modulation of NF-kappaB activity by nitric oxide synthase (NOS) has been attributed to other mechanisms.	Sulfhydryl Compounds	72-77	nuclear factor kappa B subunit 1	Homo sapiens	101-104
11233600-3	2001	This aggregation depended on the presence of reduced sulfhydryl residues on IP-10, on the amount of loaded protein, and on the concentration of the ammonium persulfate used to polymerize the stacking gel.	Sulfhydryl Compounds	53-63	C-X-C motif chemokine ligand 10	Homo sapiens	76-81
11341985-3	2001	Similarly, the thiol-reducing agents N-(2-mercaptoethyl)-1,3-diaminopropane and dithiothreitol strongly activated both JNK and p38 MAPK in cells undergoing HS.	Sulfhydryl Compounds	15-20	mitogen-activated protein kinase 8	Rattus norvegicus	119-122
11341985-5	2001	Thiol-reducing agents prevented AP-1 DNA binding induced by HS.	Sulfhydryl Compounds	0-5	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-36
11171069-2	2001	Transport activities of both GalP and GLUT1 are inhibited by the thiol-group-specific reagent, N-ethylmaleimide.	Sulfhydryl Compounds	65-70	solute carrier family 2 member 1	Homo sapiens	38-43
11165196-1	2001	The atherogenic lipoprotein Lp(a) consists of an LDL-like core and apo(a), linked to apoB via a thiol bridge.	Sulfhydryl Compounds	96-101	apolipoprotein B	Homo sapiens	85-89
11264891-7	2001	The stabilization of the cellular thiol status was followed by an improvement of phagocytosis and the degree of maturation as well as significant changes in the synthesis of IL-6 and IL-1ra.	Sulfhydryl Compounds	34-39	interleukin 6	Homo sapiens	174-178
11165879-1	2001	Human Serum Albumin (HSA) exerted a significant lipid peroxidase activity with the use of a thiol-reducing equivalent such as dithiothreitol (DTT).	Sulfhydryl Compounds	92-97	albumin	Homo sapiens	6-19
11264891-7	2001	The stabilization of the cellular thiol status was followed by an improvement of phagocytosis and the degree of maturation as well as significant changes in the synthesis of IL-6 and IL-1ra.	Sulfhydryl Compounds	34-39	interleukin 1 receptor antagonist	Homo sapiens	183-189
11460925-1	2001	Oxidative damage of mammalian mitochondria induced by Ca2+ and prooxidants is mediated by the attack of mitochondria-generated reactive oxygen species on membrane protein thiols promoting oxidation and cross-linkage that leads to the opening of the mitochondrial permeability transition pore (Castilho et al., 1995).	Sulfhydryl Compounds	171-177	carbonic anhydrase 2	Homo sapiens	54-57
11171373-7	2001	Overexpression of Bcl2 suppressed an increase in oxidized glutathione content and thiol precursor content.	Sulfhydryl Compounds	82-87	BCL2 apoptosis regulator	Homo sapiens	18-22
11460925-7	2001	Interestingly, the monofunctional thiol reagent mersalyl induces an extensive cyclosporin A-insensitive potato mitochondrial swelling, even in the presence of lower Ca2+ concentrations (&gt;0.01 mM).	Sulfhydryl Compounds	34-39	carbonic anhydrase 2	Homo sapiens	165-168
11306078-0	2001	Modulation of aldose reductase activity through S-thiolation by physiological thiols.	Sulfhydryl Compounds	78-84	aldose reductase	Bos taurus	14-30
11251822-1	2001	In the Gram-positive bacterium, Streptomyces coelicolor A3(2), expression of the thioredoxin system is modulated by a sigma factor called sigmaR in response to changes in the cytoplasmic thiol-disulphide status, and the activity of sigmaR is controlled post-translationally by an anti-sigma factor, RsrA.	Sulfhydryl Compounds	187-192	thioredoxin	Homo sapiens	81-92
11251822-7	2001	On the basis of these data, we propose that a thiol-disulphide redox switch is formed between two of C11, C41 and C44, and that all three residues play an essential role in anti-sigma factor activity in their reduced state, perhaps by acting as ligands for zinc.	Sulfhydryl Compounds	46-51	RNA polymerase III subunit K	Homo sapiens	101-104
11170422-5	2001	However, the binding energy of these thiols is decreased 4-6 kcal/mol compared to a peptide derived from the carboxyl terminus of H-Ras.	Sulfhydryl Compounds	37-43	HRas proto-oncogene, GTPase	Homo sapiens	130-135
11156944-10	2001	We presume that the mechanism of TACE activation by H2O2 is due to an oxidative attack of the pro-domain thiol group and disruption of its inhibitory coordination with the Zn++ in the catalytic domain of TACE.	Sulfhydryl Compounds	105-110	ADAM metallopeptidase domain 17	Homo sapiens	33-37
11162401-4	2001	The C-termini of the scFv antibody fragments contain 1-3 cysteine residues that are separated by a hydrophilic linker (GGSSGGSSGS) from the binding domain and are accessible for site-specific functionalization with thiol-reactive reagents.	Sulfhydryl Compounds	215-220	immunglobulin heavy chain variable region	Homo sapiens	21-25
11162537-5	2001	We demonstrate for the first time that wild-type rVWF and rVWFR273W interacted with the thiol-dependent oxidoreductase ERp57 during biosynthesis in the ER.	Sulfhydryl Compounds	88-93	von Willebrand factor	Rattus norvegicus	49-53
11139404-2	2001	In the present study, we have produced recombinant hENT1, rENT1, hENT2 and rENT2 in Xenopus oocytes and investigated uridine transport following exposure to the impermeant thiol-reactive reagent p-chloromercuriphenyl sulphonate (PCMBS).	Sulfhydryl Compounds	172-177	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	51-56
11139404-2	2001	In the present study, we have produced recombinant hENT1, rENT1, hENT2 and rENT2 in Xenopus oocytes and investigated uridine transport following exposure to the impermeant thiol-reactive reagent p-chloromercuriphenyl sulphonate (PCMBS).	Sulfhydryl Compounds	172-177	solute carrier family 29 member 2	Homo sapiens	65-70
11170581-3	2001	Free cysteine thiol groups of keratin extracted from chicken feathers were partially carboxymethylated with iodoacetic acid (25-76% cysteine modification).	Sulfhydryl Compounds	14-19	keratin	Gallus gallus	30-37
11022039-6	2001	As assessed by these properties, H(4)B binding was not rapid and required the presence of a reduced thiol.	Sulfhydryl Compounds	100-105	H4 clustered histone 4	Homo sapiens	33-38
11527217-1	2001	Rabbit muscle creatine kinase (CK) was modified by 5,5"-dithio-bis(2-nitrobenzoic acid) accompanied by 3 M guanidine hydrochloride denaturation to produce a partially folded state with modified thiol groups.	Sulfhydryl Compounds	194-199	creatine kinase M-type	Oryctolagus cuniculus	7-29
11920245-5	2001	RESULTS: Normal values were found for superoxide dismutase, methemoglobin, trolox equivalent antioxidant capacity and total plasma thiols in CDA1 patients.	Sulfhydryl Compounds	131-137	codanin 1	Homo sapiens	141-145
11146114-1	2000	Thioltransferase (glutaredoxin) is a member of the family of thiol-disulfide oxido-reductases that maintain the sulfhydryl homeostasis in cells by catalyzing thiol-disulfide interchange reactions.	Sulfhydryl Compounds	112-122	glutaredoxin	Homo sapiens	0-16
11123355-3	2001	The reduction-oxidation (redox) state of the cell is primarily a consequence of the precise balance between the levels of ROS and endogenous thiol buffers present in the cell, such as glutathione and thioredoxin, which protect cells from oxidative damage.	Sulfhydryl Compounds	141-146	thioredoxin	Homo sapiens	200-211
12040418-0	2001	Unfolding of Recombinant Single-chain Insulin in Denaturants Containing Thiol Reagents.	Sulfhydryl Compounds	72-77	insulin	Homo sapiens	38-45
12040418-2	2001	In the presence of denaturants and thiol reagents, the native structure of PIP was disturbed and its native disulfides were shuffled to form a mixture of scrambled isomers which have different degrees of unfolding.	Sulfhydryl Compounds	35-40	prolactin induced protein	Homo sapiens	75-78
11223752-0	2001	Regional variations in thiol distribution pattern and superoxide dismutase activity of the male reproductive tract of the rat modulate the transport of spermatozoa through the epididymis and vas deferens.	Sulfhydryl Compounds	23-28	arginine vasopressin	Rattus norvegicus	191-194
11223752-4	2001	The vas deferens showed a higher level of superoxide dismutase activity and a low profile of thiol exposure.	Sulfhydryl Compounds	93-98	arginine vasopressin	Rattus norvegicus	4-7
11223752-5	2001	CONCLUSION: We conclude that the strong scavenging potential and the lesser thiol exposure of the vas create an apparently inert vas lumen which facilitates the transit of spermatozoa through the vas.	Sulfhydryl Compounds	76-81	arginine vasopressin	Rattus norvegicus	98-101
11223752-5	2001	CONCLUSION: We conclude that the strong scavenging potential and the lesser thiol exposure of the vas create an apparently inert vas lumen which facilitates the transit of spermatozoa through the vas.	Sulfhydryl Compounds	76-81	arginine vasopressin	Rattus norvegicus	129-132
11223752-5	2001	CONCLUSION: We conclude that the strong scavenging potential and the lesser thiol exposure of the vas create an apparently inert vas lumen which facilitates the transit of spermatozoa through the vas.	Sulfhydryl Compounds	76-81	arginine vasopressin	Rattus norvegicus	129-132
11697031-0	2001	Preparation of Fab" from murine IgG2a for thiol reactive conjugation.	Sulfhydryl Compounds	42-47	FA complementation group B	Homo sapiens	15-18
11212221-7	2001	Thimerosal, a thiol reagent which sensitizes the inositol 1,4,5-trisphosphate (IP3) receptor, inhibited the spermine-induced increase in PA(Man) and, to a lesser extent, that of Jw.	Sulfhydryl Compounds	14-19	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-92
11134546-6	2001	However, as demonstrated in immuno-coprecipitation experiments, the kinetics of NF-kappaB DNA binding is strictly paralleled by decreased and increased complex formation between NF-kappaB and thioredoxin (Trx), the reducing catalyst of Cys-62 of NF-kappaB subunit p50, the reduced thiol function of which is essential for efficient NF-kappaB DNA binding.	Sulfhydryl Compounds	281-286	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-89
11134546-6	2001	However, as demonstrated in immuno-coprecipitation experiments, the kinetics of NF-kappaB DNA binding is strictly paralleled by decreased and increased complex formation between NF-kappaB and thioredoxin (Trx), the reducing catalyst of Cys-62 of NF-kappaB subunit p50, the reduced thiol function of which is essential for efficient NF-kappaB DNA binding.	Sulfhydryl Compounds	281-286	thioredoxin 1	Mus musculus	192-203
11134546-6	2001	However, as demonstrated in immuno-coprecipitation experiments, the kinetics of NF-kappaB DNA binding is strictly paralleled by decreased and increased complex formation between NF-kappaB and thioredoxin (Trx), the reducing catalyst of Cys-62 of NF-kappaB subunit p50, the reduced thiol function of which is essential for efficient NF-kappaB DNA binding.	Sulfhydryl Compounds	281-286	thioredoxin 1	Mus musculus	205-208
11146114-1	2000	Thioltransferase (glutaredoxin) is a member of the family of thiol-disulfide oxido-reductases that maintain the sulfhydryl homeostasis in cells by catalyzing thiol-disulfide interchange reactions.	Sulfhydryl Compounds	112-122	glutaredoxin	Homo sapiens	18-30
11146114-2	2000	One of the major consequences of oxidative stress in brain is formation of protein-glutathione mixed disulfide (through oxidation of protein thiols) which can be reversed by thioltransferase during recovery of brain from oxidative stress.	Sulfhydryl Compounds	141-147	glutaredoxin	Homo sapiens	174-190
11146114-8	2000	These discrete neuronal concentrations of thioltransferase would be consistent with an essential role in modulating recovery of protein thiols from mixed disulfides formed during oxidative stress.	Sulfhydryl Compounds	136-142	glutaredoxin	Homo sapiens	42-58
11056008-3	2000	In support of this, we found that Cpd 5 inhibited the activity of thiol containing cellular protein tyrosine phosphatase (PTP) enzyme, with consequent induction of various tyrosine phosphoproteins, but not serine or tyrosine phosphoproteins.	Sulfhydryl Compounds	66-71	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	92-120
11121042-9	2000	Furthermore, a thiol reducing agent, DTT, reversed not only the in vitro inhibition of JNK1 activity by SNAP but also the in vivo suppression of JNK1 activity by IFN-gamma.	Sulfhydryl Compounds	15-20	mitogen-activated protein kinase 8	Mus musculus	87-91
11121042-9	2000	Furthermore, a thiol reducing agent, DTT, reversed not only the in vitro inhibition of JNK1 activity by SNAP but also the in vivo suppression of JNK1 activity by IFN-gamma.	Sulfhydryl Compounds	15-20	mitogen-activated protein kinase 8	Mus musculus	145-149
11121042-9	2000	Furthermore, a thiol reducing agent, DTT, reversed not only the in vitro inhibition of JNK1 activity by SNAP but also the in vivo suppression of JNK1 activity by IFN-gamma.	Sulfhydryl Compounds	15-20	interferon gamma	Mus musculus	162-171
11121042-12	2000	Collectively, our data suggest that endogenous NO mediates the IFN-gamma-induced suppression of JNK1 activation in macrophage cells by means of a thiol-redox mechanism.	Sulfhydryl Compounds	146-151	interferon gamma	Mus musculus	63-72
11121042-12	2000	Collectively, our data suggest that endogenous NO mediates the IFN-gamma-induced suppression of JNK1 activation in macrophage cells by means of a thiol-redox mechanism.	Sulfhydryl Compounds	146-151	mitogen-activated protein kinase 8	Mus musculus	96-100
11137340-1	2000	The objective of the present study was to establish several methods for the introduction of thiol groups onto the surface of human serum albumin (HSA) nanoparticles.	Sulfhydryl Compounds	92-97	albumin	Homo sapiens	131-144
11276306-1	2000	The effects of HIV antigen glycoproteins gp160, gp41, and gp36 on thiol-dependent specific (affinity) binding of serum IgM, IgG, and IgA with the corresponding antigens were determined by the formation of signal thiol-containing analytes (free nonprotein SH groups).	Sulfhydryl Compounds	66-71	glutamyl aminopeptidase	Homo sapiens	41-46
11276306-1	2000	The effects of HIV antigen glycoproteins gp160, gp41, and gp36 on thiol-dependent specific (affinity) binding of serum IgM, IgG, and IgA with the corresponding antigens were determined by the formation of signal thiol-containing analytes (free nonprotein SH groups).	Sulfhydryl Compounds	66-71	podoplanin	Homo sapiens	58-62
11276306-1	2000	The effects of HIV antigen glycoproteins gp160, gp41, and gp36 on thiol-dependent specific (affinity) binding of serum IgM, IgG, and IgA with the corresponding antigens were determined by the formation of signal thiol-containing analytes (free nonprotein SH groups).	Sulfhydryl Compounds	212-217	podoplanin	Homo sapiens	58-62
11276306-3	2000	The results suggest that the thiol-selective mechanism underlies in vitro conjugation of HIV antigen glycoproteins gp160, gp41, and gp36 with serum immunoglobulins.	Sulfhydryl Compounds	29-34	glutamyl aminopeptidase	Homo sapiens	115-120
11276306-3	2000	The results suggest that the thiol-selective mechanism underlies in vitro conjugation of HIV antigen glycoproteins gp160, gp41, and gp36 with serum immunoglobulins.	Sulfhydryl Compounds	29-34	podoplanin	Homo sapiens	132-136
11177571-1	2000	Thimet oligopeptidase (TOP) is a thiol-dependent metallopeptidase, which can cleave and thereby modulate the activity of many neuropeptides.	Sulfhydryl Compounds	33-38	thimet oligopeptidase 1	Rattus norvegicus	0-21
11177571-1	2000	Thimet oligopeptidase (TOP) is a thiol-dependent metallopeptidase, which can cleave and thereby modulate the activity of many neuropeptides.	Sulfhydryl Compounds	33-38	thimet oligopeptidase 1	Rattus norvegicus	23-26
11145066-1	2000	Zofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor, endowed also with a marked cardioprotective activity.	Sulfhydryl Compounds	91-101	angiotensin I converting enzyme	Homo sapiens	137-166
11145066-1	2000	Zofenopril is a pro-drug designed to undergo metabolic hydrolysis yielding the active free sulfhydryl compound zofenoprilat, which is an angiotensin converting enzyme (ACE) inhibitor, endowed also with a marked cardioprotective activity.	Sulfhydryl Compounds	91-101	angiotensin I converting enzyme	Homo sapiens	168-171
11175251-7	2000	Pore formation by ANT is induced by a variety of different agents (e.g. Ca(2+), atractyloside, thiol oxidation, the pro-apoptotic HIV-1 protein Vpr, etc.)	Sulfhydryl Compounds	95-100	solute carrier family 25 member 6	Homo sapiens	18-21
11214354-10	2000	VE-DEF animals had significantly higher (p &lt; 0.05) levels of myocardial lipid peroxidation and lower (p &lt; 0.05) protein thiols following I-R compared to the CON animals.	Sulfhydryl Compounds	126-132	UTP25 small subunit processome component	Rattus norvegicus	3-6
11056008-3	2000	In support of this, we found that Cpd 5 inhibited the activity of thiol containing cellular protein tyrosine phosphatase (PTP) enzyme, with consequent induction of various tyrosine phosphoproteins, but not serine or tyrosine phosphoproteins.	Sulfhydryl Compounds	66-71	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	122-125
11087425-2	2000	Specific labeling with the thiol-reactive fluorescence probe, 6-acryloyl-2-dimethylaminonaphthalene (acrylodan), was used to study the structural organization and dynamic properties of the extreme regions of human apolipoprotein A-I (apoA-I) in lipid-free and lipid-bound states.	Sulfhydryl Compounds	27-32	apolipoprotein A1	Homo sapiens	214-232
11093754-2	2000	Thiol groups in HIF-1 or in proteins that modify HIF-1 are conventional targets for regulation by nitric oxide (NO).	Sulfhydryl Compounds	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
11093754-2	2000	Thiol groups in HIF-1 or in proteins that modify HIF-1 are conventional targets for regulation by nitric oxide (NO).	Sulfhydryl Compounds	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-54
11087425-2	2000	Specific labeling with the thiol-reactive fluorescence probe, 6-acryloyl-2-dimethylaminonaphthalene (acrylodan), was used to study the structural organization and dynamic properties of the extreme regions of human apolipoprotein A-I (apoA-I) in lipid-free and lipid-bound states.	Sulfhydryl Compounds	27-32	apolipoprotein A1	Homo sapiens	234-240
11132156-7	2000	Affinity chromatography demonstrated that little chimpanzee CR1a bound to human C3i linked to activated thiol-Sepharose (C3i-ATS), while over 50% of both chimpanzee CR1-like and chimpanzee E-CR bound to C3i-ATS.	Sulfhydryl Compounds	104-109	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	60-63
11153595-3	2000	It was hypothesized that lipopolysaccharide (LPS)-induced IL-1beta secretion may be modulated by the intracellular thiol redox status of the cells.	Sulfhydryl Compounds	115-120	interleukin 1 beta	Homo sapiens	58-66
10998414-6	2000	Hyperreactive sulfhydryls previously shown to reside within the RyR1 complex (Liu, G., and Pessah, I. N. (1994) J. Biol.	Sulfhydryl Compounds	14-25	ryanodine receptor 1	Homo sapiens	64-68
11137456-6	2000	These results suggest that PE is a metallo endopeptidase that contains a thiol group important for it"s activity.	Sulfhydryl Compounds	73-78	prolyl endopeptidase	Homo sapiens	27-29
11098855-2	2000	MATERIALS AND METHODS: We used mutant cells null for glucose 6 phosphate dehydrogenase (G6PD) activity since reducing equivalents, required for reduction of oxidized thiols, are typically generated through G6PD regulated production of NADPH.	Sulfhydryl Compounds	166-172	glucose-6-phosphate dehydrogenase	Homo sapiens	53-86
11071366-0	2000	Oxidative inactivation of brain ecto-5"-nucleotidase by thiols/Fe2+ system.	Sulfhydryl Compounds	56-62	5'-nucleotidase	Bos taurus	32-52
11098855-2	2000	MATERIALS AND METHODS: We used mutant cells null for glucose 6 phosphate dehydrogenase (G6PD) activity since reducing equivalents, required for reduction of oxidized thiols, are typically generated through G6PD regulated production of NADPH.	Sulfhydryl Compounds	166-172	glucose-6-phosphate dehydrogenase	Homo sapiens	88-92
11098855-2	2000	MATERIALS AND METHODS: We used mutant cells null for glucose 6 phosphate dehydrogenase (G6PD) activity since reducing equivalents, required for reduction of oxidized thiols, are typically generated through G6PD regulated production of NADPH.	Sulfhydryl Compounds	166-172	glucose-6-phosphate dehydrogenase	Homo sapiens	206-210
11098855-12	2000	Moreover, when the G6PD deficient cells were transfected with the gene encoding wild-type G6PD (A1A), they recovered close to wild-type cellular thiol status, cell survival and DSB rejoining.	Sulfhydryl Compounds	145-150	glucose-6-phosphate dehydrogenase	Homo sapiens	19-23
11132637-2	2000	The mammalian enzymes exist originally as the dehydrogenase form (XDH) but can be converted to the oxidase form (XO) either reversibly by oxidation of sulfhydryl residues of the protein molecule or irreversibly by proteolysis.	Sulfhydryl Compounds	151-161	xanthine dehydrogenase	Homo sapiens	66-69
11080313-2	2000	The thiol tripeptides glutathione (GSH) and homoglutathione (hGSH) are very abundant in legume root nodules and their synthesis is catalyzed by the enzymes gamma-glutamylcysteine synthetase (gammaECS), GSH synthetase (GSHS), and hGSH synthetase (hGSHS).	Sulfhydryl Compounds	4-9	glutamate-cysteine ligase catalytic subunit	Homo sapiens	156-189
11080313-2	2000	The thiol tripeptides glutathione (GSH) and homoglutathione (hGSH) are very abundant in legume root nodules and their synthesis is catalyzed by the enzymes gamma-glutamylcysteine synthetase (gammaECS), GSH synthetase (GSHS), and hGSH synthetase (hGSHS).	Sulfhydryl Compounds	4-9	glutathione synthetase	Homo sapiens	202-216
11032908-6	2000	A selective inhibitor of cyclooxygenase-2, SC 58125, prevented depletion of ascorbate and thiols, the two major water-soluble antioxidants in traumatized brain.	Sulfhydryl Compounds	90-96	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	25-41
11080313-2	2000	The thiol tripeptides glutathione (GSH) and homoglutathione (hGSH) are very abundant in legume root nodules and their synthesis is catalyzed by the enzymes gamma-glutamylcysteine synthetase (gammaECS), GSH synthetase (GSHS), and hGSH synthetase (hGSHS).	Sulfhydryl Compounds	4-9	glutathione synthetase	Homo sapiens	218-222
11071366-10	2000	Overall, thiols, expressing more inhibitory effect on the activity of 5"-nucleotidase, were found to be more effective in potentiating the Fe2+-mediated inactivation.	Sulfhydryl Compounds	9-15	5'-nucleotidase	Bos taurus	70-85
11080313-2	2000	The thiol tripeptides glutathione (GSH) and homoglutathione (hGSH) are very abundant in legume root nodules and their synthesis is catalyzed by the enzymes gamma-glutamylcysteine synthetase (gammaECS), GSH synthetase (GSHS), and hGSH synthetase (hGSHS).	Sulfhydryl Compounds	4-9	glutathione synthetase	Homo sapiens	229-244
11080313-2	2000	The thiol tripeptides glutathione (GSH) and homoglutathione (hGSH) are very abundant in legume root nodules and their synthesis is catalyzed by the enzymes gamma-glutamylcysteine synthetase (gammaECS), GSH synthetase (GSHS), and hGSH synthetase (hGSHS).	Sulfhydryl Compounds	4-9	glutathione synthetase	Homo sapiens	246-251
11071366-11	2000	Further, kinetic analyses indicate that Fe2+ and thiols inhibit the 5"-nucleotidase in a competitive or uncompetitive manner, respectively.	Sulfhydryl Compounds	49-55	5'-nucleotidase	Bos taurus	68-83
11071366-12	2000	These results suggest that ecto-5"-nucleotidase from brain membrane is one of proteins susceptible to thiols/Fe2+-catalyzed oxidation, and the oxidative inactivation may be related to the selective association of Fe2+ and thiols to the enzyme molecule.	Sulfhydryl Compounds	102-108	5'-nucleotidase	Bos taurus	27-47
11071366-12	2000	These results suggest that ecto-5"-nucleotidase from brain membrane is one of proteins susceptible to thiols/Fe2+-catalyzed oxidation, and the oxidative inactivation may be related to the selective association of Fe2+ and thiols to the enzyme molecule.	Sulfhydryl Compounds	222-228	5'-nucleotidase	Bos taurus	27-47
11041860-6	2000	Reactivity of cysteine residues to 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB) indicated that wild-type RPA contained 8.2 reactive thiols/molecule including all four cysteines in the zinc-finger motif.	Sulfhydryl Compounds	130-136	replication protein A1	Homo sapiens	103-106
10807919-6	2000	It is concluded that the dependence of AtPCS1 on the provision of heavy metal ions for activity in media containing glutathione and other thiol peptides is a reflection of this enzyme"s requirement for glutathione-like peptides containing blocked thiol groups for activity.	Sulfhydryl Compounds	138-143	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	39-45
11058767-1	2000	Lipocalin-type prostaglandin (PG) D synthase (PGDS) catalyzes the isomerization of PGH(2), a common precursor of various prostanoids, to produce PGD(2), a potent endogenous somnogen and nociceptive modulator, in the presence of sulfhydryl compounds.	Sulfhydryl Compounds	228-248	prostaglandin D2 synthase	Homo sapiens	46-50
11058767-7	2000	X-ray crystallographic analyses revealed that PGDS possesses a beta-barrel structure with a hydrophobic pocket in which an active thiol, Cys(65), the active center for the catalytic reaction, was located facing to the inside of the pocket.	Sulfhydryl Compounds	130-135	prostaglandin D2 synthase	Homo sapiens	46-50
10807919-6	2000	It is concluded that the dependence of AtPCS1 on the provision of heavy metal ions for activity in media containing glutathione and other thiol peptides is a reflection of this enzyme"s requirement for glutathione-like peptides containing blocked thiol groups for activity.	Sulfhydryl Compounds	247-252	Eukaryotic aspartyl protease family protein	Arabidopsis thaliana	39-45
11009473-8	2000	Protection and increased ROS signals with flumazenil (10 microM) were abolished with the thiol reductant N-(2-mercaptopropionyl)-glycine (2-MPG, 800 microM), an antioxidant (cell death: 2-MPG + flumazenil, 55 +/- 12%, n = 6; ROS signals: 2-MPG + flumazenil, 0.11 +/- 0.19, n = 6).	Sulfhydryl Compounds	89-94	N-methylpurine DNA glycosylase	Gallus gallus	140-143
11009473-8	2000	Protection and increased ROS signals with flumazenil (10 microM) were abolished with the thiol reductant N-(2-mercaptopropionyl)-glycine (2-MPG, 800 microM), an antioxidant (cell death: 2-MPG + flumazenil, 55 +/- 12%, n = 6; ROS signals: 2-MPG + flumazenil, 0.11 +/- 0.19, n = 6).	Sulfhydryl Compounds	89-94	N-methylpurine DNA glycosylase	Gallus gallus	188-191
11009473-8	2000	Protection and increased ROS signals with flumazenil (10 microM) were abolished with the thiol reductant N-(2-mercaptopropionyl)-glycine (2-MPG, 800 microM), an antioxidant (cell death: 2-MPG + flumazenil, 55 +/- 12%, n = 6; ROS signals: 2-MPG + flumazenil, 0.11 +/- 0.19, n = 6).	Sulfhydryl Compounds	89-94	N-methylpurine DNA glycosylase	Gallus gallus	188-191
11023973-4	2000	This mode of regulation may serve as a paradigm for redox-sensing by eukaryotic transcription factors as most-including NF-kappaB, AP-1, and p53-contain reactive thiols in their DNA binding regions, the modification of which alters binding in vitro.	Sulfhydryl Compounds	162-168	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	131-135
11051096-14	2000	The results suggest that functionally critical thiol groups may be associated with PtdIns 4-kinase and PtdIns 4-P 5-kinase and that changes of their redox state by ROS can impair their activities, which may be an important factor in the oxidant-induced cardiac dysfunction.	Sulfhydryl Compounds	47-52	phosphatidylinositol-5-phosphate 4-kinase type 2 beta	Homo sapiens	103-122
11023973-4	2000	This mode of regulation may serve as a paradigm for redox-sensing by eukaryotic transcription factors as most-including NF-kappaB, AP-1, and p53-contain reactive thiols in their DNA binding regions, the modification of which alters binding in vitro.	Sulfhydryl Compounds	162-168	tumor protein p53	Homo sapiens	141-144
10947965-2	2000	Similarly, chemical modification of the thiol residues present in both reduced and Zn(2+)-depleted trimer converts TRAIL into an inactive dimer.	Sulfhydryl Compounds	40-45	TNF superfamily member 10	Homo sapiens	115-120
10998306-2	2000	Mica substrates, derivatized with a monolayer of amine or thiol-terminated silanes, were used to immobilize the particles.	Sulfhydryl Compounds	58-63	MHC class I polypeptide-related sequence A	Homo sapiens	0-4
11059866-2	2000	Thioredoxin (TRX) is a stress-inducible thiol-containing protein.	Sulfhydryl Compounds	40-45	thioredoxin	Homo sapiens	0-11
11059866-2	2000	Thioredoxin (TRX) is a stress-inducible thiol-containing protein.	Sulfhydryl Compounds	40-45	thioredoxin	Homo sapiens	13-16
11005854-1	2000	Mammalian xanthine oxidoreductases, which catalyze the last two steps in the formation of urate, are synthesized as the dehydrogenase form xanthine dehydrogenase (XDH) but can be readily converted to the oxidase form xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis.	Sulfhydryl Compounds	255-265	xanthine dehydrogenase	Bos taurus	139-161
11005854-1	2000	Mammalian xanthine oxidoreductases, which catalyze the last two steps in the formation of urate, are synthesized as the dehydrogenase form xanthine dehydrogenase (XDH) but can be readily converted to the oxidase form xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis.	Sulfhydryl Compounds	255-265	xanthine dehydrogenase	Bos taurus	163-166
10993916-5	2000	Experiments with a thiol antioxidant (N-acetylcysteine) in vivo and nitric oxide (NO) donors in vitro confirmed that reactive oxygen species were required for p53 activation.	Sulfhydryl Compounds	19-24	transformation related protein 53, pseudogene	Mus musculus	159-162
10987444-0	2000	Design and synthesis of potent thiol-based inhibitors of endothelin converting enzyme-1.	Sulfhydryl Compounds	31-36	endothelin converting enzyme 1	Rattus norvegicus	57-87
11011142-9	2000	Conversely, replacing Ser-80 and Phe-201 in Rt6.2 with cysteines, as in Rt6.1, converted the thiol-independent Rt6.2 NADase to a thiol-dependent enzyme.	Sulfhydryl Compounds	93-98	ADP-ribosyltransferase 2a	Mus musculus	44-47
11011142-9	2000	Conversely, replacing Ser-80 and Phe-201 in Rt6.2 with cysteines, as in Rt6.1, converted the thiol-independent Rt6.2 NADase to a thiol-dependent enzyme.	Sulfhydryl Compounds	93-98	ADP-ribosyltransferase 2a	Mus musculus	72-75
11011142-9	2000	Conversely, replacing Ser-80 and Phe-201 in Rt6.2 with cysteines, as in Rt6.1, converted the thiol-independent Rt6.2 NADase to a thiol-dependent enzyme.	Sulfhydryl Compounds	93-98	ADP-ribosyltransferase 2a	Mus musculus	72-75
11011142-9	2000	Conversely, replacing Ser-80 and Phe-201 in Rt6.2 with cysteines, as in Rt6.1, converted the thiol-independent Rt6.2 NADase to a thiol-dependent enzyme.	Sulfhydryl Compounds	129-134	ADP-ribosyltransferase 2a	Mus musculus	44-47
11011142-9	2000	Conversely, replacing Ser-80 and Phe-201 in Rt6.2 with cysteines, as in Rt6.1, converted the thiol-independent Rt6.2 NADase to a thiol-dependent enzyme.	Sulfhydryl Compounds	129-134	ADP-ribosyltransferase 2a	Mus musculus	72-75
11011142-9	2000	Conversely, replacing Ser-80 and Phe-201 in Rt6.2 with cysteines, as in Rt6.1, converted the thiol-independent Rt6.2 NADase to a thiol-dependent enzyme.	Sulfhydryl Compounds	129-134	ADP-ribosyltransferase 2a	Mus musculus	72-75
11011142-12	2000	From these observations, we conclude that t!he Rt6.1 antigen has thiol-dependent NADase activity, and that Cys-80 and Cys-201 confer thiol sensitivity to Rt6.1 NADase.	Sulfhydryl Compounds	65-70	ADP-ribosyltransferase 2a	Mus musculus	47-50
11011142-12	2000	From these observations, we conclude that t!he Rt6.1 antigen has thiol-dependent NADase activity, and that Cys-80 and Cys-201 confer thiol sensitivity to Rt6.1 NADase.	Sulfhydryl Compounds	133-138	ADP-ribosyltransferase 2b	Rattus norvegicus	154-157
10961904-8	2000	Circulating erythrocytes from the GSHPx-1-deficient mice exhibited a slight reduction in membrane thiols, indicating that high exposure to peroxides might occur naturally in the circulation.	Sulfhydryl Compounds	98-104	glutathione peroxidase 1	Mus musculus	34-41
11465080-2	2000	The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.	Sulfhydryl Compounds	276-282	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	4-31
10976000-2	2000	The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets.	Sulfhydryl Compounds	4-9	interleukin 1 beta	Rattus norvegicus	135-144
11465080-2	2000	The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.	Sulfhydryl Compounds	276-282	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	33-36
10982384-5	2000	Cys352 and Cys355 are required to maintain the fully oxidized redox state of Ero1p, and also play an auxiliary role in thiol-disulfide exchange with Pdi1p.	Sulfhydryl Compounds	119-124	ER oxidoreductin	Saccharomyces cerevisiae S288C	77-82
10965882-7	2000	In this regard, H2O2 and a membrane permeable thiol-oxidizing agent, diamide, stimulated protein tyrosine phosphorylation of p120 and p70, and ERK activation in VSMCs.	Sulfhydryl Compounds	46-51	catenin delta 1	Homo sapiens	125-129
10965882-7	2000	In this regard, H2O2 and a membrane permeable thiol-oxidizing agent, diamide, stimulated protein tyrosine phosphorylation of p120 and p70, and ERK activation in VSMCs.	Sulfhydryl Compounds	46-51	annexin A6	Homo sapiens	134-137
10965882-7	2000	In this regard, H2O2 and a membrane permeable thiol-oxidizing agent, diamide, stimulated protein tyrosine phosphorylation of p120 and p70, and ERK activation in VSMCs.	Sulfhydryl Compounds	46-51	mitogen-activated protein kinase 1	Homo sapiens	143-146
10971592-3	2000	The thiouredopyrene-3,6,8-trisulfonate-labeled cytochrome c was prepared by incubating the thiol reactive form of the dye with yeast iso-1-cytochrome c, containing a single cysteine residue.	Sulfhydryl Compounds	91-96	LOC104968582	Bos taurus	47-59
10982384-5	2000	Cys352 and Cys355 are required to maintain the fully oxidized redox state of Ero1p, and also play an auxiliary role in thiol-disulfide exchange with Pdi1p.	Sulfhydryl Compounds	119-124	protein disulfide isomerase PDI1	Saccharomyces cerevisiae S288C	149-154
10982384-6	2000	These results suggest a model for the function of Ero1p wherein Cys100 and Cys105 form a redox-active disulfide bond that engages directly in thiol-disulfide exchange with ER oxidoreductases.	Sulfhydryl Compounds	142-147	ER oxidoreductin	Saccharomyces cerevisiae S288C	50-55
10956045-6	2000	The heme Soret peak of ferric cystathionine beta-synthase is at 428 nm and shifts to approximately 395 nm upon addition of the thiol chelator, mercuric chloride.	Sulfhydryl Compounds	127-132	cystathionine beta-synthase	Homo sapiens	30-57
10996515-6	2000	Thioredoxin reductase is an antioxidant enzyme having an important regulatory task of thiol redox status and intracellular signaling processes coupled with the glutathione system.	Sulfhydryl Compounds	86-91	peroxiredoxin 5	Homo sapiens	0-21
11019979-7	2000	Reduction in vWF multimer size was associated with formation of new thiols in vWF and there was no evidence for additional proteolytic processing of vWF.	Sulfhydryl Compounds	68-74	von Willebrand factor	Homo sapiens	13-16
11019979-7	2000	Reduction in vWF multimer size was associated with formation of new thiols in vWF and there was no evidence for additional proteolytic processing of vWF.	Sulfhydryl Compounds	68-74	von Willebrand factor	Homo sapiens	78-81
11019979-7	2000	Reduction in vWF multimer size was associated with formation of new thiols in vWF and there was no evidence for additional proteolytic processing of vWF.	Sulfhydryl Compounds	68-74	von Willebrand factor	Homo sapiens	78-81
11019979-10	2000	In support of this hypothesis, incubation of vWF with the protein reductants, protein disulfide isomerase and thioredoxin, resulted in formation of new thiols in vWF and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	152-158	von Willebrand factor	Homo sapiens	45-48
11019979-10	2000	In support of this hypothesis, incubation of vWF with the protein reductants, protein disulfide isomerase and thioredoxin, resulted in formation of new thiols in vWF and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	152-158	thioredoxin	Homo sapiens	110-121
11019979-10	2000	In support of this hypothesis, incubation of vWF with the protein reductants, protein disulfide isomerase and thioredoxin, resulted in formation of new thiols in vWF and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	152-158	von Willebrand factor	Homo sapiens	162-165
11019979-10	2000	In support of this hypothesis, incubation of vWF with the protein reductants, protein disulfide isomerase and thioredoxin, resulted in formation of new thiols in vWF and reduction in the average multimer size of vWF.	Sulfhydryl Compounds	152-158	von Willebrand factor	Homo sapiens	162-165
10956021-5	2000	To directly examine whether PKC could be inactivated by S-glutathiolation, we used the thiol-specific oxidant diamide because its oxidant activity is restricted to induction of disulfide bridge formation.	Sulfhydryl Compounds	63-68	protein kinase C, gamma	Rattus norvegicus	28-31
10956021-12	2000	Taken together, the results indicate that PKC isozymes can be oxidatively inactivated by S-thiolation reactions involving endogenous thiols such as GSH.	Sulfhydryl Compounds	133-139	protein kinase C, gamma	Rattus norvegicus	42-45
10926847-14	2000	Similar to MCT1, monocarboxylate transport via MCT4 was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid.	Sulfhydryl Compounds	87-92	solute carrier family 16 member 1	Rattus norvegicus	11-15
10966111-3	2000	Here we report that PO2 dynamically controls the redox state of 6-8 out of 50 thiols in each RyR1 subunit and thereby tunes the response to NO.	Sulfhydryl Compounds	78-84	ryanodine receptor 1	Homo sapiens	93-97
10926847-14	2000	Similar to MCT1, monocarboxylate transport via MCT4 was sensitive to inhibition by the thiol reagent p-chloromercuribenzoesulphonic acid.	Sulfhydryl Compounds	87-92	solute carrier family 16 member 3	Rattus norvegicus	47-51
10940389-5	2000	We have demonstrated that ATP, and thiol-modifying agents with ATP, specifically regulate only the TAL part of the TA activities.	Sulfhydryl Compounds	35-40	transaldolase 1	Homo sapiens	99-102
10933886-0	2000	Activation of thiol-dependent antioxidant activity of human serum albumin by alkaline pH is due to the B-like conformational change.	Sulfhydryl Compounds	14-19	albumin	Homo sapiens	60-73
10924354-3	2000	A thiol inhibitor MAG-283 had IC(50) values of 480, 3, 280, 14, 1.1, and 2.3 nM against human interstitial collagenase (MMP-1), gelatinase A (MMP-2), stromelysin (MMP-3), matrilysin (MMP-7), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9), respectively.	Sulfhydryl Compounds	2-7	matrix metallopeptidase 1	Homo sapiens	94-118
10924354-3	2000	A thiol inhibitor MAG-283 had IC(50) values of 480, 3, 280, 14, 1.1, and 2.3 nM against human interstitial collagenase (MMP-1), gelatinase A (MMP-2), stromelysin (MMP-3), matrilysin (MMP-7), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9), respectively.	Sulfhydryl Compounds	2-7	matrix metallopeptidase 1	Homo sapiens	120-125
10924354-3	2000	A thiol inhibitor MAG-283 had IC(50) values of 480, 3, 280, 14, 1.1, and 2.3 nM against human interstitial collagenase (MMP-1), gelatinase A (MMP-2), stromelysin (MMP-3), matrilysin (MMP-7), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9), respectively.	Sulfhydryl Compounds	2-7	matrix metallopeptidase 2	Homo sapiens	142-147
10924354-3	2000	A thiol inhibitor MAG-283 had IC(50) values of 480, 3, 280, 14, 1.1, and 2.3 nM against human interstitial collagenase (MMP-1), gelatinase A (MMP-2), stromelysin (MMP-3), matrilysin (MMP-7), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9), respectively.	Sulfhydryl Compounds	2-7	matrix metallopeptidase 3	Homo sapiens	163-168
10924354-3	2000	A thiol inhibitor MAG-283 had IC(50) values of 480, 3, 280, 14, 1.1, and 2.3 nM against human interstitial collagenase (MMP-1), gelatinase A (MMP-2), stromelysin (MMP-3), matrilysin (MMP-7), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9), respectively.	Sulfhydryl Compounds	2-7	matrix metallopeptidase 7	Homo sapiens	171-181
10924354-3	2000	A thiol inhibitor MAG-283 had IC(50) values of 480, 3, 280, 14, 1.1, and 2.3 nM against human interstitial collagenase (MMP-1), gelatinase A (MMP-2), stromelysin (MMP-3), matrilysin (MMP-7), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9), respectively.	Sulfhydryl Compounds	2-7	matrix metallopeptidase 7	Homo sapiens	183-188
10924354-3	2000	A thiol inhibitor MAG-283 had IC(50) values of 480, 3, 280, 14, 1.1, and 2.3 nM against human interstitial collagenase (MMP-1), gelatinase A (MMP-2), stromelysin (MMP-3), matrilysin (MMP-7), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9), respectively.	Sulfhydryl Compounds	2-7	matrix metallopeptidase 8	Homo sapiens	215-220
10924354-3	2000	A thiol inhibitor MAG-283 had IC(50) values of 480, 3, 280, 14, 1.1, and 2.3 nM against human interstitial collagenase (MMP-1), gelatinase A (MMP-2), stromelysin (MMP-3), matrilysin (MMP-7), neutrophil collagenase (MMP-8), and gelatinase B (MMP-9), respectively.	Sulfhydryl Compounds	2-7	matrix metallopeptidase 9	Homo sapiens	241-246
10900126-8	2000	Ratios of thiols/disulfides (XSH/XSSX) and activities of GR and G-6PDH were also related to a high reducing potential exerted by GSH but not by minor thiols.	Sulfhydryl Compounds	150-156	glutathione-disulfide reductase	Homo sapiens	57-59
11045618-0	2000	Conformation and stability of thiol-modified bovine beta-lactoglobulin.	Sulfhydryl Compounds	30-35	beta-lactoglobulin	Bos taurus	52-70
11045618-2	2000	Beta-lactoglobulin A has a free thiol at Cys121, which is buried between the beta-barrel and the C-terminal major alpha-helix.	Sulfhydryl Compounds	32-37	beta-lactoglobulin	Bos taurus	0-18
11045618-3	2000	This thiol group was specifically reacted with 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB) in the presence of 1.0 M Gdn-HCI at pH 7.5, producing a modified beta-lactoglobulin (TNB-bIg) containing a mixed disulfide bond with 5-thio-2-nitrobenzoic acid (TNB).	Sulfhydryl Compounds	5-10	beta-lactoglobulin	Bos taurus	155-173
10900126-8	2000	Ratios of thiols/disulfides (XSH/XSSX) and activities of GR and G-6PDH were also related to a high reducing potential exerted by GSH but not by minor thiols.	Sulfhydryl Compounds	150-156	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	64-70
11035262-2	2000	Previous studies showed that the loss of cyt c triggered superoxide production by mitochondria and contributed to the oxidation of cellular thiol-disulfide redox state.	Sulfhydryl Compounds	140-145	cytochrome c, somatic	Homo sapiens	41-46
10930424-4	2000	The heterodimer of DsbC with the inactive DsbC carboxymethylated at both active site thiols shows about 50% TPOR activity of DsbC but no isomerase activity, indicating that the DsbC subunit in the heterodimer displays full TPOR activity but little, if any, isomerase activity.	Sulfhydryl Compounds	85-91	putative protein DsbC	Escherichia coli	19-23
10915737-9	2000	In conclusion, CYP3A activates skullcap diterpenoids into reactive metabolites that deplete cellular thiols and increase cell [Ca(2+)].	Sulfhydryl Compounds	101-107	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	15-20
10893182-3	2000	As hydrogen peroxide and other oxidants can affect signal transduction pathways at several levels, the present study was aimed to verify: (i) the occurrence of GGT-dependent production of hydrogen peroxide in melanoma cells; (ii) the effects of GGT-dependent prooxidant reactions on known redox-sensitive cellular targets, i.e. protein thiols, the nuclear transcription factor NF-kappa B and p53.	Sulfhydryl Compounds	336-342	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	160-163
10893182-5	2000	The occurrence of GGT-dependent production of hydrogen peroxide was apparent in 2/60 cells, in which it was accompanied by lower levels of cell surface protein thiols.	Sulfhydryl Compounds	160-166	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	18-21
10893182-9	2000	Taken together, these results indicate that the expression of GGT activity can provide melanoma cells with an additional source of hydrogen peroxide, and that such prooxidant reactions are capable to modify protein thiols at the cell surface level.	Sulfhydryl Compounds	215-221	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	62-65
10944420-7	2000	IFN-gamma increased superoxide and thiol productions in both types of macrophages.	Sulfhydryl Compounds	35-40	interferon gamma	Mus musculus	0-9
10944420-8	2000	We conclude that IFN-gamma promotes macrophage-mediated LDL oxidation by stimulating superoxide and thiol production under conditions where iNOS-catalyzed NO release is restricted.	Sulfhydryl Compounds	100-105	interferon gamma	Mus musculus	17-26
10972187-0	2000	Thermotoga maritima AglA, an extremely thermostable NAD+-, Mn2+-, and thiol-dependent alpha-glucosidase.	Sulfhydryl Compounds	70-75	alpha-glucosidase/alpha-galactosidase	Thermotoga maritima MSB8	86-103
10913246-1	2000	For approximately one-third of estrogen receptor (ER)-positive breast cancer patients, extracted tumor ER is unable to bind to its cognate DNA estrogen response element (ERE), an effect that is partly reversible by the thiol-reducing agent dithiothreitol (DTT).	Sulfhydryl Compounds	219-224	estrogen receptor 1	Homo sapiens	31-48
10913246-1	2000	For approximately one-third of estrogen receptor (ER)-positive breast cancer patients, extracted tumor ER is unable to bind to its cognate DNA estrogen response element (ERE), an effect that is partly reversible by the thiol-reducing agent dithiothreitol (DTT).	Sulfhydryl Compounds	219-224	estrogen receptor 1	Homo sapiens	50-52
10913246-1	2000	For approximately one-third of estrogen receptor (ER)-positive breast cancer patients, extracted tumor ER is unable to bind to its cognate DNA estrogen response element (ERE), an effect that is partly reversible by the thiol-reducing agent dithiothreitol (DTT).	Sulfhydryl Compounds	219-224	estrogen receptor 1	Homo sapiens	103-105
10913246-5	2000	Rapid proteolytic digestion of monomeric, non-DNA-bound ER-DBD followed by HPLC-MS analysis of the resulting peptides demonstrates that zinc inhibits thiol oxidation of the DNA-binding finger, but not the finger supporting the flexible dimerization loop, which remains sensitive to internal disulfide formation.	Sulfhydryl Compounds	150-155	estrogen receptor 1	Homo sapiens	56-58
10913246-6	2000	These findings indicate that the loss of ER DNA-binding function in extracts from some primary breast tumors and in ER or ER-DBD exposed to thiol-reacting oxidants results from this asymmetric zinc finger susceptibility to disulfide formation that prevents dimerization.	Sulfhydryl Compounds	140-145	estrogen receptor 1	Homo sapiens	41-43
10913246-6	2000	These findings indicate that the loss of ER DNA-binding function in extracts from some primary breast tumors and in ER or ER-DBD exposed to thiol-reacting oxidants results from this asymmetric zinc finger susceptibility to disulfide formation that prevents dimerization.	Sulfhydryl Compounds	140-145	estrogen receptor 1	Homo sapiens	116-118
10913246-6	2000	These findings indicate that the loss of ER DNA-binding function in extracts from some primary breast tumors and in ER or ER-DBD exposed to thiol-reacting oxidants results from this asymmetric zinc finger susceptibility to disulfide formation that prevents dimerization.	Sulfhydryl Compounds	140-145	estrogen receptor 1	Homo sapiens	116-118
10930424-4	2000	The heterodimer of DsbC with the inactive DsbC carboxymethylated at both active site thiols shows about 50% TPOR activity of DsbC but no isomerase activity, indicating that the DsbC subunit in the heterodimer displays full TPOR activity but little, if any, isomerase activity.	Sulfhydryl Compounds	85-91	putative protein DsbC	Escherichia coli	42-46
10930424-4	2000	The heterodimer of DsbC with the inactive DsbC carboxymethylated at both active site thiols shows about 50% TPOR activity of DsbC but no isomerase activity, indicating that the DsbC subunit in the heterodimer displays full TPOR activity but little, if any, isomerase activity.	Sulfhydryl Compounds	85-91	putative protein DsbC	Escherichia coli	42-46
10930424-4	2000	The heterodimer of DsbC with the inactive DsbC carboxymethylated at both active site thiols shows about 50% TPOR activity of DsbC but no isomerase activity, indicating that the DsbC subunit in the heterodimer displays full TPOR activity but little, if any, isomerase activity.	Sulfhydryl Compounds	85-91	putative protein DsbC	Escherichia coli	42-46
10880344-7	2000	In summary, the data suggest that, in addition to previously reported phospholipid hydroperoxide glutathione peroxidase (GPx-4), GPx-1 is an efficient inhibitor of 5-LO even at low thiol concentrations, and is involved in the regulation of cellular 5-LO activity in various cell types.	Sulfhydryl Compounds	181-186	glutathione peroxidase 1	Homo sapiens	129-134
10880356-4	2000	Furthermore, we show that c-Jun, p50, glycogen phosphorylase b, glyceraldehyde-3-phosphate dehydrogenase, creatine kinase, glutaredoxin and caspase-3 can be precipitated from a mixture of purified thiol-containing proteins by the formation of a mixed-disulphide bond with GSNO-Sepharose.	Sulfhydryl Compounds	197-202	caspase 3	Homo sapiens	140-149
10880344-1	2000	In contrast to neutrophils or B-lymphocytes, cells of the monocytic lineage like rat macrophages, human peripheral blood monocytes and Mono Mac 6 cells contain a strong inhibitor of 5-lipoxygenase (5-LO) activity, which scavenges hydroperoxides and inhibits 5-LO activity in broken-cell preparations in the absence of exogenously added thiols.	Sulfhydryl Compounds	336-342	arachidonate 5-lipoxygenase	Homo sapiens	182-196
10899304-5	2000	Here we have analyzed the pK(a) values of the active-site thiols in wild type thioredoxin and a 400-fold more oxidizing thioredoxin variant by NMR spectroscopy, using selectively (13)C(beta)-Cys-labeled proteins.	Sulfhydryl Compounds	58-64	thioredoxin	Homo sapiens	78-89
10880356-4	2000	Furthermore, we show that c-Jun, p50, glycogen phosphorylase b, glyceraldehyde-3-phosphate dehydrogenase, creatine kinase, glutaredoxin and caspase-3 can be precipitated from a mixture of purified thiol-containing proteins by the formation of a mixed-disulphide bond with GSNO-Sepharose.	Sulfhydryl Compounds	197-202	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	26-31
10880356-4	2000	Furthermore, we show that c-Jun, p50, glycogen phosphorylase b, glyceraldehyde-3-phosphate dehydrogenase, creatine kinase, glutaredoxin and caspase-3 can be precipitated from a mixture of purified thiol-containing proteins by the formation of a mixed-disulphide bond with GSNO-Sepharose.	Sulfhydryl Compounds	197-202	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	64-104
10976517-9	2000	The fact that p-hydroxymercuribenzoate (PHMB) and iodoacetamide abolished irreversible inhibition of GST upon the action of transacetylase on DAMC strongly characterized transacetylase as a protein containing thiol group at the active site.	Sulfhydryl Compounds	209-214	hematopoietic prostaglandin D synthase	Rattus norvegicus	101-104
10873557-4	2000	However, little is known regarding the ability of iNOS-derived NO to interact with physiological substrates such as thiols to yield biologically active S-nitrosothiols during endotoxemia.	Sulfhydryl Compounds	116-122	nitric oxide synthase 2	Rattus norvegicus	50-54
10826917-4	2000	LADH inactivation by MPO/H2O2/NaCl and by NaOCl was similarly prevented by thiol compounds such as GSH, L-cysteine, N-acetylcysteine, penicillamine and N-(2-mercaptopropionyl-glycine) in agreement with the role of HOCI in LADH inactivation by MPO/H2O2/NaCl.	Sulfhydryl Compounds	75-80	myeloperoxidase	Sus scrofa	21-24
10826917-4	2000	LADH inactivation by MPO/H2O2/NaCl and by NaOCl was similarly prevented by thiol compounds such as GSH, L-cysteine, N-acetylcysteine, penicillamine and N-(2-mercaptopropionyl-glycine) in agreement with the role of HOCI in LADH inactivation by MPO/H2O2/NaCl.	Sulfhydryl Compounds	75-80	myeloperoxidase	Sus scrofa	243-246
10828986-4	2000	We performed equilibrium redox titrations to investigate the thermodynamics of the thiol/disulfide exchange between thioredoxin f and the regulatory sulfhydryl groups of fructose-1,6-bisphosphatase, sedoheptulose-1,7-bisphosphatase, phosphoribulokinase, NADP-glyceraldehyde phosphate dehydrogenase, and the chloroplast ATPsynthase.	Sulfhydryl Compounds	83-88	thioredoxin-like protein CITRX, chloroplastic	Solanum lycopersicum	116-127
10852716-0	2000	Cysteine 981 of the human insulin receptor is required for covalent cross-linking between beta-subunit and a thiol-reactive membrane-associated protein.	Sulfhydryl Compounds	109-114	insulin receptor	Homo sapiens	26-42
10852716-2	2000	In this study, we examined the ability of the bifunctional cross-linking reagent 1,6-bismaleimidohexane (BMH) to covalently link IR with interacting proteins that possess reactive thiols.	Sulfhydryl Compounds	180-186	insulin receptor	Homo sapiens	129-131
10841552-0	2000	Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase.	Sulfhydryl Compounds	0-5	methionine sulfoxide reductase A	Bos taurus	75-105
10841552-7	2000	A reaction mechanism based on the known reactivities of thiols with sulfoxides and the available data for MsrA was formulated.	Sulfhydryl Compounds	56-62	methionine sulfoxide reductase A	Bos taurus	106-110
10841552-10	2000	The active site is returned to the reduced state for another round of catalysis by a series of thiol-disulfide exchange reactions via Cys-227, DTT, or thioredoxin.	Sulfhydryl Compounds	95-100	thioredoxin	Bos taurus	151-162
10827984-1	2000	Past biochemical work on myosin subfragment 1 (S1) has shown that the bent alpha-helix containing the reactive thiols SH1 (Cys(707)) and SH2 (Cys(697)) changes upon nucleotide and actin binding.	Sulfhydryl Compounds	111-117	myosin heavy chain 14	Homo sapiens	25-31
10837337-10	2000	NAC given within the first 3 h posttreatment further delayed cell death and increased the intracellular thiol level in SIN-1 but not.	Sulfhydryl Compounds	104-109	MAPK associated protein 1	Homo sapiens	119-124
10843779-1	2000	The observation that the level of S-thiolated proteins (protein-thiol mixed disulfides) was transiently increased in the lens epithelial cells correlation with the transient inactivation of glyceraldehyde-3-phosphate dehydrogenase (G-3PD), a key glycolytic enzyme, when the cells were treated with a bolus of hydrogen peroxide, prompted our speculation that G-3PD may have been transiently thiolated at the SH sensitive active center.	Sulfhydryl Compounds	36-41	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	190-230
10834943-3	2000	In the present study, ferrocyanide and thiols, which are susceptible to one-electron and two-electron oxidation, respectively, were subjected to a flux of superoxide in the presence and absence of SOD or SOD mimics.	Sulfhydryl Compounds	39-45	superoxide dismutase 1	Homo sapiens	197-200
10834943-3	2000	In the present study, ferrocyanide and thiols, which are susceptible to one-electron and two-electron oxidation, respectively, were subjected to a flux of superoxide in the presence and absence of SOD or SOD mimics.	Sulfhydryl Compounds	39-45	superoxide dismutase 1	Homo sapiens	204-207
10843779-1	2000	The observation that the level of S-thiolated proteins (protein-thiol mixed disulfides) was transiently increased in the lens epithelial cells correlation with the transient inactivation of glyceraldehyde-3-phosphate dehydrogenase (G-3PD), a key glycolytic enzyme, when the cells were treated with a bolus of hydrogen peroxide, prompted our speculation that G-3PD may have been transiently thiolated at the SH sensitive active center.	Sulfhydryl Compounds	36-41	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	232-237
10843779-1	2000	The observation that the level of S-thiolated proteins (protein-thiol mixed disulfides) was transiently increased in the lens epithelial cells correlation with the transient inactivation of glyceraldehyde-3-phosphate dehydrogenase (G-3PD), a key glycolytic enzyme, when the cells were treated with a bolus of hydrogen peroxide, prompted our speculation that G-3PD may have been transiently thiolated at the SH sensitive active center.	Sulfhydryl Compounds	36-41	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	358-363
10930123-1	2000	We examined the mechanism of nitric oxide (NO) and/or superoxide (O2-)-induced cytotoxicity and the importance of thiols in endothelial cells by treating the cells with superoxide dismutase (SOD), catalase (CAT) and hemoglobin (Hb).	Sulfhydryl Compounds	114-120	superoxide dismutase 1	Homo sapiens	191-194
10843779-2	2000	In the meantime, thioltransferase (TTase), a thiol regulating enzyme, whose activity remained constant under the same condition, may be regulating G-3PD and other sulfhydryl-sensitive glycolytic enzymes through thiol-disulfide exchange reactions ( Lou et al., 1998 ).	Sulfhydryl Compounds	17-22	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	147-152
10843779-2	2000	In the meantime, thioltransferase (TTase), a thiol regulating enzyme, whose activity remained constant under the same condition, may be regulating G-3PD and other sulfhydryl-sensitive glycolytic enzymes through thiol-disulfide exchange reactions ( Lou et al., 1998 ).	Sulfhydryl Compounds	45-50	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	147-152
10820281-0	2000	Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase.	Sulfhydryl Compounds	0-5	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	39-49
10820281-10	2000	Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity.	Sulfhydryl Compounds	92-97	conserved helix-loop-helix ubiquitous kinase	Mus musculus	39-48
10820281-10	2000	Two catalytic subunits of IKK complex, IKK alpha and IKK beta, were both inhibited by these thiol-modifying agents, suggesting the presence of a cysteine sulfhydryl group in these subunits, which is critical for enzyme activity.	Sulfhydryl Compounds	92-97	inhibitor of kappaB kinase beta	Mus musculus	53-61
10745207-4	2000	Glutathione excretion is also triggered by overexpression of Kar2p/BiP, a native ER-resident protein-folding chaperone, indicating that the response is a general one not restricted to overexpression of thiol-containing heterologous proteins.	Sulfhydryl Compounds	202-207	Hsp70 family ATPase KAR2	Saccharomyces cerevisiae S288C	61-66
10925209-5	2000	The thiol antioxidant, N-acetylcysteine (NAC) abolished the synergism between IL-1beta or IL-6 and 1,25(OH)(2)D(3), but had only a small protective effect when the cytokines acted alone.	Sulfhydryl Compounds	4-9	synuclein alpha	Homo sapiens	41-44
10942212-8	2000	Taken together, the above results are consistent with the possibility that covalent binding of the reagent with a thiol group of cysteine is a critical event for the DHA-mediated loss of hexokinase activity.	Sulfhydryl Compounds	114-119	hexokinase 1	Homo sapiens	187-197
10925209-5	2000	The thiol antioxidant, N-acetylcysteine (NAC) abolished the synergism between IL-1beta or IL-6 and 1,25(OH)(2)D(3), but had only a small protective effect when the cytokines acted alone.	Sulfhydryl Compounds	4-9	interleukin 1 beta	Homo sapiens	78-86
10925209-5	2000	The thiol antioxidant, N-acetylcysteine (NAC) abolished the synergism between IL-1beta or IL-6 and 1,25(OH)(2)D(3), but had only a small protective effect when the cytokines acted alone.	Sulfhydryl Compounds	4-9	interleukin 6	Homo sapiens	90-100
10839186-0	2000	Naked Au55 clusters: dramatic effect of a thiol-terminated dendrimer Reaction of the thiol-terminated fourth-generation dendrimer 2-G4 (96 SH groups) with the gold cluster compound Au55(PPh3)12Cl6 in a 3:1 molar ratio in dichloromethane results in the formation of bare Au55 clusters.	Sulfhydryl Compounds	42-47	caveolin 1	Homo sapiens	186-190
10847613-3	2000	Addition of DTNB to cells followed by disulfide addition directly measures the formation of newly reduced thiol.	Sulfhydryl Compounds	106-111	dystrobrevin beta	Homo sapiens	12-16
10788478-2	2000	The stress protein heme oxygenase-1 (HO-1) is induced in endothelial cells exposed to nitric oxide (NO)-releasing agents, and this process is finely modulated by thiols (Foresti, R., Clark, J. E., Green, C. J., and Motterlini R. (1997) J. Biol.	Sulfhydryl Compounds	162-168	heme oxygenase 1	Homo sapiens	19-35
10788478-2	2000	The stress protein heme oxygenase-1 (HO-1) is induced in endothelial cells exposed to nitric oxide (NO)-releasing agents, and this process is finely modulated by thiols (Foresti, R., Clark, J. E., Green, C. J., and Motterlini R. (1997) J. Biol.	Sulfhydryl Compounds	162-168	heme oxygenase 1	Homo sapiens	37-41
10788478-8	2000	A series of antioxidant agents did not prevent the elevation in heme oxygenase activity by hypoxia; however, the precursor of glutathione synthesis and thiol donor, N-acetylcysteine, completely abolished HO-1 induction.	Sulfhydryl Compounds	152-157	heme oxygenase 1	Homo sapiens	204-208
10788478-10	2000	These results indicate that intracellular interaction of thiols with NO is an important determinant in the mechanism leading to HO-1 induction by reduced oxygen levels.	Sulfhydryl Compounds	57-63	heme oxygenase 1	Homo sapiens	128-132
10748083-3	2000	Mercury-containing sulfhydryl modification agents (rho-hydroxymercuribenzoate and mercuric chloride) irreversibly inhibit the ROC1-CUL1 ubiquitin ligase activity without disrupting the complex.	Sulfhydryl Compounds	19-29	ring-box 1	Homo sapiens	126-130
10748083-3	2000	Mercury-containing sulfhydryl modification agents (rho-hydroxymercuribenzoate and mercuric chloride) irreversibly inhibit the ROC1-CUL1 ubiquitin ligase activity without disrupting the complex.	Sulfhydryl Compounds	19-29	cullin 1	Homo sapiens	131-135
10812071-1	2000	In the presence of denaturant and thiol initiator, the native bovine pancreatic trypsin inhibitor (BPTI) denatures by shuffling its native disulfide bonds and converts to a mixture of scrambled isomers.	Sulfhydryl Compounds	34-39	spleen trypsin inhibitor I	Bos taurus	99-103
10839186-0	2000	Naked Au55 clusters: dramatic effect of a thiol-terminated dendrimer Reaction of the thiol-terminated fourth-generation dendrimer 2-G4 (96 SH groups) with the gold cluster compound Au55(PPh3)12Cl6 in a 3:1 molar ratio in dichloromethane results in the formation of bare Au55 clusters.	Sulfhydryl Compounds	85-90	caveolin 1	Homo sapiens	186-190
10823686-0	2000	Effects of sulfhydryl compounds on interleukin-1-induced vascular endothelial growth factor production in human synovial stromal cells.	Sulfhydryl Compounds	11-31	interleukin 1 alpha	Homo sapiens	35-48
10823686-0	2000	Effects of sulfhydryl compounds on interleukin-1-induced vascular endothelial growth factor production in human synovial stromal cells.	Sulfhydryl Compounds	11-31	vascular endothelial growth factor A	Homo sapiens	57-91
10823686-1	2000	We investigated the effects of various sulfhydryl compounds on interleukin-1 (IL-1)-induced vascular endothelial growth factor (VEGF) production in human synovial stromal cells (HSSC).	Sulfhydryl Compounds	39-49	interleukin 1 alpha	Homo sapiens	63-82
10823686-1	2000	We investigated the effects of various sulfhydryl compounds on interleukin-1 (IL-1)-induced vascular endothelial growth factor (VEGF) production in human synovial stromal cells (HSSC).	Sulfhydryl Compounds	39-49	vascular endothelial growth factor A	Homo sapiens	92-126
10813721-14	2000	CONCLUSIONS: This study demonstrates that thiol depletion can be used as an effective means of activating caspase-3 in both androgen sensitive and insensitive prostate carcinoma cells.	Sulfhydryl Compounds	42-47	caspase 3	Homo sapiens	106-115
10811113-7	2000	Furthermore, in both models of apoptosis, NO-releasing compounds dose-dependently reduced: (a) the number of the titratable thiol groups (cysteine residues) of c-Jun; (b) induction of AP-1 DNA-binding activity; (c) AP-1-driven transactivation of the CD95L promoter; and (d) caspase activation.	Sulfhydryl Compounds	124-129	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-165
10820057-6	2000	These results suggest that BSA forms disulfide-bonded aggregates that contain available thiol groups that can catalyze the formation of differently structured alpha-La monomers, dimers, higher polymers, and adducts of alpha-La with BSA.	Sulfhydryl Compounds	88-93	lactalbumin alpha	Homo sapiens	159-167
10813654-9	2000	The reaction pathways of PAT with NAC were qualitatively the same as those previously observed for the aliphatic thiol model compound 2-mercaptoethanol.	Sulfhydryl Compounds	113-118	X-linked Kx blood group	Homo sapiens	34-37
10866285-1	2000	PURPOSE: This study tests the hypothesis that p53 status, i.e. wild type versus mutant form, is a determinant in radiation protection of human glioma cells by WR-1065, the active thiol form of amifostine (WR-2721).	Sulfhydryl Compounds	179-184	tumor protein p53	Homo sapiens	46-49
10820057-6	2000	These results suggest that BSA forms disulfide-bonded aggregates that contain available thiol groups that can catalyze the formation of differently structured alpha-La monomers, dimers, higher polymers, and adducts of alpha-La with BSA.	Sulfhydryl Compounds	88-93	lactalbumin alpha	Homo sapiens	218-226
10692565-6	2000	AP-1 and NF-kappaB activation were blocked by the thiol antioxidant N-acetylcysteine and by nordihydroguaiaretic acid, an antioxidant and lipooxygenase inhibitor and an inhibitor of the epoxygenase activity of CYP1A1, and did not take place in c35, c37, or in Ah nuclear translator-deficient c4 cells.	Sulfhydryl Compounds	50-55	jun proto-oncogene	Mus musculus	0-4
10756189-5	2000	Introduction of cysteine residues at other sites in the PKR RBD allows for site-specific modification with thiol-selective reagents.	Sulfhydryl Compounds	107-112	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	56-59
10692565-6	2000	AP-1 and NF-kappaB activation were blocked by the thiol antioxidant N-acetylcysteine and by nordihydroguaiaretic acid, an antioxidant and lipooxygenase inhibitor and an inhibitor of the epoxygenase activity of CYP1A1, and did not take place in c35, c37, or in Ah nuclear translator-deficient c4 cells.	Sulfhydryl Compounds	50-55	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	210-216
11232595-3	2000	Most challenging is understanding the relationship for how specific sulfhydryl moieties ascribe specific aspects of RyR function.	Sulfhydryl Compounds	68-78	ryanodine receptor 2	Homo sapiens	116-119
10754306-3	2000	We have found that L-selectin shedding is sensitive to sulfhydryl chemistry; it is promoted by thiol-oxidizing or -blocking reagents and inhibited by reducing reagents.	Sulfhydryl Compounds	95-100	selectin L	Homo sapiens	19-29
10766422-4	2000	Taken together, our data suggest that differentiation status may play a pivotal role in modulating intracellular thiol redox status and the extent of catalase expression, which may be crucial in the control of NF-kappaB activity in these HCC cells.	Sulfhydryl Compounds	113-118	nuclear factor kappa B subunit 1	Homo sapiens	210-219
11232603-2	2000	Phenoxyl radicals produced this way or from metabolism by peroxidases, tyrosinase, or mixed-function oxidases, however, may react with sulfhydryl groups of proteins and other endogenous thiols.	Sulfhydryl Compounds	186-192	tyrosinase	Homo sapiens	71-81
11232595-5	2000	A small number of hyperreactive thiols have been shown to exist within the RyR complex.	Sulfhydryl Compounds	32-38	ryanodine receptor 2	Homo sapiens	75-78
11232603-0	2000	Reversible thiol-dependent activation of ryanodine-sensitive Ca2+ release channel by etoposide (VP-16) phenoxyl radical.	Sulfhydryl Compounds	11-16	host cell factor C1	Homo sapiens	96-101
10720769-4	2000	The data indicate that activation of hsp70 is linked to changes in thiol-disulfide redox perturbations while grp78 activation may be caused by loss of calcium from the endoplasmic reticulum.	Sulfhydryl Compounds	67-72	heat shock protein family A (Hsp70) member 4	Homo sapiens	37-42
10741850-7	2000	Potential signaling mechanisms mediating GCS gene induction by the diverse families of Phase II enzyme inducers include thiol modification of critical regulatory sensor protein(s) and the generation of the reactive oxygen species.	Sulfhydryl Compounds	120-125	glutamate-cysteine ligase catalytic subunit	Homo sapiens	41-44
10803424-12	2000	We conclude that TTase can regulate and repair the thiols in lens proteins and enzymes through its dethiolase activity, thus contributing to the maintenance of the function of the lens.	Sulfhydryl Compounds	51-57	glutaredoxin	Homo sapiens	17-22
10775561-3	2000	The effect of N-acetyl-L-cysteine on potentiating interleukin-1beta-induced nitrite production and iNOS expression was mimicked either by the enantiomers, L-cysteine and D-cysteine, or by a non-thiol-containing antioxidant, L-ascorbic acid.	Sulfhydryl Compounds	194-199	interleukin 1 beta	Rattus norvegicus	50-67
10734129-3	2000	Two proteins that presented free thiol(s) on the activated platelet surface were protein-disulfide isomerase (PDI) and glycoprotein 1balpha (GP1balpha).	Sulfhydryl Compounds	33-38	prolyl 4-hydroxylase subunit beta	Homo sapiens	81-108
10734129-3	2000	Two proteins that presented free thiol(s) on the activated platelet surface were protein-disulfide isomerase (PDI) and glycoprotein 1balpha (GP1balpha).	Sulfhydryl Compounds	33-38	prolyl 4-hydroxylase subunit beta	Homo sapiens	110-113
10734129-3	2000	Two proteins that presented free thiol(s) on the activated platelet surface were protein-disulfide isomerase (PDI) and glycoprotein 1balpha (GP1balpha).	Sulfhydryl Compounds	33-38	glycoprotein Ib platelet subunit alpha	Homo sapiens	141-150
10734129-6	2000	Similarly, GP1balpha presented one or more free thiols on the activated platelet surface but not on resting platelets.	Sulfhydryl Compounds	48-54	GTP binding protein 1	Homo sapiens	11-14
10734129-9	2000	These observations indicated that platelet activation triggered reduction of the active site disulfides of PDI and a conformational change in GP1balpha that resulted in exposure of a free thiol(s).	Sulfhydryl Compounds	188-193	GTP binding protein 1	Homo sapiens	142-145
10694579-0	2000	The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism.	Sulfhydryl Compounds	109-114	Cup2p	Saccharomyces cerevisiae S288C	73-77
10694579-3	2000	A mechanism is proposed whereby the metal binding thiols of Ace1 are chemically modified via NO- and O(2)-dependent chemistry, thereby diminishing the ability of Ace1 to bind and respond to copper.	Sulfhydryl Compounds	50-56	Cup2p	Saccharomyces cerevisiae S288C	60-64
10694579-3	2000	A mechanism is proposed whereby the metal binding thiols of Ace1 are chemically modified via NO- and O(2)-dependent chemistry, thereby diminishing the ability of Ace1 to bind and respond to copper.	Sulfhydryl Compounds	50-56	Cup2p	Saccharomyces cerevisiae S288C	162-166
10694468-2	2000	The rabbit brain endooligopeptidase A and the rat testes soluble metallopeptidase (EC 3.4.24.15) are thiol-activated oligopeptidases which are able to generate enkephalin from a number of opioid peptides and to inactivate bradykinin and neurotensin by hydrolyzing the same peptide bonds.	Sulfhydryl Compounds	101-106	endothelin converting enzyme-like 1	Rattus norvegicus	65-81
10692416-4	2000	Recently we found that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO(+) (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA binding of IRP-2 followed by IRP-2 degradation, and these changes were associated with a decrease in TfR mRNA levels (Kim, S., and Ponka, P. (1999) J. Biol.	Sulfhydryl Compounds	145-150	iron responsive element binding protein 2	Mus musculus	206-211
10694468-2	2000	The rabbit brain endooligopeptidase A and the rat testes soluble metallopeptidase (EC 3.4.24.15) are thiol-activated oligopeptidases which are able to generate enkephalin from a number of opioid peptides and to inactivate bradykinin and neurotensin by hydrolyzing the same peptide bonds.	Sulfhydryl Compounds	101-106	proenkephalin	Rattus norvegicus	160-170
10692416-4	2000	Recently we found that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO(+) (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA binding of IRP-2 followed by IRP-2 degradation, and these changes were associated with a decrease in TfR mRNA levels (Kim, S., and Ponka, P. (1999) J. Biol.	Sulfhydryl Compounds	145-150	iron responsive element binding protein 2	Mus musculus	224-229
10692416-4	2000	Recently we found that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO(+) (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA binding of IRP-2 followed by IRP-2 degradation, and these changes were associated with a decrease in TfR mRNA levels (Kim, S., and Ponka, P. (1999) J. Biol.	Sulfhydryl Compounds	145-150	transferrin receptor	Mus musculus	296-299
10753451-8	2000	The protein adsorption data demonstrated that the disulfide moieties of the modified microspheres react with the thiol moieties of the reduced RNase A to form a mixed disulfide.	Sulfhydryl Compounds	113-118	ribonuclease A family member 1, pancreatic	Homo sapiens	143-150
10666306-6	2000	GmGlyox I was active toward the hemithioacetal adducts formed by reacting methylglyoxal, or phenylglyoxal, with glutathione, homoglutathione, or gamma-glutamylcysteine, showing no preference for homoglutathione adducts over glutathione adducts, even though homoglutathione is the dominant thiol in soybean.	Sulfhydryl Compounds	289-294	lactoylglutathione lyase	Glycine max	0-9
10731722-1	2000	Peroxiredoxins (PRxs) play a role in protecting protein free thiol groups against oxidative damage and thioredoxin-dependent peroxidase activity.	Sulfhydryl Compounds	61-66	peroxiredoxin 4	Homo sapiens	0-14
10746948-8	2000	Flow cytometric measurements of intracellular sulfhydryl levels strongly suggested that N-acetylcysteine and WR-1065 are preventive in alkylation of cellular compounds, mainly by direct extracellular interaction with HN2.	Sulfhydryl Compounds	46-56	MT-RNR2 like 2 (pseudogene)	Homo sapiens	217-220
10713709-8	2000	These data indicate that WR1065, a polyamine analog with thiol anti-oxidant properties, activates a cell cycle check-point involving p53.	Sulfhydryl Compounds	57-62	tumor protein p53	Homo sapiens	133-136
10713556-4	2000	The interaction of PDSG with catalase in water and in phosphate buffer was accompanied by significant changes in CD spectra in the far UV-region that indicated disturbances in the secondary structure of catalase subunits induced by the bioantioxidant; the latter was suggested to initiate the reaction of thiol--disulfide exchange with the enzyme.	Sulfhydryl Compounds	305-310	catalase	Homo sapiens	29-37
10699753-7	2000	Electrophilic attack of the albumin-associated thiols by reactive nitrogen oxides formed from the interaction of NO with O(2) was ruled out because one would have expected 50% yield of AlbSNO.	Sulfhydryl Compounds	47-53	albumin	Homo sapiens	28-35
10639574-5	2000	Activity of the purified rhTK(ATP) was enhanced by addition of thiols including DTT, cysteine, homocysteine and beta-mercaptoethanol but inhibited by various sulfhydryl reagents such as 5,5"-dithio-bis(2-nitrobenzoic acid).	Sulfhydryl Compounds	63-69	ATPase phospholipid transporting 8A2	Homo sapiens	25-34
10677484-1	2000	This paper describes the placement of a crosslinking agent (dibromobimane) between two thiols (Cys-522 and Cys-707) of a fragment, "S1," of the motor protein, myosin.	Sulfhydryl Compounds	87-93	myosin heavy chain 14	Homo sapiens	159-165
10698448-1	2000	Four primary zinc-binding pharmacophores (thiols, carboxylates, phosphorus acids, and hydroxamates) have been utilized in generating inhibitors of zinc metalloproteases such as ACE, NEP, the MMPs, and ECE.	Sulfhydryl Compounds	42-48	angiotensin I converting enzyme	Homo sapiens	177-180
10698448-1	2000	Four primary zinc-binding pharmacophores (thiols, carboxylates, phosphorus acids, and hydroxamates) have been utilized in generating inhibitors of zinc metalloproteases such as ACE, NEP, the MMPs, and ECE.	Sulfhydryl Compounds	42-48	endothelin converting enzyme 1	Homo sapiens	201-204
10698448-2	2000	Although compounds which inhibit the activity of both ACE and NEP (vasopeptidase inhibitors, VPIs) have been reported which incorporate a thiol, carboxylate, or phosphorus acid pharmacophore, the generation of hydroxamate based vasopeptidase inhibitors has remained elusive.	Sulfhydryl Compounds	138-143	angiotensin I converting enzyme	Homo sapiens	54-57
10698448-2	2000	Although compounds which inhibit the activity of both ACE and NEP (vasopeptidase inhibitors, VPIs) have been reported which incorporate a thiol, carboxylate, or phosphorus acid pharmacophore, the generation of hydroxamate based vasopeptidase inhibitors has remained elusive.	Sulfhydryl Compounds	138-143	membrane metalloendopeptidase	Homo sapiens	62-65
10713556-4	2000	The interaction of PDSG with catalase in water and in phosphate buffer was accompanied by significant changes in CD spectra in the far UV-region that indicated disturbances in the secondary structure of catalase subunits induced by the bioantioxidant; the latter was suggested to initiate the reaction of thiol--disulfide exchange with the enzyme.	Sulfhydryl Compounds	305-310	catalase	Homo sapiens	203-211
10667918-7	2000	The results suggest that S-Nitrosylation or oxidation of at least three classes of protein thiols by NO each produced characteristic changes in RyR activity.	Sulfhydryl Compounds	91-97	ryanodine receptor 1	Homo sapiens	144-147
10651998-5	2000	Phenoxyl radicals are readily reduced by thiols, ascorbate, and other intracellular reductants (e.g., NADH, NADPH) regenerating the parent phenolic compound.	Sulfhydryl Compounds	41-47	2,4-dienoyl-CoA reductase 1	Homo sapiens	108-113
10699356-1	2000	Mercuric ion (Hg(2+)), a potent thiol inhibitor, prevents expression of nuclear factor kappaB (NF-kappaB) by mercaptide bond formation with a critical cysteine moiety (cys(62)) on the p50 subunit required for DNA binding.	Sulfhydryl Compounds	32-37	nuclear factor kappa B subunit 1	Homo sapiens	95-104
10708650-1	2000	The cysteine residue at F9(93) of the human hemoglobin (Hb A) beta chain, conserved in mammalian and avian hemoglobins, is located near the functionally important alpha1-beta2 interface and C-terminal region of the beta chain and is reactive to sulfhydryl reagents.	Sulfhydryl Compounds	245-255	sodium voltage-gated channel alpha subunit 2	Homo sapiens	56-60
10699356-2	2000	NF-kappaB-DNA binding is typically measured in reaction mixtures in which dithiothreitol (DTT) or other thiol reductants are used to maintain cys(62) in the reduced state.	Sulfhydryl Compounds	104-109	nuclear factor kappa B subunit 1	Homo sapiens	0-9
10699356-3	2000	However, the presence of thiol reductants prevents accurate assessment of the Hg(2+) concentration required to prevent NF-kappaB-DNA binding because of competitive mercaptide bond formation.	Sulfhydryl Compounds	25-30	nuclear factor kappa B subunit 1	Homo sapiens	119-128
10625487-11	2000	We speculate that APT was sensitive to AMVN and/or NO via modification of protein thiols critical for functional activity.	Sulfhydryl Compounds	82-88	ATPase phospholipid transporting 8A1	Homo sapiens	18-21
10644761-0	2000	Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family.	Sulfhydryl Compounds	125-130	thioredoxin	Homo sapiens	0-11
10644761-0	2000	Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family.	Sulfhydryl Compounds	125-130	opsin 1, short wave sensitive	Homo sapiens	59-95
10644761-0	2000	Thioredoxin-dependent hydroperoxide peroxidase activity of bacterioferritin comigratory protein (BCP) as a new member of the thiol-specific antioxidant protein (TSA)/Alkyl hydroperoxide peroxidase C (AhpC) family.	Sulfhydryl Compounds	125-130	opsin 1, short wave sensitive	Homo sapiens	97-100
10636927-8	2000	One cysteine residue (Cys(204)) in the first hybrid domain of fibrillin-1 was found to occur as a free thiol and is therefore a good candidate for intermolecular disulfide bonding in initial steps of the assembly process.	Sulfhydryl Compounds	103-108	fibrillin 1	Gallus gallus	62-73
10636927-9	2000	Furthermore, evidence indicated that the comparable cysteine residue in fibrillin-2 (Cys(233)) also occurs as a free thiol.	Sulfhydryl Compounds	117-122	fibrillin 2	Gallus gallus	72-83
10644709-0	2000	Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism.	Sulfhydryl Compounds	99-104	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	22-27
10644709-0	2000	Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism.	Sulfhydryl Compounds	99-104	mitogen-activated protein kinase 8	Homo sapiens	79-87
10644709-9	2000	Taken together, our findings strongly suggest that selenite differentially modulates the mammalian mitogen-activated protein kinase pathways and that it can repress the JNK/SAPK signaling pathway by inhibiting JNK/SAPK through a thiol redox mechanism.	Sulfhydryl Compounds	229-234	mitogen-activated protein kinase 8	Homo sapiens	169-172
10644709-9	2000	Taken together, our findings strongly suggest that selenite differentially modulates the mammalian mitogen-activated protein kinase pathways and that it can repress the JNK/SAPK signaling pathway by inhibiting JNK/SAPK through a thiol redox mechanism.	Sulfhydryl Compounds	229-234	mitogen-activated protein kinase 8	Homo sapiens	169-177
10656697-5	2000	Bcl-2 overproduction in PC12 cells is associated with increased functional thiol reserves, increased reductive activation of chemotherapeutic prodrugs, and GSH accumulation after treatment with N-acetylcysteine.	Sulfhydryl Compounds	75-80	BCL2, apoptosis regulator	Rattus norvegicus	0-5
10645010-0	2000	Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis.	Sulfhydryl Compounds	24-29	solute carrier family 25 member 6	Homo sapiens	45-76
10645010-0	2000	Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis.	Sulfhydryl Compounds	24-29	BCL2 apoptosis regulator	Homo sapiens	86-91
10645010-3	2000	Here we show that thiol crosslinking agents including diazenedicarboxylic acid bis 5N, N-dimethylamide (diamide), dithiodipyridine (DTDP), or bis-maleimido-hexane (BMH) can act on the adenine nucleotide translocator (ANT), one of the proteins within the PTPC.	Sulfhydryl Compounds	18-23	solute carrier family 25 member 6	Homo sapiens	184-215
10645010-8	2000	Concomitantly, a series of different thiol crosslinking agents (diamide, DTDP, and BMH, phenylarsine oxide) but not tert-butylhydroperoxide or arsenite induce mitochondrial membrane permeabilization and cell death irrespective of the expression level of Bcl-2.	Sulfhydryl Compounds	37-42	BCL2 apoptosis regulator	Homo sapiens	254-259
10645010-9	2000	These data indicate that thiol crosslinkers cause a covalent modification of ANT which, beyond any control by Bcl-2, leads to mitochondrial membrane permeabilization and cell death.	Sulfhydryl Compounds	25-30	BCL2 apoptosis regulator	Homo sapiens	110-115
10949665-5	2000	The thiol inhibitor MAG-283 had IC50 values of 480 nM and 3 nM against human interstitial collagenase (MMP-1) and MMP-2, respectively, and KI value of 2.2 nM against MMP-9.	Sulfhydryl Compounds	4-9	matrix metallopeptidase 1	Homo sapiens	103-108
11281283-9	2000	The reduction in eNOS sulfhydryl content and the inhibitory effect of PAO on eNOS activity were prevented by dithiothreitol, a disulfide-reducing agent.	Sulfhydryl Compounds	22-32	nitric oxide synthase 3	Bos taurus	17-21
11281283-10	2000	These results indicate that (i) PAO directly inhibits eNOS activity in endothelial cells by binding to thiol groups in the eNOS protein and (ii) results of studies using PAO to assess the role of protein tyrosine phosphorylation in regulating eNOS activity must be interpreted with great caution.	Sulfhydryl Compounds	103-108	nitric oxide synthase 3	Bos taurus	54-58
11281283-10	2000	These results indicate that (i) PAO directly inhibits eNOS activity in endothelial cells by binding to thiol groups in the eNOS protein and (ii) results of studies using PAO to assess the role of protein tyrosine phosphorylation in regulating eNOS activity must be interpreted with great caution.	Sulfhydryl Compounds	103-108	nitric oxide synthase 3	Bos taurus	123-127
11281283-10	2000	These results indicate that (i) PAO directly inhibits eNOS activity in endothelial cells by binding to thiol groups in the eNOS protein and (ii) results of studies using PAO to assess the role of protein tyrosine phosphorylation in regulating eNOS activity must be interpreted with great caution.	Sulfhydryl Compounds	103-108	nitric oxide synthase 3	Bos taurus	123-127
11281283-3	2000	Phenylarsine oxide (PAO), an inhibitor of TP, has been reported to bind thiol groups, and recent work from our laboratory demonstrates that eNOS activity depends on thiol groups at its catalytic site.	Sulfhydryl Compounds	72-77	nitric oxide synthase 3	Bos taurus	140-144
11281283-3	2000	Phenylarsine oxide (PAO), an inhibitor of TP, has been reported to bind thiol groups, and recent work from our laboratory demonstrates that eNOS activity depends on thiol groups at its catalytic site.	Sulfhydryl Compounds	165-170	nitric oxide synthase 3	Bos taurus	140-144
10800594-4	2000	Thioredoxin of mediated thiol-disulfide exchange interconverts eukaryotic PRKs between reduced (active) and oxidized (inactive) forms.	Sulfhydryl Compounds	24-29	thioredoxin	Homo sapiens	0-11
10619832-4	2000	In addition, we also examined the effect of a thiol-reducing agent, N-acetylcysteine (NAC), on DEP-induced p38 MAP kinase activation and cytokine production in order to clarify the redox control mechanism in DEP-induced p38 MAP kinase activation and IL-8 and RANTES production.	Sulfhydryl Compounds	46-51	mitogen-activated protein kinase 14	Homo sapiens	107-110
10949665-5	2000	The thiol inhibitor MAG-283 had IC50 values of 480 nM and 3 nM against human interstitial collagenase (MMP-1) and MMP-2, respectively, and KI value of 2.2 nM against MMP-9.	Sulfhydryl Compounds	4-9	matrix metallopeptidase 2	Homo sapiens	114-119
10949665-5	2000	The thiol inhibitor MAG-283 had IC50 values of 480 nM and 3 nM against human interstitial collagenase (MMP-1) and MMP-2, respectively, and KI value of 2.2 nM against MMP-9.	Sulfhydryl Compounds	4-9	matrix metallopeptidase 9	Homo sapiens	166-171
11213481-7	2000	This reduction in nitrite production by EMS added at 3 hr may be due to the direct modification of thiol groups on the iNOS protein because we have determined that iNOS activity is inhibited by the sulfhydryl modifying reagent N-ethylmaleimide (NEM).	Sulfhydryl Compounds	99-104	nitric oxide synthase 2	Rattus norvegicus	119-123
11213474-1	2000	Thioredoxin (TRX), a thiol-containing protein, is induced by various oxidative stresses.	Sulfhydryl Compounds	21-26	thioredoxin	Homo sapiens	0-11
11213481-7	2000	This reduction in nitrite production by EMS added at 3 hr may be due to the direct modification of thiol groups on the iNOS protein because we have determined that iNOS activity is inhibited by the sulfhydryl modifying reagent N-ethylmaleimide (NEM).	Sulfhydryl Compounds	99-104	nitric oxide synthase 2	Rattus norvegicus	164-168
11213474-1	2000	Thioredoxin (TRX), a thiol-containing protein, is induced by various oxidative stresses.	Sulfhydryl Compounds	21-26	thioredoxin	Homo sapiens	13-16
11213481-10	2000	Based on our results with mRNA levels, both DTT and depletion of cellular GSH appear to inhibit the early signaling events leading to iNOS expression and suggest that the control of iNOS induction in hepatocytes is sensitive to the thiol redox status of the cell.	Sulfhydryl Compounds	232-237	nitric oxide synthase 2	Rattus norvegicus	134-138
11213481-10	2000	Based on our results with mRNA levels, both DTT and depletion of cellular GSH appear to inhibit the early signaling events leading to iNOS expression and suggest that the control of iNOS induction in hepatocytes is sensitive to the thiol redox status of the cell.	Sulfhydryl Compounds	232-237	nitric oxide synthase 2	Rattus norvegicus	182-186
10842745-7	2000	The ubiquitous endogenous thiols thioredoxin and glutathione are of central importance in redox signaling.	Sulfhydryl Compounds	26-32	thioredoxin	Homo sapiens	33-44
11054653-1	2000	A novel thiol-specific spin labeling procedure for the protein component (apoprotein B, apoB) of low density lipoproteins (LDLs) is presented.	Sulfhydryl Compounds	8-13	apolipoprotein B	Homo sapiens	88-92
11054653-4	2000	The suitability of thiol-specific labeling for the study of the stability and conformation of apoB was demonstrated in experiments with denaturing agents.	Sulfhydryl Compounds	19-24	apolipoprotein B	Homo sapiens	94-98
10842745-13	2000	Intracellular calcium homeostasis is regulated by the redox state of cellular thiols, and it is evident that cell calcium may play a critical role in the activation of the redox-sensitive transcription factor NF-kappa B.	Sulfhydryl Compounds	78-84	nuclear factor kappa B subunit 1	Homo sapiens	209-219
10842751-2	2000	Thiol antioxidants act through a variety of mechanisms, including (1) as components of the general thiol/disulfide redox buffer, (2) as metal chelators, (3) as radical quenchers, (4) as substrates for specific redox reactions (GSH), and (5) as specific reductants of individual protein disulfate bonds (thioredoxin).	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	303-314
10842751-5	2000	Cells have devised a number of mechanisms to promote increased intracellular levels of thiols such as GSH and thioredoxin in response to a wide variety of stresses.	Sulfhydryl Compounds	87-93	thioredoxin	Homo sapiens	110-121
10615013-0	1999	Cathepsin Y (a novel thiol enzyme) produces kinin potentiating peptide from the component protein of rat plasma.	Sulfhydryl Compounds	21-26	cathepsin Z	Rattus norvegicus	0-11
10567914-0	2000	Human thioredoxin attenuates hypoxia-reoxygenation injury of murine endothelial cells in a thiol-free condition.	Sulfhydryl Compounds	91-96	thioredoxin 1	Mus musculus	6-17
10567914-11	2000	Because the cytoprotective effect of ADF/hTRX occurs in the thiol-free condition, it must be mediated via a novel mechanism other than enhancing thiol uptake.	Sulfhydryl Compounds	60-65	thioredoxin	Homo sapiens	37-40
10567914-11	2000	Because the cytoprotective effect of ADF/hTRX occurs in the thiol-free condition, it must be mediated via a novel mechanism other than enhancing thiol uptake.	Sulfhydryl Compounds	60-65	thioredoxin	Homo sapiens	41-45
10567914-11	2000	Because the cytoprotective effect of ADF/hTRX occurs in the thiol-free condition, it must be mediated via a novel mechanism other than enhancing thiol uptake.	Sulfhydryl Compounds	145-150	thioredoxin	Homo sapiens	37-40
10635343-3	1999	The mutagenesis by low doses of CYS, CYSGLY and GSH + GGT detected in IC203 was abolished by rat liver S9, through the activity of catalase, as well as by the metal chelator diethyldithiocarbamate (DETC), supporting the dependence of this mutagenesis on H2O2 production, probably in thiol autoxidation reactions in which transition metals are involved.	Sulfhydryl Compounds	283-288	catalase	Rattus norvegicus	131-139
10620110-5	2000	In contrast, tyrosinase activity in an amelanotic melanoma cell line (MM96L) was rapidly inhibited without consumption of cystamine/cysteamine, in association with the generation of free thiol in the culture medium, and could be enhanced by the cystine transport inhibitor, glutamate.	Sulfhydryl Compounds	187-192	tyrosinase	Homo sapiens	13-23
10620110-10	2000	In amelanotic cells, tyrosinase has a short half-life and is readily inhibited by cystamine/cysteamine whereas tyrosinase in the more mature melanosomes of the pigmented cell appears to be less accessible to proteolytic and thiol attack.	Sulfhydryl Compounds	224-229	tyrosinase	Homo sapiens	21-31
10620110-10	2000	In amelanotic cells, tyrosinase has a short half-life and is readily inhibited by cystamine/cysteamine whereas tyrosinase in the more mature melanosomes of the pigmented cell appears to be less accessible to proteolytic and thiol attack.	Sulfhydryl Compounds	224-229	tyrosinase	Homo sapiens	111-121
10854765-4	2000	The sulfhydryl reducing agent dithiothreitol reversibly potentiated the responses of various combinations of functional recombinant GABA(A) subunits, whether expressed as triplets (alpha(1)beta(1-3)gamma(1,2S)), pairs (alpha(1-3)beta(1-3); beta(1-3)gamma(1,2S)), or singly (beta(2)).	Sulfhydryl Compounds	4-14	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	189-197
10854765-4	2000	The sulfhydryl reducing agent dithiothreitol reversibly potentiated the responses of various combinations of functional recombinant GABA(A) subunits, whether expressed as triplets (alpha(1)beta(1-3)gamma(1,2S)), pairs (alpha(1-3)beta(1-3); beta(1-3)gamma(1,2S)), or singly (beta(2)).	Sulfhydryl Compounds	4-14	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	229-237
10854765-4	2000	The sulfhydryl reducing agent dithiothreitol reversibly potentiated the responses of various combinations of functional recombinant GABA(A) subunits, whether expressed as triplets (alpha(1)beta(1-3)gamma(1,2S)), pairs (alpha(1-3)beta(1-3); beta(1-3)gamma(1,2S)), or singly (beta(2)).	Sulfhydryl Compounds	4-14	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	229-237
10585407-6	1999	Direct evidence for binding of drug substrate was then determined by cysteine-scanning mutagenesis of the residues in TM11 and inhibition of drug-stimulated ATPase activity by dibromobimane, a thiol-reactive substrate.	Sulfhydryl Compounds	193-198	dynein axonemal heavy chain 8	Homo sapiens	157-163
10628931-1	1999	OBJECTIVE: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including Azathioprine (AZA).	Sulfhydryl Compounds	148-168	thiopurine S-methyltransferase	Homo sapiens	11-41
10628931-1	1999	OBJECTIVE: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including Azathioprine (AZA).	Sulfhydryl Compounds	148-168	thiopurine S-methyltransferase	Homo sapiens	43-47
10569948-10	1999	Considering the high concentration of reduced glutathione in human cells (about 10 mM), the physiological form of hGSTA1-1 is most likely the thiol-complexed protein with a stabilized helix9.	Sulfhydryl Compounds	142-147	glutathione S-transferase alpha 1	Homo sapiens	114-122
10582588-3	1999	We describe a general mechanism whereby the enzymatic metabolism of neurotransmitters by monoamine oxidase (MAO) damages mitochondria, altering their protein thiol status and suppressing respiration.	Sulfhydryl Compounds	158-163	monoamine oxidase A	Rattus norvegicus	89-106
10582588-3	1999	We describe a general mechanism whereby the enzymatic metabolism of neurotransmitters by monoamine oxidase (MAO) damages mitochondria, altering their protein thiol status and suppressing respiration.	Sulfhydryl Compounds	158-163	monoamine oxidase A	Rattus norvegicus	108-111
10557227-0	1999	In Organello and in Vivo Evidence of the Importance of the Regulatory Sulfhydryl/Disulfide System and Pyruvate for Alternative Oxidase Activity in Tobacco.	Sulfhydryl Compounds	70-80	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	115-134
10559209-5	1999	The relative stability of reduced MerP appears to be related to the lowered thiol pK(a) (5.5) of the Cys-17 side chain.	Sulfhydryl Compounds	76-81	mercuric transport protein periplasmic component MerP	Escherichia coli	34-38
10599834-1	1999	Regions of the hippocampal inward rectifier potassium channel Kir 2.3 that contact the aqueous environment were investigated by identification of native cysteine residues that confer sulfhydryl reagent sensitivity to the channel conductance.	Sulfhydryl Compounds	183-193	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	62-69
10527932-3	1999	Consistent with earlier reports that GH is sulphydryl-sensitive, we found that recombinant human GH is inhibited by iodoacetic acid, suggesting that at least one cysteine is important for activity [Rhee, Lindau-Shepard, Chave, Galivan and Ryan (1998) Mol.	Sulfhydryl Compounds	43-53	gamma-glutamyl hydrolase	Homo sapiens	37-39
10527932-3	1999	Consistent with earlier reports that GH is sulphydryl-sensitive, we found that recombinant human GH is inhibited by iodoacetic acid, suggesting that at least one cysteine is important for activity [Rhee, Lindau-Shepard, Chave, Galivan and Ryan (1998) Mol.	Sulfhydryl Compounds	43-53	gamma-glutamyl hydrolase	Homo sapiens	97-99
10569626-2	1999	Intracellular redox homeostasis is regulated by thiol-containing molecules, such as glutathione and thioredoxin.	Sulfhydryl Compounds	48-53	thioredoxin	Homo sapiens	100-111
10569638-0	1999	Myeloperoxidase-catalyzed redox-cycling of phenol promotes lipid peroxidation and thiol oxidation in HL-60 cells.	Sulfhydryl Compounds	82-87	myeloperoxidase	Homo sapiens	0-15
10545483-9	1999	Resting peripheral blood T cells that express GGT have higher levels of intracellular thiols than those that do not.	Sulfhydryl Compounds	86-92	inactive glutathione hydrolase 2	Homo sapiens	46-49
10637766-6	1999	Although all PTPs have three-dimensional active-site structures very similar to each other and also have identical reaction mechanisms, the thiol group contained in the active site of low-M(r) PTP seems to have lower reactivity than that of other PTPs in the protein thiolation reaction.	Sulfhydryl Compounds	140-145	protein tyrosine phosphatase receptor type U	Homo sapiens	13-16
10557236-4	1999	The correlation between thiol tripeptides and the activities of glutathione synthetase (GSHS) and homoglutathione synthetase (hGSHS) in the nodules of eight legumes, and the contrasting thiol contents and activities in alfalfa (Medicago sativa) leaves (98% hGSH, 100% hGSHS) and nodules (72% GSH, 80% GSHS) indicated that the distribution of GSH and hGSH is determined by specific synthetases.	Sulfhydryl Compounds	24-29	glutathione synthetase	Homo sapiens	88-92
10531375-2	1999	We show that cadmium, a metal that binds thiols with high affinity and substitutes for zinc in the cysteinyl clusters of many proteins, inhibits the binding of recombinant, purified murine p53 to DNA.	Sulfhydryl Compounds	41-47	transformation related protein 53, pseudogene	Mus musculus	189-192
10529246-11	1999	Comparing the regions of BHMT amino acid sequence surrounding these Cys residues with similar amino acid sequences retrievable from protein databases, we have identified the following motif: G[ILV]NCX(20,100)[ALV]X(2)[ILV]GGCCX(3)PX(2)I, which we propose to be a signature for a family of zinc-dependent methyltransferases that utilize thiols or selenols as methyl acceptors.	Sulfhydryl Compounds	336-342	betaine--homocysteine S-methyltransferase	Homo sapiens	25-29
10556685-1	1999	Ambroxol (100 microM and 1 mM) and the thiols (all 1 mM), glutathione, tiopronin and cysteine, significantly attenuated the myeloperoxidase, H(2)O(2) and Cl(-) system-caused destruction of alpha(1)-antiproteinase and the HOCl-induced destruction of collagen, whereas they did not affect the elastase-induced destruction of collagen.	Sulfhydryl Compounds	39-45	myeloperoxidase	Homo sapiens	124-139
10556685-1	1999	Ambroxol (100 microM and 1 mM) and the thiols (all 1 mM), glutathione, tiopronin and cysteine, significantly attenuated the myeloperoxidase, H(2)O(2) and Cl(-) system-caused destruction of alpha(1)-antiproteinase and the HOCl-induced destruction of collagen, whereas they did not affect the elastase-induced destruction of collagen.	Sulfhydryl Compounds	39-45	serpin family A member 1	Homo sapiens	189-212
10521264-8	1999	Prior inhibition of cathepsin K by the active site thiol-modifying inhibitor E-64 blocked the modification by GSNO, indicating that the glutathione adduct is likely formed at the active site cysteine.	Sulfhydryl Compounds	51-56	cathepsin K	Cricetulus griseus	20-31
10514471-12	1999	HsPMP20 exerted an inhibitory effect on the inactivation of glutamine synthetase in the thiol metal-catalyzed oxidation system but not in the nonthiol metal-catalyzed oxidation system, suggesting that HsPMP20 possesses thiol-specific antioxidant activity.	Sulfhydryl Compounds	88-93	glutamate-ammonia ligase	Homo sapiens	60-80
23604425-7	1999	However, increasing the thiol concentration dramatically attenuated EGF receptor signaling in hepatocytes from both young and old animals.	Sulfhydryl Compounds	24-29	epidermal growth factor	Rattus norvegicus	68-71
10529181-2	1999	An attractive mechanism was proposed based on that of thymidylate synthase, in which the thiol(ate) group of a cysteine side chain serves as the nucleophile in a Michael addition to C6 of the isomerized uridine.	Sulfhydryl Compounds	89-94	thymidylate synthetase	Homo sapiens	54-74
10524225-6	1999	TIMP-1 induction by homocysteine appears to be mediated by its thiol group.	Sulfhydryl Compounds	63-68	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	0-6
10516189-4	1999	Of the thiol enzymes we investigated, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was particularly susceptible to inactivation, creatine kinase was moderately susceptible, and lactate dehydrogenase was unaffected by HOCl at the concentrations used.	Sulfhydryl Compounds	7-12	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	38-78
10516189-4	1999	Of the thiol enzymes we investigated, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was particularly susceptible to inactivation, creatine kinase was moderately susceptible, and lactate dehydrogenase was unaffected by HOCl at the concentrations used.	Sulfhydryl Compounds	7-12	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	80-85
10525268-4	1999	In vitro studies, however, showed that TDI avidly forms bis adducts with glutathione (GSH) and that these adducts transfer monoisocyanato-monoglutathionyl-TDI to a sulfhydryl-containing peptide.	Sulfhydryl Compounds	164-174	TLX1 neighbor	Homo sapiens	39-42
10525268-6	1999	Using an electron paramagnetic resonance spectrometric (EPR) method, we established that the level of thiol-dependent quenching of phenoxyl radicals of etoposide was decreased &gt;40% in pulmonary tissue of mice that received TDI intrabronchially.	Sulfhydryl Compounds	102-107	TLX1 neighbor	Homo sapiens	226-229
10525268-7	1999	Similarly, HBE cells exposed to 100 ppb TDI vapor experienced a &gt;30% reduction in thiol levels as determined with a thiol-specific fluorescent probe (ThioGlo 1).	Sulfhydryl Compounds	85-90	TLX1 neighbor	Homo sapiens	40-43
10525268-7	1999	Similarly, HBE cells exposed to 100 ppb TDI vapor experienced a &gt;30% reduction in thiol levels as determined with a thiol-specific fluorescent probe (ThioGlo 1).	Sulfhydryl Compounds	119-124	TLX1 neighbor	Homo sapiens	40-43
10525268-11	1999	This rapid reaction leading to formation of S-glutathionyl adducts of TDI suggests the importance of cellular thiols in TDI-induced pulmonary disease.	Sulfhydryl Compounds	110-116	TLX1 neighbor	Homo sapiens	70-73
10525268-11	1999	This rapid reaction leading to formation of S-glutathionyl adducts of TDI suggests the importance of cellular thiols in TDI-induced pulmonary disease.	Sulfhydryl Compounds	110-116	TLX1 neighbor	Homo sapiens	120-123
10480920-5	1999	First, formation of heavy metal- or CP-catalyzed RS-NO was examined with physiologically relevant concentrations of NO and various thiol compounds (RSH) such as glutathione (GSH).	Sulfhydryl Compounds	131-136	ceruloplasmin	Homo sapiens	36-38
10507767-3	1999	We describe here a method for the direct cross-linking of sulphydryl-conjugated HMFG1 (anti-MUC1 mucin mAb) to streptavidin by sulphosuccinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate.	Sulfhydryl Compounds	58-68	mucin 1, cell surface associated	Homo sapiens	92-96
10488136-3	1999	Recently, activation of nuclear factor-kappaB (NF-kappaB) has been shown to be under oxidoreduction (redox) regulation controlled by thioredoxin (TRX), which is one of major endogenous redox-regulating molecules with thiol reducing activity.	Sulfhydryl Compounds	217-222	nuclear factor kappa B subunit 1	Homo sapiens	24-45
10488136-3	1999	Recently, activation of nuclear factor-kappaB (NF-kappaB) has been shown to be under oxidoreduction (redox) regulation controlled by thioredoxin (TRX), which is one of major endogenous redox-regulating molecules with thiol reducing activity.	Sulfhydryl Compounds	217-222	nuclear factor kappa B subunit 1	Homo sapiens	47-56
10488136-3	1999	Recently, activation of nuclear factor-kappaB (NF-kappaB) has been shown to be under oxidoreduction (redox) regulation controlled by thioredoxin (TRX), which is one of major endogenous redox-regulating molecules with thiol reducing activity.	Sulfhydryl Compounds	217-222	thioredoxin	Homo sapiens	133-144
10488136-3	1999	Recently, activation of nuclear factor-kappaB (NF-kappaB) has been shown to be under oxidoreduction (redox) regulation controlled by thioredoxin (TRX), which is one of major endogenous redox-regulating molecules with thiol reducing activity.	Sulfhydryl Compounds	217-222	thioredoxin	Homo sapiens	146-149
10480913-7	1999	The TSA1 (thiol-specific antioxidant) gene encodes thioredoxin peroxidase that can reduce peroxides by using thioredoxin as a reducing power.	Sulfhydryl Compounds	10-15	thioredoxin peroxidase TSA1	Saccharomyces cerevisiae S288C	4-8
10512622-1	1999	To determine if a thiol group called SH1 has an important role in myosin"s motor function, we made a mutant heavy meromyosin (HMM) without the thiol group and analyzed its properties.	Sulfhydryl Compounds	18-23	myosin, heavy chain 15	Gallus gallus	66-72
10498206-0	1999	Synthesis and SAR of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase.	Sulfhydryl Compounds	35-40	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	55-60
10498206-1	1999	Potent thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase have been synthesized employing a solid-phase Mitsunobu reaction as the key step.	Sulfhydryl Compounds	21-26	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	41-46
10469051-9	1999	Flow cytometric analysis by the mercury orange staining method showed that glutamine significantly enhanced intracellular non-protein thiols in PHA-stimulated CD4+, but not CD8+ lymphocyte subsets.	Sulfhydryl Compounds	134-140	CD4 molecule	Homo sapiens	159-162
10524282-2	1999	We have analyzed wild-type and variant TTRs by mass spectrometry and found that TTR preparations from all individuals demonstrated free TTR, TTR conjugated with thiol compounds and several minor components.	Sulfhydryl Compounds	161-166	transthyretin	Homo sapiens	80-83
10524282-2	1999	We have analyzed wild-type and variant TTRs by mass spectrometry and found that TTR preparations from all individuals demonstrated free TTR, TTR conjugated with thiol compounds and several minor components.	Sulfhydryl Compounds	161-166	transthyretin	Homo sapiens	80-83
10524283-0	1999	Impact of age and amyloidosis on thiol conjugation of transthyretin in hereditary transthyretin amyloidosis.	Sulfhydryl Compounds	33-38	transthyretin	Homo sapiens	54-67
10524283-2	1999	The aim of the present study was to investigate thiol conjugation of transthyretin and it"s relation to age and symptomatic amyloid disease in different populations of variant TTR carriers.	Sulfhydryl Compounds	48-53	transthyretin	Homo sapiens	69-82
10524283-2	1999	The aim of the present study was to investigate thiol conjugation of transthyretin and it"s relation to age and symptomatic amyloid disease in different populations of variant TTR carriers.	Sulfhydryl Compounds	48-53	transthyretin	Homo sapiens	176-179
10524283-7	1999	In summary: Thiol conjugation of TTR is dependent on age and presence of symptomatic amyloid disease.	Sulfhydryl Compounds	12-17	transthyretin	Homo sapiens	33-36
10524283-9	1999	Variant TTR is more susceptible to thiol conjugation than the wild type.	Sulfhydryl Compounds	35-40	transthyretin	Homo sapiens	8-11
10469622-8	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activities by TPA and calcium ionophores may play a general role in the epigenetic mechanism of tumor promotion via thiol redox control mechanisms.	Sulfhydryl Compounds	181-186	thioredoxin 1	Mus musculus	13-24
10469622-8	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activities by TPA and calcium ionophores may play a general role in the epigenetic mechanism of tumor promotion via thiol redox control mechanisms.	Sulfhydryl Compounds	181-186	peroxiredoxin 5	Mus musculus	26-47
10469622-8	1999	Induction of thioredoxin, thioredoxin reductase and glutaredoxin activities by TPA and calcium ionophores may play a general role in the epigenetic mechanism of tumor promotion via thiol redox control mechanisms.	Sulfhydryl Compounds	181-186	glutaredoxin	Mus musculus	52-64
10491137-7	1999	MBD1 has only two cysteine residues, which can exist as free thiol groups (reduced), as a disulphide bond (oxidized) or bound to a metal ion [e.g. Cu(I)-MBD1].	Sulfhydryl Compounds	61-66	methyl-CpG binding domain protein 1	Homo sapiens	0-4
10490284-3	1999	However, thiol metabolites generated at the cell surface during GGT activity can induce prooxidant reactions, leading to production of free radical oxidant species.	Sulfhydryl Compounds	9-14	inactive glutathione hydrolase 2	Homo sapiens	64-67
10463938-3	1999	To address this issue, we have analyzed the purified recombinant c-Jun DNA binding domain for redox-dependent thiol modifications and concomitant changes in DNA binding activity.	Sulfhydryl Compounds	110-115	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70
10490269-1	1999	The thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control.	Sulfhydryl Compounds	169-174	thioredoxin	Homo sapiens	4-15
10490269-1	1999	The thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control.	Sulfhydryl Compounds	169-174	thioredoxin	Homo sapiens	17-20
10462537-10	1999	2) Intracellular reductants, GSH and protein sulfhydryls (but not phospholipids), are involved in myeloperoxidase-catalyzed etoposide redox-cycling that oxidizes endogenous thiols; pretreatment of HL60 cells with a maleimide thiol reagent, ThioGlo1, prevents redox-cycling of etoposide-O(.)	Sulfhydryl Compounds	173-179	myeloperoxidase	Homo sapiens	98-113
10438469-0	1999	The reactivity of the gamma-aminobutyric acid transporter GAT-1 toward sulfhydryl reagents is conformationally sensitive.	Sulfhydryl Compounds	71-81	solute carrier family 6 member 1	Homo sapiens	58-63
10455185-6	1999	Irreversible inhibition of pro-ISG15 processing activity by thiol-specific alkylating agents and a pH rate dependence conforming to titration of a single group of pK(a) 8.1 indicate the 100-kDa enzyme is a thiol protease.	Sulfhydryl Compounds	60-65	ISG15 ubiquitin like modifier	Homo sapiens	31-36
10463612-1	1999	Thioredoxin (Trx) is a small redox-active protein that provides reducing equivalents for key cysteine residues of proteins through thiol-disulfide exchange, such as the transcription factor nuclear factor-kappaB (NF-kappaB).	Sulfhydryl Compounds	131-136	thioredoxin	Homo sapiens	0-11
10463612-1	1999	Thioredoxin (Trx) is a small redox-active protein that provides reducing equivalents for key cysteine residues of proteins through thiol-disulfide exchange, such as the transcription factor nuclear factor-kappaB (NF-kappaB).	Sulfhydryl Compounds	131-136	thioredoxin	Homo sapiens	13-16
10463612-1	1999	Thioredoxin (Trx) is a small redox-active protein that provides reducing equivalents for key cysteine residues of proteins through thiol-disulfide exchange, such as the transcription factor nuclear factor-kappaB (NF-kappaB).	Sulfhydryl Compounds	131-136	nuclear factor kappa B subunit 1	Homo sapiens	190-211
10463612-1	1999	Thioredoxin (Trx) is a small redox-active protein that provides reducing equivalents for key cysteine residues of proteins through thiol-disulfide exchange, such as the transcription factor nuclear factor-kappaB (NF-kappaB).	Sulfhydryl Compounds	131-136	nuclear factor kappa B subunit 1	Homo sapiens	213-222
10428967-5	1999	Thioredoxin was able to reduce oxidized RsrA, suggesting that sigma(R), RsrA and the thioredoxin system comprise a novel feedback homeostasis loop that senses and responds to changes in the intracellular thiol-disulfide redox balance.	Sulfhydryl Compounds	204-209	thioredoxin	Homo sapiens	0-11
10428967-5	1999	Thioredoxin was able to reduce oxidized RsrA, suggesting that sigma(R), RsrA and the thioredoxin system comprise a novel feedback homeostasis loop that senses and responds to changes in the intracellular thiol-disulfide redox balance.	Sulfhydryl Compounds	204-209	thioredoxin	Homo sapiens	85-96
10489538-2	1999	The cis-diiodo-Pt(IV) complexes were readily reduced by biological thiols such as L-cysteine, glutathione (GSH), and bovine serum albumin (BSA) at pH 6.9 and 37 degrees C; the kinetics of reduction were second-order with respect to thiol concentration.	Sulfhydryl Compounds	67-73	albumin	Homo sapiens	124-137
10489538-2	1999	The cis-diiodo-Pt(IV) complexes were readily reduced by biological thiols such as L-cysteine, glutathione (GSH), and bovine serum albumin (BSA) at pH 6.9 and 37 degrees C; the kinetics of reduction were second-order with respect to thiol concentration.	Sulfhydryl Compounds	67-72	albumin	Homo sapiens	124-137
10668648-8	1999	The results suggest that NO and hydroperoxide inhibit glucose-stimulated insulin release by perturbing Ca2+ fluxes and probably acting through S-nitrosylation (NO) or oxidation (hydroperoxide) of thiol groups critical to the secretory process.	Sulfhydryl Compounds	196-201	insulin	Homo sapiens	73-80
10428497-6	1999	It was suggested that the active moiety of dinitrosyl iron complexes as inductors of heat shock protein synthesis is represented by their Fe+(NO+)2 groups which move to thiol groups of the proteins participating in the initiation of heat shock protein synthesis.	Sulfhydryl Compounds	169-174	selenoprotein K	Rattus norvegicus	85-103
10458774-5	1999	Cell treatment with the membrane impermeable, free-thiol reactive, 5,5"-dithiobis-2-nitrobenzoic acid enhanced cell surface CD4 dimers and tetramers.	Sulfhydryl Compounds	51-56	CD4 molecule	Homo sapiens	124-127
10458774-7	1999	Oligomerization of rCD4 by glutathione and thioredoxin indicates that thiol exchange interactions were responsible.	Sulfhydryl Compounds	70-75	Cd4 molecule	Rattus norvegicus	19-23
10458774-7	1999	Oligomerization of rCD4 by glutathione and thioredoxin indicates that thiol exchange interactions were responsible.	Sulfhydryl Compounds	70-75	thioredoxin	Homo sapiens	43-54
10451024-6	1999	GST-AA-NAT enzyme activity is also inhibited by reagents that are known biochemically to modify thiol groups (N-ethylmaleimide, NEM) and histidine residues (p-chloromercuribenzoate, NBS and diethyl pyrocarbonate, DEPC), suggesting the presence of essential cysteine and histidine moieties.	Sulfhydryl Compounds	96-101	aralkylamine N-acetyltransferase	Rattus norvegicus	4-10
10451024-8	1999	The conclusion is that the biochemical properties of rat recombinant AA-NAT is similar to the endogenous pineal and retinal AA-NAT with respect to the sensitivity to temperature, metal cations, as well as the thiol modification reagents.	Sulfhydryl Compounds	209-214	aralkylamine N-acetyltransferase	Rattus norvegicus	69-75
10415366-7	1999	After cross-linking and thiol-reduction, a distinct band corresponding to EP24.15 was significantly diminished under non-reducing conditions.	Sulfhydryl Compounds	24-29	thimet oligopeptidase 1	Mus musculus	74-81
10609640-6	1999	At high SDS concentrations, above 0.8 mM, the residual GroEL ATPase activity was less than 10% of the original activity, but the GroEL molecule maintained its native conformation (as indicated by the exposure of buried thiol groups, electrophoresis, and changes of CD spectra).	Sulfhydryl Compounds	219-224	heat shock protein family D (Hsp60) member 1	Homo sapiens	129-134
10419473-2	1999	Thioredoxin (TRX) is one of the major components of the thiol reducing system and plays multiple roles in cellular processes such as proliferation, apoptosis, and gene expression.	Sulfhydryl Compounds	56-61	thioredoxin	Homo sapiens	0-11
10419473-2	1999	Thioredoxin (TRX) is one of the major components of the thiol reducing system and plays multiple roles in cellular processes such as proliferation, apoptosis, and gene expression.	Sulfhydryl Compounds	56-61	thioredoxin	Homo sapiens	13-16
10428497-0	1999	Dinitrosyl iron complexes with thiol-containing ligands and S-nitroso-D,L-penicillamine as inductors of heat shock protein synthesis in H35 hepatoma cells.	Sulfhydryl Compounds	31-36	selenoprotein K	Rattus norvegicus	104-122
10428497-6	1999	It was suggested that the active moiety of dinitrosyl iron complexes as inductors of heat shock protein synthesis is represented by their Fe+(NO+)2 groups which move to thiol groups of the proteins participating in the initiation of heat shock protein synthesis.	Sulfhydryl Compounds	169-174	selenoprotein K	Rattus norvegicus	233-251
10391884-0	1999	Thiols mediate superoxide-dependent NADH modification of glyceraldehyde-3-phosphate dehydrogenase.	Sulfhydryl Compounds	0-6	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	57-97
10391884-7	1999	Lys-C digestion of GAPDH, followed by peptide isolation by high performance liquid chromatography, matrix-assisted laser desorption ionization time-of-flight analysis, and Edman sequencing, demonstrated that NADH attachment occurred at Cys-149, the active-site thiol.	Sulfhydryl Compounds	261-266	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	19-24
10391884-3	1999	We now demonstrate that in contrast to NO-mediated attachment of NAD, covalent attachment of NADH to GAPDH proceeds in the presence of low molecular weight thiols, independent of NO.	Sulfhydryl Compounds	156-162	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	101-106
10391884-9	1999	Thus, linkage of GAPDH to NADH, in contrast to NAD, occurs in the presence of thiol, is independent of NO, and is mediated by superoxide.	Sulfhydryl Compounds	78-83	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	17-22
10403526-2	1999	There are 16 free thiols, including 4 active site thiols, in a tetramer of GAPDH molecule.	Sulfhydryl Compounds	18-24	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	75-80
10385593-5	1999	Thiol depletion also induced leukotriene (LT) C4, LTD4, and LTE4 production and selective phosphorylation of p38-mitogen-activated protein kinase (MAPK) and its nuclear substrate ATF2.	Sulfhydryl Compounds	0-5	mitogen-activated protein kinase 14	Homo sapiens	109-145
10385593-5	1999	Thiol depletion also induced leukotriene (LT) C4, LTD4, and LTE4 production and selective phosphorylation of p38-mitogen-activated protein kinase (MAPK) and its nuclear substrate ATF2.	Sulfhydryl Compounds	0-5	mitogen-activated protein kinase 14	Homo sapiens	147-151
10385593-5	1999	Thiol depletion also induced leukotriene (LT) C4, LTD4, and LTE4 production and selective phosphorylation of p38-mitogen-activated protein kinase (MAPK) and its nuclear substrate ATF2.	Sulfhydryl Compounds	0-5	activating transcription factor 2	Homo sapiens	179-183
10385593-6	1999	LT production and p38-MAPK phosphorylation were required for induction of apoptosis because thiol depletion-induced apoptosis was completely blocked by the 5-lipoxygenase inhibitor AA861, the LT antagonists FPL55712 and ONO1078, and the p38-MAPK inhibitor SB203580.	Sulfhydryl Compounds	92-97	mitogen-activated protein kinase 14	Homo sapiens	18-21
10385593-6	1999	LT production and p38-MAPK phosphorylation were required for induction of apoptosis because thiol depletion-induced apoptosis was completely blocked by the 5-lipoxygenase inhibitor AA861, the LT antagonists FPL55712 and ONO1078, and the p38-MAPK inhibitor SB203580.	Sulfhydryl Compounds	92-97	mitogen-activated protein kinase 14	Homo sapiens	22-26
10385593-6	1999	LT production and p38-MAPK phosphorylation were required for induction of apoptosis because thiol depletion-induced apoptosis was completely blocked by the 5-lipoxygenase inhibitor AA861, the LT antagonists FPL55712 and ONO1078, and the p38-MAPK inhibitor SB203580.	Sulfhydryl Compounds	92-97	arachidonate 5-lipoxygenase	Homo sapiens	156-170
10385593-6	1999	LT production and p38-MAPK phosphorylation were required for induction of apoptosis because thiol depletion-induced apoptosis was completely blocked by the 5-lipoxygenase inhibitor AA861, the LT antagonists FPL55712 and ONO1078, and the p38-MAPK inhibitor SB203580.	Sulfhydryl Compounds	92-97	mitogen-activated protein kinase 14	Homo sapiens	237-240
10385593-6	1999	LT production and p38-MAPK phosphorylation were required for induction of apoptosis because thiol depletion-induced apoptosis was completely blocked by the 5-lipoxygenase inhibitor AA861, the LT antagonists FPL55712 and ONO1078, and the p38-MAPK inhibitor SB203580.	Sulfhydryl Compounds	92-97	mitogen-activated protein kinase 14	Homo sapiens	241-245
10385593-9	1999	Thus, thiol depletion induces apoptosis through an ordered pathway involving oxidant accumulation, LT production, and p38-MAPK activation.	Sulfhydryl Compounds	6-11	mitogen-activated protein kinase 14	Homo sapiens	118-121
10385593-9	1999	Thus, thiol depletion induces apoptosis through an ordered pathway involving oxidant accumulation, LT production, and p38-MAPK activation.	Sulfhydryl Compounds	6-11	mitogen-activated protein kinase 14	Homo sapiens	122-126
11228747-4	1999	In the present study, our aim was to investigate the role of exogenous thiol agents on ROS-induced PLD activation in conjunction with the role of cellular thiols--glutathione (GSH) and protein thiols--on PLD activation and protein tyrosine phosphorylation.	Sulfhydryl Compounds	71-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	99-102
10403526-0	1999	Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide.	Sulfhydryl Compounds	44-50	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	74-114
10403526-1	1999	The relationship between possible modifications of the thiol groups of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by nitric oxide (NO) and modified enzyme activity was examined.	Sulfhydryl Compounds	55-60	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	71-111
10403526-1	1999	The relationship between possible modifications of the thiol groups of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by nitric oxide (NO) and modified enzyme activity was examined.	Sulfhydryl Compounds	55-60	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	113-118
11228747-7	1999	Pretreatment of BPAECs with diamide or L-buthionine-(S,R)-sulfoximine (BSO), agents that lower intracellular GSH and thiols, enhanced PLD activity.	Sulfhydryl Compounds	117-123	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	134-137
11228747-10	1999	These results support the hypothesis that modulation of thiol-redox status (cellular nonprotein and protein thiols) may contribute to the regulation of ROS-induced protein tyrosine phosphorylation and PLD activation in vascular endothelium.	Sulfhydryl Compounds	56-61	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	201-204
11228747-10	1999	These results support the hypothesis that modulation of thiol-redox status (cellular nonprotein and protein thiols) may contribute to the regulation of ROS-induced protein tyrosine phosphorylation and PLD activation in vascular endothelium.	Sulfhydryl Compounds	108-114	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	201-204
10403526-2	1999	There are 16 free thiols, including 4 active site thiols, in a tetramer of GAPDH molecule.	Sulfhydryl Compounds	50-56	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	75-80
10403526-4	1999	After treatment for 30 min, free thiols were maximally decreased to 8-10 per GAPDH tetramer and enzyme activity was also inhibited to 5-10% of control activity.	Sulfhydryl Compounds	33-39	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	77-82
10403526-6	1999	Since similar results were obtained in the case of hydrogen peroxide (H2O2) treatment, which is known to oxidize the thiols, these effects of nitric oxide donors were probably due to modification of thiol groups present in a GAPDH molecule.	Sulfhydryl Compounds	117-123	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	225-230
10403526-6	1999	Since similar results were obtained in the case of hydrogen peroxide (H2O2) treatment, which is known to oxidize the thiols, these effects of nitric oxide donors were probably due to modification of thiol groups present in a GAPDH molecule.	Sulfhydryl Compounds	117-122	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	225-230
10403526-12	1999	These findings suggest that nitric oxide inhibits GAPDH activity by modifications of the thiols which are essential for this activity, and that the modification includes formation of sulfenic acid, which is not restored by DTT.	Sulfhydryl Compounds	89-95	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	50-55
10403526-13	1999	S-nitrosylation, which is one type of thiol modification by NO, occurred when GAPDH was treated with SNAP but not SNP.	Sulfhydryl Compounds	38-43	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	78-83
10403526-15	1999	It seems that SNAP nitrosylates the active site thiols of GAPDH to prevent these thiols from oxidizing to sulfenic acid.	Sulfhydryl Compounds	48-54	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	58-63
10403526-15	1999	It seems that SNAP nitrosylates the active site thiols of GAPDH to prevent these thiols from oxidizing to sulfenic acid.	Sulfhydryl Compounds	81-87	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	58-63
10406944-7	1999	Co-incubation of cells with homocysteine and the sulfhydryl inhibitor N-ethylmaleimide prevented the effect of homocysteine on ET-1 production, confirming a sulfhydryl-dependent mechanism.	Sulfhydryl Compounds	49-59	endothelin 1	Homo sapiens	127-131
10559898-2	1999	Here we show that the major pathway for oxidation in the yeast ER, defined by the protein Ero1, is responsible for the oxidation of both glutathione and protein thiols.	Sulfhydryl Compounds	161-167	ER oxidoreductin	Saccharomyces cerevisiae S288C	90-94
10489835-0	1999	Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by human alveolar macrophages.	Sulfhydryl Compounds	0-5	tumor necrosis factor	Homo sapiens	38-47
10489835-0	1999	Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by human alveolar macrophages.	Sulfhydryl Compounds	0-5	interleukin 6	Homo sapiens	49-53
10489835-0	1999	Thiol regulation of the production of TNF-alpha, IL-6 and IL-8 by human alveolar macrophages.	Sulfhydryl Compounds	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	58-62
10385654-9	1999	We investigated the thiol sensitivity of recombinant caspase-3 in vitro and observed that its activity was dependent on the presence of a reducing agent such as GSH, while GSSG attenuated proteolytic activity.	Sulfhydryl Compounds	20-25	caspase 3	Mus musculus	53-62
10385629-7	1999	Surprisingly, SCF and the Cdc53/Hrt1 subcomplex activate autoubiquitination of Cdc34 E2 enzyme by a mechanism that does not appear to require a reactive thiol.	Sulfhydryl Compounds	153-158	KIT ligand	Homo sapiens	14-17
10415548-8	1999	Incubation of SR membranes with an NO donor, PAPA/NO (a non-thiol compound that releases NO) at 200-500 microM completely prevented the t-BuOOH-dependent production of peroxyl radicals and formation of TBARS, and thus protected against oxidative inhibition of Ca2+ transport.	Sulfhydryl Compounds	60-65	pappalysin 1	Homo sapiens	45-49
10422834-2	1999	In the presence of denaturant and thiol catalyst, IGF-1 shuffles its native disulfide bonds and denatures to form a mixture of scrambled isomers.	Sulfhydryl Compounds	34-39	insulin like growth factor 1	Homo sapiens	50-55
10385629-7	1999	Surprisingly, SCF and the Cdc53/Hrt1 subcomplex activate autoubiquitination of Cdc34 E2 enzyme by a mechanism that does not appear to require a reactive thiol.	Sulfhydryl Compounds	153-158	ring-box 1	Homo sapiens	32-36
10422630-9	1999	We found that sulphydryl oxidising agents exert a differential inhibitory effect on hypoxia-induced versus DFO-induced Epo production, providing further evidence that multiple pathways of oxygen sensing exist.	Sulfhydryl Compounds	14-24	erythropoietin	Homo sapiens	119-122
10358090-9	1999	RyR3 was more steeply affected in the channel activity by sulfhydryl-oxidizing and -reducing reagents than RyR1, suggesting that the channel activity of RyR3 may be transformed more precipitously by the redox state.	Sulfhydryl Compounds	58-68	ryanodine receptor 3	Oryctolagus cuniculus	0-4
10358090-9	1999	RyR3 was more steeply affected in the channel activity by sulfhydryl-oxidizing and -reducing reagents than RyR1, suggesting that the channel activity of RyR3 may be transformed more precipitously by the redox state.	Sulfhydryl Compounds	58-68	ryanodine receptor 3	Oryctolagus cuniculus	153-157
10329674-5	1999	In addition, this segment seemed to be involved in B2 receptor activation, since (i) thiol modification of cysteine 94 partially suppressed B2 receptor activation, and (ii) site-directed antibodies to the connecting loop between membrane domains I and II were agonists.	Sulfhydryl Compounds	85-90	bradykinin receptor B2	Homo sapiens	51-62
10375435-9	1999	A comparative study of recombinant human lens TTase and GST (mu and pi) on their dethiolating abilities using lens crystallin-thiol mixed disulfides showed that the lens TTase is 60-70% more efficient in the dethiolation/repair process than GST.	Sulfhydryl Compounds	83-88	glutaredoxin	Homo sapiens	46-51
10375435-9	1999	A comparative study of recombinant human lens TTase and GST (mu and pi) on their dethiolating abilities using lens crystallin-thiol mixed disulfides showed that the lens TTase is 60-70% more efficient in the dethiolation/repair process than GST.	Sulfhydryl Compounds	83-88	glutathione S-transferase kappa 1	Homo sapiens	56-59
10375435-10	1999	When TTase and GST were tested in conjunction for the dethiolation of thiol mixed disulfides, there was no significant enhancement of dethiolase activity.	Sulfhydryl Compounds	56-61	glutaredoxin	Homo sapiens	5-10
10375435-10	1999	When TTase and GST were tested in conjunction for the dethiolation of thiol mixed disulfides, there was no significant enhancement of dethiolase activity.	Sulfhydryl Compounds	56-61	glutathione S-transferase kappa 1	Homo sapiens	15-18
10424456-6	1999	We demonstrate that the normal TTR monomer exists in different forms of variable stability and/or charge due to binding of sulfhydryls from plasma to the unique cysteine at position 10 of the primary structure as well as due to modification by treatment with an oxidant.	Sulfhydryl Compounds	123-134	transthyretin	Homo sapiens	31-34
10329674-5	1999	In addition, this segment seemed to be involved in B2 receptor activation, since (i) thiol modification of cysteine 94 partially suppressed B2 receptor activation, and (ii) site-directed antibodies to the connecting loop between membrane domains I and II were agonists.	Sulfhydryl Compounds	85-90	bradykinin receptor B2	Homo sapiens	140-151
10223910-1	1999	The introduction of reactive thiol groups in recombinant human tumor necrosis factor (TNF) alpha (rhTNF-alpha) by the reagent succinimidyl-S-acetylthioacetate resulted in the formation of a chemically stabilized rhTNF-alpha trimer (rhTNFalpha-AT; as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis).	Sulfhydryl Compounds	29-34	tumor necrosis factor	Homo sapiens	63-96
10231542-0	1999	Reversible change in thiol redox status of the insulin receptor alpha-subunit in intact cells.	Sulfhydryl Compounds	21-26	insulin	Homo sapiens	47-54
10231542-2	1999	Short-term treatment of intact cells expressing large numbers of IR with GSH or NAC led to a rapid and reversible reduction of IR alpha-subunit disulfides, without affecting the receptor beta-subunit thiol reactivity.	Sulfhydryl Compounds	200-205	insulin receptor	Homo sapiens	65-67
10231542-2	1999	Short-term treatment of intact cells expressing large numbers of IR with GSH or NAC led to a rapid and reversible reduction of IR alpha-subunit disulfides, without affecting the receptor beta-subunit thiol reactivity.	Sulfhydryl Compounds	200-205	X-linked Kx blood group	Homo sapiens	80-83
10231542-6	1999	No difference in insulin binding was observed in GSH-treated cells; however, ligand-mediated increases in IR autophosphorylation, tyrosine phosphorylation of cellular substrates, and dual phosphorylation of the downstream target mitogen-activated protein kinase were inhibited at concentrations of GSH (10 mM or greater) that yielded a significant increase in IR alpha-subunit thiol reactivity.	Sulfhydryl Compounds	377-382	insulin receptor	Homo sapiens	106-108
10227815-14	1999	These synergistic inhibitory effects of AUR and compounds with thiols on in vitro human B cell activation suggest the therapeutic efficacy of combinations of these compounds in RA.	Sulfhydryl Compounds	63-69	B cell linker	Homo sapiens	88-105
10495893-1	1999	The structure and stability in solution of the monomeric form of GroEL were studied by the methods of circular dichroism, binding of a hydrophobic probe, limited proteolysis, modification of thiol groups, sedimentation, and size-exclusion chromatography.	Sulfhydryl Compounds	191-196	heat shock protein family D (Hsp60) member 1	Homo sapiens	65-70
10404728-10	1999	This finding could be due to other cellular antioxidants, such as thioredoxin, ascorbic acid or tocopherols, maintaining redox status of these thiols.	Sulfhydryl Compounds	143-149	thioredoxin	Homo sapiens	66-77
10384960-0	1999	Regulation of cathepsin B activity by cysteine and related thiols.	Sulfhydryl Compounds	59-65	cathepsin B	Homo sapiens	14-25
10384960-1	1999	We studied the mode of regulation of the activity of mature cathepsin B (CB) by L-cysteine and some related thiols.	Sulfhydryl Compounds	108-114	cathepsin B	Homo sapiens	60-71
10384960-1	1999	We studied the mode of regulation of the activity of mature cathepsin B (CB) by L-cysteine and some related thiols.	Sulfhydryl Compounds	108-114	cathepsin B	Homo sapiens	73-75
10384960-5	1999	The capability of the thiols to overcome their own inhibitory effect on CB was dependent on the concentration of their thiolate anion (RS-).	Sulfhydryl Compounds	22-28	cathepsin B	Homo sapiens	72-74
10384960-11	1999	Taken together, the results indicate that the RSH form of Cys and related thiols inhibits the activity of CB while the RS- form of these thiols counteracts or reverses the inhibitory action of the RSH form.	Sulfhydryl Compounds	74-80	cathepsin B	Homo sapiens	106-108
10384960-12	1999	This previously unrecognized thiol-thiolate anion regulation mechanism might be involved in a dynamic regulation of CB activity in endosomes and lysosomes and at the sites of lysosome-driven pericellular proteolysis.	Sulfhydryl Compounds	29-34	cathepsin B	Homo sapiens	116-118
10456252-3	1999	Treatment with N-acetyl cysteine, i.e. a thiol-containing antioxidant, was found to increase the plasma albumin level and to ameliorate the loss of body cell mass in cancer patients and healthy individuals.	Sulfhydryl Compounds	41-46	albumin	Homo sapiens	104-111
10447715-6	1999	rTrx is required in a dose-dependent manner for development of efficient proteolysis, catalysed by thiol-dependent Cys-proteases, such as cathepsin B.	Sulfhydryl Compounds	99-104	thioredoxin 1	Rattus norvegicus	0-4
10447715-6	1999	rTrx is required in a dose-dependent manner for development of efficient proteolysis, catalysed by thiol-dependent Cys-proteases, such as cathepsin B.	Sulfhydryl Compounds	99-104	cathepsin B	Homo sapiens	138-149
10087468-1	1999	The therapeutic actions of captopril are facilitated by its sulfhydryl moiety which interacts with the metal (Zn2+) prosthetic groups of angiotensin-converting enzyme (ACE; EC 3.4.15.1).	Sulfhydryl Compounds	60-70	angiotensin I converting enzyme	Homo sapiens	137-166
10395072-4	1999	The effect of regucalcin to increase proteolytic activity was completely prevented in the presence of N-ethylmaleimide (5 mM), a modifying reagent of thiol groups.	Sulfhydryl Compounds	150-155	regucalcin	Rattus norvegicus	14-24
10087468-1	1999	The therapeutic actions of captopril are facilitated by its sulfhydryl moiety which interacts with the metal (Zn2+) prosthetic groups of angiotensin-converting enzyme (ACE; EC 3.4.15.1).	Sulfhydryl Compounds	60-70	angiotensin I converting enzyme	Homo sapiens	168-171
10092623-2	1999	In this study we show that nitrosonium tetrafluoroborate (BF4NO), a NO+ donor, modified the thiol groups of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by S-nitrosylation and caused enzyme inhibition.	Sulfhydryl Compounds	92-97	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	108-148
10213689-4	1999	Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active-site thiol.	Sulfhydryl Compounds	178-183	caspase 3	Homo sapiens	24-33
10198262-1	1999	In the present study, the effects of the thiol oxidising agent diamide upon the properties of rat brain beta1-adrenergic and human platelet serotonin2A receptor recognition sites have been investigated using [3H](-)CGP-12177 (in the presence of ICI-118551) and [3H]LSD as ligands.	Sulfhydryl Compounds	41-46	5-hydroxytryptamine receptor 2A	Homo sapiens	140-160
10209227-4	1999	Anti-CD34 immunoliposomes were prepared by the reaction of maleimide-derivatized My10 antibody with generated thiol groups at the periphery of the liposomes and efficiencies of nearly 100% were obtained.	Sulfhydryl Compounds	110-115	CD34 molecule	Homo sapiens	5-9
10092592-13	1999	The mechanism appears to be related to direct modification of thiol groups in the NF-kappaB subunits.	Sulfhydryl Compounds	62-67	nuclear factor kappa B subunit 1	Homo sapiens	82-91
10092623-2	1999	In this study we show that nitrosonium tetrafluoroborate (BF4NO), a NO+ donor, modified the thiol groups of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by S-nitrosylation and caused enzyme inhibition.	Sulfhydryl Compounds	92-97	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	150-155
10092623-4	1999	In contrast, the NO-releasing compound S-nitrosoglutathione (GSNO) promoted S-glutathionylation of a thiol group of GAPDH both in vitro and under cellular conditions.	Sulfhydryl Compounds	101-106	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	116-121
10085255-8	1999	A proteasome inhibitor and a thiol-reducing agent could mimic hypoxia by inducing HIF-1alpha in the nucleus, indicating that escape from proteolytic degradation is sufficient for accumulation and nuclear translocation of HIF-1alpha.	Sulfhydryl Compounds	29-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
10087161-7	1999	Incubation with thiols such as beta-ME or DTT also blocked the ability of the isothiazolone to inhibit p56(lck) kinase activity.	Sulfhydryl Compounds	16-22	cyclin dependent kinase like 2	Homo sapiens	103-106
10087161-7	1999	Incubation with thiols such as beta-ME or DTT also blocked the ability of the isothiazolone to inhibit p56(lck) kinase activity.	Sulfhydryl Compounds	16-22	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	107-110
10223197-8	1999	N-acetylcysteine, a thiol-containing antioxidant, decreased activation, further showing that vanadate-induced AP-1 activation involved redox reactions.	Sulfhydryl Compounds	20-25	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-114
10217408-6	1999	The activation of STATs by oxidized LDL was almost completely inhibited by the lipophilic antioxidant vitamin E, and partially antagonized by the hydrophilic thiol-containing compound N-acetylcysteine, suggesting that the oxidative stress induced by oxidized LDL is involved in the observed phenomenon.	Sulfhydryl Compounds	158-163	signal transducer and activator of transcription 1	Homo sapiens	18-23
10085010-1	1999	Pyolysin (PLO), the hemolytic exotoxin expressed by Arcanobacterium (Actinomyces) pyogenes, is a member of the thiol-activated cytolysin family of bacterial toxins.	Sulfhydryl Compounds	111-116	perforin 1 (pore forming protein)	Mus musculus	127-136
10099130-5	1999	The location of this residue was exploited for the rational design of bidentated inhibitors containing a maleinimide moiety at the P3 position for covalent linkage to the thiol group and a carboxy-terminal aldehyde group for hemiacetal formation with the Thr1 hydroxyl group of the active site.	Sulfhydryl Compounds	171-176	homoserine kinase	Saccharomyces cerevisiae S288C	255-259
10232828-3	1999	These reductions are inhibited by the thiol blocking agent N-ethylmaleimide and by the strong inhibitors of the thioredoxin reductase (TR) 2-chloro-2,4-nitrobenzene and 2,6-dichloroindophenol.	Sulfhydryl Compounds	38-43	peroxiredoxin 5	Homo sapiens	135-137
10085255-8	1999	A proteasome inhibitor and a thiol-reducing agent could mimic hypoxia by inducing HIF-1alpha in the nucleus, indicating that escape from proteolytic degradation is sufficient for accumulation and nuclear translocation of HIF-1alpha.	Sulfhydryl Compounds	29-34	hypoxia inducible factor 1 subunit alpha	Homo sapiens	221-231
10051436-3	1999	Attempts to characterize the signalling pathway from PDTC exposure to increases in the expression of the GCS catalytic and regulatory subunit genes demonstrated that induction by PDTC could be partially blocked by treatment with the thiol agent N-acetylcysteine and by the copper chelator bathocuproine disulphonic acid.	Sulfhydryl Compounds	233-238	glutamate-cysteine ligase catalytic subunit	Homo sapiens	105-108
10333174-10	1999	In addition, the thiol group of Cys1 side chain of the bioactive conformation points to the carboxylate moiety of Met4.	Sulfhydryl Compounds	17-22	cystin 1	Homo sapiens	32-36
10218902-6	1999	L-Cysteine, which is a thiol reagent that inhibits apomorphine autoxidation also prevented the formation of apomorphine-serum albumin adducts.	Sulfhydryl Compounds	23-28	albumin	Rattus norvegicus	120-133
10383197-12	1999	Structural comparison of the PDI b domain with thioredoxin and PDI a reveals several features important for thiol-disulfide exchange activity.	Sulfhydryl Compounds	108-113	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
10383197-12	1999	Structural comparison of the PDI b domain with thioredoxin and PDI a reveals several features important for thiol-disulfide exchange activity.	Sulfhydryl Compounds	108-113	thioredoxin	Homo sapiens	47-58
10383197-12	1999	Structural comparison of the PDI b domain with thioredoxin and PDI a reveals several features important for thiol-disulfide exchange activity.	Sulfhydryl Compounds	108-113	prolyl 4-hydroxylase subunit beta	Homo sapiens	63-66
10395457-0	1999	Nucleotide and Mg2+ induced conformational changes in GroEL can be detected by sulfhydryl labeling.	Sulfhydryl Compounds	79-89	mucin 7, secreted	Homo sapiens	15-18
10395457-0	1999	Nucleotide and Mg2+ induced conformational changes in GroEL can be detected by sulfhydryl labeling.	Sulfhydryl Compounds	79-89	heat shock protein family D (Hsp60) member 1	Homo sapiens	54-59
10097175-1	1999	Thioredoxin (TRX) plays important biological roles both in intra- and extracellular compartments, including in regulation of various intracellular molecules via thiol redox control.	Sulfhydryl Compounds	161-166	thioredoxin 1	Mus musculus	0-11
10097175-1	1999	Thioredoxin (TRX) plays important biological roles both in intra- and extracellular compartments, including in regulation of various intracellular molecules via thiol redox control.	Sulfhydryl Compounds	161-166	thioredoxin 1	Mus musculus	13-16
10037758-2	1999	By using a combination of introduced cysteine mutants and sulfhydryl-specific chemistry, we have mapped the topology of the human AE1 membrane domain.	Sulfhydryl Compounds	58-68	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	130-133
10360678-6	1999	In fact, efficient thiol modification of the SERCA1 was also observed after the exposure to peroxynitrite.	Sulfhydryl Compounds	19-24	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1	Rattus norvegicus	45-51
10080140-6	1999	PLA2 activity was estimated colorimetrically by determination of thiol release from the substrate, arachidonyl thio-PC.	Sulfhydryl Compounds	65-70	phospholipase A2 group IB	Rattus norvegicus	0-4
10080911-2	1999	Transcriptionally active genomic DNA fragments from Epo-treated cells and control cells are purified from inactive chromatin using mercury affinity chromatography, based on the mechanism that the thiol groups of histone H3 on transcriptionally active chromatin are exposed to the solvent and therefore are easily accessible.	Sulfhydryl Compounds	196-201	erythropoietin	Homo sapiens	52-55
10074082-10	1999	When a small thiol such as dithiothreitol was added to the medium, the rate of H2O2 decomposition in the DeltakatG mutant increased more than 10-fold, indicating that a thiol-specific peroxidase, for which thioredoxin may be the physiological electron donor, is present.	Sulfhydryl Compounds	13-18	thioredoxin	Homo sapiens	206-217
10218664-3	1999	Proteins that contain non-native modified thiols can become destablized such that they unfold into molten globule-like intermediates at or below 37 degrees C, relieving Hsf-1 negative regulation, and inducing Hsp transcription.	Sulfhydryl Compounds	42-48	heat shock transcription factor 1	Homo sapiens	169-174
10218664-3	1999	Proteins that contain non-native modified thiols can become destablized such that they unfold into molten globule-like intermediates at or below 37 degrees C, relieving Hsf-1 negative regulation, and inducing Hsp transcription.	Sulfhydryl Compounds	42-48	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	209-212
10078874-5	1999	In this study, a new sensitive fluorimetric assay for 5-OPase activity was established which is based on the derivatization of glutamate with o-phthaldialdehyde in the presence of thiols and subsequent separation of the products by HPLC.	Sulfhydryl Compounds	180-186	5-oxoprolinase, ATP-hydrolysing	Homo sapiens	54-61
9973469-5	1999	This CD16-induced FasL expression was suppressed by oxidative stress, including thiol deprivation or treatment with hydrogen peroxide (H2O2).	Sulfhydryl Compounds	80-85	Fc gamma receptor IIIa	Homo sapiens	5-9
9973469-5	1999	This CD16-induced FasL expression was suppressed by oxidative stress, including thiol deprivation or treatment with hydrogen peroxide (H2O2).	Sulfhydryl Compounds	80-85	Fas ligand	Homo sapiens	18-22
9973469-6	1999	Addition of thiol-reducing compounds, such as L-cystine, 2-ME, or N-acetyl cysteine, restored FasL expression.	Sulfhydryl Compounds	12-17	Fas ligand	Homo sapiens	94-98
9973469-11	1999	These results suggest that suppression of calcineurin and NFAT activation is a mechanism by which oxidative stress inhibits FasL induction in activated NK cells and further support the hypothesis that thiol-reducing compounds might be required for maintenance of optimal NK functions under physiologic oxidative conditions.	Sulfhydryl Compounds	201-206	Fas ligand	Homo sapiens	124-128
10193578-0	1999	Inactivation of myocardial dihydrolipoamide dehydrogenase by myeloperoxidase systems: effect of halides, nitrite and thiol compounds.	Sulfhydryl Compounds	117-122	dihydrolipoamide dehydrogenase	Equus caballus	27-57
10193578-0	1999	Inactivation of myocardial dihydrolipoamide dehydrogenase by myeloperoxidase systems: effect of halides, nitrite and thiol compounds.	Sulfhydryl Compounds	117-122	myeloperoxidase	Equus caballus	61-76
10219106-0	1999	Investigation of slow dynamics of the sulfhydryl in the solution and gel states of bovine serum albumin: A vector electron paramagnetic resonance study.	Sulfhydryl Compounds	38-48	albumin	Homo sapiens	90-103
9891011-0	1999	Redox control of exofacial protein thiols/disulfides by protein disulfide isomerase.	Sulfhydryl Compounds	35-41	prolyl 4-hydroxylase subunit beta	Homo sapiens	56-83
9891011-2	1999	We examined the consequence of over- or underexpression of PDI in HT1080 fibrosarcoma cells for the redox state of cell-surface protein thiols/disulfides.	Sulfhydryl Compounds	136-142	prolyl 4-hydroxylase subunit beta	Homo sapiens	59-62
9891011-6	1999	Using 5,5"-dithio-bis(2-nitrobenzoic acid) to measure surface protein thiols, a 41-50% increase in surface thiols was observed in PDI-overexpressing cells, whereas a 29-33% decrease was observed in underexpressing cells.	Sulfhydryl Compounds	70-76	prolyl 4-hydroxylase subunit beta	Homo sapiens	130-133
9891011-6	1999	Using 5,5"-dithio-bis(2-nitrobenzoic acid) to measure surface protein thiols, a 41-50% increase in surface thiols was observed in PDI-overexpressing cells, whereas a 29-33% decrease was observed in underexpressing cells.	Sulfhydryl Compounds	107-113	prolyl 4-hydroxylase subunit beta	Homo sapiens	130-133
9891011-7	1999	Surface thiol content was strongly correlated with cellular (r = 0.998) and secreted (r = 0.969) PDI levels.	Sulfhydryl Compounds	8-13	prolyl 4-hydroxylase subunit beta	Homo sapiens	97-100
9891011-11	1999	These findings indicated that secreted PDI was controlling the redox state of existing exofacial protein thiols or reactive disulfide bonds.	Sulfhydryl Compounds	105-111	prolyl 4-hydroxylase subunit beta	Homo sapiens	39-42
9973315-5	1999	Moreover, CD38 was reported to undergo a selective and extensive internalization through non clathrin-coated endocytotic vesicles upon incubating CD38(+) cells with either NAD+ or thiol compounds: these endocytotic vesicles can convert cytosolic NAD into cADPR despite an asymmetric unfavorable orientation that makes the active site of CD38 intravesicular.	Sulfhydryl Compounds	180-185	CD38 molecule	Homo sapiens	10-14
10025950-0	1999	Kinetics of oxidation of aliphatic and aromatic thiols by myeloperoxidase compounds I and II.	Sulfhydryl Compounds	48-54	myeloperoxidase	Homo sapiens	58-73
10025950-2	1999	Because most of the non-steroidal anti-inflammatory drugs and other drugs contain a thiol group, it is necessary to understand how these substrates are oxidized by MPO.	Sulfhydryl Compounds	84-89	myeloperoxidase	Homo sapiens	164-167
10352718-0	1999	Interconversion pathways of aldose reductase induced by thiol compounds.	Sulfhydryl Compounds	56-61	aldo-keto reductase family 1 member B	Homo sapiens	28-44
11233148-2	1999	It has been suggested that NO* and its congeners may exert effects on actin-myosin crossbridge cycling by modulating critical thiols on the myosin head.	Sulfhydryl Compounds	126-132	myosin heavy chain 14	Homo sapiens	76-82
9886919-5	1999	Alkylation of hyperreactive sulfhydryls (&lt;3% of the total sulfhydryls) on RyR1 with N-ethylmaleimide completely blocks oxidant-induced intersubunit cross-linking and inhibits Ca2+-free 125I-CaM but not Ca2+/125I-CaM binding.	Sulfhydryl Compounds	28-39	ryanodine receptor 1	Homo sapiens	77-81
9886919-5	1999	Alkylation of hyperreactive sulfhydryls (&lt;3% of the total sulfhydryls) on RyR1 with N-ethylmaleimide completely blocks oxidant-induced intersubunit cross-linking and inhibits Ca2+-free 125I-CaM but not Ca2+/125I-CaM binding.	Sulfhydryl Compounds	28-39	calmodulin 1	Homo sapiens	193-196
9886919-5	1999	Alkylation of hyperreactive sulfhydryls (&lt;3% of the total sulfhydryls) on RyR1 with N-ethylmaleimide completely blocks oxidant-induced intersubunit cross-linking and inhibits Ca2+-free 125I-CaM but not Ca2+/125I-CaM binding.	Sulfhydryl Compounds	28-39	calmodulin 1	Homo sapiens	215-218
9886919-5	1999	Alkylation of hyperreactive sulfhydryls (&lt;3% of the total sulfhydryls) on RyR1 with N-ethylmaleimide completely blocks oxidant-induced intersubunit cross-linking and inhibits Ca2+-free 125I-CaM but not Ca2+/125I-CaM binding.	Sulfhydryl Compounds	61-72	ryanodine receptor 1	Homo sapiens	77-81
9893958-2	1999	The amine residue of NH2-C3(BHam)2 was converted to a maleimide group by reaction with N-succinimidyl-6-maleimidohexanoate, and the conjugation product was coupled to thiol groups of a monoclonal antibody against osteogenic sarcoma (OST7, IgG1) pretreated with 2-iminothiolane to prepare C3(BHam)2-OST7.	Sulfhydryl Compounds	167-172	complement component 3	Mus musculus	25-34
9893958-2	1999	The amine residue of NH2-C3(BHam)2 was converted to a maleimide group by reaction with N-succinimidyl-6-maleimidohexanoate, and the conjugation product was coupled to thiol groups of a monoclonal antibody against osteogenic sarcoma (OST7, IgG1) pretreated with 2-iminothiolane to prepare C3(BHam)2-OST7.	Sulfhydryl Compounds	167-172	LOC105243590	Mus musculus	239-243
9893958-2	1999	The amine residue of NH2-C3(BHam)2 was converted to a maleimide group by reaction with N-succinimidyl-6-maleimidohexanoate, and the conjugation product was coupled to thiol groups of a monoclonal antibody against osteogenic sarcoma (OST7, IgG1) pretreated with 2-iminothiolane to prepare C3(BHam)2-OST7.	Sulfhydryl Compounds	167-172	complement component 3	Mus musculus	288-297
11233148-2	1999	It has been suggested that NO* and its congeners may exert effects on actin-myosin crossbridge cycling by modulating critical thiols on the myosin head.	Sulfhydryl Compounds	126-132	myosin heavy chain 14	Homo sapiens	140-146
11233149-7	1999	Interestingly, both GLA-LA and LA treatments corrected a diabetes-related decrease in the gastrocnemius muscle low-molecular-weight reduced thiols content.	Sulfhydryl Compounds	140-146	galactosidase, alpha	Rattus norvegicus	20-23
10609876-6	1999	Oxidative substrates, electron-transport inhibitors, glutathione and thiol-reactive agents but also caspase inhibitors modulate TNF-induced ROS production and imply the existence of a negative regulator of ROS production.	Sulfhydryl Compounds	69-74	tumor necrosis factor	Mus musculus	128-131
10609879-3	1999	Preincubation of the murine T cell line EL-4 and the human umbilical cord vein endothelial cell line ECV 304 with thiol modifying compounds like diamide, menadione or phenylarsine oxide inhibited the IL-1-induced phosphorylation of an endogenous substrate with a molecular mass of 60 kD.	Sulfhydryl Compounds	114-119	interleukin 1 alpha	Homo sapiens	200-204
11233154-0	1999	AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant.	Sulfhydryl Compounds	65-70	peroxiredoxin 6	Homo sapiens	0-4
10609879-4	1999	In the endothelial cell line, a second target of about 85 kD was phosphorylated after IL-1 stimulation, which was also inhibited by thiol modification.	Sulfhydryl Compounds	132-137	interleukin 1 alpha	Homo sapiens	86-90
10989667-5	1999	Binding of CyP-D is increased in response to oxidative stress and some thiol reagents which sensitize the mPT to [Ca2+].	Sulfhydryl Compounds	71-76	peptidylprolyl isomerase F	Homo sapiens	11-16
10609879-5	1999	These data suggest that IL-1 signal transduction depends on free thiols which might be targets for redox regulation not only in lymphocytes, but also in endothelial cells.	Sulfhydryl Compounds	65-71	interleukin 1 alpha	Homo sapiens	24-28
10989667-7	1999	This is antagonized by carboxyatractyloside (an inhibitor of the ANT) and by modification of specific thiol groups on the ANT by oxidative stress or thiol reagents; such treatments thus enhance the mPT.	Sulfhydryl Compounds	102-107	solute carrier family 25 member 6	Homo sapiens	122-125
11233154-0	1999	AOP2 (antioxidant protein 2): structure and function of a unique thiol-specific antioxidant.	Sulfhydryl Compounds	65-70	peroxiredoxin 6	Homo sapiens	6-27
10989667-7	1999	This is antagonized by carboxyatractyloside (an inhibitor of the ANT) and by modification of specific thiol groups on the ANT by oxidative stress or thiol reagents; such treatments thus enhance the mPT.	Sulfhydryl Compounds	149-154	solute carrier family 25 member 6	Homo sapiens	122-125
11233154-8	1999	Together, these data strongly suggest that AOP2 is a novel thiol-dependent antioxidant that functions to scavenge particular hydroperoxides in the cell and mediate specific signals.	Sulfhydryl Compounds	59-64	peroxiredoxin 6	Homo sapiens	43-47
10501908-0	1999	Modulation of apoptosis and enhancement of chemosensitivity by decreasing cellular thiols in a mouse B-cell lymphoma cell line that overexpresses bcl-2.	Sulfhydryl Compounds	83-89	B cell leukemia/lymphoma 2	Mus musculus	146-151
10501908-9	1999	This may be especially true for tumor cells that overexpress bcl-2, a gene that modifies cellular thiol status and conveys resistance to apoptosis.	Sulfhydryl Compounds	98-103	B cell leukemia/lymphoma 2	Mus musculus	61-66
9914505-7	1999	To investigate a contribution of these extra cysteines in mouse Rt6.1 to thiol dependency of Rt6.1 transferase activity, Cys-80 and Cys-201 of Rt6.1 were replaced with serine and phenylalanine, respectively, the corresponding residues of mouse Rt6.	Sulfhydryl Compounds	73-78	ADP-ribosyltransferase 2a	Mus musculus	64-69
10365774-0	1999	Reduction of endothelial cell related TGFbeta activity by thiols.	Sulfhydryl Compounds	58-64	transforming growth factor beta 1	Homo sapiens	38-45
10365774-2	1999	We have previously demonstrated that thiols inhibit the pro-oxidant effects of TGFbeta1 in bovine pulmonary artery endothelial cells (BPAEC).	Sulfhydryl Compounds	37-43	transforming growth factor beta 1	Bos taurus	79-87
10365774-8	1999	Lower doses of thiols (0.1-1 mM), that we have shown inhibit the antiproliferative and pro-oxidant effects of exogenous TGFbeta1 on BPAEC, had no direct effect on TGFbeta bioactivity.	Sulfhydryl Compounds	15-21	transforming growth factor beta 1	Homo sapiens	120-128
10365774-8	1999	Lower doses of thiols (0.1-1 mM), that we have shown inhibit the antiproliferative and pro-oxidant effects of exogenous TGFbeta1 on BPAEC, had no direct effect on TGFbeta bioactivity.	Sulfhydryl Compounds	15-21	transforming growth factor beta 1	Homo sapiens	120-127
10365774-9	1999	In summary, thiols are capable of reducing the effects of TGFbeta in biological systems through a direct effect on the TGFbeta molecule.	Sulfhydryl Compounds	12-18	transforming growth factor beta 1	Homo sapiens	58-65
9886834-3	1999	In the present study, we have examined the effect of sulfhydryl group(s) inactivation on receptor internalization and GH binding-protein (GHBP) generation from the human (h) and rabbit (rb) full-length GHR, as well as from hGHRtr and a mutant of the free extracellular cysteine (hGHRtr-C241A), expressed in Chinese hamster ovary (CHO) cells.	Sulfhydryl Compounds	53-63	growth hormone receptor	Oryctolagus cuniculus	202-205
9914505-0	1999	Mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase.	Sulfhydryl Compounds	17-22	ADP-ribosyltransferase 2a	Mus musculus	6-11
10365774-9	1999	In summary, thiols are capable of reducing the effects of TGFbeta in biological systems through a direct effect on the TGFbeta molecule.	Sulfhydryl Compounds	12-18	transforming growth factor beta 1	Homo sapiens	119-126
9914505-7	1999	To investigate a contribution of these extra cysteines in mouse Rt6.1 to thiol dependency of Rt6.1 transferase activity, Cys-80 and Cys-201 of Rt6.1 were replaced with serine and phenylalanine, respectively, the corresponding residues of mouse Rt6.	Sulfhydryl Compounds	73-78	ADP-ribosyltransferase 2a	Mus musculus	64-67
10365774-10	1999	However, this action appears to be dose-dependent, and at low doses (0.1-1 mM) thiols may also inhibit the actions of exogenous TGFbeta1 in cell culture through a mechanism involving the cellular redox status.	Sulfhydryl Compounds	79-85	transforming growth factor beta 1	Homo sapiens	128-136
9914505-7	1999	To investigate a contribution of these extra cysteines in mouse Rt6.1 to thiol dependency of Rt6.1 transferase activity, Cys-80 and Cys-201 of Rt6.1 were replaced with serine and phenylalanine, respectively, the corresponding residues of mouse Rt6.	Sulfhydryl Compounds	73-78	ADP-ribosyltransferase 2a	Mus musculus	93-98
9914505-7	1999	To investigate a contribution of these extra cysteines in mouse Rt6.1 to thiol dependency of Rt6.1 transferase activity, Cys-80 and Cys-201 of Rt6.1 were replaced with serine and phenylalanine, respectively, the corresponding residues of mouse Rt6.	Sulfhydryl Compounds	73-78	ADP-ribosyltransferase 2a	Mus musculus	93-96
9914505-9	1999	Transferase activity of the Phe-201 mutant of Rt6.1 lost thiol dependency while that of the Ser-80 mutant remained thiol-dependent.	Sulfhydryl Compounds	57-62	ADP-ribosyltransferase 2a	Mus musculus	46-51
9914505-9	1999	Transferase activity of the Phe-201 mutant of Rt6.1 lost thiol dependency while that of the Ser-80 mutant remained thiol-dependent.	Sulfhydryl Compounds	115-120	ADP-ribosyltransferase 2a	Mus musculus	46-51
9914505-10	1999	Thus, we conclude that mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase, and that Cys-201 confers thiol dependency on Rt6.1 transferase.	Sulfhydryl Compounds	40-45	ADP-ribosyltransferase 2a	Mus musculus	29-34
9914505-10	1999	Thus, we conclude that mouse Rt6.1 is a thiol-dependent arginine-specific ADP-ribosyltransferase, and that Cys-201 confers thiol dependency on Rt6.1 transferase.	Sulfhydryl Compounds	40-45	ADP-ribosyltransferase 2a	Mus musculus	29-32
10563854-4	1999	These changes resulted in a specific denatured beta-LG monomer, which covalently associated via the free thiol group.	Sulfhydryl Compounds	105-110	beta-lactoglobulin	Bos taurus	47-54
9851827-7	1998	Cysteines in recombinant p47(phox) were covalently labeled with a sulfhydryl-reactive, environmentally sensitive, fluorescent probe N, N"-dimethyl-N(iodoacetyl)-N"-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)ethyleneamine (IANBD).	Sulfhydryl Compounds	66-76	pleckstrin	Homo sapiens	25-28
12136202-6	1999	From these results a hypothesis is proposed that nitrite may be an EDRF modulator which controls the nitrosation level of reduced thiols in biological system.	Sulfhydryl Compounds	130-136	alpha hemoglobin stabilizing protein	Homo sapiens	67-71
9918826-1	1998	Glutathione (GSH) is an abundant and ubiquitous low-molecular-weight thiol which has proposed roles in many cellular processes including protection against the deleterious effects of reactive oxygen species.	Sulfhydryl Compounds	69-74	glutamate--cysteine ligase	Saccharomyces cerevisiae S288C	13-16
9852122-13	1998	It is possible that these motifs in mucins are engaged in the thiol-disulfide interchange reactions during the assembly of disulfide-bonded multimers of mucin.	Sulfhydryl Compounds	62-67	LOC100508689	Homo sapiens	36-41
9890191-4	1999	CCl4 induced a LDH release and decreased cellular thiols and polyamine levels.	Sulfhydryl Compounds	50-56	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
9921712-5	1999	In an effort to identify the class of enzyme directly mediating TNFR Type II (75 kDa) shedding, a spectrum of carboxyl- (e.g., aspartate), hydroxyl- (e.g., serine), thiol (e.g., cysteine), and metalo- (e.g., Ca2+, Mg2+) protease-inhibiting agents were evaluated.	Sulfhydryl Compounds	165-170	TNF receptor superfamily member 1A	Homo sapiens	64-68
9851830-9	1998	The remarkable reactivity of the critical thiol group in GAPDH (Cys-149) toward peroxynitrite, which is one order of magnitude higher than that of previously studied sulfhydryls, indicate that it may constitute a preferential intracellular target for peroxynitrite.	Sulfhydryl Compounds	42-47	glyceraldehyde-3-phosphate dehydrogenase	Oryctolagus cuniculus	57-62
9851827-7	1998	Cysteines in recombinant p47(phox) were covalently labeled with a sulfhydryl-reactive, environmentally sensitive, fluorescent probe N, N"-dimethyl-N(iodoacetyl)-N"-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl)ethyleneamine (IANBD).	Sulfhydryl Compounds	66-76	pleckstrin	Homo sapiens	29-33
9990323-2	1998	Among the P-450-reductases, ATR2 contrasted by its very low FMN affinity and required a thiol-reducing agent for efficient cofactor binding to the FMN-depleted enzyme.	Sulfhydryl Compounds	88-93	ATRX chromatin remodeler	Homo sapiens	28-32
9862698-7	1998	Caspase-3 activity in cell lysate precultured with anti-Fas Ab was suppressed dose dependently by diamide and restored by thiol-reducing agents, DTT or TRX.	Sulfhydryl Compounds	122-127	caspase 3	Homo sapiens	0-9
9920403-10	1998	Our results support a mechanism for optimal binding of IgA to SC, that can occur both in vitro and in vivo, in which a thiol disulfide interchange occurs between a free IgA thiol and a sensitive SC disulfide following the initial non-covalent interaction.	Sulfhydryl Compounds	119-124	CD79a molecule	Homo sapiens	55-58
9920403-10	1998	Our results support a mechanism for optimal binding of IgA to SC, that can occur both in vitro and in vivo, in which a thiol disulfide interchange occurs between a free IgA thiol and a sensitive SC disulfide following the initial non-covalent interaction.	Sulfhydryl Compounds	119-124	CD79a molecule	Homo sapiens	169-172
9806838-1	1998	The mouse Aop2 (antioxidant protein 2) cDNA recently cloned from liver and kidney is a member of the thiol-specific antioxidant gene family.	Sulfhydryl Compounds	101-106	peroxiredoxin 6	Mus musculus	10-14
9829991-9	1998	Because a physiological concentration of H2O2 produces enzyme inactivation and considering that the activity is restored by reduction with low molecular weight thiols, we suggest that oxidative stress conditions and other processes producing hydrogen peroxide regulate the LMW-PTP in the cell.	Sulfhydryl Compounds	160-166	acid phosphatase 1	Homo sapiens	273-280
9848873-0	1998	Inhibition of tumor necrosis factor-alpha- and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents.	Sulfhydryl Compounds	106-111	tumor necrosis factor	Homo sapiens	14-41
9848873-0	1998	Inhibition of tumor necrosis factor-alpha- and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents.	Sulfhydryl Compounds	106-111	interleukin 1 alpha	Homo sapiens	47-60
9848873-0	1998	Inhibition of tumor necrosis factor-alpha- and interleukin-1-induced endothelial E-selectin expression by thiol-modifying agents.	Sulfhydryl Compounds	106-111	selectin E	Homo sapiens	81-91
9848873-2	1998	Tumor necrosis factor-alpha (TNF-alpha)- and interleukin-1 (IL-1)-induced E-selectin expression was analyzed after pretreating human umbilical vein endothelial cells with different thiol-modifying agents, ie, diamide, phenylarsine oxide, N-ethylmaleimide, and diethyl maleate.	Sulfhydryl Compounds	181-186	selectin E	Homo sapiens	74-84
9836582-7	1998	In the presence of thiols [DTT, glutathione (GSH), or L-cysteine], *NO was rapidly lost from sGC regenerating the ferrous high-spin form of the heme.	Sulfhydryl Compounds	19-25	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	93-96
10224749-7	1998	The results show that the catalase activity decreases, the amount of MDA increases and the total amount of thiol groups is smaller in preeclamptic placentas.	Sulfhydryl Compounds	107-112	catalase	Homo sapiens	26-34
9806838-1	1998	The mouse Aop2 (antioxidant protein 2) cDNA recently cloned from liver and kidney is a member of the thiol-specific antioxidant gene family.	Sulfhydryl Compounds	101-106	peroxiredoxin 6	Mus musculus	16-37
9844746-5	1998	Our results underline the differences, in terms of oligomerization and reactivity towards thiols, between CD38/NAD+glycohydrolases depending on their origin.	Sulfhydryl Compounds	90-96	CD38 molecule	Bos taurus	106-110
29711132-2	1998	In the synthesis of [{Be(SPh)2 (py)(NH3 )}2 {[18]crown-6}] (1, py=pyridine) from [Be{N(SiMe3 )2 }2 ] and HSPh, the coordinated ammonia molecules (see the structure of 1 in the picture) are formed in a competing reaction between liberated hexamethyldisilazane and the thiol.	Sulfhydryl Compounds	267-272	ankyrin 1	Homo sapiens	25-30
9784193-5	1998	The method was tested using untransformed poplars and poplars in which foliar thiol contents have been enhanced by overexpression of gamma-glutamylcysteine synthetase.	Sulfhydryl Compounds	78-83	glutamate-cysteine ligase catalytic subunit	Homo sapiens	133-166
9788927-6	1998	Oocytes expressing a mutant cx46 with a cysteine in position 35 exhibited a membrane conductance sensitive to the thiol reagent maleimidobutyryl biocytin (MBB).	Sulfhydryl Compounds	114-119	gap junction protein alpha 3	Homo sapiens	28-32
9825739-7	1998	Incubation of BSP with selenite in the presence of a thiol, namely glutathione, cysteine or N-acetylcysteine (which convert selenite into nucleophilic products, i.e. the respective selenopersulfides and hydrogen selenide) resulted in product(s) chromatographically identical to the biliary selenium-containing BSP metabolite(s) of peak Y, irrespective of the nature of the thiol used.	Sulfhydryl Compounds	53-58	integrin-binding sialoprotein	Rattus norvegicus	14-17
9825739-7	1998	Incubation of BSP with selenite in the presence of a thiol, namely glutathione, cysteine or N-acetylcysteine (which convert selenite into nucleophilic products, i.e. the respective selenopersulfides and hydrogen selenide) resulted in product(s) chromatographically identical to the biliary selenium-containing BSP metabolite(s) of peak Y, irrespective of the nature of the thiol used.	Sulfhydryl Compounds	53-58	integrin-binding sialoprotein	Rattus norvegicus	310-313
9825739-7	1998	Incubation of BSP with selenite in the presence of a thiol, namely glutathione, cysteine or N-acetylcysteine (which convert selenite into nucleophilic products, i.e. the respective selenopersulfides and hydrogen selenide) resulted in product(s) chromatographically identical to the biliary selenium-containing BSP metabolite(s) of peak Y, irrespective of the nature of the thiol used.	Sulfhydryl Compounds	373-378	integrin-binding sialoprotein	Rattus norvegicus	14-17
9862285-3	1998	In these cytochrome P-450-dependent lipid peroxidation systems, pretreatment of microsome with trisulfide derivatives (cystine trisulfide and thiocyclam) significantly inhibited TBA-RS formation and oxygen consumption compared with disulfide or thiol analogs (cystine, nereistoxin, or cysteine).	Sulfhydryl Compounds	245-250	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	9-25
9794806-0	1998	Activation of dihydrofolate reductase following thiol modification involves a conformational change at the active site.	Sulfhydryl Compounds	48-53	dihydrofolate reductase	Gallus gallus	14-37
9794806-1	1998	Compared with the activation of dihydrofolate reductase (DHFR) by protein denaturants and inorganic salts, activation of the enzyme by thiol modification is relatively slow.	Sulfhydryl Compounds	135-140	dihydrofolate reductase	Gallus gallus	32-55
9794806-1	1998	Compared with the activation of dihydrofolate reductase (DHFR) by protein denaturants and inorganic salts, activation of the enzyme by thiol modification is relatively slow.	Sulfhydryl Compounds	135-140	dihydrofolate reductase	Gallus gallus	57-61
9794806-9	1998	The results indicate that the activation of DHFR by p-HMB is due to modification-induced conformational changes at its active site, rather than the modification of the thiol group itself, which is almost complete within the dead-time of the experiment.	Sulfhydryl Compounds	168-173	dihydrofolate reductase	Gallus gallus	44-48
9815178-2	1998	The resulting thiol-oligodeoxynucleotides were reacted with a maleimido-peptide carrying the c-myc tag-sequence.	Sulfhydryl Compounds	14-19	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	93-98
9876928-8	1998	Computer analysis of possible interactions involving Cys121 in a three-dimensional structure of beta-lactoglobulin revealed that the thiol group is too far away from neighboring residues to form side-chain hydrogen bonds.	Sulfhydryl Compounds	133-138	beta-lactoglobulin	Bos taurus	96-114
9839241-2	1998	kappa-Casein is also involved in thiol-catalyzed disulfide interchange reactions with the whey proteins during heat treatments and, after rennet cleavage, in the facilitation of micelle coagulation.	Sulfhydryl Compounds	33-38	casein kappa	Homo sapiens	0-12
9774716-0	1998	Thiol/disulfide exchange between small heat shock protein 25 and glutathione.	Sulfhydryl Compounds	0-5	heat shock protein 1	Mus musculus	39-60
9789066-5	1998	The coupling of two such boron-rich oligophosphates to sulfhydryls introduced to the CH2 domain of a chimeric IgG3 has been demonstrated.	Sulfhydryl Compounds	55-66	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	110-114
9821018-12	1998	Oxidation of these thiol groups in GR would thus not lead to impairment of GR activity.	Sulfhydryl Compounds	19-24	glutathione-disulfide reductase	Homo sapiens	35-37
9788899-8	1998	Further, PLD activation by ROS was attenuated by N-acetylcysteine, indicating that intracellular thiol status is critical to ROS-mediated signal transduction.	Sulfhydryl Compounds	97-102	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	9-12
9801064-3	1998	In the present study, we found the 28 kDa protein to have thiol-dependent antioxidant activity, thereby protecting radical-sensitive proteins such as glutamine synthetase and hemoglobin from oxidative modification caused by thiol-dependent metal ion-catalyzed oxidation system.	Sulfhydryl Compounds	58-63	glutamate-ammonia ligase	Rattus norvegicus	150-170
9801064-3	1998	In the present study, we found the 28 kDa protein to have thiol-dependent antioxidant activity, thereby protecting radical-sensitive proteins such as glutamine synthetase and hemoglobin from oxidative modification caused by thiol-dependent metal ion-catalyzed oxidation system.	Sulfhydryl Compounds	224-229	glutamate-ammonia ligase	Rattus norvegicus	150-170
9755242-5	1998	In MAT I, S-nitrosylation of 1 thiol residue per subunit was associated with a marked inactivation of the enzyme (about 70%) that was reversed by glutathione (GSH).	Sulfhydryl Compounds	31-36	methionine adenosyltransferase 1A	Homo sapiens	3-6
9755242-6	1998	In MAT III, S-nitrosylation of 3 thiol residues per subunit led to a similar inactivation of the enzyme, which was also reversed by GSH.	Sulfhydryl Compounds	33-38	methionine adenosyltransferase 1A	Homo sapiens	3-6
9724539-2	1998	With the exception of bovine cardiac TnT, all known vertebrate TnT isoforms lack a thiol group, a property which makes the wild-type proteins unsuitable as cross-linking substrate.	Sulfhydryl Compounds	83-88	troponin T1, slow skeletal type	Homo sapiens	63-66
9721197-13	1998	We also examined the modifying effects of alamethicin and histone II-A on the sensitivity of Glc-6-Pase activities to inhibition by N-bromoacetylethanolamine phosphate (BAEP) and 3-mercaptopicolinate (3-MP), both thiol-directed reagents.	Sulfhydryl Compounds	213-218	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	93-103
9932650-0	1998	The sulfonylurea-inhibited NADH oxidase activity of HeLa cell plasma membranes has properties of a protein disulfide-thiol oxidoreductase with protein disulfide-thiol interchange activity.	Sulfhydryl Compounds	117-122	thioredoxin reductase 1	Homo sapiens	123-137
9810262-6	1998	However, treatment with sulphydryl (SH) compounds such as L-cysteine, dithiothreitol, and 2-mercaptoethanol abrogated the inhibitory effect of cynaropicrin on TNF-alpha production.	Sulfhydryl Compounds	24-34	tumor necrosis factor	Mus musculus	159-168
9810262-6	1998	However, treatment with sulphydryl (SH) compounds such as L-cysteine, dithiothreitol, and 2-mercaptoethanol abrogated the inhibitory effect of cynaropicrin on TNF-alpha production.	Sulfhydryl Compounds	36-38	tumor necrosis factor	Mus musculus	159-168
9756990-1	1998	Mouse-liver gamma-glutamyl hydrolase (GH) is a lysosomal endopeptidase with an acid pH optimum that is activated by sulfhydryl compounds and preferentially hydrolyzes the most proximal gamma-glutamyl linkage of longer chain polyglutamates of folates and their analogues.	Sulfhydryl Compounds	116-136	gamma-glutamyl hydrolase	Mus musculus	12-36
9756990-1	1998	Mouse-liver gamma-glutamyl hydrolase (GH) is a lysosomal endopeptidase with an acid pH optimum that is activated by sulfhydryl compounds and preferentially hydrolyzes the most proximal gamma-glutamyl linkage of longer chain polyglutamates of folates and their analogues.	Sulfhydryl Compounds	116-136	gamma-glutamyl hydrolase	Mus musculus	38-40
9804394-2	1998	Data like pH optimum, stability, influence of thiol groups and effects of thiol proteinase inhibitors, lack of binding to Concanavalin A and lack of contribution to the fluorescence by other cathepsins indicate that cathepsin B is the enzyme measured.	Sulfhydryl Compounds	46-51	cathepsin B	Homo sapiens	216-227
9786425-3	1998	Thiol deprivation increased apoptosis in NK cells induced by anti-Fas mAb or Fas ligand-transfected cells, and pretreatment of cells with N-acetyl cysteine, which increased intracellular glutathione, partially inhibited the apoptosis and reversed the effect of thiol-deficient medium, suggesting that Fas-induced apoptosis in NK cells is also redox sensitive.	Sulfhydryl Compounds	0-5	Fas ligand	Homo sapiens	77-87
9703199-14	1998	In addition, parameters indicative of xenobiotic-induced oxidative alterations were found: a significant decrease in intraerythrocytic thiol levels was a result of all compounds that initiate MetHb formation, as also described for slowly reacting xenobiotics.	Sulfhydryl Compounds	135-140	hemoglobin subunit gamma 2	Homo sapiens	192-197
9786425-6	1998	Thiol deprivation increased CPP32 activation induced by Fas engagement, but not by ceramides.	Sulfhydryl Compounds	0-5	caspase 3	Homo sapiens	28-33
9795994-1	1998	Thiol-disulphide exchanges are involved in many important biological processes; they are normally regulated by the glutaredoxin and thioredoxin systems.	Sulfhydryl Compounds	0-5	thioredoxin	Mycolicibacterium smegmatis MC2 155	132-143
9733680-1	1998	The glucosamine-1-phosphate acetyltransferase activity but not the uridyltransferase activity of the bifunctional GlmU enzyme from Escherichia coli was lost when GlmU was stored in the absence of beta-mercaptoethanol or incubated with thiol-specific reagents.	Sulfhydryl Compounds	235-240	acetyltransferase	Escherichia coli	28-45
9714750-3	1998	This binding is enhanced by thiol modification of the ANT caused by oxidative stress or other thiol reagents.	Sulfhydryl Compounds	28-33	solute carrier family 25 member 6	Homo sapiens	54-57
9714750-3	1998	This binding is enhanced by thiol modification of the ANT caused by oxidative stress or other thiol reagents.	Sulfhydryl Compounds	94-99	solute carrier family 25 member 6	Homo sapiens	54-57
9714750-5	1998	Binding of ADP or ATP to a matrix site of the ANT antagonises this effect of Ca2+; modification of other ANT thiol groups inhibits ADP binding and sensitises the MPT to [Ca2+].	Sulfhydryl Compounds	109-114	solute carrier family 25 member 6	Homo sapiens	105-108
9745361-3	1998	Specific "redox-sensing" elements, consisting of cysteine residues, have been identified in the structures of at least three transporter subtypes (GLT1, GLAST and EAAC1) and shown to regulate transport rate via thiol-disulphide redox interconversion.	Sulfhydryl Compounds	211-216	solute carrier family 1 member 2	Homo sapiens	147-151
9749156-9	1998	To examine whether oxidation of thiol groups in the ACE molecule could be involved in the action of GRH, the effects of thiol reducing agents: mercaptoethanol and dithiotreitol (DTT) were investigated.	Sulfhydryl Compounds	32-37	angiotensin I converting enzyme	Homo sapiens	52-55
9749156-9	1998	To examine whether oxidation of thiol groups in the ACE molecule could be involved in the action of GRH, the effects of thiol reducing agents: mercaptoethanol and dithiotreitol (DTT) were investigated.	Sulfhydryl Compounds	32-37	gonadotropin releasing hormone 1	Homo sapiens	100-103
9877233-13	1998	In summary, our results suggest that the inhibitory effect of NO on carbachol-induced insulin release is not to any significant extent exerted on the IP3-Ca2+ messenger system but rather through S-nitrosylation of critical thiol-residues in protein kinase C and/or other secretion-regulatory thiol groups.	Sulfhydryl Compounds	223-228	insulin	Homo sapiens	86-93
9877233-13	1998	In summary, our results suggest that the inhibitory effect of NO on carbachol-induced insulin release is not to any significant extent exerted on the IP3-Ca2+ messenger system but rather through S-nitrosylation of critical thiol-residues in protein kinase C and/or other secretion-regulatory thiol groups.	Sulfhydryl Compounds	292-297	insulin	Homo sapiens	86-93
9739565-4	1998	HL80/6 showed several fold increase in surface hydrophobicity, with exposed two thiol groups, and 17% deamidation.	Sulfhydryl Compounds	80-85	transmembrane 4 L six family member 1	Homo sapiens	0-6
9677356-0	1998	Three thiol groups are important for the activity of the liver microsomal glucose-6-phosphatase system.	Sulfhydryl Compounds	6-11	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	74-95
9689064-2	1998	Binding of the cocaine analog, [3H]2-beta-carbomethoxy-3-beta-(4-fluorophenyl) tropane (CFT) to the dopamine transporter is sensitive to polar sulfhydryl-specific derivatives of methanethiosulfonate (MTS).	Sulfhydryl Compounds	143-153	solute carrier family 6 member 3	Homo sapiens	100-120
9767365-0	1998	Investigation into thiol conjugation of transthyretin in hereditary transthyretin amyloidosis.	Sulfhydryl Compounds	19-24	transthyretin	Homo sapiens	40-53
9767365-7	1998	CONCLUSION: The finding of a decreased ratio of unconjugated to conjugated TTR Met-30 in plasma samples from symptomatic TTR Met-30 carriers indicates that thiol conjugation of TTR could be involved in amyloid formation.	Sulfhydryl Compounds	156-161	transthyretin	Homo sapiens	75-78
9767365-7	1998	CONCLUSION: The finding of a decreased ratio of unconjugated to conjugated TTR Met-30 in plasma samples from symptomatic TTR Met-30 carriers indicates that thiol conjugation of TTR could be involved in amyloid formation.	Sulfhydryl Compounds	156-161	transthyretin	Homo sapiens	121-124
9767365-7	1998	CONCLUSION: The finding of a decreased ratio of unconjugated to conjugated TTR Met-30 in plasma samples from symptomatic TTR Met-30 carriers indicates that thiol conjugation of TTR could be involved in amyloid formation.	Sulfhydryl Compounds	156-161	transthyretin	Homo sapiens	121-124
9711996-7	1998	In conclusion, these findings indicate that the short-acting, sulfhydryl-containing ACE inhibitor captopril can elicit beneficial metabolic effects on the hyperinsulinemia, dyslipidemia, glucose intolerance, and insulin resistance of muscle glucose transport of the obese Zucker rat.	Sulfhydryl Compounds	62-72	angiotensin I converting enzyme	Rattus norvegicus	84-87
9677356-1	1998	Unusual behavior of one thiol located in the glucose-6-phosphate translocase.	Sulfhydryl Compounds	24-29	solute carrier family 37 member 4	Homo sapiens	45-76
9677356-4	1998	Three thiol groups are important for Glc-6-Pase system activity.	Sulfhydryl Compounds	6-11	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	37-47
9745361-3	1998	Specific "redox-sensing" elements, consisting of cysteine residues, have been identified in the structures of at least three transporter subtypes (GLT1, GLAST and EAAC1) and shown to regulate transport rate via thiol-disulphide redox interconversion.	Sulfhydryl Compounds	211-216	solute carrier family 1 member 3	Homo sapiens	153-158
9677356-9	1998	Two other thiols important for the Glc-6-Pase system activity are located in the Glc-6-P translocase and are more reactive than the one located in the catalytic subunit.	Sulfhydryl Compounds	10-16	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	35-45
9745361-3	1998	Specific "redox-sensing" elements, consisting of cysteine residues, have been identified in the structures of at least three transporter subtypes (GLT1, GLAST and EAAC1) and shown to regulate transport rate via thiol-disulphide redox interconversion.	Sulfhydryl Compounds	211-216	solute carrier family 1 member 1	Homo sapiens	163-168
9666107-7	1998	Further experiments indicated that the inhibition of nNOS by organomercurial occurred via thiol modification.	Sulfhydryl Compounds	90-95	nitric oxide synthase 1	Rattus norvegicus	53-57
9703976-1	1998	Protein disulfide isomerase (PDI), the product of the essential PDI1 gene of Saccharomyces cerevisiae catalyzes oxidization of thiols, reduction of disulfide bonds, and isomerization of disulfides.	Sulfhydryl Compounds	127-133	protein disulfide isomerase family A member 2	Homo sapiens	29-32
9703976-1	1998	Protein disulfide isomerase (PDI), the product of the essential PDI1 gene of Saccharomyces cerevisiae catalyzes oxidization of thiols, reduction of disulfide bonds, and isomerization of disulfides.	Sulfhydryl Compounds	127-133	protein disulfide isomerase PDI1	Saccharomyces cerevisiae S288C	64-68
9714567-0	1998	Thiol-linked peroxidase activity of human ceruloplasmin.	Sulfhydryl Compounds	0-5	ceruloplasmin	Homo sapiens	42-55
9714567-3	1998	However, when ascorbates were replaced with a thiol-reducing equivalent such as dithiothreitol, DNA strand breaks were significantly prevented by the same amount of ceruloplasmin.	Sulfhydryl Compounds	46-51	ceruloplasmin	Homo sapiens	165-178
9714567-6	1998	In conclusion, the removal of H2O2 by human ceruloplasmin is not simply stoichiometric but thiol-dependent.	Sulfhydryl Compounds	91-96	ceruloplasmin	Homo sapiens	44-57
9716391-11	1998	The ability to catalyze its own thiol labile ubiquitylation identified it as a member of the ubiquitin-activating enzyme family (E1).	Sulfhydryl Compounds	32-37	ubiquitin	Oryctolagus cuniculus	93-102
9714726-11	1998	Therefore, on the basis of these three different approaches, the present studies suggest that the thiol environment offered by glutathione (in vivo and in vitro studies) or dithiothreitol (in a cell-free system) is critical for the maintenance of GPAT activity.	Sulfhydryl Compounds	98-103	glycerol-3-phosphate acyltransferase, mitochondrial	Homo sapiens	247-251
9651343-8	1998	Much less enrichment of nascent repair patches is observed in the thiol-reactive fraction from XPC cells, which repair primarily the transcribed strand of active genes.	Sulfhydryl Compounds	66-71	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	95-98
9684877-3	1998	We now report that the production of thiols by macrophages is greatly enhanced when cells are cultured with lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha).	Sulfhydryl Compounds	37-43	tumor necrosis factor	Homo sapiens	136-163
9684877-3	1998	We now report that the production of thiols by macrophages is greatly enhanced when cells are cultured with lipopolysaccharide (LPS) or tumor necrosis factor-alpha (TNF-alpha).	Sulfhydryl Compounds	37-43	tumor necrosis factor	Homo sapiens	165-174
9698091-5	1998	Moreover, DNA-binding activity of the bacterially expressed DNA-binding domain of the glucocorticoid receptor was repressed by the thiol-oxidizing reagent diamide; EPC-K1 also counteracted this repressive effect of diamide.	Sulfhydryl Compounds	131-136	nuclear receptor subfamily 3 group C member 1	Homo sapiens	86-109
9703889-1	1998	Human metallothioneins (hMTs), are low molecular weight cysteine-rich proteins that constitute the majority of intracellular protein thiols.	Sulfhydryl Compounds	133-139	MLRL	Homo sapiens	24-28
9698086-7	1998	In contrast, thiol conjugates of acrolein did not inhibit ALDH-3 activity, but were substrates only for ALDH-1.	Sulfhydryl Compounds	13-18	aldehyde dehydrogenase 1 family member A1	Homo sapiens	104-110
9653033-9	1998	Thiol-modified wtMIF that was alkylated under oxidizing conditions was found to have full enzymatic activity, whereas alkylation of wtMIF under reducing conditions completely eliminated MIF-mediated redox activity.	Sulfhydryl Compounds	0-5	macrophage migration inhibitory factor	Homo sapiens	17-20
9667953-5	1998	Upon partial reduction of human growth hormone (hGH) with dithiothreitol, its C-terminal disulfide bond between residues 182 and 189 was cleaved and the nascent thiol groups were modified with [125I]ASDPE to yield [125I]ASET-hGH [1-(thio-hGH)-2-(3"-[125I]iodo-5"-azidosalicylamido)ethane].	Sulfhydryl Compounds	161-166	growth hormone 1	Homo sapiens	32-46
9671264-5	1998	Regucalcin-increased phosphatase activity was clearly decreased by N-ethylmaleimide, a modifying reagent of thiol(SH)-group, suggesting that regucalcin acts on the SH-group of the enzyme.	Sulfhydryl Compounds	108-113	regucalcin	Rattus norvegicus	0-10
9671264-5	1998	Regucalcin-increased phosphatase activity was clearly decreased by N-ethylmaleimide, a modifying reagent of thiol(SH)-group, suggesting that regucalcin acts on the SH-group of the enzyme.	Sulfhydryl Compounds	108-113	regucalcin	Rattus norvegicus	141-151
9692913-13	1998	Our results suggest that oxidized thiols on apoB may be essential for the induction of apoptosis by oxidized LDL in human macrophages.	Sulfhydryl Compounds	34-40	apolipoprotein B	Homo sapiens	44-48
10079387-1	1998	Cathepsin B (CB) is a thiol-stimulated protease implicated in cancer invasion and metastasis.	Sulfhydryl Compounds	22-27	cathepsin B	Homo sapiens	0-11
9721329-11	1998	NO also exerts a protective effects both in vivo and in vitro by blocking TNF-alpha-induced apoptosis and hepatotoxicity, in part by a thiol-dependent inhibition of caspase-3-like protease activity.	Sulfhydryl Compounds	135-140	tumor necrosis factor	Homo sapiens	74-83
9721335-9	1998	Recent findings suggest that the interactions with superoxide radicals, thiols, and metals (particularly with Fe2+) may be important not only in buffering excess NO produced by NOS-2, but also in channeling it from physiologically to pathophysiologically relevant targets.	Sulfhydryl Compounds	72-78	nitric oxide synthase 2	Homo sapiens	177-182
10079387-1	1998	Cathepsin B (CB) is a thiol-stimulated protease implicated in cancer invasion and metastasis.	Sulfhydryl Compounds	22-27	cathepsin B	Homo sapiens	13-15
9714292-6	1998	Among the thiol agents tested for their efficacy to modulate cellular redox status, N-acetyl-L-cysteine (NAC) and alpha-lipoic acid hold promise for clinical use.	Sulfhydryl Compounds	10-15	X-linked Kx blood group	Homo sapiens	105-108
9720880-1	1998	Trypanothione reductase (TR), a flavoprotein oxidoreductase central to the unique thiol-redox system that operates in trypanosomatid protozoa, has been proposed as a potential target for the chemotherapy of trypanosomatid infections.	Sulfhydryl Compounds	82-87	trypanothione reductase	Leishmania donovani	0-23
9720880-1	1998	Trypanothione reductase (TR), a flavoprotein oxidoreductase central to the unique thiol-redox system that operates in trypanosomatid protozoa, has been proposed as a potential target for the chemotherapy of trypanosomatid infections.	Sulfhydryl Compounds	82-87	trypanothione reductase	Leishmania donovani	25-27
9596687-4	1998	NAC was also shown to reduce the formation of dense cells and increase the available thiols in beta-actin.	Sulfhydryl Compounds	85-91	synuclein alpha	Homo sapiens	0-3
9596687-4	1998	NAC was also shown to reduce the formation of dense cells and increase the available thiols in beta-actin.	Sulfhydryl Compounds	85-91	POTE ankyrin domain family member F	Homo sapiens	95-105
9642155-1	1998	In this report the protein human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been examined to clarify the roles of (a) direct oxidation and (b) thiol-disulphide exchange (with glutathione disulphide) on the modification of its catalytic activity.	Sulfhydryl Compounds	153-158	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	33-73
9642155-1	1998	In this report the protein human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been examined to clarify the roles of (a) direct oxidation and (b) thiol-disulphide exchange (with glutathione disulphide) on the modification of its catalytic activity.	Sulfhydryl Compounds	153-158	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	75-80
9637924-3	1998	We show here that the thiol-dependent reductase ERp57 (also known as ER60 protease) is involved in MHC class I assembly.	Sulfhydryl Compounds	22-27	protein disulfide isomerase family A member 3	Homo sapiens	48-53
9637924-3	1998	We show here that the thiol-dependent reductase ERp57 (also known as ER60 protease) is involved in MHC class I assembly.	Sulfhydryl Compounds	22-27	protein disulfide isomerase family A member 3	Homo sapiens	69-73
9633610-4	1998	Catalase or dithiothreitol also prevents membrane permeabilization, suggesting the participation of membrane protein thiol group oxidation induced by reactive oxygen species.	Sulfhydryl Compounds	117-122	catalase	Rattus norvegicus	0-8
12671299-12	1998	The exact mechanisms by which MAPK and caspases are activated by these agents are currently unknown, but may involve oxidative modification of glutathione (GSH) and/or protein thiols, and/or generation of secondary messengers, ceramide and calcium, which further activate downstream events.	Sulfhydryl Compounds	176-182	mitogen-activated protein kinase 1	Homo sapiens	30-34
9672248-4	1998	Based on the chemical nature of inducers and on results reported from several studies, we hypothesized that inducers of the Hsp response may be generally capable of triggering oxidation of non-protein thiols, particularly glutathione.	Sulfhydryl Compounds	201-207	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	124-127
9672248-6	1998	Presumably, thiol adduction and cross-linking would affect the structure of proteins involved, resulting in unfolding of a fraction of these proteins, causing heat shock factor (Hsf) activation.	Sulfhydryl Compounds	12-17	interleukin 6	Homo sapiens	159-176
9672248-6	1998	Presumably, thiol adduction and cross-linking would affect the structure of proteins involved, resulting in unfolding of a fraction of these proteins, causing heat shock factor (Hsf) activation.	Sulfhydryl Compounds	12-17	interleukin 6	Homo sapiens	178-181
9620673-1	1998	N-acetyl-L-cysteine (NAC), which is known as a multipotential agent; an antioxidant, a thiol reagent, or a tyrosine kinase inhibitor, inhibited N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced phospholipase D (PLD) activation in HL60 cells in a concentration-dependent manner (IC50 = 2 mM).	Sulfhydryl Compounds	87-92	X-linked Kx blood group	Homo sapiens	21-24
9620673-9	1998	However, thiol reagents, 1 mM 2,3-dimercapto-l-propanol (2,3-DMP), 1 mM dithiothreitol (DTT), and 2 mM cysteine also did not suppress protein tyrosine phosphorylation or PBut formation by fMLP.	Sulfhydryl Compounds	9-14	formyl peptide receptor 1	Homo sapiens	188-192
9720762-1	1998	In fura-2-labelled human platelets, the thiol oxidising agent diamide decreases the intracellular calcium response to thrombin and serotonin without affecting the basal calcium levels.	Sulfhydryl Compounds	40-45	coagulation factor II, thrombin	Homo sapiens	118-126
9633518-5	1998	This observation suggests that intracellular thiol redox status may be a critical determinant of TfR downmodulation induced by oxidative stress.	Sulfhydryl Compounds	45-50	transferrin receptor	Homo sapiens	97-100
9560306-0	1998	Thiol-independent interaction of protein disulphide isomerase with type X collagen during intra-cellular folding and assembly.	Sulfhydryl Compounds	0-5	prolyl 4-hydroxylase subunit beta	Homo sapiens	33-61
9871733-1	1998	The X-ray crystal structure of the src SH2 domain revealed the presence of a thiol residue (Cys 188) located proximal to the phosphotyrosine portion of a dipeptide ligand.	Sulfhydryl Compounds	77-82	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-38
9871733-3	1998	X-ray crystallographic and NMR examination of the complex formed between (1) and the src SH2 domain revealed a hemithioacetal formed by addition of the thiol to the aldehyde group with an additional stabilizing hydrogen bond between the acetal hydroxyl and a backbone carbonyl.	Sulfhydryl Compounds	152-157	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	85-88
9699794-15	1998	Organomercurial thiol reagents, such as mersalyl acid, inhibit MCT1 but not MCT2.	Sulfhydryl Compounds	16-21	solute carrier family 16 member 1	Rattus norvegicus	63-67
9626593-5	1998	CCl4 also increased formation of thiobarbituric acid-reactive substances (TBARs) and decreased thiol group content.	Sulfhydryl Compounds	95-100	C-C motif chemokine ligand 4	Rattus norvegicus	0-4
9626570-6	1998	In these brain areas, the increase in HSP70 protein levels occurred in absence of significant changes of antioxidant enzyme activities and was correlated with a marked depletion of intracellular bound thiols and with a decreased susceptibility to lipid peroxidation.	Sulfhydryl Compounds	201-207	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	38-43
9548568-5	1998	On the other hand, when nuclei are treated with the sulfhydryl crosslinking reagent sodium tetrathionate, NM-associated CK2 increases severalfold.	Sulfhydryl Compounds	52-62	casein kinase 2 beta	Rattus norvegicus	120-123
9626570-7	1998	Lower levels of HSP70 induction were found in cortex and cerebellum and were associated to decreases in SOD and CAT enzyme activities, with a lower depletion of protein bound thiols and with an increased susceptibility to lipid peroxidation.	Sulfhydryl Compounds	175-181	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	16-21
9630353-23	1998	Additional treatment with GSNO failed to increase the degree of aggregation inhibition, suggesting that a common pathway of thiol modification might be utilized by both GSNO and CMPS to elicit cyclic GMP-independent inhibition of platelet aggregation.	Sulfhydryl Compounds	124-129	5'-nucleotidase, cytosolic II	Homo sapiens	200-203
9545232-2	1998	Using peptide mapping by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to identify a new component, we now introduce a third molecular chaperone, the thiol-dependent reductase ER-60 (ERp57/GRP58/ERp61/HIP-70/Q2), into this process.	Sulfhydryl Compounds	174-179	protein disulfide isomerase associated 3	Mus musculus	207-212
9692856-2	1998	To develop a highly specific assay for MSH, we capitalized on the selective binding of thiols to a maleimide residue linked to bovine serum albumin and employed affinity-purified polyclonal antibody and an enzyme-linked secondary antibody for detection.	Sulfhydryl Compounds	87-93	msh homeobox 2	Homo sapiens	39-42
9545232-2	1998	Using peptide mapping by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to identify a new component, we now introduce a third molecular chaperone, the thiol-dependent reductase ER-60 (ERp57/GRP58/ERp61/HIP-70/Q2), into this process.	Sulfhydryl Compounds	174-179	protein disulfide isomerase associated 3	Mus musculus	213-218
9545232-2	1998	Using peptide mapping by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry to identify a new component, we now introduce a third molecular chaperone, the thiol-dependent reductase ER-60 (ERp57/GRP58/ERp61/HIP-70/Q2), into this process.	Sulfhydryl Compounds	174-179	protein disulfide isomerase associated 3	Mus musculus	219-224
9548745-1	1998	Isoleucyl-tRNA synthetase (IleRS) catalyzes transfer of isoleucine from the enzyme-bound Ile-AMP and Ile-tRNA to the thiol group of coenzyme A, forming a thioester, Ile-S-CoA.	Sulfhydryl Compounds	117-122	isoleucyl-tRNA synthetase 1	Homo sapiens	0-25
9548745-1	1998	Isoleucyl-tRNA synthetase (IleRS) catalyzes transfer of isoleucine from the enzyme-bound Ile-AMP and Ile-tRNA to the thiol group of coenzyme A, forming a thioester, Ile-S-CoA.	Sulfhydryl Compounds	117-122	isoleucyl-tRNA synthetase 1	Homo sapiens	27-32
9545370-0	1998	Human T cell cyclophilin18 binds to thiol-specific antioxidant protein Aop1 and stimulates its activity.	Sulfhydryl Compounds	36-41	peroxiredoxin 3	Homo sapiens	71-75
9545370-5	1998	Abundant cytosolic hCyP18 binds to the thiol-specific antioxidant protein Aop1 and stimulates its enzymatic activity.	Sulfhydryl Compounds	39-44	peroxiredoxin 3	Homo sapiens	74-78
9508091-6	1998	The activity of GRD in situ in intact cells was estimated using the thiol-reactive fluorogenic probe ThioGlo-1, which is cell permeant and reacts rapidly with GSH to give a highly fluorescent adduct.	Sulfhydryl Compounds	68-73	glutathione-disulfide reductase	Homo sapiens	16-19
9605420-0	1998	Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers.	Sulfhydryl Compounds	138-143	nuclear factor kappa B subunit 1	Homo sapiens	14-35
9593640-6	1998	In other tissues, an enzyme, thioltransferase (TTase), has been shown to be responsible for thiol/disulfide regulation.	Sulfhydryl Compounds	29-34	glutaredoxin	Homo sapiens	47-52
9521769-1	1998	The oxidative regeneration pathways of two three-disulfide mutants of bovine pancreatic ribonuclease A (RNase A) missing the 65-72 disulfide bond, [C65S,C72S] and [C65A,C72A], have been studied by using oxidized dithiothreitol (DTTox) as an oxidizing agent and 2-aminoethylmethanethiosulfonate (AEMTS) as a thiol-blocking agent at 25 degrees C and pH 8.0.	Sulfhydryl Compounds	307-312	ribonuclease pancreatic	Bos taurus	104-111
9568911-2	1998	In a previous study we had shown that glutaminyl-tRNA synthetase labeled selectively in a nonessential sulfhydryl residue by an environment sensitive probe, acrylodan, monitors many of the conformational changes that occur upon substrate binding.	Sulfhydryl Compounds	103-113	glutaminyl-tRNA synthetase 1	Homo sapiens	38-64
9521781-8	1998	The catalytic mechanism involves novel S-based cluster chemistry to facilitate electron transfer to the active-site disulfide resulting in covalent attachment of the electron-transfer cysteine and generation of the free interchange cysteine that is required for the thiol-disulfide interchange reaction with thioredoxin.	Sulfhydryl Compounds	266-271	thioredoxin	Homo sapiens	308-319
9510200-0	1998	Thiol-mediated regulation of ICAM-1 expression in endotoxin-induced acute lung injury.	Sulfhydryl Compounds	0-5	intercellular adhesion molecule 1	Rattus norvegicus	29-35
9544201-10	1998	While a representative compound 15 was stable and unreactive toward glutathione (GSH) in buffer, the Mannich bases 15, 18, and 21 reacted with GSH in the presence of the pi isozyme of glutathione S-transferase, suggesting that thiol alkylation may be one mechanism by which cytotoxicity was exerted in vitro.	Sulfhydryl Compounds	227-232	hematopoietic prostaglandin D synthase	Mus musculus	184-209
9506966-11	1998	PGT-mediated uptake was ATP- and temperature-dependent, but not sodium-dependent, and was inhibited by disulfonic stilbenes, niflumic acid, and the thiol reactive anion MTSES (Na(2-sulfonatoethyl)methanethiosulfonate).	Sulfhydryl Compounds	148-153	solute carrier organic anion transporter family member 2A1	Homo sapiens	0-3
9551807-0	1998	Study of factors affecting the determination of total plasma 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate (SBD)-thiol derivatives by liquid chromatography.	Sulfhydryl Compounds	111-116	OXA1L mitochondrial inner membrane protein	Homo sapiens	77-82
9551807-2	1998	Essentially, this assay entails extracting specific thiols by plasma disulphide bond reduction, protein precipitation, sulphydryl compound derivatization with the thiol-specific fluorogenic reagent ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F), and subsequent separation with isocratic reversed-phase high-performance liquid chromatography.	Sulfhydryl Compounds	52-58	OXA1L mitochondrial inner membrane protein	Homo sapiens	223-228
9551807-2	1998	Essentially, this assay entails extracting specific thiols by plasma disulphide bond reduction, protein precipitation, sulphydryl compound derivatization with the thiol-specific fluorogenic reagent ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate (SBD-F), and subsequent separation with isocratic reversed-phase high-performance liquid chromatography.	Sulfhydryl Compounds	52-57	OXA1L mitochondrial inner membrane protein	Homo sapiens	223-228
9521863-2	1998	Recently we demonstrated the thiol antioxidant N-acetylcysteine (NAC) inhibits constitutive NF-kappa B/Rel activity and growth of vascular SMCs.	Sulfhydryl Compounds	29-34	nuclear factor kappa B subunit 1	Homo sapiens	92-102
9510200-10	1998	These data indicate the presence of a thiol-sensitive mechanism for modulating ICAM-1 gene expression and suggest a potential novel therapeutic strategy for diseases characterized by PMN-mediated tissue injury.	Sulfhydryl Compounds	38-43	intercellular adhesion molecule 1	Rattus norvegicus	79-85
9568738-2	1998	The pleiotropic actions exerted by angiotensin II (AngII) on the functionality of the vessel wall may have pro-atherosclerotic outcomes; evidence for an anti-atherosclerotic effect of ACE-Is has been presented and an antioxidant effect has been attributed to thiol-containing ACE-Is, like Captopril.	Sulfhydryl Compounds	259-264	angiotensin-converting enzyme	Oryctolagus cuniculus	184-187
9586959-10	1998	This suggests that TNCB might inhibit 5-lipoxygenase by alkylating thiol groups.	Sulfhydryl Compounds	67-72	arachidonate 5-lipoxygenase	Homo sapiens	38-52
9566515-2	1998	Here we report that filarial nematodes include the thioredoxin peroxidase/thiol-specific antioxidant (TPx/TSA) family of antioxidant proteins as part of their complex defense against radical-mediated damage.	Sulfhydryl Compounds	74-79	putative thioredoxin B0024.9, putative	Brugia malayi	51-62
9518260-0	1998	Thiol redox modulation of tumor necrosis factor-alpha responsiveness in cultured AIDS-related Kaposi"s sarcoma cells.	Sulfhydryl Compounds	0-5	tumor necrosis factor	Homo sapiens	26-53
9688212-3	1998	During the first reaction phase a stoichiometric amount of oxygen is consumed (1 mole oxygen per 4 moles thiol) with minimal .OH production.	Sulfhydryl Compounds	105-110	PER3 pseudogene 1	Homo sapiens	93-98
9518260-12	1998	Our data, which show that a perturbation in their cellular thiol redox status accentuates AIDS-KS cellular responsiveness to TNF-alpha, suggest a biochemical rationale for the recognized TNF-alpha AIDS-KS clinical correlation.	Sulfhydryl Compounds	59-64	tumor necrosis factor	Homo sapiens	125-134
9518260-10	1998	Subsequent thiol redox modulation studies showed that only the normal fibroblast cultures showed a potentiation of TNF-alpha-mediated MnSOD upregulation following GSH depletion.	Sulfhydryl Compounds	11-16	tumor necrosis factor	Homo sapiens	115-124
9518260-12	1998	Our data, which show that a perturbation in their cellular thiol redox status accentuates AIDS-KS cellular responsiveness to TNF-alpha, suggest a biochemical rationale for the recognized TNF-alpha AIDS-KS clinical correlation.	Sulfhydryl Compounds	59-64	tumor necrosis factor	Homo sapiens	187-196
9495836-2	1998	S 21402-1 [(2S)-2-[(2S,3R)-2-thiomethyl-3-phenylbutanamido] propionic acid] is a sulfhydryl-containing potent inhibitor of both NEP (Ki = 1.7 nM) and ACE (Ki = 4.5 nM).	Sulfhydryl Compounds	81-91	membrane metallo-endopeptidase	Rattus norvegicus	128-131
9495836-3	1998	S 21402-1 and the sulfhydryl-containing ACE inhibitor captopril were administered to rats by intraperitoneal injection (0, 0.3, 3, 30, 300 mg/kg).	Sulfhydryl Compounds	18-28	angiotensin I converting enzyme	Rattus norvegicus	40-43
9473277-0	1998	Matrix-assisted laser desorption/ionization mass spectrometry analysis and thiol-group determination of isoforms of bovine cytochrome c oxidase, a hydrophobic multisubunit membrane protein.	Sulfhydryl Compounds	75-80	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	123-143
9510335-7	1998	The ability to introduce the CTP-SH analogue enzymatically into RNA opens the way for new structure-function studies where the 2"-hydroxyl can be efficiently replaced by a thiol group.	Sulfhydryl Compounds	172-177	solute carrier family 25 member 1	Homo sapiens	29-32
9519879-0	1998	The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition.	Sulfhydryl Compounds	4-9	BCL2 apoptosis regulator	Homo sapiens	82-87
9519879-1	1998	In several different cell lines, Bcl-2 prevents the induction of apoptosis (DNA fragmentation, PARP cleavage, phosphatidylserine exposure) by the pro-oxidant ter-butylhydroperoxide (t-BHP) but has no cytoprotective effect when apoptosis is induced by the thiol crosslinking agent diazenedicarboxylic acid his 5N,N-dimethylamide (diamide).	Sulfhydryl Compounds	255-260	BCL2 apoptosis regulator	Homo sapiens	33-38
9518466-9	1998	Mass spectrometry and a chemical assay for free sulfhydryls indicated that the four cysteine residues of interleukin-13 are involved in two intramolecular disulfide bonds.	Sulfhydryl Compounds	48-59	interleukin 13	Homo sapiens	105-119
9473298-3	1998	Unlike the native enzyme, S-glutathionyl-modified ALR2 is unaffected by HNE, and can be easily reverted to the native form under thiol-reducing conditions.	Sulfhydryl Compounds	129-134	lens aldose reductase pseudogene	Bos taurus	50-54
9449305-7	1998	Mutants of a protease inhibitor, plasminogen activator inhibitor type-1 (PAI-1), containing one or two cysteine residues, were labeled with sulfhydryl specific derivatives of 4,4-difluoro-4-borata-3a-azonia-4a-aza-s-indacence (BODIPY).	Sulfhydryl Compounds	140-150	serpin family E member 1	Homo sapiens	33-71
9448306-4	1998	We imparted free sulfhydryl residues to a pool of erythropoietin monomer by chemical modification.	Sulfhydryl Compounds	17-27	erythropoietin	Homo sapiens	50-64
9477956-11	1998	If the sulfhydryl-specific reagent N-ethylmaleimide is included in the sample during preparation for electrophoresis or if Cys185 is changed to Ser, the two fragments do comigrate with full-length rhodopsin on SDS gels and, therefore, are connected by the native Cys110-Cys187 disulfide bond.	Sulfhydryl Compounds	7-17	rhodopsin	Homo sapiens	197-206
9476887-7	1998	Although AP lavage generally contained more non-thiol-dependent SP-A aggregates and low Mr isoforms, the two-dimensional immunochemical staining patterns varied between patients and right and left lung.	Sulfhydryl Compounds	48-53	surfactant protein A1	Homo sapiens	64-68
9468277-1	1998	Dithiothreitol (DTT) and other dithiol antioxidants with closely spaced thiol pairs strongly activate leukocyte function antigen-1 (LFA-1, alphaLbeta2 integrin) to bind intercellular adhesion molecule-1 (ICAM-1).	Sulfhydryl Compounds	33-38	integrin subunit alpha L	Homo sapiens	102-130
9468277-1	1998	Dithiothreitol (DTT) and other dithiol antioxidants with closely spaced thiol pairs strongly activate leukocyte function antigen-1 (LFA-1, alphaLbeta2 integrin) to bind intercellular adhesion molecule-1 (ICAM-1).	Sulfhydryl Compounds	33-38	integrin subunit alpha L	Homo sapiens	132-137
9468277-1	1998	Dithiothreitol (DTT) and other dithiol antioxidants with closely spaced thiol pairs strongly activate leukocyte function antigen-1 (LFA-1, alphaLbeta2 integrin) to bind intercellular adhesion molecule-1 (ICAM-1).	Sulfhydryl Compounds	33-38	intercellular adhesion molecule 1	Homo sapiens	169-202
9468277-1	1998	Dithiothreitol (DTT) and other dithiol antioxidants with closely spaced thiol pairs strongly activate leukocyte function antigen-1 (LFA-1, alphaLbeta2 integrin) to bind intercellular adhesion molecule-1 (ICAM-1).	Sulfhydryl Compounds	33-38	intercellular adhesion molecule 1	Homo sapiens	204-210
9468277-3	1998	Phenylarsine oxide (PAO), an oxidant selectively reactive with closely spaced pairs of thiol groups, inhibited LFA-1-dependent adhesion of human natural killer and HSB2 T leukemia cells to murine cells expressing human ICAM-1.	Sulfhydryl Compounds	87-92	integrin subunit alpha L	Homo sapiens	111-116
9454583-7	1998	Unfolded TIM monomers are susceptible to proteolytic digestion and thiol oxidation, while native TIM is resistant to both.	Sulfhydryl Compounds	67-72	triosephosphate isomerase	Oryctolagus cuniculus	9-12
9466906-2	1998	Previous studies have demonstrated that modification of Mu B with the sulfhydryl-specific reagent N-ethylmaleimide can selectively inhibit target DNA binding.	Sulfhydryl Compounds	70-80	ubiquitin like 3	Homo sapiens	56-60
9448725-0	1998	Inhibition of NF-kappa B binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: evidence of a thiol mechanism.	Sulfhydryl Compounds	114-119	nuclear factor kappa B subunit 1	Homo sapiens	14-24
9448725-1	1998	NF-kappa B binding to DNA in the presence of thiol-reactive metals has been explored in vitro.	Sulfhydryl Compounds	45-50	nuclear factor kappa B subunit 1	Homo sapiens	0-10
9466666-9	1998	The survival- and proliferation-inducing activity of thiol compounds in the presence of catalase, pyruvate and BCS was not associated with induction of BCL-2 or BAX.	Sulfhydryl Compounds	53-58	catalase	Mus musculus	88-96
9452441-6	1998	Peroxynitrite had no effect in the absence of GSH but significantly stimulated the enzyme in the presence of the thiol (3.45 +/- 0.60 micromol of cGMP x mg-1 x min-1).	Sulfhydryl Compounds	113-118	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	153-157
9452441-6	1998	Peroxynitrite had no effect in the absence of GSH but significantly stimulated the enzyme in the presence of the thiol (3.45 +/- 0.60 micromol of cGMP x mg-1 x min-1).	Sulfhydryl Compounds	113-118	CD59 molecule (CD59 blood group)	Homo sapiens	160-165
9452441-7	1998	The NO/O-2 donor SIN-1 caused only a slight accumulation of cGMP in the absence of GSH but was almost as effective as DEA/NO in the presence of the thiol.	Sulfhydryl Compounds	148-153	MAPK associated protein 1	Homo sapiens	17-22
9430691-8	1998	[14C]Iodoacetamide labeling of free thiols of cysteine residues in mutant connexin-43s showed that two pairs of intramolecular disulfide bonds are formed between Cys54 and Cys192 and between Cys187 and Cys198.	Sulfhydryl Compounds	36-42	gap junction protein alpha 1	Homo sapiens	74-85
9419340-3	1998	Herein we demonstrate that nitric oxide and other thiol oxidants can inhibit the autokinase activity of rat JAK2 in vitro, presumably through oxidation of crucial dithiols to disulfides within JAK2.	Sulfhydryl Compounds	50-55	Janus kinase 2	Rattus norvegicus	108-112
9419340-3	1998	Herein we demonstrate that nitric oxide and other thiol oxidants can inhibit the autokinase activity of rat JAK2 in vitro, presumably through oxidation of crucial dithiols to disulfides within JAK2.	Sulfhydryl Compounds	50-55	Janus kinase 2	Rattus norvegicus	193-197
9419340-6	1998	Furthermore, we observed that the autokinase activity of JAK3 responds in a similar fashion to thiol redox reagents in vitro and to nitric oxide donors in vivo.	Sulfhydryl Compounds	95-100	Janus kinase 3	Rattus norvegicus	57-61
9419340-7	1998	We suggest that the thiol redox regulation of JAKs may partially explain the generally immunosuppressive effects of nitric oxide and of other thiol oxidants.	Sulfhydryl Compounds	20-25	Janus kinase 2	Mus musculus	46-50
9419340-7	1998	We suggest that the thiol redox regulation of JAKs may partially explain the generally immunosuppressive effects of nitric oxide and of other thiol oxidants.	Sulfhydryl Compounds	142-147	Janus kinase 2	Mus musculus	46-50
9449305-7	1998	Mutants of a protease inhibitor, plasminogen activator inhibitor type-1 (PAI-1), containing one or two cysteine residues, were labeled with sulfhydryl specific derivatives of 4,4-difluoro-4-borata-3a-azonia-4a-aza-s-indacence (BODIPY).	Sulfhydryl Compounds	140-150	serpin family E member 1	Homo sapiens	73-78
9473671-7	1998	The thiol-oxidizing agent diamide also inhibited phosphoinositide hydrolysis stimulated by carbachol or NaF, and glutathione depletion potentiated the diamide concentration-dependent inhibition.	Sulfhydryl Compounds	4-9	C-X-C motif chemokine ligand 8	Homo sapiens	104-107
11063030-5	1998	The direct phosphoserine analysis on the purified bovine 20 kDa amelogenin indicated the presence of 0.8 moles of phosphoserine/mole protein naturally occurring, consistent with the quantitative analysis of 14C-radiolabeling of phosphoserines by conversion to dehydroalanine and in situ reaction with the thiol agent, 14C-mercaptoethanol, 0.64 moles 14C-incorporated/mole 20 kDa amelogenin.	Sulfhydryl Compounds	305-310	amelogenin, X isoform	Bos taurus	64-74
9386892-6	1998	On the other hand, in the CD38+ human Namalwa B lymphoid cells, NAD+ (and thiol compounds as well) induced a two-step process of self-aggregation followed by endocytosis of CD38, which resulted in a shift of cADPR metabolism from the cell surface to the cytosol.	Sulfhydryl Compounds	74-79	CD38 molecule	Homo sapiens	26-30
9386892-6	1998	On the other hand, in the CD38+ human Namalwa B lymphoid cells, NAD+ (and thiol compounds as well) induced a two-step process of self-aggregation followed by endocytosis of CD38, which resulted in a shift of cADPR metabolism from the cell surface to the cytosol.	Sulfhydryl Compounds	74-79	CD38 molecule	Homo sapiens	173-177
9488118-7	1998	Phenylalanine and leucine inhibited both MT-Cy- and CAM-dependent thiol production in D-PBS most effectively suggesting the involvement of the L membrane transport system in these effects.	Sulfhydryl Compounds	66-71	calmodulin 3	Homo sapiens	41-55
10651168-1	1998	We investigated the effects of the sulfhydryl-donor, N-acetylcysteine (NAC), on nitroglycerin (NTG)-induced relaxation of the vascular smooth muscle.	Sulfhydryl Compounds	35-45	synuclein alpha	Homo sapiens	71-74
10651168-8	1998	These results suggest that treatment with the sulfhydryl donor, NAC, inhibited the phosphorylation of desmin associated with the enhancement of NTG-induced relaxation, which might be related to the mechanisms of recovery from NTG tolerance by sulfhydryl groups.	Sulfhydryl Compounds	46-56	synuclein alpha	Homo sapiens	64-67
10651168-8	1998	These results suggest that treatment with the sulfhydryl donor, NAC, inhibited the phosphorylation of desmin associated with the enhancement of NTG-induced relaxation, which might be related to the mechanisms of recovery from NTG tolerance by sulfhydryl groups.	Sulfhydryl Compounds	46-56	desmin	Homo sapiens	102-108
9435172-5	1998	Treatment with diethyldithiocarbamic acid (a drug protecting against cDDP nephrotoxicity), immediately after cDDP exposure, 1) partially lifted the cDDP-induced inhibition of the Na+/glucose cotransporter, 2) reduced platinum binding to BBM vesicles, but 3) did not modify the cDDP-induced decrease in protein-bound thiols.	Sulfhydryl Compounds	316-322	sodium/nucleoside cotransporter	Oryctolagus cuniculus	179-207
21374461-3	1998	These complexities include variations in the degree of sialylation on the sugar chains and complex formation with low molecular weight thiols by disulfide bridges of the reactive single cysteine (6) Hereditary deficiency of alpha-1-anti-T predisposes to degenerative lung disease and liver disease (7,8).Nucleotide sequence studies of alpha-1-anti-T have shown single or two-base substitution or dinucleotide deletion with subsequent single amino acid substitutions or deletions.	Sulfhydryl Compounds	135-141	serpin family A member 1	Homo sapiens	224-238
21374461-3	1998	These complexities include variations in the degree of sialylation on the sugar chains and complex formation with low molecular weight thiols by disulfide bridges of the reactive single cysteine (6) Hereditary deficiency of alpha-1-anti-T predisposes to degenerative lung disease and liver disease (7,8).Nucleotide sequence studies of alpha-1-anti-T have shown single or two-base substitution or dinucleotide deletion with subsequent single amino acid substitutions or deletions.	Sulfhydryl Compounds	135-141	serpin family A member 1	Homo sapiens	335-349
9659913-2	1998	In a temperature-sensitive ero1-1 mutant, newly synthesized carboxypeptidase Y is retained in the ER and lacks disulfide bonds, as shown by thiol modification with AMS.	Sulfhydryl Compounds	140-145	ER oxidoreductin	Saccharomyces cerevisiae S288C	27-33
9683263-5	1998	C3, C4 and alpha2-macroglobulin contain an internal thiol ester bond linking cysteinyl and glutamic acid residues and methylamine inactivates all three proteins by reaction with the thiol-esterified glutamic acid.	Sulfhydryl Compounds	52-57	alpha-2-macroglobulin	Homo sapiens	11-31
9683263-8	1998	Thus the thiol ester proteins alpha2-macroglobulin and C3 operate very differently in the hemolytic systems of Limulus and mammals and are not functionally homologous.	Sulfhydryl Compounds	9-14	alpha-2-macroglobulin	Homo sapiens	30-50
9405384-0	1997	Identification of residues in the drug-binding site of human P-glycoprotein using a thiol-reactive substrate.	Sulfhydryl Compounds	84-89	ATP binding cassette subfamily B member 1	Homo sapiens	61-75
9706739-2	1998	It was demonstrated that submillimolar concentrations of the NO donor sodium nitroprusside (SNP) not only strongly inactivated GAPDH by S-nitrosylation of the enzyme thiols but also decreased the binding affinity of GAPDH for the RBC membrane.	Sulfhydryl Compounds	166-172	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	127-132
9706739-2	1998	It was demonstrated that submillimolar concentrations of the NO donor sodium nitroprusside (SNP) not only strongly inactivated GAPDH by S-nitrosylation of the enzyme thiols but also decreased the binding affinity of GAPDH for the RBC membrane.	Sulfhydryl Compounds	166-172	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	216-221
9706739-3	1998	In fact, the incubation with SNP for 60 min at 30 degrees C and at a concentration &gt; 50 microM induced the dissociation of the native GAPDH from the white unsealed membranes (standard ghosts) in a concentration-dependent manner with a partial recovery of the enzyme activity and thiols when SNP concentrations higher of 1 mM were used.	Sulfhydryl Compounds	282-288	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	137-142
9405384-1	1997	We identified a thiol-reactive compound, dibromobimane (dBBn), that was a potent stimulator (8.2-fold) of the ATPase activity of Cys-less P-glycoprotein.	Sulfhydryl Compounds	16-21	ATP binding cassette subfamily B member 1	Homo sapiens	138-152
9393673-2	1997	We have now extended these studies by measuring the effects of dinitrosyl-iron complexed thiols (DNIC-[RSH]2) on human GR, GST and glutathione peroxidase.	Sulfhydryl Compounds	89-95	glutathione-disulfide reductase	Homo sapiens	119-121
18642336-3	1997	PDI inactivation during coupling reaction was overcome by oxidizing active site thiols with dimethylsulfoxide and led to a 64% active enzyme.	Sulfhydryl Compounds	80-86	protein disulfide isomerase family A member 2	Homo sapiens	0-3
9396728-2	1997	The covalent complex has been prepared by introducing a disulphide bond between Cys-1 of P21 and Lys-13 of Mp, previously modified with a thiol-containing reagent.	Sulfhydryl Compounds	138-143	cystin 1	Homo sapiens	80-85
9398324-2	1997	As a result, the cytosine moiety of dCMP is displaced from the active site and the catalytic thiol is moved from the C6 of the substrate about 0.5 A further than in the wild-type TS-dUMP complex.	Sulfhydryl Compounds	93-98	cmp	Drosophila melanogaster	36-40
9396728-2	1997	The covalent complex has been prepared by introducing a disulphide bond between Cys-1 of P21 and Lys-13 of Mp, previously modified with a thiol-containing reagent.	Sulfhydryl Compounds	138-143	H3 histone pseudogene 16	Homo sapiens	89-92
9461346-1	1997	By exploiting the thiol function of L-cysteine as a chelating group of the active-site zinc atom of matrix metalloproteinases (MMPs), N- and C-terminal derivatization of this amino acid with aliphatic and aromatic groups allowed us to explore the selectivity of the S and/or S" binding subsites of human neutrophil collagenase (MMP8) and stromelysin (MMP3).	Sulfhydryl Compounds	18-23	matrix metallopeptidase 3	Homo sapiens	127-131
9409558-3	1997	Thioredoxin (TRX) is a potent protein disulfide reductase found in most organisms that participates in many thiol-dependent cellular reductive processes and plays an important role in antioxidant defense, signal transduction, and regulation of cell growth and proliferation.	Sulfhydryl Compounds	108-113	thioredoxin	Homo sapiens	0-11
9409558-3	1997	Thioredoxin (TRX) is a potent protein disulfide reductase found in most organisms that participates in many thiol-dependent cellular reductive processes and plays an important role in antioxidant defense, signal transduction, and regulation of cell growth and proliferation.	Sulfhydryl Compounds	108-113	thioredoxin	Homo sapiens	13-16
9409558-8	1997	Thiol oxidation by diamide or alkylation by chlorodinitrobenzene inhibited MnSOD induction, further indicating a requirement for reduced TRX.	Sulfhydryl Compounds	0-5	superoxide dismutase 2	Homo sapiens	75-80
9409558-8	1997	Thiol oxidation by diamide or alkylation by chlorodinitrobenzene inhibited MnSOD induction, further indicating a requirement for reduced TRX.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	137-140
9450496-0	1997	Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine.	Sulfhydryl Compounds	43-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-19
9437520-10	1997	In conclusion, our study shows that caspases are quite sensitive to thiol oxidation and that DSF is a very potent oxidant of caspase protein thiol(s), being 700-fold more potent than glutathione disulfide.	Sulfhydryl Compounds	68-73	caspase 1	Homo sapiens	36-44
9437520-10	1997	In conclusion, our study shows that caspases are quite sensitive to thiol oxidation and that DSF is a very potent oxidant of caspase protein thiol(s), being 700-fold more potent than glutathione disulfide.	Sulfhydryl Compounds	68-73	caspase 1	Homo sapiens	36-43
9450496-10	1997	A concentration of 4 mM of the disulfide form reduced gene expression to 45% of the control level, while the thiol form was less effective, with 4 mM and 40 microM concentrations reducing c-myc gene expression to 65% and 46% of control levels, respectively.	Sulfhydryl Compounds	109-114	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	188-193
9388242-9	1997	Here, we describe a new human thioredoxin peroxidase, antioxidant enzyme AOE372, identified by virtue of its protein-protein interaction with the product of a proliferation association gene, pag, which is also a thiol-specific antioxidant.	Sulfhydryl Compounds	212-217	thioredoxin	Homo sapiens	30-41
9388242-9	1997	Here, we describe a new human thioredoxin peroxidase, antioxidant enzyme AOE372, identified by virtue of its protein-protein interaction with the product of a proliferation association gene, pag, which is also a thiol-specific antioxidant.	Sulfhydryl Compounds	212-217	peroxiredoxin 4	Homo sapiens	73-79
9543006-7	1997	By careful examination of the effects of different sulfhydryl reagents, metal ion cofactors and substrates on lambda-PPase, it was found that the role of sulfhydryl reagents was the chelation of small amounts of inhibitory metal ions, which were present in plastic laboratory ware, such as disposable cuvets and tubes, with prevention of the enzyme from inactivation.	Sulfhydryl Compounds	51-61	inorganic pyrophosphatase 1	Homo sapiens	117-122
9436825-6	1997	Tested daily were (a) the dilation of the epicardial arteries, (b) thrombin-induced (0.5 U/ml) increases of the intracellular Ca2+ concentration and aggregability of platelets, (c) concentrations of reduced low-molecular-weight thiols (LMTs) in plasma and platelets, and (d) formation of reactive oxygen species (ROSs).	Sulfhydryl Compounds	228-234	coagulation factor II, thrombin	Homo sapiens	67-75
9450663-9	1997	The present results demonstrate that regucalcin has a stimulatory effect on ATP-dependent Ca2+ uptake in the microsomes of rat renal cortex due to acting on the thiol groups of Ca2+-ATPase.	Sulfhydryl Compounds	161-166	regucalcin	Rattus norvegicus	37-47
9440542-0	1997	A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-kappaB.	Sulfhydryl Compounds	2-7	nuclear factor kappa B subunit 1	Homo sapiens	80-101
9440542-3	1997	In both cell lines, n-acetyl-L-cysteine (NAC), a potent thiol antioxidant, inhibited the triggering of the nuclear expression of NF-kappaB by IL-4 and by anti-CD40 monoclonal antibody.	Sulfhydryl Compounds	56-61	nuclear factor kappa B subunit 1	Homo sapiens	129-138
9464857-2	1997	In addition, thioredoxin participates in the regulation of different metabolic processes via thiol redox control.	Sulfhydryl Compounds	93-98	thioredoxin	Homo sapiens	13-24
9368033-6	1997	Limited proteolysis and thiol reactivity suggest that that the C terminus of full-length CR, but not of CR-22k, is in close proximity of site I leading to mutual shielding.	Sulfhydryl Compounds	24-29	calbindin 2	Homo sapiens	89-91
9368022-1	1997	The thioredoxin system, composed of the pyridine nucleotide-disulfide oxidoreductase thioredoxin reductase, the small peptide thioredoxin, and NADPH as a reducing cofactor, is one of the major thiol-reducing systems of the cell.	Sulfhydryl Compounds	193-198	thioredoxin	Homo sapiens	4-15
9368022-9	1997	These results clearly identify Cys88 and Cys93 as the active site thiols of large thioredoxin reductase.	Sulfhydryl Compounds	66-72	thioredoxin	Homo sapiens	82-93
9385634-9	1997	The present study, therefore, raises the possibility that the biological roles of Lp(a) may be mediated by its state of oxidation, especially in light of our previous study showing that the reductive properties of sulfhydryl-containing compounds increase the LBS affinity of Lp(a) for fibrin.	Sulfhydryl Compounds	214-224	lipoprotein(a)	Homo sapiens	82-87
9366707-1	1997	BACKGROUND: We have previously shown that the thiol-oxidizing agent diethyl maleate prevents lipopolysaccharide (LPS)-induced up-regulation of endothelial cell intercellular adhesion molecule-1 (ICAM-1) in vitro.	Sulfhydryl Compounds	46-51	intercellular adhesion molecule 1	Mus musculus	160-193
9366707-1	1997	BACKGROUND: We have previously shown that the thiol-oxidizing agent diethyl maleate prevents lipopolysaccharide (LPS)-induced up-regulation of endothelial cell intercellular adhesion molecule-1 (ICAM-1) in vitro.	Sulfhydryl Compounds	46-51	intercellular adhesion molecule 1	Mus musculus	195-201
9369170-1	1997	Thioredoxin is a major cellular dithiol reductant with a large number of functions in electron transport and thiol redox control of enzymes and transcription factors.	Sulfhydryl Compounds	34-39	thioredoxin 1	Rattus norvegicus	0-11
9394832-0	1997	Thiol modulation inhibits the interleukin (IL)-1-mediated activation of an IL-1 receptor-associated protein kinase and NF-kappa B.	Sulfhydryl Compounds	0-5	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-129
9394832-9	1997	Thiol modifying agents like diamide, menadione, pyrrolidine dithiocarbamate (PDTC), diethyl dithiocarbamate or phenylarsine oxide inhibited the IL-1-induced activation of the IL-1RI-associated protein kinase.	Sulfhydryl Compounds	0-5	interleukin 1 receptor, type I	Mus musculus	175-181
9394832-13	1997	From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.	Sulfhydryl Compounds	46-52	interleukin 1 receptor, type I	Mus musculus	60-66
9394832-13	1997	From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.	Sulfhydryl Compounds	46-52	interleukin 1 receptor, type I	Mus musculus	115-121
9394832-13	1997	From these observations we conclude that free thiols in the IL-1RI complex are essential for the activation of the IL-1RI-associated protein kinase and that this process is mandatory for IL-1 signaling leading to NF-kappa B activation.	Sulfhydryl Compounds	46-52	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	213-223
9433922-3	1997	The thiol reagent, thimerosal, which induces oscillations of intracellular Ca2+ ([Ca2+]i) similar to those seen during fertilization, was used to mobilize Ca2+ in in-vivo matured, immature and in-vitro matured human oocytes.	Sulfhydryl Compounds	4-9	carbonic anhydrase 2	Homo sapiens	75-78
9433922-3	1997	The thiol reagent, thimerosal, which induces oscillations of intracellular Ca2+ ([Ca2+]i) similar to those seen during fertilization, was used to mobilize Ca2+ in in-vivo matured, immature and in-vitro matured human oocytes.	Sulfhydryl Compounds	4-9	carbonic anhydrase 2	Homo sapiens	82-85
9433922-3	1997	The thiol reagent, thimerosal, which induces oscillations of intracellular Ca2+ ([Ca2+]i) similar to those seen during fertilization, was used to mobilize Ca2+ in in-vivo matured, immature and in-vitro matured human oocytes.	Sulfhydryl Compounds	4-9	carbonic anhydrase 2	Homo sapiens	82-85
9371773-10	1997	Inhibition of NF-kappaB activity by selenite is presumed to be the result of adduct formation with the essential thiols of this transcription factor.	Sulfhydryl Compounds	113-119	nuclear factor kappa B subunit 1	Homo sapiens	14-23
9371870-1	1997	Substitution of the oxidation-sensitive thiol function of mercaptoacetyltriglycine (MAG3) by a hydroxyl group yields a tetraligand (hydroxyacetyltriglycine or HAG3) which is almost insensitive to oxidation and has the advantage over MAG3 that it can be stored safely without protection of the alcohol function.	Sulfhydryl Compounds	40-45	anterior gradient 3, protein disulphide isomerase family member	Homo sapiens	159-163
9385634-9	1997	The present study, therefore, raises the possibility that the biological roles of Lp(a) may be mediated by its state of oxidation, especially in light of our previous study showing that the reductive properties of sulfhydryl-containing compounds increase the LBS affinity of Lp(a) for fibrin.	Sulfhydryl Compounds	214-224	lipoprotein(a)	Homo sapiens	275-280
9346948-5	1997	The SP-Ahyp and SP-ADeltaG8-P80 were at least nonameric in solution based on gel exclusion chromatography, and demonstrated extensive sulfhydryl-dependent oligomerization under nonreducing conditions.	Sulfhydryl Compounds	134-144	surfactant protein A1	Rattus norvegicus	4-11
9342345-3	1997	Using in vitro translation in the absence or presence of transport competent microsomes we found that newly synthesized sulfatase polypeptides carry a cysteine residue and that the oxidation of its thiol group to an aldehyde is catalyzed in the endoplasmic reticulum.	Sulfhydryl Compounds	198-203	arylsulfatase family member H	Homo sapiens	120-129
9355742-8	1997	Treatment of this protein with thiol agents suggested that it is an oligomer containing pNR-2/pS2 linked to another protein by a disulphide bond.	Sulfhydryl Compounds	31-36	trefoil factor 1	Homo sapiens	88-93
9355763-0	1997	Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid.	Sulfhydryl Compounds	48-54	myeloperoxidase	Homo sapiens	58-73
9373190-6	1997	Thus free sulfhydryls were important in DNA binding activity of CREP, NFkappaB and HSF, and the lack of induction of NFkappaB by H2O2 in intact cells was likely caused by oxidation on a thiol, and not by a deficiency in the activation pathway.	Sulfhydryl Compounds	10-21	protein phosphatase 1 regulatory subunit 15B	Homo sapiens	64-68
9373190-6	1997	Thus free sulfhydryls were important in DNA binding activity of CREP, NFkappaB and HSF, and the lack of induction of NFkappaB by H2O2 in intact cells was likely caused by oxidation on a thiol, and not by a deficiency in the activation pathway.	Sulfhydryl Compounds	10-21	interleukin 6	Homo sapiens	83-86
9359401-7	1997	Ubiquitin conjugation assays show that, in addition to accepting a thiol-bound ubiquitin at its active site, UBC-1 is stably mono-ubiquitinated.	Sulfhydryl Compounds	67-72	Ubiquitin	Caenorhabditis elegans	0-9
9359401-7	1997	Ubiquitin conjugation assays show that, in addition to accepting a thiol-bound ubiquitin at its active site, UBC-1 is stably mono-ubiquitinated.	Sulfhydryl Compounds	67-72	Ubiquitin	Caenorhabditis elegans	79-88
9359401-7	1997	Ubiquitin conjugation assays show that, in addition to accepting a thiol-bound ubiquitin at its active site, UBC-1 is stably mono-ubiquitinated.	Sulfhydryl Compounds	67-72	Ubiquitin-conjugating enzyme E2 1	Caenorhabditis elegans	109-114
9312113-5	1997	Alkylation of hyperreactive sulfhydryls on RYR1 with N-ethylmaleimide (NEM) inhibits channel function and blocks the intersubunit cross-linking.	Sulfhydryl Compounds	28-39	ryanodine receptor 1	Homo sapiens	43-47
9355742-8	1997	Treatment of this protein with thiol agents suggested that it is an oligomer containing pNR-2/pS2 linked to another protein by a disulphide bond.	Sulfhydryl Compounds	31-36	trefoil factor 1	Homo sapiens	94-97
23282805-8	1997	Glyceraldehyde-3-phosphate dehydrogenase activity, previously shown to be inactivated by thiol oxidation in inflamed but not in noninflamed IBD epithelium, and total reduced thiol content were also significantly decreased by 33.8 and 26.3%, respectively (p &lt; 0.001).	Sulfhydryl Compounds	89-94	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	0-40
9535167-5	1997	From these studies, a picture of TS emerges where ligand-induced conformational changes play key roles in catalysis by straining the thiol adduct that occurs during the reaction; by protecting the highly reactive reaction intermediates; and by providing a means to stabilize a high-energy conformer of the cofactor after initial binding of a low-energy conformer.	Sulfhydryl Compounds	133-138	thymidylate synthetase	Homo sapiens	33-35
9338443-1	1997	Nitric oxide (NO) may exert direct effects on actin-myosin cross-bridge cycling by modulating critical thiols on the myosin head.	Sulfhydryl Compounds	103-109	myosin heavy chain 14	Homo sapiens	52-58
9338443-1	1997	Nitric oxide (NO) may exert direct effects on actin-myosin cross-bridge cycling by modulating critical thiols on the myosin head.	Sulfhydryl Compounds	103-109	myosin heavy chain 14	Homo sapiens	117-123
9338443-7	1997	The effects of SNP, but not NEM, on force and actomyosin ATPase activity were reversed by treatment with 10 mM DL-dithiothreitol, a thiol-reducing agent.	Sulfhydryl Compounds	132-137	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	57-63
9326301-1	1997	In the presence of thiols, tyrosine hydroxylase (TH) oxidizes L-dihydroxyphenylalanine (L-DOPA) with a specific activity of up to 140 nmol min(-1) mg(-1) at 37 degrees C and pH 7.0, which is approximately 12-50% of its TH activity under similar experimental conditions.	Sulfhydryl Compounds	19-25	tyrosine hydroxylase	Homo sapiens	27-47
9326301-1	1997	In the presence of thiols, tyrosine hydroxylase (TH) oxidizes L-dihydroxyphenylalanine (L-DOPA) with a specific activity of up to 140 nmol min(-1) mg(-1) at 37 degrees C and pH 7.0, which is approximately 12-50% of its TH activity under similar experimental conditions.	Sulfhydryl Compounds	19-25	tyrosine hydroxylase	Homo sapiens	49-51
9326301-1	1997	In the presence of thiols, tyrosine hydroxylase (TH) oxidizes L-dihydroxyphenylalanine (L-DOPA) with a specific activity of up to 140 nmol min(-1) mg(-1) at 37 degrees C and pH 7.0, which is approximately 12-50% of its TH activity under similar experimental conditions.	Sulfhydryl Compounds	19-25	tyrosine hydroxylase	Homo sapiens	219-221
9326301-4	1997	Theoretically, the oxidation of L-DOPA by TH may contribute to the formation of neuromelanin (pheomelanin) in catecholaminergic neurons and in the metabolism of DOPA to reactive intermediates that can react with free thiol groups in cellular proteins.	Sulfhydryl Compounds	217-222	tyrosine hydroxylase	Homo sapiens	42-44
9323023-0	1997	Thiols and disulphides can aggravate peroxynitrite-dependent inactivation of alpha1-antiproteinase.	Sulfhydryl Compounds	0-6	serpin family A member 1	Homo sapiens	77-98
9287150-10	1997	That the thiol-binding subsite exists also in AspRS and SerRS, which do not need editing function, suggests that these class II enzymes possess vestigial editing functions.	Sulfhydryl Compounds	9-14	aspartyl-tRNA synthetase 1	Homo sapiens	46-51
9287150-10	1997	That the thiol-binding subsite exists also in AspRS and SerRS, which do not need editing function, suggests that these class II enzymes possess vestigial editing functions.	Sulfhydryl Compounds	9-14	seryl-tRNA synthetase 1	Homo sapiens	56-61
9287169-2	1997	Single- and double-cysteine substitution mutagenesis was utilized to place sulfhydryl residues throughout the tertiary structure of the bidomain enzyme yeast phosphoglycerate kinase (PGK).	Sulfhydryl Compounds	75-85	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	158-181
9287169-2	1997	Single- and double-cysteine substitution mutagenesis was utilized to place sulfhydryl residues throughout the tertiary structure of the bidomain enzyme yeast phosphoglycerate kinase (PGK).	Sulfhydryl Compounds	75-85	phosphoglycerate kinase	Saccharomyces cerevisiae S288C	183-186
9333022-0	1997	Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols.	Sulfhydryl Compounds	102-108	B cell leukemia/lymphoma 2	Mus musculus	45-50
9333022-4	1997	These results are consistent with the general idea that Bcl-2 expression blocks apoptosis through an antioxidant pathway that involves cellular thiols.	Sulfhydryl Compounds	144-150	B cell leukemia/lymphoma 2	Mus musculus	56-61
9333022-5	1997	That Bcl-2-expressing tumor cells can be sensitized by exogeneous agents that modify cellular thiols offers strategies for overcoming such resistance.	Sulfhydryl Compounds	94-100	B cell leukemia/lymphoma 2	Mus musculus	5-10
9323023-5	1997	We suggest that sulphur-containing radicals are produced by reaction of certain thiols/disulphides with ONOO- or ONOO- -derived products and could mediate biological damage, including inactivation of alpha1AP.	Sulfhydryl Compounds	80-86	serpin family A member 1	Homo sapiens	200-208
9323023-4	1997	At low thiol:ONOO- concentration ratios, several thiols (captopril, penicillamine, cysteine, cystine and penicillamine disulphide) aggravated inactivation of alpha1AP by ONOO- , whereas GSH, GSSG, homocysteine, ergothioneine, N-acetylcysteine, lipoate and dihydrolipoate did not.	Sulfhydryl Compounds	7-12	serpin family A member 1	Homo sapiens	158-166
9323023-4	1997	At low thiol:ONOO- concentration ratios, several thiols (captopril, penicillamine, cysteine, cystine and penicillamine disulphide) aggravated inactivation of alpha1AP by ONOO- , whereas GSH, GSSG, homocysteine, ergothioneine, N-acetylcysteine, lipoate and dihydrolipoate did not.	Sulfhydryl Compounds	49-55	serpin family A member 1	Homo sapiens	158-166
9315326-6	1997	On the other hand, structural and kinetic data indicate that also the specificity of PHGPx for the donor substrate is not restricted to GSH and the recent observation the PHGPx binds to specific mitochondrial proteins, from which it is released by ionic strength and thiols, suggests a possible fole of this selenoenzyme in catalyzing the specific oxidation of protein thiols, thus modulating the activity of cellular regulatory elements.	Sulfhydryl Compounds	267-273	glutathione peroxidase 4	Homo sapiens	85-90
9283092-0	1997	Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C. A number of protein reactive compounds, including the thiol reagents diamide and arsenite, are known inducers of heat shock protein (HSP) synthesis and thermotolerance.	Sulfhydryl Compounds	64-69	10 kDa heat shock protein, mitochondrial	Cricetulus griseus	262-280
9283092-0	1997	Destabilization of the Ca2+-ATPase of sarcoplasmic reticulum by thiol-specific, heat shock inducers results in thermal denaturation at 37 degrees C. A number of protein reactive compounds, including the thiol reagents diamide and arsenite, are known inducers of heat shock protein (HSP) synthesis and thermotolerance.	Sulfhydryl Compounds	64-69	10 kDa heat shock protein, mitochondrial	Cricetulus griseus	282-285
9278421-10	1997	The effect of proteasome inhibitors on the normoxic induction of HIF-1 binding activity was mimicked by the thiol reducing agent N-(2-mercaptopropionyl)-glycine and by the oxygen radical scavenger 2-acetamidoacrylic acid.	Sulfhydryl Compounds	108-113	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-70
9315326-6	1997	On the other hand, structural and kinetic data indicate that also the specificity of PHGPx for the donor substrate is not restricted to GSH and the recent observation the PHGPx binds to specific mitochondrial proteins, from which it is released by ionic strength and thiols, suggests a possible fole of this selenoenzyme in catalyzing the specific oxidation of protein thiols, thus modulating the activity of cellular regulatory elements.	Sulfhydryl Compounds	267-273	glutathione peroxidase 4	Homo sapiens	171-176
9315326-6	1997	On the other hand, structural and kinetic data indicate that also the specificity of PHGPx for the donor substrate is not restricted to GSH and the recent observation the PHGPx binds to specific mitochondrial proteins, from which it is released by ionic strength and thiols, suggests a possible fole of this selenoenzyme in catalyzing the specific oxidation of protein thiols, thus modulating the activity of cellular regulatory elements.	Sulfhydryl Compounds	369-375	glutathione peroxidase 4	Homo sapiens	85-90
9315326-6	1997	On the other hand, structural and kinetic data indicate that also the specificity of PHGPx for the donor substrate is not restricted to GSH and the recent observation the PHGPx binds to specific mitochondrial proteins, from which it is released by ionic strength and thiols, suggests a possible fole of this selenoenzyme in catalyzing the specific oxidation of protein thiols, thus modulating the activity of cellular regulatory elements.	Sulfhydryl Compounds	369-375	glutathione peroxidase 4	Homo sapiens	171-176
9315326-7	1997	On this light, the selenium mojety of PHGPx, reacting much faster that thiols with a peroxide, and then oxidizing specific protein thiols, would channel the oxidation toward protein targets, thus providing, by protein-protein interaction, the specificity of the redox transition.	Sulfhydryl Compounds	71-77	glutathione peroxidase 4	Homo sapiens	38-43
9315326-7	1997	On this light, the selenium mojety of PHGPx, reacting much faster that thiols with a peroxide, and then oxidizing specific protein thiols, would channel the oxidation toward protein targets, thus providing, by protein-protein interaction, the specificity of the redox transition.	Sulfhydryl Compounds	131-137	glutathione peroxidase 4	Homo sapiens	38-43
9250120-9	1997	Diminished cell growth and altered polyamine concentrations suggest that S-allylmercaptocysteine may impede the polyamine synthesizing enzyme, ornithine decarboxylase, either by enhancing the formation of reduced glutathione, a known inhibitor of ornithine decarboxylase, or by reacting directly with ornithine decarboxylase at its nucleophilic thiol moiety.	Sulfhydryl Compounds	345-350	ornithine decarboxylase 1	Homo sapiens	143-166
9352231-2	1997	The thiol compounds were liberated from plasma proteins by reduction with tri-n-butylphosphine and derivatized with a thiol-specific fluorogenic marker, 7-fluoro-benzo-2-oxa-1,3-diazole-4-sulphonate.	Sulfhydryl Compounds	4-9	OXA1L mitochondrial inner membrane protein	Homo sapiens	170-175
9352231-2	1997	The thiol compounds were liberated from plasma proteins by reduction with tri-n-butylphosphine and derivatized with a thiol-specific fluorogenic marker, 7-fluoro-benzo-2-oxa-1,3-diazole-4-sulphonate.	Sulfhydryl Compounds	118-123	OXA1L mitochondrial inner membrane protein	Homo sapiens	170-175
9310371-3	1997	The ligand-free receptor was purified by dissociating the ligand x receptor complex with 2 M NaSCN, whereas the ligand-bound ET(B)R was purified by the use of thiol-sensitive biotinylated endothelin-1.	Sulfhydryl Compounds	159-164	endothelin receptor type B	Homo sapiens	125-131
9310371-3	1997	The ligand-free receptor was purified by dissociating the ligand x receptor complex with 2 M NaSCN, whereas the ligand-bound ET(B)R was purified by the use of thiol-sensitive biotinylated endothelin-1.	Sulfhydryl Compounds	159-164	endothelin 1	Homo sapiens	188-200
9378502-10	1997	Finally, we demonstrated that CyPB-receptor-positive cells, isolated on CyPB sulphydryl-coupled affinity matrices, are more sensitive to CyPB-complexed CsA than mixed peripheral blood lymphocytes, suggesting that CyPB potentiates CsA activity through the binding of the complex.	Sulfhydryl Compounds	77-87	peptidylprolyl isomerase B	Homo sapiens	30-34
9228051-12	1997	than control media to which an equivalent amount of synthetic PAF was added (0.59 +/- 0.02 micromol of thiol/micromol of albumin) (measured with Ellman"s reagent).	Sulfhydryl Compounds	103-108	PCNA clamp associated factor	Homo sapiens	62-65
9297571-5	1997	Recent advances in the function and chemistry of proteins involved in gene expression have indicated that thiol groups in the "pro-inflammatory" transcription factors AP-1 and NF-kappa B are targets for at least some of the therapeutic effects of disease modifying anti-rheumatic drugs.	Sulfhydryl Compounds	106-111	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	167-171
9297571-5	1997	Recent advances in the function and chemistry of proteins involved in gene expression have indicated that thiol groups in the "pro-inflammatory" transcription factors AP-1 and NF-kappa B are targets for at least some of the therapeutic effects of disease modifying anti-rheumatic drugs.	Sulfhydryl Compounds	106-111	nuclear factor kappa B subunit 1	Homo sapiens	176-186
9286074-9	1997	By contrast the use of the thiol coupling chemistry with the Fab" fragment gave a five fold increase in observed KA, resulting in a similar affinity to that observed with the intact IgG molecule.	Sulfhydryl Compounds	27-32	FA complementation group B	Homo sapiens	61-64
9177237-1	1997	TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including medications such as mercaptopurine and thioguanine.	Sulfhydryl Compounds	89-109	thiopurine S-methyltransferase	Homo sapiens	0-4
9240427-0	1997	Cigarette smoke extract inhibits plasma paraoxonase activity by modification of the enzyme"s free thiols.	Sulfhydryl Compounds	98-104	paraoxonase 1	Homo sapiens	40-51
9240427-7	1997	Furthermore, we tested to see whether sulfhydryl compounds prevented the inhibition of PON activity caused by CSE.	Sulfhydryl Compounds	38-58	paraoxonase 1	Homo sapiens	87-90
9240427-8	1997	Sulfhydryl compounds prevented the inhibition of PON activity caused by CSE.	Sulfhydryl Compounds	0-20	paraoxonase 1	Homo sapiens	49-52
9202002-0	1997	Kinetics and thioredoxin specificity of thiol modulation of the chloroplast H+-ATPase.	Sulfhydryl Compounds	40-45	ATPase	Escherichia coli	79-85
9202002-1	1997	The kinetics of thiol modulation of the chloroplast H+-ATPase (CF0CF1) in membrana were analyzed by employing thioredoxins that were kept reduced by 0.1 mM dithiothreitol.	Sulfhydryl Compounds	16-21	ATPase	Escherichia coli	55-61
9331970-4	1997	Activities of ADO and beta-carotene-15,15"-dioxygenase (CDO) were detected in the presence of thiols and were inactivated by 1,10-phenanthroline.	Sulfhydryl Compounds	94-100	beta-carotene oxygenase 1	Rattus norvegicus	22-54
9331970-4	1997	Activities of ADO and beta-carotene-15,15"-dioxygenase (CDO) were detected in the presence of thiols and were inactivated by 1,10-phenanthroline.	Sulfhydryl Compounds	94-100	beta-carotene oxygenase 1	Rattus norvegicus	56-59
9216735-0	1997	Membrane-bound proteindisulfide isomerase (PDI) is involved in regulation of surface expression of thiols and drug sensitivity of B-CLL cells.	Sulfhydryl Compounds	99-105	prolyl 4-hydroxylase subunit beta	Homo sapiens	15-41
9216735-0	1997	Membrane-bound proteindisulfide isomerase (PDI) is involved in regulation of surface expression of thiols and drug sensitivity of B-CLL cells.	Sulfhydryl Compounds	99-105	prolyl 4-hydroxylase subunit beta	Homo sapiens	43-46
9216735-12	1997	These data suggest for the first time a regulatory effect of PDI on the surface protein thiol status of B cells.	Sulfhydryl Compounds	88-93	prolyl 4-hydroxylase subunit beta	Homo sapiens	61-64
9182559-1	1997	Endopeptidase 24.16 or mitochondrial oligopeptidase, abbreviated here as EP 24.16 (MOP), is a thiol- and metal-dependent oligopeptidase that is found in multiple intracellular compartments in mammalian cells.	Sulfhydryl Compounds	94-99	neurolysin	Homo sapiens	0-19
9182559-1	1997	Endopeptidase 24.16 or mitochondrial oligopeptidase, abbreviated here as EP 24.16 (MOP), is a thiol- and metal-dependent oligopeptidase that is found in multiple intracellular compartments in mammalian cells.	Sulfhydryl Compounds	94-99	neurolysin	Homo sapiens	83-86
9218484-0	1997	Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells.	Sulfhydryl Compounds	0-5	heme oxygenase 1	Bos taurus	57-73
9211880-0	1997	Thiol activation of endopeptidase EC 3.4.24.15.	Sulfhydryl Compounds	0-5	thimet oligopeptidase 1	Homo sapiens	20-46
9211880-3	1997	Unlike other thermolysin-like peptidases EP24.15 displays a unique thiol activation, a mechanism that is not clearly understood.	Sulfhydryl Compounds	67-72	thimet oligopeptidase 1	Homo sapiens	41-48
9260673-6	1997	However, there are considerable reservations over its use for the spectrophotometric determination of thiols because of the possibility of side reactions which generate another Ellmans based species (ESO2-).	Sulfhydryl Compounds	102-108	cancer/testis antigen 2	Homo sapiens	200-204
9260673-7	1997	The assay described determines the thiol as a derivatised mixed disulphide (ESSR) and since speciation between the anion ES- and the oxidation product ESO2- occurs it enables the process of oxidation to be monitored simultaneously.	Sulfhydryl Compounds	35-40	cancer/testis antigen 2	Homo sapiens	151-155
9169404-10	1997	We have also found that two cellular thiol-reactive proteins, thioredoxin and Ref-1, work effectively and synergistically for activation of the Runt domain.	Sulfhydryl Compounds	37-42	thioredoxin	Homo sapiens	62-73
9169404-10	1997	We have also found that two cellular thiol-reactive proteins, thioredoxin and Ref-1, work effectively and synergistically for activation of the Runt domain.	Sulfhydryl Compounds	37-42	tissue factor pathway inhibitor 2	Homo sapiens	78-83
9187486-14	1997	Furthermore, the presence of Bcl-2 protected cells from thiol imbalance and prevented thiol loss following exposure to dopamine.	Sulfhydryl Compounds	56-61	BCL2, apoptosis regulator	Rattus norvegicus	29-34
9166850-1	1997	Using thiol deprivation, we have previously shown that the response of natural killer (NK) cells to interleukin-2 (IL-2) is subject to redox regulation downstream of IL-2 binding and internalization.	Sulfhydryl Compounds	6-11	interleukin 2	Homo sapiens	100-113
9166850-1	1997	Using thiol deprivation, we have previously shown that the response of natural killer (NK) cells to interleukin-2 (IL-2) is subject to redox regulation downstream of IL-2 binding and internalization.	Sulfhydryl Compounds	6-11	interleukin 2	Homo sapiens	115-119
9166850-1	1997	Using thiol deprivation, we have previously shown that the response of natural killer (NK) cells to interleukin-2 (IL-2) is subject to redox regulation downstream of IL-2 binding and internalization.	Sulfhydryl Compounds	6-11	interleukin 2	Homo sapiens	166-170
9166850-7	1997	The in vitro kinase activities of CDK6 and CDK2 were prematurely increased by thiol deprivation.	Sulfhydryl Compounds	78-83	cyclin dependent kinase 6	Homo sapiens	34-38
9166850-7	1997	The in vitro kinase activities of CDK6 and CDK2 were prematurely increased by thiol deprivation.	Sulfhydryl Compounds	78-83	cyclin dependent kinase 2	Homo sapiens	43-47
9208169-12	1997	Significantly, dithiothreitol reduction of the DC disulfide abolished its inhibition of in vitro proenzyme processing, thereby demonstrating thiol-disulfide exchange between the DC disulfide and a free thiol group on an activator(s) of caspase-3.	Sulfhydryl Compounds	141-146	caspase 3	Homo sapiens	236-245
9208169-12	1997	Significantly, dithiothreitol reduction of the DC disulfide abolished its inhibition of in vitro proenzyme processing, thereby demonstrating thiol-disulfide exchange between the DC disulfide and a free thiol group on an activator(s) of caspase-3.	Sulfhydryl Compounds	202-207	caspase 3	Homo sapiens	236-245
9187486-14	1997	Furthermore, the presence of Bcl-2 protected cells from thiol imbalance and prevented thiol loss following exposure to dopamine.	Sulfhydryl Compounds	86-91	BCL2, apoptosis regulator	Rattus norvegicus	29-34
9208169-0	1997	Mechanism of dithiocarbamate inhibition of apoptosis: thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme.	Sulfhydryl Compounds	54-59	caspase 3	Homo sapiens	136-145
9169017-0	1997	The mechanism of apolipoprotein B-100 thiol depletion during oxidative modification of low-density lipoprotein.	Sulfhydryl Compounds	38-43	apolipoprotein B	Homo sapiens	17-37
9215707-3	1997	EAAC1 (neuronal), GLT1 and GLAST (glial), possess a redox-sensing property, undergoing opposite functional changes in response to oxidation or reduction of reactive sulphydryls present in their structure.	Sulfhydryl Compounds	165-176	solute carrier family 1 member 1	Rattus norvegicus	0-5
9215707-3	1997	EAAC1 (neuronal), GLT1 and GLAST (glial), possess a redox-sensing property, undergoing opposite functional changes in response to oxidation or reduction of reactive sulphydryls present in their structure.	Sulfhydryl Compounds	165-176	solute carrier family 1 member 2	Rattus norvegicus	18-22
9215707-3	1997	EAAC1 (neuronal), GLT1 and GLAST (glial), possess a redox-sensing property, undergoing opposite functional changes in response to oxidation or reduction of reactive sulphydryls present in their structure.	Sulfhydryl Compounds	165-176	solute carrier family 1 member 3	Rattus norvegicus	27-32
9182756-0	1997	Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form.	Sulfhydryl Compounds	36-41	perforin 1	Homo sapiens	52-61
9182756-2	1997	Here, we present the first crystal structure of a thiol-activated cytolysin, perfringolysin O, a member of a large family of toxins that kill eukaryotic cells by punching holes in their membranes.	Sulfhydryl Compounds	50-55	perforin 1	Homo sapiens	66-75
9152014-11	1997	In summary, this study has shown that: (1) Cd increases MT, GST, and HO gene expression in a time- and dose-dependent fashion: (2) MT gene expression appears to be most sensitive to Cd whereas the HO gene is most inducible at higher Cd concentrations; (3) Cd-induced expression is enhanced by GSH depletion and suppressed by thiol supplementation.	Sulfhydryl Compounds	325-330	metallothionein 1	Rattus norvegicus	131-133
9169017-3	1997	In this report, we have evaluated the antioxidant potential of apolipoprotein B-100 (apo-B) thiols during LDL oxidation.	Sulfhydryl Compounds	92-98	apolipoprotein B	Homo sapiens	63-83
9169017-3	1997	In this report, we have evaluated the antioxidant potential of apolipoprotein B-100 (apo-B) thiols during LDL oxidation.	Sulfhydryl Compounds	92-98	apolipoprotein B	Homo sapiens	85-90
9169017-6	1997	Blocking apo-B thiols with sulfhydryl modifying agents increased the oxidizability of LDL.	Sulfhydryl Compounds	15-21	apolipoprotein B	Homo sapiens	9-14
9169017-6	1997	Blocking apo-B thiols with sulfhydryl modifying agents increased the oxidizability of LDL.	Sulfhydryl Compounds	27-37	apolipoprotein B	Homo sapiens	9-14
9169017-7	1997	As with Cu2+, peroxynitrite also caused depletion of apo-B thiols, and again thiol depletion was inhibited by PBN but not by POBN.	Sulfhydryl Compounds	59-65	apolipoprotein B	Homo sapiens	53-58
9169017-7	1997	As with Cu2+, peroxynitrite also caused depletion of apo-B thiols, and again thiol depletion was inhibited by PBN but not by POBN.	Sulfhydryl Compounds	59-64	apolipoprotein B	Homo sapiens	53-58
9169017-9	1997	We conclude that apo-B thiol depletion is mediated by lipid peroxidation, prior to the onset of the propagation phase of LDL oxidation.	Sulfhydryl Compounds	23-28	apolipoprotein B	Homo sapiens	17-22
9169017-10	1997	The implications of apo-B thiols an intrinsic antioxidants of LDL are discussed.	Sulfhydryl Compounds	26-32	apolipoprotein B	Homo sapiens	20-25
9209680-0	1997	Opposite regulation of tyrosinase and glutathione peroxidase by intracellular thiols in human melanoma cells.	Sulfhydryl Compounds	78-84	tyrosinase	Homo sapiens	23-33
9144160-6	1997	A probable explanation is that MAO-generated H2O2 oxidizes glutathione to glutathione disulfide (GSSG), which undergoes thiol-disulfide interchange to form protein mixed disulfides, thereby interfering reversibly with thiol-dependent enzymatic function.	Sulfhydryl Compounds	218-223	monoamine oxidase A	Rattus norvegicus	31-34
9168998-4	1997	In certain aspects, the plasma membrane-bound ADP-ribosyl cyclase activity resembled the characteristics of CD38 or CD38-like proteins: it was sensitive to thiols and lectins and was recognized by a monoclonal anti CD38 antibody.	Sulfhydryl Compounds	156-162	CD38 molecule	Rattus norvegicus	108-112
9168998-4	1997	In certain aspects, the plasma membrane-bound ADP-ribosyl cyclase activity resembled the characteristics of CD38 or CD38-like proteins: it was sensitive to thiols and lectins and was recognized by a monoclonal anti CD38 antibody.	Sulfhydryl Compounds	156-162	CD38 molecule	Rattus norvegicus	116-120
9168998-4	1997	In certain aspects, the plasma membrane-bound ADP-ribosyl cyclase activity resembled the characteristics of CD38 or CD38-like proteins: it was sensitive to thiols and lectins and was recognized by a monoclonal anti CD38 antibody.	Sulfhydryl Compounds	156-162	CD38 molecule	Rattus norvegicus	116-120
9260870-4	1997	Biochemical experiments showed that (1) BQ was formed by autoxidation of 4-S-CAC as well as by tyrosinase oxidation of 4-S-CAP/4-S-CAC, (2) BQ reacted rapidly with thiols such as reduced glutathione (GSH), and (3) BQ inhibited the activity of alcohol dehydrogenase, an SH enzyme.	Sulfhydryl Compounds	164-170	tyrosinase	Mus musculus	95-105
9260870-4	1997	Biochemical experiments showed that (1) BQ was formed by autoxidation of 4-S-CAC as well as by tyrosinase oxidation of 4-S-CAP/4-S-CAC, (2) BQ reacted rapidly with thiols such as reduced glutathione (GSH), and (3) BQ inhibited the activity of alcohol dehydrogenase, an SH enzyme.	Sulfhydryl Compounds	164-170	aldo-keto reductase family 1, member A1 (aldehyde reductase)	Mus musculus	243-264
9144160-6	1997	A probable explanation is that MAO-generated H2O2 oxidizes glutathione to glutathione disulfide (GSSG), which undergoes thiol-disulfide interchange to form protein mixed disulfides, thereby interfering reversibly with thiol-dependent enzymatic function.	Sulfhydryl Compounds	120-125	monoamine oxidase A	Rattus norvegicus	31-34
9188183-4	1997	Using the acetates and both thiol reagents the absolute configuration of C-2 can be determined, provided it is a hydroxyl group, with great certainty.	Sulfhydryl Compounds	28-33	complement C2	Homo sapiens	73-76
9209680-8	1997	The results indicate that cellular thiols coregulate the activities of tyrosinase and GPO in opposite directions.	Sulfhydryl Compounds	35-41	tyrosinase	Homo sapiens	71-81
9128254-4	1997	The majority of synaptophysin labeled at 18 degrees C with the membrane-impermeant, cleavable sulfo-NHS-SS-biotin was still accessible to extracellularly added MesNa, a 150-D membrane-impermeant thiol-reducing agent, but not to the 68,000-D protein avidin.	Sulfhydryl Compounds	195-200	synaptophysin	Rattus norvegicus	16-29
9129024-0	1997	Thiol-disulfide isomerization in thrombospondin: effects of conformation and protein disulfide isomerase.	Sulfhydryl Compounds	0-5	prolyl 4-hydroxylase subunit beta	Homo sapiens	77-104
9178107-6	1997	The link between cellular production of such important mediators of inflammation and the antioxidant (AO) thiols, cysteine and reduced glutathione (GSH), is discussed and it is hypothesised that NF-kappa B antagonists may offer important therapeutic benefits.	Sulfhydryl Compounds	106-112	nuclear factor kappa B subunit 1	Homo sapiens	195-205
9169621-6	1997	However, we found that alpha2AP incorporates iodo[14C]acetic acid, suggesting that the protein contains reactive thiol groups.	Sulfhydryl Compounds	113-118	serine (or cysteine) peptidase inhibitor, clade F, member 2	Mus musculus	23-31
9130567-0	1997	Thiols decrease human IL-4 production and IL-4-induced immunoglobulin synthesis.	Sulfhydryl Compounds	0-6	interleukin 4	Homo sapiens	22-26
9130567-0	1997	Thiols decrease human IL-4 production and IL-4-induced immunoglobulin synthesis.	Sulfhydryl Compounds	0-6	interleukin 4	Homo sapiens	42-46
9192723-1	1997	We purified and characterized glutaredoxin (thioltransferase), which catalyzes thiol/disulfide exchange reaction, for the first time in plants.	Sulfhydryl Compounds	44-49	glutaredoxin	Homo sapiens	30-42
9168475-4	1997	Redox reagents and an irreversible sulfhydryl-specific cross-linker, bis-maleimidohexane, were used to manipulate the structure of BPTI.	Sulfhydryl Compounds	35-45	spleen trypsin inhibitor I	Bos taurus	131-135
9108029-1	1997	Thioredoxin (TRX) is a pleiotropic cellular factor that has thiol-mediated redox activity and is important in regulation of cellular processes, including proliferation, apoptosis, and gene expression.	Sulfhydryl Compounds	60-65	thioredoxin	Homo sapiens	0-11
9108029-1	1997	Thioredoxin (TRX) is a pleiotropic cellular factor that has thiol-mediated redox activity and is important in regulation of cellular processes, including proliferation, apoptosis, and gene expression.	Sulfhydryl Compounds	60-65	thioredoxin	Homo sapiens	13-16
9132026-4	1997	In order to study directly the relationship between conformational stability and reductive unfolding kinetics, and to gain insight concerning the rate-limiting transition state in the thiol/disulfide-mediated folding/unfolding reaction of BPTI, BPTI variants based on a native-like two-disulfide analog of this intermediate, BPTI(Ala14)Ala38, were examined.	Sulfhydryl Compounds	184-189	spleen trypsin inhibitor I	Bos taurus	239-243
9100033-1	1997	To elucidate how thiols affect neuronal nitric oxide synthase (nNOS) we studied the binding of thiols to tetrahydrobiopterin (BH4)-free nNOS.	Sulfhydryl Compounds	17-23	nitric oxide synthase 1	Homo sapiens	31-61
9100033-1	1997	To elucidate how thiols affect neuronal nitric oxide synthase (nNOS) we studied the binding of thiols to tetrahydrobiopterin (BH4)-free nNOS.	Sulfhydryl Compounds	17-23	nitric oxide synthase 1	Homo sapiens	63-67
9100033-1	1997	To elucidate how thiols affect neuronal nitric oxide synthase (nNOS) we studied the binding of thiols to tetrahydrobiopterin (BH4)-free nNOS.	Sulfhydryl Compounds	95-101	nitric oxide synthase 1	Homo sapiens	63-67
9100033-1	1997	To elucidate how thiols affect neuronal nitric oxide synthase (nNOS) we studied the binding of thiols to tetrahydrobiopterin (BH4)-free nNOS.	Sulfhydryl Compounds	95-101	nitric oxide synthase 1	Homo sapiens	136-140
9100033-14	1997	The stabilization of nNOS by thiols was illustrated by the fact that omission of 2-mercaptoethanol during preincubation for 10 min at 30 degrees C led to an activity decrease of up to 90%.	Sulfhydryl Compounds	29-35	nitric oxide synthase 1	Homo sapiens	21-25
9114980-11	1997	As a consequence, the thiol status of particular tissues may be a contributing factor to individual TDI toxicity susceptibility, and a mechanism by which toxicity at sites distant to the initial point of contact may be proposed.	Sulfhydryl Compounds	22-27	TLX1 neighbor	Homo sapiens	100-103
9114738-6	1997	Ultraviolet A1 radiation-induced expression of intercellular adhesion molecule-1 in KB cells previously was found to depend on the thiol status of these cells.	Sulfhydryl Compounds	131-136	intercellular adhesion molecule 1	Homo sapiens	47-80
9115997-1	1997	The apparent pKa for the active site thiol of human thioltransferase (TTase) is about 3.5, but the pH dependence of TTase-catalyzed rates of glutathione (GSH)-dependent reduction of disulfide substrates displays an inflection point near pH 8.5.	Sulfhydryl Compounds	37-42	glutaredoxin	Homo sapiens	52-68
9115997-1	1997	The apparent pKa for the active site thiol of human thioltransferase (TTase) is about 3.5, but the pH dependence of TTase-catalyzed rates of glutathione (GSH)-dependent reduction of disulfide substrates displays an inflection point near pH 8.5.	Sulfhydryl Compounds	37-42	glutaredoxin	Homo sapiens	70-75
9115997-1	1997	The apparent pKa for the active site thiol of human thioltransferase (TTase) is about 3.5, but the pH dependence of TTase-catalyzed rates of glutathione (GSH)-dependent reduction of disulfide substrates displays an inflection point near pH 8.5.	Sulfhydryl Compounds	37-42	glutaredoxin	Homo sapiens	116-121
9115997-2	1997	The similarity of the pH-rate profile with the titration of the GSH thiol moiety suggested rate-limiting nucleophilic attack by the glutathionyl thiolate species to regenerate reduced TTase from the TTase-SSG intermediate.	Sulfhydryl Compounds	68-73	glutaredoxin	Homo sapiens	184-189
9115997-2	1997	The similarity of the pH-rate profile with the titration of the GSH thiol moiety suggested rate-limiting nucleophilic attack by the glutathionyl thiolate species to regenerate reduced TTase from the TTase-SSG intermediate.	Sulfhydryl Compounds	68-73	glutaredoxin	Homo sapiens	199-204
9115997-6	1997	In addition, second-order rate constants (k) were determined for the nonenzymatic and TTase-catalyzed reactions of the various thiols with BSA-SSG.	Sulfhydryl Compounds	127-133	glutaredoxin	Homo sapiens	86-91
9109401-0	1997	Erythrocyte thiol status regulates band 3 phosphotyrosine level via oxidation/reduction of band 3-associated phosphotyrosine phosphatase.	Sulfhydryl Compounds	12-17	cell division cycle 25C	Homo sapiens	109-136
9109401-3	1997	Here we show that treatment of erythrocytes with the thiol-oxidizing agent diamide leads to the formation of PTP disulfides (PTP-band 3 mixed disulfides) and inhibition of dephosphorylation, allowing the accumulation of band 3 phosphotyrosine.	Sulfhydryl Compounds	53-58	cell division cycle 25C	Homo sapiens	109-112
9109401-3	1997	Here we show that treatment of erythrocytes with the thiol-oxidizing agent diamide leads to the formation of PTP disulfides (PTP-band 3 mixed disulfides) and inhibition of dephosphorylation, allowing the accumulation of band 3 phosphotyrosine.	Sulfhydryl Compounds	53-58	cell division cycle 25C	Homo sapiens	125-128
9109401-5	1997	Erythrocyte thiol alkylation by N-ethylmaleimide results in irreversible PTP inhibition and irreversible phosphorylation.	Sulfhydryl Compounds	12-17	cell division cycle 25C	Homo sapiens	73-76
18634071-1	1997	The major component of the whey fraction of bovine milk, beta-lactoglobulin (betaLG), has been transformed by grafting polyethylene glycol chains either on the thiol group (free and after reduction of the S-S bridges) of the cysteine residues, or on the amino group of the lysine residues and/or of the N-terminal amino acid.	Sulfhydryl Compounds	160-165	beta-lactoglobulin	Bos taurus	57-75
9113368-5	1997	In contrast, pretreatment with the intracellular sulphydryl donor, N-acetyl-L-cysteine (NAC, 1 mM), significantly attenuated GTN-induced tolerance.	Sulfhydryl Compounds	49-59	X-linked Kx blood group	Homo sapiens	88-91
9108299-6	1997	Comparison of the amino acid sequence of human cathepsin W with other human thiol-dependent cathepsins revealed a relatively low degree of similarity (21-31%).	Sulfhydryl Compounds	76-81	cathepsin W	Homo sapiens	47-58
9120263-0	1997	Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.	Sulfhydryl Compounds	170-175	thioredoxin	Homo sapiens	0-42
9120263-0	1997	Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state.	Sulfhydryl Compounds	170-175	thioredoxin	Homo sapiens	49-60
9089334-7	1997	Using molecular modeling, it was predicted that the Cys side chains in erbB-1 and erbB-2 performed an analogous role, and it was postulated that the replacement of the 2"-OH of adenosine with a thiol might allow for a covalent bond to form.	Sulfhydryl Compounds	194-199	epidermal growth factor receptor	Homo sapiens	71-77
9089334-7	1997	Using molecular modeling, it was predicted that the Cys side chains in erbB-1 and erbB-2 performed an analogous role, and it was postulated that the replacement of the 2"-OH of adenosine with a thiol might allow for a covalent bond to form.	Sulfhydryl Compounds	194-199	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-88
9132026-4	1997	In order to study directly the relationship between conformational stability and reductive unfolding kinetics, and to gain insight concerning the rate-limiting transition state in the thiol/disulfide-mediated folding/unfolding reaction of BPTI, BPTI variants based on a native-like two-disulfide analog of this intermediate, BPTI(Ala14)Ala38, were examined.	Sulfhydryl Compounds	184-189	spleen trypsin inhibitor I	Bos taurus	245-249
9132026-4	1997	In order to study directly the relationship between conformational stability and reductive unfolding kinetics, and to gain insight concerning the rate-limiting transition state in the thiol/disulfide-mediated folding/unfolding reaction of BPTI, BPTI variants based on a native-like two-disulfide analog of this intermediate, BPTI(Ala14)Ala38, were examined.	Sulfhydryl Compounds	184-189	spleen trypsin inhibitor I	Bos taurus	245-249
9013575-12	1997	Thiol reagents and oxidative stress may modify two thiol groups on the ANT and thus stimulate pore opening by both means.	Sulfhydryl Compounds	0-5	solute carrier family 25 member 6	Homo sapiens	71-74
9073589-5	1997	These results suggest that p-BQ inhibits T-cell mitogenesis by blocking a thiol-dependent event that controls IL-2 production but not other T-cell activation events.	Sulfhydryl Compounds	74-79	interleukin 2	Homo sapiens	110-114
9125187-1	1997	In higher plants, light enhances the activity of chloroplast fructose-1,6-bisphosphatase via a cascade of thiol/disulfide exchanges.	Sulfhydryl Compounds	106-111	fructose-1,6-bisphosphatase, cytosolic	Brassica napus	61-88
9250393-0	1997	The molecular response to reductive stress in LLC-PK1 renal epithelial cells: coordinate transcriptional regulation of gadd153 and grp78 genes by thiols.	Sulfhydryl Compounds	146-152	heat shock protein family A (Hsp70) member 5	Sus scrofa	131-136
9250393-2	1997	Treatment of cells with thiols activates expression of grp78, but it is not known if, like other forms of stress, there is a battery of stress response genes that are induced by thiols.	Sulfhydryl Compounds	24-30	heat shock protein family A (Hsp70) member 5	Sus scrofa	55-60
9250393-3	1997	In LLC-PK1 renal epithelial cells, mRNAs for both grp78 and gadd153 were induced by thiols with similar time, concentration and structure-activity dependence.	Sulfhydryl Compounds	84-90	heat shock protein family A (Hsp70) member 5	Sus scrofa	50-55
9046331-9	1997	The sulfhydryl reducing agent dithiothreitol (DTT) caused a general decrease in inhibition of the EGFr and v-src tyrosine kinases by both the diselenium and disulfur series with the reversal of enzyme inhibition occurring less readily within the diselenium series.	Sulfhydryl Compounds	4-14	epidermal growth factor receptor	Mus musculus	98-102
9013575-12	1997	Thiol reagents and oxidative stress may modify two thiol groups on the ANT and thus stimulate pore opening by both means.	Sulfhydryl Compounds	51-56	solute carrier family 25 member 6	Homo sapiens	71-74
9054621-5	1997	Finally, depletion of intracellular thiol levels by smoke-bubbled PBS appears to favour the activation of a redox-sensitive component of the c-fos-inducing pathway.	Sulfhydryl Compounds	36-41	FBJ osteosarcoma oncogene	Mus musculus	141-146
9059983-7	1997	Our studies further reveal that hepatic flavokinase appears to contain an essential, accessible and functional thiol group(s) which is evident from a concentration dependent inhibition of activity by sulfhydryl reagents like parachloromercuribenzoate (PCMB), 5,5"-dithiobis (2-nitrobenzoic acid) (DTNB), and N-ethylmaleimide (NEM).	Sulfhydryl Compounds	111-116	dystrobrevin, beta	Rattus norvegicus	297-301
9041453-1	1997	To identify regions of the ryanodine receptor (RyR) important for ion conduction we modified the channel with sulfhydryl-reacting compounds.	Sulfhydryl Compounds	110-120	ryanodine receptor 1	Homo sapiens	27-45
9041453-1	1997	To identify regions of the ryanodine receptor (RyR) important for ion conduction we modified the channel with sulfhydryl-reacting compounds.	Sulfhydryl Compounds	110-120	ryanodine receptor 1	Homo sapiens	47-50
9076692-4	1997	It is reasonable to consider that the cysteine-penicillamine disulfide is continuing to be enzymatically reduced by various thiol reductants, in particular glutathione reductase, thereby generating a "new" penicillamine molecule which, in turn, reacts with other cystine disulfides and does so in an unending cycle.	Sulfhydryl Compounds	124-129	glutathione-disulfide reductase	Homo sapiens	156-177
8995435-1	1997	A lymphocyte-specific murine Ltk tyrosine kinase isoform was previously found to reside in the endoplasmic reticulum and to be potently activated upon treatment of cells with alkylating or thiol-oxidizing agents.	Sulfhydryl Compounds	189-194	leukocyte tyrosine kinase	Mus musculus	29-32
9381987-5	1997	Conjugate was prepared by derivatizing the enzyme and monoclonal antibody KS1/4 with linkers containing maleimide and sulfhydryl groups, respectively; interaction of these groups to form a stable thioether bond joined the proteins.	Sulfhydryl Compounds	118-128	epithelial cell adhesion molecule	Homo sapiens	74-79
8895810-1	1997	The diversity of application of the thiol drug NAC in both the experimental setting, as a tool for the study of the mechanisms and consequences of oxidative stress, and the clinical setting, as a therapeutic agent, clearly reflects the central role played by the redox chemistries of the group XVI elements, oxygen and sulfur, in biology.	Sulfhydryl Compounds	36-41	synuclein alpha	Homo sapiens	47-50
9038816-2	1997	We have previously shown that NO inhibits GAPDH by S-nitrosylation of the active site cysteine residue, which is reversed by low-molecular-weight thiols.	Sulfhydryl Compounds	146-152	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	42-47
9038816-5	1997	The mechanism for inhibition appears to involve reversible modification of GAPDH because addition of thiols to cell extracts restored activity.	Sulfhydryl Compounds	101-107	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	75-80
9003420-4	1997	Preincubation with thiol reagents such as p-chloromercuribenzoate, N-ethylmaleimide, iodoacetate and 5,5"-dithiobis-(2-nitrobenzoate) resulted in significant inhibition of recombinant human glutathione synthase.	Sulfhydryl Compounds	19-24	glutathione synthetase	Homo sapiens	190-210
14646567-0	1997	Activation of a CPP32-like protease during L1210 cell apoptosis induced by thiol deprivation.	Sulfhydryl Compounds	75-80	caspase 3	Mus musculus	16-21
14646567-4	1997	A specific inhibitor of interleukin-1 beta-converting enzyme (ICE)-like and CPP32-like proteases could suppress L1210 cell apoptosis induced by thiol deprivation.	Sulfhydryl Compounds	144-149	caspase 1	Mus musculus	24-60
14646567-4	1997	A specific inhibitor of interleukin-1 beta-converting enzyme (ICE)-like and CPP32-like proteases could suppress L1210 cell apoptosis induced by thiol deprivation.	Sulfhydryl Compounds	144-149	caspase 1	Mus musculus	62-65
14646567-4	1997	A specific inhibitor of interleukin-1 beta-converting enzyme (ICE)-like and CPP32-like proteases could suppress L1210 cell apoptosis induced by thiol deprivation.	Sulfhydryl Compounds	144-149	caspase 3	Mus musculus	76-81
14646567-6	1997	The addition of thiols could suppress CPP32-like protease activation.	Sulfhydryl Compounds	16-22	caspase 3	Mus musculus	38-43
14646567-7	1997	Although the cell death-suppressor bcl-2-family proteins (bcl-2 and bcl-XL) were recently found to suppress the activation of CPP32-like proteases, the expression levels of death-suppressor bcl-2-family proteins did not change when thiols were added.	Sulfhydryl Compounds	232-238	B cell leukemia/lymphoma 2	Mus musculus	35-40
14646567-7	1997	Although the cell death-suppressor bcl-2-family proteins (bcl-2 and bcl-XL) were recently found to suppress the activation of CPP32-like proteases, the expression levels of death-suppressor bcl-2-family proteins did not change when thiols were added.	Sulfhydryl Compounds	232-238	B cell leukemia/lymphoma 2	Mus musculus	58-63
14646567-7	1997	Although the cell death-suppressor bcl-2-family proteins (bcl-2 and bcl-XL) were recently found to suppress the activation of CPP32-like proteases, the expression levels of death-suppressor bcl-2-family proteins did not change when thiols were added.	Sulfhydryl Compounds	232-238	BCL2-like 1	Mus musculus	68-74
14646567-7	1997	Although the cell death-suppressor bcl-2-family proteins (bcl-2 and bcl-XL) were recently found to suppress the activation of CPP32-like proteases, the expression levels of death-suppressor bcl-2-family proteins did not change when thiols were added.	Sulfhydryl Compounds	232-238	B cell leukemia/lymphoma 2	Mus musculus	58-63
14646567-8	1997	These results suggest that reduced thiols maintain L1210 cell survival by inhibiting the activation of CPP32-like proteases without changing the anti-apoptotic bcl-2-family protein expression.	Sulfhydryl Compounds	35-41	caspase 3	Mus musculus	103-108
9030406-4	1997	A Glu-thiol inhibitor of aminopeptidase A also reduced angiotensin II-induced drinking.	Sulfhydryl Compounds	6-11	glutamyl aminopeptidase	Homo sapiens	25-41
9030406-4	1997	A Glu-thiol inhibitor of aminopeptidase A also reduced angiotensin II-induced drinking.	Sulfhydryl Compounds	6-11	angiotensinogen	Homo sapiens	55-69
9056074-11	1997	in the presence of O2 formed nitrosylated cysteine followed by the transnitrosation of regulatory thiols on the RyR to activate the channel.	Sulfhydryl Compounds	98-104	ryanodine receptor 2	Homo sapiens	112-115
9588817-6	1997	Externally added thiols (glutathione, GSH; D-Penicillamine, DP; N-acetylcysteine, NAC) protected EC from damage of cGMP production and cell detachment.	Sulfhydryl Compounds	17-23	synuclein alpha	Homo sapiens	82-85
9074802-6	1997	Addition of thiol-containing polymers (bovine serum albumin or thiol-agarose chromatographic beads) had a minimal effect on MN oxidation by TPO, but substantially reduced product formation and produced concomitant losses in free thiols.	Sulfhydryl Compounds	12-17	thyroid peroxidase	Homo sapiens	140-143
9010626-5	1997	Apoferritin (a thiol-containing protein), native microsomes, and, to a lesser extent, boiled microsomes catalyze the reaction.	Sulfhydryl Compounds	15-20	ferritin heavy chain 1	Homo sapiens	0-11
9588818-6	1997	The sulphydryl-containing ACE inhibitors captopril and zofenaprilat enhanced early LV relaxation, whereas the non-sulphydryl-containing ACE inhibitors lisinopril and quinaprilat did not.	Sulfhydryl Compounds	4-14	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	26-29
9040542-7	1997	Splenocytes from LP mice were significantly lower in number and had a lower intracellular GSH concentration, depressed CD3-stimulated T-lymphocyte proliferation in culture media without thiol supplementation (2-mercaptoethanol), and enhanced CD3-stimulated proliferation in thiol-supplemented culture media compared with splenocytes from CP mice.	Sulfhydryl Compounds	274-279	CD3 antigen, epsilon polypeptide	Mus musculus	119-122
9165302-5	1997	Biochemical analysis revealed that, during the perinatal period, hepatic GGT levels transiently increased predominantly with hepatocytes, suggesting a marked change in thiol status in and around these cells.	Sulfhydryl Compounds	168-173	gamma-glutamyltransferase 1	Rattus norvegicus	73-76
9199883-0	1997	Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzyme.	Sulfhydryl Compounds	138-144	cathepsin B	Mus musculus	16-27
9199883-10	1997	These data suggest that aldehydic adducts on ox-LDL that are unreactive at neutral pH, possibly HNE bound to apo B, become exposed at acidic pH and then covalently bind thiols on neighboring proteins such as cathepsin B in lysosomes, inducing crosslinking of proteins and enzyme inactivation.	Sulfhydryl Compounds	169-175	cathepsin B	Mus musculus	208-219
9043953-0	1997	Thiol-mediated inhibition of FAS and CD2 apoptotic signaling in activated human peripheral T cells.	Sulfhydryl Compounds	0-5	CD2 molecule	Homo sapiens	37-40
9040542-9	1997	Within 1 wk of dietary repletion, splenocyte GSH concentration was normal and splenocyte numbers were greater, and in vitro sensitivity of CD3-stimulated T-lymphocyte proliferation to thiol was lower, compared with LP mice.	Sulfhydryl Compounds	184-189	CD3 antigen, epsilon polypeptide	Mus musculus	139-142
9266428-10	1997	We also found that expression of bcl-2 can inhibit the decrease in intracellular reduced thiol (-SH) groups which we observed following exposure to DA.	Sulfhydryl Compounds	89-94	BCL2, apoptosis regulator	Rattus norvegicus	33-38
9040542-10	1997	Glutathione status in vivo and thiol supplementation in vitro seem to modulate the signal transduction pathway for T-lymphocyte proliferation in mice with PEM.	Sulfhydryl Compounds	31-36	reproductive homeobox 5	Mus musculus	155-158
9021762-3	1997	The activity was thiol and metal dependent, with a similar inhibition profile to insulin-degrading enzyme.	Sulfhydryl Compounds	17-22	insulin degrading enzyme	Rattus norvegicus	81-105
9011676-1	1997	Human thioredoxin is a polypeptide with thiol groups, possessing reducing activity, which is proved to have the ability to reduce active oxygens.	Sulfhydryl Compounds	40-45	thioredoxin	Homo sapiens	6-17
9232906-0	1997	Cloning of the cDNA for glutaredoxin, an abundant sieve-tube exudate protein from Ricinus communis L. and characterisation of the glutathione-dependent thiol-reduction system in sieve tubes.	Sulfhydryl Compounds	152-157	glutaredoxin	Ricinus communis	24-36
9290121-5	1997	Measurement of acid-soluble free sulfhydryl groups showed an initial increase in response to SAMC followed by a progressive dose-dependent decrease with extended incubation of cells.	Sulfhydryl Compounds	33-43	solute carrier family 25 member 26	Homo sapiens	93-97
9232906-8	1997	Glutathione, which is the obligate donor of reduced thiols for glutaredoxin, was present in sieve-tube sap in millimolar concentrations (up to 3 mM) with a ratio of total to oxidised glutathione of 3:1.	Sulfhydryl Compounds	52-58	glutaredoxin	Homo sapiens	63-75
8960150-8	1996	In addition, the extent of thiol modification of carbonic anhydrase III, as determined by combining isoelectric focusing analysis with immunoblotting, further demonstrated that alpha-tocopherol helps maintain protein thiols in the reduced state.	Sulfhydryl Compounds	27-32	carbonic anhydrase 3	Rattus norvegicus	49-71
9151381-2	1997	TRX/ADF is a potent thiol-related reducing agent, acts as a redox regulator, and it can attenuate the induction of apoptosis of T lineage lymphocytes.	Sulfhydryl Compounds	20-25	thioredoxin	Homo sapiens	0-3
9151381-2	1997	TRX/ADF is a potent thiol-related reducing agent, acts as a redox regulator, and it can attenuate the induction of apoptosis of T lineage lymphocytes.	Sulfhydryl Compounds	20-25	thioredoxin	Homo sapiens	4-7
9000632-14	1996	However, the electron density corresponding to the sulfur of the Cys181 side-chain in the p66 subunit is very weak, indicating that the thiol group is disordered, presumably because there is no significant interaction with either 8-Cl TIBO or nearby amino acid residues.	Sulfhydryl Compounds	136-141	DNA polymerase delta 3, accessory subunit	Homo sapiens	90-93
8960150-8	1996	In addition, the extent of thiol modification of carbonic anhydrase III, as determined by combining isoelectric focusing analysis with immunoblotting, further demonstrated that alpha-tocopherol helps maintain protein thiols in the reduced state.	Sulfhydryl Compounds	217-223	carbonic anhydrase 3	Rattus norvegicus	49-71
8973191-16	1996	Thiol oxidation, S-nitroso thiol formation, and zinc release correlated with inactivation of ADH by NO, indicating that disruption of the zinc/thiolate active center due to S nitrosylation of ADH results in zinc release, followed by inactivation of the enzyme.	Sulfhydryl Compounds	0-5	aldo-keto reductase family 1 member A1	Rattus norvegicus	93-96
8943303-1	1996	Tissue transglutaminase (TGase II) is a Ca2+- and thiol-dependent enzyme that catalyzes the post-translational modification of proteins via the formation of epsilon(gamma-glutamyl) lysine bonds.	Sulfhydryl Compounds	50-55	transglutaminase 2	Homo sapiens	0-23
9003388-6	1996	These results suggested that the inhibition was caused by oxidation of NF kappa B on a sensitive thiol, possibly on the p50 subunit (which was detected in NF kappa B complexes in both cell types), and not by inhibition of the activation pathway.	Sulfhydryl Compounds	97-102	nuclear factor kappa B subunit 1	Homo sapiens	71-81
8943311-14	1996	Deacylation of affinity-purified ASGP-Rs with hydroxylamine results in the spontaneous formation of dimers through reversible disulfide bonds, indicating that deacylation concomitantly generates free thiol groups.	Sulfhydryl Compounds	200-205	mucin 4, cell surface associated	Rattus norvegicus	33-37
9003392-5	1996	This study was undertaken to determine whether important endogenous and pharmacological thiols modulate the activation of NF-kappa B and the release of tumour necrosis factor alpha (TNF-alpha) from Kupffer cells and to ascertain whether these effects are mediated through glutathione.	Sulfhydryl Compounds	88-94	tumor necrosis factor	Rattus norvegicus	182-191
8981751-1	1996	The xanthene probes 5"-iodoacetamido-fluorescein and -tetramethylrhodamine specifically modify skeletal muscle myosin subfragment 1 (S1) at the reactive thiol residue (SH1) and fully quench the fluorescence emission from tryptophan residue 510 (Trp510) in S1 (T.P.	Sulfhydryl Compounds	153-158	myosin heavy chain 14	Homo sapiens	111-117
8961948-0	1996	Thiol oxidation and cytochrome P450-dependent metabolism of CCl4 triggers Ca2+ release from liver microsomes.	Sulfhydryl Compounds	0-5	C-C motif chemokine ligand 4	Rattus norvegicus	60-64
8961948-11	1996	Lipophilic thiols such as mercaptoethanol or cysteamine could partially reverse the CCl4-induced calcium release, whereas GSH was ineffective.	Sulfhydryl Compounds	11-17	C-C motif chemokine ligand 4	Rattus norvegicus	84-88
8961948-15	1996	These results suggest that metabolism of CCl4 to reactive species by cytochrome P450 results in an activation of a ryanodine-sensitive calcium channel, perhaps due to oxidation of lipophilic thiols of the channel.	Sulfhydryl Compounds	191-197	C-C motif chemokine ligand 4	Rattus norvegicus	41-45
8977294-0	1996	Thiols prevent Fas (CD95)-mediated T cell apoptosis by down-regulating membrane Fas expression.	Sulfhydryl Compounds	0-6	Fas cell surface death receptor	Homo sapiens	20-24
9015404-11	1996	CONCLUSIONS: These results suggest that inhibition of GAPDH activity may represent an important point at which glycolysis is limited during reperfusion, and further, that the mechanisms of enzyme inhibition do not involve simple oxidation or S-thiolation of critical active site thiol groups.	Sulfhydryl Compounds	244-249	glyceraldehyde-3-phosphate dehydrogenase	Canis lupus familiaris	54-59
8986633-6	1996	Furthermore, in agreement with kinetic and structural information, PHGPx-chromatin binding could suggest an hypothetical thiol oxidase activity toward specific thiol bearing proteins which could substitute for GSH as alternative donor substrates.	Sulfhydryl Compounds	121-126	glutathione peroxidase 4	Homo sapiens	67-72
8951240-5	1996	Among them, GSH and Cys conjugates of MC-RR were identified at 3 and 24 h, respectively, by comparison with the chemically prepared standards, indicating that the thiols of GSH and Cys nucleophilically bound to the Mdha moiety of MCs.	Sulfhydryl Compounds	163-169	malate dehydrogenase 1, NAD (soluble)	Mus musculus	215-219
8975783-10	1996	Pretreatment with 50 mM N-acetyl-L-cysteine (NAC), a sulfhydryl donor and antioxidant, nearly eliminated the apoptotic features of cell death but did not prevent necrosis in response to SM.	Sulfhydryl Compounds	53-63	X-linked Kx blood group	Homo sapiens	45-48
9052856-1	1996	Adult T-cell leukemia derived factor (ADF)/human thioredoxin (TRX), which has thiol reducing and radical scavenging activities, plays an essential role on cellular protection against oxidative stress and cell death.	Sulfhydryl Compounds	78-83	thioredoxin	Homo sapiens	38-41
9052856-1	1996	Adult T-cell leukemia derived factor (ADF)/human thioredoxin (TRX), which has thiol reducing and radical scavenging activities, plays an essential role on cellular protection against oxidative stress and cell death.	Sulfhydryl Compounds	78-83	thioredoxin	Homo sapiens	49-60
9052856-1	1996	Adult T-cell leukemia derived factor (ADF)/human thioredoxin (TRX), which has thiol reducing and radical scavenging activities, plays an essential role on cellular protection against oxidative stress and cell death.	Sulfhydryl Compounds	78-83	thioredoxin	Homo sapiens	62-65
9195485-5	1996	It is also shown that one of four thiols in soybean lipoxygenase-1 is accessible to DTNB at 0.1% SDS without losing great activity, and that all four thiols are accessible to DTNB at 1% SDS and lose all activity.	Sulfhydryl Compounds	34-40	seed linoleate 13S-lipoxygenase-1	Glycine max	52-66
8952706-5	1996	These results suggest that the increase in cytosolic Ca2+ is related to depletion of SH-groups, but independent of lipid peroxidation, whereas inhibition of PKC may be associated with cisplatin-induced depletion of thiols and with lipid peroxidation.	Sulfhydryl Compounds	215-221	protein kinase C, gamma	Rattus norvegicus	157-160
8955366-4	1996	Increases of 3- to 4-fold in the oxidation constants for both S-adenosylmethionine synthetase isoenzymes in the presence of protein disulfide isomerase suggested the possibility of a thiol-disulfide exchange regulatory mechanism for this enzyme in vivo.	Sulfhydryl Compounds	183-188	methionine adenosyltransferase 1A	Rattus norvegicus	62-93
8901910-1	1996	Reactions of ethenyloxirane with amino (RNH2) and thiol (R"SH) nucleophiles occur by an SN2 mechanism involving competing ring cleavage at C-2 and C-3.	Sulfhydryl Compounds	50-55	complement C2	Homo sapiens	139-150
8914924-14	1996	The enzyme inhibition seems to involve the oxidation of the thiol group of PTPs.	Sulfhydryl Compounds	60-65	6-pyruvoyl-tetrahydropterin synthase	Rattus norvegicus	75-79
8929552-4	1996	Quantification of surface thiols on resting lymphocytes revealed that some subsets expressed different concentrations of surface thiols (CD19+ &gt; CD8+ &gt; CD4+).	Sulfhydryl Compounds	129-135	CD19 molecule	Homo sapiens	137-141
8929552-4	1996	Quantification of surface thiols on resting lymphocytes revealed that some subsets expressed different concentrations of surface thiols (CD19+ &gt; CD8+ &gt; CD4+).	Sulfhydryl Compounds	129-135	CD8a molecule	Homo sapiens	148-151
8929552-4	1996	Quantification of surface thiols on resting lymphocytes revealed that some subsets expressed different concentrations of surface thiols (CD19+ &gt; CD8+ &gt; CD4+).	Sulfhydryl Compounds	129-135	CD4 molecule	Homo sapiens	158-161
8929552-8	1996	Lymphocytes from HIV-infected individuals displayed increased surface thiols on CD19+ and CD4+ cells but not CD8+ cells.	Sulfhydryl Compounds	70-76	CD19 molecule	Homo sapiens	80-84
8929552-8	1996	Lymphocytes from HIV-infected individuals displayed increased surface thiols on CD19+ and CD4+ cells but not CD8+ cells.	Sulfhydryl Compounds	70-76	CD4 molecule	Homo sapiens	90-93
8931546-2	1996	This is believed to be regulated not by varying the disulfide bond itself, but by modulating the stability of the dithiol form of the protein through interactions with the ionized form of the Cys1 thiol group.	Sulfhydryl Compounds	116-121	cystin 1	Homo sapiens	192-196
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	68-73	cystin 1	Homo sapiens	63-67
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	68-73	thioredoxin	Homo sapiens	108-119
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	68-73	thioredoxin	Homo sapiens	140-151
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	68-73	prolyl 4-hydroxylase subunit beta	Homo sapiens	167-194
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	68-73	prolyl 4-hydroxylase subunit beta	Homo sapiens	196-201
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	225-230	cystin 1	Homo sapiens	63-67
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	225-230	thioredoxin	Homo sapiens	108-119
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	225-230	thioredoxin	Homo sapiens	140-151
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	225-230	prolyl 4-hydroxylase subunit beta	Homo sapiens	167-194
8931546-3	1996	A consistent relationship between disulfide bond stability and Cys1 thiol pKa value is found here for DsbA, thioredoxin, and the N-terminal thioredoxin-like domain of protein disulfide isomerase (PDI a), which has a very low thiol pKa value of 4.5.	Sulfhydryl Compounds	225-230	prolyl 4-hydroxylase subunit beta	Homo sapiens	196-201
8896429-2	1996	The PLA1 epitope on platelet GPIIIa has a sulfhydryl-dependent conformation and is dependent on a leucine 33/proline33 polymorphism.	Sulfhydryl Compounds	42-52	POU class 2 homeobox 3	Homo sapiens	4-8
8896429-2	1996	The PLA1 epitope on platelet GPIIIa has a sulfhydryl-dependent conformation and is dependent on a leucine 33/proline33 polymorphism.	Sulfhydryl Compounds	42-52	integrin subunit beta 3	Homo sapiens	29-35
8906874-0	1996	Metal-catalyzed inactivation of bovine glucose-6-phosphate dehydrogenase--role of thiols.	Sulfhydryl Compounds	82-88	glucose-6-phosphate dehydrogenase	Bos taurus	39-72
8906874-1	1996	The role of thiols as oxidant scavengers during inactivation of bovine glucose-6-phosphate dehydrogenase by metal-catalyzed oxidation systems has been studied in vitro.	Sulfhydryl Compounds	12-18	glucose-6-phosphate dehydrogenase	Bos taurus	71-104
8906874-7	1996	It is therefore concluded that the nature of the chelator as a constituent of the metal-catalyzed oxidation systems determines whether the antioxidative function of some thiols is shifted to a prooxidative function against glucose-6-phosphate dehydrogenase.	Sulfhydryl Compounds	170-176	glucose-6-phosphate dehydrogenase	Bos taurus	223-256
8912669-3	1996	We performed spin-trapping studies with purified apo-GAPDH to identify a putative thiol intermediate produced by AAPH as well as by .NO-related oxidants.	Sulfhydryl Compounds	82-87	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	53-58
8912669-1	1996	Previous studies have demonstrated that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes NAD(H) linkage to an active site thiol when it comes into contact with .NO-related oxidants.	Sulfhydryl Compounds	132-137	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	40-80
8897815-5	1996	Reversal of SIN-1 inhibition of glucose-stimulated insulin release by dithiothreitol suggests that NO may inhibit insulin secretion partly by S-nitrosylation of thiol residues in key proteins in the stimulus-secretion coupling.	Sulfhydryl Compounds	161-166	insulin	Homo sapiens	114-121
8912669-1	1996	Previous studies have demonstrated that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes NAD(H) linkage to an active site thiol when it comes into contact with .NO-related oxidants.	Sulfhydryl Compounds	132-137	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	82-87
8810268-8	1996	The expression of YHB1 in aerobic cells is enhanced in the presence of antimycin A, in thiol oxidants, or in strains that lack superoxide dismutase.	Sulfhydryl Compounds	87-92	flavohemoglobin	Saccharomyces cerevisiae S288C	18-22
8805661-7	1996	Expression of baboon CR1b yielded a membrane protein that reacted with an anti-CR1 mAb, was identical in size to baboon E-CR, and, like baboon E-CR, could bind baboon C3 linked to activated thiol-Sepharose (C3i-ATS), but not human C3i-ATS.	Sulfhydryl Compounds	190-195	LOW QUALITY PROTEIN: complement receptor type 1	Papio anubis	21-24
8897815-5	1996	Reversal of SIN-1 inhibition of glucose-stimulated insulin release by dithiothreitol suggests that NO may inhibit insulin secretion partly by S-nitrosylation of thiol residues in key proteins in the stimulus-secretion coupling.	Sulfhydryl Compounds	161-166	MAPK associated protein 1	Homo sapiens	12-17
20650237-4	1996	Carbonic anhydrase III (CA III) having two reactive thiols that can react with GSH under oxidative stress was chosen as the study subject.	Sulfhydryl Compounds	52-58	carbonic anhydrase 3	Rattus norvegicus	0-22
20650237-4	1996	Carbonic anhydrase III (CA III) having two reactive thiols that can react with GSH under oxidative stress was chosen as the study subject.	Sulfhydryl Compounds	52-58	carbonic anhydrase 3	Rattus norvegicus	24-30
20650237-6	1996	Results indicated that thiol modification of CA III was induced by t-BuOOH and the pattern of modification was dependent on the vitamin E status.	Sulfhydryl Compounds	23-28	carbonic anhydrase 3	Rattus norvegicus	45-51
8823182-1	1996	Thirty consecutive single cysteine substitution mutants in the amino acids Q225-I256 of bovine rhodopsin have been prepared and modified with a sulfhydryl specific nitroxide reagent.	Sulfhydryl Compounds	144-154	rhodopsin	Bos taurus	95-104
8805638-4	1996	The thiol antioxidants N-acetyl cysteine and glutathione blocked Fas-induced death triggered via cross-linking either by IgM anti-Fas or cell-bound FasL, while the other inhibitors of activation-induced death did not block this late lethal step.	Sulfhydryl Compounds	4-9	Fas ligand	Homo sapiens	148-152
8870684-12	1996	We demonstrated that a reaction between MSu and an alternative thiol such as L-cysteine or 2-mercaptoethanol can take place in the presence of S-methylglutathione and GSTT2-2.	Sulfhydryl Compounds	63-68	glutathione S-transferase theta 2 (gene/pseudogene)	Homo sapiens	167-174
8891908-0	1996	Mercuric chloride mediates a protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase which is independent of the phosphorylation/dephosphorylation of a carboxyl terminal tyrosine.	Sulfhydryl Compounds	37-47	Rous sarcoma oncogene	Mus musculus	113-116
8891908-7	1996	These results suggest a unique protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase in NIH3T3 cells.	Sulfhydryl Compounds	39-49	Rous sarcoma oncogene	Mus musculus	115-118
8816464-7	1996	Inhibition of thiol-mediated intermolecular disulfide bonding prevented delta-Ron oligomerization.	Sulfhydryl Compounds	14-19	macrophage stimulating 1 receptor	Homo sapiens	78-81
8925922-0	1996	Activation-independent nuclear translocation of mitogen activated protein kinase ERK1 mediated by thiol-modifying chemicals.	Sulfhydryl Compounds	98-103	mitogen-activated protein kinase 3	Homo sapiens	81-85
8925922-4	1996	Using indirect immunofluorescence and biochemical analysis we show that ERK1 can translocate to the nucleus in the absence of activation and phosphorylation by upstream kinases when cells are treated with thiol-modifying chemicals.	Sulfhydryl Compounds	205-210	mitogen-activated protein kinase 3	Homo sapiens	72-76
8794887-9	1996	The results suggest that D-penicillamine is distinguished from other thiols by its formation of sulfur-containing radicals capable of inhibiting AP-1 DNA binding by a mechanism involving the cysteine residues of Jun and Fos.	Sulfhydryl Compounds	69-75	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-149
8902616-6	1996	Taking account of the results of the structural analysis, we conclude that one of the functions of PDI in vivo lies in relaxing the structure around the disulfide bond, as well as in exchanging the thiol-disulfide bonds.	Sulfhydryl Compounds	198-203	prolyl 4-hydroxylase subunit beta	Homo sapiens	99-102
8930128-1	1996	Modification of protein thiol by mixed disulfide formation with low molecular weight cellular thiols has been proposed as one of the post-translational modifications of amino acid side chains and is known to be catalyzed by thioltransferase.	Sulfhydryl Compounds	24-29	glutaredoxin	Homo sapiens	224-240
8930128-1	1996	Modification of protein thiol by mixed disulfide formation with low molecular weight cellular thiols has been proposed as one of the post-translational modifications of amino acid side chains and is known to be catalyzed by thioltransferase.	Sulfhydryl Compounds	94-100	glutaredoxin	Homo sapiens	224-240
8794470-4	1996	The results suggest that reaction of the iminium bond in the benzophenanthridine molecule with thiol groups of the enzyme participates in GAD inhibition.	Sulfhydryl Compounds	95-100	glutamate-ammonia ligase	Rattus norvegicus	138-141
8765220-0	1996	Cleft containing reactive thiol of myosin closes during ATP hydrolysis.	Sulfhydryl Compounds	26-31	myosin heavy chain 14	Homo sapiens	35-41
8765220-1	1996	The probe binding cleft of myosin subfragment 1 (S1) contains the reactive thiol, SH1, and tryptophan 510 (Trp-510).	Sulfhydryl Compounds	75-80	myosin heavy chain 14	Homo sapiens	27-33
8885336-0	1996	Human (THP-1) macrophages oxidize LDL by a thiol-dependent mechanism.	Sulfhydryl Compounds	43-48	GLI family zinc finger 2	Homo sapiens	7-12
8893268-1	1996	PURPOSE: To clarify the mechanism of covalent binding between human serum albumin (HSA) and drugs containing thiol groups, we studied the interactions between HSA and bucillamine (BA) and its derivatives.	Sulfhydryl Compounds	109-114	albumin	Homo sapiens	68-81
8756708-7	1996	It still catalyzes only a subset of the thiol/disulfide exchange reactions of intact PDI and has a reduced ability to catalyze protein disulfide rearrangements.	Sulfhydryl Compounds	40-45	prolyl 4-hydroxylase subunit beta	Homo sapiens	85-88
8811836-3	1996	A series of chromatographic steps (DEAE-Sepharose, Sephacryl S-200 and Activated Thiol Sepharose 4B) generated a soluble PAP activity purified to near homogeneity with a total active yield of 6.6% The enzyme displayed a native molecular mass of approximately 23,700 Da, which compares well with that value obtained under denaturing conditions via SDS-PAGE (24,000 Da), suggesting that the enzyme exists as a monomer.	Sulfhydryl Compounds	81-86	PDGFA associated protein 1	Homo sapiens	121-124
8811836-4	1996	The expression of PAP activity displayed an absolute requirement for the presence of a disulphide bond-reducing agent such as DTT, whilst optimum activity was observed at pH 8.5. strong inhibition of PAP activity was observed with a number of different agents, including transition metal ions, sulphydryl-blocking agents and 2-pyrrolidone (a pGlu analog).	Sulfhydryl Compounds	294-304	PDGFA associated protein 1	Homo sapiens	18-21
8811836-4	1996	The expression of PAP activity displayed an absolute requirement for the presence of a disulphide bond-reducing agent such as DTT, whilst optimum activity was observed at pH 8.5. strong inhibition of PAP activity was observed with a number of different agents, including transition metal ions, sulphydryl-blocking agents and 2-pyrrolidone (a pGlu analog).	Sulfhydryl Compounds	294-304	PDGFA associated protein 1	Homo sapiens	200-203
8889834-0	1996	Reversible affinity labeling of opioid receptors via disulfide bonding: discriminative labeling of mu and delta subtypes by chemically activated thiol-containing enkephalin analogs.	Sulfhydryl Compounds	145-150	proenkephalin	Rattus norvegicus	162-172
8683729-7	1996	RESULTS: Both PRL and GH produced dose-related elevations (p &lt; 0.01) of the cavernous tension, whereas PL and thiol-cleaved PRL in comparable doses were without effect (p &gt; 0.05).	Sulfhydryl Compounds	113-118	prolactin	Canis lupus familiaris	127-130
8707265-0	1996	Hepatotoxicity of the herbal medicine germander: metabolic activation of its furano diterpenoids by cytochrome P450 3A Depletes cytoskeleton-associated protein thiols and forms plasma membrane blebs in rat hepatocytes.	Sulfhydryl Compounds	160-166	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	100-118
8694843-13	1996	Consistent with the assumption that a thiol residue is involved in this inactivation, a significant part of the activity could be restored by treatment of the inactivated GST with GSH or dithiotreitol.	Sulfhydryl Compounds	38-43	glutathione S-transferase kappa 1	Homo sapiens	171-174
8853457-2	1996	Monoclonal antibody to the alpha subunit of human chorionic gonadotropin (hCG) was modified by incorporation of cystamine into the Fc-carbohydrate, followed by reduction with dithiothreitol resulting in the generation of 4.5 free thiols per IgG.	Sulfhydryl Compounds	230-236	chorionic gonadotropin subunit beta 5	Homo sapiens	27-78
8707265-10	1996	We conclude that the furano diterpenoids of germander are activated by CYP3A into electrophilic metabolites that deplete glutathione and cytoskeleton-associated protein thiols and form plasma membrane blebs.	Sulfhydryl Compounds	169-175	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	71-76
8751605-11	1996	Normal peripheral blood neutrophil chemotactic responses and CD11b expression suggest that thiol depletion might mediate this effect through inhibition of endothelial cell adhesion molecule activity.	Sulfhydryl Compounds	91-96	integrin subunit alpha M	Rattus norvegicus	61-66
8703941-6	1996	Of the five Cys residues in the human gelsolin sequence, all were present in the free thiol form in human cytoplasmic gelsolin, while only three of them were free thiols in the human plasma form.	Sulfhydryl Compounds	86-91	gelsolin	Homo sapiens	38-46
8703941-6	1996	Of the five Cys residues in the human gelsolin sequence, all were present in the free thiol form in human cytoplasmic gelsolin, while only three of them were free thiols in the human plasma form.	Sulfhydryl Compounds	86-91	gelsolin	Homo sapiens	118-126
8663382-4	1996	However, refolding of denatured/reduced lysozyme into buffer that lacks thiol/disulfide reagents leads to aggregation.	Sulfhydryl Compounds	72-77	lysozyme	Homo sapiens	40-48
8805567-7	1996	Cys1 is the catalytic nucleophile in GLMS, and the nucleophilic character of its thiol group appears to be increased through general base activation by its own alpha-amino group.	Sulfhydryl Compounds	81-86	cystin 1	Homo sapiens	0-4
8692688-3	1996	Here, it is shown that isoleucyl-tRNA synthetase (IleRS), which occasionally misactivates homocysteine in vitro and in vivo, catalyzes reactions of activated isoleucine with organic thiols (analogues of the side chain of homocysteine).	Sulfhydryl Compounds	182-188	isoleucyl-tRNA synthetase 1	Homo sapiens	23-48
8845017-0	1996	Alternative binding of p56lck and phosphatidylinositol 3-kinase in T cells by sulfhydryl oxidation: implication of aberrant signaling due to oxidative stress in T lymphocytes.	Sulfhydryl Compounds	78-88	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	23-29
8845017-4	1996	In this study using cultured peripheral blood T lymphocytes (PBL blasts), we show that upon the sulfhydryl oxidation-induced tyrosine phosphorylation of p56lck, the kinase associates with phosphatidylinositol (PI) 3-kinase p85 subunit via the binding of the C-terminal SH2 domain of p85 to the tyrosine-phosphorylated p56lck.	Sulfhydryl Compounds	96-106	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	153-159
8845017-4	1996	In this study using cultured peripheral blood T lymphocytes (PBL blasts), we show that upon the sulfhydryl oxidation-induced tyrosine phosphorylation of p56lck, the kinase associates with phosphatidylinositol (PI) 3-kinase p85 subunit via the binding of the C-terminal SH2 domain of p85 to the tyrosine-phosphorylated p56lck.	Sulfhydryl Compounds	96-106	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	223-226
8692688-3	1996	Here, it is shown that isoleucyl-tRNA synthetase (IleRS), which occasionally misactivates homocysteine in vitro and in vivo, catalyzes reactions of activated isoleucine with organic thiols (analogues of the side chain of homocysteine).	Sulfhydryl Compounds	182-188	isoleucyl-tRNA synthetase 1	Homo sapiens	50-55
8845017-4	1996	In this study using cultured peripheral blood T lymphocytes (PBL blasts), we show that upon the sulfhydryl oxidation-induced tyrosine phosphorylation of p56lck, the kinase associates with phosphatidylinositol (PI) 3-kinase p85 subunit via the binding of the C-terminal SH2 domain of p85 to the tyrosine-phosphorylated p56lck.	Sulfhydryl Compounds	96-106	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	283-286
8845017-4	1996	In this study using cultured peripheral blood T lymphocytes (PBL blasts), we show that upon the sulfhydryl oxidation-induced tyrosine phosphorylation of p56lck, the kinase associates with phosphatidylinositol (PI) 3-kinase p85 subunit via the binding of the C-terminal SH2 domain of p85 to the tyrosine-phosphorylated p56lck.	Sulfhydryl Compounds	96-106	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	318-324
8692688-4	1996	That these enzymatic reactions occur between Ile-tRNAIle or Ile-AMP (bound in the synthetic sub-site) and a thiol (an analogue of the side chain of homocysteine, bound in the editing sub-site), indicates that the two sub-sites are physically close on the surface of IleRS, forming a single synthetic/editing active site of the enzyme.	Sulfhydryl Compounds	108-113	isoleucyl-tRNA synthetase 1	Homo sapiens	266-271
21153281-17	1996	When C189 and C197 are present as free thiols in intragranular PRL, these may also contribute to binding.	Sulfhydryl Compounds	39-45	prolactin	Rattus norvegicus	63-66
8663080-2	1996	The thiol-specific antioxidant protein (TSA) protects glutamine synthetase from inactivation by a metal-catalyzed oxidation (MCO) system comprised of dithiothreitol (DTT)/Fe3+/O2 but not by the ascorbate/Fe3+/O2 MCO system.	Sulfhydryl Compounds	4-9	glutamate-ammonia ligase	Homo sapiens	54-74
8679580-4	1996	Thioester formation occurs when a thiol and activated methionine, in the form of Met-tRNA, are incubated with MetRS.	Sulfhydryl Compounds	34-39	methionyl-tRNA synthetase 1	Homo sapiens	110-115
8679586-9	1996	(1989), we found that CBP2 had little thiol:protein disulfide oxidoreductase activity.	Sulfhydryl Compounds	38-43	serpin family H member 1	Homo sapiens	22-26
8672469-3	1996	Similarities and differences in their structures help to explain why thioredoxins are reductants, whereas PDI is an oxidant of protein thiol groups.	Sulfhydryl Compounds	135-140	prolyl 4-hydroxylase subunit beta	Homo sapiens	106-109
8662787-7	1996	Furthermore, we show that the induction of AP-1 and NF-kappaB activities and GST Ya gene expression by BHA and TBHQ is due to a pro-oxidant activity, since this induction was inhibited by thiol compounds N-acetyl cysteine and GSH.	Sulfhydryl Compounds	188-193	glutathione S-transferase kappa 1	Homo sapiens	77-80
8660376-4	1996	However, incubation of CETP with hydrophobic thiol-modifying reagents such as p-chloromercuriphenylsulfonic acid (IC50 = 0.02 microM), 4,4"-dithiodipyridine (IC50 = 0.5 microM), or 4,4"-dithiobis (phenyl azide) (IC50 = 0.5 microM) resulted in complete, time-dependent inactivation of both the cholesteryl ester and triglyceride transfer activities.	Sulfhydryl Compounds	45-50	cholesteryl ester transfer protein	Homo sapiens	23-27
8744334-2	1996	Experiments demonstrated that a thiol-containing reducing agent, mercaptoethylamine (MEA or cysteamine), was the most effective, among other commonly known radical quenchers or singlet oxygen scavengers, in suppressing photobleaching of fluorescein while not reducing the fluorescence quantum yield.	Sulfhydryl Compounds	32-37	male-enhanced antigen 1	Homo sapiens	85-88
8679570-1	1996	Binding of mitochondrial cyclophilin (CyP) to the inner mitochondrial membrane is induced by treatment of mitochondria with thiol reagents or oxidative stress and correlates with a sensitization to [Ca2+] of the cyclosporin A-sensitive mitochondrial permeability transition pore (MTP) [Connern, C. P., &amp; Halestrap, A. P. (1994) Biochem.	Sulfhydryl Compounds	124-129	peptidylprolyl isomerase G	Homo sapiens	25-36
8679570-1	1996	Binding of mitochondrial cyclophilin (CyP) to the inner mitochondrial membrane is induced by treatment of mitochondria with thiol reagents or oxidative stress and correlates with a sensitization to [Ca2+] of the cyclosporin A-sensitive mitochondrial permeability transition pore (MTP) [Connern, C. P., &amp; Halestrap, A. P. (1994) Biochem.	Sulfhydryl Compounds	124-129	peptidylprolyl isomerase G	Homo sapiens	38-41
8674534-1	1996	We have recently described a method for identifying contact sites between actin and thymosin beta4 (Tbeta4) by following spectrophotometrically the extent and kinetics of distinct, thiol-specific crosslinking reactions between appropriate derivatives of the two proteins [Reichert et a].	Sulfhydryl Compounds	181-186	thymosin beta 4 X-linked	Homo sapiens	84-98
8674534-1	1996	We have recently described a method for identifying contact sites between actin and thymosin beta4 (Tbeta4) by following spectrophotometrically the extent and kinetics of distinct, thiol-specific crosslinking reactions between appropriate derivatives of the two proteins [Reichert et a].	Sulfhydryl Compounds	181-186	thymosin beta 4 X-linked	Homo sapiens	100-106
8651684-0	1996	Effect of superoxide dismutase mimics on radical adduct formation during the reaction between peroxynitrite and thiols--an ESR-spin trapping study.	Sulfhydryl Compounds	112-118	superoxide dismutase 1	Homo sapiens	10-30
8603515-5	1996	In addition, decreased levels of cellular thiols observed in resting CD4+ lymphocytes from these patients suggested a disturbed redox status.	Sulfhydryl Compounds	42-48	CD4 molecule	Homo sapiens	69-72
8670254-1	1996	A 65-kDa molecular mass of thiol-specific antioxidant protein was purified from human plasma and identified as human serum albumin (HSA) by the analysis of amino-terminal amino acid sequence.	Sulfhydryl Compounds	27-32	albumin	Homo sapiens	117-130
8670254-6	1996	Both the preventive activity against the glutamine synthetase inactivation and the peroxidase activity were completely abolished by the reactions of HSA with N-ethylmaleimide and iodoacetate, chemical modification agents for sulfhydryl of protein, only in the presence of thiol-reducing equivalent such as DTT.	Sulfhydryl Compounds	272-277	glutamate-ammonia ligase	Homo sapiens	41-61
8736558-1	1996	BACKGROUND: Human thioredoxin (hTRX) is a 12 kDa cellular redox protein that has been shown to play an important role in the activation of a number of transcriptional and translational regulators via a thiol-redox mechanism.	Sulfhydryl Compounds	202-207	thioredoxin	Homo sapiens	18-29
8736558-1	1996	BACKGROUND: Human thioredoxin (hTRX) is a 12 kDa cellular redox protein that has been shown to play an important role in the activation of a number of transcriptional and translational regulators via a thiol-redox mechanism.	Sulfhydryl Compounds	202-207	thioredoxin	Homo sapiens	31-35
8645136-4	1996	This fluorescence quenching was used as the basis for monitoring the disulphide bond-forming activity of the enzymes protein disulphide-isomerase (PDI) and DsbA (a periplasmic protein thiol:disulphide oxidoreductase) in the pH range 4.0-7.5, where the rates of spontaneous or chemical oxidation are low.	Sulfhydryl Compounds	184-189	prolyl 4-hydroxylase subunit beta	Bos taurus	117-145
8645136-4	1996	This fluorescence quenching was used as the basis for monitoring the disulphide bond-forming activity of the enzymes protein disulphide-isomerase (PDI) and DsbA (a periplasmic protein thiol:disulphide oxidoreductase) in the pH range 4.0-7.5, where the rates of spontaneous or chemical oxidation are low.	Sulfhydryl Compounds	184-189	prolyl 4-hydroxylase subunit beta	Bos taurus	147-150
8626483-2	1996	We surveyed conditions for renaturation of purified rMMP-1 in 6 M guandine hydrochloride (GdnHCl) and found that optimal folding occurred when the denatured protein was diluted at 4 degrees C in approximately 2 M guanidine HCl, 20% glycerol, 2.5 mM reduced and oxidized glutathione, and 5 mM CaCl2, followed by buffer exchange to remove denaturant and thiols.	Sulfhydryl Compounds	352-358	matrix metallopeptidase 1	Rattus norvegicus	52-58
8762135-12	1996	In contrast, we conclude that Tyr 8 facilitates the ionization of the thiol group of glutathione bound to glutathione S-transferase, but is not required for enzyme activity.	Sulfhydryl Compounds	70-75	hematopoietic prostaglandin D synthase	Rattus norvegicus	106-131
8753066-10	1996	Using three orthogonal thiol protecting groups, Trt, Acm, and But, three disulfide bonds of human insulin were efficiently constructed by the successive reactions using thiolysis, iodine oxidation, and the sily1 chloride method.	Sulfhydryl Compounds	23-28	insulin	Homo sapiens	98-105
8660549-1	1996	The transfer of nitroso groups from S-nitroso-L-cysteine (1) and six other simple S-nitrosothiols to Cys 34 of bovine serum albumin (2) has been followed using Ellman"s reagent, 5,5"-dithio-bis (2-nitrobenzoate) (3), to detect the resulting thiols.	Sulfhydryl Compounds	91-97	albumin	Homo sapiens	118-131
8796302-3	1996	These results suggest that BIE is a metalloendopeptidase containing a thiol group important for its activity.	Sulfhydryl Compounds	70-75	thimet oligopeptidase 1	Rattus norvegicus	36-56
8622594-6	1996	We conclude that the long-acting, non-sulfhydryl-containing ACE inhibitor, trandolapril, alone and in combination with the Ca2+-channel blocker, verapamil, can significantly improve insulin-stimulated glucose transport activity in skeletal muscle of the insulin-resistant obese Zucker rat, and that this improvement is associated with favorable adaptive responses in GLUT-4 protein levels, glycogen storage, and activities of relevant intracellular enzymes of glucose catabolism.	Sulfhydryl Compounds	38-48	angiotensin I converting enzyme	Rattus norvegicus	60-63
8621522-0	1996	Use of the thiol-specific derivatizing agent N-iodoacetyl-3-[125I]iodotyrosine to demonstrate conformational differences between the unbound and hsp90-bound glucocorticoid receptor hormone binding domain.	Sulfhydryl Compounds	11-16	heat shock protein 90 alpha family class A member 1	Homo sapiens	145-150
8621522-0	1996	Use of the thiol-specific derivatizing agent N-iodoacetyl-3-[125I]iodotyrosine to demonstrate conformational differences between the unbound and hsp90-bound glucocorticoid receptor hormone binding domain.	Sulfhydryl Compounds	11-16	nuclear receptor subfamily 3 group C member 1	Homo sapiens	157-180
8621522-5	1996	Here, we assess the effects of hsp90 binding on the accessibility of cysteine residues in both the HBD and DBD to derivatization by a thiol-specific reagent.	Sulfhydryl Compounds	134-139	heat shock protein 90 alpha family class A member 1	Homo sapiens	31-36
8621522-7	1996	The 125I-labeled IAT derivative N-iodoacetyl-3-[125I]iodotyrosine ([125I]IAIT) covalently labels the immunopurified, hsp90-bound receptor in a thiol-specific manner.	Sulfhydryl Compounds	143-148	heat shock protein 90 alpha family class A member 1	Homo sapiens	117-122
8621522-9	1996	The increase in thiol labeling is related to the presence of hsp90 because it is blocked by molybdate, which prevents hsp90 dissociation.	Sulfhydryl Compounds	16-21	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-66
8621522-9	1996	The increase in thiol labeling is related to the presence of hsp90 because it is blocked by molybdate, which prevents hsp90 dissociation.	Sulfhydryl Compounds	16-21	heat shock protein 90 alpha family class A member 1	Homo sapiens	118-123
8621522-12	1996	These data are consistent with the proposal that dissociation of hsp90 from the GR produces a conformational change in the HBD such that some of the thiols that are exposed in the GR*hsp90 complex become buried and are no longer accessible to the [125I]IAIT probe.	Sulfhydryl Compounds	149-155	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-70
8621522-12	1996	These data are consistent with the proposal that dissociation of hsp90 from the GR produces a conformational change in the HBD such that some of the thiols that are exposed in the GR*hsp90 complex become buried and are no longer accessible to the [125I]IAIT probe.	Sulfhydryl Compounds	149-155	nuclear receptor subfamily 3 group C member 1	Homo sapiens	80-82
8621522-12	1996	These data are consistent with the proposal that dissociation of hsp90 from the GR produces a conformational change in the HBD such that some of the thiols that are exposed in the GR*hsp90 complex become buried and are no longer accessible to the [125I]IAIT probe.	Sulfhydryl Compounds	149-155	nuclear receptor subfamily 3 group C member 1	Homo sapiens	180-182
8621522-12	1996	These data are consistent with the proposal that dissociation of hsp90 from the GR produces a conformational change in the HBD such that some of the thiols that are exposed in the GR*hsp90 complex become buried and are no longer accessible to the [125I]IAIT probe.	Sulfhydryl Compounds	149-155	heat shock protein 90 alpha family class A member 1	Homo sapiens	183-188
8621522-13	1996	In contrast, binding of the GR to hsp90 restricts access of cysteines in the DBD to this small thiol-derivatizing agent, a restriction that is relieved as a result of unmasking or conformational change accompanying hsp90 dissociation.	Sulfhydryl Compounds	95-100	nuclear receptor subfamily 3 group C member 1	Homo sapiens	28-30
8621522-13	1996	In contrast, binding of the GR to hsp90 restricts access of cysteines in the DBD to this small thiol-derivatizing agent, a restriction that is relieved as a result of unmasking or conformational change accompanying hsp90 dissociation.	Sulfhydryl Compounds	95-100	heat shock protein 90 alpha family class A member 1	Homo sapiens	34-39
8621522-13	1996	In contrast, binding of the GR to hsp90 restricts access of cysteines in the DBD to this small thiol-derivatizing agent, a restriction that is relieved as a result of unmasking or conformational change accompanying hsp90 dissociation.	Sulfhydryl Compounds	95-100	heat shock protein 90 alpha family class A member 1	Homo sapiens	215-220
8670138-1	1996	It has been reported that the activation of dihydrofolate reductase (DHFR) from L1210 mouse leukaemia cells by KCl or thiol modifiers is accompanied by increased digestibility by proteinases [Duffy, Beckman, Peterson, Vitols and Huennekens (1987) J. Biol.	Sulfhydryl Compounds	118-123	dihydrofolate reductase	Mus musculus	44-67
8670138-1	1996	It has been reported that the activation of dihydrofolate reductase (DHFR) from L1210 mouse leukaemia cells by KCl or thiol modifiers is accompanied by increased digestibility by proteinases [Duffy, Beckman, Peterson, Vitols and Huennekens (1987) J. Biol.	Sulfhydryl Compounds	118-123	dihydrofolate reductase	Mus musculus	69-73
8604085-5	1996	Characterization of PGF as a neutral cysteine proteinase was based on substrate and inhibitor specificities and dependence on pH and thiol-containing reagents.	Sulfhydryl Compounds	133-138	placental growth factor	Homo sapiens	20-23
11536750-5	1996	Whether thiols or CS2 were formed as the main products depended also on the FeS/HCl-ratio: All conditions which create a H2 deficiency were found to initiate a proportional increase in the amount of CS2.	Sulfhydryl Compounds	8-14	chorionic somatomammotropin hormone 2	Homo sapiens	199-202
8636095-5	1996	(i) A first site is in apparent oxidation-reduction equilibrium with the pyridine nucleotide (PN) pool (NADH/NAD + NADPH/NADP); PN oxidation is matched by increased MTP open probability under conditions where the glutathione pool is kept in the fully reduced state; this site can be blocked by N-ethylmaleimide but not by monobromobimane, a thiol-selective reagent.	Sulfhydryl Compounds	341-346	microsomal triglyceride transfer protein	Rattus norvegicus	165-168
8619991-10	1996	These results are compatible with the hydroxyl of Ser-228 being the catalytic nucleophile of cPLA2 and that cysteine can replace serine as the nucleophile, resulting ina thiol-cPLA2 with significantly reduced catalytic power.	Sulfhydryl Compounds	170-175	phospholipase A2 group IVA	Homo sapiens	176-181
8680862-9	1996	Another thiol-dependent enzyme glyceraldehyde-3-phosphate dehydrogenase was also markedly inhibited by EA in a time-dependent fashion.	Sulfhydryl Compounds	8-13	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	31-71
8645293-2	1996	We examined the effect of delta 12-prostaglandin (PG) J2, a thiol-reactive stress PG, on the expression of the PDI gene.	Sulfhydryl Compounds	60-65	prolyl 4-hydroxylase subunit beta	Homo sapiens	111-114
8605149-0	1996	Site-directed mutagenesis of Cys324 and Cys331 in human cytosolic phospholipase A2: locus of action of thiol modification reagents leading to inactiviation of cPLA2.	Sulfhydryl Compounds	103-108	phospholipase A2 group IVA	Homo sapiens	56-82
8605149-0	1996	Site-directed mutagenesis of Cys324 and Cys331 in human cytosolic phospholipase A2: locus of action of thiol modification reagents leading to inactiviation of cPLA2.	Sulfhydryl Compounds	103-108	phospholipase A2 group IVA	Homo sapiens	159-164
8605149-1	1996	Human cytosolic phospholipase A2 contains two cysteines, cyS324 and cyS331, chemical modification of which using thiol modifying reagents abolishes the activity of the enzyme [Li et al.	Sulfhydryl Compounds	113-118	phospholipase A2 group IVA	Homo sapiens	6-32
8636121-1	1996	The M344 tumor-associated antigen, expressed in 70% of superficial bladder tumors, is a sialylated carbohydrate present on a high molecular mass thiol-reducible secreted mucin, which we named MAUB for mucin antigen of the urinary bladder.	Sulfhydryl Compounds	145-150	LOC100508689	Homo sapiens	170-175
8636121-1	1996	The M344 tumor-associated antigen, expressed in 70% of superficial bladder tumors, is a sialylated carbohydrate present on a high molecular mass thiol-reducible secreted mucin, which we named MAUB for mucin antigen of the urinary bladder.	Sulfhydryl Compounds	145-150	LOC100508689	Homo sapiens	201-206
8907254-3	1996	Our experiments now suggest that modulation of these sulfhydryls may involve the action of thiol-modifying oxido-reductases such as protein disulfide isomerase (PDI).	Sulfhydryl Compounds	91-96	prolyl 4-hydroxylase subunit beta	Homo sapiens	132-159
8670069-11	1996	Together, these results demonstrate that both free-radical generation and thiol modification can transcriptionally activate GADD153, and that AP-1 is critical to oxidative regulation of this gene.	Sulfhydryl Compounds	74-79	DNA damage inducible transcript 3	Homo sapiens	124-131
8670069-3	1996	Both commonalities and distinctions in the induction of GADD153 by H2O2 and the thiol-reactive compound arsenite were demonstrated.	Sulfhydryl Compounds	80-85	DNA damage inducible transcript 3	Homo sapiens	56-63
8907254-3	1996	Our experiments now suggest that modulation of these sulfhydryls may involve the action of thiol-modifying oxido-reductases such as protein disulfide isomerase (PDI).	Sulfhydryl Compounds	91-96	prolyl 4-hydroxylase subunit beta	Homo sapiens	161-164
8611025-6	1996	The determination of the rate constants of reaction of superoxide radical with thiols by spectrophotometrical cytochrome C assay could result in an underestimation of the values due to the reduction of cytochrome C by thiols.	Sulfhydryl Compounds	79-85	cytochrome c, somatic	Homo sapiens	110-122
8603589-4	1996	Data suggest intermolecular disulfide bridges and/or intermolecular ionic interactions, as thiols, urea, and chelators increase monomerization of the majority of granule PRL.	Sulfhydryl Compounds	91-97	prolactin	Rattus norvegicus	170-173
8603589-9	1996	As hormone free thiols were potentially formed during PRL oligomerization and storage, these were possible sites for hormone-divalent cation interactions.	Sulfhydryl Compounds	16-22	prolactin	Rattus norvegicus	54-57
8603589-12	1996	It is proposed that binding of zinc stabilizes the intermolecularly bonded storage form of PRL, in part by protection of hormone free thiols.	Sulfhydryl Compounds	134-140	prolactin	Rattus norvegicus	91-94
8617749-15	1996	However, cellular thiol-disulfide redox status and formation of disulfide linked aggregates of cellular proteins are linked to HSF1 activation and hsp70 transcriptional activation.	Sulfhydryl Compounds	18-23	heat shock transcription factor 1	Homo sapiens	127-131
8617749-15	1996	However, cellular thiol-disulfide redox status and formation of disulfide linked aggregates of cellular proteins are linked to HSF1 activation and hsp70 transcriptional activation.	Sulfhydryl Compounds	18-23	heat shock protein family A (Hsp70) member 4	Homo sapiens	147-152
8611025-6	1996	The determination of the rate constants of reaction of superoxide radical with thiols by spectrophotometrical cytochrome C assay could result in an underestimation of the values due to the reduction of cytochrome C by thiols.	Sulfhydryl Compounds	79-85	cytochrome c, somatic	Homo sapiens	202-214
8631927-0	1996	The molecular pathway for the regulation of phosphoribulokinase by thioredoxin f. Phosphoribulokinase (PRK) is one of several plant enzymes that is regulated by thiol-disulfide exchange as mediated by thioredoxin, which contains spatially vicinal, redox-active cysteinyl residues.	Sulfhydryl Compounds	161-166	thioredoxin	Homo sapiens	67-78
8631927-0	1996	The molecular pathway for the regulation of phosphoribulokinase by thioredoxin f. Phosphoribulokinase (PRK) is one of several plant enzymes that is regulated by thiol-disulfide exchange as mediated by thioredoxin, which contains spatially vicinal, redox-active cysteinyl residues.	Sulfhydryl Compounds	161-166	thioredoxin	Homo sapiens	201-212
8611025-6	1996	The determination of the rate constants of reaction of superoxide radical with thiols by spectrophotometrical cytochrome C assay could result in an underestimation of the values due to the reduction of cytochrome C by thiols.	Sulfhydryl Compounds	218-224	cytochrome c, somatic	Homo sapiens	110-122
8611025-6	1996	The determination of the rate constants of reaction of superoxide radical with thiols by spectrophotometrical cytochrome C assay could result in an underestimation of the values due to the reduction of cytochrome C by thiols.	Sulfhydryl Compounds	218-224	cytochrome c, somatic	Homo sapiens	202-214
8576116-0	1996	Identification of contact sites in the actin-thymosin beta 4 complex by distance-dependent thiol cross-linking.	Sulfhydryl Compounds	91-96	thymosin beta 4 X-linked	Homo sapiens	45-60
8634298-0	1996	Mechanism of ubiquitin conjugating enzyme E2-230K: catalysis involving a thiol relay?	Sulfhydryl Compounds	73-78	ubiquitin conjugating enzyme E2 O	Homo sapiens	42-49
9026538-2	1996	The mechanism of VLDL assembly was explored by perturbing apoB folding in HepG2 cells with the thiol reducing agent dithiothreitol (DTT).	Sulfhydryl Compounds	95-100	apolipoprotein B	Homo sapiens	58-62
20650183-2	1996	It has been shown that one-electron reduction of the VP-16 phenoxyl radical by ascorbate and thiols prevents/delays its oxidative metabolism by tyrosinase both in model systems and in cell homogenates.	Sulfhydryl Compounds	93-99	host cell factor C1	Homo sapiens	53-58
20650183-3	1996	To elucidate the role of endogenous thiols in the reduction of VP-16 phenoxyl radicals, K562 human leukaemia cells grown in Dulbecco"s modified Eagle"s medium which does not contain vitamin C (ascorbate) were used, thus excluding the ascorbate-dependent reduction of VP-16 phenoxyl radicals.	Sulfhydryl Compounds	36-42	host cell factor C1	Homo sapiens	63-68
20650183-4	1996	VP-16 phenoxyl radicals were reduced by endogenous reductants in K562 cell homogenates, intracellular thiols mainly being responsible.	Sulfhydryl Compounds	102-108	host cell factor C1	Homo sapiens	0-5
20650183-5	1996	Depletion of endogenous thiols by mersalyl acid resulted in almost complete inhibition of the ability of cell homogenates to reduce VP-16 phenoxyl radicals.	Sulfhydryl Compounds	24-30	host cell factor C1	Homo sapiens	132-137
20650183-7	1996	Depletion of thiols in K562 cells or cell homogenates proportionally decreased the ability of homogenates to reduce VP-16 phenoxyl radicals.	Sulfhydryl Compounds	13-19	host cell factor C1	Homo sapiens	116-121
20650183-10	1996	Elevation of endogenous thiols by cadmium chloride increased the ability of homogenates to reduce VP-16 phenoxyl radicals but did not reveal any significant difference in the ability of the two types of cells to interact with VP-16 radicals.	Sulfhydryl Compounds	24-30	host cell factor C1	Homo sapiens	98-103
8576116-1	1996	Binding sites of actin and thymosin beta 4 were investigated using a set of bifunctional thiol-specific reagents, which allowed the insertion of cross-linkers of defined lengths between cysteine residues of the complexed proteins.	Sulfhydryl Compounds	89-94	thymosin beta 4 X-linked	Homo sapiens	27-42
8549822-3	1996	Permeability transition is prevented either by EGTA, catalase or dithiothreitol, suggesting the involvement of Ca2+, H2O2 and oxidation of membrane protein thiols in this mechanism.	Sulfhydryl Compounds	156-162	catalase	Homo sapiens	53-61
8543831-2	1996	Thioredoxin is one of the major redox-regulatory molecules which because of its dithiol/disulfide exchange activity determines the oxidation state of protein thiols.	Sulfhydryl Compounds	158-164	thioredoxin	Homo sapiens	0-11
8557633-4	1996	N alpha-[(acetylthio)acetyl]-(D-Phe)-Phe-Arg-CH2Cl; the thiol group generated subsequently on the incorporated inhibitor with NH2OH was quantitatively labeled with the fluorescence probe, 2-((4"-iodoacetamido)anilino)naphthalene-6-sulfonic acid; and the labeled Pg was separated from SK.	Sulfhydryl Compounds	56-61	plasminogen	Homo sapiens	262-264
9328633-4	1996	The redox reaction between Cd2+ and receptor thiols may result in binding of the metal into stable (di)thiol-cadmium complexes rather than in the formation of disulfide and liberation of the reduced metal.	Sulfhydryl Compounds	45-51	CD2 molecule	Homo sapiens	27-30
8529793-6	1996	Both acute and chronic administration of a sulfhydryl-containing ACE inhibitor (captopril) or a non-sulfhydryl-containing ACE inhibitor (tran-dolapril) significantly enhanced in vitro insulin-mediated muscle glucose transport activity.	Sulfhydryl Compounds	43-53	angiotensin I converting enzyme	Rattus norvegicus	65-68
8874796-5	1996	The rate constant of the rCK-reactive thiol reacting with DTNB is close to that of the slow phase of the reactive thiols of the native enzyme.	Sulfhydryl Compounds	38-43	dystrobrevin beta	Homo sapiens	58-62
8874796-5	1996	The rate constant of the rCK-reactive thiol reacting with DTNB is close to that of the slow phase of the reactive thiols of the native enzyme.	Sulfhydryl Compounds	114-120	dystrobrevin beta	Homo sapiens	58-62
8616907-9	1996	From these findings, we speculate that the intracellular oxidative environment could affect the redox state of protein thiols in HMG1 and HMG2 and in addition, regulate the ability of these proteins to recognize cis-Pt-DNA adduct formation in tumor cells.	Sulfhydryl Compounds	119-125	high mobility group box 1 pseudogene 5	Homo sapiens	129-133
8616907-9	1996	From these findings, we speculate that the intracellular oxidative environment could affect the redox state of protein thiols in HMG1 and HMG2 and in addition, regulate the ability of these proteins to recognize cis-Pt-DNA adduct formation in tumor cells.	Sulfhydryl Compounds	119-125	high mobility group box 2	Homo sapiens	138-142
8742061-1	1996	Human ADF (adult T cell leukaemia-derived factor), an isoform of thioredoxin, promotes proliferation of certain human lymphoid cell lines and is involved in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	162-167	thioredoxin	Homo sapiens	6-9
8742061-1	1996	Human ADF (adult T cell leukaemia-derived factor), an isoform of thioredoxin, promotes proliferation of certain human lymphoid cell lines and is involved in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	162-167	thioredoxin	Homo sapiens	65-76
8565766-7	1996	It thus follows that sulfhydryl compounds accelerate the secretion of deep mucin and accumulate surface mucin.	Sulfhydryl Compounds	21-41	solute carrier family 13 member 2	Rattus norvegicus	75-80
8565766-7	1996	It thus follows that sulfhydryl compounds accelerate the secretion of deep mucin and accumulate surface mucin.	Sulfhydryl Compounds	21-41	solute carrier family 13 member 2	Rattus norvegicus	104-109
8529793-6	1996	Both acute and chronic administration of a sulfhydryl-containing ACE inhibitor (captopril) or a non-sulfhydryl-containing ACE inhibitor (tran-dolapril) significantly enhanced in vitro insulin-mediated muscle glucose transport activity.	Sulfhydryl Compounds	100-110	angiotensin I converting enzyme	Rattus norvegicus	122-125
8838593-5	1996	The minimum concentration of the thiol compound required for optimal activation of cathepsin B was found to be lowest (0.2 mM) for DTE.	Sulfhydryl Compounds	33-38	cathepsin B	Homo sapiens	83-94
8838593-6	1996	The BANA hydrolyzing activity of cathepsin B was substantially reduced by Cu2+ (20-200 microM) and Ca2+ (30-250 mM) as well as by thiol blocking reagents, e.g., iodoacetate, 5,5"-dithiobis(2-nitro-benzoic acid) (DTNB), and p-hydroxymercuribenzoate (pHMB).	Sulfhydryl Compounds	130-135	cathepsin B	Homo sapiens	33-44
8838593-9	1996	Modification of one free thiol group of cathepsin B resulted in complete loss of BANA hydrolyzing activity.	Sulfhydryl Compounds	25-30	cathepsin B	Homo sapiens	40-51
8992314-5	1996	The deamidation of AF1 was inhibited by phenylmethylsulfonyl fluoride, p-chloromercuricphenylsulfonate and mercuric chloride, indicating that the deamidase enzyme is a serine protease with a requirement for a free thiol group for activity.	Sulfhydryl Compounds	214-219	interferon gamma receptor 2	Homo sapiens	19-22
8761339-3	1996	In contrast, exogenous sulfhydryl reducing reagents are necessary to insure maximum binding of mineralocorticoid receptor and DNA/steroid-receptor interaction.	Sulfhydryl Compounds	23-33	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	95-121
8825449-3	1996	The proteinase activity is insensitive to thiol-blocking compounds and to 5 mM 1,10-phenanthroline, a relatively specific chelator of zinc.	Sulfhydryl Compounds	42-47	endogenous retrovirus group K member 25	Homo sapiens	4-14
8597660-6	1996	This glutathione-dependent regulation indicates that maize IRL may play a crucial role in the establishment of a thiol-independent response to oxidative stress under glutathione shortage conditions.	Sulfhydryl Compounds	113-118	isoflavone reductase homolog IRL	Zea mays	59-62
8533007-2	1996	The latter are exemplified by protein thiol modification followed by subsequent NAD(+)-dependent automodification of the glycolytic enzyme GAPDH, or by mechanisms inducing accumulation of the tumor suppressor gene p53 and causing apoptotic cell death.	Sulfhydryl Compounds	38-43	tumor protein p53	Homo sapiens	214-217
8750971-3	1995	Superoxide dismutase, a NO scavenger, and sulfhydryl (SH) compounds, reduced-form glutathione (rGSH) and dithiothreitol (DTT), prevented the inhibitory action of SNAP, SIN-1 and NOR 3 but not of SNP, when applied simultaneously with NO generating compounds, and this enzyme inhibition could be reactivated by the incubation with these SH compounds but not with SOD.	Sulfhydryl Compounds	42-52	MAPK associated protein 1	Homo sapiens	168-173
9601550-4	1996	Due to a specific labeling of the free thiol groups of the Fab" fragments, the antigen binding capacity was not affected by the attachment of the markers and the resulting immunoprobes exhibited an elongated shape with the antigen combining site and the label located at opposite ends.	Sulfhydryl Compounds	39-44	FA complementation group B	Homo sapiens	59-62
8554508-1	1995	The acidic peroxidoxin [also named thiol-specific antioxidant protein (TSA) or protector protein (PRP)], which plays a role in the response against oxidative stress, is one of the major proteins of red blood cells.	Sulfhydryl Compounds	35-40	peroxiredoxin 2	Homo sapiens	79-96
8554508-1	1995	The acidic peroxidoxin [also named thiol-specific antioxidant protein (TSA) or protector protein (PRP)], which plays a role in the response against oxidative stress, is one of the major proteins of red blood cells.	Sulfhydryl Compounds	35-40	peroxiredoxin 2	Homo sapiens	98-101
7500023-0	1995	Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis.	Sulfhydryl Compounds	0-6	interleukin 4	Homo sapiens	22-40
8541353-6	1995	Thiol compounds, glutathione (GSH) and 2-mercaptoethanol, abrogated the inhibition of the growth of U937 cells by herbimycin A, but not by 19-allylaminoherbimycin A, like GM-CSF.	Sulfhydryl Compounds	0-5	colony stimulating factor 2	Homo sapiens	171-177
8927035-6	1995	For example, treatment with two equivalents of glutathione or other thiols the (dipicolinato)peroxovanadate(V) forms (dipicolinato)oxovanadate(V) and vanadate, which are both insulin-mimetic vanadium(V) compounds and can continue to act.	Sulfhydryl Compounds	68-74	insulin	Homo sapiens	175-182
8519646-3	1995	hA33 labelled with yttrium-90 using the macrocyclic chelator 12N4 (DOTA) was shown to localise very effectively to human colon tumour xenografts in nude mice, with tumour levels increasing as blood concentration fell up to 144 h. A Fab" variant of hA33 with a single hinge thiol group to facilitate chemical cross-linking has also been constructed and expressed with yields of 500 mg l-1.	Sulfhydryl Compounds	273-278	glycoprotein A33	Homo sapiens	0-4
7499370-5	1995	Because herbimycin A is thiol-reactive, we suspected that the target was the p50 subunit of NF-kappa B, which has a key thiol at cysteine 62.	Sulfhydryl Compounds	24-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-102
7499370-5	1995	Because herbimycin A is thiol-reactive, we suspected that the target was the p50 subunit of NF-kappa B, which has a key thiol at cysteine 62.	Sulfhydryl Compounds	120-125	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	77-102
7499372-0	1995	Thiol-disulfide exchange of ribonuclease inhibitor bound to ribonuclease A.	Sulfhydryl Compounds	0-5	ribonuclease/angiogenin inhibitor 1	Sus scrofa	28-50
7499372-8	1995	Under comparable reaction conditions, testis RI bound to RNase A did not exhibit this particular type of oxidation; instead, bound RI got intermediate oxidation degrees (up to 14 thiols oxidized per RI moiety) without dissociating from RNase.	Sulfhydryl Compounds	179-185	ribonuclease/angiogenin inhibitor 1	Sus scrofa	131-133
7499372-8	1995	Under comparable reaction conditions, testis RI bound to RNase A did not exhibit this particular type of oxidation; instead, bound RI got intermediate oxidation degrees (up to 14 thiols oxidized per RI moiety) without dissociating from RNase.	Sulfhydryl Compounds	179-185	ribonuclease/angiogenin inhibitor 1	Sus scrofa	131-133
7499372-10	1995	Only when DTNB treatments accounted for complex dissociation (&gt; 14 thiols oxidized per RI moiety) the released RI molecules exhibited the all-or-none oxidation behavior.	Sulfhydryl Compounds	70-76	ribonuclease/angiogenin inhibitor 1	Sus scrofa	114-116
8522579-0	1995	Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B.	Sulfhydryl Compounds	0-5	nuclear factor kappa B subunit 1	Homo sapiens	125-135
8522579-13	1995	Understanding the precise mechanism by which Bcl-2 and thiol agents inhibit SV-induced nuclear NF-kappa B activity in AT-3 cells may provide insights into the pluripotent antiapoptotic actions of these agents.	Sulfhydryl Compounds	55-60	nuclear factor kappa B subunit 1	Homo sapiens	95-105
7500023-0	1995	Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis.	Sulfhydryl Compounds	0-6	interleukin 4	Homo sapiens	56-60
7500023-12	1995	These results demonstrate that NAC, GSH, and other thiols may control the production of both the Th2-derived cytokine IL-4 and IL-4-induced Ig in vitro and in vivo.	Sulfhydryl Compounds	51-57	interleukin 4	Homo sapiens	118-122
7500023-12	1995	These results demonstrate that NAC, GSH, and other thiols may control the production of both the Th2-derived cytokine IL-4 and IL-4-induced Ig in vitro and in vivo.	Sulfhydryl Compounds	51-57	interleukin 4	Homo sapiens	127-131
7488219-3	1995	The purified protein showed the thiol-specific antioxidant activity and protected glutamine synthetase from inactivation by a mixed metal-thiol oxidation.	Sulfhydryl Compounds	32-37	glutamate-ammonia ligase	Rattus norvegicus	82-102
7488219-3	1995	The purified protein showed the thiol-specific antioxidant activity and protected glutamine synthetase from inactivation by a mixed metal-thiol oxidation.	Sulfhydryl Compounds	138-143	glutamate-ammonia ligase	Rattus norvegicus	82-102
7578041-1	1995	Detailed analyses of the pH variation of kinetic parameters for the forward aldehyde reduction and reverse alcohol oxidation reactions mediated by recombinant human aldose reductase, for inhibitor binding, and for kinetic isotope effects on aldehyde reduction have revealed that the pK value for the active site acid-base catalyst group Tyr48 is quite sensitive to the oxidation state of the bound nucleotide (NADPH or NADP+) and to the presence or absence of the Cys298 sulfhydryl moiety.	Sulfhydryl Compounds	471-481	aldo-keto reductase family 1 member B	Homo sapiens	165-181
7473753-1	1995	Relevance to unusual thiol pKa values in proteins of the thioredoxin family.	Sulfhydryl Compounds	21-26	thioredoxin	Homo sapiens	57-68
7491977-0	1995	Activation of NF-kappa B and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells.	Sulfhydryl Compounds	67-72	superoxide dismutase 2	Rattus norvegicus	42-47
7592822-3	1995	TlpA possesses an active-site disulfide bond common to all members of the thiol:disulfide oxidoreductase family.	Sulfhydryl Compounds	74-79	TlpA	Escherichia coli	0-4
7592822-13	1995	This suggests that TlpA"s primary role in vivo is keeping the thiols of certain proteins reduced and that TlpA"s active, reduced state may be maintained owing to its kinetically restricted oxidation by other periplasmic disulfide oxidoreductases such as DsbA.	Sulfhydryl Compounds	62-68	TlpA	Escherichia coli	19-23
7491977-8	1995	Because the MnSOD promoter also contains potential binding sites for other transcription factors, such as promoter-selective transcription factor-1 (SP-1), activator protein-1 (AP-1), AP-2, adenosine 3",5"-cyclic monophosphate-regulator element binding factor (CREB), and transcription factor IID complex (TFIID), the effect of thiols on their activation also were evaluated.	Sulfhydryl Compounds	328-334	superoxide dismutase 2	Rattus norvegicus	12-17
7491977-9	1995	In contrast to findings with NF-kappa B, there was only minor activation of AP-1 by thiols, and none of the other transcription factors were activated by thiols.	Sulfhydryl Compounds	84-90	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-80
7585502-5	1995	A direct correlation (P &lt; 0.01) between intracellular GSH levels and the LD99 dose of melphalan was observed, signifying that elevation of the thiol secondary to GCS expression is sufficient to confer the resistance phenotype.	Sulfhydryl Compounds	146-151	glutamate-cysteine ligase catalytic subunit	Homo sapiens	165-168
7491977-12	1995	This indicates that H2O2 produced as a result of autooxidation of thiols can activate AP-1 but not NF-kappa B.	Sulfhydryl Compounds	66-72	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-90
8747803-11	1995	Exogenous thiol compounds (e.g. NAC) augments the hypotensive effect of NTG by a tolerance nonspecific mechanism.	Sulfhydryl Compounds	10-15	synuclein alpha	Homo sapiens	32-35
8747803-20	1995	In the clinical setting administration of thiols results in a characteristic change in the vasodilator profile of nitrates and an attenuation of the nitrate-induced stimulation of the renin-angiotensin system.	Sulfhydryl Compounds	42-48	renin	Homo sapiens	184-189
7577954-0	1995	Oxidation of kinetically trapped thiols by protein disulfide isomerase.	Sulfhydryl Compounds	33-39	prolyl 4-hydroxylase subunit beta	Homo sapiens	43-70
8587043-9	1995	The data indicate the dimerization mechanism to involve an initial reduction of the Cys7-Cys161 disulfide bond and subsequent random reoxidation of the free thiols across two EPO molecules.	Sulfhydryl Compounds	157-163	erythropoietin	Homo sapiens	175-178
7577932-7	1995	Stabilization of NOS activity by GSH was augmented by protein disulfide isomerase (PDI), indicating that, at least in part, GSH acted by reductive protection of NOS protein thiols.	Sulfhydryl Compounds	173-179	prolyl 4-hydroxylase subunit beta	Homo sapiens	83-86
7671238-1	1995	Thioredoxin, a cellular thiol, functions as a self-defense mechanism in response to environmental stimuli, including oxidative stress.	Sulfhydryl Compounds	24-29	thioredoxin	Homo sapiens	0-11
7488239-8	1995	The transcript half-lives of another thiol-metabolism enzyme, gamma-glutamylcysteine synthetase (gamma-GCS), and a phase II detoxification enzyme, dihydrodiol dehydrogenase (DDH), were also increased in HT6-8, SKOV3 and DU145 cells treated with EA.	Sulfhydryl Compounds	37-42	glutamate-cysteine ligase catalytic subunit	Homo sapiens	62-95
8543371-5	1995	The thiol protease inhibitors E-64 and cystatin, as well as the thiol/serine inhibitors antipain and leupeptin, diminished only C5a-induced chemotaxis.	Sulfhydryl Compounds	4-9	complement C5a receptor 1	Homo sapiens	128-131
8838290-10	1995	In addition, more than 90% of the GPD activity in the VYS, but not the embryo, was rapidly inhibited by the thiol alkylating agent N-ethylmaleimide (NEM, 100 microM) within 15 min of the exposure.	Sulfhydryl Compounds	108-113	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	34-37
8547882-0	1995	Transition metal chemistry of main group hydrazides, Part 14: Evaluation of new Tc-99m chelates of thiol functionalized phosphorus hydrazides.	Sulfhydryl Compounds	99-104	TCDD inducible poly(ADP-ribose) polymerase	Homo sapiens	53-60
8547882-8	1995	The good in vitro and in vivo stability and high yields of the Tc-99m complexes of SL1 and SL2 indicate the potential hydrazido-thiols hold for use as a basis in formulating new Tc-99m radiopharmaceuticals, particularly when thiol moieties are used in conjunction with multi-functional phosphorous hydrazide compounds.	Sulfhydryl Compounds	128-133	matrix metallopeptidase 3	Homo sapiens	83-86
8547882-8	1995	The good in vitro and in vivo stability and high yields of the Tc-99m complexes of SL1 and SL2 indicate the potential hydrazido-thiols hold for use as a basis in formulating new Tc-99m radiopharmaceuticals, particularly when thiol moieties are used in conjunction with multi-functional phosphorous hydrazide compounds.	Sulfhydryl Compounds	128-133	matrix metallopeptidase 10	Homo sapiens	91-94
8838290-12	1995	Further experiments demonstrated that the activity of the GPD, inhibited by a 30-min incubation with 500 microM diamide, can be reversed after removal of diamide and that this effect was potentiated by subsequent treatment with dithiothreitol (30 mM), a thiol reducing agent.	Sulfhydryl Compounds	254-259	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	58-61
7548172-4	1995	Our laboratory has, however, demonstrated that two thiol sites within LCAT can become fatty acylated following lecithin cleavage although this does not appear to be essential for catalysis.	Sulfhydryl Compounds	51-56	lecithin-cholesterol acyltransferase	Homo sapiens	70-74
7547955-6	1995	The pH dependence of the dissociation constant suggests the alpha-amine of the amino acid must be unprotonated for nucleophilic attack at C4" of PLP, and an enzyme side chain must be unprotonated to hydrogen-bond the thiol or hydroxyl side chain of the amino acid.	Sulfhydryl Compounds	217-222	proteolipid protein 1	Homo sapiens	145-148
7547904-6	1995	The differences in activity between PDI and its thioredoxin-like domains suggest that other features of the PDI molecule are also required for its complete range of thiol-disulfide exchange activities.	Sulfhydryl Compounds	165-170	prolyl 4-hydroxylase subunit beta	Homo sapiens	36-39
7547904-6	1995	The differences in activity between PDI and its thioredoxin-like domains suggest that other features of the PDI molecule are also required for its complete range of thiol-disulfide exchange activities.	Sulfhydryl Compounds	165-170	prolyl 4-hydroxylase subunit beta	Homo sapiens	108-111
7548172-5	1995	In order to assess the ability of LCAT to donate a fatty acid derived from the sn-2 position of lecithin and present as an acyl enzyme intermediate (linked via an oxyester bond to Ser-181) to a sulfhydryl residue, we evaluated the ability of cholest-5-ene-3 beta-thiol to act as a substrate for cholesterol ester formation by LCAT.	Sulfhydryl Compounds	194-204	lecithin-cholesterol acyltransferase	Homo sapiens	34-38
7548180-10	1995	N-Ethylmaleimide (10 mM) markedly inhibited the purified enzyme, indicating the presence of free thiol groups on PLD.	Sulfhydryl Compounds	97-102	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	113-116
7654703-0	1995	Electron spin resonance and fluorescence studies of the conformational environment of the thiol groups of thrombospondin: interactions with thrombin.	Sulfhydryl Compounds	90-95	thrombospondin 1	Homo sapiens	106-120
7673130-3	1995	The IC50 of SNAP for GPx was 2 microM at 1 h of incubation and was 20% of the IC50 for another thiol enzyme, glyceraldehyde-3-phosphate dehydrogenase, in which a specific cysteine residue is known to be nitrosylated.	Sulfhydryl Compounds	95-100	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	109-149
7673133-12	1995	Of the 10 Cys residues in S100A3, 5 only are free thiols, and accessible to 5,5"-dithiobis(2-nitro-benzoic acid); they display a high reactivity in the metal-free and Ca2+ form, but a 20-fold lowered reactivity in the Zn2+ form of S100A3.	Sulfhydryl Compounds	50-56	S100 calcium binding protein A3	Homo sapiens	26-32
7669785-9	1995	Unlike native aldose reductase, which contains a thiol-sensitive Cys298, neither the I298C or V299C mutant exhibited any thiol sensitivity, suggesting a geometry of the active site pocket different from that in aldose reductase.	Sulfhydryl Compounds	49-54	aldo-keto reductase family 1 member B	Homo sapiens	14-30
7654778-0	1995	Gas-phase cigarette smoke inhibits plasma lecithin-cholesterol acyltransferase activity by modification of the enzyme"s free thiols.	Sulfhydryl Compounds	125-131	lecithin-cholesterol acyltransferase	Homo sapiens	42-78
7573405-7	1995	Consistent with this finding, GSNO-mediated GAPDH inhibition was reversible with low-molecular-weight thiols, and the reversal of inhibition correlated with the "denitrosylation" of GAPDH.	Sulfhydryl Compounds	102-108	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	44-49
7657637-4	1995	All the heterobifunctional reagents plus the homobifunctional arylhalide 1,5-difluoro-2,4-dinitrobenzene were effective in cross-linking the [3H]BK N terminus specifically to a sulfhydryl in the receptor, and this cross-linking occurred at 5-100 microM reagent.	Sulfhydryl Compounds	177-187	kininogen 1	Bos taurus	145-147
7654703-9	1995	ESR and fluorescence studies of thiol-labeled TSP indicate that the sulfhydryls are not affected in the noncovalent thrombin: TSP complex, although they must be playing a major role in the second step, i.e., formation of the covalent complex, through intermolecular thiol exchange.	Sulfhydryl Compounds	32-37	thrombospondin 1	Homo sapiens	46-49
7654703-0	1995	Electron spin resonance and fluorescence studies of the conformational environment of the thiol groups of thrombospondin: interactions with thrombin.	Sulfhydryl Compounds	90-95	coagulation factor II, thrombin	Homo sapiens	140-148
7654778-9	1995	Since LCAT contains two free cysteine residues (Cys-31 and -184) near the active site of the enzyme, we tested whether pretreatment of plasma with the reversible sulfhydryl modifying compound, 5,5"-dithiobis-2-nitrobenzoic acid (DTNB), could protect LCAT from CS-induced inhibition.	Sulfhydryl Compounds	162-172	lecithin-cholesterol acyltransferase	Homo sapiens	6-10
7654703-1	1995	The free thiols of platelet thrombospondin (TSP) were modified with thiol-specific spin labels and fluorescence probes.	Sulfhydryl Compounds	9-15	thrombospondin 1	Homo sapiens	28-42
7654703-1	1995	The free thiols of platelet thrombospondin (TSP) were modified with thiol-specific spin labels and fluorescence probes.	Sulfhydryl Compounds	9-15	thrombospondin 1	Homo sapiens	44-47
7654703-1	1995	The free thiols of platelet thrombospondin (TSP) were modified with thiol-specific spin labels and fluorescence probes.	Sulfhydryl Compounds	9-14	thrombospondin 1	Homo sapiens	28-42
7654703-1	1995	The free thiols of platelet thrombospondin (TSP) were modified with thiol-specific spin labels and fluorescence probes.	Sulfhydryl Compounds	9-14	thrombospondin 1	Homo sapiens	44-47
7654703-2	1995	The conformational effects of thrombin complexation with TSP were monitored by thiol-specific spin labels covalently attached to TSP and active site specific spin labels on thrombin.	Sulfhydryl Compounds	79-84	thrombospondin 1	Homo sapiens	57-60
7654703-3	1995	The results provide evidence supporting speculations that the thiols of the three polypeptide chains in TSP are not conformationally identical.	Sulfhydryl Compounds	62-68	thrombospondin 1	Homo sapiens	104-107
7639514-0	1995	Antioxidant paradoxes of phenolic compounds: peroxyl radical scavenger and lipid antioxidant, etoposide (VP-16), inhibits sarcoplasmic reticulum Ca(2+)-ATPase via thiol oxidation by its phenoxyl radical.	Sulfhydryl Compounds	163-168	host cell factor C1	Homo sapiens	105-110
7639514-3	1995	In the present work, we studied effects of phenoxyl radicals generated from a phenolic antitumor drug, Etoposide (VP-16), on oxidation of thiols and activity of Ca(2+)-ATPase in sarcoplasmic reticulum (SR) membranes from skeletal muscles.	Sulfhydryl Compounds	138-144	host cell factor C1	Homo sapiens	114-119
7639514-9	1995	Reduction of VP-16 phenoxyl radicals by ascorbate protected against AAPH- and tyrosinase-induced thiol oxidation and Ca(2+)-ATPase inhibition.	Sulfhydryl Compounds	97-102	host cell factor C1	Homo sapiens	13-18
7639514-10	1995	The results suggest that efficient phenolic scavengers of peroxyl radicals such as VP-16--which are commonly considered as potent antioxidants--may themselves produce oxidative stress due to secondary reactions of their phenoxyl radicals with thiols.	Sulfhydryl Compounds	243-249	host cell factor C1	Homo sapiens	83-88
7639707-7	1995	The NAD+ linkage to neuronal GAPDH measured in the presence of NO and superoxide probably involves sulphydryl groups, since the radiolabelling of the protein was reversed by exposure to HgCl2 and prevented by pretreatment with the alkylating agent N-ethylmaleimide.	Sulfhydryl Compounds	99-109	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	29-34
7481871-7	1995	The results suggest that IL-1 beta could effectively lessen the degree of stress-induced gastric mucosal damage, due possibly to the production of endogenous sulfhydryl compounds in the gastric mucosa.	Sulfhydryl Compounds	158-178	interleukin 1 beta	Rattus norvegicus	25-34
7626644-10	1995	Differential alkylation/peptide mapping/N-terminal sequence analyses show that a GLUT1 carboxyl-terminal peptide (residues 232-492) contains three inaccessible sulfhydryl groups and that an N-terminal GLUT1 peptide (residues 147-261/299) contains two accessible thiols.	Sulfhydryl Compounds	262-268	solute carrier family 2, facilitated glucose transporter member 1	Cricetulus griseus	81-86
7476933-5	1995	In contrast, thiol oxidizing or alkylating agents inhibited both NF-kappa B activation and elevated MnSOD expression in response to TNF alpha or IL-1.	Sulfhydryl Compounds	13-18	nuclear factor kappa B subunit 1	Homo sapiens	65-75
7615539-9	1995	Our data suggest that the biologic activity of ONOO- involves S-nitrosation of cellular thiols resulting in NO-mediated cyclic GMP accumulation.	Sulfhydryl Compounds	88-94	5'-nucleotidase, cytosolic II	Homo sapiens	127-130
7626020-9	1995	Like PGM from various vertebrate species, PGM activity from Paramecium can be fully re-established by addition of Glc-1,6-P2 at 10 nM, and it is also stimulated by bivalent cations and insensitive to chelating or thiol reagents.	Sulfhydryl Compounds	213-218	phosphoglucomutase-1	Oryctolagus cuniculus	42-45
7612622-1	1995	All 20 single cysteine substitution mutants in the sequence Y136-M155 of bovine rhodopsin have been prepared and modified with a sulfhydryl-specific nitroxide reagent.	Sulfhydryl Compounds	129-139	rhodopsin	Bos taurus	80-89
7615500-1	1995	Protein disulfide isomerase (PDI) alkylated at thiols of the thioredoxin-like -CHC- active sites is devoid of isomerase activity, but its chaperone-like activity to increase the reactivation yield and prevent the aggregation of guanidine hydrochloride-denatured D-glyceraldehyde-3-phosphate dehydrogenase upon dilution is unimpaired.	Sulfhydryl Compounds	47-53	prolyl 4-hydroxylase subunit beta	Homo sapiens	0-27
7615500-1	1995	Protein disulfide isomerase (PDI) alkylated at thiols of the thioredoxin-like -CHC- active sites is devoid of isomerase activity, but its chaperone-like activity to increase the reactivation yield and prevent the aggregation of guanidine hydrochloride-denatured D-glyceraldehyde-3-phosphate dehydrogenase upon dilution is unimpaired.	Sulfhydryl Compounds	47-53	prolyl 4-hydroxylase subunit beta	Homo sapiens	29-32
7608558-6	1995	Moreover, sCD38-mediated protein ribosylation was found to occur specifically at cysteine residues, since it was effectively blocked by addition of L-cysteine but not by other amino acids, and CD38-mediated protein ribosylation could be reversed by the addition of HgCl2, which specifically cleaves thiol-glycosidic bonds.	Sulfhydryl Compounds	299-304	CD38 molecule	Homo sapiens	11-15
7476933-0	1995	Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.	Sulfhydryl Compounds	0-5	tumor necrosis factor	Homo sapiens	20-29
7476933-0	1995	Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.	Sulfhydryl Compounds	0-5	interleukin 1 alpha	Homo sapiens	34-38
7476933-0	1995	Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.	Sulfhydryl Compounds	0-5	superoxide dismutase 2	Homo sapiens	47-52
7476933-0	1995	Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.	Sulfhydryl Compounds	0-5	nuclear factor kappa B subunit 1	Homo sapiens	87-97
7476933-5	1995	In contrast, thiol oxidizing or alkylating agents inhibited both NF-kappa B activation and elevated MnSOD expression in response to TNF alpha or IL-1.	Sulfhydryl Compounds	13-18	superoxide dismutase 2	Homo sapiens	100-105
7476933-4	1995	Activation of NF-kB and increased MnSOD expression were potentiated by thiol reducing agents.	Sulfhydryl Compounds	71-76	superoxide dismutase 2	Homo sapiens	34-39
7599127-0	1995	Thiol-specific biotinylation of the insulin receptor in permeabilized cells enhances receptor function.	Sulfhydryl Compounds	0-5	insulin receptor	Cricetulus griseus	36-52
7599127-1	1995	We examined the reactivity of insulin receptor sulfhydryls to biotinylation in Chinese hamster ovary cells that express high levels of human insulin receptors (CHO/HIRc cells).	Sulfhydryl Compounds	47-58	insulin receptor	Cricetulus griseus	30-46
7476933-5	1995	In contrast, thiol oxidizing or alkylating agents inhibited both NF-kappa B activation and elevated MnSOD expression in response to TNF alpha or IL-1.	Sulfhydryl Compounds	13-18	tumor necrosis factor	Homo sapiens	132-141
7476933-5	1995	In contrast, thiol oxidizing or alkylating agents inhibited both NF-kappa B activation and elevated MnSOD expression in response to TNF alpha or IL-1.	Sulfhydryl Compounds	13-18	interleukin 1 alpha	Homo sapiens	145-149
7599127-4	1995	In cells expressing large numbers of IGF-1 receptors, the same technique enabled the detection of thiol-biotinylated IGF-1 receptors as well.	Sulfhydryl Compounds	98-103	insulin-like growth factor I	Cricetulus griseus	37-42
7599127-4	1995	In cells expressing large numbers of IGF-1 receptors, the same technique enabled the detection of thiol-biotinylated IGF-1 receptors as well.	Sulfhydryl Compounds	98-103	insulin-like growth factor I	Cricetulus griseus	117-122
7476933-10	1995	Likewise, some of the thiol modifying compounds inhibited AP-1 activation by TNF alpha or IL-1, whereas others did not.	Sulfhydryl Compounds	22-27	tumor necrosis factor	Homo sapiens	77-86
7476933-10	1995	Likewise, some of the thiol modifying compounds inhibited AP-1 activation by TNF alpha or IL-1, whereas others did not.	Sulfhydryl Compounds	22-27	interleukin 1 alpha	Homo sapiens	90-94
7619057-4	1995	The availability of the recombinant enzyme permitted the determination of such chemical properties as epsilon 280 (48,960), zinc content (2 atom/molecule) and available thiol content (8-10/molecule) for TOP.	Sulfhydryl Compounds	169-174	thimet oligopeptidase 1	Rattus norvegicus	203-206
7578366-3	1995	A potentially biodegradable linkage was formed between vitamin B12 and G-CSF by reaction of the buried thiol in G-CSF with a long chain dithiopyridyl derivative of vitamin B12.	Sulfhydryl Compounds	103-108	colony stimulating factor 3	Homo sapiens	71-76
7578366-3	1995	A potentially biodegradable linkage was formed between vitamin B12 and G-CSF by reaction of the buried thiol in G-CSF with a long chain dithiopyridyl derivative of vitamin B12.	Sulfhydryl Compounds	103-108	colony stimulating factor 3	Homo sapiens	112-117
7767941-0	1995	Influence of thiols on the chlorinating effect of a myeloperoxidase system.	Sulfhydryl Compounds	13-19	myeloperoxidase	Homo sapiens	52-67
8527265-3	1995	The thiol containing ACE inhibitor, captopril has been reported to inhibit isolated NADPH oxidase.	Sulfhydryl Compounds	4-9	angiotensin I converting enzyme	Homo sapiens	21-24
7767941-1	1995	The structure-activity relationships for the interactions of a number of sulfhydryl compounds on the transformation of (Z)-3-(4-bromophenyl)-3-(3-pyridyl)allylamine (CPP 200) by an MPO-H2O2-Cl-(-)system at pH 5.25 have been studied.	Sulfhydryl Compounds	73-93	myeloperoxidase	Homo sapiens	181-184
8948462-5	1995	Treatment of recombinant pNR-2/pS2 proteins with various thiol-group-reactive reagents indicated that cysteine is the most effective at producing recombinant pNR-2/pS2 that co-migrates with pNR-2/pS2 secreted by breast-cancer cells.	Sulfhydryl Compounds	57-62	trefoil factor 1	Homo sapiens	158-163
8948462-5	1995	Treatment of recombinant pNR-2/pS2 proteins with various thiol-group-reactive reagents indicated that cysteine is the most effective at producing recombinant pNR-2/pS2 that co-migrates with pNR-2/pS2 secreted by breast-cancer cells.	Sulfhydryl Compounds	57-62	trefoil factor 1	Homo sapiens	164-167
8948462-3	1995	The heterogeneity was reduced by treatment with thiol-group-containing reagents, suggesting that it is caused by the odd number of cysteine residues in mature pNR-2/pS2, and this view was reinforced by mutation of the extra-trefoil domain cysteine residue, Cys58, to a serine residue.	Sulfhydryl Compounds	48-53	trefoil factor 1	Homo sapiens	159-164
7743507-14	1995	However, intracellular thiol levels appear to influence the expression of c-fos and c-jun, suggesting a redox-sensitive component in the signaling cascade which modulates gene expression of c-fos and c-jun by asbestos.	Sulfhydryl Compounds	23-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-79
8948462-3	1995	The heterogeneity was reduced by treatment with thiol-group-containing reagents, suggesting that it is caused by the odd number of cysteine residues in mature pNR-2/pS2, and this view was reinforced by mutation of the extra-trefoil domain cysteine residue, Cys58, to a serine residue.	Sulfhydryl Compounds	48-53	trefoil factor 1	Homo sapiens	165-168
8948462-5	1995	Treatment of recombinant pNR-2/pS2 proteins with various thiol-group-reactive reagents indicated that cysteine is the most effective at producing recombinant pNR-2/pS2 that co-migrates with pNR-2/pS2 secreted by breast-cancer cells.	Sulfhydryl Compounds	57-62	trefoil factor 1	Homo sapiens	25-30
8948462-5	1995	Treatment of recombinant pNR-2/pS2 proteins with various thiol-group-reactive reagents indicated that cysteine is the most effective at producing recombinant pNR-2/pS2 that co-migrates with pNR-2/pS2 secreted by breast-cancer cells.	Sulfhydryl Compounds	57-62	trefoil factor 1	Homo sapiens	31-34
8948462-5	1995	Treatment of recombinant pNR-2/pS2 proteins with various thiol-group-reactive reagents indicated that cysteine is the most effective at producing recombinant pNR-2/pS2 that co-migrates with pNR-2/pS2 secreted by breast-cancer cells.	Sulfhydryl Compounds	57-62	trefoil factor 1	Homo sapiens	158-163
8948462-5	1995	Treatment of recombinant pNR-2/pS2 proteins with various thiol-group-reactive reagents indicated that cysteine is the most effective at producing recombinant pNR-2/pS2 that co-migrates with pNR-2/pS2 secreted by breast-cancer cells.	Sulfhydryl Compounds	57-62	trefoil factor 1	Homo sapiens	164-167
7750456-0	1995	Drosophila insulin receptor: lectin-binding properties and a role for oxidation-reduction of receptor thiols in activation.	Sulfhydryl Compounds	102-108	Insulin-like receptor	Drosophila melanogaster	0-27
7750456-7	1995	The ability of low concentrations of DTT to deactivate the DIR kinase suggests that, like the mammalian receptor, beta-subunit thiols may be involved in regulation of conformational changes between activated and unactivated receptor states.	Sulfhydryl Compounds	127-133	arginine vasopressin receptor 2	Homo sapiens	59-62
7654490-4	1995	Captopril (a thiol angiotensin-converting enzyme (ACE) inhibitor) and MPG (a simple thiol) were observed to abolish hypoxanthine/xanthine oxidase induced chemiluminescence.	Sulfhydryl Compounds	13-18	N-methylpurine DNA glycosylase	Homo sapiens	70-73
7654490-5	1995	The reactivity of captopril and MPG towards O2-/H2O2 was then determined by measurement of thiol oxidation in captopril and MPG after their incubation with hypoxanthine/xanthine oxidase.	Sulfhydryl Compounds	91-96	N-methylpurine DNA glycosylase	Homo sapiens	32-35
7490267-8	1995	But intracellular gp160 processing was inhibited only by permeable, low molecular mass inhibitors of VEM, such as DFP, E-64, and thiol reagents.	Sulfhydryl Compounds	129-134	glutamyl aminopeptidase	Homo sapiens	18-23
7743507-14	1995	However, intracellular thiol levels appear to influence the expression of c-fos and c-jun, suggesting a redox-sensitive component in the signaling cascade which modulates gene expression of c-fos and c-jun by asbestos.	Sulfhydryl Compounds	23-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	190-195
7663350-3	1995	Complementing these techniques with quantitative sulfhydryl assays, we discovered that the four cysteines present in rCAS form two intramolecular disulfide bonds.	Sulfhydryl Compounds	49-59	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	117-121
7771788-5	1995	In the presence of various pyridine nucleotide-dependent substrates, mitochondria are able to reduce the disulfide 5,5"-dithiobis (2-nitrobenzoic acid) (DTNB) to an extent far larger than that calculated from the theoretical amount of total mitochondrial thiol groups, indicating the occurrence of a catalytic system.	Sulfhydryl Compounds	255-260	dystrobrevin, beta	Rattus norvegicus	153-157
7668373-5	1995	Coefficient of variations for the various thiols measured by the NPM method range from 1.5 to 8.8%.	Sulfhydryl Compounds	42-48	nucleophosmin 1	Homo sapiens	65-68
7626706-2	1995	In the present study, the number and molecular localization of free sulfhydryls in the major proteins of human sperm chromatin, protamines P1 and P2, were determined by alkylation of reactive thiols with 14C-iodoacetamide, isolation of protamines, and peptide mapping.	Sulfhydryl Compounds	192-198	protamine 1	Homo sapiens	139-148
7733970-3	1995	The enzyme was inhibited by metal ion chelators and thiol-reactive agents, as well as a specific EP 24.15 inhibitor (N-[1(R,S)-carboxy-3-phenylpropyl]-Ala-Ala-Tyr-p-aminobenzoate), thus confirming the enzyme as a thiol-dependent metalloendopeptidase.	Sulfhydryl Compounds	213-218	thimet oligopeptidase 1	Rattus norvegicus	97-105
7744070-15	1995	(Tokyo) 114, 421-431] highly thermostable chloroplast C. reinhardtii thioredoxin m that is involved in the thiol-redox enzymic control of photosynthetic intermediate carbon metabolism.	Sulfhydryl Compounds	107-112	thioredoxin	Homo sapiens	69-80
7713918-5	1995	The results indicate that modification of FucT-V by 5,5"-dithiobis(2-nitrobenzoic acid) resulted in efficient enzyme inactivation that could be reversed by excess thiol reagent suggesting that the free sulfhydral group on the enzyme was required for activity.	Sulfhydryl Compounds	163-168	fucosyltransferase 5	Homo sapiens	42-48
7544669-5	1995	In an attempt to answer this question, the reactivity of the thiol group in human serum albumin (HSA) toward N-ethyl-3-(2-pyridyldisulfanyl)propionamide dextran was used as a model system to evaluate its correlation with the lyotropic series.	Sulfhydryl Compounds	61-66	albumin	Homo sapiens	82-95
7718580-2	1995	The kinetic reactivities of Zn(II) complexes of MT-3 with the chelator ethylenediaminetetraacetic acid (EDTA) or the thiol reagent dithiobis(2-nitrobenzoic acid) (DTNB) resembles the reactivity of ZnMT-1.	Sulfhydryl Compounds	117-122	metallothionein 3	Homo sapiens	48-52
7655415-4	1995	Glucose 6-phosphate dehydrogenase in rat liver microsomes was inactivated by ebselen, accompanied by a slight decrease in the thiol groups of microsomal membrane protein.	Sulfhydryl Compounds	126-131	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-33
7716769-7	1995	To substantiate this hypothesis, we compared interactions of the phenoxyl radicals generated from VP-16 and PMC with intracellular thiols in K562 cell homogenates.	Sulfhydryl Compounds	131-137	host cell factor C1	Homo sapiens	98-103
7607137-6	1995	We conclude that induction of a functional CYP1A1 monooxygenase by TCDD stimulates a pathway that generates thiol-sensitive reactive oxygen intermediates which, in turn, are responsible for the TCDD-dependent activation of genes linked to the LTR.	Sulfhydryl Compounds	108-113	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
7535236-0	1995	Tenascin-C induction in Whitlock-Witte culture: a relevant role of the thiol moiety in lymphoid-lineage differentiation.	Sulfhydryl Compounds	71-76	tenascin C	Mus musculus	0-10
7535236-5	1995	Furthermore, the reduced glutathione, which, like 2-ME, contains a thiol moiety, induced tenascin-C glycoprotein and its mRNA.	Sulfhydryl Compounds	67-72	tenascin C	Mus musculus	89-99
7592560-5	1995	High concentrations of dihydropteridine reductase also caused an apparent activation of NOS and was capable of replacing thiols.	Sulfhydryl Compounds	121-127	quinoid dihydropteridine reductase	Rattus norvegicus	23-49
7897207-9	1995	Intracellular adult T cell leukemia-derived factor/human thioredoxin, another thiol-related antioxidant protein, was oxidized by incubation with diamide.	Sulfhydryl Compounds	78-83	thioredoxin	Homo sapiens	57-68
7716769-0	1995	Phenoxyl radicals of etoposide (VP-16) can directly oxidize intracellular thiols: protective versus damaging effects of phenolic antioxidants.	Sulfhydryl Compounds	74-80	host cell factor C1	Homo sapiens	32-37
7716769-8	1995	While the PMC phenoxyl radicals were only slightly affected by thiols, the VP-16 phenoxyl radicals were reduced by thiols.	Sulfhydryl Compounds	115-121	host cell factor C1	Homo sapiens	75-80
7702570-2	1995	Analogue studies indicate a specific requirement for the thiol group of MMI for inactivation of LPO in the presence of H2O2.	Sulfhydryl Compounds	57-62	lactoperoxidase	Homo sapiens	96-99
7698341-3	1995	Thiol-reactive HgCl2, a multi-potent crosslinker of cell membrane proteins, induced heavy aggregation of Thy-1, a representative GPI-anchored protein, on murine thymocytes, and delivered a signal to induce heavy tyrosine phosphorylation of cellular proteins.	Sulfhydryl Compounds	0-5	thymus cell antigen 1, theta	Mus musculus	105-110
7737183-0	1995	X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors.	Sulfhydryl Compounds	96-101	matrix metallopeptidase 8	Homo sapiens	26-48
7820882-6	1995	After fractionation of cytosol, factors A and B required the presence of the thiol- reducing agent, dithioerythritol, for their activity; factor B more so than factor A.	Sulfhydryl Compounds	77-82	general transcription factor III A	Rattus norvegicus	32-47
7702578-1	1995	Native human insulin receptor (hIR) has been reported to contain only one free thiol group proposed to lie near the ATP-binding.	Sulfhydryl Compounds	79-84	insulin receptor	Homo sapiens	13-29
7702578-1	1995	Native human insulin receptor (hIR) has been reported to contain only one free thiol group proposed to lie near the ATP-binding.	Sulfhydryl Compounds	79-84	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	31-34
7702578-15	1995	Our findings indicate that the stoicheiometry of a single free thiol group/mol of insulin-binding activity noted in previous studies is either spread fractionally over a number of the cytoplasmic cysteines or is one of the four cysteines in the ectodomain of the hIR beta-subunit.	Sulfhydryl Compounds	63-68	insulin	Cricetulus griseus	82-89
7702578-15	1995	Our findings indicate that the stoicheiometry of a single free thiol group/mol of insulin-binding activity noted in previous studies is either spread fractionally over a number of the cytoplasmic cysteines or is one of the four cysteines in the ectodomain of the hIR beta-subunit.	Sulfhydryl Compounds	63-68	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	263-266
7788289-0	1995	Thioredoxin structure and mechanism: conformational changes on oxidation of the active-site sulfhydryls to a disulfide.	Sulfhydryl Compounds	92-103	thioredoxin	Homo sapiens	0-11
7897659-3	1995	The recent finding that the EUG1 protein, a PDI-related yeast protein, with C-X-X-S sequence at its active sites can complement PDI-deficiency raised the general question of whether disulfide-isomerase activity is essential for cell viability or whether PDI variants with single active-site thiol groups can be catalytically active as disulfide isomerases.	Sulfhydryl Compounds	291-296	protein disulfide isomerase EUG1	Saccharomyces cerevisiae S288C	28-32
7710634-0	1995	Tyrosinase-mediated cytotoxicity of 4-substituted phenols: quantitative structure-thiol-reactivity relationships of the derived o-quinones.	Sulfhydryl Compounds	82-87	tyrosinase	Homo sapiens	0-10
7757200-4	1995	As a result of Cu(II)/H2O2 treatment, the number of titrated thiols in LADH decreased from 6 to 1 per subunit.	Sulfhydryl Compounds	61-67	dihydrolipoamide dehydrogenase	Sus scrofa	71-75
7756555-1	1995	To gain insight into the secondary structure of the ion conduction pathway of a voltage-gated K+ channel, we used sulfhydryl-specific reagents of different diameters to probe amino acid side-chain accessibilities in the pore of the channel after cysteine-substitution mutagenesis.	Sulfhydryl Compounds	114-124	potassium voltage-gated channel subfamily D member 3	Homo sapiens	80-104
7756555-5	1995	The smaller thiol reagent Cd2+ reacts with modified side chains that are also accessible to the larger (2-trimethylammoniumethyl)methanethiosulfate (MTSET) [corrected].	Sulfhydryl Compounds	12-17	CD2 molecule	Homo sapiens	26-29
7619884-2	1995	Analytical methodology employing derivatization of SPC-100270 with o-phthaldialdehyde (OPA) and a chiral thiol, N-acetyl-D-penicillamine, was developed to assess the isomeric purity of SPC-100270 in the presence of two of its three stereoisomers.	Sulfhydryl Compounds	105-110	proline rich protein gene cluster	Homo sapiens	51-54
7876306-6	1995	We demonstrate that the difference between ISC and control beta-actin is the inaccessibility of two cysteine residues in ISC beta-actin to labeling by thiol reactive reagents; due to the formation of a disulfide bridge between cysteine284 and cysteine373 in ISC beta-actin, or alternatively another modification of cysteine284 and cysteine373 which is reversible with DTT and adds less than 100 D to the molecular weight of beta-actin.	Sulfhydryl Compounds	151-156	POTE ankyrin domain family member F	Homo sapiens	59-69
7876306-6	1995	We demonstrate that the difference between ISC and control beta-actin is the inaccessibility of two cysteine residues in ISC beta-actin to labeling by thiol reactive reagents; due to the formation of a disulfide bridge between cysteine284 and cysteine373 in ISC beta-actin, or alternatively another modification of cysteine284 and cysteine373 which is reversible with DTT and adds less than 100 D to the molecular weight of beta-actin.	Sulfhydryl Compounds	151-156	POTE ankyrin domain family member F	Homo sapiens	125-135
7876306-6	1995	We demonstrate that the difference between ISC and control beta-actin is the inaccessibility of two cysteine residues in ISC beta-actin to labeling by thiol reactive reagents; due to the formation of a disulfide bridge between cysteine284 and cysteine373 in ISC beta-actin, or alternatively another modification of cysteine284 and cysteine373 which is reversible with DTT and adds less than 100 D to the molecular weight of beta-actin.	Sulfhydryl Compounds	151-156	POTE ankyrin domain family member F	Homo sapiens	125-135
7876306-6	1995	We demonstrate that the difference between ISC and control beta-actin is the inaccessibility of two cysteine residues in ISC beta-actin to labeling by thiol reactive reagents; due to the formation of a disulfide bridge between cysteine284 and cysteine373 in ISC beta-actin, or alternatively another modification of cysteine284 and cysteine373 which is reversible with DTT and adds less than 100 D to the molecular weight of beta-actin.	Sulfhydryl Compounds	151-156	POTE ankyrin domain family member F	Homo sapiens	125-135
7861176-1	1995	Studies with thiol-modifying reagents have suggested that cysteines might play important roles in the function of the dopamine transporter (DAT).	Sulfhydryl Compounds	13-18	solute carrier family 6 member 3	Homo sapiens	118-138
7861176-1	1995	Studies with thiol-modifying reagents have suggested that cysteines might play important roles in the function of the dopamine transporter (DAT).	Sulfhydryl Compounds	13-18	solute carrier family 6 member 3	Homo sapiens	140-143
7861176-2	1995	To identify DAT cysteines with important thiol groups, we have studied six mutant dopamine transporters in which cysteines were replaced by alanines.	Sulfhydryl Compounds	41-46	solute carrier family 6 member 3	Homo sapiens	12-15
7861176-7	1995	Conceivably, they might also provide the targets for the influences of thiol-modifying reagents in modifying the function of the wild-type DAT expressed in striatal membranes.	Sulfhydryl Compounds	71-76	solute carrier family 6 member 3	Homo sapiens	139-142
7862635-7	1995	gamma IIH has a lower thiol content than gamma II and is not formed in the presence of dithiothreitol.	Sulfhydryl Compounds	22-27	G protein subunit gamma 7	Bos taurus	0-8
7876101-3	1995	In contrast, Hg2+, which may not only oxidize thiol groups but also form chelates with dibasic amino acids, caused a use-dependent, positive regulation of IsK.	Sulfhydryl Compounds	46-51	potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog	Xenopus laevis	155-158
7533153-1	1995	A number of thiol-reactive agents induce repetitive Ca2+ spiking in cells by a mechanism thought to involve sensitization of the inositol 1,4,5-trisphosphate receptor (IP3R).	Sulfhydryl Compounds	12-17	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	168-172
7862635-8	1995	We conclude that gamma IIH is a thiol oxidation product of gamma II-crystallin and is a dimer containing an intermolecular disulfide crosslink.	Sulfhydryl Compounds	32-37	G protein subunit gamma 7	Bos taurus	17-25
7836437-5	1995	The enzyme is inhibited by chelating agents and some thiol-blocking compounds, but differs from thimet oligopeptidase in not being activated by thiol compounds.	Sulfhydryl Compounds	53-58	thimet oligopeptidase 1	Rattus norvegicus	96-117
7836437-5	1995	The enzyme is inhibited by chelating agents and some thiol-blocking compounds, but differs from thimet oligopeptidase in not being activated by thiol compounds.	Sulfhydryl Compounds	144-149	thimet oligopeptidase 1	Rattus norvegicus	96-117
7532384-6	1995	Dithiothreitol, a thiol antioxidant, reduced TNF alpha induction of NOS.	Sulfhydryl Compounds	18-23	tumor necrosis factor	Rattus norvegicus	45-54
7532583-1	1995	The thiol-modifying reagent methyl methanethiosulfonate reacts with the cysteine residues of thiol esters released upon treatment of human alpha 2-macroglobulin with methylamine.	Sulfhydryl Compounds	4-9	alpha-2-macroglobulin	Homo sapiens	139-160
7835299-9	1995	We could increase GHBP release with a membrane impermeable thiol blocker, suggesting activation of a membrane protease.	Sulfhydryl Compounds	59-64	growth hormone receptor	Homo sapiens	18-22
7532583-6	1995	Protection of trypsin against inhibition by soybean trypsin inhibitor is significantly better when alpha 2-macroglobulin is modified by methylamine and methylmethanethiosulfonate than when it is modified by dinitrophenyl thiocyanate, which cyanylates the exposed thiol group.	Sulfhydryl Compounds	263-268	alpha-2-macroglobulin	Homo sapiens	99-120
7745546-7	1995	MMP-9 was at least partially activated by all protein-thiol group reactants and rather resistant to oxidative inhibition by hypochlorite (NaOCl); in contrast, MMP-2 was activated by APMA but not at all by gold thioglucose (GTG) and was clearly inactivated by hypochlorite (NaOCl).	Sulfhydryl Compounds	54-59	matrix metallopeptidase 9	Homo sapiens	0-5
7835277-1	1995	The membrane permeant thiol reagent diazene dicarboxylic acid bis-(N"-methylpiperazide) (DIP) has been shown to inhibit insulin secretion and Ca2+ uptake in pancreatic B cells in the presence of a stimulating glucose concentration (20 mM), whereas the nonpenetrating analog of DIP (bis-N"-methyliodide; DIP + 2) stimulates insulin release and Ca2+ uptake at a low glucose concentration (3 mM).	Sulfhydryl Compounds	22-27	disco interacting protein 2 homolog A	Mus musculus	303-310
7704183-1	1995	Scavenging of superoxide radical by angiotensin converting enzyme (ACE) inhibitor captopril (CAP), a thiol compound, was studied by several investigators and the results were contradictory; while some reported a high superoxide scavenging activity of CAP others found that CAP removed superoxide inefficiently.	Sulfhydryl Compounds	101-106	angiotensin I converting enzyme	Homo sapiens	36-65
7704183-1	1995	Scavenging of superoxide radical by angiotensin converting enzyme (ACE) inhibitor captopril (CAP), a thiol compound, was studied by several investigators and the results were contradictory; while some reported a high superoxide scavenging activity of CAP others found that CAP removed superoxide inefficiently.	Sulfhydryl Compounds	101-106	angiotensin I converting enzyme	Homo sapiens	67-70
7822317-1	1995	To gain insight into the abnormal phosphorylation of PHF-tau, we have determined the phosphorylation sites by identifying phosphopeptides by means of ion spray mass spectrometry followed by sequencing of ethane-thiol-modified peptides.	Sulfhydryl Compounds	211-216	microtubule associated protein tau	Homo sapiens	53-60
8527494-8	1995	Quantitative estimation of N-chloramine sensitive plasma thiols has been identified as an effective surrogate measure of leucocyte poly ADPRT.	Sulfhydryl Compounds	57-63	poly(ADP-ribose) polymerase 1	Homo sapiens	136-141
7747533-3	1995	The structure of the thiol adducts was determined by spectroscopic methods, addition being found to occur at C-2.	Sulfhydryl Compounds	21-26	complement C2	Homo sapiens	109-112
7484423-6	1995	For instance, some AT2 receptors are regulated by guanine nucleotides and sulfhydryl-reducing agents, whereas others are insensitive.	Sulfhydryl Compounds	74-84	angiotensin II receptor type 2	Homo sapiens	19-22
7651222-0	1995	Glucocorticoid receptor thiols and steroid-binding activity.	Sulfhydryl Compounds	24-30	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-23
7540026-19	1995	Modification of GAPDH is probably just one interesting target related to NO-redox chemistry and active-site thiol modification.	Sulfhydryl Compounds	108-113	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	16-21
7598952-4	1995	By contrast, the analogue containing only two photoreactive groups in positions 9 and 13, [Trp(Naps)9, Pap13]-alpha-MSH, produced long-lasting receptor stimulation which was not altered by the thiol reagent.	Sulfhydryl Compounds	193-198	alpha-msh	Anolis carolinensis	110-119
7540026-0	1995	Protein thiol modification of glyceraldehyde-3-phosphate dehydrogenase as a target for nitric oxide signaling.	Sulfhydryl Compounds	8-13	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	30-70
7797250-1	1995	Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation.	Sulfhydryl Compounds	71-76	thioredoxin	Homo sapiens	0-36
7797250-1	1995	Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation.	Sulfhydryl Compounds	71-76	thioredoxin	Homo sapiens	38-41
7797250-1	1995	Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation.	Sulfhydryl Compounds	71-76	thioredoxin	Homo sapiens	49-60
7797250-1	1995	Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation.	Sulfhydryl Compounds	71-76	thioredoxin	Homo sapiens	62-65
7891026-3	1995	The enzyme responsible had a pH optimum of approximately 7.0, was inhibited by serine (di-isopropyl flurophosphate) and thiol (N-ethylmaleimide) protease inhibitors, bacitracin and concentrations of Zn2+ naturally present in seminal plasma: these functional reagents are all known to be potent inhibitors of prolyl endopeptidase.	Sulfhydryl Compounds	120-125	prolyl endopeptidase	Homo sapiens	308-328
7476356-0	1995	Measurement of equilibrium midpoint potentials of thiol/disulfide regulatory groups on thioredoxin-activated chloroplast enzymes.	Sulfhydryl Compounds	50-55	thioredoxin	Homo sapiens	87-98
7550551-2	1995	In case of SIN-1 generation of nitrites run in parallel to disappearance of sulfhydryl groups of N-acetylcysteine and glutathione, however, for a pair of SIN-1 and cysteine the rate of formation of nitrites was much slower than the rate of consumption of sulfhydryl groups.	Sulfhydryl Compounds	76-86	MAPK associated protein 1	Homo sapiens	11-16
8604436-2	1995	Redox signalling pathways provide a link between external stimuli, through the flavoenzyme-mediated NADPH-dependent reduction of intracellular peptide thiols, such as glutathione, thioredoxin, glutaredoxin, and redox factor-1, to the posttranslational redox modification of certain intracellular proteins.	Sulfhydryl Compounds	151-157	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	211-225
7818492-4	1994	Samples of SASP were able to reductively depolymerize human immunoglobulin, a property shared with thioredoxin, a ubiquitous protein, almost identical to ADF, with an essential function in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	194-199	thioredoxin	Homo sapiens	11-15
7600893-5	1995	Sulfhydryl content correlated inversely with the activities of above three kinds of ATPase in kidney, but so did in brain positively.	Sulfhydryl Compounds	0-10	dynein axonemal heavy chain 8	Homo sapiens	84-90
7806531-12	1994	The results provide direct evidence for the existence of a functionally important complex between RyR1 and triadin whose stability is determined by the redox state of hyperreactive sulfhydryl moieties which are allosterically regulated by physiological and pharmacological channel ligands.	Sulfhydryl Compounds	181-191	ryanodine receptor 1	Homo sapiens	98-102
7818492-4	1994	Samples of SASP were able to reductively depolymerize human immunoglobulin, a property shared with thioredoxin, a ubiquitous protein, almost identical to ADF, with an essential function in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	194-199	thioredoxin	Homo sapiens	99-110
7818492-4	1994	Samples of SASP were able to reductively depolymerize human immunoglobulin, a property shared with thioredoxin, a ubiquitous protein, almost identical to ADF, with an essential function in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	194-199	thioredoxin	Homo sapiens	154-157
7818492-6	1994	The use of membrane-impermeable thiol reagents indicated that SASP was predominantly a cell-surface protein, and was not normally secreted.	Sulfhydryl Compounds	32-37	thioredoxin	Homo sapiens	62-66
7998986-9	1994	The presence of a thiol-reducing agent was required for Ca2+ mobilization by Z-Gly-Phe-NH2 but not by thapsigargin or Ins(1,4,5)P3.	Sulfhydryl Compounds	18-23	carbonic anhydrase 2	Rattus norvegicus	56-59
7983029-2	1994	The wild-type protein contains two redox active thiol/disulfide sites near the N and C terminus that are homologous to the redox center of thioredoxin.	Sulfhydryl Compounds	48-53	thioredoxin	Homo sapiens	139-150
7998927-1	1994	The effect of thiol compounds on the monophenolase activity of tyrosinase was investigated using 4-hydroxyanisole as the substrate and dithiothreitol (DTT) as the model thiol compound.	Sulfhydryl Compounds	14-19	tyrosinase	Homo sapiens	63-73
7957261-1	1994	The mammalian enzyme pantetheinase, which hydrolyzes pantetheine to pantothenic acid and cysteamine, is inhibited by many thiol reagents and activated by thiols.	Sulfhydryl Compounds	122-127	vanin 1	Homo sapiens	21-34
7957261-1	1994	The mammalian enzyme pantetheinase, which hydrolyzes pantetheine to pantothenic acid and cysteamine, is inhibited by many thiol reagents and activated by thiols.	Sulfhydryl Compounds	154-160	vanin 1	Homo sapiens	21-34
7996053-3	1994	We have used a photoreactive, thiol-cleavable, radiolabeled derivative of E. coli 0111:B4 LPS [LPS-(p-azidosalicylamido)-1,3"-dithiopropionamide; 125I-ASD-LPS], to identify the presence of LPS-binding proteins (LBPs) in bovine serum.	Sulfhydryl Compounds	30-35	interferon regulatory factor 6	Homo sapiens	90-93
7996053-3	1994	We have used a photoreactive, thiol-cleavable, radiolabeled derivative of E. coli 0111:B4 LPS [LPS-(p-azidosalicylamido)-1,3"-dithiopropionamide; 125I-ASD-LPS], to identify the presence of LPS-binding proteins (LBPs) in bovine serum.	Sulfhydryl Compounds	30-35	interferon regulatory factor 6	Homo sapiens	95-98
7996053-3	1994	We have used a photoreactive, thiol-cleavable, radiolabeled derivative of E. coli 0111:B4 LPS [LPS-(p-azidosalicylamido)-1,3"-dithiopropionamide; 125I-ASD-LPS], to identify the presence of LPS-binding proteins (LBPs) in bovine serum.	Sulfhydryl Compounds	30-35	interferon regulatory factor 6	Homo sapiens	95-98
7996053-3	1994	We have used a photoreactive, thiol-cleavable, radiolabeled derivative of E. coli 0111:B4 LPS [LPS-(p-azidosalicylamido)-1,3"-dithiopropionamide; 125I-ASD-LPS], to identify the presence of LPS-binding proteins (LBPs) in bovine serum.	Sulfhydryl Compounds	30-35	interferon regulatory factor 6	Homo sapiens	95-98
7895911-9	1994	Thiol active agents as well as metal chelators, both potent IDE blockers, inhibited also the insulin-degrading activity of the same sample.	Sulfhydryl Compounds	0-5	insulin degrading enzyme	Mus musculus	60-63
7998927-1	1994	The effect of thiol compounds on the monophenolase activity of tyrosinase was investigated using 4-hydroxyanisole as the substrate and dithiothreitol (DTT) as the model thiol compound.	Sulfhydryl Compounds	169-174	tyrosinase	Homo sapiens	63-73
8082232-0	1994	Catalytic effects of glutathione peroxidase mimetics on the thiol reduction of cytochrome c.	Sulfhydryl Compounds	60-65	cytochrome c, somatic	Homo sapiens	79-91
7961686-8	1994	The TPx disulfide is specifically reduced by thioredoxin, but can also be reduced (less effectively) by a small molecular size thiol.	Sulfhydryl Compounds	127-132	thyroid peroxidase	Homo sapiens	4-7
7888735-3	1994	The thiol adducts were separated on a reversed-phase C-18 column using acetonitrile: 0.05 M triethylammonium (TEA) phosphate (pH 4) solution 32:68 (v/v) as the mobile phase.	Sulfhydryl Compounds	4-9	prolyl 4-hydroxylase, transmembrane	Rattus norvegicus	126-130
8082232-1	1994	The reduction of ferric cytochrome c by various thiols was studied.	Sulfhydryl Compounds	48-54	cytochrome c, somatic	Homo sapiens	24-36
7937896-4	1994	Affinity chromatography was used to bind glutaredoxin on a glutathione-containing thiol-Sepharose column.	Sulfhydryl Compounds	82-87	glutaredoxin	Homo sapiens	41-53
7524677-7	1994	Eventually, testis cytosolic and membrane bound PHGPx showed the same substrate specificity for both peroxidic and thiol substrates.	Sulfhydryl Compounds	115-120	glutathione peroxidase 4	Rattus norvegicus	48-53
7957178-5	1994	The inhibition of binding IL5 to its receptor by the isothiazolone derivatives is abrogated by free-sulfhydryl-containing compounds such as dithiothreitol, indicating that the isothiazolones react with the sulfhydryl group of free cysteine residues in the hIL5R alpha.	Sulfhydryl Compounds	100-110	interleukin 5	Homo sapiens	26-29
7957178-5	1994	The inhibition of binding IL5 to its receptor by the isothiazolone derivatives is abrogated by free-sulfhydryl-containing compounds such as dithiothreitol, indicating that the isothiazolones react with the sulfhydryl group of free cysteine residues in the hIL5R alpha.	Sulfhydryl Compounds	100-110	interleukin 5 receptor subunit alpha	Homo sapiens	256-267
7835755-8	1994	Activity of glutathione reductase (GR) was decreased significantly in platelets and lungs with an increase in the total thiol groups in the lung homogenate.	Sulfhydryl Compounds	120-125	glutathione-disulfide reductase	Rattus norvegicus	12-33
7835755-8	1994	Activity of glutathione reductase (GR) was decreased significantly in platelets and lungs with an increase in the total thiol groups in the lung homogenate.	Sulfhydryl Compounds	120-125	glutathione-disulfide reductase	Rattus norvegicus	35-37
7980410-4	1994	When GSH levels in HepG2 cells were lowered, Epo production was more susceptible to H2O2-induced inhibition, indicating that H2O2 might affect thiol groups in regulatory proteins.	Sulfhydryl Compounds	143-148	erythropoietin	Homo sapiens	45-48
7866298-3	1994	The inactivated-G6PD is restored its activity by the treatment of thioltransferase with 1 mM cysteamine or reduced glutathione (GSH) much more effectively than only by thiols.	Sulfhydryl Compounds	168-174	glucose-6-phosphate dehydrogenase	Homo sapiens	16-20
7929168-3	1994	Low M(r) PTPase from bovine liver lost two out of eight thiol groups present in the molecule during the inactivation with sodium nitroprusside and with other NO-producing compounds.	Sulfhydryl Compounds	56-61	acid phosphatase 1	Bos taurus	9-15
7929168-6	1994	The NO-inactivated low M(r) PTPase was reactivated by treating the inactive enzyme with thiol-containing reagents.	Sulfhydryl Compounds	88-93	acid phosphatase 1	Bos taurus	28-34
7929187-10	1994	The thiols covalently bound to purified S-thiolated GAPDH were removed by dithioerythritol and were identified as glutathione and cysteine; glutathione was predominant.	Sulfhydryl Compounds	4-10	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	52-57
7929187-11	1994	These results indicate that during the respiratory burst in monocytes, low molecular weight thiols can bind to specific cytosolic proteins, including GAPDH.	Sulfhydryl Compounds	92-98	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	150-155
7944397-7	1994	The results show that vitamin K3 preferentially inhibits the effects of PKC activators on PLD-mediated hydrolysis of PtdEtn by a mechanism which may involve oxidation of thiols in a critically important regulatory component.	Sulfhydryl Compounds	170-176	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	90-93
7866298-3	1994	The inactivated-G6PD is restored its activity by the treatment of thioltransferase with 1 mM cysteamine or reduced glutathione (GSH) much more effectively than only by thiols.	Sulfhydryl Compounds	168-174	glutaredoxin	Homo sapiens	66-82
8001836-3	1994	In separate experiments, synaptosomal membranes were labeled with the thiol-specific spin label MTS ((1-oxyl-2,2,5,5-tetramethyl-pyrroline-3-methyl)-methanethiosulfonate), or the lipid-specific spin probe 5-NS (5-nitroxide stearate).	Sulfhydryl Compounds	70-75	spindlin 1	Homo sapiens	85-89
7842139-0	1994	Human (THP-1) macrophages oxidize LDL by a thiol-dependent mechanism.	Sulfhydryl Compounds	43-48	GLI family zinc finger 2	Homo sapiens	7-12
7929609-7	1994	Thiol compounds appeared to exert a supportive level in TIG-1 cells cultured in FBS, whereas protein synthesis inhibitors did not alter the reduced intracellular thiol content.	Sulfhydryl Compounds	0-5	retinoic acid receptor responder 1	Homo sapiens	56-61
8082769-2	1994	Reduction of the single, highly conserved intramolecular disulfide bond of chromogranin B by exposure of intact PC12 cells to the thiol reducing agent dithiothreitol has previously been shown to cause its missorting to the constitutive pathway of secretion.	Sulfhydryl Compounds	130-135	chromogranin B	Rattus norvegicus	75-89
7925967-3	1994	It is shown that spinach DHA reductase and soybean trypsin inhibitor are both capable of reducing dehydroascorbate when in the reduced (thiol) form but acquire trypsin-inhibiting activity in the oxidized (disulfide) state.	Sulfhydryl Compounds	136-141	kunitz trypsin protease inhibitor	Glycine max	51-68
7945407-2	1994	More than 90% of intravenously administered ebselen in mouse plasma is bound by selenium-sulfur bonds to reactive thiols in serum albumin.	Sulfhydryl Compounds	114-120	albumin	Mus musculus	124-137
7929074-4	1994	H2O2 treatment of DPDase decreased the number of thiol groups reactive with 5,5"-dithiobis(2-nitrobenzoate) from eight/subunit to less than one.	Sulfhydryl Compounds	49-54	dihydropyrimidine dehydrogenase	Homo sapiens	18-24
8083206-7	1994	A heterobifunctional sulfhydryl derivative of CaM (N-succinimidyl 3-(2-pyridyldithio)propionate-CaM) formed reducible cross-links with EF-1 alpha in solution but not with the complex of EF-1 alpha beta gamma.	Sulfhydryl Compounds	21-31	calmodulin	Oryctolagus cuniculus	46-49
8083206-7	1994	A heterobifunctional sulfhydryl derivative of CaM (N-succinimidyl 3-(2-pyridyldithio)propionate-CaM) formed reducible cross-links with EF-1 alpha in solution but not with the complex of EF-1 alpha beta gamma.	Sulfhydryl Compounds	21-31	calmodulin	Oryctolagus cuniculus	96-99
8092321-5	1994	The pretreatment with the donor of thiol groups NAC (300 mg/kg iv) potentiated the depressor response to captopril because blood pressure decreased from 172 +/- 3 to 139 +/- 4 mmHg (n = 6).	Sulfhydryl Compounds	35-40	X-linked Kx blood group	Homo sapiens	48-51
7845383-10	1994	Superfusion with Fe-Asc, did, however, lead to a slight decrease in the concentration of non-protein thiols and ATP and a large increase in the concentration of lipid peroxidation products.	Sulfhydryl Compounds	101-107	PYD and CARD domain containing	Rattus norvegicus	20-23
8083170-5	1994	In contrast to the uridyltransferase activity, which is quite stable and insensitive to thiol reagents, the acetyltransferase activity was rapidly lost when the enzyme was stored in the absence of reducing thiols or acetyl coenzyme A or was treated with thiol-alkylating agents, suggesting the presence of at least one essential cysteine residue in or near the active site.	Sulfhydryl Compounds	88-93	acetyltransferase	Escherichia coli	108-125
8083170-5	1994	In contrast to the uridyltransferase activity, which is quite stable and insensitive to thiol reagents, the acetyltransferase activity was rapidly lost when the enzyme was stored in the absence of reducing thiols or acetyl coenzyme A or was treated with thiol-alkylating agents, suggesting the presence of at least one essential cysteine residue in or near the active site.	Sulfhydryl Compounds	206-212	acetyltransferase	Escherichia coli	108-125
8083170-5	1994	In contrast to the uridyltransferase activity, which is quite stable and insensitive to thiol reagents, the acetyltransferase activity was rapidly lost when the enzyme was stored in the absence of reducing thiols or acetyl coenzyme A or was treated with thiol-alkylating agents, suggesting the presence of at least one essential cysteine residue in or near the active site.	Sulfhydryl Compounds	206-211	acetyltransferase	Escherichia coli	108-125
8037455-8	1994	(d) The RI, which showed sulfhydryl-dependent inhibitory activity on both secretory-type and nonsecretory-type ribonucleases, bound tightly to ribonuclease to form a 1:1 complex on a molar basis.	Sulfhydryl Compounds	25-35	ribonuclease/angiogenin inhibitor 1	Homo sapiens	8-10
8068642-13	1994	When VP-16 and tyrosinase were incubated in the presence of retina or hepatocyte homogenates, a two-phase lag period was observed by ESR for the appearance of the VP-16 radical signal: an ascorbate-dependent part (semidehydroascorbyl radical observable, sensitive to ascorbate oxidase) and thiol-dependent part (no radical signals in the spectra, sensitive to mersalyl acid).	Sulfhydryl Compounds	290-295	host cell factor C1	Homo sapiens	5-25
8076642-1	1994	Rotational dynamics and ordering of myosin heads in glycerinated skeletal muscle fibres were studied using an isothiocyanate-based spin label attached to the fast-reacting thiol sites of myosin and were compared with data obtained for maleimide and iodoacetamide spin labels attached to the same sites.	Sulfhydryl Compounds	172-177	myosin heavy chain 14	Homo sapiens	187-193
8067996-4	1994	At short labelling times with [3H]threonine, without chase, a monomeric thiol-reduction-resistant mucin precursor of apparent molecular mass &gt; 670 kDa was identified.	Sulfhydryl Compounds	72-77	LOC100508689	Homo sapiens	98-103
8067996-8	1994	With increasing chase time the precursor was replaced by thiol-reduction-sensitive mucin oligomers that reached peak intracellular radiolabelling with [3H]threonine by 2 h of chase, and then declined.	Sulfhydryl Compounds	57-62	LOC100508689	Homo sapiens	83-88
7953744-5	1994	In addition to rADF, incubation with two other thiol compounds, 2-mercaptoethanol (2-ME) and N-acetyl-L-cysteine (NAC), also increased the neuronal cell survival rate.	Sulfhydryl Compounds	47-52	X-linked Kx blood group	Homo sapiens	114-117
7953744-8	1994	Redox active molecules such as thiol compounds may be survival factors for central neurons in vitro, and this capacity may be supplied by endogenous molecules, such as ADF/TRX and glutathione, under certain pathologic conditions in vivo.	Sulfhydryl Compounds	31-36	thioredoxin	Homo sapiens	168-171
7953744-8	1994	Redox active molecules such as thiol compounds may be survival factors for central neurons in vitro, and this capacity may be supplied by endogenous molecules, such as ADF/TRX and glutathione, under certain pathologic conditions in vivo.	Sulfhydryl Compounds	31-36	thioredoxin	Homo sapiens	172-175
8050492-4	1994	The thiol:protein disulfide oxidoreductase activity of the purified mouse ERp61 was demonstrated by insulin-reduction assay.	Sulfhydryl Compounds	4-9	protein disulfide isomerase associated 3	Mus musculus	74-79
7913469-0	1994	The role of the thiol/disulfide centers and peptide binding site in the chaperone and anti-chaperone activities of protein disulfide isomerase.	Sulfhydryl Compounds	16-21	prolyl 4-hydroxylase subunit beta	Homo sapiens	115-142
8031794-0	1994	Inactivation of a cytosolic phospholipase A2 by thiol-modifying reagents: cysteine residues as potential targets of phospholipase A2.	Sulfhydryl Compounds	48-53	phospholipase A2 group IVA	Homo sapiens	18-44
8031794-0	1994	Inactivation of a cytosolic phospholipase A2 by thiol-modifying reagents: cysteine residues as potential targets of phospholipase A2.	Sulfhydryl Compounds	48-53	phospholipase A2 group IB	Homo sapiens	28-44
8031794-3	1994	In the absence of thiol reducing agents such as DTT, cPLA2 takes up only 2.8 equiv of [1-14C]iodoacetamide at pH 8.03/37 degrees C. With DTT present, cPLA2 is in its fully reduced form, and 4-5 equiv of acetamide are taken up without altering enzyme activity to give IA-cPLA2.	Sulfhydryl Compounds	18-23	phospholipase A2 group IVA	Homo sapiens	53-58
8034046-0	1994	Mechanism of covalent modification of glyceraldehyde-3-phosphate dehydrogenase at its active site thiol by nitric oxide, peroxynitrite and related nitrosating agents.	Sulfhydryl Compounds	98-103	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	38-78
8034046-1	1994	Previous studies have suggested that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes covalent modification of an active site thiol by a NO.-induced [32P]NAD(+)-dependent mechanism.	Sulfhydryl Compounds	136-141	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	37-77
8034046-1	1994	Previous studies have suggested that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) undergoes covalent modification of an active site thiol by a NO.-induced [32P]NAD(+)-dependent mechanism.	Sulfhydryl Compounds	136-141	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	79-84
8034046-7	1994	Peroxynitrite (ONOO-) also induces GAPDH modification in the presence of thiol, consistent with the notion that this species can transfer NO+ (or NO2+) through the intermediacy of RS-NO.	Sulfhydryl Compounds	73-78	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	35-40
8031126-15	1994	Also the cysteine residue of serum albumin was an efficient scavenger of C-radicals as shown by approximately 20% decrease in the protein scavenging activity after thiol alkylation.	Sulfhydryl Compounds	164-169	albumin	Homo sapiens	29-42
8037666-3	1994	The coincidence of the similar apparent optimum pH values of uncatalysed and PDI-catalysed reactions suggests that conditions favourable to spontaneous refolding of proteins may help PDI to catalyse thiol/disulphide interchange.	Sulfhydryl Compounds	199-204	prolyl 4-hydroxylase subunit beta	Homo sapiens	77-80
8037666-3	1994	The coincidence of the similar apparent optimum pH values of uncatalysed and PDI-catalysed reactions suggests that conditions favourable to spontaneous refolding of proteins may help PDI to catalyse thiol/disulphide interchange.	Sulfhydryl Compounds	199-204	prolyl 4-hydroxylase subunit beta	Homo sapiens	183-186
8037666-4	1994	Under the conditions described here no exogenously added dithiothreitol was required for PDI-catalysed renaturation, implying that the disulphide form of PDI was reduced to its active form by the free thiol groups in prochymosin molecules.	Sulfhydryl Compounds	201-206	prolyl 4-hydroxylase subunit beta	Homo sapiens	154-157
7798184-4	1994	These findings suggested that thioltransferase exerted regenerative effects on oxidatively damaged proteins like its cognate protein, thioredoxin, but with different substrate specificity, and their relative contribution to the regeneration reaction is dependent on the form of the oxidized thiols of the damaged proteins.	Sulfhydryl Compounds	291-297	glutaredoxin-1	Bos taurus	30-46
7798184-4	1994	These findings suggested that thioltransferase exerted regenerative effects on oxidatively damaged proteins like its cognate protein, thioredoxin, but with different substrate specificity, and their relative contribution to the regeneration reaction is dependent on the form of the oxidized thiols of the damaged proteins.	Sulfhydryl Compounds	291-297	thioredoxin	Bos taurus	134-145
8016303-4	1994	In all cases tested, if the thiol is toxic, the cell killing can be decreased or prevented by addition of catalase, consistent with the hypothesis that the toxicity is mediated through H2O2 produced during the thiol oxidation.	Sulfhydryl Compounds	28-33	catalase	Cricetulus griseus	106-114
7971909-2	1994	High insulin doses intensify lipid peroxidation, normalize the status of membranous proteins, reduce the number of thiol groups, reduce AOA level in membranes, and, hence, reduce membranous capacity to bind active peroxide radicals.	Sulfhydryl Compounds	115-120	insulin	Homo sapiens	5-12
8016303-4	1994	In all cases tested, if the thiol is toxic, the cell killing can be decreased or prevented by addition of catalase, consistent with the hypothesis that the toxicity is mediated through H2O2 produced during the thiol oxidation.	Sulfhydryl Compounds	210-215	catalase	Cricetulus griseus	106-114
8018729-1	1994	Glutaredoxin (thioltransferase) is a small, heat-stable protein, which is involved in thiol/disulfide exchange reactions.	Sulfhydryl Compounds	14-19	glutaredoxin	Homo sapiens	0-12
8024589-6	1994	These observations suggest that a thiol(s) may be involved in insulin receptor autophosphorylation in the juxtamembrane domain.	Sulfhydryl Compounds	34-39	insulin receptor	Homo sapiens	62-78
8194136-9	1994	GSH assays showed that treatment of U937 and Jurkat T-cells with NAC and OTC moderately increased the GSH level, while HC led to a significantly higher increase of the thiol level.	Sulfhydryl Compounds	168-173	X-linked Kx blood group	Homo sapiens	65-68
8016118-5	1994	In addition, a Cys residue that may be responsible for the thiol sensitivity of the insulinase and N-Arg dibasic convertase was proposed.	Sulfhydryl Compounds	59-64	insulin degrading enzyme	Rattus norvegicus	84-94
8207197-4	1994	In thiol-free cultures, an increase in intracellular free Ca2+ concentration and IL-2R alpha-chain/p 55 (Tac) induction was still observed, whereas transferrin receptor induction was markedly reduced, suggesting that the proliferative response of mitogenically stimulated PBMC was arrested in the late G1 phase in which transferrin receptor is induced.	Sulfhydryl Compounds	3-8	interleukin 2 receptor subunit alpha	Homo sapiens	81-92
8207197-4	1994	In thiol-free cultures, an increase in intracellular free Ca2+ concentration and IL-2R alpha-chain/p 55 (Tac) induction was still observed, whereas transferrin receptor induction was markedly reduced, suggesting that the proliferative response of mitogenically stimulated PBMC was arrested in the late G1 phase in which transferrin receptor is induced.	Sulfhydryl Compounds	3-8	interleukin 2 receptor subunit alpha	Homo sapiens	99-103
8207197-4	1994	In thiol-free cultures, an increase in intracellular free Ca2+ concentration and IL-2R alpha-chain/p 55 (Tac) induction was still observed, whereas transferrin receptor induction was markedly reduced, suggesting that the proliferative response of mitogenically stimulated PBMC was arrested in the late G1 phase in which transferrin receptor is induced.	Sulfhydryl Compounds	3-8	transferrin receptor	Homo sapiens	320-340
8207197-9	1994	Together with the fact that L-cystine transport is a limiting step in glutathione synthesis, these findings suggest that GSH and ADF might cooperate in the thiol-mediated redox regulation process and might also play key roles in cell cycle (late G1 to S) progression of activated lymphocytes.	Sulfhydryl Compounds	156-161	thioredoxin	Homo sapiens	129-132
7516183-1	1994	A wide variety of nucleotides are shown to bind to acidic fibroblast growth factor (aFGF) as demonstrated by their ability to (1) inhibit the heat-induced aggregation of the protein, (2) enhance the thermal stability of aFGF as monitored by both intrinsic fluorescence and CD, (3) interact with fluorescent nucleotides and displace a bound polysulfated naphthylurea compound, suramin, (4) reduce the size of heparin-aFGF complexes, and (5) protect a reactive aFGF thiol group.	Sulfhydryl Compounds	464-469	fibroblast growth factor 1	Bos taurus	51-82
7516183-1	1994	A wide variety of nucleotides are shown to bind to acidic fibroblast growth factor (aFGF) as demonstrated by their ability to (1) inhibit the heat-induced aggregation of the protein, (2) enhance the thermal stability of aFGF as monitored by both intrinsic fluorescence and CD, (3) interact with fluorescent nucleotides and displace a bound polysulfated naphthylurea compound, suramin, (4) reduce the size of heparin-aFGF complexes, and (5) protect a reactive aFGF thiol group.	Sulfhydryl Compounds	464-469	fibroblast growth factor 1	Bos taurus	84-88
7516183-1	1994	A wide variety of nucleotides are shown to bind to acidic fibroblast growth factor (aFGF) as demonstrated by their ability to (1) inhibit the heat-induced aggregation of the protein, (2) enhance the thermal stability of aFGF as monitored by both intrinsic fluorescence and CD, (3) interact with fluorescent nucleotides and displace a bound polysulfated naphthylurea compound, suramin, (4) reduce the size of heparin-aFGF complexes, and (5) protect a reactive aFGF thiol group.	Sulfhydryl Compounds	464-469	fibroblast growth factor 1	Bos taurus	220-224
7516183-1	1994	A wide variety of nucleotides are shown to bind to acidic fibroblast growth factor (aFGF) as demonstrated by their ability to (1) inhibit the heat-induced aggregation of the protein, (2) enhance the thermal stability of aFGF as monitored by both intrinsic fluorescence and CD, (3) interact with fluorescent nucleotides and displace a bound polysulfated naphthylurea compound, suramin, (4) reduce the size of heparin-aFGF complexes, and (5) protect a reactive aFGF thiol group.	Sulfhydryl Compounds	464-469	fibroblast growth factor 1	Bos taurus	220-224
7516183-1	1994	A wide variety of nucleotides are shown to bind to acidic fibroblast growth factor (aFGF) as demonstrated by their ability to (1) inhibit the heat-induced aggregation of the protein, (2) enhance the thermal stability of aFGF as monitored by both intrinsic fluorescence and CD, (3) interact with fluorescent nucleotides and displace a bound polysulfated naphthylurea compound, suramin, (4) reduce the size of heparin-aFGF complexes, and (5) protect a reactive aFGF thiol group.	Sulfhydryl Compounds	464-469	fibroblast growth factor 1	Bos taurus	220-224
8203918-10	1994	Active aconitase could be reconstituted from the purified IRE-BP obtained from the expression system by addition of iron, thiol, and sulfide, and the characteristic epr spectrum of the 3Fe form of cytosolic aconitase was obtained after ferricyanide oxidation of the reconstituted material.	Sulfhydryl Compounds	122-127	aconitase 1	Homo sapiens	58-64
8200453-0	1994	Kinetics and equilibria of S-nitrosothiol-thiol exchange between glutathione, cysteine, penicillamines and serum albumin.	Sulfhydryl Compounds	36-41	albumin	Homo sapiens	107-120
7514405-2	1994	The resulting free Cys residues (Cys-949) contain the only free thiol groups in alpha 2M.	Sulfhydryl Compounds	64-69	alpha-2-macroglobulin	Homo sapiens	80-88
8195144-2	1994	The presence of a cysteine residue(s) near the active site of acylpeptide hydrolase was suggested by inactivation of the enzyme with sulfhydryl-modifying agents and by the substantial protection against inactivation afforded by the competitive inhibitor acetylmethionine.	Sulfhydryl Compounds	133-143	acylaminoacyl-peptide hydrolase	Homo sapiens	62-83
7514405-6	1994	The slow thiol-disulfide exchange reaction that irreversibly stabilizes noncovalent growth factor-alpha 2M-methylamine complexes was completely inhibited by modification of Cys-949.	Sulfhydryl Compounds	9-14	alpha-2-macroglobulin	Homo sapiens	98-106
8180161-3	1994	Four extrinsic probes of the fast reactive sulfhydryl (SH1) on myosin subfragment 1 (S1) were employed.	Sulfhydryl Compounds	43-53	myosin heavy chain 14	Homo sapiens	63-69
8187884-4	1994	Treatment of HMG1 with a thiol-specific reagent, N-ethylmaleimide, inhibited the ability of the protein to induce DNA looping and compaction but not the electrostatic interaction with DNA.	Sulfhydryl Compounds	25-30	high mobility group box 1 pseudogene 5	Homo sapiens	13-17
8042190-1	1994	Human plasma Lp(a) is susceptible to various sulfhydryl compounds.	Sulfhydryl Compounds	45-65	lipoprotein(a)	Homo sapiens	13-18
8183947-2	1994	More recently it was found that the same membrane function can be inhibited by bacitracin, an inhibitor of protein disulfide-isomerase (PDI), and by monoclonal antibodies against PDI, suggesting that PDI catalyzes a thiol-disulfide interchange between its thiols and the disulfides of membrane-bound macromolecules.	Sulfhydryl Compounds	256-262	protein disulfide isomerase family A member 2	Homo sapiens	136-139
8183947-2	1994	More recently it was found that the same membrane function can be inhibited by bacitracin, an inhibitor of protein disulfide-isomerase (PDI), and by monoclonal antibodies against PDI, suggesting that PDI catalyzes a thiol-disulfide interchange between its thiols and the disulfides of membrane-bound macromolecules.	Sulfhydryl Compounds	256-262	protein disulfide isomerase family A member 2	Homo sapiens	179-182
8183947-2	1994	More recently it was found that the same membrane function can be inhibited by bacitracin, an inhibitor of protein disulfide-isomerase (PDI), and by monoclonal antibodies against PDI, suggesting that PDI catalyzes a thiol-disulfide interchange between its thiols and the disulfides of membrane-bound macromolecules.	Sulfhydryl Compounds	256-262	protein disulfide isomerase family A member 2	Homo sapiens	179-182
8183947-4	1994	The results imply that HIV and its target cell engage in a thiol-disulfide interchange mediated by PDI and that the reduction of critical disulfides in viral envelope glycoproteins may be the initial event that triggers conformational changes required for HIV entry and cell infection.	Sulfhydryl Compounds	59-64	protein disulfide isomerase family A member 2	Homo sapiens	99-102
7513556-7	1994	Thiol-disulfide exchange is normally very slow at acidic pH but occurs rapidly with DsbA; consequently, DsbA catalyzed the disulfide folding of BPTI under acidic conditions.	Sulfhydryl Compounds	0-5	spleen trypsin inhibitor I	Bos taurus	144-148
8200081-6	1994	Concordantly, ODC induction by BHTOOH could be completely inhibited by soluble thiol compounds.	Sulfhydryl Compounds	79-84	ornithine decarboxylase 1	Homo sapiens	14-17
8200081-7	1994	These results suggest that ODC induction is mediated by a thiol-reactive metabolite of BHTOOH.	Sulfhydryl Compounds	58-63	ornithine decarboxylase 1	Homo sapiens	27-30
8163576-7	1994	Heavy metal ions and thiol reagents were also highly potent inducers of HO-1 in human RPE cells.	Sulfhydryl Compounds	21-26	heme oxygenase 1	Homo sapiens	72-76
8071611-13	1994	Similarly, thiol production was increased 29% by IFN-gamma pretreatment.	Sulfhydryl Compounds	11-16	interferon gamma	Mus musculus	49-58
8042190-2	1994	In this study we present evidence indicating that after treatment of Lp(a) with sulfhydryl compounds, immunoreactivity is changed, structural changes occur and functional characteristics regarding the numerous kringle structures in apo(a) disappear.	Sulfhydryl Compounds	80-100	lipoprotein(a)	Homo sapiens	69-74
8042190-3	1994	Purified Lp(a) was subjected to variable concentrations (0.01-10 mM) of various sulfhydryl compounds: DTT, 2-mercapto-ethanol (BME), N-acetylcysteine (NAC) and homocysteine (HCys).	Sulfhydryl Compounds	80-100	lipoprotein(a)	Homo sapiens	9-14
8042190-12	1994	The observed immunological and functional changes of Lp(a) indicate that apo(a) kringle function is severely affected by sulfhydryl compounds.	Sulfhydryl Compounds	121-141	lipoprotein(a)	Homo sapiens	53-58
7909847-0	1994	Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors.	Sulfhydryl Compounds	75-80	glutamyl aminopeptidase	Homo sapiens	36-52
7935607-1	1994	Trypanothione reductase (TR) is an NADPH-dependent flavoprotein oxidoreductase central to thiol metabolism in the trypanosomatids.	Sulfhydryl Compounds	90-95	trypanothione reductase	Leishmania donovani	0-23
8144645-6	1994	For all cell lines studied, secreted hCG-beta migrated as monomeric beta during reducing SDS-polyacrylamide gel electrophoresis, indicating that hCG-beta multimers formed via intermolecular cross-linking of unpaired thiols.	Sulfhydryl Compounds	216-222	chorionic gonadotropin subunit beta 3	Homo sapiens	37-45
8089078-10	1994	SP-22 was also homologous to the C22 component of alkyl hydroperoxide reductase in Salmonella typhimurium, thiol-specific antioxidant in Saccharomyces cerevisiae, and some other proteins.	Sulfhydryl Compounds	107-112	peroxiredoxin 3	Mus musculus	0-5
8179594-4	1994	To investigate the role of reactive oxygen species we studied the effects of alpha-lipoic acid and dihydrolipoic acid (natural thiol antioxidants) on the expression of c-fos mRNA in human Jurkat T cells.	Sulfhydryl Compounds	127-132	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	168-173
8163468-2	1994	To better understand the thiol chemistry of the mammalian thioredoxin-thioredoxin reductase redox system, mutants of human thioredoxin were produced by site-directed mutagenesis in which the two active site cysteines were replaced by serine residues, individually (C32S and C35S) and in combination (C32S/C35S).	Sulfhydryl Compounds	25-30	thioredoxin	Homo sapiens	58-69
7925685-4	1994	Thus the rate and the maximal extent of ALR2 inactivation are proportional to the redox ratio of the thiol used as modifying agent (i.e. [GSH]/[GSSG]).	Sulfhydryl Compounds	101-106	lens aldose reductase pseudogene	Bos taurus	40-44
7925685-8	1994	A reduced efficiency in the enzyme-cofactor binding following the GSSG dependent modification of ALR2, appears to be associated to the thiol accessibility of GS-ALR2 measured at different temperatures.	Sulfhydryl Compounds	135-140	lens aldose reductase pseudogene	Bos taurus	97-101
7935607-1	1994	Trypanothione reductase (TR) is an NADPH-dependent flavoprotein oxidoreductase central to thiol metabolism in the trypanosomatids.	Sulfhydryl Compounds	90-95	trypanothione reductase	Leishmania donovani	25-27
8142488-5	1994	The activity recovery is therefore due to the regeneration of reactive thiol and it appears that the active-site thiols are essential for the activity of rabbit muscle creatine kinase.	Sulfhydryl Compounds	71-76	creatine kinase M-type	Oryctolagus cuniculus	161-183
8144038-1	1994	The complete cDNA encoding human thiol-specific antioxidant protein (PRP) was isolated from a human brain cDNA library in the lambda Zap expression vector.	Sulfhydryl Compounds	33-38	prion protein	Homo sapiens	69-72
8144038-1	1994	The complete cDNA encoding human thiol-specific antioxidant protein (PRP) was isolated from a human brain cDNA library in the lambda Zap expression vector.	Sulfhydryl Compounds	33-38	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	133-136
8142488-5	1994	The activity recovery is therefore due to the regeneration of reactive thiol and it appears that the active-site thiols are essential for the activity of rabbit muscle creatine kinase.	Sulfhydryl Compounds	113-119	creatine kinase M-type	Oryctolagus cuniculus	161-183
8114670-3	1994	RyR agonists, micromolar Ca2+, and nanomolar ryanodine promote a slow SR thiol-CPM reaction, with an apparent rate constant k of 0.0021 +/- 0.0002 sec-1, and &gt; 89% of the fluorescence is associated with the 110-kDa Ca2+ pump, which constitutes 68% of the protein in the SR preparations.	Sulfhydryl Compounds	73-78	ryanodine receptor 1	Homo sapiens	0-3
8125943-5	1994	Calmodulin stimulation of the enzyme was restored by treatment with dithiothreitol or glutathione which reduce disulfides to free thiols.	Sulfhydryl Compounds	130-136	calmodulin 1	Homo sapiens	0-10
8125943-7	1994	We propose that the loss in calmodulin sensitivity caused by these reagents may be due to the oxidation one or more sets of vicinal thiols present in the enzyme.	Sulfhydryl Compounds	132-138	calmodulin 1	Homo sapiens	28-38
8125130-2	1994	In these adducts C3b was radioactively labeled in the free thiol group generated during activation of the internal thioester of C3.	Sulfhydryl Compounds	59-64	complement C3	Homo sapiens	17-20
8123012-1	1994	A thiol-specific antioxidant protein (Protector Protein, PRP) was purified from human red blood cells (RBC).	Sulfhydryl Compounds	2-7	prion protein	Homo sapiens	57-60
8123012-2	1994	The PRP exists as a predominant protein in human RBC, which showed distinct thiol-specific antioxidant activities in the presence of dithiothreitol (DTT) as a reducing equivalent.	Sulfhydryl Compounds	76-81	prion protein	Homo sapiens	4-7
8123012-3	1994	The human RBC PRP (HRPRP) completely inhibited visible absorption spectral changes of oxyhemoglobin, DNA cleavage, and the peroxidation of RBC membrane by a nonenzymatic Fe3+/O2/thiol mixed-function oxidation system capable of generating hydroxyl radical.	Sulfhydryl Compounds	178-183	prion protein	Homo sapiens	14-17
7509599-6	1994	Thiol redox reactions are known to play a role in regulating conformational changes in the insulin receptor and possibly also in the IGF-I receptor.	Sulfhydryl Compounds	0-5	insulin receptor	Homo sapiens	91-107
7509599-6	1994	Thiol redox reactions are known to play a role in regulating conformational changes in the insulin receptor and possibly also in the IGF-I receptor.	Sulfhydryl Compounds	0-5	insulin like growth factor 1 receptor	Homo sapiens	133-147
8312273-1	1994	A three-disulfide form of human alpha-lactalbumin, with free thiols on Cys6 and Cys120, can adopt the molten globule conformation.	Sulfhydryl Compounds	61-67	lactalbumin alpha	Homo sapiens	32-49
8071087-8	1994	The Km was 0.62 mM and the Vmax 3 mumol glucose-6-phosphate/cm3 wet tissue and per min at 25 degrees C. It is concluded that G6PD in oligodendrocytes may be important for the generation of NADPH required for lipid biosynthesis related to myelogenesis, and reduction of glutathione required for protection of membrane sulphydryl groups.	Sulfhydryl Compounds	317-327	glucose-6-phosphate dehydrogenase	Rattus norvegicus	125-129
7507957-4	1994	Through the cross-linkage by thiol-reactive bivalent mercury, transmembrane CD4, CD3, and CD45 and glycosylphosphatidylinositol-anchored Thy-1 were aggregated together on thymocytes or T lymphocytes.	Sulfhydryl Compounds	29-34	CD4 antigen	Mus musculus	76-79
7507957-4	1994	Through the cross-linkage by thiol-reactive bivalent mercury, transmembrane CD4, CD3, and CD45 and glycosylphosphatidylinositol-anchored Thy-1 were aggregated together on thymocytes or T lymphocytes.	Sulfhydryl Compounds	29-34	CD3 antigen, epsilon polypeptide	Mus musculus	81-84
7507957-4	1994	Through the cross-linkage by thiol-reactive bivalent mercury, transmembrane CD4, CD3, and CD45 and glycosylphosphatidylinositol-anchored Thy-1 were aggregated together on thymocytes or T lymphocytes.	Sulfhydryl Compounds	29-34	protein tyrosine phosphatase, receptor type, C	Mus musculus	90-94
8174845-0	1994	Effect on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group: bradykinin may improve insulin resistance in dogs and humans.	Sulfhydryl Compounds	92-102	kininogen 1	Canis lupus familiaris	110-120
8078516-5	1994	The protein disulfide isomerase of schistosomes, produced in an expression vector in Escherichia coli, catalyzes disulfide/sulfhydryl isomerization in vitro.	Sulfhydryl Compounds	123-133	protein-disulfide isomerase	Escherichia coli	4-31
8090079-5	1994	The alpha 1-AT preparation selectively inhibited thiol-activated bacterial toxins; it was inactive against snake venom hemolysins, mastoparan, and oxygen-stable bacterial toxins.	Sulfhydryl Compounds	49-54	serpin family A member 1	Homo sapiens	4-14
8119911-1	1994	Implications of photocross-linking of troponin I to troponin C thiol mutants.	Sulfhydryl Compounds	63-68	tenascin	Oryctolagus cuniculus	52-62
8114670-5	1994	Nonreducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis of CPM-labeled SR protein and Western blot analyses with antiryanodine or antitriadin antibodies reveal that the hyperreactive thiols labeled by CPM under conditions favoring channel closure are localized principally to the RyR protomer and triadin, which constitute &lt; 6% of the protein in the SR preparation.	Sulfhydryl Compounds	197-203	RNA binding protein with serine rich domain 1	Homo sapiens	85-95
8114670-5	1994	Nonreducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis of CPM-labeled SR protein and Western blot analyses with antiryanodine or antitriadin antibodies reveal that the hyperreactive thiols labeled by CPM under conditions favoring channel closure are localized principally to the RyR protomer and triadin, which constitute &lt; 6% of the protein in the SR preparation.	Sulfhydryl Compounds	197-203	ryanodine receptor 1	Homo sapiens	294-297
8114670-6	1994	Immunoprecipitation experiments with antiryanodine and antitriadin monoclonal antibodies confirm the location of CPM-labeled thiol groups on RyR and triadin, respectively.	Sulfhydryl Compounds	125-130	ryanodine receptor 1	Homo sapiens	141-144
8114670-8	1994	It is shown that either 1) the redox state (sulfhydryl/disulfide status) or 2) the accessibility of the hyperreactive thiols on the RyR and triadin is determined by the conformational state of the channel.	Sulfhydryl Compounds	44-54	ryanodine receptor 1	Homo sapiens	132-135
8114670-8	1994	It is shown that either 1) the redox state (sulfhydryl/disulfide status) or 2) the accessibility of the hyperreactive thiols on the RyR and triadin is determined by the conformational state of the channel.	Sulfhydryl Compounds	118-124	ryanodine receptor 1	Homo sapiens	132-135
8114670-10	1994	1,4-Naphthoquinone (0.4-40 pmol/micrograms of protein) selectively oxidizes hyperreactive thiols on RyR and triadin and releases Ca2+ from SR vesicles, without inhibiting Ca(2+)-ATPase activity.	Sulfhydryl Compounds	90-96	ryanodine receptor 1	Homo sapiens	100-103
8003969-7	1994	But reduced P44 with 4 thiol groups did unfold.	Sulfhydryl Compounds	23-28	interferon induced protein 44	Homo sapiens	12-15
8297391-4	1994	The determination of its molecular mass (about 70 kDa) and its pH range for optimum activity (neutral pH) as well as the results obtained with various inhibitors indicate that this [3H]Val-Leu-Met releasing enzyme resembles endopeptidase 24.15: a thiol-dependent zinc metallopeptidase.	Sulfhydryl Compounds	247-252	thimet oligopeptidase 1	Sus scrofa	224-243
8116876-4	1994	As an example of this approach, an FAB" fragment of a mouse monoclonal antibody (anti-human growth hormone) was labeled with tetramethylrhodamine-iodoacetamide at a hinge region thiol group.	Sulfhydryl Compounds	178-183	FA complementation group B	Homo sapiens	35-38
8116876-4	1994	As an example of this approach, an FAB" fragment of a mouse monoclonal antibody (anti-human growth hormone) was labeled with tetramethylrhodamine-iodoacetamide at a hinge region thiol group.	Sulfhydryl Compounds	178-183	growth hormone 1	Homo sapiens	92-106
8187250-4	1994	Using high-performance liquid chromatographic techniques, we have identified sulfhydryl and disulfide groups of apoB-100 from LDL.	Sulfhydryl Compounds	77-87	apolipoprotein B	Homo sapiens	112-120
8311458-0	1994	S-thiolation and irreversible oxidation of sulfhydryls on carbonic anhydrase III during oxidative stress: a method for studying protein modification in intact cells and tissues.	Sulfhydryl Compounds	43-54	carbonic anhydrase 3	Rattus norvegicus	58-80
7736516-5	1994	Maleimide-substituted COL-1 anti-CEA monoclonal antibody was linked to free thiol groups of beta-D-galactosidase.	Sulfhydryl Compounds	76-81	carcinoembryonic antigen gene family	Mus musculus	33-36
8304510-3	1994	The sulfhydryl compounds captopril and N-(2-mercaptopropionyl)-glycine (MPG) are antioxidant compounds that previously have been shown to protect the myocardium from ischemia and reperfusion-induced damage.	Sulfhydryl Compounds	4-24	DNA-3-methyladenine glycosylase	Oryctolagus cuniculus	72-75
8309349-2	1994	On the basis of its mechanism of inhibition, it has been suggested that MR889, upon reaction with elastase, would generate new free thiol groups.	Sulfhydryl Compounds	132-137	elastase, neutrophil expressed	Homo sapiens	98-106
8151605-3	1994	(1) The levels of plasma thiol and plasma glutathione in PIH women with proteinuria were markedly lower than that in the normal pregnancy.	Sulfhydryl Compounds	25-30	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	57-60
8299312-1	1994	BACKGROUND: Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including 6-mercaptopurine.	Sulfhydryl Compounds	149-169	thiopurine S-methyltransferase	Homo sapiens	12-40
8299312-1	1994	BACKGROUND: Thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds, including 6-mercaptopurine.	Sulfhydryl Compounds	149-169	thiopurine S-methyltransferase	Homo sapiens	42-46
7903528-2	1993	The understanding of the unique specificity of endo-oligopeptidase A was useful for the synthesis of affinity labeling compounds containing as a thiol reactive group the Cys-(3-nitro-2-pyridinesulfenyl) group into dynorphin-derived peptides which are among the best substrates and competitive inhibitor of endopeptidase 22.19.	Sulfhydryl Compounds	145-150	nudE neurodevelopment protein 1 like 1	Homo sapiens	47-68
8140052-4	1994	The covalent process has been elucidated to be intermolecular thiol-catalyzed disulfide interchange following beta-elimination of an intact disulfide bridge in the insulin molecule.	Sulfhydryl Compounds	62-67	insulin	Homo sapiens	164-171
8115354-1	1994	The angiotensin converting enzyme (ACE) inhibitor captopril, a free-thiol compound used widely as an antihypertensive agent, also inhibits radiation-induced pulmonary fibrosis in rats (Ward et al., Int J Radiat Oncol Biol Phys 19:1405, 1990).	Sulfhydryl Compounds	68-73	angiotensin I converting enzyme	Rattus norvegicus	4-33
8115354-1	1994	The angiotensin converting enzyme (ACE) inhibitor captopril, a free-thiol compound used widely as an antihypertensive agent, also inhibits radiation-induced pulmonary fibrosis in rats (Ward et al., Int J Radiat Oncol Biol Phys 19:1405, 1990).	Sulfhydryl Compounds	68-73	angiotensin I converting enzyme	Rattus norvegicus	35-38
7903255-5	1993	The involvement of Cys side chains in the reaction with oATP was confirmed by using Nbs2 (5,5"-dithiobis(2-nitrobenzoate)) to estimate thiol groups in both modified and unmodified GroEL.	Sulfhydryl Compounds	135-140	GroEL	Escherichia coli	180-185
7903528-1	1993	Brain endo-oligopeptidase A, a neuropeptide-metabolizing endopeptidase, has been considered a cysteine-endopeptidase because it is activated by thiols and inhibited by phydroxymercuribenzoate or 5,5"-dithiobis-(2-nitrobenzoic acid).	Sulfhydryl Compounds	144-150	nudE neurodevelopment protein 1 like 1	Homo sapiens	6-27
8138187-1	1993	In the present study, using the technique of EPR spin trapping with DMPO a spin trap, we demonstrated formation of thiyl radicals from thiol-containing angiotensin converting enzyme (ACE) inhibitor captopril (CAP) and from its stereoisomer epicaptopril (EPICAP), a non-ACE inhibitor, in the process of .OH radical scavenging.	Sulfhydryl Compounds	135-140	angiotensin I converting enzyme	Homo sapiens	183-186
8177227-1	1993	The activity lost during storage of a solution of muscle glyceraldehyde 3-phosphate dehydrogenase was rapidly restored on adding a thiol compound, but not arsenite or azide.	Sulfhydryl Compounds	131-136	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	57-97
8138187-1	1993	In the present study, using the technique of EPR spin trapping with DMPO a spin trap, we demonstrated formation of thiyl radicals from thiol-containing angiotensin converting enzyme (ACE) inhibitor captopril (CAP) and from its stereoisomer epicaptopril (EPICAP), a non-ACE inhibitor, in the process of .OH radical scavenging.	Sulfhydryl Compounds	135-140	angiotensin I converting enzyme	Homo sapiens	152-181
8280053-1	1993	(R)-3-Hydroxybutyrate dehydrogenase (BDH) is a phosphatidylcholine-requiring tetrameric enzyme with two thiol groups (SH-1 and SH-2) per protomer.	Sulfhydryl Compounds	104-109	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	37-40
8138187-1	1993	In the present study, using the technique of EPR spin trapping with DMPO a spin trap, we demonstrated formation of thiyl radicals from thiol-containing angiotensin converting enzyme (ACE) inhibitor captopril (CAP) and from its stereoisomer epicaptopril (EPICAP), a non-ACE inhibitor, in the process of .OH radical scavenging.	Sulfhydryl Compounds	135-140	angiotensin I converting enzyme	Homo sapiens	269-272
8301226-5	1993	Thiol- and Cu(2+)-modified LDL underwent lipid peroxidation and exhibited a number of properties of cell-modified LDL, including increased mobility on agarose gel electrophoresis and fragmentation of apolipoprotein B-100.	Sulfhydryl Compounds	0-5	apolipoprotein B	Homo sapiens	200-220
8258344-0	1993	Chemical reactivity of an HLA-B27 thiol group.	Sulfhydryl Compounds	34-39	melanocortin 2 receptor accessory protein	Homo sapiens	30-33
8258344-1	1993	Techniques have been developed to measure the reactivity of free thiols in the HLA class I antigen-binding cleft.	Sulfhydryl Compounds	65-71	MHC class I polypeptide-related sequence A	Homo sapiens	79-98
8258344-2	1993	HLA-B27, which sequencing predicts has a free cysteine at position 67, reacts rapidly with the positively charged thiol reagent monobromotrimethyl-ammoniobimane bromide (qBBr) to give products which are identifiable by isoelectric focusing.	Sulfhydryl Compounds	114-119	major histocompatibility complex, class I, B	Homo sapiens	0-7
8258344-6	1993	Two human cell lines which are known to carry identical B27 genes but do not present the same peptides, differ considerably in the accessibility of their B27 thiol.	Sulfhydryl Compounds	158-163	melanocortin 2 receptor accessory protein	Homo sapiens	154-157
8258344-7	1993	Evidence from mouse cells transfected with mutant B27 genes suggests that a unique lysine at position 70 in the wild-type molecule increases reactivity to thiol-reactive metabolites.	Sulfhydryl Compounds	155-160	melanocortin 2 receptor accessory protein	Homo sapiens	50-53
8312225-5	1993	By blocking thiol and serine proteases with specific inhibitors or by raising the intracellular pH with chloroquine during BI pulse, the presentation capacity of IFN-gamma-activated BMMph was significantly enhanced, while the presentation function of GM-CSF-pulsed macrophages was not positively influenced.	Sulfhydryl Compounds	12-17	interferon gamma	Bos taurus	162-171
8312225-5	1993	By blocking thiol and serine proteases with specific inhibitors or by raising the intracellular pH with chloroquine during BI pulse, the presentation capacity of IFN-gamma-activated BMMph was significantly enhanced, while the presentation function of GM-CSF-pulsed macrophages was not positively influenced.	Sulfhydryl Compounds	12-17	colony stimulating factor 2	Bos taurus	251-257
8226953-2	1993	In this study, the effects of the sulfhydryl reagent thimerosal were investigated on Ca2+ mobilization and on InsP3 binding.	Sulfhydryl Compounds	34-44	carbonic anhydrase 2	Bos taurus	85-88
8228244-0	1993	Requirement of thiol compounds as reducing agents for IL-2-mediated induction of LAK activity and proliferation of human NK cells.	Sulfhydryl Compounds	15-20	interleukin 2	Homo sapiens	54-58
8265181-7	1993	Thiol analysis gave evidence of a possible difference in polymerization between the three mucins, in that thin (the smallest mucin) contained the lowest number of thiols.	Sulfhydryl Compounds	0-5	LOC100508689	Homo sapiens	90-95
7693706-10	1993	After incubation with urea at 25 degrees C, native vitronectin, treated during purification with dithionitrobenzoic acid to force free sulfhydryls to intramolecular disulfides, exhibited increased reactivity with antibody 8E6, increased binding to heparin, and oligomerization.	Sulfhydryl Compounds	135-146	vitronectin	Homo sapiens	51-62
8241252-15	1993	These results may be interpreted to suggest that inhibition of the Ca-pump ATPase in intact RBCs occurs as a result of tBHP-induced oxidant stress and subsequent lipid peroxidation which can be prevented by certain antioxidants including butylated hydroxytoluene, stobadine, and thiol-containing compounds such as dithiothreitol.	Sulfhydryl Compounds	279-284	dynein axonemal heavy chain 8	Homo sapiens	75-81
8228244-7	1993	The results suggest that (1) L-cystine or thiol containing compounds such as L-cysteine, 2-ME, or GSH are necessary for effective IL-2-activation of human NK cells, (2) these compounds must be functional proton-donors, i.e., reducing agents, implying regulation of the IL-2 activation pathway by oxidation-reduction, and (3) GSH synthesis is necessary for the activation.	Sulfhydryl Compounds	42-47	interleukin 2	Homo sapiens	130-134
8254340-0	1993	Reversal of copper(II)-induced methemoglobin formation by thiols.	Sulfhydryl Compounds	58-64	hemoglobin subunit gamma 2	Homo sapiens	31-44
8254340-3	1993	In the present studies, when oxyhemoglobin was first oxidized to methemoglobin by Cu(II) and thiols such as glutathione added to the sample, methemoglobin was reduced to oxyhemoglobin.	Sulfhydryl Compounds	93-99	hemoglobin subunit gamma 2	Homo sapiens	65-78
8254340-3	1993	In the present studies, when oxyhemoglobin was first oxidized to methemoglobin by Cu(II) and thiols such as glutathione added to the sample, methemoglobin was reduced to oxyhemoglobin.	Sulfhydryl Compounds	93-99	hemoglobin subunit gamma 2	Homo sapiens	141-154
8243474-4	1993	Following treatment of L. donovani cells with the thiol-oxidizing agent diamide, the ability to regenerate dihydrotrypanothione from trypanothione disulphide was considerably enhanced in cells which over-expressed trypanothione reductase.	Sulfhydryl Compounds	50-55	trypanothione reductase	Leishmania donovani	214-237
8238538-4	1993	NAC treatment also increased blood acid soluble sulfhydryl levels, reduced lung GSSG increases, and decreased breath H2O2 levels in rats given IL-1 intratracheally.	Sulfhydryl Compounds	48-58	X-linked Kx blood group	Homo sapiens	0-3
8254340-4	1993	Once reduction of methemoglobin stopped, as the thiol was oxidized, the oxyhemoglobin formed was reoxidized by Cu(II).	Sulfhydryl Compounds	48-53	hemoglobin subunit gamma 2	Homo sapiens	18-31
8254340-5	1993	The addition of the same thiols to methemoglobin formed by autoxidation did not reduce it to oxyhemoglobin.	Sulfhydryl Compounds	25-31	hemoglobin subunit gamma 2	Homo sapiens	35-48
8254340-6	1993	The addition of thiols such as cysteine, which are rapidly oxidized by Cu(II), to methemoglobin formed by incubation with Cu(II) also resulted in reduction of methemoglobin, but the period of reversal was much shorter than that seen with glutathione and other less reactive thiols.	Sulfhydryl Compounds	16-22	hemoglobin subunit gamma 2	Homo sapiens	82-95
8254340-6	1993	The addition of thiols such as cysteine, which are rapidly oxidized by Cu(II), to methemoglobin formed by incubation with Cu(II) also resulted in reduction of methemoglobin, but the period of reversal was much shorter than that seen with glutathione and other less reactive thiols.	Sulfhydryl Compounds	16-22	hemoglobin subunit gamma 2	Homo sapiens	159-172
8254340-6	1993	The addition of thiols such as cysteine, which are rapidly oxidized by Cu(II), to methemoglobin formed by incubation with Cu(II) also resulted in reduction of methemoglobin, but the period of reversal was much shorter than that seen with glutathione and other less reactive thiols.	Sulfhydryl Compounds	274-280	hemoglobin subunit gamma 2	Homo sapiens	82-95
8254340-9	1993	When both glutathione and EDTA were added to this system, the response was the same as with EDTA alone, suggesting that Cu(I) or (II) may be required for the reduction of copper-induced methemoglobin by thiols.	Sulfhydryl Compounds	203-209	hemoglobin subunit gamma 2	Homo sapiens	186-199
8254340-10	1993	These studies show that thiols that are slowly oxidized by Cu(II) both protect oxyhemoglobin from Cu(II)-induced oxidation, and reduce the methemoglobin formed to oxyhemoglobin.	Sulfhydryl Compounds	24-30	hemoglobin subunit gamma 2	Homo sapiens	139-152
8131967-0	1993	The effects of thiol modifiers on the activation of NF kappa B by interleukin-1.	Sulfhydryl Compounds	15-20	nuclear factor kappa B subunit 1	Homo sapiens	52-62
8256869-1	1993	Methodology is described for characterization of the kinetics and equilibria of thiol/disulfide interchange reactions of the disulfide bonds in the neurohypophyseal peptide hormones arginine vasopressin and oxytocin and the related peptides pressinoic acid and tocinoic acid.	Sulfhydryl Compounds	80-85	arginine vasopressin	Homo sapiens	191-202
8256869-6	1993	To illustrate application of the methodology, rate and equilibrium constants are reported for the thiol/disulfide interchange reactions of cysteine with arginine vasopressin at pH 7.0.	Sulfhydryl Compounds	98-103	arginine vasopressin	Homo sapiens	162-173
8131967-0	1993	The effects of thiol modifiers on the activation of NF kappa B by interleukin-1.	Sulfhydryl Compounds	15-20	interleukin 1 alpha	Homo sapiens	66-79
8404659-7	1993	In Western blots of 293 cells transfected with the FSH receptor, AntiF reveals the recombinant receptor as a heterogenous glycoprotein with a molecular mass of 58,000-83,000 daltons (in the absence of thiol-reducing agents) or 69,000-81,000 (in the presence of thiol reducing agents).	Sulfhydryl Compounds	261-266	follicle stimulating hormone receptor	Homo sapiens	51-63
8305515-3	1993	The synthesis of mAb-SEA conjugates which were prepared by introducing thiol groups on SEA and iodoacetyl or maleimide groups on mAb forming a stable thioether linkage between SEA and mAb is described.	Sulfhydryl Compounds	71-76	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	21-24
8376766-1	1993	Guanine ribonucleosides that have been substituted at the C8 position with bromine or thiol groups have been shown previously to activate NK cells and to act as sparing agents for IL-2 in the generation of LAK cells.	Sulfhydryl Compounds	86-91	interleukin 2	Homo sapiens	180-184
8275097-2	1993	The gene, cys1, encoding this enzyme was isolated from a wheat (Triticum aestivum L.) cDNA library, and its deduced amino acid sequence found to show 53% sequence identity with the O-acetyl-serine (thiol) lyase of Escherichia coli and Salmonella typhimurium.	Sulfhydryl Compounds	198-203	cysteine synthase	Triticum aestivum	10-14
8376387-7	1993	Recombinant SPC3 was inhibited most effectively by the thiol-reactive reagent p-hydroxymecuribenzoate and the heavy metal chelators EDTA and EGTA.	Sulfhydryl Compounds	55-60	proprotein convertase subtilisin/kexin type 1	Homo sapiens	12-16
8107017-5	1993	The suppressive effect of 250-500 mmol HNE l-1 on the motility of reactivated ram sperm models (P &lt; 0.05) was prevented by the addition of 1 mmol reduced glutathione l-1 to the reactivation medium, suggesting that HNE inhibits ram sperm motility via oxidation of sulfhydryl groups in the axoneme.	Sulfhydryl Compounds	266-276	elastase, neutrophil expressed	Homo sapiens	39-42
8411164-1	1993	Periplasmic protein disulfide isomerase (DsbA) from Escherichia coli is a strongly oxidizing thiol reagent with one catalytic disulfide bridge and an intrinsic redox potential of -0.089 V. Gel filtration experiments and analytical ultracentrifugation studies demonstrate that DsbA is a monomeric protein with a molecular mass of 21.1 kDa, independent of its redox state.	Sulfhydryl Compounds	93-98	protein-disulfide isomerase	Escherichia coli	12-39
8295845-7	1993	It is argued that SAM treatment causes a surplus of thiols that allows the full expression of ALA-D catalytic activity.	Sulfhydryl Compounds	52-58	aminolevulinate dehydratase	Rattus norvegicus	94-99
8373360-4	1993	Thus human thimet oligopeptidase also is a thiol-dependent metallo-oligopeptidase with M(r) about 75,000.	Sulfhydryl Compounds	43-48	thimet oligopeptidase 1	Homo sapiens	11-32
8364016-8	1993	These results indicate that an atherogenic amino acid, homocysteine, can initiate coagulation by the TF pathway through a mechanism involving the free thiol group of the amino acid and by TF gene transcription.	Sulfhydryl Compounds	151-156	coagulation factor III, tissue factor	Homo sapiens	101-103
8274513-1	1993	Monomethoxypolyethylene glycol (mPEG) of average molecular weight 5000 was transformed in a series of synthetic steps to a new activated form of PEG, a stable thiol-protected intermediary, for reaction with cysteine residues in proteins under mild conditions to produce PEG--protein conjugates as possible candidates for therapeutics.	Sulfhydryl Compounds	159-164	progestagen associated endometrial protein	Homo sapiens	33-36
8274513-1	1993	Monomethoxypolyethylene glycol (mPEG) of average molecular weight 5000 was transformed in a series of synthetic steps to a new activated form of PEG, a stable thiol-protected intermediary, for reaction with cysteine residues in proteins under mild conditions to produce PEG--protein conjugates as possible candidates for therapeutics.	Sulfhydryl Compounds	159-164	progestagen associated endometrial protein	Homo sapiens	145-148
8395501-0	1993	Direct identification of the primary nucleophile of thioredoxin f. Thioredoxin, by virtue of the proximal active-site sulfhydryls (Trp-Cys-Gly-Pro-Cys), catalyzes thiol-disulfide exchange with specific target enzymes.	Sulfhydryl Compounds	118-129	thioredoxin	Homo sapiens	52-63
8395501-0	1993	Direct identification of the primary nucleophile of thioredoxin f. Thioredoxin, by virtue of the proximal active-site sulfhydryls (Trp-Cys-Gly-Pro-Cys), catalyzes thiol-disulfide exchange with specific target enzymes.	Sulfhydryl Compounds	118-129	thioredoxin	Homo sapiens	67-78
8395501-0	1993	Direct identification of the primary nucleophile of thioredoxin f. Thioredoxin, by virtue of the proximal active-site sulfhydryls (Trp-Cys-Gly-Pro-Cys), catalyzes thiol-disulfide exchange with specific target enzymes.	Sulfhydryl Compounds	163-168	thioredoxin	Homo sapiens	52-63
8395501-0	1993	Direct identification of the primary nucleophile of thioredoxin f. Thioredoxin, by virtue of the proximal active-site sulfhydryls (Trp-Cys-Gly-Pro-Cys), catalyzes thiol-disulfide exchange with specific target enzymes.	Sulfhydryl Compounds	163-168	thioredoxin	Homo sapiens	67-78
8260946-1	1993	Human corneal aldehyde dehydrogenase (designated ALDH3) was purified to homogeneity and characterised with respect to substrate specificity and inhibition by thiol reagents.	Sulfhydryl Compounds	158-163	aldehyde dehydrogenase 3 family member A1	Homo sapiens	49-54
8360774-1	1993	To examine the modification of reactive sulfhydryls of carbonic anhydrase III (CA III), hepatocytes were prepared by collagenase perfusion from Se deficient and Se-adequate male Sprague-Dawley rats.	Sulfhydryl Compounds	40-51	carbonic anhydrase 3	Rattus norvegicus	55-77
8370158-14	1993	The anti-tumour effect of haemin and IL-2 was enhanced (63% decrease in metastases) by administration of the thiol compound, N-acetylcysteine.	Sulfhydryl Compounds	109-114	interleukin 2	Mus musculus	37-41
8349617-8	1993	Conformational activation of latent SL-2 precursor by SDS gave rise to a full-length, uncleaved (M(r) 54,000) active form and at the same time exposed a cryptic thiol group.	Sulfhydryl Compounds	161-166	matrix metallopeptidase 10	Homo sapiens	36-40
9831477-1	1993	In the presence of amine-containing sulfhydryl compounds, binding of heat-transformed cytosolic rat liver glucocorticoid receptor complex (GRC) to double-stranded calf thymus DNA-coated cellulose and to rat liver chromatin was enhanced up to 10-fold.	Sulfhydryl Compounds	36-46	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	106-129
7688390-0	1993	Anti-TAPA-1 antibodies induce protein tyrosine phosphorylation that is prevented by increasing intracellular thiol levels.	Sulfhydryl Compounds	109-114	CD81 molecule	Homo sapiens	5-11
7688390-9	1993	These experiments demonstrate that tyrosine kinases are involved in propagating the antiproliferative signal initiated by the anti-TAPA-1 antibody and suggest that this signal is dependent upon the level of intracellular thiols.	Sulfhydryl Compounds	221-227	CD81 molecule	Homo sapiens	131-137
18613043-6	1993	Absence of free thiols indicated that the two Cys residues of CBD(Cex) form a disulfide bridge.	Sulfhydryl Compounds	16-22	cloacin lysis protein	Escherichia coli	66-69
8343528-6	1993	Gold thiols and zinc complexes inhibited heme oxidation by competing with the Cu(II)(His)2 for the beta-Cys-93 site.	Sulfhydryl Compounds	5-11	histatin 3	Homo sapiens	78-90
8393866-1	1993	Thiol reagents have been shown to increase cytosolic Ca2+ in several cell types.	Sulfhydryl Compounds	0-5	carbonic anhydrase 2	Homo sapiens	53-56
8393866-12	1993	At a resting concentration of 100-200 nM, Ca2+ has two effects: it increases the affinity of the active state of the receptor as thiol reagents do and transforms part of the receptors into the inactive high-affinity state.	Sulfhydryl Compounds	129-134	carbonic anhydrase 2	Homo sapiens	42-45
8217492-0	1993	High reactivity of [11C]CH3I with thiol group in the synthesis of C-11 labeled radiopharmaceuticals.	Sulfhydryl Compounds	34-39	RNA polymerase III subunit K	Homo sapiens	66-70
8352754-4	1993	Purified mucin, obtained from the void volume of the Sepharose column, was characterized by SDS/PAGE, amino acid and carbohydrate analyses, sensitivity to thiol reduction, and cross-reactivity with antibody preparations to rat and human intestinal mucins on Western blots.	Sulfhydryl Compounds	155-160	solute carrier family 13 member 2	Rattus norvegicus	9-14
8258460-2	1993	Here we show data demonstrating that a thiol group-reactive protein tyrosine phosphatase (PTP) inhibitor, phenylarsine oxide (PAO), uncouples a crucial part of the signaling events induced by anti-IgM or anti-Leu-4 (CD3) in human tonsil B lymphocytes, BL41 and Daudi B cell lines and Jurkat T lymphoma cells.	Sulfhydryl Compounds	39-44	protein tyrosine phosphatase receptor type U	Homo sapiens	90-93
8262302-13	1993	The levels of plasma thiol, superoxide dismutase and glutathione were significantly decreased in PIH women compared with normotensive pregnant women.	Sulfhydryl Compounds	21-26	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	97-100
8394700-4	1993	Treatment of xanthine dehydrogenase with the thiol reagent iodoacetamide significantly diminishes the ability of the enzyme to stabilize the neutral flavin semiquinone at high pH.	Sulfhydryl Compounds	45-50	xanthine dehydrogenase	Gallus gallus	13-35
8354272-7	1993	267, 4296-4299] have recently shown that the glutathione (GSH) thiol is deprotonated when it is in complex with glutathione S-transferase.	Sulfhydryl Compounds	63-68	glutathione S-transferase kappa 1	Homo sapiens	112-137
8391481-0	1993	Functions of interleukin-8 are mediated through thiol group(s) of IL-8 receptor in human polymorphonuclear neutrophils.	Sulfhydryl Compounds	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	13-26
8334132-1	1993	Chemical modification of rabbit muscle creatine kinase (CK) with thiol-specific reagents led to partial or complete inactivation of the enzyme.	Sulfhydryl Compounds	65-70	creatine kinase M-type	Oryctolagus cuniculus	32-54
8329391-6	1993	The results showed that PDI has a high redox potential and therefore is a good oxidant of nascent protein thiols.	Sulfhydryl Compounds	106-112	prolyl 4-hydroxylase subunit beta	Bos taurus	24-27
7687148-5	1993	Cyanylation of the thiol groups exposed upon methylamine treatment yields a derivative with the same hydrophobicity as native alpha 2M.	Sulfhydryl Compounds	19-24	alpha-2-macroglobulin	Homo sapiens	126-134
8391481-0	1993	Functions of interleukin-8 are mediated through thiol group(s) of IL-8 receptor in human polymorphonuclear neutrophils.	Sulfhydryl Compounds	48-53	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
8391481-5	1993	Treatment of neutrophils with 5,5"-dithio-bis(2-nitrobenzoic acid), a thiol-specific modifier, at the concentrations of 0.4 mM and 1 mM reduced IL-8 binding ability and IL-8-induced migration of the cells by 45% and 65%, respectively.	Sulfhydryl Compounds	70-75	C-X-C motif chemokine ligand 8	Homo sapiens	144-148
8391481-7	1993	All the evidence suggests that one or more critical thiol residues are located in the IL-8 binding site of the receptor which are indispensible for normal functions of IL-8.	Sulfhydryl Compounds	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
8391481-7	1993	All the evidence suggests that one or more critical thiol residues are located in the IL-8 binding site of the receptor which are indispensible for normal functions of IL-8.	Sulfhydryl Compounds	52-57	C-X-C motif chemokine ligand 8	Homo sapiens	168-172
8103788-9	1993	Finally, we designed an enzymatic system, based on glutathione reductase, that mimicked cellular thiol production.	Sulfhydryl Compounds	97-102	glutathione-disulfide reductase	Homo sapiens	51-72
8325319-0	1993	The efficient bovine insulin presentation capacity of bone marrow-derived macrophages activated by granulocyte-macrophage colony-stimulating factor correlates with a high level of intracellular reducing thiols.	Sulfhydryl Compounds	203-209	insulin	Bos taurus	21-28
8325319-0	1993	The efficient bovine insulin presentation capacity of bone marrow-derived macrophages activated by granulocyte-macrophage colony-stimulating factor correlates with a high level of intracellular reducing thiols.	Sulfhydryl Compounds	203-209	colony stimulating factor 2	Bos taurus	99-147
8325319-6	1993	Because processing of insulin depends on reduction of disulfide bonds, we analyzed the content of intracellular reducing thiols within IFN-gamma-M phi, GM-CSF-M phi, and untreated BMM phi.	Sulfhydryl Compounds	121-127	interferon gamma	Bos taurus	135-144
8325319-8	1993	These findings suggest that the lymphokines IFN-gamma and GM-CSF differently interfere with the processing capacity of BMM phi by differently regulating the intracellular concentration of the thiols reduced glutathione and cysteine.	Sulfhydryl Compounds	192-198	interferon gamma	Bos taurus	44-53
8325319-8	1993	These findings suggest that the lymphokines IFN-gamma and GM-CSF differently interfere with the processing capacity of BMM phi by differently regulating the intracellular concentration of the thiols reduced glutathione and cysteine.	Sulfhydryl Compounds	192-198	colony stimulating factor 2	Bos taurus	58-64
8325319-9	1993	A high level of these thiols induced by GM-CSF correlates with a prominent capacity to present the antigen bovine insulin.	Sulfhydryl Compounds	22-28	colony stimulating factor 2	Bos taurus	40-46
8323302-0	1993	Thiol-modulating agents increase manganese superoxide dismutase activity in human lung fibroblasts.	Sulfhydryl Compounds	0-5	superoxide dismutase 2	Homo sapiens	33-63
8325319-9	1993	A high level of these thiols induced by GM-CSF correlates with a prominent capacity to present the antigen bovine insulin.	Sulfhydryl Compounds	22-28	insulin	Bos taurus	114-121
8327504-4	1993	Exposure of GAPDH modified by NAD in the presence of SNP to HgCl2, which acts at thiol linkages, released two products.	Sulfhydryl Compounds	81-86	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	12-17
8392551-4	1993	Thiol methyltransferase (TMT) is a microsomal enzyme that preferentially catalyzes, the S-methylation of alipathic sulfhydryl compounds, whereas thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds.	Sulfhydryl Compounds	115-135	thiopurine S-methyltransferase	Homo sapiens	145-173
8392551-4	1993	Thiol methyltransferase (TMT) is a microsomal enzyme that preferentially catalyzes, the S-methylation of alipathic sulfhydryl compounds, whereas thiopurine methyltransferase (TPMT) is a cytoplasmic enzyme that preferentially catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds.	Sulfhydryl Compounds	115-135	thiopurine S-methyltransferase	Homo sapiens	175-179
8393194-1	1993	The free radical scavenging effects of an angiotensin-converting enzyme (ACE) inhibitor containing sulfhydryl (SH; captopril) were compared with those of ACE inhibitors not containing SH (enalapril, enalaprilat, delapril and its de-esterified products).	Sulfhydryl Compounds	99-109	angiotensin I converting enzyme	Homo sapiens	73-76
8327504-9	1993	These results demonstrate that NO-stimulated modification of GAPDH with NAD is not ADP-ribosylation as previously reported but rather is covalent binding of NAD through a NO-dependent thiol intermediate, possibly providing an example of an unexpected, altered reactivity of a nitrosylated protein.	Sulfhydryl Compounds	184-189	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	61-66
8391797-3	1993	These reagents were shown to be covalently bound to reductase SH-groups via the reaction of thiol-disulfide exchange resulting in the loss of reducing activity for cytochrome c.	Sulfhydryl Compounds	92-97	cytochrome c, somatic	Homo sapiens	164-176
8328983-7	1993	These results taken together suggest that delta 12-PGJ2 binds to the thiol groups of nuclear proteins and activates HSF, leading to the synthesis of the 67-kDa HSP.	Sulfhydryl Compounds	69-74	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	160-163
8389858-11	1993	The results suggest that sulfhydryl supplementation modifies the function of the renin/angiotensin system in vivo, an effect probably mediated by inhibition of angiotensin converting enzyme activity.	Sulfhydryl Compounds	25-35	renin	Rattus norvegicus	81-86
8327999-8	1993	Further, total thiol was depleted in serum and lung tissue, accompanied with a significant decrease in activity of glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and glutathione S-transferase.	Sulfhydryl Compounds	15-20	glutathione-disulfide reductase	Rattus norvegicus	139-160
8327999-8	1993	Further, total thiol was depleted in serum and lung tissue, accompanied with a significant decrease in activity of glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and glutathione S-transferase.	Sulfhydryl Compounds	15-20	glucose-6-phosphate dehydrogenase	Rattus norvegicus	162-195
8327999-8	1993	Further, total thiol was depleted in serum and lung tissue, accompanied with a significant decrease in activity of glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase, and glutathione S-transferase.	Sulfhydryl Compounds	15-20	hematopoietic prostaglandin D synthase	Rattus norvegicus	201-226
8512582-3	1993	On the basis of the presence of at least one thiol group essential for the activity of catechol-O-methyltransferase (COMT), several 1-vinyl derivatives of nitrocatechol and nitroguaiacol were synthesized and tested as potential irreversible active site-directed inhibitors of COMT.	Sulfhydryl Compounds	45-50	catechol-O-methyltransferase	Sus scrofa	87-115
8512582-3	1993	On the basis of the presence of at least one thiol group essential for the activity of catechol-O-methyltransferase (COMT), several 1-vinyl derivatives of nitrocatechol and nitroguaiacol were synthesized and tested as potential irreversible active site-directed inhibitors of COMT.	Sulfhydryl Compounds	45-50	catechol-O-methyltransferase	Sus scrofa	117-121
8512582-6	1993	When the inhibition of COMT was measured as a function of the length of time of pre-incubation with 2, biphasic kinetics were observed, suggesting the modification of at least two thiol groups which are essential for COMT activity.	Sulfhydryl Compounds	180-185	catechol-O-methyltransferase	Sus scrofa	23-27
8387753-6	1993	Here we report that the human ectoCa(2+)-ATPase is biochemically similar to the major rat hepatocyte ectoATPase/cell adhesion molecule (cell-CAM 105) with respect to response to divalent ions and sulfhydryl reagents.	Sulfhydryl Compounds	196-206	dynein axonemal heavy chain 8	Homo sapiens	41-47
8387753-6	1993	Here we report that the human ectoCa(2+)-ATPase is biochemically similar to the major rat hepatocyte ectoATPase/cell adhesion molecule (cell-CAM 105) with respect to response to divalent ions and sulfhydryl reagents.	Sulfhydryl Compounds	196-206	CEA cell adhesion molecule 1	Rattus norvegicus	101-111
8512582-6	1993	When the inhibition of COMT was measured as a function of the length of time of pre-incubation with 2, biphasic kinetics were observed, suggesting the modification of at least two thiol groups which are essential for COMT activity.	Sulfhydryl Compounds	180-185	catechol-O-methyltransferase	Sus scrofa	217-221
8387753-6	1993	Here we report that the human ectoCa(2+)-ATPase is biochemically similar to the major rat hepatocyte ectoATPase/cell adhesion molecule (cell-CAM 105) with respect to response to divalent ions and sulfhydryl reagents.	Sulfhydryl Compounds	196-206	CEA cell adhesion molecule 1	Rattus norvegicus	136-148
8482850-2	1993	A bispecific antibody recognizing both the alpha- and beta-chains of the IL-2R was generated by sulfhydryl-directed chemical reassociation of monovalent Fab" fragments prepared from the anti-alpha mAb 33B3.1 (rat IgG2a) and from the anti-beta mAb A41 (mouse IgG1).	Sulfhydryl Compounds	96-106	interleukin 2 receptor subunit alpha	Homo sapiens	73-78
8389126-0	1993	Sulphydryl agents modulate insulin- and epidermal growth factor (EGF)-receptor kinase via reaction with intracellular receptor domains: differential effects on basal versus activated receptors.	Sulfhydryl Compounds	0-10	insulin	Homo sapiens	27-34
8389126-0	1993	Sulphydryl agents modulate insulin- and epidermal growth factor (EGF)-receptor kinase via reaction with intracellular receptor domains: differential effects on basal versus activated receptors.	Sulfhydryl Compounds	0-10	epidermal growth factor receptor	Homo sapiens	40-78
8482850-2	1993	A bispecific antibody recognizing both the alpha- and beta-chains of the IL-2R was generated by sulfhydryl-directed chemical reassociation of monovalent Fab" fragments prepared from the anti-alpha mAb 33B3.1 (rat IgG2a) and from the anti-beta mAb A41 (mouse IgG1).	Sulfhydryl Compounds	96-106	FA complementation group B	Homo sapiens	153-156
8491204-5	1993	The chromogranin B molecules diverted to constitutive secretory vesicles, in contrast to those stored in secretory granules, were found to contain free sulfhydryl residues.	Sulfhydryl Compounds	152-162	chromogranin B	Rattus norvegicus	4-18
8389126-9	1993	Our results suggest that complex sulphydryl interactions can occur within the cytoplasmic domain of insulin- and EGF-receptors to alter receptor kinase activity.	Sulfhydryl Compounds	33-43	insulin	Homo sapiens	100-107
8389126-9	1993	Our results suggest that complex sulphydryl interactions can occur within the cytoplasmic domain of insulin- and EGF-receptors to alter receptor kinase activity.	Sulfhydryl Compounds	33-43	epidermal growth factor	Homo sapiens	113-116
8318649-9	1993	Incubation of Co(II) with cumene-OOH ort-butyl-OOH in the presence of the histidyl oligopeptide Gly-Gly-His also generated lipid hydroperoxide-derived free radicals, with the yield being comparable to that obtained using thiols.	Sulfhydryl Compounds	221-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-20
8387210-3	1993	This suggested that the disulfides of both macromolecules might be cleaved by a thiol-disulfide interchange reaction, possibly mediated by protein disulfide-isomerase (PDI, EC 5.3.4.1).	Sulfhydryl Compounds	80-85	protein disulfide-isomerase	Cricetulus griseus	139-166
8387210-3	1993	This suggested that the disulfides of both macromolecules might be cleaved by a thiol-disulfide interchange reaction, possibly mediated by protein disulfide-isomerase (PDI, EC 5.3.4.1).	Sulfhydryl Compounds	80-85	protein disulfide-isomerase	Cricetulus griseus	168-171
8463316-1	1993	Wheat calmodulin (CaM) was labeled at Cys-27 with the sulfhydryl-specific fluorescent probe 2-(4"-maleimidoanilino)-naphthalene-6-sulfonic acid (MIANS), to form MIANS.CaM.	Sulfhydryl Compounds	54-64	CaM5	Triticum aestivum	6-16
8463316-1	1993	Wheat calmodulin (CaM) was labeled at Cys-27 with the sulfhydryl-specific fluorescent probe 2-(4"-maleimidoanilino)-naphthalene-6-sulfonic acid (MIANS), to form MIANS.CaM.	Sulfhydryl Compounds	54-64	CaM5	Triticum aestivum	18-21
8466903-1	1993	Activation of the enediyne neocarzinostatin chromophore (NCS-Chrom) by thiol addition at C-12 generates a diradical species with radical centers at C-2 and C-6, which abstract hydrogens from deoxyribose in the minor groove of DNA.	Sulfhydryl Compounds	71-76	complement C2	Homo sapiens	148-151
8466903-1	1993	Activation of the enediyne neocarzinostatin chromophore (NCS-Chrom) by thiol addition at C-12 generates a diradical species with radical centers at C-2 and C-6, which abstract hydrogens from deoxyribose in the minor groove of DNA.	Sulfhydryl Compounds	71-76	complement C6	Homo sapiens	156-159
8466913-0	1993	Differential effects of the reversible thiol-reactive agents arsenite and methyl methanethiosulfonate on steroid binding by the glucocorticoid receptor.	Sulfhydryl Compounds	39-44	nuclear receptor subfamily 3 group C member 1	Homo sapiens	128-151
8098618-10	1993	In parallel, CD2 + CD28 activation triggered a significant intracellular thiol decrease, suggesting that oxygen radicals are involved in the signaling pathway of adhesion molecules.	Sulfhydryl Compounds	73-78	CD2 molecule	Homo sapiens	13-16
8385903-1	1993	Under nondenaturing conditions, 1 mol of horse plasma gelsolin reacts with 1.9 +/- 0.5 mol (mean +/- SD, n = 6) of the sulfhydryl-specific fluorescent reagent 6-acryloyl-2-dimethylaminonaphthalene (acrylodan).	Sulfhydryl Compounds	119-129	gelsolin	Equus caballus	54-62
8098618-10	1993	In parallel, CD2 + CD28 activation triggered a significant intracellular thiol decrease, suggesting that oxygen radicals are involved in the signaling pathway of adhesion molecules.	Sulfhydryl Compounds	73-78	CD28 molecule	Homo sapiens	19-23
8387793-0	1993	Modification of Cys-128 of pig kidney fructose 1,6-bisphosphatase with different thiol reagents: size dependent effect on the substrate and fructose-2,6-bisphosphate interaction.	Sulfhydryl Compounds	81-86	fructose-bisphosphatase 1	Sus scrofa	38-65
8261071-11	1993	In humans, plasma thiol levels decrease with increasing age, females have higher red cell glutathione and there is a significant inverse relationship between red blood cell superoxide dismutase and glutathione levels.	Sulfhydryl Compounds	18-23	superoxide dismutase 1	Homo sapiens	173-193
8444159-2	1993	Formation of mixed disulfides of the penultimate C-terminal cysteine residue 374 with various low-molecular-mass thiols resulted in filament destabilization, as reflected by an increase in critical concentration and steady-state ATPase activity.	Sulfhydryl Compounds	113-119	dynein axonemal heavy chain 8	Homo sapiens	229-235
8462229-6	1993	ACE inhibitors can be subdivided into 3 classes with regard to the active group: the majority of ACE inhibitors are carboxyl-containing drugs, a new class of ACE inhibitors possess a phosphoryl-group and captopril and related compounds are sulfhydryl-containing drugs.	Sulfhydryl Compounds	240-250	angiotensin I converting enzyme	Homo sapiens	0-3
8462726-6	1993	Sulfhydryl compounds (dithiothreitol and glutathione) or quinone-reducing agents (ascorbic acid) prevented the inactivation of ODC; L-ornithine, but not other amino acids, also protected partially ODC.	Sulfhydryl Compounds	0-20	ornithine decarboxylase 1	Homo sapiens	127-130
8462726-6	1993	Sulfhydryl compounds (dithiothreitol and glutathione) or quinone-reducing agents (ascorbic acid) prevented the inactivation of ODC; L-ornithine, but not other amino acids, also protected partially ODC.	Sulfhydryl Compounds	0-20	ornithine decarboxylase 1	Homo sapiens	197-200
8471182-0	1993	Thimet oligopeptidase--a review of a thiol dependent metallo-endopeptidase also known as Pz-peptidase endopeptidase 24.15 and endo-oligopeptidase.	Sulfhydryl Compounds	37-42	thimet oligopeptidase 1	Rattus norvegicus	0-21
8384500-3	1993	The solid supported membrane consists of a lipid monolayer on a gold evaporated or gold sputtered glass substrate which is coated with a long chained mercaptan (CH3(CH2)mSH, m = 15, 17).	Sulfhydryl Compounds	150-159	msh homeobox 1	Mus musculus	169-172
8471182-0	1993	Thimet oligopeptidase--a review of a thiol dependent metallo-endopeptidase also known as Pz-peptidase endopeptidase 24.15 and endo-oligopeptidase.	Sulfhydryl Compounds	37-42	thimet oligopeptidase 1	Rattus norvegicus	89-101
8471182-0	1993	Thimet oligopeptidase--a review of a thiol dependent metallo-endopeptidase also known as Pz-peptidase endopeptidase 24.15 and endo-oligopeptidase.	Sulfhydryl Compounds	37-42	thimet oligopeptidase 1	Rattus norvegicus	102-121
8471182-1	1993	Thimet oligopeptidase (EC 3.4.24.15) is a thiol-dependent metallo-endopeptidase also known as Pz-peptidase, collagenase-like peptidase, endooligopeptidase A, soluble metallo-endopeptidase and endopeptidase 24.15.	Sulfhydryl Compounds	42-47	thimet oligopeptidase 1	Rattus norvegicus	0-21
8471182-1	1993	Thimet oligopeptidase (EC 3.4.24.15) is a thiol-dependent metallo-endopeptidase also known as Pz-peptidase, collagenase-like peptidase, endooligopeptidase A, soluble metallo-endopeptidase and endopeptidase 24.15.	Sulfhydryl Compounds	42-47	thimet oligopeptidase 1	Rattus norvegicus	94-106
8471182-1	1993	Thimet oligopeptidase (EC 3.4.24.15) is a thiol-dependent metallo-endopeptidase also known as Pz-peptidase, collagenase-like peptidase, endooligopeptidase A, soluble metallo-endopeptidase and endopeptidase 24.15.	Sulfhydryl Compounds	42-47	thimet oligopeptidase 1	Rattus norvegicus	136-156
8471182-1	1993	Thimet oligopeptidase (EC 3.4.24.15) is a thiol-dependent metallo-endopeptidase also known as Pz-peptidase, collagenase-like peptidase, endooligopeptidase A, soluble metallo-endopeptidase and endopeptidase 24.15.	Sulfhydryl Compounds	42-47	thimet oligopeptidase 1	Rattus norvegicus	158-187
8471182-1	1993	Thimet oligopeptidase (EC 3.4.24.15) is a thiol-dependent metallo-endopeptidase also known as Pz-peptidase, collagenase-like peptidase, endooligopeptidase A, soluble metallo-endopeptidase and endopeptidase 24.15.	Sulfhydryl Compounds	42-47	thimet oligopeptidase 1	Rattus norvegicus	192-211
8382610-4	1993	The comparison shows that the effect of the substitution at position 30 is transmitted through the protein core to Cys10, the only thiol group in the TTR subunit, which becomes slightly more exposed.	Sulfhydryl Compounds	131-136	transthyretin	Homo sapiens	150-153
8462280-2	1993	Human and murine cytosolic epoxide hydrolase were inhibited by thiol-, imidazole- and carboxyl-selective reagents.	Sulfhydryl Compounds	63-68	epoxide hydrolase 2, cytoplasmic	Mus musculus	17-44
8358226-4	1993	A heavy metal ion such as Cu2+ (1 mM) and thiol-modifying 4-hydroxymercuribenzoate (50 microM) caused complete inhibition of the activities of cytosolic sialidase and membrane sialidase I, while no decrease in the activities of intralysosomal sialidase and membrane sialidase II was observed.	Sulfhydryl Compounds	42-47	neuraminidase 2	Rattus norvegicus	143-162
8425495-3	1993	We also detected an estrogen- and thiol-induced 22K PRL variant in the rat pituitary comigrating with a PRL product generated by in vitro processing with GK and carboxypeptidase-B.	Sulfhydryl Compounds	34-39	carboxypeptidase B1	Rattus norvegicus	161-179
8425495-7	1993	Western blot analysis of rat pituitary extracts with CT-antiserum specifically detected an estrogen- and thiol-induced 22K band that comigrated with a PRL product generated by in vitro processing with GK and carboxypeptidase-B.	Sulfhydryl Compounds	105-110	carboxypeptidase B1	Rattus norvegicus	208-226
8109331-3	1993	Incubation with a series of peptides derived from the peptide sequence around SH thiol group (Cys 707) resulted in a measurable increase in isometric tension and ATPase activity at sub-maximal concentrations of calcium but not at saturating levels of calcium activity, thus demonstrating a "calcium-sensitizing" effect of these peptides.	Sulfhydryl Compounds	81-86	dynein axonemal heavy chain 8	Homo sapiens	162-168
8420937-0	1993	Identification of vicinal thiols of phosphoenolpyruvate carboxykinase (GTP).	Sulfhydryl Compounds	26-32	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	36-69
8425544-6	1993	Electrospray mass spectrometric analysis of the purified protein demonstrated that the recombinant product corresponds to the native human lipocortin 1, without the initial methionine and with a free N-terminal alanine; tryptic peptide mapping by fast-atom-bombardment mass spectrometry showed that the recombinant protein contains cysteine residues at positions 263 and 324 with free thiol groups, whereas Cys270 and Cys343 are probably involved in an intrachain disulfide bridge.	Sulfhydryl Compounds	385-390	annexin A1	Homo sapiens	139-151
8430514-5	1993	The dithiol-disulfide loop represented by this structure is unique since the cystine closer to the N-terminus has a highly acidic thiol pKa (3.8 as determined for the pig liver enzyme) that contributes to the protein"s high S- nucleophilicity.	Sulfhydryl Compounds	6-11	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	136-139
7509109-8	1993	The fluorescent dye iodoacetamidofluorescein was covalently attached to the reactive thiol of the myosin molecule in muscle fibers.	Sulfhydryl Compounds	85-90	myosin heavy chain 14	Homo sapiens	98-104
8424675-0	1993	Thiol-dependent metal-catalyzed oxidation of bovine lens aldose reductase.	Sulfhydryl Compounds	0-5	aldose reductase	Bos taurus	57-73
8273544-6	1993	The depressed ATPase activity in rheumatoid MNC could thus be due to blockade/oxidation of a reactive surface thiol, and could contribute to perpetuation of the chronic inflammatory process in these patients.	Sulfhydryl Compounds	110-115	dynein axonemal heavy chain 8	Homo sapiens	14-20
7678726-6	1993	The ability of these agents to protect the three free thiol groups of aFGF from copper-catalyzed oxidation was also explored and significant protection was observed.	Sulfhydryl Compounds	54-59	fibroblast growth factor 1	Homo sapiens	70-74
8424675-3	1993	Bovine lens aldose reductase (alditol: NADP+ oxido-reductase, EC 1.1.1.21) undergoes a thiol-dependent oxidative modification catalyzed by the Fe(II)/Fe(III) redox system.	Sulfhydryl Compounds	87-92	aldose reductase	Bos taurus	12-28
8424676-0	1993	Thiol-dependent metal-catalyzed oxidation of bovine lens aldose reductase.	Sulfhydryl Compounds	0-5	aldose reductase	Bos taurus	57-73
8424686-0	1993	Modulation of glutathione S-transferase activity by a thiol/disulfide exchange reaction and involvement of thioltransferase.	Sulfhydryl Compounds	54-59	glutathione S-transferase kappa 1	Homo sapiens	14-39
8424686-1	1993	Low concentrations of cystamine and cystine inactivated human placenta glutathione S-transferase (GST-pi) in cytosolic fraction very effectively, as did the purified enzyme, through the thiol/disulfide exchange reaction.	Sulfhydryl Compounds	186-191	glutathione S-transferase kappa 1	Homo sapiens	71-96
8314111-0	1993	Inactivation of lipoamide dehydrogenase by cobalt(II) and iron(II) Fenton systems: effect of metal chelators, thiol compounds and adenine nucleotides.	Sulfhydryl Compounds	110-115	dihydrolipoamide dehydrogenase	Sus scrofa	16-39
8381319-15	1993	Sodium nitroprusside (80 JAM) or atrial natriuretic factor (ANF, I0- M) increased the levels of cyclic GMP in normal or tolerant SMC or EC to the same extent.5 The anti-platelet effects of GTN (44 JM) were potentiated by the sulphydryl donor N-acetylcysteine(NAC, 0.5mM).	Sulfhydryl Compounds	225-235	natriuretic peptide A	Homo sapiens	60-63
8428039-7	1993	This suggests that the acantholytic potential of thiol drugs is directly correlated to their capability of reducing PAI-1 in the epidermal cells leading to increased PA activity.	Sulfhydryl Compounds	49-54	serpin family E member 1	Homo sapiens	116-121
15091891-1	1993	Novel thio-substituted flexible polyurethane foam (T-PUF) was synthesised by addition polymerisation of mercaptan with the precursors of an open-cell polyurethane foam, which can be used as a highly selective sorbent for inorganic and organic mercury from complex matrices.	Sulfhydryl Compounds	104-113	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	53-56
8398344-1	1993	Neocarzinostatin (NCS) linked to the thiol group on the hinge region of the Fab" fragment of GA-17, a murine monoclonal antibody reacting with tyrosine-specific phosphorylated antigens, which are exclusively expressed on the cell surface of human astrocytomas, was evaluated for in vivo activity.	Sulfhydryl Compounds	37-42	FA complementation group B	Homo sapiens	76-79
8398344-1	1993	Neocarzinostatin (NCS) linked to the thiol group on the hinge region of the Fab" fragment of GA-17, a murine monoclonal antibody reacting with tyrosine-specific phosphorylated antigens, which are exclusively expressed on the cell surface of human astrocytomas, was evaluated for in vivo activity.	Sulfhydryl Compounds	37-42	eukaryotic translation initiation factor 3 subunit M	Homo sapiens	93-98
8397147-6	1993	Further experiments demonstrate that the reverse process can also occur: when hydroxyl radicals react with BSA, the thiol group appears to act as a radical sink and protects the protein from denaturation and fragmentation through the transfer of damage from a carbon site to the thiol group.	Sulfhydryl Compounds	116-121	albumin	Homo sapiens	107-110
8397147-6	1993	Further experiments demonstrate that the reverse process can also occur: when hydroxyl radicals react with BSA, the thiol group appears to act as a radical sink and protects the protein from denaturation and fragmentation through the transfer of damage from a carbon site to the thiol group.	Sulfhydryl Compounds	279-284	albumin	Homo sapiens	107-110
8397147-7	1993	Thiol-blocked BSA is shown to be more susceptible to damage than the native protein in both direct EPR experiments and enzyme digestion studies.	Sulfhydryl Compounds	0-5	albumin	Homo sapiens	14-17
8357331-4	1993	Although earlier studies suggested that sulfhydryl-containing ACE inhibitors scavenge superoxide anions, recent data have shown that these drugs scavenge hydroxyl radical and hypochlorous acid with no effect on superoxide anion.	Sulfhydryl Compounds	40-50	angiotensin I converting enzyme	Canis lupus familiaris	62-65
7834494-8	1993	We showed that reduction of this disulfide bond by incubation of intact PC12 cells with the membrane permeable thiol reducing agent dithiothreitol (DTT) causes the missorting of chromogranin B to the constitutive secretory pathway.	Sulfhydryl Compounds	111-116	chromogranin B	Rattus norvegicus	178-192
8380812-3	1993	There is also increasingly compelling evidence that thiols react in the presence of nitric oxide (NO) and endothelium-derived relaxing factor (EDRF) to form S-nitrosothiols, compounds with potent vasodilatory and antiplatelet effects.	Sulfhydryl Compounds	52-58	alpha hemoglobin stabilizing protein	Homo sapiens	106-141
8380812-3	1993	There is also increasingly compelling evidence that thiols react in the presence of nitric oxide (NO) and endothelium-derived relaxing factor (EDRF) to form S-nitrosothiols, compounds with potent vasodilatory and antiplatelet effects.	Sulfhydryl Compounds	52-58	alpha hemoglobin stabilizing protein	Homo sapiens	143-147
8259344-9	1993	These results suggest that (1) an LHRH-DA is found in the soluble fraction of rat prostate homogenate; (2) this enzymatic activity exhibits the characteristics of a metallo- and thiol-dependent neutral endopeptidase; (3) it appears to be different from similar hydrolytic activities found in other tissues; and (4) it is influenced by the hormonal milieu, since castration causes a significant decrease of its activity.	Sulfhydryl Compounds	178-183	gonadotropin releasing hormone 1	Rattus norvegicus	34-38
8148757-1	1993	The effect of NAC on exacerbation of chronic obstructive pulmonary disease (COPD) may be due to its mucolytic properties due to the thiol group of NAC and to its reducing and antioxidant properties.	Sulfhydryl Compounds	132-137	X-linked Kx blood group	Homo sapiens	14-17
8148757-1	1993	The effect of NAC on exacerbation of chronic obstructive pulmonary disease (COPD) may be due to its mucolytic properties due to the thiol group of NAC and to its reducing and antioxidant properties.	Sulfhydryl Compounds	132-137	X-linked Kx blood group	Homo sapiens	147-150
1458551-5	1992	The levels of cellular free protein thiols were shown to be depleted Hg2+ at significantly lower concentrations of the metal ion than those required to decrease the levels of the major cellular low-molecular weight thiol glutathione.	Sulfhydryl Compounds	36-42	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	69-72
1447207-0	1992	Inactivation of ribonuclease inhibitor by thiol-disulfide exchange.	Sulfhydryl Compounds	42-47	ribonuclease/angiogenin inhibitor 1	Homo sapiens	16-38
1487709-1	1992	The thiol activated endo-oligopeptidases A and B were studied in the soluble fraction of human hypothalamus and various endocrine glands.	Sulfhydryl Compounds	4-9	nudE neurodevelopment protein 1 like 1	Homo sapiens	20-48
1337996-2	1992	A recent study of a range of alkoxy- and alkylthio-phenol analogues of tyrosine has shown that sulphur-containing compounds exhibit different behaviour to that of similar oxygen-containing compounds, indicating modified reactivities of their corresponding tyrosinase-induced o-quinones towards crucial cellular targets, in particular, thiols.	Sulfhydryl Compounds	335-341	tyrosinase	Homo sapiens	256-266
1482376-5	1992	Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml).	Sulfhydryl Compounds	65-70	nuclear factor kappa B subunit 1	Homo sapiens	158-168
1482376-5	1992	Incubation of Jurkat T cells (1 x 10(6) cells/ml) with a natural thiol antioxidant, alpha-lipoic acid, prior to the stimulation of cells was found to inhibit NF-kappa B activation induced by tumor necrosis factor-alpha (25 ng/ml) or by phorbol 12-myristate 13-acetate (50 ng/ml).	Sulfhydryl Compounds	65-70	tumor necrosis factor	Homo sapiens	191-218
1282886-3	1992	In alpha 2M, in which the thiol ester is broken by binding of methylamine and the "trap" is closed, cyanylation of the liberated thiol group from the thiol ester modulates reopening of the "trap" and the "bait" regions become available for cleavage again.	Sulfhydryl Compounds	26-31	alpha-2-macroglobulin	Homo sapiens	3-11
1447182-10	1992	However, the thiol reducing agent, dithiothreitol, inhibited induction of hsp70 mRNA by NCC.	Sulfhydryl Compounds	13-18	heat shock protein family A (Hsp70) member 4	Homo sapiens	74-79
1447182-11	1992	The data suggest that covalent binding and alterations in cellular non-protein thiols serve as signals for activation of pre-existing transcription factors which increase hsp70 gene expression.	Sulfhydryl Compounds	79-85	heat shock protein family A (Hsp70) member 4	Homo sapiens	171-176
1458551-9	1992	Taken together, the toxicity of Hg2+ in human oral fibroblasts was demonstrated in several assays of which colony forming efficiency was the most sensitive, cell killing by this agent was related to its high affinity for protein thiols, whereas glutathione showed a significant, but limited, ability to protect the cells from Hg2+ toxicity.	Sulfhydryl Compounds	229-235	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	32-35
1446663-3	1992	The results of this investigation demonstrate that H2O2 generated during air oxidation of thiols is the main factor in non-turnover-dependent inactivation of purified recombinant human 5-lipoxygenase for the following reasons: catalase protects against oxygen-dependent inactivation of the enzyme in the presence of dithiothreitol; the active, stable enzyme can be prepared under aerobic conditions with the exclusion of dithiothreitol and contaminating metal ions; 10 microM H2O2 causes the rapid inactivation of the enzyme.	Sulfhydryl Compounds	90-96	arachidonate 5-lipoxygenase	Homo sapiens	185-199
1445361-12	1992	In addition, our findings suggest that thiol groups play an essential role in the binding of HMG1 and HMG2 to CDDP-DNA.	Sulfhydryl Compounds	39-44	high mobility group box 1 pseudogene 5	Homo sapiens	93-97
1445361-12	1992	In addition, our findings suggest that thiol groups play an essential role in the binding of HMG1 and HMG2 to CDDP-DNA.	Sulfhydryl Compounds	39-44	high mobility group box 2	Homo sapiens	102-106
1445854-8	1992	Cross-linking studies with 125I-ANP in the presence of sulfhydryl-modifying agent indicate that IDE activity is inhibited at the level of initial substrate binding whereas metal-ion chelating agents only prevent hydrolysis.	Sulfhydryl Compounds	55-65	natriuretic peptide A	Rattus norvegicus	32-35
1445854-8	1992	Cross-linking studies with 125I-ANP in the presence of sulfhydryl-modifying agent indicate that IDE activity is inhibited at the level of initial substrate binding whereas metal-ion chelating agents only prevent hydrolysis.	Sulfhydryl Compounds	55-65	insulin degrading enzyme	Rattus norvegicus	96-99
1446678-14	1992	In conclusion, 2-mercaptoethanol-dependent INS-1 cells, as well as RINm5F cells and islets of Langerhans, display a low capacity in maintaining intracellular levels of GSH in tissue culture without extracellular thiol supplementation; 2-mercaptoethanol possibly acts by promoting cyst(e)ine transport; changes in GSH levels caused a moderate effect on the differentiated function of insulin-secreting cells.	Sulfhydryl Compounds	212-217	insulin 1	Rattus norvegicus	43-48
1363429-4	1992	Tyrosinase was inhibited in L-ethionine-treated cells, probably because of metabolism of L-ethionine to sulfhydryl compounds; this remains to be clarified.	Sulfhydryl Compounds	104-124	tyrosinase	Homo sapiens	0-10
1447732-1	1992	Papain, a prototype cysteine protease, was inhibited in a time-dependent manner by azapeptide esters designed to deliver an azaglycine group to the active-site thiol.	Sulfhydryl Compounds	160-165	cathepsin B	Homo sapiens	20-37
1489830-3	1992	Carboxypeptidase H is a thiol-dependent metalloenzyme and contains a Zn2+ ion in its active center.	Sulfhydryl Compounds	24-29	carboxypeptidase E	Homo sapiens	0-18
1420173-1	1992	The major endogenous inhibitor of neutrophil elastase in the plasma, alpha 1-protease inhibitor (alpha 1-PI), has a single cysteine residue which has been shown to form mixed disulfides with a number of thiols in vitro.	Sulfhydryl Compounds	203-209	serpin family A member 1	Homo sapiens	69-95
1420173-1	1992	The major endogenous inhibitor of neutrophil elastase in the plasma, alpha 1-protease inhibitor (alpha 1-PI), has a single cysteine residue which has been shown to form mixed disulfides with a number of thiols in vitro.	Sulfhydryl Compounds	203-209	serpin family A member 1	Homo sapiens	97-107
1420173-2	1992	Under normal physiological conditions, the plasma concentrations of reduced and oxidized thiols are such that a major fraction of alpha 1-PI in the circulation in vivo is in the form of mixed disulfides [Laurell, C.-B.	Sulfhydryl Compounds	89-95	serpin family A member 1	Homo sapiens	130-140
1438209-0	1992	Homocysteine and other sulfhydryl compounds enhance the binding of lipoprotein(a) to fibrin: a potential biochemical link between thrombosis, atherogenesis, and sulfhydryl compound metabolism.	Sulfhydryl Compounds	23-33	lipoprotein(a)	Homo sapiens	67-81
1438209-12	1992	The observation that sulfhydryl amino acids increase Lp(a) binding to fibrin suggests a biochemical relationship between sulfhydryl compound metabolism, thrombosis, and atherogenesis.	Sulfhydryl Compounds	121-140	lipoprotein(a)	Homo sapiens	53-58
1283335-5	1992	We show here that insulin degrading enzyme (IDE), a neutral thiol metalloendoproteinase that is structurally non-homologous to the classical metallo, thiol, acid, or serine proteinases, is relatively specific in its proteolytic activity for insulin and digests human insulin (H(I)) into peptides that are presented by murine TA3 B cell antigen presenting cells (APCs) to HI/I-Ad-reactive T cells.	Sulfhydryl Compounds	60-65	insulin degrading enzyme	Homo sapiens	18-42
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	Sulfhydryl Compounds	120-125	glutathione S-transferase pi 1	Homo sapiens	0-27
1417864-1	1992	Glutathione S-transferase P (GST-P) lost the enzymatic activity by 7-fluoro-4-sulfamoyl-2, 1, 3-benzodiazole (ABD-F), a thiol-group chemical modifier, but did not by methylmethanethiol-sulfonate.	Sulfhydryl Compounds	120-125	glutathione S-transferase pi 1	Homo sapiens	29-34
1417983-7	1992	Moreover, the induction of heme oxygenase and p67 syntheses by the thiol-reactive agents arsenite and diethylmaleate was also inhibited by GSH treatment and enhanced by BSO treatment.	Sulfhydryl Compounds	67-72	CD33 molecule	Homo sapiens	46-49
1516169-2	1992	To monitor structural changes in the cardiac isoform of TnC (cTnC) associated with Ca2+ binding and crossbridge attachment in muscle, we labeled cTnC with the sulfhydryl-specific fluorescent probe 2-(4"-iodoacetamidoanilino)naphthalene-6-sulfonic acid (IAANS).	Sulfhydryl Compounds	159-169	tenascin C	Rattus norvegicus	56-59
1283335-5	1992	We show here that insulin degrading enzyme (IDE), a neutral thiol metalloendoproteinase that is structurally non-homologous to the classical metallo, thiol, acid, or serine proteinases, is relatively specific in its proteolytic activity for insulin and digests human insulin (H(I)) into peptides that are presented by murine TA3 B cell antigen presenting cells (APCs) to HI/I-Ad-reactive T cells.	Sulfhydryl Compounds	60-65	insulin degrading enzyme	Homo sapiens	44-47
1283335-5	1992	We show here that insulin degrading enzyme (IDE), a neutral thiol metalloendoproteinase that is structurally non-homologous to the classical metallo, thiol, acid, or serine proteinases, is relatively specific in its proteolytic activity for insulin and digests human insulin (H(I)) into peptides that are presented by murine TA3 B cell antigen presenting cells (APCs) to HI/I-Ad-reactive T cells.	Sulfhydryl Compounds	60-65	insulin	Homo sapiens	18-25
1390688-3	1992	This interaction stabilizes aFGF to thermal denaturation and partially protects a free thiol in its polyanion binding site from oxidation.	Sulfhydryl Compounds	87-92	fibroblast growth factor 1	Homo sapiens	28-32
1449601-0	1992	The molybdoenzymes xanthine oxidase and aldehyde oxidase contain fast- and slow-DTNB reacting sulphydryl groups.	Sulfhydryl Compounds	94-104	aldehyde oxidase 1	Homo sapiens	40-56
1449601-0	1992	The molybdoenzymes xanthine oxidase and aldehyde oxidase contain fast- and slow-DTNB reacting sulphydryl groups.	Sulfhydryl Compounds	94-104	dystrobrevin beta	Homo sapiens	80-84
1449601-1	1992	The reactivities with an excess of 5-5"-dithiobis (2-nitrobenzoic) acid (DTNB) of sulphydryl residues present in xanthine oxidase and aldehyde oxidase were studied and compared.	Sulfhydryl Compounds	82-92	dystrobrevin beta	Homo sapiens	73-77
1449601-3	1992	Some of the available sulphydryl residues thus react instantaneously with the DTNB, whereas the others react very slowly following pseudo-first-order kinetics.	Sulfhydryl Compounds	22-32	dystrobrevin beta	Homo sapiens	78-82
1449601-4	1992	The number of sulphydryl residues of each class and the rate constant of slowly reacting groups are, respectively, 1.7 and 0.8 in native xanthine oxidase and 1.6 and 1.7 in native aldehyde oxidase.	Sulfhydryl Compounds	14-24	aldehyde oxidase 1	Homo sapiens	180-196
1449601-5	1992	In denatured enzymes, the number of fast- and slow-reacting sulphydryl residues obtained are, respectively, 13.9 and 7.9 in xanthine oxidase and 5.7 and 5.4 in aldehyde oxidase.	Sulfhydryl Compounds	60-70	aldehyde oxidase 1	Homo sapiens	160-176
1401944-1	1992	Insulin autoantibodies (IAA), a marker for insulin-dependent diabetes mellitus (IDDM), have been reported in other diseases such as thyroid disease and after treatment with sulfhydryl containing medications.	Sulfhydryl Compounds	173-183	insulin	Homo sapiens	0-7
1381402-0	1992	Influence of free thiol group(s) on autoantibody-defined epitope of proliferating cell nuclear antigen.	Sulfhydryl Compounds	18-23	proliferating cell nuclear antigen	Homo sapiens	68-102
1330064-1	1992	The sulfhydryl reducing agent dithiothreitol (DTT) and the oxidizing agent 5,5-dithio-bis-2-nitrobenzoic acid (DTNB) reversibly modulate the component of synaptic potentials mediated by N-methyl-D-aspartate (NMDA) receptors in slices of hippocampal area CA1.	Sulfhydryl Compounds	4-14	carbonic anhydrase 1	Homo sapiens	254-257
1457216-1	1992	Adult T-cell leukemia (ATL)-derived factor (ADF) is a multifunctional protein homologous to thioredoxin (TRX) with co-cytokine and thiol-dependent reducing activities.	Sulfhydryl Compounds	131-136	thioredoxin	Homo sapiens	44-47
1457216-1	1992	Adult T-cell leukemia (ATL)-derived factor (ADF) is a multifunctional protein homologous to thioredoxin (TRX) with co-cytokine and thiol-dependent reducing activities.	Sulfhydryl Compounds	131-136	thioredoxin	Homo sapiens	92-103
1457216-1	1992	Adult T-cell leukemia (ATL)-derived factor (ADF) is a multifunctional protein homologous to thioredoxin (TRX) with co-cytokine and thiol-dependent reducing activities.	Sulfhydryl Compounds	131-136	thioredoxin	Homo sapiens	105-108
1330169-16	1992	This probably involves binding of Cd2+" at an extracellular thiol site on, or close to, voltage-operated Ca2+" channels.	Sulfhydryl Compounds	60-65	CD2 antigen	Mus musculus	34-37
1420910-0	1992	Cooperativity of thiol-modified myosin filaments.	Sulfhydryl Compounds	17-22	myosin heavy chain 14	Homo sapiens	32-38
1445998-3	1992	1H NMR spectral analyses revealed that two singlet signals of olefinic protons of N-methyldehydroalanine (Mdha) in microcystins disappeared in the conjugates, confirming that thiols of GSH and Cys added nucleophilically to the alpha, beta-unsaturated carbonyl of the Mdha moiety.	Sulfhydryl Compounds	175-181	malate dehydrogenase 1, NAD (soluble)	Mus musculus	106-110
1386605-3	1992	Our analysis, employing a thiol-cleavable and homobifunctional chemical cross-linker, dithiobis succinimidyl propionate, revealed that CD45 indeed formed homodimers.	Sulfhydryl Compounds	26-31	protein tyrosine phosphatase receptor type C	Homo sapiens	135-139
1325644-1	1992	Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme"s single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol protein adduct.	Sulfhydryl Compounds	143-153	plasminogen activator, tissue type	Homo sapiens	0-33
1325644-1	1992	Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme"s single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol protein adduct.	Sulfhydryl Compounds	143-153	plasminogen activator, tissue type	Homo sapiens	35-39
1325644-1	1992	Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme"s single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol protein adduct.	Sulfhydryl Compounds	143-153	alpha hemoglobin stabilizing protein	Homo sapiens	65-100
1325644-1	1992	Tissue-type plasminogen activator (t-PA) reacts upon exposure to endothelium-derived relaxing factor (EDRF) by way of the enzyme"s single free sulfhydryl (Cys-83) to form a stable S-nitrosothiol protein adduct.	Sulfhydryl Compounds	143-153	alpha hemoglobin stabilizing protein	Homo sapiens	102-106
1359807-4	1992	The fluorescent characteristics of fluorescein were conserved in FTI after linkage with the thiol NEP inhibitor.	Sulfhydryl Compounds	92-97	membrane metalloendopeptidase	Homo sapiens	98-101
1329679-2	1992	On some B27 molecules the thiol (-SH) side chain of this residue seems to be available for chemical interactions.	Sulfhydryl Compounds	26-31	melanocortin 2 receptor accessory protein	Homo sapiens	8-11
1511689-1	1992	Aminopeptidase H was purified from fresh chicken breast muscle by ammonium sulfate fractionation and successive chromatographies on DEAE-cellulose, Ultrogel AcA 34, activated thiol-Sepharose 4B, phenyl-Sepharose CL-4B and DEAE-cellulose again.	Sulfhydryl Compounds	175-180	bleomycin hydrolase	Gallus gallus	0-16
1502182-2	1992	The single free cysteine of serum albumin, Cys-34, is particularly reactive toward nitrogen oxides (most likely nitrosonium ion) under physiologic conditions, primarily because of its anomalously low pK; given its abundance in plasma, where it accounts for approximately 0.5 mM thiol, we hypothesized that this plasma protein serves as a reservoir for nitric oxide produced by the endothelial cell.	Sulfhydryl Compounds	278-283	albumin	Homo sapiens	28-41
1379226-7	1992	Folylpolyglutamate hydrolase in permeabilized lysosomes from S180 cells exhibited a low pH optimum characteristic of a lysosomal enzyme, was activated at concentrations of reduced sulfhydryl at 0.1 mM and above, and exhibited Km values in the range of 0.2-3 microM that decreased with increase in polyglutamate chain length.	Sulfhydryl Compounds	180-190	gamma-glutamyl hydrolase	Mus musculus	0-28
1379247-2	1992	The RGD sequence is located in the type 3 repeat region of TSP that has multiple Ca2+ binding sites and is subject to a complex intramolecular thiol-disulfide isomerization.	Sulfhydryl Compounds	143-148	thrombospondin 1	Homo sapiens	59-62
1387799-10	1992	These results indicate that among three ACE inhibitors, two sulfhydryl-containing drugs, captopril and zofenopril, possess cardioprotective as well as free-radical scavenging abilities.	Sulfhydryl Compounds	60-70	angiotensin I converting enzyme	Rattus norvegicus	40-43
1321713-7	1992	Selenite caused a strong dose-dependent inhibition of the formation of thiol groups from insulin disulfides with either the E. coli or calf-thymus thioredoxin system.	Sulfhydryl Compounds	71-76	thioredoxin	Bos taurus	147-158
1634535-6	1992	Subsequent mild treatment of the covalent thrombin-inhibitor complexes with NH2OH in the presence of 5-(iodoacetamido)fluorescein resulted in generation of the thiol group together with its selective modification and incorporation of 0.96 +/- 0.07 mol of probe/mol of active sites.	Sulfhydryl Compounds	160-165	coagulation factor II, thrombin	Homo sapiens	42-50
1634536-4	1992	An array of 16 thrombin derivatives was prepared by affinity labeling of the proteinase active site with the thioester peptide chloromethyl ketones, N alpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl or N alpha-[(acetylthio)acetyl]-D-Phe-Phe-Arg-CH2Cl, followed by selective modification of the NH2OH-generated thiol group on the covalently incorporated inhibitors with each of eight thiol-reactive fluorescence probes.	Sulfhydryl Compounds	309-314	coagulation factor II, thrombin	Homo sapiens	15-23
1634536-4	1992	An array of 16 thrombin derivatives was prepared by affinity labeling of the proteinase active site with the thioester peptide chloromethyl ketones, N alpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl or N alpha-[(acetylthio)acetyl]-D-Phe-Phe-Arg-CH2Cl, followed by selective modification of the NH2OH-generated thiol group on the covalently incorporated inhibitors with each of eight thiol-reactive fluorescence probes.	Sulfhydryl Compounds	309-314	endogenous retrovirus group K member 18	Homo sapiens	77-87
1634536-4	1992	An array of 16 thrombin derivatives was prepared by affinity labeling of the proteinase active site with the thioester peptide chloromethyl ketones, N alpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl or N alpha-[(acetylthio)acetyl]-D-Phe-Phe-Arg-CH2Cl, followed by selective modification of the NH2OH-generated thiol group on the covalently incorporated inhibitors with each of eight thiol-reactive fluorescence probes.	Sulfhydryl Compounds	382-387	coagulation factor II, thrombin	Homo sapiens	15-23
1634536-4	1992	An array of 16 thrombin derivatives was prepared by affinity labeling of the proteinase active site with the thioester peptide chloromethyl ketones, N alpha-[(acetylthio)acetyl]-D-Phe-Pro-Arg-CH2Cl or N alpha-[(acetylthio)acetyl]-D-Phe-Phe-Arg-CH2Cl, followed by selective modification of the NH2OH-generated thiol group on the covalently incorporated inhibitors with each of eight thiol-reactive fluorescence probes.	Sulfhydryl Compounds	382-387	endogenous retrovirus group K member 18	Homo sapiens	77-87
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Sulfhydryl Compounds	22-27	complement C5	Homo sapiens	148-151
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Sulfhydryl Compounds	22-27	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	154-157
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Sulfhydryl Compounds	22-27	complement C4A (Rodgers blood group)	Homo sapiens	164-167
1321713-3	1992	In contrast, thioredoxin reductase from Escherichia coli showed no direct reaction with selenite, but addition of 3 microM E. coli thioredoxin also resulted in non-stoichiometric oxidation of NADPH, consistent with oxidation of the two active-site thiol groups in thioredoxin to a disulfide.	Sulfhydryl Compounds	248-253	thioredoxin	Bos taurus	13-24
1321713-3	1992	In contrast, thioredoxin reductase from Escherichia coli showed no direct reaction with selenite, but addition of 3 microM E. coli thioredoxin also resulted in non-stoichiometric oxidation of NADPH, consistent with oxidation of the two active-site thiol groups in thioredoxin to a disulfide.	Sulfhydryl Compounds	248-253	thioredoxin	Bos taurus	131-142
1321713-3	1992	In contrast, thioredoxin reductase from Escherichia coli showed no direct reaction with selenite, but addition of 3 microM E. coli thioredoxin also resulted in non-stoichiometric oxidation of NADPH, consistent with oxidation of the two active-site thiol groups in thioredoxin to a disulfide.	Sulfhydryl Compounds	248-253	thioredoxin	Bos taurus	131-142
1364150-3	1992	We found that homocysteine and other sulfhydryl-containing amino acids markedly increase the binding of Lp(a) to plasmin-modified fibrin.	Sulfhydryl Compounds	37-47	plasminogen	Bos taurus	104-109
1529807-2	1992	Captopril, an angiotensin converting enzyme (ACE) inhibitor, has free radical scavenging ability, attributable to its thiol group.	Sulfhydryl Compounds	118-123	angiotensin I converting enzyme	Homo sapiens	14-43
1529807-2	1992	Captopril, an angiotensin converting enzyme (ACE) inhibitor, has free radical scavenging ability, attributable to its thiol group.	Sulfhydryl Compounds	118-123	angiotensin I converting enzyme	Homo sapiens	45-48
1499287-7	1992	Cathepsin H had a pH and temperature optimum of 6.5 and 45 degrees C using Arg-MCA as a substrate, respectively, and was activated by sulfhydryl compounds and inhibited by cysteine protease inhibitors and metal compounds having high reactivities at cysteine residue.	Sulfhydryl Compounds	134-144	cathepsin H	Rattus norvegicus	0-11
1391615-6	1992	In contrast, free thiol levels decreased from a maximum immediately following CS2 exposure to near-base-line levels after 10 days, consistent with time-dependent conversion of initially formed N-substituted dithiocarbamate adducts into secondary products.	Sulfhydryl Compounds	18-23	chorionic somatomammotropin hormone 2	Homo sapiens	78-81
1392297-0	1992	Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat.	Sulfhydryl Compounds	38-43	cathepsin E	Rattus norvegicus	118-129
1333237-1	1992	Horse plasma gelsolin was labelled with the sulfhydryl-specific fluorescent reagent N-(1-pyrenyl)iodoacetamide.	Sulfhydryl Compounds	44-54	gelsolin	Equus caballus	13-21
1498089-0	1992	Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism.	Sulfhydryl Compounds	136-141	thioredoxin	Homo sapiens	6-17
1397500-4	1992	The effect of Cd2+ on the GR binding activity can be reversed with DTT, suggesting Cd2+ interaction with thiol groups.	Sulfhydryl Compounds	105-110	Cd2 molecule	Rattus norvegicus	14-17
1597467-1	1992	The involvement of a vicinally spaced dithiol group in steroid binding to the glucocorticoid receptor has been deduced from experiments with the thiol-specific reagent methyl methanethiolsulfonate and the vicinal dithiol-specific reagent sodium arsenite.	Sulfhydryl Compounds	40-45	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-101
1397500-4	1992	The effect of Cd2+ on the GR binding activity can be reversed with DTT, suggesting Cd2+ interaction with thiol groups.	Sulfhydryl Compounds	105-110	Cd2 molecule	Rattus norvegicus	83-86
1397500-6	1992	Cd(2+)-related GR modification seems to be mediated by Cd2+ binding to cytoplasmic components included in the regulation of the receptor function, although the direct binding of the metal to the receptor thiols could not be ruled out.	Sulfhydryl Compounds	204-210	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	15-17
1320058-1	1992	The effect of sulfhydryl-containing compounds on the specific binding of the neuropeptide vasoactive intestinal peptide (VIP) to murine lymphocytes was studied.	Sulfhydryl Compounds	14-24	vasoactive intestinal polypeptide	Mus musculus	121-124
1320058-3	1992	A sulfhydryl-containing analogue of VIP, [Cys2]VIP, was synthesized.	Sulfhydryl Compounds	2-12	vasoactive intestinal polypeptide	Mus musculus	36-39
1320058-3	1992	A sulfhydryl-containing analogue of VIP, [Cys2]VIP, was synthesized.	Sulfhydryl Compounds	2-12	vasoactive intestinal polypeptide	Mus musculus	47-50
1375939-11	1992	The differences between human FGF-1 and FGF-2 in protein-copper interactions may be due to differing free thiol content and arrangement between the two proteins.	Sulfhydryl Compounds	106-111	fibroblast growth factor 1	Homo sapiens	30-35
1375939-11	1992	The differences between human FGF-1 and FGF-2 in protein-copper interactions may be due to differing free thiol content and arrangement between the two proteins.	Sulfhydryl Compounds	106-111	fibroblast growth factor 2	Homo sapiens	40-45
1399955-6	1992	Experiments using radioactive N-ethylmaleimide to label proteins possessing a thiol residue, indicated that proteins L24, L10 and L11 are not only close to each other in the ribosomal structure, but are also adjacent (if not actually part of) the channel through which newly synthesized proteins are extruded.	Sulfhydryl Compounds	78-83	immunoglobulin kappa variable 1D-8	Homo sapiens	117-120
1399955-6	1992	Experiments using radioactive N-ethylmaleimide to label proteins possessing a thiol residue, indicated that proteins L24, L10 and L11 are not only close to each other in the ribosomal structure, but are also adjacent (if not actually part of) the channel through which newly synthesized proteins are extruded.	Sulfhydryl Compounds	78-83	ribosomal protein L10	Homo sapiens	122-125
1399955-6	1992	Experiments using radioactive N-ethylmaleimide to label proteins possessing a thiol residue, indicated that proteins L24, L10 and L11 are not only close to each other in the ribosomal structure, but are also adjacent (if not actually part of) the channel through which newly synthesized proteins are extruded.	Sulfhydryl Compounds	78-83	immunoglobulin kappa variable 1-6	Homo sapiens	130-133
1320058-8	1992	This may reflect a role of serine2 in hydrogen-bond formation during ligand-receptor interactions, or a functional role of sulfhydryl-containing residues of the VIP receptor in maintaining the integrity of the binding site of the VIP receptor on lymphocytes.	Sulfhydryl Compounds	123-133	vasoactive intestinal polypeptide	Mus musculus	161-164
1320058-8	1992	This may reflect a role of serine2 in hydrogen-bond formation during ligand-receptor interactions, or a functional role of sulfhydryl-containing residues of the VIP receptor in maintaining the integrity of the binding site of the VIP receptor on lymphocytes.	Sulfhydryl Compounds	123-133	vasoactive intestinal polypeptide	Mus musculus	230-233
1639112-1	1992	We studied the effect of the sulfhydryl reducing agent dithiothreitol on the binding of the angiotensin II agonist [125I][Sar1]-angiotensin II to AT2 receptors in selected brain areas of young (2-week-old) rats.	Sulfhydryl Compounds	29-39	angiotensinogen	Rattus norvegicus	92-106
1639112-1	1992	We studied the effect of the sulfhydryl reducing agent dithiothreitol on the binding of the angiotensin II agonist [125I][Sar1]-angiotensin II to AT2 receptors in selected brain areas of young (2-week-old) rats.	Sulfhydryl Compounds	29-39	angiotensinogen	Rattus norvegicus	128-142
1315290-9	1992	2-Mercaptoethanol, at millimolar concentration, induces RBP secretion, suggesting a possible role for sulfhydryl-mediated apo-RBP retention by resident ER proteins.	Sulfhydryl Compounds	102-112	retinol binding protein 4	Homo sapiens	56-59
1597148-1	1992	PRL transformation involves a dopamine (DA)-controlled, thiol-mediated decrease in pituitary PRL detectability that precedes and may determine increased PRL release.	Sulfhydryl Compounds	56-61	prolactin	Rattus norvegicus	0-3
1597148-1	1992	PRL transformation involves a dopamine (DA)-controlled, thiol-mediated decrease in pituitary PRL detectability that precedes and may determine increased PRL release.	Sulfhydryl Compounds	56-61	prolactin	Rattus norvegicus	93-96
1597148-1	1992	PRL transformation involves a dopamine (DA)-controlled, thiol-mediated decrease in pituitary PRL detectability that precedes and may determine increased PRL release.	Sulfhydryl Compounds	56-61	prolactin	Rattus norvegicus	93-96
1381185-1	1992	C-Terminal cholecystokinin (CCK)-peptides of increasing chain lengths were all linked at their N-termini to the single surface-exposed cysteine residue 107 of yeast iso-1-cytochrome c by the maleimide/thiol reaction.	Sulfhydryl Compounds	201-206	cholecystokinin	Cavia porcellus	28-31
1381185-1	1992	C-Terminal cholecystokinin (CCK)-peptides of increasing chain lengths were all linked at their N-termini to the single surface-exposed cysteine residue 107 of yeast iso-1-cytochrome c by the maleimide/thiol reaction.	Sulfhydryl Compounds	201-206	threonine ammonia-lyase ILV1	Saccharomyces cerevisiae S288C	165-170
1597148-17	1992	DA appears to inhibit PRL transformation by preventing thiol-disulfide interchange.	Sulfhydryl Compounds	55-60	prolactin	Rattus norvegicus	22-25
1315290-9	1992	2-Mercaptoethanol, at millimolar concentration, induces RBP secretion, suggesting a possible role for sulfhydryl-mediated apo-RBP retention by resident ER proteins.	Sulfhydryl Compounds	102-112	retinol binding protein 4	Homo sapiens	126-129
1373654-8	1992	The fluorescent dye (iodoacetamido)fluorescein was covalently attached to the reactive thiol of the myosin molecule in muscle fibers.	Sulfhydryl Compounds	87-92	myosin heavy chain 14	Homo sapiens	100-106
1567868-0	1992	Conserved residues flanking the thiol/disulfide centers of protein disulfide isomerase are not essential for catalysis of thiol/disulfide exchange.	Sulfhydryl Compounds	32-37	prolyl 4-hydroxylase subunit beta	Homo sapiens	59-86
1567868-3	1992	Available data indicate that the two thiol/disulfide centers of PDI can function independently in the isomerase reaction and that the cysteine residues in each active site are essential for catalysis.	Sulfhydryl Compounds	37-42	prolyl 4-hydroxylase subunit beta	Homo sapiens	64-67
1319206-4	1992	Affinity chromatography of heparin in cytochrome c immobilized to thiol-Sepharose shows that commercial heparin is eluted in the low-affinity and high-affinity fractions.	Sulfhydryl Compounds	66-71	cytochrome c, somatic	Homo sapiens	38-50
1533499-5	1992	ATPase activity was inhibited by low concentrations of p-chloromercuriphenyl sulfonate and the inhibition was reversed by cysteine which suggested that thiol groups were essential for activity.	Sulfhydryl Compounds	152-157	tRNA(Met) cytidine acetyltransferase TmcA	Saccharolobus solfataricus	0-6
1639768-1	1992	Thioltransferase, an enzyme which catalyzes the thiol/disulfide exchange reaction in the presence of GSH, was purified to homogeneity on 15% SDS-PAGE from human (36,000-fold purification) and bovine (23,000-fold) erythrocyte hemolysates.	Sulfhydryl Compounds	48-53	glutaredoxin	Homo sapiens	0-16
1568474-4	1992	Native human SP-B lacks free thiol groups.	Sulfhydryl Compounds	29-34	surfactant protein B	Homo sapiens	13-17
1413650-3	1992	The enzyme proved to be serine proteinase as shown by analysis using inhibitors; it required thiol groups.	Sulfhydryl Compounds	93-98	endogenous retrovirus group K member 25	Homo sapiens	31-41
1325466-1	1992	The thiol groups of leucinthiol, cysteamine and cysteine incorporated into opioid peptides enkephalin and morphiceptin were activated by the 3-nitro-2-pyridinesulphenyl (Npys) group to form mixed disulphides highly reactive to a free thiol.	Sulfhydryl Compounds	4-9	proenkephalin	Rattus norvegicus	91-101
1325466-1	1992	The thiol groups of leucinthiol, cysteamine and cysteine incorporated into opioid peptides enkephalin and morphiceptin were activated by the 3-nitro-2-pyridinesulphenyl (Npys) group to form mixed disulphides highly reactive to a free thiol.	Sulfhydryl Compounds	26-31	proenkephalin	Rattus norvegicus	91-101
1569576-6	1992	The sequence of this neuronal MHC is compared with those of other non-muscle MHCs, to which it shows an overall similarity of structure, especially with respect to conserved regions within the head (ATP binding site, actin binding site, reactive thiols) and the presence of an alpha-helical coiled-coil tail that can be arranged as 28-residue repeating units plus four skip residues.	Sulfhydryl Compounds	246-252	major histocompatibility complex, class I, C	Homo sapiens	30-33
1318718-3	1992	PQQ also catalyzes the oxidation of thiol groups critically connected with the function of two proteins, i.e. thioredoxin and phosphoribulose kinase.	Sulfhydryl Compounds	36-41	thioredoxin	Homo sapiens	110-121
1567427-0	1992	Tyrosine-7 in human class Pi glutathione S-transferase is important for lowering the pKa of the thiol group of glutathione in the enzyme-glutathione complex.	Sulfhydryl Compounds	96-101	glutathione S-transferase kappa 1	Homo sapiens	29-54
1375018-0	1992	Sulphydryl reactivity of the HLA-B27 epitope: accessibility of the free cysteine studied by flow cytometry.	Sulfhydryl Compounds	0-10	major histocompatibility complex, class I, B	Homo sapiens	29-36
1375018-2	1992	In a previous study it was shown that chemical treatment of HLA-B27 cells with the sulphydryl binding agent p-chloromercuriphenylsulphonic acid (pCMPSA) specifically reduced binding of antibodies to HLA-B27 by up to 80%, as measured in a cellular enzyme linked immunosorbent assay (CELISA).	Sulfhydryl Compounds	83-93	major histocompatibility complex, class I, B	Homo sapiens	60-65
1375018-2	1992	In a previous study it was shown that chemical treatment of HLA-B27 cells with the sulphydryl binding agent p-chloromercuriphenylsulphonic acid (pCMPSA) specifically reduced binding of antibodies to HLA-B27 by up to 80%, as measured in a cellular enzyme linked immunosorbent assay (CELISA).	Sulfhydryl Compounds	83-93	major histocompatibility complex, class I, B	Homo sapiens	60-67
1567380-7	1992	With respect to reaction type, the prosthetic group FAD, the molecular mass (66 kDa) and the contents of thiol and carbonyl groups, the polyamine oxidase from A. suum is similar to the isofunctional enzyme of mammalian tissue.	Sulfhydryl Compounds	105-110	polyamine oxidase	Homo sapiens	136-153
1318718-4	1992	The reaction of PQQ with reduced thioredoxin brings about the oxidation of two thiol groups of the oxireductase, whereas the enzyme phosphoribulose kinase is inactivated at 25 degrees C. The oxidized disulfide bond of phosphoribulose kinase is reduced by dithiothreitol and the enzyme recovers catalytic activity.	Sulfhydryl Compounds	79-84	thioredoxin	Homo sapiens	33-44
1314656-6	1992	In a different synthetic approach, selective modification of the thiol group of [Cys35]PTHrP(1-35)NH2, in solution, with N-biotinyl-N"-(6-maleimidohexanoyl)hydrazide, resulted in analogue 4.	Sulfhydryl Compounds	65-70	parathyroid hormone like hormone	Homo sapiens	87-92
1373797-9	1992	The serine protease inhibitor tosyl-lysyl chloromethyl ketone abolished the induction of NOS-II by INF/LPS, by depleting intracellular thiol pools and interfering with protein synthesis.	Sulfhydryl Compounds	135-140	nitric oxide synthase 2, inducible	Mus musculus	89-95
1516732-10	1992	Cathepsin A was inactivated rapidly and irreversibly by thiols.	Sulfhydryl Compounds	56-62	cathepsin A	Homo sapiens	0-11
1563102-1	1992	An impermeable thiol blocker has been used to investigate the role of sulphydryl (SH) groups in the production of and responsiveness to IL-2 by normal human T lymphocytes.	Sulfhydryl Compounds	15-20	interleukin 2	Homo sapiens	136-140
1563102-1	1992	An impermeable thiol blocker has been used to investigate the role of sulphydryl (SH) groups in the production of and responsiveness to IL-2 by normal human T lymphocytes.	Sulfhydryl Compounds	70-80	interleukin 2	Homo sapiens	136-140
1563102-6	1992	The surface thiol identified on the IL-2 receptor may be a candidate for oxidation on cells from patients with chronic inflammatory diseases such as rheumatoid arthritis and thus contribute to the aberrant function of T cells in these patients.	Sulfhydryl Compounds	12-17	interleukin 2 receptor subunit beta	Homo sapiens	36-49
1373797-9	1992	The serine protease inhibitor tosyl-lysyl chloromethyl ketone abolished the induction of NOS-II by INF/LPS, by depleting intracellular thiol pools and interfering with protein synthesis.	Sulfhydryl Compounds	135-140	interferon gamma	Mus musculus	99-102
1544916-3	1992	We employed spinach calmodulin labeled with the sulfhydryl-selective probe, 2-(4-maleimidoanilino)naphthalene-6-sulfonic acid, to measure changes in the fluorescence intensity of the 2-(4-maleimidoanilino)naphthalene-6-sulfonic acid-calmodulin upon binding to rabbit skeletal muscle myosin light chain kinase.	Sulfhydryl Compounds	48-58	calmodulin	Oryctolagus cuniculus	20-30
1378121-2	1992	Indeed, part of the protection afforded by the angiotensin-converting enzyme (ACE) inhibitor captopril in regional myocardial ischemia is attributed to its thiol group.	Sulfhydryl Compounds	156-161	angiotensin I converting enzyme	Rattus norvegicus	47-76
1551387-1	1992	Both thiol groups of native human pancreatic lipase can react with the new hydrophobic sulfhydryl reagent 5-dodecyldithio-2-nitrobenzoic acid (Dod-S-NbS) in the absence of a denaturing agent.	Sulfhydryl Compounds	5-10	pancreatic lipase	Homo sapiens	34-51
1551387-1	1992	Both thiol groups of native human pancreatic lipase can react with the new hydrophobic sulfhydryl reagent 5-dodecyldithio-2-nitrobenzoic acid (Dod-S-NbS) in the absence of a denaturing agent.	Sulfhydryl Compounds	5-10	nibrin	Homo sapiens	149-152
1558197-0	1992	Role of intracellular thiols in release of EDRF from cultured endothelial cells.	Sulfhydryl Compounds	22-28	alpha hemoglobin stabilizing protein	Homo sapiens	43-47
1558197-1	1992	The availability of intracellular reduced thiols, such as L-cysteine or glutathione (GSH), may be critically important for the biosynthesis of endothelium-derived relaxing factor (EDRF).	Sulfhydryl Compounds	42-48	alpha hemoglobin stabilizing protein	Homo sapiens	143-178
1558197-1	1992	The availability of intracellular reduced thiols, such as L-cysteine or glutathione (GSH), may be critically important for the biosynthesis of endothelium-derived relaxing factor (EDRF).	Sulfhydryl Compounds	42-48	alpha hemoglobin stabilizing protein	Homo sapiens	180-184
1378121-2	1992	Indeed, part of the protection afforded by the angiotensin-converting enzyme (ACE) inhibitor captopril in regional myocardial ischemia is attributed to its thiol group.	Sulfhydryl Compounds	156-161	angiotensin I converting enzyme	Rattus norvegicus	78-81
1531616-0	1992	Neocarzinostatin-mediated DNA damage in a model AGT.ACT site: mechanistic studies of thiol-sensitive partitioning of C4" DNA damage products.	Sulfhydryl Compounds	85-90	angiotensinogen	Homo sapiens	48-51
1531616-7	1992	Production of 3"-phosphoglycolate residues, restricted mainly to the T of AGT in bistranded lesions, correlated with the incidence of direct DS breaks in the AGT.ACT model and in plasmid DNA and appeared to be influenced by the reducing power of the thiol activator.	Sulfhydryl Compounds	250-255	angiotensinogen	Homo sapiens	158-161
1531616-3	1992	Structure-function studies revealed that a variety of different thiols produced bistranded lesions in this model by predominantly C4"-hydrogen atom abstraction (84-93%) at the T of AGT and C5"-hydrogen atom abstraction (87-91%) at the T of ACT.	Sulfhydryl Compounds	64-70	angiotensinogen	Homo sapiens	181-184
1733934-2	1992	Furthermore, thiol titration of bovine pituitary basic fibroblast growth factor (bFGF) indicates the presence of two free thiols, which is consistent with an intramolecular disulfide.	Sulfhydryl Compounds	13-18	fibroblast growth factor 2	Bos taurus	49-79
1737090-6	1992	Furthermore, there were increased amounts of thiol-free protein 4.1 in the thalassemic mice, compared with very small amounts in the control mice and intermediate amounts in the transgenic mice.	Sulfhydryl Compounds	45-50	erythrocyte membrane protein band 4.1	Mus musculus	56-67
1733934-2	1992	Furthermore, thiol titration of bovine pituitary basic fibroblast growth factor (bFGF) indicates the presence of two free thiols, which is consistent with an intramolecular disulfide.	Sulfhydryl Compounds	122-128	fibroblast growth factor 2	Bos taurus	81-85
1740136-1	1992	In thiol redox buffers at pH 8.0, rat liver ATP-citrate lyase is in equilibrium between an oxidised inactive form and a reduced active form.	Sulfhydryl Compounds	3-8	ATP citrate lyase	Rattus norvegicus	44-61
1733934-2	1992	Furthermore, thiol titration of bovine pituitary basic fibroblast growth factor (bFGF) indicates the presence of two free thiols, which is consistent with an intramolecular disulfide.	Sulfhydryl Compounds	13-18	fibroblast growth factor 2	Bos taurus	81-85
1733934-2	1992	Furthermore, thiol titration of bovine pituitary basic fibroblast growth factor (bFGF) indicates the presence of two free thiols, which is consistent with an intramolecular disulfide.	Sulfhydryl Compounds	122-128	fibroblast growth factor 2	Bos taurus	49-79
1542302-1	1992	ADF (adult T-cell leukemia-derived factor), an inducer of IL-2R with growth promoting activity, is a homologue of thioredoxin which is involved in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	152-157	thioredoxin	Homo sapiens	0-3
1735133-10	1992	Sulfhydryl compounds prevented and reversed the inhibition of PAF-AH caused by CSE.	Sulfhydryl Compounds	0-20	phospholipase A2 group VII	Homo sapiens	62-68
1311644-1	1992	The objective of this study was to determine whether the thiol drug, diethyldithiocarbamate (DEDC) and its two metabolites, disulfiram (DS) and carbon disulfide (CS2) could be used as inhibitors of cytochrome P-450IIE1 to protect hepatocytes from cytotoxic xenobiotics.	Sulfhydryl Compounds	57-62	calsyntenin 2	Rattus norvegicus	162-165
1310150-4	1992	To demonstrate that a protein kinase activity associates with cell surface EPOR, cells were incubated with biotinylated EPO and then cross-linked with a thiol-cleavable chemical cross-linker.	Sulfhydryl Compounds	153-158	erythropoietin receptor	Homo sapiens	75-79
1310150-4	1992	To demonstrate that a protein kinase activity associates with cell surface EPOR, cells were incubated with biotinylated EPO and then cross-linked with a thiol-cleavable chemical cross-linker.	Sulfhydryl Compounds	153-158	erythropoietin	Homo sapiens	75-78
1310150-7	1992	Under reducing conditions, the 72-kDa phosphorylated EPOR but not pp130 was immunoprecipitated with an anti-EPOR antibody, suggesting that the pp130 is bound to the EPOR by the thiol-cleavable chemical cross-linker.	Sulfhydryl Compounds	177-182	erythropoietin receptor	Homo sapiens	53-57
1570025-13	1992	It is concluded that a) a thioredoxin system in brain tissue reduces the interchain disulfide of two-chain tetanus toxin and botulinum neurotoxin A, b) tetanus toxin but not botulinum neurotoxin A consists of two electrophoretically distinct forms which differ by the thiol-disulfide status of their heavy chains, c) the disulfide loop within the heavy chain of tetanus toxin is resistant to the thioredoxin system.	Sulfhydryl Compounds	268-273	thioredoxin 1	Rattus norvegicus	26-37
1542302-1	1992	ADF (adult T-cell leukemia-derived factor), an inducer of IL-2R with growth promoting activity, is a homologue of thioredoxin which is involved in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	152-157	thioredoxin	Homo sapiens	5-41
1542302-1	1992	ADF (adult T-cell leukemia-derived factor), an inducer of IL-2R with growth promoting activity, is a homologue of thioredoxin which is involved in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	152-157	interleukin 2 receptor subunit alpha	Homo sapiens	58-63
1542302-1	1992	ADF (adult T-cell leukemia-derived factor), an inducer of IL-2R with growth promoting activity, is a homologue of thioredoxin which is involved in many thiol-dependent reducing reactions.	Sulfhydryl Compounds	152-157	thioredoxin	Homo sapiens	114-125
1731804-1	1992	Purified rat liver phenylalanine hydroxylase is inactivated in vitro by ascorbate and thiol compounds, dithiothreitol being the most effective inhibitor, with a second order rate constant for the inactivation of 0.066 +/- 0.002 mM-1.min-1 at 20 degrees C and pH 7.2.	Sulfhydryl Compounds	86-91	phenylalanine hydroxylase	Rattus norvegicus	19-44
1309791-5	1992	Conversely, all thiols interacted to different extent with the high oxidation state of myoglobin, i.e. ferrylmyoglobin, via two processes.	Sulfhydryl Compounds	16-22	myoglobin	Homo sapiens	87-96
1309791-6	1992	First, direct electron transfer to heme iron in ferrylmyoglobin (HX-FeIV=O) with formation of met-myoglobin (HX-FeIII) or oxymyoglobin (HX-FeIIO2); the former transition was effected by all thiols except dihydrolipoate, which facilitated the latter, i.e. the formation of the two-electron reduction product of ferrylmyoglobin.	Sulfhydryl Compounds	190-196	myoglobin	Homo sapiens	54-63
1309791-8	1992	The contribution of either direct electron transfer to the heme iron or nucleophilic addition depended on the physicochemical properties of the thiol involved and on the availability of H2O2 to reoxidize met-myoglobin to ferrylmyoglobin.	Sulfhydryl Compounds	144-149	myoglobin	Homo sapiens	208-217
1309791-12	1992	The biological significance of the above results is discussed in terms of the occurrence and distribution of high oxidation states of myoglobin, its specific participation in cellular injury, and its potential interaction with biologically important thiols leading to either recovery of myoglobin or generation of nonfunctional forms of the hemoprotein as sulfmyoglobin.	Sulfhydryl Compounds	250-256	myoglobin	Homo sapiens	134-143
1309791-12	1992	The biological significance of the above results is discussed in terms of the occurrence and distribution of high oxidation states of myoglobin, its specific participation in cellular injury, and its potential interaction with biologically important thiols leading to either recovery of myoglobin or generation of nonfunctional forms of the hemoprotein as sulfmyoglobin.	Sulfhydryl Compounds	250-256	myoglobin	Homo sapiens	287-296
1309791-0	1992	The reactivity of thiols and disulfides with different redox states of myoglobin.	Sulfhydryl Compounds	18-24	myoglobin	Homo sapiens	71-80
1731900-1	1992	Factor XIIIa (a2") is a homodimeric transglutaminase that is formed via limited alpha-thrombin-catalyzed proteolysis of the platelet (a2) or plasma (a2b2) factor XIII zymogen in a reaction that results in proteolytic removal of a 37-aminoacyl residue peptide from the N-terminus of the a chains and exposure of the active-site thiol group in the resulting a" chains of factor XIIIa.	Sulfhydryl Compounds	327-332	coagulation factor XIII A chain	Homo sapiens	0-12
1736887-5	1992	The results show that modification of a thiol group of the D2 dopamine receptor in the two lobes of the pituitary gland tested here significantly affects ligand binding.	Sulfhydryl Compounds	40-45	dopamine receptor D2	Homo sapiens	59-79
1510379-2	1992	Protein thiol modification during oxidative stress is normally associated with impairment of various cell functions, including inhibition of agonist-stimulated phosphoinositide metabolism, disruption of intracellular Ca2+ homeostasis, and perturbation of normal cytoskeletal organization.	Sulfhydryl Compounds	8-13	carbonic anhydrase 2	Homo sapiens	217-220
1443795-1	1992	We developed a method for the enzymatic assay of glutathione which is easy to practice, rapid, specific, based on the reaction of the thiol group of glutathione with dithiobis-nitrobenzoic acid after the action of glutathione reductase in the presence of NADPH.	Sulfhydryl Compounds	134-139	glutathione-disulfide reductase	Homo sapiens	214-235
1381615-3	1992	EDRF is suggested to be a nitrosyl complex of iron with low-molecular thiol-containing ligands, most probably with cysteine.	Sulfhydryl Compounds	70-75	alpha hemoglobin stabilizing protein	Homo sapiens	0-4
1340432-3	1992	The acid-soluble sulfhydryl content and activities of glutathione S-transferase and glutathione reductase increased significantly (p &lt; 0.01) whereas the activity of glutathione peroxidase decreased significantly (p &lt; 0.01) in the liver of pups exposed to BHA via milk.	Sulfhydryl Compounds	17-27	glutathione reductase	Mus musculus	84-105
1733562-10	1992	Finally, experiments involving prior reaction of AST IV with the thiol-blocking agent, N-ethylmaleimide, before measurement of enzyme activity showed essentially full loss of sulfotransferase activity and suggested that formation of AST IV cysteine-2AAF adducts could be a mechanism for enzyme inactivation.	Sulfhydryl Compounds	65-70	sulfotransferase family 1A member 1	Rattus norvegicus	49-55
1733562-10	1992	Finally, experiments involving prior reaction of AST IV with the thiol-blocking agent, N-ethylmaleimide, before measurement of enzyme activity showed essentially full loss of sulfotransferase activity and suggested that formation of AST IV cysteine-2AAF adducts could be a mechanism for enzyme inactivation.	Sulfhydryl Compounds	65-70	sulfotransferase family 1A member 1	Rattus norvegicus	233-239
1293935-2	1992	Thus, 4"-demethylepipodophyllotoxin was reacted with thiols in the presence of BF3.	Sulfhydryl Compounds	53-59	forkhead box C2	Mus musculus	79-82
1311113-5	1992	Mercuric reductase is a FAD-containing oxidoreductase and requires NAD(P)H and thiol for in vitro activity.	Sulfhydryl Compounds	79-84	mercuric reductase	Escherichia coli	0-18
1282970-4	1992	As we have shown that endothelium-derived relaxing factor (EDRF) and other oxides of nitrogen can form adducts with thiols, we hypothesized that EDRF released from normal endothelium S-nitrosates homocysteine, rendering it nontoxic to the endothelium.	Sulfhydryl Compounds	116-122	alpha hemoglobin stabilizing protein	Homo sapiens	22-57
1282970-4	1992	As we have shown that endothelium-derived relaxing factor (EDRF) and other oxides of nitrogen can form adducts with thiols, we hypothesized that EDRF released from normal endothelium S-nitrosates homocysteine, rendering it nontoxic to the endothelium.	Sulfhydryl Compounds	116-122	alpha hemoglobin stabilizing protein	Homo sapiens	59-63
1282970-4	1992	As we have shown that endothelium-derived relaxing factor (EDRF) and other oxides of nitrogen can form adducts with thiols, we hypothesized that EDRF released from normal endothelium S-nitrosates homocysteine, rendering it nontoxic to the endothelium.	Sulfhydryl Compounds	116-122	alpha hemoglobin stabilizing protein	Homo sapiens	145-149
1370350-7	1992	However, CD3-induced signaling was inhibited at N-ethylmaleimide concentrations lower than that required for CD4/pp56lck dissociation, suggesting that CD3-associated tyrosine kinase activity involves acutely sensitive regulatory thiols.	Sulfhydryl Compounds	229-235	CD4 molecule	Homo sapiens	109-112
1816070-1	1991	The Protein disulphide-isomerase (PDI, EC 5.3.4.1, Thiol-proteindisulphide oxidoreductase, EC 1.8.4.2) is thought to regulate the sulfhydryl status of cells and to catalyze thiol/disulphide exchange reactions involved in the post-translational processing of disulphide containing secretory proteins.	Sulfhydryl Compounds	173-178	prolyl 4-hydroxylase subunit beta	Homo sapiens	4-32
1748689-2	1991	RI contains 30 thiol groups, some of which are important for the enzyme-inhibitor interaction.	Sulfhydryl Compounds	15-20	ribonuclease/angiogenin inhibitor 1	Bos taurus	0-2
1761059-6	1991	Dimerization of fibronectin took place most effectively at pH greater than or equal to 8.8 but decreased strongly at lower pH, representing more unfavourable conditions for the action of the thiolate anion in the thiol/disulfide exchange reaction.	Sulfhydryl Compounds	191-196	fibronectin 1	Homo sapiens	16-27
1661291-6	1991	In a cell-free protein C activation assay, homocysteine irreversibly inactivated both thrombomodulin and protein C in a process that required free thiol groups and was inhibited by the oxidizing agents diamide or N-ethylmaleimide.	Sulfhydryl Compounds	147-152	thrombomodulin	Homo sapiens	86-100
1816070-1	1991	The Protein disulphide-isomerase (PDI, EC 5.3.4.1, Thiol-proteindisulphide oxidoreductase, EC 1.8.4.2) is thought to regulate the sulfhydryl status of cells and to catalyze thiol/disulphide exchange reactions involved in the post-translational processing of disulphide containing secretory proteins.	Sulfhydryl Compounds	173-178	prolyl 4-hydroxylase subunit beta	Homo sapiens	34-37
1837513-8	1991	Prostacyclin stimulating factor was reduced in patients with retinopathy (p less than 0.05) and correlated within the plasma with lipid peroxides (r = -0.53, p less than 0.04) and albumin thiols (r = 0.64, p less than 0.01).	Sulfhydryl Compounds	188-194	insulin like growth factor binding protein 7	Homo sapiens	0-31
1666535-6	1991	The data indicate that HOCl-induced contractile dysfunction in heart is related to the inactivation of the SR Ca2+ ATPase as a result of thiol oxidation and suggest that DTT is capable of reversing this dysfunction in situ by reducing the oxidized sulfhydryls in the Ca2+ ATPase.	Sulfhydryl Compounds	137-142	carbonic anhydrase 2	Rattus norvegicus	110-121
1719091-1	1991	Adult T cell leukemia-derived factor (ADF) is a human homologue of thioredoxin with many biologic functions including IL-2R induction, growth promotion, thiol-dependent reducing activity, and radical scavenging activity.	Sulfhydryl Compounds	153-158	thioredoxin	Homo sapiens	38-41
1719091-1	1991	Adult T cell leukemia-derived factor (ADF) is a human homologue of thioredoxin with many biologic functions including IL-2R induction, growth promotion, thiol-dependent reducing activity, and radical scavenging activity.	Sulfhydryl Compounds	153-158	thioredoxin	Homo sapiens	67-78
1657921-3	1991	Chromatography of solubilized hepatic microsomes on Mono Q yielded two peaks, Q-2 and Q-5, which contained all the thiol:protein-disulfide oxidoreductase activity.	Sulfhydryl Compounds	115-120	protein disulfide isomerase family A, member 3	Rattus norvegicus	78-81
1947794-5	1991	Spontaneous dissociation of the complex could be partly avoided by HgCl2, a thiol reagent which inhibits the esterase-like activity of bound C3b.	Sulfhydryl Compounds	76-81	complement C3	Homo sapiens	141-144
1940793-0	1991	Reduction of disulfide bonds during antigen processing: evidence from a thiol-dependent insulin determinant.	Sulfhydryl Compounds	72-77	insulin	Homo sapiens	88-95
1657437-9	1991	We conclude that 1) HOCl caused a rise of [Ca2+]i by inducing the release of Ca2+ from internal stores and impairing cellular extrusion mechanisms and 2) these effects occur through alteration of protein thiol redox status.	Sulfhydryl Compounds	204-209	carbonic anhydrase 2	Oryctolagus cuniculus	43-46
1918082-11	1991	After light chain exchange into myosin, the position of the thiols was mapped by antifluorescyl antibodies in the electron microscope.	Sulfhydryl Compounds	60-66	myosin heavy chain 14	Homo sapiens	32-38
1917974-4	1991	A 40-kDa dipeptide containing the covalent bond was identified by labeling the free thiol group (generated during activation of the internal thioester of C3b) with iodo[1-14C]acetamide and analyzed by amino acid sequencing.	Sulfhydryl Compounds	84-89	complement C3	Homo sapiens	154-157
1898401-1	1991	To clarify the role(s) of thiol (sulfhydryl) groups of cysteine (Cys) residues in the activity of the rat glutathione transferase P (7-7) form (GST-P), a cDNA clone, pGP5, containing the entire coding sequence of GST-P (Y. Sugioka et al., (1985) Nucleic Acids Res.	Sulfhydryl Compounds	26-31	glutathione S-transferase pi 1	Rattus norvegicus	144-149
1798438-0	1991	Evidence for thiol-dependent metallo-endopeptidase involved in degradation of luteinizing hormone-releasing hormone in glioma cells.	Sulfhydryl Compounds	13-18	gonadotropin releasing hormone 1	Homo sapiens	78-115
1655032-8	1991	(6) Low molecular weight thiols and tocopherol protect the microsomal glucose-6-phosphatase against MTAS-induced inhibition.	Sulfhydryl Compounds	25-31	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	70-91
1898401-1	1991	To clarify the role(s) of thiol (sulfhydryl) groups of cysteine (Cys) residues in the activity of the rat glutathione transferase P (7-7) form (GST-P), a cDNA clone, pGP5, containing the entire coding sequence of GST-P (Y. Sugioka et al., (1985) Nucleic Acids Res.	Sulfhydryl Compounds	33-43	glutathione S-transferase pi 1	Rattus norvegicus	144-149
1893995-2	1991	It is suggested that EDRF is a nitrosyl iron complex with low-molecular thiol ligands, most probably with cysteine.	Sulfhydryl Compounds	72-77	alpha hemoglobin stabilizing protein	Homo sapiens	21-25
1804554-7	1991	DTT, a sulfhydryl reducing agent, suppressed both the beta-glucuronidase release and the Ca2+ uptake in CuPh-treated permeable PMNs.	Sulfhydryl Compounds	7-17	glucuronidase beta	Homo sapiens	54-72
1654860-5	1991	It is hypothesized that receptor-mediated transferrin internalization is inhibited by oxidation of critical thiols.	Sulfhydryl Compounds	108-114	transferrin	Homo sapiens	42-53
1898065-7	1991	These results indicate that inactivation of guanidinoacetate methyltransferase by GSSG is the consequence of the formation of a mixed disulfide between a protein thiol and glutathione.	Sulfhydryl Compounds	162-167	guanidinoacetate N-methyltransferase	Rattus norvegicus	44-78
1898401-7	1991	These results suggest that the 47-Cys residue of GST-P may be located near the glutathione binding site, and modulation of this residue by thiol/disulfide exchange may play an important role in regulation of activity.	Sulfhydryl Compounds	139-144	glutathione S-transferase pi 1	Rattus norvegicus	49-54
1716310-5	1991	The ability of the thiol-containing compounds (CPT or NAC) to potentiate the antiaggregatory effects of sodium nitroprusside or iloprost was not associated with an elevation of platelet cyclic GMP or cyclic AMP levels, respectively.	Sulfhydryl Compounds	19-24	X-linked Kx blood group	Homo sapiens	54-57
1883342-9	1991	The inhibited enzyme could be re-activated by addition of 10 mM-2-mercaptoethanol: 60 min after this thiol was added, the inhibited GST-3- activity was bacxk to the control level.	Sulfhydryl Compounds	101-106	glutathione S-transferase pi 1	Homo sapiens	132-137
1716445-5	1991	Pretreatment of methylamine-activated serum or plasma by iodoacetamide substantially decreased the binding of HNP-1 to alpha 2M, suggesting that thiol groups in activated alpha 2M play a role in defensin binding, possibly by covalently trapping defensins via thiol-disulfide exchange.	Sulfhydryl Compounds	145-150	HNP1	Homo sapiens	110-115
1868047-0	1991	Biological thiols elicit prolactin proteolysis by glandular kallikrein and permit regulation by biochemical pathways linked to redox control.	Sulfhydryl Compounds	11-17	prolactin	Rattus norvegicus	25-34
1868106-0	1991	Affinity-chromatographic purification of sixteen cysteine-substituted maltoporin variants: thiol reactivity and cross-linking in an outer membrane protein of Escherichia coli.	Sulfhydryl Compounds	91-96	maltoporin	Escherichia coli	70-80
1716445-5	1991	Pretreatment of methylamine-activated serum or plasma by iodoacetamide substantially decreased the binding of HNP-1 to alpha 2M, suggesting that thiol groups in activated alpha 2M play a role in defensin binding, possibly by covalently trapping defensins via thiol-disulfide exchange.	Sulfhydryl Compounds	145-150	alpha-2-macroglobulin	Homo sapiens	119-127
1716445-5	1991	Pretreatment of methylamine-activated serum or plasma by iodoacetamide substantially decreased the binding of HNP-1 to alpha 2M, suggesting that thiol groups in activated alpha 2M play a role in defensin binding, possibly by covalently trapping defensins via thiol-disulfide exchange.	Sulfhydryl Compounds	145-150	alpha-2-macroglobulin	Homo sapiens	171-179
1651705-4	1991	and optical spectroscopic studies show that the thiol-containing compounds N-(2-mercaptopropionyl) glycine and N-acetylcysteine and the trihydroxamate desferrioxamine attenuate these processes by reducing the ferryl myoglobin species to metmyoglobin, with the formation of thiyl radicals and the desferrioxamine nitroxide radical respectively.	Sulfhydryl Compounds	48-53	myoglobin	Homo sapiens	216-225
1716445-5	1991	Pretreatment of methylamine-activated serum or plasma by iodoacetamide substantially decreased the binding of HNP-1 to alpha 2M, suggesting that thiol groups in activated alpha 2M play a role in defensin binding, possibly by covalently trapping defensins via thiol-disulfide exchange.	Sulfhydryl Compounds	259-264	HNP1	Homo sapiens	110-115
2065060-0	1991	Affinity labeling of the active site and the reactive sulfhydryl associated with activation of rat liver phenylalanine hydroxylase.	Sulfhydryl Compounds	54-64	phenylalanine hydroxylase	Rattus norvegicus	105-130
2065663-5	1991	NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin.	Sulfhydryl Compounds	14-19	nuclear factor kappa B subunit 1	Homo sapiens	61-71
2065663-5	1991	NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin.	Sulfhydryl Compounds	14-19	tumor necrosis factor	Homo sapiens	130-139
2065663-5	1991	NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double-stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1, lipopolysaccharide and lectin.	Sulfhydryl Compounds	14-19	interleukin 1 alpha	Homo sapiens	163-176
1872813-11	1991	Thiol reagents and metal chelators strongly inhibited the hydrolysis of both Ox-Hb and insulin, whereas inhibitors of serine, aspartic and thiol proteases had little effect.	Sulfhydryl Compounds	0-5	insulin	Oryctolagus cuniculus	77-94
1867634-3	1991	p31 was also synthesized in response to the thiol-reactive agent diethylmaleate and heavy metal sodium arsenite but not to high temperature treatment, platelet-derived growth factor, and 12-O-tetradecanoylphorbol 13-acetate.	Sulfhydryl Compounds	44-49	ATPase H+ transporting V1 subunit E1	Rattus norvegicus	0-3
1778302-6	1991	In contrast, hFSH-beta-(33-53), a thiol-containing peptide which corresponds to a second FSH receptor-binding domain but lacks the sequence similar to the thioredoxin active center, was inactive.	Sulfhydryl Compounds	34-39	follicle stimulating hormone subunit beta	Homo sapiens	13-22
1906943-3	1991	Optimum conditions for the cerebellar AChE activity were determined with respect to molarity of the buffer, pH, temperature, and concentrations of substrate (acetylthiocholine iodide), activators (NaCl, MgCl2), and thiol indicator (dithiobisnitrobenzoic acid).	Sulfhydryl Compounds	215-220	acetylcholinesterase (Cartwright blood group)	Homo sapiens	38-42
2039457-0	1991	Oxidation of thiol in the vimentin cytoskeleton.	Sulfhydryl Compounds	13-18	vimentin	Homo sapiens	26-34
1646599-6	1991	In addition, a cysteine residue of p20 is located near the haemopexin-binding site, since haemopexin, which has no free thiol groups, is cross-linked to this subunit by the hetero-bifunctional agent sulpho-SMPB.	Sulfhydryl Compounds	120-125	demilune cell and parotid protein 1	Mus musculus	35-38
1646033-2	1991	Xanthine plus xanthine oxidase (X + XO) which is known to generate superoxide anions (O2-) and hydrogen peroxide (H2O2), an activated species of oxygen, was found to decrease Ca(2+)-stimulated ATPase activity, increase Mg(2+)-ATPase activity and reduce sulfhydryl (SH) group contents in myofibrils; these effects were completely prevented by superoxide dismutase (SOD) plus catalase (CAT).	Sulfhydryl Compounds	253-263	catalase	Rattus norvegicus	374-382
1646033-2	1991	Xanthine plus xanthine oxidase (X + XO) which is known to generate superoxide anions (O2-) and hydrogen peroxide (H2O2), an activated species of oxygen, was found to decrease Ca(2+)-stimulated ATPase activity, increase Mg(2+)-ATPase activity and reduce sulfhydryl (SH) group contents in myofibrils; these effects were completely prevented by superoxide dismutase (SOD) plus catalase (CAT).	Sulfhydryl Compounds	253-263	catalase	Rattus norvegicus	384-387
1850188-3	1991	Furthermore, the beneficial effects of ACE inhibitors that contain a sulfhydryl group may be due in part to the ability of thiol compounds to act as nonspecific antioxidants or direct scavengers of cytotoxic oxygen-derived free radicals.	Sulfhydryl Compounds	123-128	angiotensin I converting enzyme	Canis lupus familiaris	39-42
1850188-4	1991	To investigate this question we compared the effects of (1) the sulfhydryl-containing ACE inhibitor zofenopril, (2) the sulfhydryl-containing stereoisomer of captopril (SQ 14,534) with essentially no ACE inhibitor properties, (3) the nonsulfhydryl-containing ACE inhibitor enalaprilat, and (4) solvent alone, given at the time of reperfusion, on recovery of contractile function after 15 minutes of coronary occlusion in the anesthetized open-chest dog.	Sulfhydryl Compounds	64-74	angiotensin I converting enzyme	Canis lupus familiaris	86-89
1904276-8	1991	TFEC metabolites were very reactive with the thiol nucleophiles glutathione and N-acetylcysteine.	Sulfhydryl Compounds	45-50	transcription factor EC	Homo sapiens	0-4
2039457-3	1991	Vimentin thiol is oxidized in preference to other cytoskeleton proteins.	Sulfhydryl Compounds	9-14	vimentin	Homo sapiens	0-8
2039457-4	1991	Immunoblot analysis also demonstrated a loss of reactivity to an anti-vimentin monoclonal antibody under non-reducing conditions, possibly due to thiol-group oxidation.	Sulfhydryl Compounds	146-151	vimentin	Homo sapiens	70-78
1708376-9	1991	The amino acid sequence of the protein has similarity to bovine liver rhodanese, an enzyme that transfers the thiol group of thiosulfate to a thiophilic acceptor molecule, and a rhodaneselike protein of Saccharopolyspora erythraea.	Sulfhydryl Compounds	110-115	thiosulfate sulfurtransferase	Bos taurus	70-79
2016307-2	1991	Fluorescence resonance energy transfer was used to monitor aggregation kinetics of the "thiol-activated" cytolysin (perfringolysin O (PFO) or theta-toxin) of Clostridium perfringens on erythrocyte membranes.	Sulfhydryl Compounds	88-93	perforin 1	Homo sapiens	105-114
2025220-2	1991	The number of reactive thiol groups in mammalian liver protein disulphide-isomerase (PDI) in various conditions was investigated by alkylation with iodo[14C]acetate.	Sulfhydryl Compounds	23-28	prolyl 4-hydroxylase subunit beta	Homo sapiens	55-83
2025220-2	1991	The number of reactive thiol groups in mammalian liver protein disulphide-isomerase (PDI) in various conditions was investigated by alkylation with iodo[14C]acetate.	Sulfhydryl Compounds	23-28	prolyl 4-hydroxylase subunit beta	Homo sapiens	85-88
2025220-12	1991	The activity of PDI in thiol/disulphide interchange derives from the presence of vicinal dithiol groups in which one thiol group of each pair has an unusually low pK and high nucleophilic reactivity at physiological pH.	Sulfhydryl Compounds	23-28	prolyl 4-hydroxylase subunit beta	Homo sapiens	16-19
2025220-12	1991	The activity of PDI in thiol/disulphide interchange derives from the presence of vicinal dithiol groups in which one thiol group of each pair has an unusually low pK and high nucleophilic reactivity at physiological pH.	Sulfhydryl Compounds	91-96	prolyl 4-hydroxylase subunit beta	Homo sapiens	16-19
1656405-7	1991	Thiol groups in the neurotensin receptors may be important for the receptor function.	Sulfhydryl Compounds	0-5	neurotensin	Canis lupus familiaris	20-31
1874890-2	1991	Prior to reversed-phase HPLC analysis, the serum thiols were derivatized with SBD-F (ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate), a thiolspecific fluorogenic probe which is commercially available.	Sulfhydryl Compounds	49-55	OXA1L mitochondrial inner membrane protein	Homo sapiens	110-115
1849899-6	1991	We propose that iodoacetamide acts to alkylate some unknown thiols released during tissue homogenization and that in its absence these thiols formed mixed disulfides with the insulin receptor, thus adversely affecting the process of receptor activation by insulin.	Sulfhydryl Compounds	135-141	insulin receptor	Rattus norvegicus	175-191
1854455-1	1991	The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents.	Sulfhydryl Compounds	160-165	angiotensinogen	Rattus norvegicus	49-63
2007598-14	1991	Although this result is in accord with the finding that, in mammalian cells, the thiol groups of histone H3 become accessible when nucleosomes "unfold" during transcription, we find that nucleosomes containing the GAL1 DNA sequences of the yeast H3-mutant also bind to the mercury column when that gene is not being expressed.	Sulfhydryl Compounds	81-86	galectin 1	Homo sapiens	214-218
1854455-1	1991	The possibility of receptor heterogeneity in the angiotensin II (AII) system has been suggested previously, based on differences in Kd values or sensitivity to thiol reagents.	Sulfhydryl Compounds	160-165	angiotensinogen	Rattus norvegicus	65-68
1990978-5	1991	Treatment of IREC with the glutathione reductase inhibitor, 1,3-bis(2-chloroethyl)-1-nitrosourea, potentiated the thiol depletion and toxicity observed with menadione and M(NAC)NQ indicating the involvement of oxidative stress in this model of renal cell toxicity.	Sulfhydryl Compounds	114-119	glutathione-disulfide reductase	Rattus norvegicus	27-48
2049244-2	1991	The currently available evidence shows that thiol containing ACE inhibitors are free radical (FR) scavengers in vitro; in particular the OH.	Sulfhydryl Compounds	44-49	angiotensin I converting enzyme	Homo sapiens	61-64
1883398-0	1991	Fluorescence changes of 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole bound to thiol groups of gizzard myosin.	Sulfhydryl Compounds	73-78	OXA1L mitochondrial inner membrane protein	Homo sapiens	48-53
1674275-0	1991	Rates for repair of pBR 322 DNA radicals by thiols as measured by the gas explosion technique: evidence that counter-ion condensation and co-ion depletion are significant at physiological ionic strength.	Sulfhydryl Compounds	44-50	translocator protein	Homo sapiens	20-23
1674275-1	1991	Rates of repair of pBR 322 plasmid DNA radicals by thiols of varying net charge (Z) at pH 7 and physiological ionic strength were measured using the oxygen explosion technique.	Sulfhydryl Compounds	51-57	translocator protein	Homo sapiens	19-22
2012597-6	1991	Increasing levels of thiol reduction resulted in progressive loss of disulphide bonds, release of the 118 kDa glycoprotein and depolymerization of the mucin.	Sulfhydryl Compounds	21-26	solute carrier family 13 member 2	Rattus norvegicus	151-156
2002060-0	1991	Reversible inhibition of neutrophil elastase by thiol-modified alpha-1 protease inhibitor.	Sulfhydryl Compounds	48-53	elastase, neutrophil expressed	Homo sapiens	25-44
2002060-0	1991	Reversible inhibition of neutrophil elastase by thiol-modified alpha-1 protease inhibitor.	Sulfhydryl Compounds	48-53	serpin family A member 1	Homo sapiens	63-89
2002060-2	1991	Whereas native alpha 1-PI combines rapidly and quasi-irreversibly with neutrophil elastase, the thiol-modified alpha 1-PI derivatives are dissociable reversible competitive inhibitors of the enzyme, with values of Ki in the range of 6-7 nM.	Sulfhydryl Compounds	96-101	serpin family A member 1	Homo sapiens	111-121
2002060-4	1991	Once native alpha 1-PI has combined with neutrophil elastase, the enzyme-inhibitor complex retains a reactive thiol group, but the two proteins can no longer be dissociated by subsequent reaction with ANM, even after exposure to sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Sulfhydryl Compounds	110-115	serpin family A member 1	Homo sapiens	12-22
1705826-9	1991	Titration of thiol groups [with 5,5"-dithiobis(2-nitrobenzoic acid)] and the effect of dithiothreitol on Km for PRib-PP indicate that oxidation of thiol groups occurs on storage of HPRT, even in the presence of 1 mM beta-mercaptoethanol.	Sulfhydryl Compounds	147-152	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	181-185
1996987-1	1991	We have examined the influence of sulfhydryl (SH)-group modifying agents on the interaction of the rat liver glucocorticoid receptor (GR) with its known agonist triamcinolone acetonide (TA) and the newly synthesized antagonist mifepristone (RU486).	Sulfhydryl Compounds	34-44	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	109-132
1996987-1	1991	We have examined the influence of sulfhydryl (SH)-group modifying agents on the interaction of the rat liver glucocorticoid receptor (GR) with its known agonist triamcinolone acetonide (TA) and the newly synthesized antagonist mifepristone (RU486).	Sulfhydryl Compounds	34-44	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	134-136
1996987-1	1991	We have examined the influence of sulfhydryl (SH)-group modifying agents on the interaction of the rat liver glucocorticoid receptor (GR) with its known agonist triamcinolone acetonide (TA) and the newly synthesized antagonist mifepristone (RU486).	Sulfhydryl Compounds	46-48	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	109-132
1996987-1	1991	We have examined the influence of sulfhydryl (SH)-group modifying agents on the interaction of the rat liver glucocorticoid receptor (GR) with its known agonist triamcinolone acetonide (TA) and the newly synthesized antagonist mifepristone (RU486).	Sulfhydryl Compounds	46-48	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	134-136
1986799-7	1991	Reactions of PZP-thiol groups do not give rise to fluorescence changes.	Sulfhydryl Compounds	17-22	PZP alpha-2-macroglobulin like	Homo sapiens	13-16
2017301-5	1991	The initial cleavage of LHRH, as determined by following the loss of the LHRH peak, was strongly inhibited by thiol-blocking reagents, as well as metal chelators.	Sulfhydryl Compounds	110-115	gonadotropin releasing hormone 1	Rattus norvegicus	24-28
2017301-5	1991	The initial cleavage of LHRH, as determined by following the loss of the LHRH peak, was strongly inhibited by thiol-blocking reagents, as well as metal chelators.	Sulfhydryl Compounds	110-115	gonadotropin releasing hormone 1	Rattus norvegicus	73-77
2017301-7	1991	Thus, we propose that a thiol-dependent membrane-bound metallo-endopeptidase plays a major role in the initial stage of degradation of LHRH at the Tyr5-Gly6 bond in both neurons and glia.	Sulfhydryl Compounds	24-29	gonadotropin releasing hormone 1	Rattus norvegicus	135-139
1676681-3	1991	The modification of free SH groups by thiol-reactive agents had only a minor effect on ANF binding or on the extent of ANF-dependent enzyme stimulation whereas free thiol groups were essential for basal enzyme activity of ANF-sensitive particulate guanylate cyclase.	Sulfhydryl Compounds	165-170	guanylate cyclase	Bos taurus	248-265
2090118-0	1990	[Use of thiol sorbents for obtaining human recombinant proinsulin].	Sulfhydryl Compounds	8-13	insulin	Homo sapiens	55-65
1801722-4	1991	However, urine contains thiol activatable proteinases causing substrate hydrolysis, which is to a varying extent inhibited by E-64 or Z-Phe-Phe-CHN2.	Sulfhydryl Compounds	24-29	chimerin 2	Homo sapiens	144-148
1707847-0	1991	Spin-trapping studies of the oxidation-reduction reactions of iron bleomycin in the presence of thiols and buffer.	Sulfhydryl Compounds	96-102	spindlin 1	Homo sapiens	0-4
2174432-8	1990	Dialysis of aldose reductase in the absence of thiols or NADP converts it into a form that shows markedly different kinetic properties, including very weak catalytic activity toward glucose and insensitivity to aldose reductase inhibitors.	Sulfhydryl Compounds	47-53	aldo-keto reductase family 1 member B	Homo sapiens	12-28
2174432-10	1990	Thiol titration of the two forms of aldose reductase with Ellman"s reagent indicated that two thiol groups were lost when the enzyme was dialyzed in the absence of dithiothreitol or NADP.	Sulfhydryl Compounds	0-5	aldo-keto reductase family 1 member B	Homo sapiens	36-52
2174432-10	1990	Thiol titration of the two forms of aldose reductase with Ellman"s reagent indicated that two thiol groups were lost when the enzyme was dialyzed in the absence of dithiothreitol or NADP.	Sulfhydryl Compounds	94-99	aldo-keto reductase family 1 member B	Homo sapiens	36-52
1801517-1	1991	Different from other proteases the halide- and thiol-dependent lysosomal dipeptidyl peptidase I (DPP I, cathepsin C, EC 3.4.14.1.)	Sulfhydryl Compounds	47-52	cathepsin C	Rattus norvegicus	73-95
1801517-1	1991	Different from other proteases the halide- and thiol-dependent lysosomal dipeptidyl peptidase I (DPP I, cathepsin C, EC 3.4.14.1.)	Sulfhydryl Compounds	47-52	cathepsin C	Rattus norvegicus	97-102
1801517-1	1991	Different from other proteases the halide- and thiol-dependent lysosomal dipeptidyl peptidase I (DPP I, cathepsin C, EC 3.4.14.1.)	Sulfhydryl Compounds	47-52	cathepsin C	Rattus norvegicus	104-115
2267665-7	1990	The present study suggests that monocrotophos and its thiol analogues may bring about physiological upsets by altering GSH and GST dependent events in different tissues of exposed organisms.	Sulfhydryl Compounds	54-59	hematopoietic prostaglandin D synthase	Rattus norvegicus	127-130
2253599-12	1990	Incubation of ALAD in vitro with gallium and lead, an active thiol group inhibitor, resulted in a greater inhibition of the enzyme.	Sulfhydryl Compounds	61-66	aminolevulinate dehydratase	Rattus norvegicus	14-18
2241155-0	1990	Studies on the interaction of a thiol-dependent hydrogen peroxide scavenging enzyme and phenylalanine hydroxylase.	Sulfhydryl Compounds	32-37	phenylalanine hydroxylase	Rattus norvegicus	88-113
2148273-5	1990	These results suggest that the covalent modification at the specific sulfhydryl residues in sarcoplasmic reticulum ATPase may mark the enzyme for degradation by intracellular proteinases, such as calpain.	Sulfhydryl Compounds	69-79	calpain 1	Gallus gallus	196-203
2146921-8	1990	(iv) Sulfhydryl reducing agents (e.g., dithiothreitol, DTT, 1-5 mM) inhibited RDS-induced Ca2+ efflux in a concentration-dependent manner.	Sulfhydryl Compounds	5-15	peripherin 2	Canis lupus familiaris	78-81
2084182-3	1990	In the present study, the effects of inducers of mixed-function oxidase (MFO) and non-protein sulfhydryl (NPSH) depletor on the total and covalent binding of [14C]-CAT radioactivity to liver and kidney of the starling were examined.	Sulfhydryl Compounds	94-104	catalase	Sturnus vulgaris	164-167
1700994-7	1990	In each instance, alpha M-IL-1 beta complex formation was observed only after treatment of alpha M with methylamine, a primary amine that causes cleavage of the internal thiol ester in alpha M and the appearance of free thiol groups.	Sulfhydryl Compounds	170-175	interleukin 1 beta	Homo sapiens	26-35
2261144-9	1990	The prototype orally active ACE inhibitor, captopril, is a sulfhydryl compound with a good safety profile at the recommended dosages but reported toxicity at higher dosages.	Sulfhydryl Compounds	59-69	angiotensin I converting enzyme	Homo sapiens	28-31
2171674-7	1990	The results of additional experiments using erythrocyte lysate and of kinetic experiments on solutions containing PSSG and/or GSH, NADPH and glutathione reductase suggest that the predominant mechanism for reduction of PSSG is by a thiol-disulfide exchange reaction with GSH to form PSH and GSSG, which in turn undergoes enzyme-catalyzed reduction by NADPH.	Sulfhydryl Compounds	232-237	2,4-dienoyl-CoA reductase 1	Homo sapiens	131-136
1706443-1	1990	Response of murine lymphnode cells (LNC) sensitized with sulfhydryl drugs to recombinant interleukin 2 (rIL-2) was studied in antigen-specific lymphocyte proliferation test (LPT).	Sulfhydryl Compounds	57-67	interleukin 2	Mus musculus	89-102
1706443-1	1990	Response of murine lymphnode cells (LNC) sensitized with sulfhydryl drugs to recombinant interleukin 2 (rIL-2) was studied in antigen-specific lymphocyte proliferation test (LPT).	Sulfhydryl Compounds	57-67	interleukin 2	Rattus norvegicus	104-109
2173595-9	1990	These data suggest that alkylation of a sulfhydryl-moiety in the IP3-receptor molecule causes inactivation of the receptor function.	Sulfhydryl Compounds	40-50	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	65-77
2171674-7	1990	The results of additional experiments using erythrocyte lysate and of kinetic experiments on solutions containing PSSG and/or GSH, NADPH and glutathione reductase suggest that the predominant mechanism for reduction of PSSG is by a thiol-disulfide exchange reaction with GSH to form PSH and GSSG, which in turn undergoes enzyme-catalyzed reduction by NADPH.	Sulfhydryl Compounds	232-237	glutathione-disulfide reductase	Homo sapiens	141-162
2171674-7	1990	The results of additional experiments using erythrocyte lysate and of kinetic experiments on solutions containing PSSG and/or GSH, NADPH and glutathione reductase suggest that the predominant mechanism for reduction of PSSG is by a thiol-disulfide exchange reaction with GSH to form PSH and GSSG, which in turn undergoes enzyme-catalyzed reduction by NADPH.	Sulfhydryl Compounds	232-237	2,4-dienoyl-CoA reductase 1	Homo sapiens	351-356
2171356-5	1990	The stimulation by the diuretic was prevented and reversed by thiols such as cysteine and dithiothreitol, which also prevented and reversed the stimulation of renin secretion by the nondiuretic sulfhydryl reagent P-chloromercuriphenyl-sulfonate (PCMPS).	Sulfhydryl Compounds	62-68	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	159-164
2241916-0	1990	Sensitivity of system A and ASC transport activities to thiol-group-modifying reagents in rat liver plasma-membrane vesicles.	Sulfhydryl Compounds	56-61	PYD and CARD domain containing	Rattus norvegicus	28-31
2241916-3	1990	In the present study we have examined the sensitivity of A and ASC amino-acid-carrier activities in rat liver plasma-membrane vesicles to the thiol-group modifying reagents N-ethylmaleimide (NEM) and iodoacetamide (IA).	Sulfhydryl Compounds	142-147	PYD and CARD domain containing	Rattus norvegicus	63-66
2241916-19	1990	It is concluded that there is one, or several, free thiol groups in A and ASC carriers, the integrity of which is essential for transport activity.	Sulfhydryl Compounds	52-57	PYD and CARD domain containing	Rattus norvegicus	74-77
2241916-20	1990	Sensitivity to thiol-group-specific reagents and the pattern of protection with substrates against inactivation is different in A and ASC carriers.	Sulfhydryl Compounds	15-20	PYD and CARD domain containing	Rattus norvegicus	134-137
2241916-21	1990	That suggests the existence of topological dissimilarities regarding the thiol-group containing site(s) in A and ASC amino acid carriers.	Sulfhydryl Compounds	73-78	PYD and CARD domain containing	Rattus norvegicus	113-116
2211666-0	1990	Free thiols of platelet thrombospondin.	Sulfhydryl Compounds	5-11	thrombospondin 1	Homo sapiens	24-38
2211666-2	1990	The free thiols of platelet thrombospondin (TSP) were derivatized with labeled N-ethylmaleimide (NEM) or iodoacetamide (IAM).	Sulfhydryl Compounds	9-15	thrombospondin 1	Homo sapiens	28-42
2211666-2	1990	The free thiols of platelet thrombospondin (TSP) were derivatized with labeled N-ethylmaleimide (NEM) or iodoacetamide (IAM).	Sulfhydryl Compounds	9-15	thrombospondin 1	Homo sapiens	44-47
2211666-5	1990	Since TSP has three apparently identical polypeptide chains, this suggests one free thiol/polypeptide chain.	Sulfhydryl Compounds	84-89	thrombospondin 1	Homo sapiens	6-9
2211666-7	1990	In Ca2+ about half the thiols reacted normally with NEM and the others were unreactive, indicating that the thiols of TSP are not identical.	Sulfhydryl Compounds	108-114	thrombospondin 1	Homo sapiens	118-121
2398350-1	1990	Disulfide-bridged S100b protein formation, aircatalyzed and induced by thiol/disulfide exchange, was studied under various ionic conditions.	Sulfhydryl Compounds	71-76	S100 calcium binding protein B	Homo sapiens	18-23
1965778-5	1990	With leucinthiol-enkephalin in biological assays which examine its inhibitory activity for electrically stimulated contractions of isolated smooth muscle, it was found that the reactive thiol group exists in the mu receptors present in the guinea pig ileum.	Sulfhydryl Compounds	11-16	proenkephalin	Rattus norvegicus	17-27
1965778-6	1990	Leucinthiol-enkephalin became bound covalently to this receptor-thiol group via disulfide formation after prolonged incubation.	Sulfhydryl Compounds	6-11	proenkephalin	Rattus norvegicus	12-22
2079029-0	1990	Two-dimensional electrophoresis of the fatty acid binding protein from human heart: evidence for a thiol group which can form an intermolecular disulfide bond.	Sulfhydryl Compounds	99-104	glutamic-oxaloacetic transaminase 2	Homo sapiens	39-65
2394726-6	1990	These results suggest that thioltransferase and PDI contribute to the regeneration of oxidized ascorbic acid in mammalian cells, and based on their cellular location, thioltransferase is proposed to be the major cytoplasmic activity, whereas interaction of DHA with microsomal membrane PDI may catalyze regeneration of ascorbic acid and initiate oxidation of intralumenal protein thiols to disulfides.	Sulfhydryl Compounds	380-386	glutaredoxin	Homo sapiens	27-43
2398057-9	1990	Sulfhydryl analysis of purified cytochrome b561 showed that all 3 cysteine residues were in the free sulfhydryl form.	Sulfhydryl Compounds	101-111	cytochrome b561	Homo sapiens	32-47
2203779-7	1990	This result would rather support the hypothesis of thioredoxin playing the role of a thiol carrier in the reduction of PAPS into sulfite.	Sulfhydryl Compounds	85-90	thioredoxin	Homo sapiens	51-62
2394726-6	1990	These results suggest that thioltransferase and PDI contribute to the regeneration of oxidized ascorbic acid in mammalian cells, and based on their cellular location, thioltransferase is proposed to be the major cytoplasmic activity, whereas interaction of DHA with microsomal membrane PDI may catalyze regeneration of ascorbic acid and initiate oxidation of intralumenal protein thiols to disulfides.	Sulfhydryl Compounds	380-386	prolyl 4-hydroxylase subunit beta	Homo sapiens	48-51
2394726-6	1990	These results suggest that thioltransferase and PDI contribute to the regeneration of oxidized ascorbic acid in mammalian cells, and based on their cellular location, thioltransferase is proposed to be the major cytoplasmic activity, whereas interaction of DHA with microsomal membrane PDI may catalyze regeneration of ascorbic acid and initiate oxidation of intralumenal protein thiols to disulfides.	Sulfhydryl Compounds	380-386	glutaredoxin	Homo sapiens	167-183
2116409-8	1990	Both TFIIIA and the 7 S particle were reacted with the thiol-specific fluorescent probe N-iodoacetyl-N"-(5-sulfo-1-naphthyl)ethylenediamine (1,5-I-AEDANS).	Sulfhydryl Compounds	55-60	general transcription factor 3A L homeolog	Xenopus laevis	5-11
1980817-5	1990	The finding that the carbon analogue 11 (two methylenes for the disulfide bridge) was devoid of activity is consistent with the hypothesis that histamine H2-receptor inhibition is the result of a covalent bond formation by a way of a disulfide-thiol interchange reaction between the disulfide moiety of tetraamine disulfides and a receptor thiol group.	Sulfhydryl Compounds	244-249	histamine receptor H2	Homo sapiens	144-165
1980817-5	1990	The finding that the carbon analogue 11 (two methylenes for the disulfide bridge) was devoid of activity is consistent with the hypothesis that histamine H2-receptor inhibition is the result of a covalent bond formation by a way of a disulfide-thiol interchange reaction between the disulfide moiety of tetraamine disulfides and a receptor thiol group.	Sulfhydryl Compounds	340-345	histamine receptor H2	Homo sapiens	144-165
2120461-10	1990	The toxicity of MCLR may be related to alterations in the sulfhydryl content of the cytoskeletal protein.	Sulfhydryl Compounds	58-68	adducin 3 (gamma)	Mus musculus	84-104
2143367-0	1990	Reaction of thiol groups of gizzard myosin heavy chains with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole.	Sulfhydryl Compounds	12-17	myosin, heavy chain 15	Gallus gallus	36-42
2376587-7	1990	Quantitation of DCIP reduction by MPT of Mo fragment of sulfite oxidase showed a two-electron oxidation of MPT, even when the Mo fragment was denatured in the presence of Hg2+ to prevent internal reduction reactions due to sulfhydryls or sulfide.	Sulfhydryl Compounds	223-234	sulfite oxidase	Rattus norvegicus	56-71
2143367-8	1990	The reagent NBD-Cl can detect changes in the conformation of gizzard myosin by way of its reaction with thiol groups of the heavy chain region.	Sulfhydryl Compounds	104-109	myosin, heavy chain 15	Gallus gallus	69-75
2223772-4	1990	Thiol titration of ALBP with DTNB in the presence of bound oleate resulted in the modification of a single cysteinyl residue.	Sulfhydryl Compounds	0-5	fatty acid binding protein 4	Homo sapiens	19-23
2378896-1	1990	Biliverdin reductase (molecular form 1, EC 1.3.1.24, bilirubin:NAD(P)+ oxidoreductase) carries three thiol residues.	Sulfhydryl Compounds	101-106	thioredoxin reductase 1	Homo sapiens	71-85
2364441-3	1990	Stimulation of macrophages with bacterial lipopolysaccharide (LPS) or tumor necrosis factor (TNF) strongly augments the amount of thiol released into the culture supernatant.	Sulfhydryl Compounds	130-135	tumor necrosis factor	Ovis aries	70-91
2364441-3	1990	Stimulation of macrophages with bacterial lipopolysaccharide (LPS) or tumor necrosis factor (TNF) strongly augments the amount of thiol released into the culture supernatant.	Sulfhydryl Compounds	130-135	tumor necrosis factor	Ovis aries	93-96
2177163-0	1990	Thiol-dependent membrane-bound metallo-endopeptidase functioning in degradation of luteinizing hormone-releasing hormone in neuroblastoma cells and rat brain synaptic membrane.	Sulfhydryl Compounds	0-5	gonadotropin releasing hormone 1	Rattus norvegicus	83-120
2209681-3	1990	During iodination, I+ and I2 oxidize these sulfhydryls to produce disulfide-linked C1q aggregates.	Sulfhydryl Compounds	43-54	complement C1q A chain	Homo sapiens	83-86
2394940-2	1990	When added to the assay mix, as little as 0.5 mmol/L acetaldehyde competitively inhibited ALAD even in the presence of dithiothreitol, a sulfhydryl reagent.	Sulfhydryl Compounds	137-147	aminolevulinate dehydratase	Rattus norvegicus	90-94
2375757-20	1990	Furthermore, the GSTs appear to be very critical with respect to a correct orientation of the thiol group of the GSH analogue.	Sulfhydryl Compounds	94-99	glutathione S-transferase mu 1	Rattus norvegicus	17-21
1698474-5	1990	Using eosin attached to the SH-1 thiol of the myosin head differing rotational modes of the bound probe were detected, dependent upon excitation wavelength.	Sulfhydryl Compounds	33-38	myosin heavy chain 14	Homo sapiens	46-52
1694878-0	1990	Different roles for thiol and aspartyl proteases in antigen presentation of ovalbumin.	Sulfhydryl Compounds	20-25	ovalbumin (SERPINB14)	Gallus gallus	76-85
2215357-6	1990	2-D maps derived from CNBr peptides of keloid collagen demonstrated thiol reduction sensitive alpha 1(III)-CB9 dimer as well as 24,000- and 32,000-dalton CNBr peptides, which were not mercaptoethanol reduction sensitive in normal skin due to cross-linking via the lysyl oxidase pathway.	Sulfhydryl Compounds	68-73	adrenoceptor alpha 1D	Homo sapiens	94-110
1693530-10	1990	Treatment of purified plasma alpha 2M and C3 with trypsin or activation with methylamine, which causes cleavage of the internal thiol ester and the appearance of free thiol groups in these proteins, mediated binding of 125I-IL-1 beta to alpha 2M and C3b.	Sulfhydryl Compounds	128-133	alpha-2-macroglobulin	Mus musculus	29-37
1982017-2	1990	Thiol derivatives of glutamate and aspartate in which the alpha-COOH group was replaced by -CH2SH were synthesized as inhibitors of glutamyl aminopeptidase.	Sulfhydryl Compounds	0-5	glutamyl aminopeptidase	Homo sapiens	132-155
1982017-3	1990	Glutamate thiol was a potent inhibitor of glutamyl aminopeptidase (Ki = 4 x 10(-7) M) but even more potently inhibited microsomal alanyl aminopeptidase (Ki = 2.5 x 10(-7) M).	Sulfhydryl Compounds	10-15	glutamyl aminopeptidase	Homo sapiens	42-65
1982017-4	1990	Aspartate thiol (beta-homocysteine) was a less potent but more selective inhibitor of glutamyl aminopeptidase (glutamyl aminopeptidase: Ki = 1.2 x 10(-6) M; microsomal alanyl aminopeptidase: Ki = 7.5 x 10(-6) M).	Sulfhydryl Compounds	10-15	glutamyl aminopeptidase	Homo sapiens	86-109
1982017-4	1990	Aspartate thiol (beta-homocysteine) was a less potent but more selective inhibitor of glutamyl aminopeptidase (glutamyl aminopeptidase: Ki = 1.2 x 10(-6) M; microsomal alanyl aminopeptidase: Ki = 7.5 x 10(-6) M).	Sulfhydryl Compounds	10-15	glutamyl aminopeptidase	Homo sapiens	111-134
2357215-8	1990	Based on these results, we propose that GS-Cbl or a closely related thiol-cobalamin adduct is a proximal precursor in cobalamin coenzyme biosynthesis.	Sulfhydryl Compounds	68-73	E3 ubiquitin-protein ligase CBL	Oryctolagus cuniculus	43-46
2194451-4	1990	With the use of an appropriate thiol concentration, scrambling of the native disulphide bonds in bovine insulin occurs, and the process is catalysed by protein disulphide-isomerase (EC 5.3.4.1).	Sulfhydryl Compounds	31-36	insulin	Bos taurus	104-111
1693530-10	1990	Treatment of purified plasma alpha 2M and C3 with trypsin or activation with methylamine, which causes cleavage of the internal thiol ester and the appearance of free thiol groups in these proteins, mediated binding of 125I-IL-1 beta to alpha 2M and C3b.	Sulfhydryl Compounds	128-133	interleukin 1 beta	Mus musculus	224-233
1693530-11	1990	The results suggest that cleavage of the internal thiol ester in C3 and alpha 2M makes these plasma proteins susceptible to binding of 125I-IL-1 beta and that free thiol groups do play a role in the formation of 125I-IL-1 beta plasma protein complexes.	Sulfhydryl Compounds	50-55	alpha-2-macroglobulin	Mus musculus	72-80
1693530-11	1990	The results suggest that cleavage of the internal thiol ester in C3 and alpha 2M makes these plasma proteins susceptible to binding of 125I-IL-1 beta and that free thiol groups do play a role in the formation of 125I-IL-1 beta plasma protein complexes.	Sulfhydryl Compounds	50-55	interleukin 1 beta	Mus musculus	140-149
2359068-1	1990	Captopril, which is a thiol containing angiotensin converting enzyme (ACE) inhibitor that has a close structural similarity to D-penicillamine, behaves as a disease modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA).	Sulfhydryl Compounds	22-27	angiotensin I converting enzyme	Homo sapiens	39-68
2380743-7	1990	Generally, the effects of LMS on CTLL-2 growth were quite similar to those of structurally unrelated compounds known to have antioxidant properties, and the demonstrated thiol requirement of this cell line for growth in recombinant IL-2 was met by substituting LMS for 2-ME.	Sulfhydryl Compounds	170-175	interleukin 2	Mus musculus	232-236
2188439-4	1990	Captopril, the first orally active, commercially available ACE inhibitor, is a sulfhydryl-containing compound.	Sulfhydryl Compounds	79-89	angiotensin I converting enzyme	Homo sapiens	59-62
2360207-12	1990	These findings indicate that the reactive thiol moiety formed by cysteine conjugate beta-lyase cleavage of PCBC can inhibit both glutathione reductase and lipoyl dehydrogenase activities in vivo following HCBD administration.	Sulfhydryl Compounds	42-47	glutathione-disulfide reductase	Rattus norvegicus	129-150
2160452-3	1990	The single cysteine residue in Ub-C48 can be converted into a lysine analog by modification with the sulfhydryl-specific reagent, aminoethyl-8 (N-(iodoethyl)trifluoroacetamide).	Sulfhydryl Compounds	101-111	CDK5 regulatory subunit associated protein 2	Homo sapiens	34-37
2359068-1	1990	Captopril, which is a thiol containing angiotensin converting enzyme (ACE) inhibitor that has a close structural similarity to D-penicillamine, behaves as a disease modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA).	Sulfhydryl Compounds	22-27	angiotensin I converting enzyme	Homo sapiens	70-73
2371919-8	1990	It is concluded that both thiol- and disulphide moieties play important roles in the regulation of histamine H1-receptor activity.	Sulfhydryl Compounds	26-31	histamine H1 receptor	Cavia porcellus	99-120
2340265-2	1990	The rate constant for the reaction of the thiolate of 2-mercaptoethanol with NEM is 10(7) M-1 min-1, whereas the rate constant for the reaction of the protonated thiol is less than 0.0002 M-1 min-1.	Sulfhydryl Compounds	42-47	myoregulin	Homo sapiens	90-99
2340265-2	1990	The rate constant for the reaction of the thiolate of 2-mercaptoethanol with NEM is 10(7) M-1 min-1, whereas the rate constant for the reaction of the protonated thiol is less than 0.0002 M-1 min-1.	Sulfhydryl Compounds	42-47	myoregulin	Homo sapiens	188-197
2185743-0	1990	Thiol-dependent metallo-endopeptidase characteristics of Pz-peptidase in rat and rabbit.	Sulfhydryl Compounds	0-5	thimet oligopeptidase 1	Rattus norvegicus	57-69
2185743-4	1990	Free thiol groups were also important for the catalytic activity of rat Pz-peptidase, as previously reported for the rabbit enzyme.	Sulfhydryl Compounds	5-10	thimet oligopeptidase 1	Rattus norvegicus	72-84
2185743-5	1990	We conclude that in both species Pz-peptidase has the characteristics of a thiol-dependent metallo-endopeptidase.	Sulfhydryl Compounds	75-80	thimet oligopeptidase 1	Rattus norvegicus	33-45
2371919-0	1990	Essential thiol and disulphide groups in the histamine H1-receptor signal transfer of guinea-pig parenchymal lung strips.	Sulfhydryl Compounds	10-15	histamine H1 receptor	Cavia porcellus	45-66
2350374-2	1990	We report here that the factor responsible is transforming growth factor beta (TGF-beta) as assessed by (1) protease and thiol sensitivity, (2) heat and acid enhancement of ECCM activity, and (3) neutralisation of ECCM activity by anti-TGF-beta-immunoglobulin.	Sulfhydryl Compounds	121-126	transforming growth factor beta 1	Homo sapiens	46-77
2383144-1	1990	The state of the thiol-dependent systems i.e. concentration of the SH-groups, activity of glutathione reductase and glutathione-S-transferase, carminomycin antitumor and toxic effects was studied under conditions of tumor growth and carminomycin therapy with the use of prophylactic rations (PR) aimed at stimulating the cell thiol-dependent and antioxidant systems for decreasing the drug toxic action.	Sulfhydryl Compounds	17-22	glutathione-disulfide reductase	Rattus norvegicus	90-111
2383144-1	1990	The state of the thiol-dependent systems i.e. concentration of the SH-groups, activity of glutathione reductase and glutathione-S-transferase, carminomycin antitumor and toxic effects was studied under conditions of tumor growth and carminomycin therapy with the use of prophylactic rations (PR) aimed at stimulating the cell thiol-dependent and antioxidant systems for decreasing the drug toxic action.	Sulfhydryl Compounds	17-22	hematopoietic prostaglandin D synthase	Rattus norvegicus	116-141
2350374-2	1990	We report here that the factor responsible is transforming growth factor beta (TGF-beta) as assessed by (1) protease and thiol sensitivity, (2) heat and acid enhancement of ECCM activity, and (3) neutralisation of ECCM activity by anti-TGF-beta-immunoglobulin.	Sulfhydryl Compounds	121-126	transforming growth factor beta 1	Homo sapiens	79-87
2109306-2	1990	The methyl group is transferred to an acceptor site cysteine thiol group in the enzyme, which causes the irreversible inactivation of O6-MT.	Sulfhydryl Compounds	61-66	O-6-methylguanine-DNA methyltransferase	Homo sapiens	134-139
2194812-4	1990	Special attention is paid to the presence of the sulphydryl moiety of certain ACE-inhibitors.	Sulfhydryl Compounds	49-59	angiotensin I converting enzyme	Homo sapiens	78-81
2310409-2	1990	Results from this study showed that incubation of Cd,Zn-MT with CCl4 in the presence of hepatic microsomes and NADPH resulted in a time-dependent depletion of MT thiols with a concurrent reduction in the metal-binding sites of the protein.	Sulfhydryl Compounds	162-168	C-C motif chemokine ligand 4	Homo sapiens	64-68
2189497-6	1990	The second intermediate is a flavin C(4a)-Cys140 thiol adduct, which is quantitatively accumulated by reaction of oxidized ACAA enzyme with NADP+.	Sulfhydryl Compounds	49-54	acetyl-CoA acyltransferase 1	Homo sapiens	123-127
2137820-8	1990	Inhibition of 125I-BOP binding after reduction with DTT could be made permanent by addition of the sulfhydryl alkylating agent N-ethylmaleimide (25 mM), but was completely reversed by reoxidation with dithionitrobenzoic acid (DTNB) (5 mM).	Sulfhydryl Compounds	99-109	BOP	Homo sapiens	19-22
2310409-6	1990	Measurement of the thiol content of CCl4-treated MT after treatment with 1,4-dithiothreitol revealed that all the thiol groups that were lost subsequent to CCl4 treatment could be regenerated.	Sulfhydryl Compounds	114-119	C-C motif chemokine ligand 4	Homo sapiens	36-40
2310409-6	1990	Measurement of the thiol content of CCl4-treated MT after treatment with 1,4-dithiothreitol revealed that all the thiol groups that were lost subsequent to CCl4 treatment could be regenerated.	Sulfhydryl Compounds	114-119	C-C motif chemokine ligand 4	Homo sapiens	156-160
2310409-4	1990	Results from experiments conducted to determine whether or not the CCl4-induced decrease in MT-thiol content was due to the scavenging of CCl4 metabolite(s) showed that the trichloromethyl radical, chloroform and phosgene as well as the products of CCl4-induced microsomal lipid peroxidation were not directly involved.	Sulfhydryl Compounds	95-100	C-C motif chemokine ligand 4	Homo sapiens	67-71
2310409-6	1990	Measurement of the thiol content of CCl4-treated MT after treatment with 1,4-dithiothreitol revealed that all the thiol groups that were lost subsequent to CCl4 treatment could be regenerated.	Sulfhydryl Compounds	19-24	C-C motif chemokine ligand 4	Homo sapiens	36-40
2310409-6	1990	Measurement of the thiol content of CCl4-treated MT after treatment with 1,4-dithiothreitol revealed that all the thiol groups that were lost subsequent to CCl4 treatment could be regenerated.	Sulfhydryl Compounds	19-24	C-C motif chemokine ligand 4	Homo sapiens	156-160
2303061-2	1990	L-FABP-SSG, which was prepared in vitro through thiol-disulfide exchange reaction, showed more acidic pI (approximately 5.0) than the pI (approximately 7.0) of reduced L-FABP.	Sulfhydryl Compounds	48-53	fatty acid binding protein 1	Rattus norvegicus	0-6
1972536-4	1990	Among GroEL homologues, the chlamydial protein (chl-GroEL) uniquely displays affinity towards immobilized thiol groups.	Sulfhydryl Compounds	106-111	GroEL	Escherichia coli	6-11
1972536-4	1990	Among GroEL homologues, the chlamydial protein (chl-GroEL) uniquely displays affinity towards immobilized thiol groups.	Sulfhydryl Compounds	106-111	GroEL	Escherichia coli	52-57
1692242-0	1990	Inhibition and partial reversal of the methylamine-induced conversion of "slow" to "fast" electrophoretic forms of human alpha 2-macroglobulin by modification of the thiols.	Sulfhydryl Compounds	166-172	alpha-2-macroglobulin	Homo sapiens	121-142
1692242-6	1990	One mole of DNPS is liberated per mole of free thiol in alpha 2M, consistent with cyanylation of the thiol liberated upon scission of the internal thiol esters by methylamine.	Sulfhydryl Compounds	47-52	alpha-2-macroglobulin	Homo sapiens	56-64
1692242-6	1990	One mole of DNPS is liberated per mole of free thiol in alpha 2M, consistent with cyanylation of the thiol liberated upon scission of the internal thiol esters by methylamine.	Sulfhydryl Compounds	101-106	alpha-2-macroglobulin	Homo sapiens	56-64
1692242-7	1990	I3(-) can also react with the methylamine-generated thiol groups of alpha 2M with a stoichiometry consistent with conversion of the thiol to a sulfenyl iodide.	Sulfhydryl Compounds	52-57	alpha-2-macroglobulin	Homo sapiens	68-76
1692242-7	1990	I3(-) can also react with the methylamine-generated thiol groups of alpha 2M with a stoichiometry consistent with conversion of the thiol to a sulfenyl iodide.	Sulfhydryl Compounds	132-137	alpha-2-macroglobulin	Homo sapiens	68-76
1692242-8	1990	Reaction of the thiol groups with either DNPSCN or I3(-) inhibits the conversion of alpha 2M from the "slow" to the "fast" electrophoretic form.	Sulfhydryl Compounds	16-21	alpha-2-macroglobulin	Homo sapiens	84-92
2342485-10	1990	Interestingly, Zn,Cd-MT and apothionein had an equivalent number of accessible thiols.	Sulfhydryl Compounds	79-85	CYLD lysine 63 deubiquitinase	Homo sapiens	18-23
2324766-0	1990	Giant axonal neuropathy: studies with sulfhydryl donor compounds.	Sulfhydryl Compounds	38-48	gigaxonin	Homo sapiens	0-23
1692242-10	1990	A similar reversal can be effected by cyanylation, with NaCN, of methylamine-treated alpha 2M in which the liberated thiols have first been converted to mixed disulfides by reaction with dithiobis(nitrobenzoic acid).	Sulfhydryl Compounds	117-123	alpha-2-macroglobulin	Homo sapiens	85-93
2313588-1	1990	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds including thiopurine drugs such as 6-mercaptopurine.	Sulfhydryl Compounds	93-103	thiopurine methyltransferase	Mus musculus	0-28
2313588-1	1990	Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of aromatic and heterocyclic sulfhydryl compounds including thiopurine drugs such as 6-mercaptopurine.	Sulfhydryl Compounds	93-103	thiopurine methyltransferase	Mus musculus	30-34
2324766-3	1990	We report, in GAN fibroblasts, inhibition of vimentin filament aggregation by dithiothreitol and penicillamine, sulfhydryl donor compounds which stabilize thiols.	Sulfhydryl Compounds	112-122	gigaxonin	Homo sapiens	14-17
2324766-3	1990	We report, in GAN fibroblasts, inhibition of vimentin filament aggregation by dithiothreitol and penicillamine, sulfhydryl donor compounds which stabilize thiols.	Sulfhydryl Compounds	112-122	vimentin	Homo sapiens	45-53
2324766-3	1990	We report, in GAN fibroblasts, inhibition of vimentin filament aggregation by dithiothreitol and penicillamine, sulfhydryl donor compounds which stabilize thiols.	Sulfhydryl Compounds	155-161	gigaxonin	Homo sapiens	14-17
2324766-3	1990	We report, in GAN fibroblasts, inhibition of vimentin filament aggregation by dithiothreitol and penicillamine, sulfhydryl donor compounds which stabilize thiols.	Sulfhydryl Compounds	155-161	vimentin	Homo sapiens	45-53
2324766-5	1990	These findings support the hypothesis of disordered thiol metabolism in GAN, and open up avenues for further research.	Sulfhydryl Compounds	52-57	gigaxonin	Homo sapiens	72-75
2168295-6	1990	Superoxide dismutase (SOD) inhibits both thiol oxidation and oxygen consumption as well as oxidation of NAD(P)H if present in the mixture.	Sulfhydryl Compounds	41-46	superoxide dismutase 1	Homo sapiens	0-20
2294968-1	1990	Using the fluorescent sulfhydryl probe, 5-iodoacetamidofluoresceine, to label the free sulfhydryl of low-density lipoprotein, the positions of two cysteine residues in apolipoprotein B were located.	Sulfhydryl Compounds	22-32	apolipoprotein B	Homo sapiens	168-184
2404442-7	1990	L-cysteine ethyl ester hydrochloride, a sulfhydryl type of agent, reduced both G" and eta".	Sulfhydryl Compounds	40-50	endothelin receptor type A	Homo sapiens	86-89
2297224-1	1990	The activity of the thiol-dependent enzyme glyceraldehyde-3-phosphate dehydrogenase (GPD), in vertebrate cells, was modulated by a change in the intracellular thiol:disulfide redox status.	Sulfhydryl Compounds	20-25	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	43-83
2297224-1	1990	The activity of the thiol-dependent enzyme glyceraldehyde-3-phosphate dehydrogenase (GPD), in vertebrate cells, was modulated by a change in the intracellular thiol:disulfide redox status.	Sulfhydryl Compounds	20-25	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	85-88
2297224-1	1990	The activity of the thiol-dependent enzyme glyceraldehyde-3-phosphate dehydrogenase (GPD), in vertebrate cells, was modulated by a change in the intracellular thiol:disulfide redox status.	Sulfhydryl Compounds	159-164	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	43-83
2297224-1	1990	The activity of the thiol-dependent enzyme glyceraldehyde-3-phosphate dehydrogenase (GPD), in vertebrate cells, was modulated by a change in the intracellular thiol:disulfide redox status.	Sulfhydryl Compounds	159-164	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	85-88
2297224-3	1990	Loss of reduced protein thiols, as measured by binding of the thiol reagent iodoacetic acid to GPD, and loss of GPD enzymatic activity occurred in a dose-dependent manner.	Sulfhydryl Compounds	24-30	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	95-98
2297224-3	1990	Loss of reduced protein thiols, as measured by binding of the thiol reagent iodoacetic acid to GPD, and loss of GPD enzymatic activity occurred in a dose-dependent manner.	Sulfhydryl Compounds	24-29	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	95-98
2297224-5	1990	The enzymatic recovery of GPD activity was observed either without addition of thiols to the medium or by incubation of a sonicated cell mixture with 2 mM cysteine, cystine, cysteamine, or glutathione (GSH); GSSG had no effect.	Sulfhydryl Compounds	79-85	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	26-29
2297224-8	1990	These findings indicate that the cellular thiol redox status can be important in determining GPD enzymatic activity.	Sulfhydryl Compounds	42-47	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	93-96
2403372-0	1990	Inhibitory effect of thiols on the degradation of albumin by human spleen cathepsin D.	Sulfhydryl Compounds	21-27	cathepsin D	Homo sapiens	74-85
2403372-4	1990	These effects of thiols which have not been observed in other animal cathepsin D, suggest an essential function for cathepsin D in the human spleen.	Sulfhydryl Compounds	17-23	cathepsin D	Homo sapiens	69-80
2403372-4	1990	These effects of thiols which have not been observed in other animal cathepsin D, suggest an essential function for cathepsin D in the human spleen.	Sulfhydryl Compounds	17-23	cathepsin D	Homo sapiens	116-127
2168295-6	1990	Superoxide dismutase (SOD) inhibits both thiol oxidation and oxygen consumption as well as oxidation of NAD(P)H if present in the mixture.	Sulfhydryl Compounds	41-46	superoxide dismutase 1	Homo sapiens	22-25
1366419-1	1990	Intramolecular thiolester bonds in apolipoprotein B (ApoB) were studied using [14C]methylamine (MA) to cleave the thiolester and [3H]- or [14C]iodoacetate (IA) to titrate the newly generated sulfhydryls.	Sulfhydryl Compounds	191-202	apolipoprotein B	Homo sapiens	35-51
1978256-8	1990	The enzyme is a metallo- and thiol-dependent and chloride-activated, low-molecular weight aminopeptidase.	Sulfhydryl Compounds	29-34	carboxypeptidase Q	Homo sapiens	90-104
2136727-8	1990	Moreover, T4-induced rANP mRNA accumulation in atrial myocytes was further stimulated by the addition of dithiothreitol, suggesting that the deiodinating activity was thiol sensitive.	Sulfhydryl Compounds	167-172	natriuretic peptide A	Rattus norvegicus	21-25
2228734-2	1990	Sulfhydryl oxidase (SOx), an enzyme that catalyzes the oxidation of sulfhydryl compounds, appears in the spermatogenic cells of rat and hamster testes in a stage-dependent manner.	Sulfhydryl Compounds	68-88	quiescin sulfhydryl oxidase 1	Rattus norvegicus	0-18
2228734-2	1990	Sulfhydryl oxidase (SOx), an enzyme that catalyzes the oxidation of sulfhydryl compounds, appears in the spermatogenic cells of rat and hamster testes in a stage-dependent manner.	Sulfhydryl Compounds	68-88	quiescin sulfhydryl oxidase 1	Rattus norvegicus	20-23
1366419-1	1990	Intramolecular thiolester bonds in apolipoprotein B (ApoB) were studied using [14C]methylamine (MA) to cleave the thiolester and [3H]- or [14C]iodoacetate (IA) to titrate the newly generated sulfhydryls.	Sulfhydryl Compounds	191-202	apolipoprotein B	Homo sapiens	53-57
33765599-4	2021	Under varying degrees of MDA oxidation, the addition of TGase always led to changes in the tertiary structure, loss of free amine and thiol groups, crosslinking of the myosin heavy chain, and decreasing solubility.	Sulfhydryl Compounds	134-139	transglutaminase 1	Homo sapiens	56-61
2218732-7	1990	Therefore, increased concentrations of sulfhydryl compounds, mostly of reduced glutathione are necessary for an optimal ALA-D activity.	Sulfhydryl Compounds	39-59	aminolevulinate dehydratase	Homo sapiens	120-125
33793228-3	2021	Nucleophilic sites in serum albumin-particularly the free thiol at Cys34-form adducts with electrophiles.	Sulfhydryl Compounds	58-63	albumin	Homo sapiens	28-35
33813822-4	2021	Novel Pluronic-based micelles are designed with the pendant pyridyl disulfide group, which are used to conjugate TF-targeting siRNA by the thiol-exchange reaction.	Sulfhydryl Compounds	139-144	coagulation factor III, tissue factor	Homo sapiens	113-115
33973343-2	2021	IRC7, a gene encoding a cysteine-S-beta-lyase enzyme related volatile thiols production in wines, has two alleles: a full-length allele (IRC7F ) and a mutated one (IRC7S ), harbouring a 38bp-deletion.	Sulfhydryl Compounds	70-76	cysteine-S-conjugate beta-lyase IRC7	Saccharomyces cerevisiae S288C	0-4
33761747-5	2021	Their reactivity toward thiols is tunable and correlates with the pKa/pKb of the leaving group.	Sulfhydryl Compounds	24-30	AKT serine/threonine kinase 1	Homo sapiens	70-73
33761747-6	2021	In the context of the BTK inhibitor ibrutinib, these electrophiles showed lower intrinsic thiol reactivity than the unsubstituted ibrutinib acrylamide.	Sulfhydryl Compounds	90-95	Bruton tyrosine kinase	Homo sapiens	22-25
19161347-2	2009	The electrophilic cyclopentenone 15d-PGJ2 (15-deoxy-Delta(12,14)-prostaglandin J2) induces the expression of HO-1 protein through the covalent modification of protein thiols.	Sulfhydryl Compounds	167-173	heme oxygenase 1	Homo sapiens	109-113
26122708-6	2015	Its ability to orchestrate adaptation to oxidants and electrophiles is due principally to stress-stimulated modification of thiols within one of its repressors, the Kelch-like ECH-associated protein 1 (Keap1), which is present in the cullin-3 RING ubiquitin ligase (CRL) complex CRLKeap1.	Sulfhydryl Compounds	124-130	kelch like ECH associated protein 1	Homo sapiens	165-200
26122708-6	2015	Its ability to orchestrate adaptation to oxidants and electrophiles is due principally to stress-stimulated modification of thiols within one of its repressors, the Kelch-like ECH-associated protein 1 (Keap1), which is present in the cullin-3 RING ubiquitin ligase (CRL) complex CRLKeap1.	Sulfhydryl Compounds	124-130	kelch like ECH associated protein 1	Homo sapiens	202-207
23696645-4	2013	We used a quantitative redox proteomic method based on isotope-coded affinity tag chemistry and identified four proteins consistently thiol-modified in cells treated with peroxynitrite as follows: AsnB, FrmA, MaeB, and RidA.	Sulfhydryl Compounds	134-139	alcohol dehydrogenase class-III	Escherichia coli	203-207
19135121-3	2009	The thioredoxin (Trx) system is essential for the maintenance of cellular thiol redox balance, and is critical for cell survival.	Sulfhydryl Compounds	74-79	thioredoxin	Homo sapiens	4-15
19135121-3	2009	The thioredoxin (Trx) system is essential for the maintenance of cellular thiol redox balance, and is critical for cell survival.	Sulfhydryl Compounds	74-79	thioredoxin	Homo sapiens	17-20
33814511-1	2021	Chemical modification of the thiol group on protein tyrosine phosphatase (PTP) 1B triggers an activation of epidermal growth factor receptor (EGFR) signaling that is mimicked by environmental electrophiles through S-modification of PTP1B.	Sulfhydryl Compounds	29-34	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	44-81
33814511-1	2021	Chemical modification of the thiol group on protein tyrosine phosphatase (PTP) 1B triggers an activation of epidermal growth factor receptor (EGFR) signaling that is mimicked by environmental electrophiles through S-modification of PTP1B.	Sulfhydryl Compounds	29-34	epidermal growth factor receptor	Homo sapiens	108-140
33814511-1	2021	Chemical modification of the thiol group on protein tyrosine phosphatase (PTP) 1B triggers an activation of epidermal growth factor receptor (EGFR) signaling that is mimicked by environmental electrophiles through S-modification of PTP1B.	Sulfhydryl Compounds	29-34	epidermal growth factor receptor	Homo sapiens	142-146
33814511-1	2021	Chemical modification of the thiol group on protein tyrosine phosphatase (PTP) 1B triggers an activation of epidermal growth factor receptor (EGFR) signaling that is mimicked by environmental electrophiles through S-modification of PTP1B.	Sulfhydryl Compounds	29-34	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	232-237
19161347-3	2009	It has been shown that specific thiol residues of the redox-sensor Keap1 (Kelch-like ECH-associated protein 1) are modified by 15d-PGJ2, leading to activation of the transcription factor Nrf-2 (nuclear factor-erythroid 2 p45 subunit-related factor 2) and up-regulation of genes under control of the electrophile-response element, including HO-1.	Sulfhydryl Compounds	32-37	kelch like ECH associated protein 1	Homo sapiens	67-72
19161347-3	2009	It has been shown that specific thiol residues of the redox-sensor Keap1 (Kelch-like ECH-associated protein 1) are modified by 15d-PGJ2, leading to activation of the transcription factor Nrf-2 (nuclear factor-erythroid 2 p45 subunit-related factor 2) and up-regulation of genes under control of the electrophile-response element, including HO-1.	Sulfhydryl Compounds	32-37	kelch like ECH associated protein 1	Homo sapiens	74-109
16778134-8	2006	OxLDL or exogenous H2O2 oxidized GAPDH thiols, decreasing GAPDH protein half-life and increasing GAPDH sensitivity to proteasome-mediated protein degradation in vitro.	Sulfhydryl Compounds	39-45	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	33-38
19161347-3	2009	It has been shown that specific thiol residues of the redox-sensor Keap1 (Kelch-like ECH-associated protein 1) are modified by 15d-PGJ2, leading to activation of the transcription factor Nrf-2 (nuclear factor-erythroid 2 p45 subunit-related factor 2) and up-regulation of genes under control of the electrophile-response element, including HO-1.	Sulfhydryl Compounds	32-37	NFE2 like bZIP transcription factor 2	Homo sapiens	187-249
19161347-3	2009	It has been shown that specific thiol residues of the redox-sensor Keap1 (Kelch-like ECH-associated protein 1) are modified by 15d-PGJ2, leading to activation of the transcription factor Nrf-2 (nuclear factor-erythroid 2 p45 subunit-related factor 2) and up-regulation of genes under control of the electrophile-response element, including HO-1.	Sulfhydryl Compounds	32-37	heme oxygenase 1	Homo sapiens	340-344
8530919-10	1995	The conjugation of maleimide with thiol group results in the decrease of Cd2+ high-affinitive binding sites from 6 to 1.	Sulfhydryl Compounds	34-39	CD2 molecule	Homo sapiens	73-76
34894545-2	2022	In this study, bovine serum albumin-MIPs (BSA-MIPs) were successfully prepared by orchestrating the involvement of orientation-controllable binding ligands via sequential thiol-ene click and thiol-ene-amine conjugation.	Sulfhydryl Compounds	171-176	albumin	Homo sapiens	22-35
34902643-8	2022	The thiol-modified (SH-) CD63 DNA aptamer was introduced as the bio-probe that selectively binds to the CD63 protein on the exosome surface.	Sulfhydryl Compounds	4-9	CD63 molecule	Homo sapiens	25-29
34902643-8	2022	The thiol-modified (SH-) CD63 DNA aptamer was introduced as the bio-probe that selectively binds to the CD63 protein on the exosome surface.	Sulfhydryl Compounds	4-9	CD63 molecule	Homo sapiens	104-108
34973770-1	2022	To achieve synergistic reinforcing and cross-linking effect across interface between hydrophilic nanocellulose and hydrophobic rubber, active thiol groups were introduced at reducing end of CNF while retaining hydroxyl groups on the surface, thus forming a percolation network in nanocomposites.	Sulfhydryl Compounds	142-147	NPHS1 adhesion molecule, nephrin	Homo sapiens	190-193
34973770-2	2022	The nanocomposites were obtained by casting/evaporating a mixture of dispersed modified CNF and NR in latex form, in which covalent cross-links were formed between thiol groups and double bonds of NR via photochemically initiated thiol-ene reaction.	Sulfhydryl Compounds	164-169	NPHS1 adhesion molecule, nephrin	Homo sapiens	88-91
34973770-2	2022	The nanocomposites were obtained by casting/evaporating a mixture of dispersed modified CNF and NR in latex form, in which covalent cross-links were formed between thiol groups and double bonds of NR via photochemically initiated thiol-ene reaction.	Sulfhydryl Compounds	230-235	NPHS1 adhesion molecule, nephrin	Homo sapiens	88-91
34954641-4	2022	Herein, we demonstrated that TrxR1 catalyzed plumbagin reduction in both selenocysteine (Sec)-dependent and independent manners, and its activity relied on the intact N-terminal motif of TrxR1, but a high-efficiency reduction was supported by the C-terminal thiols.	Sulfhydryl Compounds	258-264	thioredoxin reductase 1	Homo sapiens	29-34
34879578-0	2022	Competitive exchange between divalent metal ions (Cu(II), Zn(II), Ca(II)) and Hg(II) bound to thiols and natural organic matter.	Sulfhydryl Compounds	94-100	carbonic anhydrase 2	Homo sapiens	66-72
34968849-3	2022	In this research, a novel fluorescent probe named "probe for acrolein detection" (Pr-ACR) was designed and synthesized based on a naphthalimide fluorophore skeleton, and a thiol group (-SH) was introduced into its structure for acrolein recognition.	Sulfhydryl Compounds	172-177	acrosin	Homo sapiens	85-88
34894577-0	2022	Identification of NLRP3 as a covalent target of 1,6-O,O-diacetylbritannilactone against neuroinflammation by quantitative thiol reactivity profiling (QTRP).	Sulfhydryl Compounds	122-127	NLR family, pyrin domain containing 3	Mus musculus	18-23
34894577-5	2022	Here, we employed an adapted isoTOP-ABPP, quantitative thiol reactivity profiling (QTRP) approach, to identify and quantify thiol reactivity binding proteins in murine microglia BV-2 cells.	Sulfhydryl Compounds	124-129	amyloid beta (A4) precursor protein	Mus musculus	36-40
34896750-1	2022	Irreversible Bruton"s tyrosine kinase (BTK) inhibitor drugs are designed to bind covalently to a free-thiol cysteine in the BTK protein active site.	Sulfhydryl Compounds	102-107	Bruton tyrosine kinase	Homo sapiens	13-37
34896750-1	2022	Irreversible Bruton"s tyrosine kinase (BTK) inhibitor drugs are designed to bind covalently to a free-thiol cysteine in the BTK protein active site.	Sulfhydryl Compounds	102-107	Bruton tyrosine kinase	Homo sapiens	39-42
34896750-1	2022	Irreversible Bruton"s tyrosine kinase (BTK) inhibitor drugs are designed to bind covalently to a free-thiol cysteine in the BTK protein active site.	Sulfhydryl Compounds	102-107	Bruton tyrosine kinase	Homo sapiens	124-127
34893948-3	2022	We investigated the effect of pH, Ca2+, Mg2+ and anionic phospholipids on the reduction of cytochrome c by glutathione.The reduction of cytochrome c by thiols was measured using photometry.	Sulfhydryl Compounds	152-158	cytochrome c, somatic	Homo sapiens	136-148
34517051-0	2022	Decreased cortical Nrf2 gene expression in autism and its relationship to thiol and cobalamin status.	Sulfhydryl Compounds	74-79	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
34455628-5	2022	Here we present a multiscale approach to model thiol inhibitor binding to IMP-1, a clinically important MBL containing two catalytic zinc ions, and predict the binding mode of a 2-mercaptomethyl thiazolidine (MMTZ) inhibitor.	Sulfhydryl Compounds	47-52	insulin like growth factor 2 mRNA binding protein 1	Homo sapiens	74-79
34455628-5	2022	Here we present a multiscale approach to model thiol inhibitor binding to IMP-1, a clinically important MBL containing two catalytic zinc ions, and predict the binding mode of a 2-mercaptomethyl thiazolidine (MMTZ) inhibitor.	Sulfhydryl Compounds	47-52	mannose-binding lectin family member 3, pseudogene	Homo sapiens	104-107
34883205-8	2022	The yields of mono-PEGylated AAT following purification by anion exchange chromatography were 40 - 50 % for N-terminal PEGylation and 60 - 70 % for thiol PEGylation.	Sulfhydryl Compounds	148-153	serpin family A member 1	Homo sapiens	29-32
34837848-2	2022	We used tri-isopropylsilyl thioglycosides as masked glycosyl thiol nucleophiles for the elaboration of two monofluorinated heterodimers, one difluorinated homodimer, and one difluorinated heterodimer.	Sulfhydryl Compounds	61-66	superoxide dismutase 1	Homo sapiens	155-164
34850059-5	2021	The binding assay using PC2 or PC3-attached beads suggested positive binding between PCs and Ni(II), Cu(II), Zn(II), Cd(II), and As(III) in accordance with the number of thiols in PC2 and PC3.	Sulfhydryl Compounds	170-176	polycystin 2, transient receptor potential cation channel	Homo sapiens	24-27
34951511-0	2022	Covalently Crosslinked Pig Gastric Mucin Hydrogels Prepared by Radical-based Chain-Growth and Thiol-ene Mechanisms.	Sulfhydryl Compounds	94-99	LOC100188911	Sus scrofa	27-40
34936227-4	2022	Hydrogels are formed by a photo-initiated thiol-ene reaction between multi-arm polyethylene glycol (PEG) and a dually enzymatically degradable peptide linker, which incorporates a thrombin-degradable sequence for triggered softening and a matrix metalloproteinase (MMP)-degradable sequence for cell-driven remodeling.	Sulfhydryl Compounds	42-47	coagulation factor II, thrombin	Homo sapiens	180-188
34850059-5	2021	The binding assay using PC2 or PC3-attached beads suggested positive binding between PCs and Ni(II), Cu(II), Zn(II), Cd(II), and As(III) in accordance with the number of thiols in PC2 and PC3.	Sulfhydryl Compounds	170-176	chromobox 8	Homo sapiens	31-34
34850059-5	2021	The binding assay using PC2 or PC3-attached beads suggested positive binding between PCs and Ni(II), Cu(II), Zn(II), Cd(II), and As(III) in accordance with the number of thiols in PC2 and PC3.	Sulfhydryl Compounds	170-176	polycystin 2, transient receptor potential cation channel	Homo sapiens	180-183
34923938-12	2021	Inhibition of TrxR results in a decrease of thiols content and total glutathione elevates reactive oxygen species levels, and finally promotes oxidative stress-mediated apoptosis of cancer cells.	Sulfhydryl Compounds	44-50	peroxiredoxin 5	Homo sapiens	14-18
34740294-7	2021	Sulfur deficiency mainly reduced the abundance of thiol groups, which are essential redox modulators as well as xenobiotic conjugators, and significantly inhibited GSTs expression.	Sulfhydryl Compounds	50-55	glutathione S-transferase kappa 1	Homo sapiens	164-168
34851151-4	2021	We found that loss of ClpE leads to increased susceptibility against thiol stress but not to oxidative and thermal stress.	Sulfhydryl Compounds	69-74	ATP-dependent Clp protease ATP-binding subunit	Streptococcus mutans UA159	22-26
34595834-1	2021	An albumin-binding CsA analogue 4MCsA was achieved by attachment of a thiol-reactive maleimide group at the side-chain of P4 position of CsA derivative.	Sulfhydryl Compounds	70-75	albumin	Homo sapiens	3-10
34911160-6	2022	An appropriate choice of protecting groups for the thiol in the glycosyl donor is necessary for the development of iterative synthesis of thio-oligosaccharides.	Sulfhydryl Compounds	51-56	acetyl-CoA acyltransferase 1	Homo sapiens	138-142
34813297-0	2021	Improved Thermal Stability and Homogeneity of Low Probe Density DNA SAMs Using Potential-Assisted Thiol-Exchange Assembly Methods.	Sulfhydryl Compounds	98-103	methionine adenosyltransferase 1A	Homo sapiens	68-72
34797669-6	2021	More importantly, our analogue was produced in quantitative yield from a monomeric thiol insulin scaffold.	Sulfhydryl Compounds	83-88	insulin	Homo sapiens	89-96
34910435-11	2021	Higher IMA levels and lower native thiol levels were found in patients with the ASXL1 mutation (p < 0.001).	Sulfhydryl Compounds	35-40	ASXL transcriptional regulator 1	Homo sapiens	80-85
34857874-4	2021	Thiol(SH)-linked alkylation for the metabolic sequencing of RNA (SLAM seq) with target-transcriptional analyses further confirm that the viral peptide directly attenuates MYC and MYC-target gene expression.	Sulfhydryl Compounds	0-5	signaling lymphocytic activation molecule family member 1	Mus musculus	65-69
34813297-10	2021	The potential-assisted thiol-exchange approach to preparing low-coverage DNA SAMs was shown to quickly create modified surfaces that were consistent, had mobility characteristics which should yield superior DNA hybridization efficiencies, and having greater thermal stability which will translate into a longer shelf-life.	Sulfhydryl Compounds	23-28	methionine adenosyltransferase 1A	Homo sapiens	77-81
34910441-0	2021	Investigation of the Correlation between Meteorin-Like Protein (Metrnl) and Thiol Balance in COVID-19 Patients.	Sulfhydryl Compounds	76-81	meteorin like, glial cell differentiation regulator	Homo sapiens	41-62
34910441-0	2021	Investigation of the Correlation between Meteorin-Like Protein (Metrnl) and Thiol Balance in COVID-19 Patients.	Sulfhydryl Compounds	76-81	meteorin like, glial cell differentiation regulator	Homo sapiens	64-70
34910441-1	2021	BACKGROUND: The aim of this study is to investigate the correlation between serum meteorin-like protein levels and thiol/disulfide balance in patients with COVID-19.	Sulfhydryl Compounds	115-120	meteorin like, glial cell differentiation regulator	Homo sapiens	82-103
34850511-2	2022	Herein, by using the sensor of quartz crystal microbalance (QCM) as the sacrificial probe, the etching reaction of gold has been studied in employing cysteamine (CS) as a typical thiol etchant.	Sulfhydryl Compounds	179-184	citrate synthase	Homo sapiens	162-164
34678616-6	2021	Here we show that this antagonistic effect can be attributed to human serum albumin, which represents the largest pool of free thiols in plasma for trapping reactive oxygen species.	Sulfhydryl Compounds	127-133	albumin	Homo sapiens	70-83
34656698-5	2021	Pharmacological inhibition of TrxR by EriB results in elevated ROS levels, reduced total GSH and thiols content, which ultimately induced potent RKO cell apoptosis mediated by oxidative stress.	Sulfhydryl Compounds	97-103	peroxiredoxin 5	Homo sapiens	30-34
34974861-3	2021	Transmission electron microscopy and gel electrophoresis studies showed that albumin can bind to Mal-Lip due to the chemical coupling of the albumin thiol groups with the maleimide group.	Sulfhydryl Compounds	149-154	albumin	Mus musculus	77-84
34974861-3	2021	Transmission electron microscopy and gel electrophoresis studies showed that albumin can bind to Mal-Lip due to the chemical coupling of the albumin thiol groups with the maleimide group.	Sulfhydryl Compounds	149-154	albumin	Mus musculus	141-148
34310500-2	2021	METHODS: The total thiol groups of serum proteins (TTP), which can be considered as a proxy biomarker for the antioxidant defense capacity of cells and the derivatives of reactive oxygen metabolites (D-ROM) serum concentration, which is mainly a biomarker of lipid peroxidation, were measured in 2,572 participants of a population-based cohort study of older adults (age range: 57-83 years) of whom 2,068 had repeated measurements 3 years later.	Sulfhydryl Compounds	19-24	ZFP36 ring finger protein	Homo sapiens	51-54
34850511-4	2022	It is demonstrated that intact thiol and amino on CS are both crucial for its etching ability to gold.	Sulfhydryl Compounds	31-36	citrate synthase	Homo sapiens	50-52
34943032-5	2021	In the presence of oxidative and electrophilic insults, the thiol moieties of cysteine in KEAP1 are modified, and consequently NRF2 activates its target genes for detoxification and cytoprotection.	Sulfhydryl Compounds	60-65	kelch like ECH associated protein 1	Homo sapiens	90-95
34850511-6	2022	Our results also reveal that only two carbon atoms of the spacer between thiol and amino on CS are very critical to the excellent etching ability.	Sulfhydryl Compounds	73-78	citrate synthase	Homo sapiens	92-94
34943032-5	2021	In the presence of oxidative and electrophilic insults, the thiol moieties of cysteine in KEAP1 are modified, and consequently NRF2 activates its target genes for detoxification and cytoprotection.	Sulfhydryl Compounds	60-65	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
34752599-14	2022	Finally, ERp46-deficient platelets have decreased thiols in beta3 implying that ERp46 cleaves disulfide bonds in platelets.	Sulfhydryl Compounds	50-56	thioredoxin domain containing 5	Mus musculus	9-14
34814838-0	2021	The thiol-disulfide exchange activity of AtPDI1 is involved in the response to abiotic stresses.	Sulfhydryl Compounds	4-9	PDI-like 1-3	Arabidopsis thaliana	41-47
34726214-1	2021	Thiol-functionalized UiO-66-anchored atomically dispersed metal ions, denoted as UiO-66(SM)2 (M = Pd, Pt, or Au), were prepared as photocatalysts for the selective oxidation of benzyl alcohol (BA) to benzaldehyde (BAD) under visible light irradiation.	Sulfhydryl Compounds	0-5	SM2	Homo sapiens	81-92
34847145-0	2021	Trichinella spiralis: Knockdown of gamma interferon inducible lysosomal thiol reductase (GILT) results in the reduction of worm burden.	Sulfhydryl Compounds	72-77	interferon gamma inducible protein 30	Mus musculus	89-93
34847145-2	2021	Gamma interferon inducible lysosomal thiol reductase (GILT) is a widespread superfamily which plays key role in processing and presentation of MHC class II restricted antigen by catalyzing disulfide bond reduction.	Sulfhydryl Compounds	37-42	IFI30 lysosomal thiol reductase	Homo sapiens	54-58
34738793-5	2021	We achieved the well-controlled step-growth hydrosilylation polymerizations of the electron-rich diene and bis(silane) monomer due to the selective activation of Si-H bonds by the organic photocatalyst (4CzIPN) and the thiol polarity reversal reagent (HAT 1).	Sulfhydryl Compounds	219-224	histone acetyltransferase 1	Homo sapiens	252-257
34473153-2	2021	Many of these complexes perform catalase reactions via high-valent Mn-oxo or -hydroxo intermediates that oxidize H2O2 to O2, but these intermediates can also oxidize other molecules (e.g., thiols), which is peroxidase reactivity.	Sulfhydryl Compounds	189-195	catalase	Homo sapiens	32-40
34752599-14	2022	Finally, ERp46-deficient platelets have decreased thiols in beta3 implying that ERp46 cleaves disulfide bonds in platelets.	Sulfhydryl Compounds	50-56	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	60-65
34752599-14	2022	Finally, ERp46-deficient platelets have decreased thiols in beta3 implying that ERp46 cleaves disulfide bonds in platelets.	Sulfhydryl Compounds	50-56	thioredoxin domain containing 5	Mus musculus	80-85
34364452-1	2021	Herein, an amplified and renewable electrochemical biosensor was developed via bienzymatic cascade catalysis of glucose oxidase (GOx) and horseradish peroxidase (HRP), which were confined in a functional Y-shaped DNA nanostructure oriented by a dual-thiol-ended hairpin probe (dSH-HP) with a paired stem as a rigid scaffold and unpaired loop as enclosed binding platform.	Sulfhydryl Compounds	250-255	dishevelled	Drosophila melanogaster	277-280
34558135-2	2021	The interaction between the SARS-CoV-2 spike protein and the human receptor angiotensin-converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide-thiol balance in the host cell.	Sulfhydryl Compounds	187-192	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	39-44
34558135-2	2021	The interaction between the SARS-CoV-2 spike protein and the human receptor angiotensin-converting enzyme 2, both of which contain several cysteine residues, is impacted by the disulfide-thiol balance in the host cell.	Sulfhydryl Compounds	187-192	angiotensin converting enzyme 2	Homo sapiens	76-107
34089843-7	2021	We also speculate on the possibility that the ER stress response might regulate the above effects on the intraluminal crosstalk between the IP3R and the RyR via oxidation of critical thiols mediated by the H2O2 locally released by oxidoreductin 1alpha.	Sulfhydryl Compounds	183-189	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	140-144
34089843-7	2021	We also speculate on the possibility that the ER stress response might regulate the above effects on the intraluminal crosstalk between the IP3R and the RyR via oxidation of critical thiols mediated by the H2O2 locally released by oxidoreductin 1alpha.	Sulfhydryl Compounds	183-189	ryanodine receptor 2	Homo sapiens	153-156
34668910-1	2021	We have proven that pyridine-boryl complexes can be used as superelectron donors to promote the coupling of thiols and aromatic halides through a SRN1 mechanism.	Sulfhydryl Compounds	108-114	NPHS2 stomatin family member, podocin	Homo sapiens	146-150
34827248-8	2021	This report presents a broad evaluation of the antibacterial effect of PTP inhibition and redox thiol oxidation, illustrates the functional diversity of bacterial PTPs and redox thiols, and supports their consideration as novel targets for antimicrobial drug development.	Sulfhydryl Compounds	178-184	protein tyrosine phosphatase receptor type U	Homo sapiens	71-74
34647549-0	2021	Turn on chemiluminescence-based probes for monitoring tyrosinase activity in conjunction with biological thiols.	Sulfhydryl Compounds	105-111	tyrosinase	Homo sapiens	54-64
34778376-7	2021	Human IL-15 with its polypeptide sequence modified at the C-terminus to enable thiol conjugation with membrane localizing peptides, was produced in E. coli and purified using mild denaturing conditions (2M urea) from a washing step or from solubilization of inclusion bodies.	Sulfhydryl Compounds	79-84	interleukin 15	Homo sapiens	6-11
34771233-10	2021	Moreover, the terminal thiol end-functionality in the (PNVCL-SH)6 star polymers was linked via disulfide bond formation to l-cysteine to further demonstrate its reactivity.	Sulfhydryl Compounds	23-28	steroidogenic acute regulatory protein	Homo sapiens	66-70
34645263-5	2021	Then, the self-assembled DNA nanoprisms contained three thiols/hanging arms that could capture miRNA-210 efficiently and were anchored to the Fe3O4@CdS octahedra via the Cd-S bond.	Sulfhydryl Compounds	56-62	CDP-diacylglycerol synthase 1	Homo sapiens	170-174
34771233-7	2021	On the other hand, the thiol groups in the (PNVCL-SH)6 star polymers were easily transformed into trithiocarbonate groups by addition of CS2 followed by benzyl bromide as demonstrated by UV-Vis spectroscopical analysis and GPC.	Sulfhydryl Compounds	23-28	steroidogenic acute regulatory protein	Homo sapiens	55-59
34480371-0	2021	On-Surface Polymerization of In-Plane Highly Ordered Carbon Nitride Nanosheets toward Photocatalytic Mineralization of Mercaptan Gas.	Sulfhydryl Compounds	119-128	gastrin	Homo sapiens	129-132
34771233-7	2021	On the other hand, the thiol groups in the (PNVCL-SH)6 star polymers were easily transformed into trithiocarbonate groups by addition of CS2 followed by benzyl bromide as demonstrated by UV-Vis spectroscopical analysis and GPC.	Sulfhydryl Compounds	23-28	chorionic somatomammotropin hormone 2	Homo sapiens	137-140
34662529-7	2021	Direct thiol oxidation of key proteins such as ATG4, ATM and TFEB are responsible for specific regulations in phagophore expansion, cargo recognition and autophagy gene transcription, respectively.	Sulfhydryl Compounds	7-12	ATM serine/threonine kinase	Homo sapiens	53-56
34662529-7	2021	Direct thiol oxidation of key proteins such as ATG4, ATM and TFEB are responsible for specific regulations in phagophore expansion, cargo recognition and autophagy gene transcription, respectively.	Sulfhydryl Compounds	7-12	transcription factor EB	Homo sapiens	61-65
34679020-6	2021	Patulin-thiol co-treatment decreased CHOP expression and BiP and CHOP levels in HepG2 cells but did not alter BiP expression.	Sulfhydryl Compounds	8-13	DNA damage inducible transcript 3	Homo sapiens	37-41
34679020-6	2021	Patulin-thiol co-treatment decreased CHOP expression and BiP and CHOP levels in HepG2 cells but did not alter BiP expression.	Sulfhydryl Compounds	8-13	heat shock protein family A (Hsp70) member 5	Homo sapiens	57-60
34679020-6	2021	Patulin-thiol co-treatment decreased CHOP expression and BiP and CHOP levels in HepG2 cells but did not alter BiP expression.	Sulfhydryl Compounds	8-13	DNA damage inducible transcript 3	Homo sapiens	65-69
34679020-7	2021	Spliced XBP1 expression was decreased by patulin-thiol co-treatment.	Sulfhydryl Compounds	49-54	X-box binding protein 1	Homo sapiens	8-12
34760179-3	2021	The grand principles of supramolecular chemistry, that is the pH dependence of dynamic covalent disulfide exchange with known thiols on the transferrin receptor, are proposed to account for transcytosis into deep tissue, while the known but elusive exchange cascades along the same or other partners assure cytosolic delivery in kinetic competition.	Sulfhydryl Compounds	126-132	transferrin receptor	Homo sapiens	140-160
34627514-4	2021	Based on the fact that ALP can trigger the in-situ reaction between o-phenylenediamine (OPD) and ascorbic acid (AA), we connected gold nanoparticles (AuNPs) to 3,4-diaminobenzene-thiol (OPD(SH)) through an Au-S covalent bond to synthesize a nanoprobe (OPD(S)-AuNPs).	Sulfhydryl Compounds	179-184	alkaline phosphatase, placental	Homo sapiens	23-26
34712657-2	2021	Insulin-degrading enzyme (IDE), a thiol zinc-metalloendopeptidase, has been known to regulate the myogenic process of mouse and rat myoblast cell lines, while its myogenic role in pigs remained elusive.	Sulfhydryl Compounds	34-39	insulin degrading enzyme	Mus musculus	0-24
34712657-2	2021	Insulin-degrading enzyme (IDE), a thiol zinc-metalloendopeptidase, has been known to regulate the myogenic process of mouse and rat myoblast cell lines, while its myogenic role in pigs remained elusive.	Sulfhydryl Compounds	34-39	insulin degrading enzyme	Mus musculus	26-29
34712657-2	2021	Insulin-degrading enzyme (IDE), a thiol zinc-metalloendopeptidase, has been known to regulate the myogenic process of mouse and rat myoblast cell lines, while its myogenic role in pigs remained elusive.	Sulfhydryl Compounds	34-39	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10	Mus musculus	40-65
34418513-10	2021	After validating the assay principle (i.e., increased target specific reversible thiol oxidation increases the ratio), we used ALISA to determine whether fertilisation-a fundamental biological process-changes Akt, a serine/threonine protein kinase, specific reversible thiol oxidation.	Sulfhydryl Compounds	81-86	v-akt murine thymoma viral oncogene homolog 1 S homeolog	Xenopus laevis	209-212
34399322-6	2021	Furthermore, a molecular dynamic simulation of 11h was carried out to assess the stability to form a complex with the L858R/T790M EGFR Kinase domain, which demonstrated that complex was stable for the 100 ns and form strong crucial covalent binding contacts with the thiol group of Cys797 residue.	Sulfhydryl Compounds	267-272	epidermal growth factor receptor	Homo sapiens	130-134
34418513-10	2021	After validating the assay principle (i.e., increased target specific reversible thiol oxidation increases the ratio), we used ALISA to determine whether fertilisation-a fundamental biological process-changes Akt, a serine/threonine protein kinase, specific reversible thiol oxidation.	Sulfhydryl Compounds	269-274	v-akt murine thymoma viral oncogene homolog 1 S homeolog	Xenopus laevis	209-212
34418513-11	2021	Fertilisation significantly decreases Akt specific reversible thiol oxidation in Xenopus laevis 2-cell zygotes compared to unfertilised eggs.	Sulfhydryl Compounds	62-67	v-akt murine thymoma viral oncogene homolog 1 S homeolog	Xenopus laevis	38-41
34508780-1	2021	Cysteamine dioxygenase (ADO) plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis in humans by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate.	Sulfhydryl Compounds	62-67	2-aminoethanethiol dioxygenase	Homo sapiens	0-22
34347214-4	2021	It was also verified that the thiol-alkylating agent NEM prevented AdoMet-induced DeltaPsim dissipation, implying a role for thiol oxidation in the mPT pore opening.	Sulfhydryl Compounds	30-35	methionine adenosyltransferase 1A	Rattus norvegicus	67-73
34347214-4	2021	It was also verified that the thiol-alkylating agent NEM prevented AdoMet-induced DeltaPsim dissipation, implying a role for thiol oxidation in the mPT pore opening.	Sulfhydryl Compounds	125-130	methionine adenosyltransferase 1A	Rattus norvegicus	67-73
34508780-1	2021	Cysteamine dioxygenase (ADO) plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis in humans by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate.	Sulfhydryl Compounds	62-67	2-aminoethanethiol dioxygenase	Homo sapiens	24-27
34509915-0	2021	A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation.	Sulfhydryl Compounds	2-7	epoxide hydrolase 2, cytoplasmic	Mus musculus	24-49
34516111-1	2021	By facilitating the chemical conversion of thiols to thiosulfonates, phosphoramidite/phosphite bearing sp3-hybridized carbon serves as an ideal coupling material to forge new connections at room temperature.	Sulfhydryl Compounds	43-49	Sp3 transcription factor	Homo sapiens	103-106
34564928-0	2021	Thiol/disulfide homeostasis and its relationship with insulin resistance in patients with rosacea.	Sulfhydryl Compounds	0-5	insulin	Homo sapiens	54-61
34638573-9	2021	Biochemical interactions, such as the sensitivity of LOX toward thiol-reactive agents belonging to cyclopentenone prostaglandins, are suggested to occur in human LOX homologs.	Sulfhydryl Compounds	64-69	lysyl oxidase	Homo sapiens	53-56
34667943-1	2021	A flavin-dependent enzyme quiescin Q6 sulfhydryl oxidase 1 (QSOX1) catalyzes the oxidation of thiol groups into disulfide bonds.	Sulfhydryl Compounds	94-99	quiescin Q6 sulfhydryl oxidase 1	Mus musculus	26-58
34667943-1	2021	A flavin-dependent enzyme quiescin Q6 sulfhydryl oxidase 1 (QSOX1) catalyzes the oxidation of thiol groups into disulfide bonds.	Sulfhydryl Compounds	94-99	quiescin Q6 sulfhydryl oxidase 1	Mus musculus	60-65
34523686-1	2022	Thioredoxins, small disulphide-containing redox proteins, play an important role in the regulation of cellular thiol redox balance through their disulfide reductase activity.	Sulfhydryl Compounds	111-116	thioredoxin	Homo sapiens	0-12
34638573-9	2021	Biochemical interactions, such as the sensitivity of LOX toward thiol-reactive agents belonging to cyclopentenone prostaglandins, are suggested to occur in human LOX homologs.	Sulfhydryl Compounds	64-69	lysyl oxidase	Homo sapiens	162-165
34681298-2	2021	Bromelain is a complex combination of multiple endopeptidases of thiol and other compounds derived from the pineapple fruit, stem and/or root.	Sulfhydryl Compounds	65-70	TATA-binding protein-associated factor 2N-like	Ananas comosus	0-9
34517794-10	2022	CONCLUSION: Benzothiazole, benzoxazole, benzimidazole, and sulfhydryl derivatives stand out as TIM inhibitors.	Sulfhydryl Compounds	59-69	triosephosphate isomerase 1	Homo sapiens	95-98
34324984-5	2021	In this study, a LL-37 peptide fragment analog with cysteine at the N-terminus was conjugated with the biodegradable polymer, lactic acid/glycolic acid copolymer (PLGA), using the thiol group of cysteine.	Sulfhydryl Compounds	180-185	cathelicidin antimicrobial peptide	Homo sapiens	17-22
34499705-4	2021	Thiol crosslinked peptide binding to SLC4A11 was screened by untargeted liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis.	Sulfhydryl Compounds	0-5	solute carrier family 4 member 11	Homo sapiens	37-44
34476628-2	2021	The 2D Au@PdMo nanozymes possessed high-efficiency peroxidase-like activity and were assembled with an aptamer composed of a thiol-modified epithelial specific cell adhesion molecule (EpCAM) to strengthen CTCs adhesion.	Sulfhydryl Compounds	125-130	epithelial cell adhesion molecule	Homo sapiens	184-189
34274401-8	2021	The presence of disulfide linkages and thiol groups were shown to favor improved binding of cross-linked nanogels to mucin.	Sulfhydryl Compounds	39-44	LOC100508689	Homo sapiens	117-122
34500775-1	2021	Thioredoxin-interacting protein (TXNIP) is involved in multiple disease-associated functions related to oxidative stress, especially by inhibiting the anti-oxidant- and thiol-reducing activity of thioredoxin (TXN).	Sulfhydryl Compounds	169-174	thioredoxin interacting protein	Mus musculus	0-31
34500775-1	2021	Thioredoxin-interacting protein (TXNIP) is involved in multiple disease-associated functions related to oxidative stress, especially by inhibiting the anti-oxidant- and thiol-reducing activity of thioredoxin (TXN).	Sulfhydryl Compounds	169-174	thioredoxin interacting protein	Mus musculus	33-38
34500775-1	2021	Thioredoxin-interacting protein (TXNIP) is involved in multiple disease-associated functions related to oxidative stress, especially by inhibiting the anti-oxidant- and thiol-reducing activity of thioredoxin (TXN).	Sulfhydryl Compounds	169-174	thioredoxin 1	Mus musculus	196-207
34500775-1	2021	Thioredoxin-interacting protein (TXNIP) is involved in multiple disease-associated functions related to oxidative stress, especially by inhibiting the anti-oxidant- and thiol-reducing activity of thioredoxin (TXN).	Sulfhydryl Compounds	169-174	thioredoxin 1	Mus musculus	209-212
34331200-0	2021	Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2.	Sulfhydryl Compounds	43-48	heat shock protein 90 alpha family class A member 1	Homo sapiens	115-120
34331200-0	2021	Gambogic acid and gambogenic acid induce a thiol-dependent heat shock response and disrupt the interaction between HSP90 and HSF1 or HSF2.	Sulfhydryl Compounds	43-48	heat shock transcription factor 1	Homo sapiens	125-129
34331200-5	2021	In this study, we show that GB and a structurally related compound, called gambogenic acid (GBA), induce a robust HSR, in a thiol-dependent manner.	Sulfhydryl Compounds	124-129	glucosylceramidase beta	Homo sapiens	92-95
34415768-3	2021	In this study, we employed sensitive fluorescence depolarization kinetics by following picosecond time-resolved fluorescence anisotropy decays to directly capture the essential dynamical features of intrinsically disordered alpha-synuclein (alpha-syn) site-specifically labeled with thiol-active fluorophores.	Sulfhydryl Compounds	283-288	synuclein alpha	Homo sapiens	224-239
34415768-3	2021	In this study, we employed sensitive fluorescence depolarization kinetics by following picosecond time-resolved fluorescence anisotropy decays to directly capture the essential dynamical features of intrinsically disordered alpha-synuclein (alpha-syn) site-specifically labeled with thiol-active fluorophores.	Sulfhydryl Compounds	283-288	synuclein alpha	Homo sapiens	241-250
34286848-9	2021	CONCLUSION: The redox status of serum apoE-Cys-thiol is closely involved in the metabolism of TG-rich lipoproteins and glucose.	Sulfhydryl Compounds	47-52	apolipoprotein E	Homo sapiens	38-42
34339733-0	2021	A thiol-based intramolecular redox switch in four-repeat tau controls fibril assembly and disassembly.	Sulfhydryl Compounds	2-7	microtubule associated protein tau	Homo sapiens	57-60
34167028-0	2021	A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO  sabotage of theft-ferroptosis.	Sulfhydryl Compounds	6-11	inositol-3-phosphate synthase 1	Homo sapiens	93-97
34380308-5	2021	Mechanistic studies support the working model involving a thiol-catalyzed radical chain process wherein the atoms from formate are delivered across the alkene substrate via CO2 - as a key reactive intermediate.	Sulfhydryl Compounds	58-63	complement C2	Homo sapiens	173-176
34252541-8	2021	Furthermore, flow cytometry studies using a FITC-maleimide showed that the GPVI agonist CRP stimulated an increase in free thiols on the platelet outer membrane, which was inhibited by CxxCpep.	Sulfhydryl Compounds	123-129	glycoprotein VI platelet	Homo sapiens	75-79
34298537-2	2021	During the biosensor operation, thrombin and PDGF-BB in the sample were recognized and combined by thiol-modified aptamers immobilized on Au-Ag hollow nanoparticles (Au-Ag HNPs) surface and biotinylated aptamers immobilized on the test lines of the biosensor.	Sulfhydryl Compounds	99-104	coagulation factor II, thrombin	Homo sapiens	32-40
34292749-3	2021	The representative compound 4a was able to slowly generate low concentrations of NO2- by reaction with a thiol-containing nucleophile, and the NO2- was selectively converted into NO under ischemic/hypoxia conditions to protect primary rat neurons from oxygen-glucose deprivation and recovery (OGD/R)-induced cytotoxicity by enhancing the Nrf2 signaling and activating the NO/cGMP/PKG pathway.	Sulfhydryl Compounds	105-110	NFE2 like bZIP transcription factor 2	Rattus norvegicus	338-342
34439857-3	2021	Here, we report that the injection of exogenous recombinant mouse serum albumin (rMSA) reduced the total damages of serum albumin in C57BL/6N mice, with higher level of free-thiols, lower levels of carbonyls and advanced glycation end-products as well as homocysteines in rMSA-treated mice.	Sulfhydryl Compounds	174-180	albumin	Mus musculus	66-79
34439857-3	2021	Here, we report that the injection of exogenous recombinant mouse serum albumin (rMSA) reduced the total damages of serum albumin in C57BL/6N mice, with higher level of free-thiols, lower levels of carbonyls and advanced glycation end-products as well as homocysteines in rMSA-treated mice.	Sulfhydryl Compounds	174-180	albumin	Mus musculus	122-129
34379701-5	2021	RESULTS: Higher levels of free thiols at Day 1 and Day 5 are associated with higher mGFR at Day 5 (p<0.001, r2adj.	Sulfhydryl Compounds	31-37	Rap guanine nucleotide exchange factor (GEF) 5	Mus musculus	84-88
34439096-6	2021	Co-incubation with these thiol isomerase inhibitors prevented LPS-induced TF production by CD14-positive monocytes and constitutive TF expression by THP1 cells and AML blasts.	Sulfhydryl Compounds	25-30	CD14 molecule	Homo sapiens	91-95
34447788-0	2021	Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy.	Sulfhydryl Compounds	14-19	protein kinase C alpha	Homo sapiens	60-63
34447788-7	2021	We find that even in the presence of the oxygen-rich sites presented by the neighboring peripheral membrane-binding C2 domain, the thiol-rich sites can successfully compete for the available Cd2+.	Sulfhydryl Compounds	131-136	CD2 molecule	Homo sapiens	191-194
34447788-8	2021	Our results indicate that Cd2+ can target the entire membrane-binding regulatory region of PKCs, and that the competition between the thiol- and oxygen-rich sites will likely determine the activation pattern of PKCs.	Sulfhydryl Compounds	134-139	CD2 molecule	Homo sapiens	26-29
34350496-4	2022	To generate the SERS signal, the Au-Te nanostructure was immobilized on an indium-tin oxide substrate, and the thiol-modified CRP aptamer was then self-assembled onto the modified substrate for CRP recognition.	Sulfhydryl Compounds	111-116	C-reactive protein	Homo sapiens	126-129
34350496-4	2022	To generate the SERS signal, the Au-Te nanostructure was immobilized on an indium-tin oxide substrate, and the thiol-modified CRP aptamer was then self-assembled onto the modified substrate for CRP recognition.	Sulfhydryl Compounds	111-116	C-reactive protein	Homo sapiens	194-197
34439489-4	2021	One target of oxidants that has the potential to be harnessed as a clinical biomarker is the thiol side chain of cysteine 34 (Cys34) of the blood protein albumin.	Sulfhydryl Compounds	93-98	albumin	Mus musculus	154-161
34350692-2	2022	The synthesized compounds, especially 1-Pro-His, remarkably promoted S-denitrosylation of nitrosothiols (RSNO) via a catalytic cycle involving the reversible redox reaction between the diselenide and its corresponding diselenol ((SeH,SeH)) form with coexisting reductant thiols (R"SH), during which the (SeH,SeH) form as a key reactive species reduces RSNO to the corresponding thiol (RSH).	Sulfhydryl Compounds	271-277	epoxide hydrolase 2	Homo sapiens	230-233
34350692-2	2022	The synthesized compounds, especially 1-Pro-His, remarkably promoted S-denitrosylation of nitrosothiols (RSNO) via a catalytic cycle involving the reversible redox reaction between the diselenide and its corresponding diselenol ((SeH,SeH)) form with coexisting reductant thiols (R"SH), during which the (SeH,SeH) form as a key reactive species reduces RSNO to the corresponding thiol (RSH).	Sulfhydryl Compounds	271-277	epoxide hydrolase 2	Homo sapiens	234-237
34350692-2	2022	The synthesized compounds, especially 1-Pro-His, remarkably promoted S-denitrosylation of nitrosothiols (RSNO) via a catalytic cycle involving the reversible redox reaction between the diselenide and its corresponding diselenol ((SeH,SeH)) form with coexisting reductant thiols (R"SH), during which the (SeH,SeH) form as a key reactive species reduces RSNO to the corresponding thiol (RSH).	Sulfhydryl Compounds	271-277	epoxide hydrolase 2	Homo sapiens	304-307
34350692-2	2022	The synthesized compounds, especially 1-Pro-His, remarkably promoted S-denitrosylation of nitrosothiols (RSNO) via a catalytic cycle involving the reversible redox reaction between the diselenide and its corresponding diselenol ((SeH,SeH)) form with coexisting reductant thiols (R"SH), during which the (SeH,SeH) form as a key reactive species reduces RSNO to the corresponding thiol (RSH).	Sulfhydryl Compounds	271-277	epoxide hydrolase 2	Homo sapiens	308-311
34350692-2	2022	The synthesized compounds, especially 1-Pro-His, remarkably promoted S-denitrosylation of nitrosothiols (RSNO) via a catalytic cycle involving the reversible redox reaction between the diselenide and its corresponding diselenol ((SeH,SeH)) form with coexisting reductant thiols (R"SH), during which the (SeH,SeH) form as a key reactive species reduces RSNO to the corresponding thiol (RSH).	Sulfhydryl Compounds	378-383	epoxide hydrolase 2	Homo sapiens	230-233
34350692-2	2022	The synthesized compounds, especially 1-Pro-His, remarkably promoted S-denitrosylation of nitrosothiols (RSNO) via a catalytic cycle involving the reversible redox reaction between the diselenide and its corresponding diselenol ((SeH,SeH)) form with coexisting reductant thiols (R"SH), during which the (SeH,SeH) form as a key reactive species reduces RSNO to the corresponding thiol (RSH).	Sulfhydryl Compounds	378-383	epoxide hydrolase 2	Homo sapiens	234-237
34350692-2	2022	The synthesized compounds, especially 1-Pro-His, remarkably promoted S-denitrosylation of nitrosothiols (RSNO) via a catalytic cycle involving the reversible redox reaction between the diselenide and its corresponding diselenol ((SeH,SeH)) form with coexisting reductant thiols (R"SH), during which the (SeH,SeH) form as a key reactive species reduces RSNO to the corresponding thiol (RSH).	Sulfhydryl Compounds	378-383	epoxide hydrolase 2	Homo sapiens	304-307
34350692-2	2022	The synthesized compounds, especially 1-Pro-His, remarkably promoted S-denitrosylation of nitrosothiols (RSNO) via a catalytic cycle involving the reversible redox reaction between the diselenide and its corresponding diselenol ((SeH,SeH)) form with coexisting reductant thiols (R"SH), during which the (SeH,SeH) form as a key reactive species reduces RSNO to the corresponding thiol (RSH).	Sulfhydryl Compounds	378-383	epoxide hydrolase 2	Homo sapiens	308-311
34439489-8	2021	These data support the use of albumin thiol oxidation as a blood biomarker of dystropathology to assist with advancing clinical development of therapies for DMD.	Sulfhydryl Compounds	38-43	albumin	Mus musculus	30-37
34439489-5	2021	This study using the mdx mouse model of DMD shows that in plasma, albumin Cys34 undergoes thiol oxidation and these changes correlate with levels of protein thiol oxidation and damage of the dystrophic muscles.	Sulfhydryl Compounds	90-95	albumin	Mus musculus	66-73
34439489-5	2021	This study using the mdx mouse model of DMD shows that in plasma, albumin Cys34 undergoes thiol oxidation and these changes correlate with levels of protein thiol oxidation and damage of the dystrophic muscles.	Sulfhydryl Compounds	157-162	albumin	Mus musculus	66-73
34439489-6	2021	A comparison with the commonly used biomarker protein carbonylation, confirmed that albumin thiol oxidation is the more sensitive plasma biomarker of oxidative stress occurring in muscle tissue.	Sulfhydryl Compounds	92-97	albumin	Mus musculus	84-91
34215915-3	2021	SM reacts with endogenous human serum albumin (HSA adducts) alkylating the thiol group of the cysteine residue C34, thus causing the addition of the hydroxyethylthioethyl (HETE) moiety.	Sulfhydryl Compounds	75-80	albumin	Homo sapiens	38-45
34360775-12	2021	The changes are exemplified by the thiamine enhancement of the SIRT2 correlations with metabolic enzymes and proteins of thiol-disulfide metabolism.	Sulfhydryl Compounds	121-126	sirtuin 2	Rattus norvegicus	63-68
34275275-4	2021	Moreover, it was found that narrowband IR irradiation of the thiol-keto form in a neat solid, at the frequency of its CH stretching overtones/combination modes, also induces tautomerization to the thione-enol form.	Sulfhydryl Compounds	61-66	insulin receptor	Homo sapiens	39-41
34301493-1	2021	BACKGROUND/PURPOSE: The non-protein thiol glutathione is protective against infection by Mycobacterium tuberculosis (MTB) and, together with the transcription factor NRF2 (the nuclear factor erythroid 2-related factor 2), plays a crucial role in counteracting MTB-induced redox imbalance.	Sulfhydryl Compounds	36-41	NFE2 like bZIP transcription factor 2	Homo sapiens	166-170
34170111-7	2021	As a proof-of-concept application, the free-standing POD-like membranes were applied as a label-free assay in sensing cysteine, as well as monitoring acetylcholinesterase (AChE) activity through the generated thiol-containing product.	Sulfhydryl Compounds	209-214	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-170
34170111-7	2021	As a proof-of-concept application, the free-standing POD-like membranes were applied as a label-free assay in sensing cysteine, as well as monitoring acetylcholinesterase (AChE) activity through the generated thiol-containing product.	Sulfhydryl Compounds	209-214	acetylcholinesterase (Cartwright blood group)	Homo sapiens	172-176
34077868-0	2021	Inhibition of myeloid HDAC2 upregulates glutaredoxin 1 expression, improves protein thiol redox state and protects against high-calorie diet-induced monocyte dysfunction and atherosclerosis.	Sulfhydryl Compounds	84-89	histone deacetylase 2	Mus musculus	22-27
34132315-4	2021	Thiol-modified DNA chains were bonded to the surface of AuNCs by Au-S bonds, and an insulin aptamer was combined with the sulfhydryl chain to seal the AuNCs.	Sulfhydryl Compounds	0-5	insulin	Homo sapiens	84-91
34226580-0	2021	UV-induced Zn:Cd/S quantum dots in-situ formed in the presence of thiols for sensitive and selective fluorescence detection of thiols.	Sulfhydryl Compounds	66-72	CDP-diacylglycerol synthase 1	Homo sapiens	14-18
34226580-0	2021	UV-induced Zn:Cd/S quantum dots in-situ formed in the presence of thiols for sensitive and selective fluorescence detection of thiols.	Sulfhydryl Compounds	127-133	CDP-diacylglycerol synthase 1	Homo sapiens	14-18
34359447-1	2021	UV-B illumination facilitates aggregation of alpha-lactalbumin (alpha-LA) by intramolecular disulfide bond cleavage followed by intermolecular thiol-disulfide exchange reactions.	Sulfhydryl Compounds	143-148	lactalbumin alpha	Homo sapiens	45-62
34777608-3	2021	Methods: Here, we report Gal1 homodimers formed using an alternative thiol-Michael addition linker chemistry.	Sulfhydryl Compounds	69-74	galectin 1	Homo sapiens	25-29
34209102-2	2021	It can accomplish this even in the presence of highly efficient and abundant H2O2 scavengers, peroxiredoxins (Prdxs), as it is the Prdxs themselves that transfer oxidative equivalents to specific protein thiols on target proteins via their redox-relay functionality.	Sulfhydryl Compounds	204-210	peroxiredoxin 1	Homo sapiens	94-108
34190687-6	2021	These results underscore a membrane fusion mechanism that could be triggered by ERp57, allowing a thiol/disulfide exchange reaction to occur and regulate isomerization of a critical CSD, which ultimately leads to the exposition of the fusion peptide.	Sulfhydryl Compounds	98-103	protein disulfide isomerase family A member 3	Homo sapiens	80-85
34745555-3	2021	Herein, we describe the development of a highly stable and active immobilized PAL-biocatalyst obtained through site-specific covalent immobilization onto single-walled carbon nanotubes (SWCNTs), employing maleimide/thiol coupling of engineered enzymes containing surficial Cys residues.	Sulfhydryl Compounds	215-220	SHC binding and spindle associated 1	Homo sapiens	78-81
34133931-5	2021	ANAC089 truncated mutants exhibit higher NO and lower ROS and ABA endogenous levels, alongside an altered thiol and disulfide homeostasis.	Sulfhydryl Compounds	106-111	NAC domain containing protein 89	Arabidopsis thaliana	0-7
34098868-8	2021	Mild oxidation forming a C23-C45 disulfide bond, while leaving C106 with a thiol group, was required for HMGB1 to induce phosphorylated NF-KB p65 subunit and TNF-alpha production.	Sulfhydryl Compounds	75-80	high mobility group box 1	Mus musculus	105-110
34098868-8	2021	Mild oxidation forming a C23-C45 disulfide bond, while leaving C106 with a thiol group, was required for HMGB1 to induce phosphorylated NF-KB p65 subunit and TNF-alpha production.	Sulfhydryl Compounds	75-80	tumor necrosis factor	Mus musculus	158-167
34777608-11	2021	Conclusion: Collectively, these data demonstrate that thiol-Michael addition bioconjugation leads to a PEG-cross-linked Gal1 homodimer with improved extracellular signaling activity that does not require a reducing environment to be functional.	Sulfhydryl Compounds	54-59	galectin 1	Homo sapiens	120-124
34063668-2	2021	In this study, in vitro assays showed that SME inhibits glycation, carbonyl groups formation, and reduced-thiol groups depletion in bovine serum albumin incubated either reducing sugars or methylglyoxal.	Sulfhydryl Compounds	106-111	albumin	Rattus norvegicus	139-152
34070648-3	2021	Specific chemical functionalities (-COO, -NH2 and -S) on the thiol precursor (L-cysteine ethyl ester) were clicked directly on the sp2 carbon of graphene framework with grafting density of 1 unit L-cysteine per 113 carbon atoms on graphene.	Sulfhydryl Compounds	61-66	Sp2 transcription factor	Homo sapiens	131-134
34164056-7	2021	Crystal structures of MMTZ complexes reveal similar binding patterns to the most clinically important B1 MBLs (NDM-1, VIM-2 and IMP-1), contrasting with previously studied thiol-based MBL inhibitors, such as bisthiazolidines (BTZs) or captopril stereoisomers, which exhibit lower, more variable potencies and multiple binding modes.	Sulfhydryl Compounds	172-177	mannose-binding lectin family member 3, pseudogene	Homo sapiens	184-187
34744411-6	2021	At pH<7, ASH, like GSH, interacts with H2O2 to form thiyl radicals, which initiate thiol-ene reactions with unsaturated phenol resveratrol.	Sulfhydryl Compounds	83-88	arylsulfatase family member H	Homo sapiens	9-12
34955553-4	2021	Due to the thiol group of Cys34, albumin can serve as a trap for reactive oxygen and nitrogen species, thus participating in redox processes.	Sulfhydryl Compounds	11-16	albumin	Homo sapiens	33-40
35596011-7	2022	Here, we demonstrate that this prepared catalyst could be used to simultaneously determine a variety of major known physiologically relevant thiol-containing and thiol-free antioxidants, accompanied by a blue color gradient change with UV-Vis spectra at 652 nm through the SA-Pd/NPC-catalyzed TMB-H2O2 system.	Sulfhydryl Compounds	141-146	NPC intracellular cholesterol transporter 1	Homo sapiens	273-282
35462248-2	2022	For this purpose, the thrombin imprinted and non-imprinted SPR biosensors were prepared by integrating the synthesized thrombin imprinted and non-imprinted nanoparticles on the allyl mercaptan modified gold SPR chip surface.	Sulfhydryl Compounds	183-192	coagulation factor II, thrombin	Homo sapiens	22-30
35462248-2	2022	For this purpose, the thrombin imprinted and non-imprinted SPR biosensors were prepared by integrating the synthesized thrombin imprinted and non-imprinted nanoparticles on the allyl mercaptan modified gold SPR chip surface.	Sulfhydryl Compounds	183-192	coagulation factor II, thrombin	Homo sapiens	119-127
35583462-2	2022	Considering cooperative coordination of a multivalent thiol-pendant polypeptide ligand with iron ions, we put forward a facile strategy for constructing the iron-coordinated nanohybrid of methacryloyloxyethyl phosphorylcholine-grafted polycysteine/iron ions/tannic acid (i.e., PCFT), which could deliver a higher concentration of iron ions into cells.	Sulfhydryl Compounds	54-59	solute carrier family 46 member 1	Homo sapiens	277-281
35596011-7	2022	Here, we demonstrate that this prepared catalyst could be used to simultaneously determine a variety of major known physiologically relevant thiol-containing and thiol-free antioxidants, accompanied by a blue color gradient change with UV-Vis spectra at 652 nm through the SA-Pd/NPC-catalyzed TMB-H2O2 system.	Sulfhydryl Compounds	162-167	NPC intracellular cholesterol transporter 1	Homo sapiens	273-282
35468173-3	2022	Specifically, graphite carbon nitride (g-C3N4) as an effective ECL luminescent substrate and Au nanoparticles were sequentially assembled on the Au electrode surface, and then a thiol-modified aptamer for capturing Abeta peptide was attached to the surface of the electrode through the Au-S bond.	Sulfhydryl Compounds	178-183	amyloid beta precursor protein	Homo sapiens	215-220
35624568-8	2022	An identical response was observed for other low molecular weight thiols, while larger macromolecules with free thiol groups (e.g., bovine serum albumin) do not produce distinguishable spectral alterations.	Sulfhydryl Compounds	112-117	albumin	Homo sapiens	139-152
35571249-7	2022	Mechanistically, we found that H2S persulfidated caspase-3 in H9C2 cells and human recombinant caspase-3 protein, while the thiol-reducing agent dithiothreitol (DTT) abolished H2S-induced persulfidation of caspase-3 and thereby prevented the antiapoptotic effect of H2S on caspase-3 in H9C2 cells.	Sulfhydryl Compounds	124-129	caspase 3	Homo sapiens	206-215
35571249-7	2022	Mechanistically, we found that H2S persulfidated caspase-3 in H9C2 cells and human recombinant caspase-3 protein, while the thiol-reducing agent dithiothreitol (DTT) abolished H2S-induced persulfidation of caspase-3 and thereby prevented the antiapoptotic effect of H2S on caspase-3 in H9C2 cells.	Sulfhydryl Compounds	124-129	caspase 3	Homo sapiens	273-282
34541904-4	2022	Thiol-based antioxidant systems such as the Thioredoxin/Thioredoxin reductase (Trx/TrxR) and Glutathione/Glutaredoxin (GSH/Grx) are continually active in cancer cells, while the Thioredoxin-interacting protein (Txnip), the negative regulator of the Trx/TrxR system, is down regulated.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	44-55
34541904-4	2022	Thiol-based antioxidant systems such as the Thioredoxin/Thioredoxin reductase (Trx/TrxR) and Glutathione/Glutaredoxin (GSH/Grx) are continually active in cancer cells, while the Thioredoxin-interacting protein (Txnip), the negative regulator of the Trx/TrxR system, is down regulated.	Sulfhydryl Compounds	0-5	peroxiredoxin 5	Homo sapiens	56-77
34541904-4	2022	Thiol-based antioxidant systems such as the Thioredoxin/Thioredoxin reductase (Trx/TrxR) and Glutathione/Glutaredoxin (GSH/Grx) are continually active in cancer cells, while the Thioredoxin-interacting protein (Txnip), the negative regulator of the Trx/TrxR system, is down regulated.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	79-82
34541904-4	2022	Thiol-based antioxidant systems such as the Thioredoxin/Thioredoxin reductase (Trx/TrxR) and Glutathione/Glutaredoxin (GSH/Grx) are continually active in cancer cells, while the Thioredoxin-interacting protein (Txnip), the negative regulator of the Trx/TrxR system, is down regulated.	Sulfhydryl Compounds	0-5	glutaredoxin	Homo sapiens	105-117
34541904-4	2022	Thiol-based antioxidant systems such as the Thioredoxin/Thioredoxin reductase (Trx/TrxR) and Glutathione/Glutaredoxin (GSH/Grx) are continually active in cancer cells, while the Thioredoxin-interacting protein (Txnip), the negative regulator of the Trx/TrxR system, is down regulated.	Sulfhydryl Compounds	0-5	glutaredoxin	Homo sapiens	123-126
34541904-4	2022	Thiol-based antioxidant systems such as the Thioredoxin/Thioredoxin reductase (Trx/TrxR) and Glutathione/Glutaredoxin (GSH/Grx) are continually active in cancer cells, while the Thioredoxin-interacting protein (Txnip), the negative regulator of the Trx/TrxR system, is down regulated.	Sulfhydryl Compounds	0-5	thioredoxin interacting protein	Homo sapiens	178-209
34541904-4	2022	Thiol-based antioxidant systems such as the Thioredoxin/Thioredoxin reductase (Trx/TrxR) and Glutathione/Glutaredoxin (GSH/Grx) are continually active in cancer cells, while the Thioredoxin-interacting protein (Txnip), the negative regulator of the Trx/TrxR system, is down regulated.	Sulfhydryl Compounds	0-5	thioredoxin interacting protein	Homo sapiens	211-216
34541904-4	2022	Thiol-based antioxidant systems such as the Thioredoxin/Thioredoxin reductase (Trx/TrxR) and Glutathione/Glutaredoxin (GSH/Grx) are continually active in cancer cells, while the Thioredoxin-interacting protein (Txnip), the negative regulator of the Trx/TrxR system, is down regulated.	Sulfhydryl Compounds	0-5	thioredoxin	Homo sapiens	249-252
35483566-8	2022	Accordingly, Thiol/Disulfide balance (Disulfide (DS)/Native Thiol (NT), DS/Total Thiol (TT)), Total Oxidative Stress (TOS), Oxidative Stress Index (OSI), and Nuclear Factor Erythroid-2 Associated Factor-2 (Nrf2) values were used as the biochemical parameters indicating an increase in the serum oxidative stress level.	Sulfhydryl Compounds	13-18	NFE2 like bZIP transcription factor 2	Homo sapiens	158-204
35483566-8	2022	Accordingly, Thiol/Disulfide balance (Disulfide (DS)/Native Thiol (NT), DS/Total Thiol (TT)), Total Oxidative Stress (TOS), Oxidative Stress Index (OSI), and Nuclear Factor Erythroid-2 Associated Factor-2 (Nrf2) values were used as the biochemical parameters indicating an increase in the serum oxidative stress level.	Sulfhydryl Compounds	13-18	NFE2 like bZIP transcription factor 2	Homo sapiens	206-210
35507055-6	2022	And transgenic lines decreased in the level of endogenous H2S, L-cysteine desulfurase 1 (des1) mutant and 35S::GFP-O-acetyl-L-serine(thiol)lyase A1 (OASA1)/des1-#56/#61, were sensitive to submergence, along with the lower transcript levels of hypoxia response genes, LOB DOMAIN 41 (LBD41) and HYPOXIA RESPONSIVE UNKNOWN PROTEIN 43 (HUP43).	Sulfhydryl Compounds	133-138	LOB domain-containing protein 41	Arabidopsis thaliana	267-280
35507055-6	2022	And transgenic lines decreased in the level of endogenous H2S, L-cysteine desulfurase 1 (des1) mutant and 35S::GFP-O-acetyl-L-serine(thiol)lyase A1 (OASA1)/des1-#56/#61, were sensitive to submergence, along with the lower transcript levels of hypoxia response genes, LOB DOMAIN 41 (LBD41) and HYPOXIA RESPONSIVE UNKNOWN PROTEIN 43 (HUP43).	Sulfhydryl Compounds	133-138	LOB domain-containing protein 41	Arabidopsis thaliana	282-287
35491240-5	2022	EXPERIMENTAL APPROACH: Heterozygous SERCA2 C674S knock-in (SKI) mice, in which half of C674 was replaced by serine, were used to mimic partially irreversible oxidation of C674 thiol.	Sulfhydryl Compounds	176-181	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	36-42
35491240-5	2022	EXPERIMENTAL APPROACH: Heterozygous SERCA2 C674S knock-in (SKI) mice, in which half of C674 was replaced by serine, were used to mimic partially irreversible oxidation of C674 thiol.	Sulfhydryl Compounds	176-181	ski sarcoma viral oncogene homolog (avian)	Mus musculus	59-62
35564130-2	2022	In this report, we present the thermo-responsive assembly and thermo-dynamic behavior of AuNDs functionalized with methyl-hexa(ethylene glycol) undecane-thiol as a thermo-responsive ligand.	Sulfhydryl Compounds	153-158	hexosaminidase subunit alpha	Homo sapiens	122-126
35566865-0	2022	A Study on the Dual Thermo- and pH-Responsive Behaviors of Well-Defined Star-like Block Copolymers Synthesize by Combining of RAFT Polymerization and Thiol-Ene Click Reaction.	Sulfhydryl Compounds	150-155	steroidogenic acute regulatory protein	Homo sapiens	72-76
35139422-4	2022	TGF-beta1 treatment increased both intra- and extracellular ROS generation along with NOX4 expression and reduced GPX and catalase activities, extracellular H2O2 scavenging capacity, and reduced thiol content.	Sulfhydryl Compounds	195-200	transforming growth factor, beta 1	Rattus norvegicus	0-9
35624664-11	2022	A multivariate regression analysis revealed an independent association of plasma free thiols at the ED (OR 0.52 per SD (0.29-0.93, 95% CI), p = 0.028) with MAKE365, even after adjustments for age, eGFR at the ED, SOFA score, and cardiovascular disease.	Sulfhydryl Compounds	86-92	epidermal growth factor receptor	Homo sapiens	197-201
35319066-6	2022	Second, we have established that in experimental conditions in which the sulfhydryl arylation by menadione or plumbagin is prevented by the thiol reducing agent N-acetyl-L-cysteine, the inhibition of Sirtuin 7 catalytic activity is also prevented.	Sulfhydryl Compounds	140-145	sirtuin 7	Homo sapiens	200-209
35378954-7	2022	Results: The study have demonstrated that modifications of salivary proteins increase with age, as manifested by decreased total thiol levels and increased carbonyl groups, glycation (Nepsilon-(carboxymethyl) lysine, advanced glycation end products (AGE)) and carbamylation (carbamyl-lysine) protein products in the saliva of old individuals.	Sulfhydryl Compounds	129-134	renin binding protein	Homo sapiens	91-94
35311249-5	2022	In detection process of the sandwich-type electrochemical immunosensor, glassy carbon electrode (GCE) was modified with 2D COFTab-Dva first then connected with Ab1 by the thiol-ene "click" reaction, next quantitative CEA was captured, followed by specificially capturing signal probe of Ab2/AuNPs/COFTFPB-Thi where AuNPs acted as nanocarriers of Ab2 and COFTFPB-Thi served as the signal producers.	Sulfhydryl Compounds	171-176	CEA cell adhesion molecule 3	Homo sapiens	217-220
35332570-0	2022	Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3beta/Fyn-dependent Nrf2 activation.	Sulfhydryl Compounds	80-85	glycogen synthase kinase 3 alpha	Mus musculus	114-122
35332570-0	2022	Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3beta/Fyn-dependent Nrf2 activation.	Sulfhydryl Compounds	80-85	Fyn proto-oncogene	Mus musculus	123-126
35332570-0	2022	Alpinetin inhibits macrophage infiltration and atherosclerosis by improving the thiol redox state: Requirement of GSk3beta/Fyn-dependent Nrf2 activation.	Sulfhydryl Compounds	80-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
35332570-8	2022	Data further showed that alpinetin reduced reactive oxygen species generation and promoted thiol-dependent glutathione and thioredoxin antioxidant systems in macrophages.	Sulfhydryl Compounds	91-96	thioredoxin 1	Mus musculus	123-134
35404520-0	2022	Synthesis and structure-activity relationship of thiol-based histone deacetylase 6 inhibitors.	Sulfhydryl Compounds	49-54	histone deacetylase 6	Homo sapiens	61-82
35404520-3	2022	Therefore, we designed and synthesized a series of selective HDAC6 inhibitors utilizing thiol as the ZBG and discussed their structure-activity relationship based on molecular docking.	Sulfhydryl Compounds	88-93	histone deacetylase 6	Homo sapiens	61-66
35404520-5	2022	Utilizing pyrimidine as a linker in thiol-based HDAC6 inhibitors produces an utterly novel structure, which might display different pharmacokinetic properties and genotoxicity.	Sulfhydryl Compounds	36-41	histone deacetylase 6	Homo sapiens	48-53
35253431-2	2022	Here, we report a novel prodrug, TC-D-F07, in which a thiol-reactive dinitrobenzenesulfonyl (Dns) cage was installed onto the C8 hydroxyl of the covalent IRE-1 inhibitor D-F07.	Sulfhydryl Compounds	54-59	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	154-159
35362647-2	2022	A low-affinity PD-1 binder was incubated with a library of >100 D-peptides under thiol-exchange favoring conditions, in the presence of the target protein PD-1, and we determined the S-linked dimeric species that resulted amplified in the protein samples versus the controls.	Sulfhydryl Compounds	81-86	programmed cell death 1	Homo sapiens	15-19
35078237-4	2022	Here, we observed root growth impairment in Arabidopsis thaliana mutants of mitochondrial alternative oxidase 1a (aox1a) in response to the model thiol reductant dithiothreitol (DTT).	Sulfhydryl Compounds	146-151	alternative oxidase 1A	Arabidopsis thaliana	114-119
35300941-2	2022	The studies describe the quantification of thiols in tissues and purified proteins using DTNB (Ellman"s Reagent).	Sulfhydryl Compounds	43-49	dystrobrevin beta	Homo sapiens	89-93
35456546-4	2022	The Lys-PCLA bioconjugates are prepared using thiol-ene reaction between thiolated lysozyme (Lys-SH) and acrylated PCLA (PCLA-Ac).	Sulfhydryl Compounds	46-51	lysozyme	Homo sapiens	83-91
35382274-1	2022	Amyloid beta (Abeta) peptides mutated at different positions using a cysteine moiety assemble on Au electrodes using the thiol functionality of cysteine.	Sulfhydryl Compounds	121-126	amyloid beta precursor protein	Homo sapiens	0-12
35382274-1	2022	Amyloid beta (Abeta) peptides mutated at different positions using a cysteine moiety assemble on Au electrodes using the thiol functionality of cysteine.	Sulfhydryl Compounds	121-126	amyloid beta precursor protein	Homo sapiens	14-19
35199805-11	2022	In addition, we applied this approach to study the process of a thiol exchange between molecules of triarylmethyl-labeled and 19F-labeled human serum albumin (HSA).	Sulfhydryl Compounds	64-69	albumin	Homo sapiens	144-157
35020395-2	2022	Herein, we introduce a per-/polyfluoroaryl moiety, which serves as a redox-active scaffold, into sp3-hybridized thiols to activate the C-S bond.	Sulfhydryl Compounds	112-118	Sp3 transcription factor	Homo sapiens	97-100
35335708-5	2022	Thereby, CNF/silica hydrogels bearing carboxyl groups and thiol groups were produced and tested as adsorber materials for heavy metals and dyes.	Sulfhydryl Compounds	58-63	NPHS1 adhesion molecule, nephrin	Homo sapiens	9-12
35321327-7	2022	Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1.	Sulfhydryl Compounds	81-86	conserved helix-loop-helix ubiquitous kinase	Mus musculus	129-142
35321327-7	2022	Furthermore, DCL-mediated actions were abolished by dithiothreitol, suggesting a thiol-mediated covalent linkage between DCL and IKKalpha/beta or Keap1.	Sulfhydryl Compounds	81-86	kelch-like ECH-associated protein 1	Mus musculus	146-151
35166114-5	2022	Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs.	Sulfhydryl Compounds	91-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	276-296
35166114-5	2022	Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs.	Sulfhydryl Compounds	91-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	298-302
35133140-1	2022	Thioredoxin (Trx) is one of the major thiol-dependent antioxidants in living systems.	Sulfhydryl Compounds	38-43	thioredoxin	Homo sapiens	0-11
35166114-5	2022	Interestingly, the 2D CMNSs with peroxidase-like properties exhibited a unique response to thiol compounds and were thus employed as highly efficient catalysts to develop HEC sensors for OPs based on the hydrolysis of acetylthiocholine (ATCh) to form thiocholine catalyzed by acetylcholinesterase (AChE) and the inhibition of AChE activity by OPs.	Sulfhydryl Compounds	91-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	326-330
35133140-1	2022	Thioredoxin (Trx) is one of the major thiol-dependent antioxidants in living systems.	Sulfhydryl Compounds	38-43	thioredoxin	Homo sapiens	13-16
35179864-3	2022	Intracellular antioxidant proteins, such as thioredoxin 1 (Trx1) and peroxiredoxin 1 (Prx1), could regulate redox homeostasis through thiol-disulfide exchange.	Sulfhydryl Compounds	134-139	thioredoxin	Homo sapiens	44-57
35179864-3	2022	Intracellular antioxidant proteins, such as thioredoxin 1 (Trx1) and peroxiredoxin 1 (Prx1), could regulate redox homeostasis through thiol-disulfide exchange.	Sulfhydryl Compounds	134-139	thioredoxin	Homo sapiens	59-63
35179864-3	2022	Intracellular antioxidant proteins, such as thioredoxin 1 (Trx1) and peroxiredoxin 1 (Prx1), could regulate redox homeostasis through thiol-disulfide exchange.	Sulfhydryl Compounds	134-139	peroxiredoxin 1	Homo sapiens	69-84
35179864-3	2022	Intracellular antioxidant proteins, such as thioredoxin 1 (Trx1) and peroxiredoxin 1 (Prx1), could regulate redox homeostasis through thiol-disulfide exchange.	Sulfhydryl Compounds	134-139	peroxiredoxin 1	Homo sapiens	86-90
35217176-0	2022	Exercise decreases PP2A-specific reversible thiol oxidation in human erythrocytes: Implications for redox biomarkers.	Sulfhydryl Compounds	44-49	protein phosphatase 2 phosphatase activator	Homo sapiens	19-23
35131446-7	2022	Specifically, LPS increased PP2A-, SHP1-, PTP1B-, and CD45-specific reversible thiol oxidation without changing the redox state of calcineurin, PTEN, and SHP2.	Sulfhydryl Compounds	79-84	protein phosphatase 2 phosphatase activator	Homo sapiens	28-32
35217176-5	2022	Unexpectedly, an acute bout of maximal exercise lasting ~16 min decreased PP2A-specific reversible thiol oxidation (redox ratio, rest: 0.46; exercise: 0.33) without changing PP2A content (rest: 193 pg/ml; exercise: 191 pg/ml).	Sulfhydryl Compounds	99-104	protein phosphatase 2 phosphatase activator	Homo sapiens	74-78
35131446-7	2022	Specifically, LPS increased PP2A-, SHP1-, PTP1B-, and CD45-specific reversible thiol oxidation without changing the redox state of calcineurin, PTEN, and SHP2.	Sulfhydryl Compounds	79-84	nuclear receptor subfamily 0 group B member 2	Homo sapiens	35-39
35217176-6	2022	The need for only 3-4 mul of sample to perform ALISA means PP2A-specific reversible thiol oxidation is a capillary-fingertip blood-compatible candidate redox biomarker.	Sulfhydryl Compounds	84-89	protein phosphatase 2 phosphatase activator	Homo sapiens	59-63
35131446-7	2022	Specifically, LPS increased PP2A-, SHP1-, PTP1B-, and CD45-specific reversible thiol oxidation without changing the redox state of calcineurin, PTEN, and SHP2.	Sulfhydryl Compounds	79-84	protein tyrosine phosphatase receptor type C	Homo sapiens	54-58
35217176-7	2022	Consistent with biologically meaningful redox regulation, thiol reductant-inducible PP2A activity was significantly greater (+10%) at rest compared to exercise.	Sulfhydryl Compounds	58-63	protein phosphatase 2 phosphatase activator	Homo sapiens	84-88
35104142-2	2022	Insulin-Fc conjugates were synthesized using trifunctional linkers with one amino reactive group for reaction with a lysine residue of insulin and two thiol reactive groups used for re-bridging of a disulfide bond within the Fc molecule.	Sulfhydryl Compounds	151-156	insulin	Homo sapiens	0-7
34982186-10	2022	On the other hand, Vit D alleviated AChE activity and MDA level, whereas increased SOD activity and thiol content in the hippocampal and cortical tissues.	Sulfhydryl Compounds	100-105	vitrin	Rattus norvegicus	19-22
35129956-0	2022	Albumin Biomolecular Drug Designs Stabilized through Improved Thiol Conjugation and a Modular Locked Nucleic Acid Functionalized Assembly.	Sulfhydryl Compounds	62-67	albumin	Homo sapiens	0-7
35252112-4	2022	In this study, we developed a method combining thiol labeling by monobromo(trimethylammonio)bimane bromide (qBBr) with AF4-FluoD to determine the size distribution and the quantities of thiols in the macromolecular dissolved organic matter (DOM) present in highly colored DOM-rich water sampled from Shuya River and Lake Onego, Russia.	Sulfhydryl Compounds	47-52	AF4/FMR2 family member 1	Homo sapiens	119-122
35252112-4	2022	In this study, we developed a method combining thiol labeling by monobromo(trimethylammonio)bimane bromide (qBBr) with AF4-FluoD to determine the size distribution and the quantities of thiols in the macromolecular dissolved organic matter (DOM) present in highly colored DOM-rich water sampled from Shuya River and Lake Onego, Russia.	Sulfhydryl Compounds	186-192	AF4/FMR2 family member 1	Homo sapiens	119-122
35252112-11	2022	In addition, to provide information on the dispersion of macromolecular thiols in colored DOM-rich natural water, our study also illustrated the potential of AF4-FluoD-UVD-ICP-MS to trace or quantify dynamic changes while Hg binds to the natural nano-colloidal components of surface water.	Sulfhydryl Compounds	72-78	AF4/FMR2 family member 1	Homo sapiens	158-161
35209089-1	2022	S-nitrosothiols are labile thiol-NO adducts formed in vivo primarily by metalloproteins such as NO synthase, ceruloplasmin, and hemoglobin.	Sulfhydryl Compounds	27-32	ceruloplasmin	Homo sapiens	109-122
35145079-2	2022	We report that in chow-fed, reproductively senescent female mice but not in age-matched male mice, deficiency in the thiol transferase glutaredoxin 1 (Grx1) promotes dysregulated macrophage phenotypes as well as rapid weight gain and atherogenesis.	Sulfhydryl Compounds	117-122	glutaredoxin	Mus musculus	135-149
35145079-2	2022	We report that in chow-fed, reproductively senescent female mice but not in age-matched male mice, deficiency in the thiol transferase glutaredoxin 1 (Grx1) promotes dysregulated macrophage phenotypes as well as rapid weight gain and atherogenesis.	Sulfhydryl Compounds	117-122	glutaredoxin	Mus musculus	151-155
35133130-3	2022	As evidenced by agarose gel electrophoresis and liquid chromatography-mass spectrometry, it could realize the fluorescent labeling of human serum albumin (HSA) through a thiol-cyanimide addition.	Sulfhydryl Compounds	170-175	albumin	Homo sapiens	140-153
35080855-6	2022	Optimized reaction conditions yield 15 copies of the anti-HIF-1-alpha ASO DNA covalently conjugated to the thiolated phospholipids using maleimide-thiol chemistry.	Sulfhydryl Compounds	147-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	58-69
35123263-0	2022	The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione.	Sulfhydryl Compounds	119-124	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	27-32
35123263-5	2022	Consistently, in vitro binding of RBD and ACE2, spike-mediated cell-cell fusion, and pseudotyped viral infection of VeroE6/TMPRSS2 cells were inhibited by the thiol-reactive compounds N-acetylcysteine (NAC) and a reduced form of glutathione (GSH).	Sulfhydryl Compounds	159-164	angiotensin-converting enzyme 2	Chlorocebus sabaeus	42-46
35123263-5	2022	Consistently, in vitro binding of RBD and ACE2, spike-mediated cell-cell fusion, and pseudotyped viral infection of VeroE6/TMPRSS2 cells were inhibited by the thiol-reactive compounds N-acetylcysteine (NAC) and a reduced form of glutathione (GSH).	Sulfhydryl Compounds	159-164	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53
35123263-5	2022	Consistently, in vitro binding of RBD and ACE2, spike-mediated cell-cell fusion, and pseudotyped viral infection of VeroE6/TMPRSS2 cells were inhibited by the thiol-reactive compounds N-acetylcysteine (NAC) and a reduced form of glutathione (GSH).	Sulfhydryl Compounds	159-164	transmembrane protease serine 2	Chlorocebus sabaeus	123-130
35061788-11	2022	Thiol content decreased only for glycated lysozyme and saliva with MGO.	Sulfhydryl Compounds	0-5	lysozyme	Homo sapiens	42-50
35014648-3	2022	In this study, an injectable disulfide-cross-linked chitosan hydrogel loaded with bFGF was prepared via a thiol-disulfide exchange reaction for MI treatment.	Sulfhydryl Compounds	106-111	fibroblast growth factor 2	Rattus norvegicus	82-86
34623443-10	2022	We discovered that the phenotypic rescue of ntrc by pgr5 is caused by the partial restoration of Trx-dependent reduction of thiol enzymes during the induction of photosynthesis.	Sulfhydryl Compounds	124-129	proton gradient regulation 5	Arabidopsis thaliana	52-56
34623443-10	2022	We discovered that the phenotypic rescue of ntrc by pgr5 is caused by the partial restoration of Trx-dependent reduction of thiol enzymes during the induction of photosynthesis.	Sulfhydryl Compounds	124-129	thioredoxin H-type 1	Arabidopsis thaliana	97-100
35317221-3	2022	Herein, a redox-triggered self-immolative NO prodrug that can be readily conjugated to various materials containing free thiol groups such as albumin, is reported.	Sulfhydryl Compounds	121-126	albumin	Homo sapiens	142-149
34982530-3	2022	Here, the response of the composition, structure, and electrochemical performance of EABs to the selective adhesion pressure due to the selective coordination of Fe(III) and Co(II) with thiol and the different affinities for bacteria on hybrid electrodes (Fe1Co, Fe4Co, and Fe10Co) were comprehensively investigated.	Sulfhydryl Compounds	186-191	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	174-180
35054674-6	2022	Once implemented, the thiol-disulfide exchange allowed the hydrogel dots to successfully capture and release the protein bovine serum albumin (BSA).	Sulfhydryl Compounds	22-27	albumin	Homo sapiens	128-141
34969852-8	2022	Altogether, Sod1-derived H2O2 is important for antioxidant defense and a master regulator of metabolism and the thiol redoxome.	Sulfhydryl Compounds	112-117	superoxide dismutase 1	Homo sapiens	12-16
34969852-0	2022	Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome.	Sulfhydryl Compounds	79-84	superoxide dismutase 1	Homo sapiens	0-4
35224969-4	2022	ADH also contains reactive electrophilic groups that allowed its efficient modification to functionalized polypeptides after reactions under mild conditions with thiol and amine nucleophiles.	Sulfhydryl Compounds	162-167	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	0-3
35101206-4	2022	The successful measurement of xCT requires non-denaturing western blotting of xCT subunits, while its activity is determined by the measurement of reduced thiol groups that accumulate over time, as determined by Ellman"s reagent.	Sulfhydryl Compounds	155-160	solute carrier family 7 member 11	Homo sapiens	30-33