PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21040737-5	2011	Furthermore, apigenin, kaempferol, chrysin, and flavone significantly inhibited HG plus TNFalpha-induced LOX-1 expression.	flavone	48-55	tumor necrosis factor	Homo sapiens	88-96
21040737-5	2011	Furthermore, apigenin, kaempferol, chrysin, and flavone significantly inhibited HG plus TNFalpha-induced LOX-1 expression.	flavone	48-55	oxidized low density lipoprotein receptor 1	Homo sapiens	105-110
21040737-6	2011	The inhibition of LOX-1 expression by apigenin was found to require a flavone skeleton, the double bond found in its C-ring, and the absence of a third hydroxyl group from its B- and C-rings.	flavone	70-77	oxidized low density lipoprotein receptor 1	Homo sapiens	18-23
21366040-3	2011	Flavone-based aromatase inhibitors are of growing interest, and chrysin in particular provides a (natural) lead structure.	flavone	0-7	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	14-23
21366040-6	2011	Similarly, the reaction of chrysin with various isonitriles and acetylene dicarboxylates results in a new class of flavone derivatives, tricyclic pyrano-flavones which also inhibit human aromatase.	flavone	115-122	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	187-196
20854805-5	2010	We found that PD98059 (2"-amino-3"-methoxyflavone), a flavone derivative and a selective MEK inhibitor, can dramatically block the cell killing effect of NSC-741909.	flavone	42-49	mitogen-activated protein kinase kinase 7	Homo sapiens	89-92
21738623-2	2011	We have identified a rare flavone, fisetin, which increases the level and activity of glyoxalase 1, the enzyme required for the removal of MG, as well as the synthesis of its essential co-factor, glutathione.	flavone	26-33	glyoxalase 1	Mus musculus	86-98
21034748-2	2010	The objective of our present study was to investigate the effects of the flavone compound, apigenin, on eNOS activity and elucidate the molecular mechanisms underlying these effects in endothelial cells (ECs).	flavone	73-80	nitric oxide synthase 3	Bos taurus	104-108
21108268-6	2010	The flavone compounds without a 6-methoxy group preferentially inhibited JNK3.	flavone	4-11	mitogen-activated protein kinase 10	Homo sapiens	73-77
20698539-4	2010	In the present study, we found that treatment of hispidulin, a flavone isolated from Saussurea involucrate Kar.	flavone	63-70	KAR	Homo sapiens	107-110
20843940-1	2010	beta-Naphthoflavone (BNF) is a synthetic flavone that selectively and potently induces CYP1A enzymes via aryl hydrocarbon receptor activation.	flavone	12-19	aryl hydrocarbon receptor	Rattus norvegicus	105-130
20691240-4	2010	This study examined the potential suppressive effect of the flavone on phorbol ester-induced COX-2 expression in the breast cell lines MCF-10A and MCF-7.	flavone	60-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
20877134-1	2010	The aim of this study was to examine in vitro, by means of kinetic analysis and molecular docking simulations, the effects of the flavone diosmetin and its flavanone analog hesperetin on CYP (cytochrome P450) 2C9-mediated drug metabolism.	flavone	130-137	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	192-212
20670441-1	2010	BACKGROUND: Wheat (Triticum aestivum L.) O-methyltransferase (TaOMT2) catalyzes the sequential methylation of the flavone, tricetin, to its 3"-methyl- (selgin), 3",5"-dimethyl- (tricin) and 3",4",5"-trimethyl ether derivatives.	flavone	114-121	omet	Triticum aestivum	41-60
20670441-1	2010	BACKGROUND: Wheat (Triticum aestivum L.) O-methyltransferase (TaOMT2) catalyzes the sequential methylation of the flavone, tricetin, to its 3"-methyl- (selgin), 3",5"-dimethyl- (tricin) and 3",4",5"-trimethyl ether derivatives.	flavone	114-121	tricetin 3',4',5'-O-trimethyltransferase	Triticum aestivum	62-68
20670441-12	2010	The single amino acid residue in TaOMT2, Val309, determines its preference for tricetin as the substrate, and may define the evolutionary differences between the two closely related proteins, COMT and flavone OMT.	flavone	201-208	tricetin 3',4',5'-O-trimethyltransferase	Triticum aestivum	33-39
20153296-6	2010	Interestingly, only a group of VEGF inhibitors, including apigenin, flavone and 4",7-dihydroxiflavone, reduced the expression of HIF-1alpha under these conditions, whereas others, such as fisetin, luteolin, galangin or quercetin, induced HIF-1alpha expression while reducing those of VEGF.	flavone	68-75	vascular endothelial growth factor A	Homo sapiens	31-35
20153296-6	2010	Interestingly, only a group of VEGF inhibitors, including apigenin, flavone and 4",7-dihydroxiflavone, reduced the expression of HIF-1alpha under these conditions, whereas others, such as fisetin, luteolin, galangin or quercetin, induced HIF-1alpha expression while reducing those of VEGF.	flavone	68-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	129-139
20930378-2	2010	Some flavonoids (apigenin, chrysin, flavone, flavanone, galangin, luteolin, and naringenin) by themselves induced CYP1A1 mRNA expression, especially flavone which was even more effective than beta-NF.	flavone	36-43	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	114-120
20930378-2	2010	Some flavonoids (apigenin, chrysin, flavone, flavanone, galangin, luteolin, and naringenin) by themselves induced CYP1A1 mRNA expression, especially flavone which was even more effective than beta-NF.	flavone	149-156	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	114-120
20462523-7	2010	Signal transduction studies showed that the flavone significantly inhibited extracellular signal-regulated kinase (ERK), p38, and c-jun NH2-terminal kinase (JNK) phosphorylation protein expression.	flavone	44-51	mitogen-activated protein kinase 1	Mus musculus	76-113
20462523-7	2010	Signal transduction studies showed that the flavone significantly inhibited extracellular signal-regulated kinase (ERK), p38, and c-jun NH2-terminal kinase (JNK) phosphorylation protein expression.	flavone	44-51	mitogen-activated protein kinase 1	Mus musculus	115-118
20462523-7	2010	Signal transduction studies showed that the flavone significantly inhibited extracellular signal-regulated kinase (ERK), p38, and c-jun NH2-terminal kinase (JNK) phosphorylation protein expression.	flavone	44-51	mitogen-activated protein kinase 14	Mus musculus	121-124
20462523-7	2010	Signal transduction studies showed that the flavone significantly inhibited extracellular signal-regulated kinase (ERK), p38, and c-jun NH2-terminal kinase (JNK) phosphorylation protein expression.	flavone	44-51	mitogen-activated protein kinase 8	Mus musculus	130-155
20462523-7	2010	Signal transduction studies showed that the flavone significantly inhibited extracellular signal-regulated kinase (ERK), p38, and c-jun NH2-terminal kinase (JNK) phosphorylation protein expression.	flavone	44-51	mitogen-activated protein kinase 8	Mus musculus	157-160
20462523-8	2010	The flavone also inhibited p65-NF-kappaB translocation into the nucleus by I kappaB alpha degradation.	flavone	4-11	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	27-40
20462523-8	2010	The flavone also inhibited p65-NF-kappaB translocation into the nucleus by I kappaB alpha degradation.	flavone	4-11	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	75-89
20436506-2	2010	This study aimed to use a computerized docking approach to examine the interactions between the human AR and phyto-oestrogens (genistein, daidzein, and flavone) and xeno-oestrogens (bisphenol A, 4-nonylphenol, dichlorodiphenyl trichloroethane [DDT], diethylstilbestrol [DES]).	flavone	152-159	androgen receptor	Homo sapiens	102-104
20873564-8	2010	Structure activity study indicated that C4 and C7 hydroxyls on the flavone skeleton were key functional groups to influencing PRL-3 inhibotory activity.	flavone	67-74	protein tyrosine phosphatase 4A3	Homo sapiens	126-131
20214890-6	2010	We performed a high-throughput screen using this system, and identified flavone as a compound that restores the growth of yeast cells overexpressing tankyrase 1.	flavone	72-79	tankyrase	Homo sapiens	149-160
20214890-7	2010	Indeed, flavone inhibited poly(ADP-ribosyl)ation of proteins caused by overexpression of tankyrase 1 in yeast cells.	flavone	8-15	tankyrase	Homo sapiens	89-100
20202836-2	2010	Additionally, the anthocyanidin, delphinidin, and the flavone, tricetinidin, possessing a pyrogallol function were also revealed to suppress expression of Fc epsilonRI.	flavone	54-61	Fc epsilon receptor Ia	Homo sapiens	155-167
19914244-3	2010	Flavone apigenin and flavonol kaempferol directly suppressed the interaction between ERRgamma and PGC-1alpha functioning as inverse agonists.	flavone	0-7	estrogen related receptor gamma	Homo sapiens	85-93
19914244-3	2010	Flavone apigenin and flavonol kaempferol directly suppressed the interaction between ERRgamma and PGC-1alpha functioning as inverse agonists.	flavone	0-7	PPARG coactivator 1 alpha	Homo sapiens	98-108
19914244-4	2010	In contrast, flavone luteolin suppressed PGC-1alpha activity in part through promoting the degradation of PGC-1alpha leading to suppressed ERRgamma activity.	flavone	13-20	PPARG coactivator 1 alpha	Homo sapiens	41-51
19914244-4	2010	In contrast, flavone luteolin suppressed PGC-1alpha activity in part through promoting the degradation of PGC-1alpha leading to suppressed ERRgamma activity.	flavone	13-20	PPARG coactivator 1 alpha	Homo sapiens	106-116
19914244-4	2010	In contrast, flavone luteolin suppressed PGC-1alpha activity in part through promoting the degradation of PGC-1alpha leading to suppressed ERRgamma activity.	flavone	13-20	estrogen related receptor gamma	Homo sapiens	139-147
19839014-0	2009	Utilization of dual retention mechanism on columns with bonded PEG and diol stationary phases for adjusting the separation selectivity of phenolic and flavone natural antioxidants.	flavone	151-158	progestagen associated endometrial protein	Homo sapiens	63-66
22553529-7	2010	In vitro results showed flavone reversed the various oxidants-induced injuries in RPE cells.	flavone	24-31	ribulose-5-phosphate-3-epimerase	Rattus norvegicus	82-85
22553529-8	2010	CONCLUSION: Flavone could prevent the RPE from oxidation-induced injury both in vivo and in vitro.	flavone	12-19	ribulose-5-phosphate-3-epimerase	Rattus norvegicus	38-41
19881301-0	2009	Suppressive effects of T-412, a flavone on interleukin-4 production in T cells.	flavone	32-39	interleukin 4	Mus musculus	43-56
19723047-5	2009	This flavone impaired the function of P-glycoprotein and then increased cellular content of etoposide in the cells.	flavone	5-12	ATP binding cassette subfamily B member 1	Homo sapiens	38-52
19723047-6	2009	Thus, this flavone is likely to act as an inhibitor of P-glycoprotein and potentiate the apoptotic action of etoposide.	flavone	11-18	ATP binding cassette subfamily B member 1	Homo sapiens	55-69
19723047-9	2009	Therefore, this flavone may be used to reduce the excretion of the anticancer agents via P-glycoprotein and increase the pharmacological action of it in cancer cells.	flavone	16-23	ATP binding cassette subfamily B member 1	Homo sapiens	89-103
19885038-0	2009	Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway.	flavone	0-7	ras homolog family member A	Rattus norvegicus	55-59
19264543-0	2009	Spin-forbidden transitions in flavone.	flavone	30-37	spindlin 1	Homo sapiens	0-4
19264543-1	2009	The ground and low-lying excited electronic states of flavone were investigated by means of quantum chemical methods including spin-orbit coupling.	flavone	54-61	spindlin 1	Homo sapiens	127-131
19885038-1	2009	Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1).	flavone	37-44	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	157-162
19885038-2	2009	In the present study, we hypothesized that flavone attenuates vascular contractions through the inhibition of the RhoA/Rho kinase pathway.	flavone	43-50	ras homolog family member A	Rattus norvegicus	114-118
19885038-5	2009	Flavone inhibited, not only vascular contractions induced by these contractors, but also the levels of MLC(20) phosphorylation.	flavone	0-7	myosin light chain 12B	Rattus norvegicus	103-110
19885038-6	2009	Furthermore, flavone inhibited the activation of RhoA which had been induced by either U46619 or NaF.	flavone	13-20	ras homolog family member A	Rattus norvegicus	49-53
19885038-7	2009	Incubation with flavone attenuated U46619-or NaF-induced phosphorylation of MYPT1(Thr855) and CPI17(Thr38), the downstream effectors of Rho-kinase.	flavone	16-23	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	76-81
19885038-7	2009	Incubation with flavone attenuated U46619-or NaF-induced phosphorylation of MYPT1(Thr855) and CPI17(Thr38), the downstream effectors of Rho-kinase.	flavone	16-23	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	94-99
19885038-8	2009	In regards to the Ca(2+)-free solution, flavone inhibited the phosphorylation of MYPT1(Thr855) and CPI17(Thr38), as well as vascular contractions induced by U46619.	flavone	40-47	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	81-86
19885038-8	2009	In regards to the Ca(2+)-free solution, flavone inhibited the phosphorylation of MYPT1(Thr855) and CPI17(Thr38), as well as vascular contractions induced by U46619.	flavone	40-47	protein phosphatase 1, regulatory (inhibitor) subunit 14A	Rattus norvegicus	99-104
19885038-9	2009	These results indicate that flavone attenuates vascular contractions, at least in part, through the inhibition of the RhoA/Rho-kinase pathway.	flavone	28-35	ras homolog family member A	Rattus norvegicus	118-122
19211254-2	2009	The fact that the putative TaCOMT1 exhibits a significantly high sequence homology to another recently characterized wheat flavone-specific OMT (TaOMT2), and that molecular modeling studies indicated several conserved amino acid residues involved in substrate binding and catalysis of both proteins, prompted an investigation of its appropriate substrate specificity.	flavone	123-130	flavone O-methyltransferase 1	Triticum aestivum	27-34
19424633-5	2009	We suggest that diosmetin exerts cytostatic effects in MDA-MB 468 cells, due to CYP1A1 and CYP1B1 catalyzed conversion to the flavone luteolin.	flavone	126-133	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	91-97
19326082-0	2009	Inhibition of overexpressed CDC-25.1 phosphatase activity by flavone in Caenorhabditis elegans.	flavone	61-68	M-phase inducer phosphatase cdc-25.1	Caenorhabditis elegans	28-36
19326082-2	2009	To test this possibility, here we examined whether flavone inhibits the activity of a key cell cycle regulator, CDC-25.1 in C. elegans.	flavone	51-58	M-phase inducer phosphatase cdc-25.1	Caenorhabditis elegans	112-120
19326082-5	2009	The inhibitory effects of flavone on CDC-25.1 were partly, if not completely, due to transcriptional repression.	flavone	26-33	M-phase inducer phosphatase cdc-25.1	Caenorhabditis elegans	37-45
19211254-2	2009	The fact that the putative TaCOMT1 exhibits a significantly high sequence homology to another recently characterized wheat flavone-specific OMT (TaOMT2), and that molecular modeling studies indicated several conserved amino acid residues involved in substrate binding and catalysis of both proteins, prompted an investigation of its appropriate substrate specificity.	flavone	123-130	omet	Triticum aestivum	30-33
19211254-2	2009	The fact that the putative TaCOMT1 exhibits a significantly high sequence homology to another recently characterized wheat flavone-specific OMT (TaOMT2), and that molecular modeling studies indicated several conserved amino acid residues involved in substrate binding and catalysis of both proteins, prompted an investigation of its appropriate substrate specificity.	flavone	123-130	tricetin 3',4',5'-O-trimethyltransferase	Triticum aestivum	145-151
19211254-3	2009	We report here that TaCOMT1 exhibits highest preference for the flavone tricetin, and lowest activity with the lignin precursors, caffeic acid/5-hydroxyferulic acid as the methyl acceptor molecules, indicating that it is not involved in lignin biosynthesis.	flavone	64-71	flavone O-methyltransferase 1	Triticum aestivum	20-27
19211254-4	2009	We recommend its reannotation to a flavone-specific TaOMT1 that is distinct from TaOMT2.	flavone	35-42	flavone O-methyltransferase 1	Triticum aestivum	52-58
18397325-1	2008	Wheat flavone O-methyltransferase catalyzes three sequential methylations of the flavone tricetin.	flavone	6-13	omet	Triticum aestivum	14-33
18570236-5	2008	However, increased expressions of p-IkappaB, NF-kappaB, and p-p38 were found in flavone-treated human PBMCs with significantly suppressed expression of CD25 (IL-2R).	flavone	80-87	interleukin 2 receptor subunit alpha	Homo sapiens	152-156
18570236-5	2008	However, increased expressions of p-IkappaB, NF-kappaB, and p-p38 were found in flavone-treated human PBMCs with significantly suppressed expression of CD25 (IL-2R).	flavone	80-87	interleukin 2 receptor subunit alpha	Homo sapiens	158-163
18987596-6	2008	In response to chemopreventive compounds, the marked induction of CYP1A and CYP2B in liver was observed after diallyl sulphide and flavone treatment.	flavone	131-138	cytochrome P450 family 2 subfamily B member 7, pseudogene	Homo sapiens	76-81
18586291-10	2008	The flavone chrysin, an aromatase inhibitor, and genistein, an isoflavone, each produced a significant (p<0.01) reduction in CCK-induced tension.	flavone	4-11	cholecystokinin	Homo sapiens	128-131
18342637-1	2008	Apigenin, a plant flavone, potentially activates wild-type p53 and induces apoptosis in cancer cells.	flavone	18-25	tumor protein p53	Homo sapiens	59-62
18287248-3	2008	In this report, we examined whether this flavone affects other cellular responses activated by TNF.	flavone	41-48	tumor necrosis factor	Homo sapiens	95-98
18287248-7	2008	It is noteworthy that this flavone also suppressed TNF-induced activation of Akt, a cell survival kinase, and expression of various antiapoptotic proteins, such as IAP-1, IAP-2, XIAP, Bcl-2, Bcl-xL, and TRAF-1.	flavone	27-34	tumor necrosis factor	Homo sapiens	51-54
18287248-7	2008	It is noteworthy that this flavone also suppressed TNF-induced activation of Akt, a cell survival kinase, and expression of various antiapoptotic proteins, such as IAP-1, IAP-2, XIAP, Bcl-2, Bcl-xL, and TRAF-1.	flavone	27-34	AKT serine/threonine kinase 1	Homo sapiens	77-80
18287248-7	2008	It is noteworthy that this flavone also suppressed TNF-induced activation of Akt, a cell survival kinase, and expression of various antiapoptotic proteins, such as IAP-1, IAP-2, XIAP, Bcl-2, Bcl-xL, and TRAF-1.	flavone	27-34	baculoviral IAP repeat containing 3	Homo sapiens	164-169
18287248-7	2008	It is noteworthy that this flavone also suppressed TNF-induced activation of Akt, a cell survival kinase, and expression of various antiapoptotic proteins, such as IAP-1, IAP-2, XIAP, Bcl-2, Bcl-xL, and TRAF-1.	flavone	27-34	baculoviral IAP repeat containing 2	Homo sapiens	171-176
18287248-7	2008	It is noteworthy that this flavone also suppressed TNF-induced activation of Akt, a cell survival kinase, and expression of various antiapoptotic proteins, such as IAP-1, IAP-2, XIAP, Bcl-2, Bcl-xL, and TRAF-1.	flavone	27-34	X-linked inhibitor of apoptosis	Homo sapiens	178-182
18287248-7	2008	It is noteworthy that this flavone also suppressed TNF-induced activation of Akt, a cell survival kinase, and expression of various antiapoptotic proteins, such as IAP-1, IAP-2, XIAP, Bcl-2, Bcl-xL, and TRAF-1.	flavone	27-34	BCL2 apoptosis regulator	Homo sapiens	184-189
18287248-7	2008	It is noteworthy that this flavone also suppressed TNF-induced activation of Akt, a cell survival kinase, and expression of various antiapoptotic proteins, such as IAP-1, IAP-2, XIAP, Bcl-2, Bcl-xL, and TRAF-1.	flavone	27-34	BCL2 like 1	Homo sapiens	191-197
18287248-7	2008	It is noteworthy that this flavone also suppressed TNF-induced activation of Akt, a cell survival kinase, and expression of various antiapoptotic proteins, such as IAP-1, IAP-2, XIAP, Bcl-2, Bcl-xL, and TRAF-1.	flavone	27-34	TNF receptor associated factor 1	Homo sapiens	203-209
17647269-2	2008	In this study, we therefore investigated the effects of ginkgolides, the main constituent of the non-flavone fraction of EGb 761, on the content and activity of HIF-1alpha, a key factor to determine HIF-1 activity, in hypoxic PC12 cells induced by cobalt chloride.	flavone	101-108	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	161-171
18294953-0	2008	Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor.	flavone	92-99	aryl-hydrocarbon receptor	Mus musculus	112-137
18328452-5	2008	This flavone seems to interfere with the expression of the inducible nitric oxide synthase (iNOS) immediately after LPS-IFNgamma-macrophage stimulation.	flavone	5-12	nitric oxide synthase 2, inducible	Mus musculus	59-90
18328452-5	2008	This flavone seems to interfere with the expression of the inducible nitric oxide synthase (iNOS) immediately after LPS-IFNgamma-macrophage stimulation.	flavone	5-12	nitric oxide synthase 2, inducible	Mus musculus	92-96
18504236-3	2008	The results demonstrate that Augmentation Index measured with arteriography and C reactive protein (CRP) levels were significantly ameliorated after 2 x 2 months Flavon Max therapy.	flavone	162-168	C-reactive protein	Homo sapiens	80-98
18506592-0	2008	Pharmacophore mapping of flavone derivatives for aromatase inhibition.	flavone	25-32	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	49-58
18454852-6	2008	The cytotoxicity of the flavone, its effect on the cell cycle of the abovementioned cell lines, and its metabolism by CYP1 family enzymes were examined.	flavone	24-31	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	118-122
18454852-9	2008	Moreover, CYP1 family enzymes were shown to metabolise eupatorin in vitro to the flavone cirsiliol and two other unidentified metabolites.	flavone	81-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	10-14
18454852-13	2008	CONCLUSION: The flavone eupatorin is selectively activated in breast cancer cells, but not in normal breast cells, due to CYP1 family metabolism.	flavone	16-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	122-126
19088450-1	2008	The flavone apigenin has been previously selected as a potent pharmacological activator of the CFTR Cl(-) channel, however, its utility for the activation of CFTR in vivo is expected to be limited because flavonoids are readily metabolized.	flavone	4-11	CF transmembrane conductance regulator	Homo sapiens	95-99
19325719-5	2008	Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.	flavone	28-35	TNF superfamily member 10	Homo sapiens	79-84
18504236-3	2008	The results demonstrate that Augmentation Index measured with arteriography and C reactive protein (CRP) levels were significantly ameliorated after 2 x 2 months Flavon Max therapy.	flavone	162-168	C-reactive protein	Homo sapiens	100-103
17643414-0	2007	Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression.	flavone	0-7	poly(ADP-ribose) polymerase 1	Homo sapiens	11-17
17643414-4	2007	In this study, the flavonoid compound flavone was demonstrated to significantly inhibit the enzyme activity of PARP-1.	flavone	38-45	poly(ADP-ribose) polymerase 1	Homo sapiens	111-117
17643414-6	2007	In addition, flavone was found to reduce the lipopolysaccharide (LPS)-induced interleukin (IL)-8 production in pulmonary epithelial cells, which was confirmed by transcription analysis.	flavone	13-20	C-X-C motif chemokine ligand 8	Homo sapiens	78-96
17560542-4	2007	Flavone, flavonol, and flavanone but not catechin inhibited the specific binding between the AhR and 3-methylcholanthrene dose-dependently, indicating that the former three subclasses possibly act as competitive antagonists of the AhR.	flavone	0-7	aryl hydrocarbon receptor	Homo sapiens	93-96
17880363-5	2007	We hypothesized that treatment with flavone inhibits vascular smooth muscle contraction by decreasing the phosphorylation of the myosin phosphatase target subunit (MYPT1).	flavone	36-43	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	164-169
17880363-9	2007	Flavone dose-dependently inhibited the U46619-induced contractile response and myosin light chain (MLC(20)) phosphorylation.	flavone	0-7	myosin light chain 12B	Rattus norvegicus	99-106
17880363-11	2007	Incubation with flavone (100 or 300 micromol/L) for 30 min attenuated the phosphorylation of MYPT1(Thr855), but not MYPT1(Thr697).	flavone	16-23	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	93-98
17880363-13	2007	It is concluded that treatment with flavone inhibits vascular smooth muscle contraction by decreasing the phosphorylation of the MYPT1.	flavone	36-43	protein phosphatase 1, regulatory subunit 12A	Rattus norvegicus	129-134
17560542-4	2007	Flavone, flavonol, and flavanone but not catechin inhibited the specific binding between the AhR and 3-methylcholanthrene dose-dependently, indicating that the former three subclasses possibly act as competitive antagonists of the AhR.	flavone	0-7	aryl hydrocarbon receptor	Homo sapiens	231-234
17560542-7	2007	These results suggest that flavone, flavonol, and flavanone act as competitive antagonists of the AhR, while catechin associates with the AhRc and indirectly exhibits its antagonistic effects.	flavone	27-34	aryl hydrocarbon receptor	Homo sapiens	98-101
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	flavone	41-48	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	125-131
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	flavone	41-48	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	163-169
17599282-4	2007	In the present study, the effects of the flavone chrysin and six natural coumarins isolated from various Rutaceous plants on UGT1A6-dependent P-nitrophenol and/or UGT1A1-dependent bilirubin glucuronoconjugation activities were evaluated in cultured rat and human hepatocytes and compared to those of the prototypical UGT1A inducers beta-naphthoflavone, phenobarbital and clofibric acid.	flavone	41-48	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	125-130
17944194-0	2007	[Effects of flavone from leaves of Diospyros kaki on expression of apoptosis signal-regulating kinase 1 and rat vascular smooth muscle cells proliferation by tumor necrosis factor alpha in vitro].	flavone	12-19	tumor necrosis factor	Rattus norvegicus	158-185
17944194-1	2007	OBJECTIVE: To observe the effects of flavone from leaves of Diospyros kaki on expression of apoptosis signal-regulating kinase 1 (ASK1) and rat vascular smooth muscle cells (VSMCs) proliferation by tumor necrosis factor alpha in vitro.	flavone	37-44	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	130-134
17944194-1	2007	OBJECTIVE: To observe the effects of flavone from leaves of Diospyros kaki on expression of apoptosis signal-regulating kinase 1 (ASK1) and rat vascular smooth muscle cells (VSMCs) proliferation by tumor necrosis factor alpha in vitro.	flavone	37-44	tumor necrosis factor	Rattus norvegicus	198-225
17944194-9	2007	With TNF-alpha stimulation, flavone from leaves of Diospyros kaki significantly inhibited rat expression of ASK1 protein enhanced by TNF-alpha was significantly inhibited rat-VSMNCs proliferation (1.247 +/- 0.061 vs. 1.865 +/- 0.093, p < 0.05).	flavone	28-35	tumor necrosis factor	Rattus norvegicus	5-14
17944194-9	2007	With TNF-alpha stimulation, flavone from leaves of Diospyros kaki significantly inhibited rat expression of ASK1 protein enhanced by TNF-alpha was significantly inhibited rat-VSMNCs proliferation (1.247 +/- 0.061 vs. 1.865 +/- 0.093, p < 0.05).	flavone	28-35	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	108-112
17944194-9	2007	With TNF-alpha stimulation, flavone from leaves of Diospyros kaki significantly inhibited rat expression of ASK1 protein enhanced by TNF-alpha was significantly inhibited rat-VSMNCs proliferation (1.247 +/- 0.061 vs. 1.865 +/- 0.093, p < 0.05).	flavone	28-35	tumor necrosis factor	Rattus norvegicus	133-142
17944194-10	2007	The expression of ASK1 protein enhanced by TNF-alpha was significantly inhibited by flavone from leaves of Diospyros kaki in VSMCs.	flavone	84-91	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	18-22
17944194-10	2007	The expression of ASK1 protein enhanced by TNF-alpha was significantly inhibited by flavone from leaves of Diospyros kaki in VSMCs.	flavone	84-91	tumor necrosis factor	Rattus norvegicus	43-52
17944194-11	2007	CONCLUSION: Flavone from leaves of Diospyros kaki can significantly inhibit expression of ASK1 protein stimulated by TNF-alpha of rat VSMcs in vitro.	flavone	12-19	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	90-94
17944194-11	2007	CONCLUSION: Flavone from leaves of Diospyros kaki can significantly inhibit expression of ASK1 protein stimulated by TNF-alpha of rat VSMcs in vitro.	flavone	12-19	tumor necrosis factor	Rattus norvegicus	117-126
17379515-0	2007	Synthesis, characterization, and estrogen receptor binding affinity of flavone-, indole-, and furan-estradiol conjugates.	flavone	71-78	estrogen receptor 1	Homo sapiens	33-50
17379515-3	2007	In vitro competitive binding assays for the estrogen receptor (alpha-ER), using [(3)H]estradiol (RBA=100) as a competitor, revealed that a two-carbon alkyl linker combined with a flavone conjugate provided the highest binding affinity (RBA approximately 9), warranting further studies on their potential use as selective estrogen-receptor modulators (SERMs) for hormone-replacement therapies.	flavone	179-186	estrogen receptor 1	Homo sapiens	44-61
17637178-0	2007	Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.	flavone	19-26	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	41-60
17268053-4	2007	On the other hand, flavone and flavonols such as rutin (a 3-glycosidic flavone), quercitrin (a 3-glycosidic flavonol), myricetin, and kaempferol (flavonols), respectively, lowered the CL intensity to a greater extent at low concentrations (<0.1 microM) when catalase was present than when catalase was absent, indicating that these flavonoids activate catalase.	flavone	19-26	catalase	Homo sapiens	261-269
17711723-1	2007	OBJECTIVE: To investigate the anti atherosclerosis effect and related mechanisms of total flavone of radix puerariae (TFRP) on atherosclerotic plaques in apoE gene deficiency (apoE-/-) mice.	flavone	90-97	apolipoprotein E	Mus musculus	154-158
17317193-3	2007	The design of target molecules was based on earlier results dealing with ABCG2 inhibition with flavone and chromone derivatives.	flavone	95-102	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-78
17268053-4	2007	On the other hand, flavone and flavonols such as rutin (a 3-glycosidic flavone), quercitrin (a 3-glycosidic flavonol), myricetin, and kaempferol (flavonols), respectively, lowered the CL intensity to a greater extent at low concentrations (<0.1 microM) when catalase was present than when catalase was absent, indicating that these flavonoids activate catalase.	flavone	19-26	catalase	Homo sapiens	292-300
17268053-4	2007	On the other hand, flavone and flavonols such as rutin (a 3-glycosidic flavone), quercitrin (a 3-glycosidic flavonol), myricetin, and kaempferol (flavonols), respectively, lowered the CL intensity to a greater extent at low concentrations (<0.1 microM) when catalase was present than when catalase was absent, indicating that these flavonoids activate catalase.	flavone	19-26	catalase	Homo sapiens	292-300
17418982-1	2007	BACKGROUND: Dietary flavone was previously shown to increase the expression of deleted in liver cancer-1 gene (DLC-1) in HT-29 colon carcinoma cell line [Herzog A, Kindermann B, Doring F, Daniel H, Wenzel U. Pleiotropic molecular effects of the pro-apoptotic dietary constituent flavone in human colon cancer cells identified by protein and mRNA expression profiling.	flavone	20-27	DLC1 Rho GTPase activating protein	Homo sapiens	111-116
17418982-1	2007	BACKGROUND: Dietary flavone was previously shown to increase the expression of deleted in liver cancer-1 gene (DLC-1) in HT-29 colon carcinoma cell line [Herzog A, Kindermann B, Doring F, Daniel H, Wenzel U. Pleiotropic molecular effects of the pro-apoptotic dietary constituent flavone in human colon cancer cells identified by protein and mRNA expression profiling.	flavone	279-286	DLC1 Rho GTPase activating protein	Homo sapiens	111-116
17418982-5	2007	METHODS: Here, the effect of flavone was examined in several DLC-1-deficient cell lines derived from different types human cancer using assays for cell proliferation, gene expression and transfer.	flavone	29-36	DLC1 Rho GTPase activating protein	Homo sapiens	61-66
17418982-6	2007	RESULTS: We show that exposure to 150 microM flavone increased DLC1 expression in breast but not in liver or prostate carcinoma cells or a nonmalignant breast epithelial cell line.	flavone	45-52	DLC1 Rho GTPase activating protein	Homo sapiens	63-67
17418982-7	2007	Flavone restored the expression of DLC1 in the breast carcinoma cell lines MDA-MB-468, MDA-MB-361, and BT20 as well as in the colon carcinoma cell line HT-29 all of which are DLC-1-negative due to promoter hypermethylation.	flavone	0-7	DLC1 Rho GTPase activating protein	Homo sapiens	35-39
17418982-7	2007	Flavone restored the expression of DLC1 in the breast carcinoma cell lines MDA-MB-468, MDA-MB-361, and BT20 as well as in the colon carcinoma cell line HT-29 all of which are DLC-1-negative due to promoter hypermethylation.	flavone	0-7	DLC1 Rho GTPase activating protein	Homo sapiens	175-180
17418982-8	2007	We further show that flavone inhibited cell proliferation, induced cell cycle arrest at G(2)-M, increased p21(Waf1) gene expression, and caused apoptosis.	flavone	21-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	106-109
17418982-8	2007	We further show that flavone inhibited cell proliferation, induced cell cycle arrest at G(2)-M, increased p21(Waf1) gene expression, and caused apoptosis.	flavone	21-28	cyclin dependent kinase inhibitor 1A	Homo sapiens	110-114
17418982-9	2007	Microarray analysis of these aggressive and metastatic breast carcinoma cells revealed 29 flavone-responsive genes, among which the DNA damage-inducible GADD genes were up-regulated and the proto-oncogene STMN1 and IGFBP3 were down-regulated.	flavone	90-97	stathmin 1	Homo sapiens	205-210
17418982-9	2007	Microarray analysis of these aggressive and metastatic breast carcinoma cells revealed 29 flavone-responsive genes, among which the DNA damage-inducible GADD genes were up-regulated and the proto-oncogene STMN1 and IGFBP3 were down-regulated.	flavone	90-97	insulin like growth factor binding protein 3	Homo sapiens	215-221
17159770-5	2006	RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver.	flavone	147-154	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	56-62
17604209-0	2007	Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities.	flavone	34-41	histone deacetylase 9	Homo sapiens	79-83
17604209-6	2007	Flavone induces apoptosis which is accompanied by caspase activation and p16, p21 and TRAIL over-expression in human myeloid leukemia cells.	flavone	0-7	cyclin dependent kinase inhibitor 2A	Homo sapiens	73-76
17604209-6	2007	Flavone induces apoptosis which is accompanied by caspase activation and p16, p21 and TRAIL over-expression in human myeloid leukemia cells.	flavone	0-7	H3 histone pseudogene 16	Homo sapiens	78-81
17604209-6	2007	Flavone induces apoptosis which is accompanied by caspase activation and p16, p21 and TRAIL over-expression in human myeloid leukemia cells.	flavone	0-7	TNF superfamily member 10	Homo sapiens	86-91
17604209-8	2007	In both cell lines and myeloid leukemia patients blasts the apoptotic activity of Feijoa extract and Flavone is accompanied by increase of histone and non-histone acetylation levels and by HDAC inhibition.	flavone	101-108	histone deacetylase 9	Homo sapiens	189-193
17604209-9	2007	Our findings show for the first time that the Feijoa apoptotic active principle is the Flavone and that this activity correlates with the induction of HDAC inhibition, supporting the hypothesis of its epigenetic pro-apoptotic regulation in cancer systems.	flavone	87-94	histone deacetylase 9	Homo sapiens	151-155
17982879-3	2007	Here we demonstrate that the flavone luteolin confers neuroprotection against oxidative stress via activation of the nuclear factor erythroid-2-related factor 2 (Nrf2), a transcription factor central to the maintenance of the cellular redox homeostasis.	flavone	29-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	117-160
17982879-3	2007	Here we demonstrate that the flavone luteolin confers neuroprotection against oxidative stress via activation of the nuclear factor erythroid-2-related factor 2 (Nrf2), a transcription factor central to the maintenance of the cellular redox homeostasis.	flavone	29-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	162-166
17227625-0	2007	Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2.	flavone	22-29	ATP binding cassette subfamily C member 2	Homo sapiens	89-130
17031860-1	2007	The purpose of this study was to examine the effects of extracts and flavone derivatives from the rhizome of Kaempferia parviflora on P-glycoprotein (P-gp)-mediated transport in LLC-GA5-COL150, a transfectant cell line of a porcine kidney epithelial cell line LLC-PK1 with human MDR1 cDNA.	flavone	69-76	ATP binding cassette subfamily B member 1	Homo sapiens	279-283
17090139-5	2006	The expression level of the CYP1A1 mRNA and protein induced by TCDD was suppressed by flavone, galangin, and tangeretin.	flavone	86-93	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	28-34
16428296-1	2005	Many flavone derivatives inhibit FAS, and their A and B rings play an important role, but is the C ring necessary for the inhibition of FAS?	flavone	5-12	fatty acid synthase	Homo sapiens	33-36
29435895-3	2006	The principal and the most pronounced features of these phenolic constituents are the assembly of an isoprenyl substituent at C-3 of a flavone skeleton by closure of an ether bridge or a carbon-carbon linkage with the B ring of the skeleton, which may further rearrange into xanthone to produce various classes of natural products.	flavone	135-142	complement component 3	Mus musculus	126-129
16848753-0	2006	Molecular interactions between human cytochrome P450 1A2 and flavone derivatives.	flavone	61-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	37-56
16504502-1	2006	A series of C-C biflavones was designed to investigate the relationship between structural array of different flavone-flavone subunit linkage and the inhibitory activity against phospholipase A2 (PLA2).	flavone	18-25	phospholipase A2 group IB	Homo sapiens	178-194
16504502-1	2006	A series of C-C biflavones was designed to investigate the relationship between structural array of different flavone-flavone subunit linkage and the inhibitory activity against phospholipase A2 (PLA2).	flavone	18-25	phospholipase A2 group IB	Homo sapiens	196-200
16504502-1	2006	A series of C-C biflavones was designed to investigate the relationship between structural array of different flavone-flavone subunit linkage and the inhibitory activity against phospholipase A2 (PLA2).	flavone	110-117	phospholipase A2 group IB	Homo sapiens	178-194
16504502-1	2006	A series of C-C biflavones was designed to investigate the relationship between structural array of different flavone-flavone subunit linkage and the inhibitory activity against phospholipase A2 (PLA2).	flavone	110-117	phospholipase A2 group IB	Homo sapiens	196-200
16443668-3	2006	We previously demonstrated that PD98059 (2"-amino-3"-methoxyflavone), a flavone derivative and selective mitogen-activated protein kinase kinase (MEK) 1 inhibitor, enhanced the insulin-mediated increase in GSH levels.	flavone	60-67	mitogen activated protein kinase kinase 1	Rattus norvegicus	105-152
16263302-0	2006	Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1).	flavone	51-58	ATP binding cassette subfamily C member 1	Homo sapiens	113-154
16263302-0	2006	Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1).	flavone	51-58	ATP binding cassette subfamily C member 1	Homo sapiens	156-161
16263302-0	2006	Synthesis and biological evaluation of a series of flavone derivatives as potential radioligands for imaging the multidrug resistance-associated protein 1 (ABCC1/MRP1).	flavone	51-58	ATP binding cassette subfamily C member 1	Homo sapiens	162-166
16263302-3	2006	Six flavone-based compounds were synthesized and evaluated for their cytotoxic activity and MDR-reversing capacity using hMRP1 or hMDR1 overexpressing cell lines for in vitro assays.	flavone	4-11	ATP binding cassette subfamily C member 1	Homo sapiens	121-126
16263302-3	2006	Six flavone-based compounds were synthesized and evaluated for their cytotoxic activity and MDR-reversing capacity using hMRP1 or hMDR1 overexpressing cell lines for in vitro assays.	flavone	4-11	ATP binding cassette subfamily B member 1	Homo sapiens	130-135
16263302-4	2006	All the flavone derivatives were highly selective for hMRP1-expressing cell lines.	flavone	8-15	ATP binding cassette subfamily C member 1	Homo sapiens	54-59
16730127-6	2006	Enzyme assays and kinetic analyses indicate that TaOMT2 exhibits a pronounced preference for the flavone, tricetin and gives rise to three methylated enzyme reaction products that were identified by TLC, HPLC and ESI-MS/MS as its mono-, di- and trimethyl ether derivatives.	flavone	97-104	tricetin 3',4',5'-O-trimethyltransferase	Triticum aestivum	49-55
16332809-5	2005	Improvement of flavone biosynthesis was achieved by overexpressing the yeast P450 reductase CPR1 in the FSII-expressing recombinant strain and by using acetate rather than glucose or raffinose as the carbon source.	flavone	15-22	peptidylprolyl isomerase CPR1	Saccharomyces cerevisiae S288C	92-96
16428296-1	2005	Many flavone derivatives inhibit FAS, and their A and B rings play an important role, but is the C ring necessary for the inhibition of FAS?	flavone	5-12	fatty acid synthase	Homo sapiens	136-139
15890477-5	2005	The effect observed here after pretreatment with oltipraz, flavone and I3C was the result of the induction of both CYP1A1 and CYP1B1, as was confirmed by analysis of CYP1A1 (protein and mRNA) and CYP1B1 (mRNA) expression.	flavone	59-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	115-121
16568663-0	2005	[Effect of Herba Epimedii Flavone on expression of OPG and RANKL in rat osteoblasts].	flavone	26-33	TNF receptor superfamily member 11B	Rattus norvegicus	51-54
16568663-0	2005	[Effect of Herba Epimedii Flavone on expression of OPG and RANKL in rat osteoblasts].	flavone	26-33	TNF superfamily member 11	Rattus norvegicus	59-64
16279784-4	2005	The binding affinities of flavone derivatives for A beta aggregates varied from 13 to 77 nM.	flavone	26-33	amyloid beta (A4) precursor protein	Mus musculus	50-56
15890477-5	2005	The effect observed here after pretreatment with oltipraz, flavone and I3C was the result of the induction of both CYP1A1 and CYP1B1, as was confirmed by analysis of CYP1A1 (protein and mRNA) and CYP1B1 (mRNA) expression.	flavone	59-66	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	126-132
15890477-5	2005	The effect observed here after pretreatment with oltipraz, flavone and I3C was the result of the induction of both CYP1A1 and CYP1B1, as was confirmed by analysis of CYP1A1 (protein and mRNA) and CYP1B1 (mRNA) expression.	flavone	59-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	166-172
15890477-5	2005	The effect observed here after pretreatment with oltipraz, flavone and I3C was the result of the induction of both CYP1A1 and CYP1B1, as was confirmed by analysis of CYP1A1 (protein and mRNA) and CYP1B1 (mRNA) expression.	flavone	59-66	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	196-202
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	flavone	185-192	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	55-61
15890477-6	2005	In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells.	flavone	185-192	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	66-72
15689157-8	2005	However, CDK2 and HCK kinase in complex with other flavone inhibitors such as quercetin and flavopiridol showed a different binding mode with the inhibitor rotated by about 180 degrees.	flavone	51-58	cyclin dependent kinase 2	Homo sapiens	9-13
15914008-0	2005	Theoretical quantitative structure-activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes.	flavone	61-68	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	94-121
15909122-4	2005	Flavone induces the activation of caspases 2, 3, 8, 9 and 10 and a decrease of mitochondrial anti-apoptotic Bcl(2) protein expression.	flavone	0-7	caspase 1	Homo sapiens	34-42
15909122-4	2005	Flavone induces the activation of caspases 2, 3, 8, 9 and 10 and a decrease of mitochondrial anti-apoptotic Bcl(2) protein expression.	flavone	0-7	BCL2 apoptosis regulator	Homo sapiens	108-113
15689157-8	2005	However, CDK2 and HCK kinase in complex with other flavone inhibitors such as quercetin and flavopiridol showed a different binding mode with the inhibitor rotated by about 180 degrees.	flavone	51-58	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	18-21
15689157-9	2005	The structural information of the CDK6-fisetin complex is correlated with the binding affinities of different flavone inhibitors for CDK6.	flavone	110-117	cyclin dependent kinase 6	Homo sapiens	34-38
15689157-9	2005	The structural information of the CDK6-fisetin complex is correlated with the binding affinities of different flavone inhibitors for CDK6.	flavone	110-117	cyclin dependent kinase 6	Homo sapiens	133-137
15589400-0	2005	Suppression of cyclooxygenase-2 expression of skin fibroblasts by wogonin, a plant flavone from Scutellaria radix.	flavone	83-90	prostaglandin-endoperoxide synthase 2	Mus musculus	15-31
15292045-4	2004	Treatment with the flavone apigenin, which activates the Na(+)-K(+)-2Cl(-) cotransporter and increases cytosolic Cl(-) concentration, markedly suppressed the hypotonicity-induced increase in alpha-ENaC mRNA expression.	flavone	19-26	sodium channel epithelial 1 subunit alpha	Homo sapiens	191-201
15499387-4	2004	We observed the down-regulation of the hyperphosphorylated form of retinoblastoma gene product and cyclin-dependent kinases 2 and 4 in flavone-treated cells, but it had no affect on the expression of p53 and cyclin-dependent kinase inhibitors p21(CIP/Waf1) and p27(Kip).	flavone	135-142	cyclin dependent kinase inhibitor 1A	Homo sapiens	243-246
15539763-4	2004	Recent studies have also shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase, and several pivotal cytokines.	flavone	67-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	203-219
15315784-8	2004	The mGSTM2 was detected only in flavone-fed animals, indicating an up-regulation of this isozyme by flavone.	flavone	32-39	glutathione S-transferase, mu 2	Mus musculus	4-10
15315784-8	2004	The mGSTM2 was detected only in flavone-fed animals, indicating an up-regulation of this isozyme by flavone.	flavone	100-107	glutathione S-transferase, mu 2	Mus musculus	4-10
15315784-4	2004	In this study we describe the sub-chronic effect of feeding flavone (2500 mg/kg diet) on the expression of mGSTA3, mGSTP1, mGSTM1, and mGSTM2 in male and female mice.	flavone	60-67	glutathione S-transferase, alpha 3	Mus musculus	107-113
15315784-4	2004	In this study we describe the sub-chronic effect of feeding flavone (2500 mg/kg diet) on the expression of mGSTA3, mGSTP1, mGSTM1, and mGSTM2 in male and female mice.	flavone	60-67	glutathione S-transferase, pi 1	Mus musculus	115-121
15315784-4	2004	In this study we describe the sub-chronic effect of feeding flavone (2500 mg/kg diet) on the expression of mGSTA3, mGSTP1, mGSTM1, and mGSTM2 in male and female mice.	flavone	60-67	glutathione S-transferase, mu 1	Mus musculus	123-129
15315784-4	2004	In this study we describe the sub-chronic effect of feeding flavone (2500 mg/kg diet) on the expression of mGSTA3, mGSTP1, mGSTM1, and mGSTM2 in male and female mice.	flavone	60-67	glutathione S-transferase, mu 2	Mus musculus	135-141
15315784-6	2004	Flavone induced mGSTM1 and mGSTP1 in a gender and isozyme specific manner yet had no appreciable effect on the expression of mGSTA3.	flavone	0-7	glutathione S-transferase, mu 1	Mus musculus	16-22
15315784-6	2004	Flavone induced mGSTM1 and mGSTP1 in a gender and isozyme specific manner yet had no appreciable effect on the expression of mGSTA3.	flavone	0-7	glutathione S-transferase, pi 1	Mus musculus	27-33
15499387-4	2004	We observed the down-regulation of the hyperphosphorylated form of retinoblastoma gene product and cyclin-dependent kinases 2 and 4 in flavone-treated cells, but it had no affect on the expression of p53 and cyclin-dependent kinase inhibitors p21(CIP/Waf1) and p27(Kip).	flavone	135-142	cyclin dependent kinase inhibitor 1A	Homo sapiens	251-255
15499387-4	2004	We observed the down-regulation of the hyperphosphorylated form of retinoblastoma gene product and cyclin-dependent kinases 2 and 4 in flavone-treated cells, but it had no affect on the expression of p53 and cyclin-dependent kinase inhibitors p21(CIP/Waf1) and p27(Kip).	flavone	135-142	interferon alpha inducible protein 27	Homo sapiens	261-264
15499387-5	2004	Flavone almost completely inhibited the activation of extracellular signal regulated kinase 1.	flavone	0-7	mitogen-activated protein kinase 3	Homo sapiens	54-93
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	133-140	caspase 3	Homo sapiens	14-23
15473664-1	2004	Recent investigations have shown that certain flavonoids, especially flavone derivatives, inhibit nitric oxide (NO) production by inducible NO synthase (iNOS) in macrophages, which contribute their anti-inflammatory action.	flavone	69-76	nitric oxide synthase 2, inducible	Mus musculus	130-151
15473664-1	2004	Recent investigations have shown that certain flavonoids, especially flavone derivatives, inhibit nitric oxide (NO) production by inducible NO synthase (iNOS) in macrophages, which contribute their anti-inflammatory action.	flavone	69-76	nitric oxide synthase 2, inducible	Mus musculus	153-157
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	133-140	caspase 3	Homo sapiens	89-98
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	133-140	poly(ADP-ribose) polymerase 1	Homo sapiens	110-114
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	133-140	caspase 3	Homo sapiens	89-98
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	133-140	caspase 1	Homo sapiens	233-242
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	279-286	caspase 3	Homo sapiens	14-23
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	279-286	caspase 3	Homo sapiens	89-98
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	279-286	poly(ADP-ribose) polymerase 1	Homo sapiens	110-114
15289867-6	2004	Activation of caspase 3 protein procession and enzyme activity with inducing cleavage of caspase 3 substrates PARP was identified in flavone-treated cells, and an inhibitory peptide Ac-DEVD-FMK for caspase 3, but not Ac-YVAD-FMK for caspase 1, attenuates the cytotoxic effect of flavone in COLO205 and HT29 cells.	flavone	279-286	caspase 3	Homo sapiens	89-98
15289867-7	2004	Elevation of p21 but no p53 protein was observed in flavone-treated cells.	flavone	52-59	H3 histone pseudogene 16	Homo sapiens	13-16
15289867-9	2004	In vivo anti-tumor study indicates that flavone exhibits ability to inhibit tumor formation elicited by s.c. injection of COLO205 cells in nude mice, and apoptotic cells and an increase in p21, but not p53, protein were observed in tumor tissues derived from flavone-treated group.	flavone	40-47	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	189-192
15289867-10	2004	Additionally, flavone induced apoptosis in primary colon carcinoma cells COLO205-X with appearance of DNA ladders, caspase 3 protein procession, PARP protein cleavage, and an increase in p21 (not p53) protein.	flavone	14-21	caspase 3	Homo sapiens	115-124
15289867-10	2004	Additionally, flavone induced apoptosis in primary colon carcinoma cells COLO205-X with appearance of DNA ladders, caspase 3 protein procession, PARP protein cleavage, and an increase in p21 (not p53) protein.	flavone	14-21	poly(ADP-ribose) polymerase 1	Homo sapiens	145-149
15289867-10	2004	Additionally, flavone induced apoptosis in primary colon carcinoma cells COLO205-X with appearance of DNA ladders, caspase 3 protein procession, PARP protein cleavage, and an increase in p21 (not p53) protein.	flavone	14-21	H3 histone pseudogene 16	Homo sapiens	187-190
15289867-10	2004	Additionally, flavone induced apoptosis in primary colon carcinoma cells COLO205-X with appearance of DNA ladders, caspase 3 protein procession, PARP protein cleavage, and an increase in p21 (not p53) protein.	flavone	14-21	tumor protein p53	Homo sapiens	196-199
15289867-11	2004	These data provide evidence to suggest that flavone is an effective agent to induce apoptosis in colorectal carcinoma cells in vitro and in vivo; activation of caspase 3, ROS production, and increasing p21 protein are involved.	flavone	44-51	caspase 3	Homo sapiens	160-169
15289867-11	2004	These data provide evidence to suggest that flavone is an effective agent to induce apoptosis in colorectal carcinoma cells in vitro and in vivo; activation of caspase 3, ROS production, and increasing p21 protein are involved.	flavone	44-51	H3 histone pseudogene 16	Homo sapiens	202-205
15276069-5	2004	Antigen-specific IFN-gamma production was reduced more effectively by flavones than T-cell proliferation, suggesting that the intracellular pathway for IFN-gamma production in T cells is particularly sensitive to flavone inhibition.	flavone	70-77	interferon gamma	Homo sapiens	17-26
15276069-5	2004	Antigen-specific IFN-gamma production was reduced more effectively by flavones than T-cell proliferation, suggesting that the intracellular pathway for IFN-gamma production in T cells is particularly sensitive to flavone inhibition.	flavone	70-77	interferon gamma	Homo sapiens	152-161
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	flavone	88-95	interleukin 1 beta	Mus musculus	157-174
14754875-6	2004	RT-PCR analysis and western blot analysis revealed that ascorbic acid specifically blocked the decrease of bcl-X(L) by camptothecin or flavone.	flavone	135-142	BCL2 like 1	Homo sapiens	107-115
14754875-8	2004	precedes the down-regulation of bcl-X(L) by camptothecin and flavone and ascorbic acid at a concentration of 1 mM prevented the generation of this reactive oxygen species.	flavone	61-68	BCL2 like 1	Homo sapiens	32-40
15203283-3	2004	Moreover, flavopiridol, another flavone already known for its pro-apoptotic properties in B-CLL cells, was also found to down-regulate both iNOS expression and NO production.	flavone	32-39	nitric oxide synthase 2	Homo sapiens	140-144
15267241-4	2004	Previous studies have exploited flavone and flavanone scaffolds for the development of new aromatase inhibitors.	flavone	32-39	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	91-100
15081147-10	2004	Based on these results, It might be considered that the bioavailability of paclitaxel coadministered with flavone was significantly enhanced by the both inhibition of cytochrome P-450 and the P-gp efflux pump in the intestinal mucosa.	flavone	106-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	167-183
15081147-10	2004	Based on these results, It might be considered that the bioavailability of paclitaxel coadministered with flavone was significantly enhanced by the both inhibition of cytochrome P-450 and the P-gp efflux pump in the intestinal mucosa.	flavone	106-113	phosphoglycolate phosphatase	Rattus norvegicus	192-196
15041478-11	2004	To identify the GS-X pump responsible for the DNP-SG efflux in MCF7 cells, the effects of three characteristic flavonoids quercetin, flavone and taxifolin on MRP1 and MRP2 activity were studied using transfected MDCKII cells.	flavone	133-140	ATP binding cassette subfamily C member 1	Homo sapiens	16-20
15036463-3	2004	The present study examined the effect of ethanol extract of propolis (EEP) and selected flavone derivatives (chrysin, galangin, kaempferol and quercetin) on interleukin-1beta (IL-1beta) and inducible nitric oxide synthase (iNOS) gene expression in lipopolysaccharide (LPS)-induced J774A.1 macrophages.	flavone	88-95	interleukin 1 beta	Mus musculus	176-184
15272781-1	2004	OBJECTIVE: To observe the effects of flavone from leaves of Diospyros kaki on adventitial fibroblasts proliferation by advanced oxidation protein products (AOPP) in vitro.	flavone	37-44	peroxiredoxin 5	Mus musculus	156-160
15272781-8	2004	With AOPP stimulation, flavone from leaves of Diospyros kaki significantly inhibited fibroblasts proliferation (P < 0.05).	flavone	23-30	peroxiredoxin 5	Mus musculus	5-9
15272781-9	2004	CONCLUSIONS: Flavone from leaves of Diospyros kaki can significantly inhibit the adventitial fibroblasts proliferation stimulated by AOPP in vitro.	flavone	13-20	peroxiredoxin 5	Mus musculus	133-137
14757180-0	2004	Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells.	flavone	23-30	CF transmembrane conductance regulator	Homo sapiens	48-99
14757180-0	2004	Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells.	flavone	23-30	CF transmembrane conductance regulator	Homo sapiens	101-105
15084349-3	2004	6-Hydroxyflavone (6-HF), a synthetic flavone, also strongly inhibited 3beta-HSD activity but 5-HF, 7-HF and other natural flavones were less potent.	flavone	9-16	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	70-79
14976408-7	2004	In Caco-2 cells, quercetin and flavone increased early and late apoptosis parameters associated with a concomitant decline in pHi.	flavone	31-38	glucose-6-phosphate isomerase	Homo sapiens	126-129
14745173-3	2004	Lipopolysaccharide (LPS)-induced TNF-alpha production from macrophages was inhibited by treatment with flavone (luteolin, apigenin, and chrysin), flavonol (quercetin and myricetin), flavanonol (taxifolin), and anthocyanidin (cyanidin chloride) in vitro.	flavone	103-110	tumor necrosis factor	Mus musculus	33-42
14519054-1	2003	BACKGROUND: Flavopiridol, a novel flavone derivative, inhibits cyclin-dependent kinase-1.	flavone	34-41	cyclin dependent kinase 1	Homo sapiens	63-88
14638870-3	2003	To address the question as to whether there is any agonist for ERRs, our laboratory recently performed virtual ligand screening on ERRalpha that predicted flavone and isoflavone phytoestrogens to be ligands of this receptor.	flavone	155-162	estrogen related receptor alpha	Homo sapiens	131-139
14634213-4	2003	We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis.	flavone	62-69	NAD(P)H quinone dehydrogenase 1	Homo sapiens	84-88
14634213-4	2003	We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis.	flavone	62-69	NAD(P)H quinone dehydrogenase 1	Homo sapiens	141-145
14634213-4	2003	We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis.	flavone	62-69	tumor protein p53	Homo sapiens	177-180
14634213-4	2003	We now show that, like dicoumarol, several other coumarin and flavone inhibitors of NQO1 activity, which compete with NAD(P)H for binding to NQO1, induced ubiquitin-independent p53 degradation and inhibited wild-type p53-mediated apoptosis.	flavone	62-69	tumor protein p53	Homo sapiens	217-220
12869420-10	2003	Both small and large intestinal UGT enzyme activities were increased by quercetin, alpha-angelicalactone, coumarin, curcumin and flavone.	flavone	129-136	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	32-35
12869420-12	2003	Furthermore, dietary administration of alpha-angelicalactone and flavone, given individually or in combination, enhanced the UGT detoxification system in the liver and, to a lesser extent, in intestine.	flavone	65-72	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	125-128
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	alanyl aminopeptidase, membrane	Homo sapiens	29-32
12866025-3	2003	Caspase-3 activation as well as nuclear fragmentation, both indicative of apoptosis, were dose dependently inhibited by the NO-liberating agents sodium nitroprusside (SNP) or S-nitroso-N-acetyl-D,L-penicillamine (SNAP) when apoptosis was initiated by flavone with only minor effects on apoptosis when initiated by camptothecin.	flavone	251-258	caspase 3	Homo sapiens	0-9
12927873-8	2003	Pharmacophore modeling suggests a common binding mode for the flavones and other known CFTR activators at one of the nucleotide-binding sites, allowing for the rational development of more potent flavone analogues.	flavone	62-69	CF transmembrane conductance regulator	Homo sapiens	87-91
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	gamma-glutamyltransferase 1	Homo sapiens	228-233
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	alanyl aminopeptidase, membrane	Homo sapiens	33-37
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	dipeptidyl peptidase 4	Homo sapiens	285-290
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	membrane metalloendopeptidase	Homo sapiens	186-189
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	dipeptidyl peptidase 4	Homo sapiens	291-295
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	membrane metalloendopeptidase	Homo sapiens	190-194
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	cathepsin G	Homo sapiens	300-311
12930151-7	2003	The flavone 19b affinity for APN/CD13 is not recovered with other proteases such as matrix metalloproteinase-9 (MMP-9), angiotensin converting enzyme (ACE/CD143), neutral endopeptidase (NEP/CD10), gamma-glutamyl transpeptidase (CD224), or the serine proteases dipeptidyl peptidase IV (DPPIV/CD26) or cathepsin G.	flavone	4-11	inactive glutathione hydrolase 2	Homo sapiens	197-226
12565941-1	2003	A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity.	flavone	76-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	16-32
12644593-9	2003	Together, these data suggest that the differential agonist/antagonist activity of these flavone derivatives is caused by the efficacy of these flavonoids in eliciting an AhR conformation that recognizes regulatory response elements in a species-specific manner.	flavone	88-95	aryl-hydrocarbon receptor	Mus musculus	170-173
12663507-11	2003	Flavone, a backbone structure of PD98059, also induced nuclear translocation of C/EBP beta and C/EBP-mediated rGSTA2 gene induction.	flavone	0-7	CCAAT/enhancer binding protein beta	Rattus norvegicus	80-90
12663507-11	2003	Flavone, a backbone structure of PD98059, also induced nuclear translocation of C/EBP beta and C/EBP-mediated rGSTA2 gene induction.	flavone	0-7	CCAAT/enhancer binding protein gamma	Rattus norvegicus	80-85
12663507-11	2003	Flavone, a backbone structure of PD98059, also induced nuclear translocation of C/EBP beta and C/EBP-mediated rGSTA2 gene induction.	flavone	0-7	glutathione S-transferase alpha 2	Rattus norvegicus	110-116
12663507-13	2003	These results provide evidence that PD98059 and flavone induce nuclear translocation of C/EBP beta and activate the C/EBP-binding site in the rGSTA2 gene, which constitutes the distinct pathway for the enzyme induction irrespective of the inhibition of MKK1/ERK activity.	flavone	48-55	CCAAT/enhancer binding protein beta	Rattus norvegicus	88-98
12663507-13	2003	These results provide evidence that PD98059 and flavone induce nuclear translocation of C/EBP beta and activate the C/EBP-binding site in the rGSTA2 gene, which constitutes the distinct pathway for the enzyme induction irrespective of the inhibition of MKK1/ERK activity.	flavone	48-55	CCAAT/enhancer binding protein gamma	Rattus norvegicus	88-93
12663507-13	2003	These results provide evidence that PD98059 and flavone induce nuclear translocation of C/EBP beta and activate the C/EBP-binding site in the rGSTA2 gene, which constitutes the distinct pathway for the enzyme induction irrespective of the inhibition of MKK1/ERK activity.	flavone	48-55	glutathione S-transferase alpha 2	Rattus norvegicus	142-148
12663507-13	2003	These results provide evidence that PD98059 and flavone induce nuclear translocation of C/EBP beta and activate the C/EBP-binding site in the rGSTA2 gene, which constitutes the distinct pathway for the enzyme induction irrespective of the inhibition of MKK1/ERK activity.	flavone	48-55	Eph receptor B1	Rattus norvegicus	258-261
14598214-0	2003	A flavone from Manilkara indica as a specific inhibitor against aldose reductase in vitro.	flavone	2-9	aldo-keto reductase family 1 member B	Homo sapiens	64-80
12565941-1	2003	A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity.	flavone	76-83	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38
12112014-3	2002	The present study investigates regulation of BSP transcription in rat osteosarcoma ROS 17/2.8 cells by flavonoids: genistein (an inhibitor of protein tyrosine kinases), daidzein (an inactive compound of genistein), flavone, and flavanone.	flavone	215-222	integrin-binding sialoprotein	Rattus norvegicus	45-48
12588662-0	2003	Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages.	flavone	10-17	interleukin 1 beta	Mus musculus	33-50
12588662-0	2003	Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages.	flavone	10-17	interleukin 1 beta	Mus musculus	52-60
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	flavone	58-65	interleukin 1 beta	Mus musculus	181-198
12588662-3	2003	This study was designed to investigate the effect of five flavone derivatives variously substituted with hydroxyl groups (chrysin, galangin, kaempferol, quercetin and myricetin) on interleukin-1beta (IL-1beta) gene expression in stimulated RAW 264.7 macrophages.	flavone	58-65	interleukin 1 beta	Mus musculus	200-208
12457721-1	2003	Flavopiridol is a synthetic flavone that inhibits tumor growth by suppressing cyclin-dependent kinases (CDKs).	flavone	28-35	cyclin dependent kinase 2	Homo sapiens	104-108
12097658-6	2002	Using AP-1-luciferase stable human endometrial adenocarcinoma Ishikawa and human embryonic kidney (HEK) 293 cells, chalcone, flavone and apigenin all stimulated AP-1 activity.	flavone	125-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	6-10
12097658-6	2002	Using AP-1-luciferase stable human endometrial adenocarcinoma Ishikawa and human embryonic kidney (HEK) 293 cells, chalcone, flavone and apigenin all stimulated AP-1 activity.	flavone	125-132	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	161-165
12023936-3	2002	Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors of CYP1A2 activity relative to CYP1A1 activity.	flavone	23-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	44-50
12023936-3	2002	Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors of CYP1A2 activity relative to CYP1A1 activity.	flavone	23-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	165-171
12023936-4	2002	Molecular modelling of the CYP1A2 interaction with hydroxylated derivatives of flavone suggests that a number of hydrophobic residues of the substrate-binding domain engage in hydrogen bonding with such inhibitors.	flavone	79-86	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	27-33
12464670-3	2002	We screened 50,000 chemically diverse compounds for inhibition of cAMP/flavone-stimulated Cl(-) transport in epithelial cells expressing CFTR.	flavone	71-78	cystic fibrosis transmembrane conductance regulator	Mus musculus	137-141
12112014-4	2002	Genistein, daidzein, and flavone (50 microM) increased steady state levels of BSP mRNA about 1.7-fold at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, genistein increased luciferase activities within 12 h. Constructs including the promoter sequence nucleotides (nts) -116 to -43 (pLUC3) were found to enhance transcriptional activity approximately 2.6-fold in ROS 17/2.8 cells treated with genistein (50 microM).	flavone	25-32	integrin-binding sialoprotein	Rattus norvegicus	78-81
12112014-4	2002	Genistein, daidzein, and flavone (50 microM) increased steady state levels of BSP mRNA about 1.7-fold at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, genistein increased luciferase activities within 12 h. Constructs including the promoter sequence nucleotides (nts) -116 to -43 (pLUC3) were found to enhance transcriptional activity approximately 2.6-fold in ROS 17/2.8 cells treated with genistein (50 microM).	flavone	25-32	integrin-binding sialoprotein	Rattus norvegicus	166-169
12369712-7	2001	The flavone PD 098059 is known to bind to the inactive forms of MEK1 (MAPK/ERK-Kinase) thus preventing activation by upstream activators.	flavone	4-11	mitogen activated protein kinase kinase 1	Rattus norvegicus	64-68
11262417-0	2001	Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.	flavone	99-106	CF transmembrane conductance regulator	Homo sapiens	6-10
11322923-2	2001	Some flavonoids, such as flavone derivatives, have been reported previously to inhibit nitric oxide (NO) production by suppressing inducible nitric oxide synthase (iNOS) expression.	flavone	25-32	nitric oxide synthase 2, inducible	Mus musculus	131-162
11322923-2	2001	Some flavonoids, such as flavone derivatives, have been reported previously to inhibit nitric oxide (NO) production by suppressing inducible nitric oxide synthase (iNOS) expression.	flavone	25-32	nitric oxide synthase 2, inducible	Mus musculus	164-168
11479321-1	2001	The gene for the single subunit, rotenone-insensitive, and flavone-sensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae (NDI1) can completely restore the NADH dehydrogenase activity in mutant human cells that lack the essential mitochondrial DNA (mtDNA)-encoded subunit ND4.	flavone	59-66	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	143-147
11479321-1	2001	The gene for the single subunit, rotenone-insensitive, and flavone-sensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae (NDI1) can completely restore the NADH dehydrogenase activity in mutant human cells that lack the essential mitochondrial DNA (mtDNA)-encoded subunit ND4.	flavone	59-66	mitochondrially encoded NADH dehydrogenase 4	Homo sapiens	292-295
10826501-9	2000	ET-1-stimulated IL-6 secretion was also suppressed by diphenylene iodonium (40 microM), an inhibitor of flavon-containing enzymes such as NADH/NADPH oxidase.	flavone	104-110	endothelin 1	Homo sapiens	0-4
10825463-2	2000	This laboratory has studied a number of flavone derivatives for aryl hydrocarbon receptor (AhR) agonist and antagonist potential using cell-free and cell culture systems.	flavone	40-47	aryl-hydrocarbon receptor	Mus musculus	64-89
10825463-2	2000	This laboratory has studied a number of flavone derivatives for aryl hydrocarbon receptor (AhR) agonist and antagonist potential using cell-free and cell culture systems.	flavone	40-47	aryl-hydrocarbon receptor	Mus musculus	91-94
10919656-10	2000	The effects of flavone in HT-29 cells were associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor kappaB (NF-kappaB), and bcl-X(L).	flavone	15-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	132-148
10919656-10	2000	The effects of flavone in HT-29 cells were associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor kappaB (NF-kappaB), and bcl-X(L).	flavone	15-22	prostaglandin-endoperoxide synthase 2	Homo sapiens	150-155
10919656-10	2000	The effects of flavone in HT-29 cells were associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor kappaB (NF-kappaB), and bcl-X(L).	flavone	15-22	nuclear factor kappa B subunit 1	Homo sapiens	187-193
10919656-10	2000	The effects of flavone in HT-29 cells were associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor kappaB (NF-kappaB), and bcl-X(L).	flavone	15-22	nuclear factor kappa B subunit 1	Homo sapiens	195-204
10919656-10	2000	The effects of flavone in HT-29 cells were associated with changed mRNA levels of cell-cycle- and apoptosis-related genes including cyclooxygenase-2 (COX-2), nuclear transcription factor kappaB (NF-kappaB), and bcl-X(L).	flavone	15-22	BCL2 like 1	Homo sapiens	211-219
10826501-9	2000	ET-1-stimulated IL-6 secretion was also suppressed by diphenylene iodonium (40 microM), an inhibitor of flavon-containing enzymes such as NADH/NADPH oxidase.	flavone	104-110	interleukin 6	Homo sapiens	16-20
10782487-3	2000	The isolated flavone was tested for hypoglycemic activity in normal and alloxan-diabetic CD1 mice (25-30 g) were administered in doses of 10, 25 and 50 mg/kg body weight.	flavone	13-20	CD1 antigen complex	Mus musculus	89-92
10741717-4	2000	In this study, we show that endoreduplication and polyploidation can be prevented by inhibiting the cyclin-dependent kinases (Cdks) by flavopiridol, a synthetic flavone presently undergoing phase II clinical trials.	flavone	161-168	cyclin dependent kinase 2	Homo sapiens	126-130
10426807-7	1999	The AHR-containing murine hepatoma cell line 1c1c7 arrested following exposure to AHR agonist concentrations of flavone and alpha-naphthoflavone, but not TCDD.	flavone	112-119	aryl-hydrocarbon receptor	Mus musculus	4-7
10575734-3	1999	The phenyl ring of the flavone is not exactly perpendicular to the DHP ring.	flavone	23-30	dihydropyrimidinase	Rattus norvegicus	67-70
10666016-4	2000	After chromatography on silicagel and gel filtration on Sephadex, and using an in vitro anti-PLA2 assay-guided process, we have isolated and identified from the dichloromethane extract the flavone nepetin and four sesquiterpenes.	flavone	189-196	phospholipase A2, group V	Mus musculus	93-97
10426807-7	1999	The AHR-containing murine hepatoma cell line 1c1c7 arrested following exposure to AHR agonist concentrations of flavone and alpha-naphthoflavone, but not TCDD.	flavone	112-119	aryl-hydrocarbon receptor	Mus musculus	82-85
10443335-11	1999	The lower susceptibility of LLC-PK1 and MCF-7 cells towards growth arrest was even more pronounced in the case of the flavone baicalein.	flavone	118-125	prokineticin 1	Homo sapiens	32-35
10354494-6	1999	The NADH oxidase activity of the NDI1-transfected HEK 293 cells was not affected by rotenone but was inhibited by flavone.	flavone	114-121	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	33-37
10101030-0	1999	Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation.	flavone	0-7	aryl hydrocarbon receptor	Rattus norvegicus	95-120
9929167-3	1998	Using this method, the inhibitory effect of various flavonoids, including flavone, flavanone and isoflavone, on the human placental aromatase and 17beta-hydroxysteroid dehydrogenase was studied.	flavone	74-81	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	132-141
10234737-1	1999	In this study, the synthesis of new flavonoid derivatives, which possess a 1,4-dihydropyridine (1,4-DHP) moiety on the phenyl ring of flavone were realized.	flavone	134-141	dihydropyrimidinase	Homo sapiens	100-103
10573180-2	1999	The present study reports the inhibitory effects of six flavonoids, quercetin, genistein, daidzein, equol, (+)-catechin and flavone, on sulphation of p-nitrophenol, a model substrate for the P-form of PST (thermostable, TS) and dopamine, a model substrate for the M-form of PST (thermolabile, TL).	flavone	124-131	sulfotransferase family 1A member 1	Homo sapiens	201-204
10573180-2	1999	The present study reports the inhibitory effects of six flavonoids, quercetin, genistein, daidzein, equol, (+)-catechin and flavone, on sulphation of p-nitrophenol, a model substrate for the P-form of PST (thermostable, TS) and dopamine, a model substrate for the M-form of PST (thermolabile, TL).	flavone	124-131	sulfotransferase family 1A member 1	Homo sapiens	274-277
9929167-3	1998	Using this method, the inhibitory effect of various flavonoids, including flavone, flavanone and isoflavone, on the human placental aromatase and 17beta-hydroxysteroid dehydrogenase was studied.	flavone	74-81	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	146-181
9746563-6	1998	In addition, increased AM mRNA was observed following treatment of either C3H/OuJ or C3H/HeJ macrophages with soluble Toxoplasma gondii tachyzoite antigen or the synthetic flavone analog 5, 6-dimethylxanthenone-4-acetic acid.	flavone	172-179	adrenomedullin	Mus musculus	23-25
9804172-0	1998	Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells.	flavone	68-75	cyclin dependent kinase inhibitor 1A	Homo sapiens	51-54
9804172-0	1998	Promoter activation and following induction of the p21/WAF1 gene by flavone is involved in G1 phase arrest in A549 lung adenocarcinoma cells.	flavone	68-75	cyclin dependent kinase inhibitor 1A	Homo sapiens	55-59
9804172-5	1998	As a mechanism underlying the cell cycle arrest, flavone markedly increases the mRNA and protein levels of a universal inhibitor of cyclin-dependent kinase, p21/WAF1, and inhibits phosphorylation of retinoblastoma (RB) protein.	flavone	49-56	cyclin dependent kinase inhibitor 1A	Homo sapiens	157-160
9804172-5	1998	As a mechanism underlying the cell cycle arrest, flavone markedly increases the mRNA and protein levels of a universal inhibitor of cyclin-dependent kinase, p21/WAF1, and inhibits phosphorylation of retinoblastoma (RB) protein.	flavone	49-56	cyclin dependent kinase inhibitor 1A	Homo sapiens	161-165
9804172-5	1998	As a mechanism underlying the cell cycle arrest, flavone markedly increases the mRNA and protein levels of a universal inhibitor of cyclin-dependent kinase, p21/WAF1, and inhibits phosphorylation of retinoblastoma (RB) protein.	flavone	49-56	RB transcriptional corepressor 1	Homo sapiens	199-218
9804172-7	1998	In addition, 100 microM flavone significantly increases the promoter activity of the p21/WAF1 gene by 5-fold.	flavone	24-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	85-88
9804172-7	1998	In addition, 100 microM flavone significantly increases the promoter activity of the p21/WAF1 gene by 5-fold.	flavone	24-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	89-93
9804172-8	1998	These results suggest that the G1 phase arrest by flavone is due to p53-independent transcriptional induction of the p21/WAF1 gene and the subsequent dephosphorylation of RB protein.	flavone	50-57	tumor protein p53	Homo sapiens	68-71
9804172-8	1998	These results suggest that the G1 phase arrest by flavone is due to p53-independent transcriptional induction of the p21/WAF1 gene and the subsequent dephosphorylation of RB protein.	flavone	50-57	cyclin dependent kinase inhibitor 1A	Homo sapiens	117-120
9804172-8	1998	These results suggest that the G1 phase arrest by flavone is due to p53-independent transcriptional induction of the p21/WAF1 gene and the subsequent dephosphorylation of RB protein.	flavone	50-57	cyclin dependent kinase inhibitor 1A	Homo sapiens	121-125
9804172-8	1998	These results suggest that the G1 phase arrest by flavone is due to p53-independent transcriptional induction of the p21/WAF1 gene and the subsequent dephosphorylation of RB protein.	flavone	50-57	RB transcriptional corepressor 1	Homo sapiens	171-173
9763404-2	1998	The effects of flavone and five hydroxylated derivatives on the methoxyresorufin O-demethylase activity catalyzed by cDNA-expressed human cytochromes P450 (CYP)1A1 and 1A2 were examined.	flavone	15-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	138-171
9763404-3	1998	Flavone was a less potent inhibitor of CYP1A1 (IC50 = 0.14 microM) than CYP1A2 (IC50 = 0.066 microM).	flavone	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-45
9763404-4	1998	Four hydroxylated flavone derivatives (3-hydroxy-, 5-hydroxy-, 7-hydroxy-, and 3,7-dihydroxyflavone) were also potent inhibitors of CYP1A1 (IC50 < 0.1 microM) and CYP1A2 (IC50 < 0.3 microM).	flavone	18-25	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	132-138
9763404-4	1998	Four hydroxylated flavone derivatives (3-hydroxy-, 5-hydroxy-, 7-hydroxy-, and 3,7-dihydroxyflavone) were also potent inhibitors of CYP1A1 (IC50 < 0.1 microM) and CYP1A2 (IC50 < 0.3 microM).	flavone	18-25	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	166-172
9435150-0	1998	Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.	flavone	78-85	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	43-52
9495809-7	1998	Flavone and flavanone, two closely related structural analogs of PD98059, inhibited AHR transformation by TCDD with IC50 values similar to that obtained with PD98059.	flavone	0-7	aryl hydrocarbon receptor	Homo sapiens	84-87
9435150-4	1998	In combination with computer modeling, the binding characteristics and the structure requirement for flavone and isoflavone phytoestrogens to inhibit human aromatase were obtained.	flavone	101-108	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	156-165
9435150-0	1998	Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.	flavone	78-85	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	54-73
9435150-1	1998	Flavone and isoflavone phytoestrogens are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate.	flavone	0-7	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	120-129
9462835-5	1998	Flavone, which is a specific inhibitor of the S. cerevisiae NDI1, inhibited almost completely NADH oxidase and NADH-UQ1 reductase activities of NDI1-overexpressed membranes but scarcely inhibited these activities of the control membranes.	flavone	0-7	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	60-64
9462835-5	1998	Flavone, which is a specific inhibitor of the S. cerevisiae NDI1, inhibited almost completely NADH oxidase and NADH-UQ1 reductase activities of NDI1-overexpressed membranes but scarcely inhibited these activities of the control membranes.	flavone	0-7	NADH-ubiquinone reductase (H(+)-translocating) NDI1	Saccharomyces cerevisiae S288C	144-148
9324931-7	1997	In contrast, the RS and HNE inhibiting potencies of an essentially flavone-free and OPC-rich fraction C (21.3% of WS-1442) were significantly higher (inhibition of lipid peroxidation: IC50 0.3 microgram/ml; inhibition of HNE: IC50 0.84 microgram/ml) as those of WS-1442.	flavone	67-74	elastase, neutrophil expressed	Homo sapiens	24-27
9461039-7	1997	The data show that, of the flavonoids, the flavonols are the most effective inducers of quinone reductase activity in Hepa1c1c7 cells (kaempferol approximately galangin > quercetin > myricetin approximately apigenin (a flavone)) and that flavanols and flavans are ineffective.	flavone	225-232	crystallin, zeta	Mus musculus	88-105
9274802-5	1997	Co-administration of BHT (0.1%) and flavone (0.1%) increased markedly the levels of proteins and the activities of the enzymes related to the isozymes of CYP2A and CYP2B, while co-administration of BHA (0.2%) and flavanone (0.1%) elevated those related to CYP1A.	flavone	36-43	cytochrome P450, family 2, subfamily a	Mus musculus	154-159
9274802-5	1997	Co-administration of BHT (0.1%) and flavone (0.1%) increased markedly the levels of proteins and the activities of the enzymes related to the isozymes of CYP2A and CYP2B, while co-administration of BHA (0.2%) and flavanone (0.1%) elevated those related to CYP1A.	flavone	36-43	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	164-169
9357165-2	1997	While the three hepatotoxicants produced differential biochemical response, the flavone was able to restore biochemical alterations only in hepatocytes exposed to CCl4 and AAP induced toxicity.	flavone	80-87	C-C motif chemokine ligand 4	Rattus norvegicus	163-167
9208175-10	1997	For cis-anti- and cis-syn-DB[a,l]P tetrols, only a single conformer is detected by FLN spectroscopy.	flavone	83-86	synemin	Homo sapiens	22-25
9357165-3	1997	Silymarin at 0.4 mM was able to counteract lipid peroxidation and enzyme leakage induced by 3 mM CCl4 The flavone also offered protection by more than 60% in hepatocytes isolated from PB pre-treated rats where CCl4 at 2 mM produced enhanced toxicity over hepatocytes isolated from untreated control rats.	flavone	106-113	C-C motif chemokine ligand 4	Rattus norvegicus	97-101
9357165-3	1997	Silymarin at 0.4 mM was able to counteract lipid peroxidation and enzyme leakage induced by 3 mM CCl4 The flavone also offered protection by more than 60% in hepatocytes isolated from PB pre-treated rats where CCl4 at 2 mM produced enhanced toxicity over hepatocytes isolated from untreated control rats.	flavone	106-113	C-C motif chemokine ligand 4	Rattus norvegicus	210-214
8610110-3	1996	A novel flavone, (-)-cis-5,7-dihydroxyphenyl-8-[4-(3-hydroxy-1-methyl)piperidinyl] -4H-1-benzopyran-4-one hydrochloride hemihydrate (L868276), is a potent inhibitor of CDKs.	flavone	8-15	cyclin dependent kinase 1	Homo sapiens	168-172
9202751-3	1997	In the presence of flavonoids such as alpha-naphthoflavone and flavone, both CYP3A4 and CYP3A5 have also been shown to play a minor role in the activation of food-derived heterocyclic amines.	flavone	51-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	77-83
9202751-3	1997	In the presence of flavonoids such as alpha-naphthoflavone and flavone, both CYP3A4 and CYP3A5 have also been shown to play a minor role in the activation of food-derived heterocyclic amines.	flavone	51-58	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	88-94
8619243-3	1996	Immunoblot analysis indicated that flavone and tangeretin increased cytochrome P450 1A1, 1A2, and 2B1,2 forms, whereas flavanone only enhanced the cytochrome P450 2B isozymes.	flavone	35-42	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	68-87
8619243-4	1996	Northern blot study showed that flavone and tangeretin increased the level of the cytochrome P450 1A2 mRNAs.	flavone	32-39	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	82-101
8445932-1	1993	The effects of flavone (2-phenyl-1,4-benzopyrone), a modulator of the cytochrome P-450 monooxygenase system, on myocardial postischemic reperfusion recovery were examined in the present study.	flavone	15-22	cytochrome P-450	Oryctolagus cuniculus	70-86
7539338-1	1995	Nitric oxide (NO) is produced in mammals by the enzyme NO synthase (NOS) in response to a number of agents, including the experimental antitumour agent flavone acetic acid (FAA) and the cytokine tumour necrosis factor-alpha (TNF).	flavone	152-159	nitric oxide synthase 1, neuronal	Mus musculus	55-66
8155716-3	1994	A comparison between the mouse and human CYP1A2 revealed that alpha-naphthoflavone and flavone did not change the benzo[a]pyrene 3-hydroxylation activity of human CYP1A2 but inhibited its 7-ethoxyresorufin and 7-methoxyresorufin O-dealkylation activities.	flavone	75-82	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	41-47
8250970-0	1993	Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells.	flavone	65-72	cyclin dependent kinase 1	Homo sapiens	43-50
17236004-4	1993	The flavone-glucoside-cleaving beta-glucosidase (FGG) from the ligulate florets of chamomile was purified to electrophoretic homogeneity by the following procedure: ammonium sulphate fractionation, anion exchange on Mono Q, hydrophobic interaction chromatography on Bio-Gel TSK Phenyl-5-PW, and gel filtration on Superose 12.	flavone	4-11	tsukushi, small leucine rich proteoglycan	Homo sapiens	274-277
8445932-1	1993	The effects of flavone (2-phenyl-1,4-benzopyrone), a modulator of the cytochrome P-450 monooxygenase system, on myocardial postischemic reperfusion recovery were examined in the present study.	flavone	24-48	cytochrome P-450	Oryctolagus cuniculus	70-86
8445932-10	1993	The improvement resulting from flavone infusion was abolished completely by SKF 525-A, providing support for the interpretation that the effects of flavone were mediated through the cytochrome P-450 system.	flavone	31-38	cytochrome P-450	Oryctolagus cuniculus	182-198
8445932-10	1993	The improvement resulting from flavone infusion was abolished completely by SKF 525-A, providing support for the interpretation that the effects of flavone were mediated through the cytochrome P-450 system.	flavone	148-155	cytochrome P-450	Oryctolagus cuniculus	182-198
8445932-12	1993	We conclude that pretreatment with flavone represents a promising approach to myocardial protection that may be due to modulation of the myocardial cytochrome P-450 system.	flavone	35-42	cytochrome P-450	Oryctolagus cuniculus	148-164
1631168-1	1992	The crystal structure of the complex of 3",5"-dibromo-2",4,4",6-tetrahydroxyaurone, a flavone derivative, with human transthyretin (TTR), a serum thyroid hormone transport protein, has been determined and refined to R = 17.9% for data to 2.3-A resolution and provides a detailed description of a protein-bound flavonoid structure.	flavone	86-93	transthyretin	Homo sapiens	117-130
1403805-4	1992	Baicalein (10(-5) M), the prototype flavone, also increased sensitivity to exogenous norepinephrine, serotonin, arginine vasopressin and to the noncatecholamine alpha-1 and alpha-2 adrenergic agonists, cirazoline and tramazoline.	flavone	36-43	arginine vasopressin	Rattus norvegicus	121-132
1631168-1	1992	The crystal structure of the complex of 3",5"-dibromo-2",4,4",6-tetrahydroxyaurone, a flavone derivative, with human transthyretin (TTR), a serum thyroid hormone transport protein, has been determined and refined to R = 17.9% for data to 2.3-A resolution and provides a detailed description of a protein-bound flavonoid structure.	flavone	86-93	transthyretin	Homo sapiens	132-135
1385730-1	1992	The toxicity in rats and mice and the responses of 5 rat lung tumours, a rat rhabdomyosarcoma and a mouse colon tumour to flavone acetic acid, FAA, were studied.	flavone	122-129	fumarylacetoacetate hydrolase	Mus musculus	143-146
1643669-6	1992	Aryl hydrocarbon hydroxylase activity was moderately increased (1.5-1.8-fold) in microsomes prepared from rats fed flavone, tangeretin, 7,8-benzoflavone and 5,6-benzo-flavone.	flavone	115-122	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	0-28
34684783-3	2021	Acacetin, a flavone present in various plants, inhibits constitutive and inducible STAT3 activation in STAT3-activated DU145 prostate cancer cells.	flavone	12-19	signal transducer and activator of transcription 3	Homo sapiens	83-88
34597878-2	2021	This study was performed to investigate the protective effect of flavone apigenin through inhibition of GSK-3 and the involvement of this kinase in the inhibition of BACE1 expression and hyperphosphorylation of tau protein in an AD rat model.	flavone	65-72	beta-secretase 1	Rattus norvegicus	166-171
33798836-4	2021	In this study, a database containing 2017 flavone analogs was prepared and screened against SARS-CoV-2 Mpro using the molecular docking technique.	flavone	42-49	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	103-107
33798836-5	2021	According to the results, 371 flavone analogs exhibited good potency towards Mpro with docking scores less than -9.0 kcal/mol.	flavone	30-37	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	77-81
34843882-7	2022	Further study showed inhibitory effect of HGK on CYP enzymes was weaker than that of diosmetin, which may be related to the substitution of hydroxyl and methoxy in the A and B rings of the flavone skeleton.	flavone	189-196	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-52
34960014-0	2021	Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or Pseudomonas aeruginosa in Mice via Regulating the Expression and Phosphorylation of AKT.	flavone	8-15	thymoma viral proto-oncogene 1	Mus musculus	211-214
34960014-6	2021	In this study, the dietary flavone baicalein was identified as a novel inhibitor of HSP90 that targeted the N-terminal ATP binding pocket of HSP90 and hindered the chaperone cycle, resulting in AKT degradation.	flavone	27-34	heat shock protein, 3	Mus musculus	84-89
34960014-6	2021	In this study, the dietary flavone baicalein was identified as a novel inhibitor of HSP90 that targeted the N-terminal ATP binding pocket of HSP90 and hindered the chaperone cycle, resulting in AKT degradation.	flavone	27-34	heat shock protein, 3	Mus musculus	141-146
34960014-6	2021	In this study, the dietary flavone baicalein was identified as a novel inhibitor of HSP90 that targeted the N-terminal ATP binding pocket of HSP90 and hindered the chaperone cycle, resulting in AKT degradation.	flavone	27-34	thymoma viral proto-oncogene 1	Mus musculus	194-197
34256329-0	2021	Natural flavone tricin exerted anti-inflammatory activity in macrophage via NF-kappaB pathway and ameliorated acute colitis in mice.	flavone	8-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-85
34224301-0	2021	Roles of cytochrome P450 2A6 in the oxidation of flavone, 4 -hydroxyflavone, and 4 -, 3 -, and 2 -methoxyflavones by human liver microsomes.	flavone	49-56	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	9-28
34224301-1	2021	Nine forms of recombinant cytochrome P450 (P450 or CYP) enzymes were used to study roles of individual P450 enzymes in the oxidation of flavone and some other flavonoids, 4 -hydroxyflavone and 4 -, 3 -, and 2 -methoxyflavones, by human liver microsomes using LC-MS/MS analysis.As has been reported previously (Nagayoshi et al., Xenobiotica 50, 1158-1169, 2020), 4 -, 3 -, and 2 -methoxyflavones were preferentially O-demethylated by human liver P450 enzymes to form 4 -, 3 -, and 2 -hydroxylated flavones and also 3 ,4 -dihydroxyflavone from the former two substrates.In comparisons of product formation by oxidation of these methoxylated flavones, CYP2A6 was found to be a major enzyme catalyzing flavone 4 - and 3 -hydroxylations by human liver microsomes but did not play significant roles in 2 -hydroxylation of flavone, O-demethylations of three methoxylated flavones, and the oxidation of 4 -hydroxyflavone to 3 ,4 -dihydroxyflavone.The effects of anti-CYP2A6 IgG and chemical P450 inhibitors suggested that different P450 enzymes, as well as CYP2A6, catalyzed oxidation of these flavonoids at different positions by liver microsomes.These studies suggest that CYP2A6 catalyzes flavone 4 - and 3 -hydroxylations in human liver microsomes and that other P450 enzymes have different roles in oxidizing these flavonoids.	flavone	136-143	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	649-655
34224301-1	2021	Nine forms of recombinant cytochrome P450 (P450 or CYP) enzymes were used to study roles of individual P450 enzymes in the oxidation of flavone and some other flavonoids, 4 -hydroxyflavone and 4 -, 3 -, and 2 -methoxyflavones, by human liver microsomes using LC-MS/MS analysis.As has been reported previously (Nagayoshi et al., Xenobiotica 50, 1158-1169, 2020), 4 -, 3 -, and 2 -methoxyflavones were preferentially O-demethylated by human liver P450 enzymes to form 4 -, 3 -, and 2 -hydroxylated flavones and also 3 ,4 -dihydroxyflavone from the former two substrates.In comparisons of product formation by oxidation of these methoxylated flavones, CYP2A6 was found to be a major enzyme catalyzing flavone 4 - and 3 -hydroxylations by human liver microsomes but did not play significant roles in 2 -hydroxylation of flavone, O-demethylations of three methoxylated flavones, and the oxidation of 4 -hydroxyflavone to 3 ,4 -dihydroxyflavone.The effects of anti-CYP2A6 IgG and chemical P450 inhibitors suggested that different P450 enzymes, as well as CYP2A6, catalyzed oxidation of these flavonoids at different positions by liver microsomes.These studies suggest that CYP2A6 catalyzes flavone 4 - and 3 -hydroxylations in human liver microsomes and that other P450 enzymes have different roles in oxidizing these flavonoids.	flavone	136-143	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	959-965
34224301-1	2021	Nine forms of recombinant cytochrome P450 (P450 or CYP) enzymes were used to study roles of individual P450 enzymes in the oxidation of flavone and some other flavonoids, 4 -hydroxyflavone and 4 -, 3 -, and 2 -methoxyflavones, by human liver microsomes using LC-MS/MS analysis.As has been reported previously (Nagayoshi et al., Xenobiotica 50, 1158-1169, 2020), 4 -, 3 -, and 2 -methoxyflavones were preferentially O-demethylated by human liver P450 enzymes to form 4 -, 3 -, and 2 -hydroxylated flavones and also 3 ,4 -dihydroxyflavone from the former two substrates.In comparisons of product formation by oxidation of these methoxylated flavones, CYP2A6 was found to be a major enzyme catalyzing flavone 4 - and 3 -hydroxylations by human liver microsomes but did not play significant roles in 2 -hydroxylation of flavone, O-demethylations of three methoxylated flavones, and the oxidation of 4 -hydroxyflavone to 3 ,4 -dihydroxyflavone.The effects of anti-CYP2A6 IgG and chemical P450 inhibitors suggested that different P450 enzymes, as well as CYP2A6, catalyzed oxidation of these flavonoids at different positions by liver microsomes.These studies suggest that CYP2A6 catalyzes flavone 4 - and 3 -hydroxylations in human liver microsomes and that other P450 enzymes have different roles in oxidizing these flavonoids.	flavone	136-143	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	1049-1055
34224301-1	2021	Nine forms of recombinant cytochrome P450 (P450 or CYP) enzymes were used to study roles of individual P450 enzymes in the oxidation of flavone and some other flavonoids, 4 -hydroxyflavone and 4 -, 3 -, and 2 -methoxyflavones, by human liver microsomes using LC-MS/MS analysis.As has been reported previously (Nagayoshi et al., Xenobiotica 50, 1158-1169, 2020), 4 -, 3 -, and 2 -methoxyflavones were preferentially O-demethylated by human liver P450 enzymes to form 4 -, 3 -, and 2 -hydroxylated flavones and also 3 ,4 -dihydroxyflavone from the former two substrates.In comparisons of product formation by oxidation of these methoxylated flavones, CYP2A6 was found to be a major enzyme catalyzing flavone 4 - and 3 -hydroxylations by human liver microsomes but did not play significant roles in 2 -hydroxylation of flavone, O-demethylations of three methoxylated flavones, and the oxidation of 4 -hydroxyflavone to 3 ,4 -dihydroxyflavone.The effects of anti-CYP2A6 IgG and chemical P450 inhibitors suggested that different P450 enzymes, as well as CYP2A6, catalyzed oxidation of these flavonoids at different positions by liver microsomes.These studies suggest that CYP2A6 catalyzes flavone 4 - and 3 -hydroxylations in human liver microsomes and that other P450 enzymes have different roles in oxidizing these flavonoids.	flavone	136-143	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	1167-1173
34161895-0	2021	GLUT4 translocation in C2C12 myoblasts and primary mouse hepatocytes by an antihyperglycemic flavone from Tillandsia usneoides.	flavone	93-100	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	0-5
34160206-7	2021	Most of the flavone aglycones function through NF-kappaB, MAPK, and JNK-STAT pathways, and their possible cell binding targets are kinase, aryl hydrocarbon receptor (AhR), G-protein coupled receptors, and estrogen receptors.	flavone	12-19	nuclear factor kappa B subunit 1	Homo sapiens	47-56
34160206-7	2021	Most of the flavone aglycones function through NF-kappaB, MAPK, and JNK-STAT pathways, and their possible cell binding targets are kinase, aryl hydrocarbon receptor (AhR), G-protein coupled receptors, and estrogen receptors.	flavone	12-19	mitogen-activated protein kinase 8	Homo sapiens	68-71
34160206-7	2021	Most of the flavone aglycones function through NF-kappaB, MAPK, and JNK-STAT pathways, and their possible cell binding targets are kinase, aryl hydrocarbon receptor (AhR), G-protein coupled receptors, and estrogen receptors.	flavone	12-19	aryl hydrocarbon receptor	Homo sapiens	139-164
34160206-7	2021	Most of the flavone aglycones function through NF-kappaB, MAPK, and JNK-STAT pathways, and their possible cell binding targets are kinase, aryl hydrocarbon receptor (AhR), G-protein coupled receptors, and estrogen receptors.	flavone	12-19	aryl hydrocarbon receptor	Homo sapiens	166-169
34068281-6	2021	The silencing of NQO2 strongly reduced flavone-induced autophagic flux, although it increased basal LC3-II levels in HepG2 cells.	flavone	39-46	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	17-21
34068281-7	2021	Both flavones induced AMP kinase (AMPK) activation, while its reduction by AMPK beta (PRKAB1) silencing inhibited flavone-induced autophagy.	flavone	114-121	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	86-92
34068281-10	2021	These findings imply that NQO2 works as a flavone receptor mediating autophagy and may contribute to other hepatic effects of flavonoids.	flavone	42-49	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	26-30
35007929-7	2022	The protein level of iNOS expression was significantly improved in all immunopotentiator groups, except for the astragalus flavone group.	flavone	123-130	inositol-3-phosphate synthase 1	Homo sapiens	21-25
35583593-10	2022	Besides, silencing of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) abolished the ISO-induced HO-1 upregulation and mitochondrial benefits induced by this flavone on the CPF-challenged cells.	flavone	185-192	NFE2 like bZIP transcription factor 2	Homo sapiens	47-90
35583593-10	2022	Besides, silencing of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) abolished the ISO-induced HO-1 upregulation and mitochondrial benefits induced by this flavone on the CPF-challenged cells.	flavone	185-192	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
35583593-10	2022	Besides, silencing of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) abolished the ISO-induced HO-1 upregulation and mitochondrial benefits induced by this flavone on the CPF-challenged cells.	flavone	185-192	heme oxygenase 1	Homo sapiens	124-128
34099595-0	2022	A newly synthesized flavone from luteolin escapes from COMT-catalyzed methylation and inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages via JNK,P38 and NF-kappaB signaling pathways.	flavone	20-27	catechol-O-methyltransferase	Homo sapiens	55-59
34099595-0	2022	A newly synthesized flavone from luteolin escapes from COMT-catalyzed methylation and inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages via JNK,P38 and NF-kappaB signaling pathways.	flavone	20-27	mitogen-activated protein kinase 8	Homo sapiens	163-166
34099595-0	2022	A newly synthesized flavone from luteolin escapes from COMT-catalyzed methylation and inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages via JNK,P38 and NF-kappaB signaling pathways.	flavone	20-27	nuclear factor kappa B subunit 1	Homo sapiens	175-184
34099595-4	2022	Without a catechol ring in the chemical structure, this new flavone could escape from the COMT-catalyzed methylation, thus affording the potential to exert its functions in the original form when administrated in the organism.	flavone	60-67	catechol-O-methyltransferase	Homo sapiens	90-94
3164998-8	1988	Structure activity studies exhibited that the inhibitory potencies of the flavonoids for tyrosine kinases of pp130fps and insulin receptor correlated with the number of hydroxy residues on the flavone rings (gamma = 0.974 and 0.926, respectively), whereas the hydroxylation influenced to a lesser extent the inhibitory potencies for serine/threonine protein kinase.	flavone	193-200	insulin receptor	Homo sapiens	122-138
35111229-0	2022	Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling.	flavone	7-14	gap junction protein beta 2	Homo sapiens	73-77
35111229-0	2022	Citrus Flavone Tangeretin Inhibits CRPC Cell Proliferation by Regulating Cx26, AKT, and AR Signaling.	flavone	7-14	AKT serine/threonine kinase 1	Homo sapiens	79-82
2730676-10	1989	Analysis of these structure-activity data revealed a model of the minimal essential features required for PKC inhibition by flavonoids: a coplanar flavone structure with free hydroxyl substituents at the 3", 4" and 7-positions.	flavone	147-154	protein kinase C, gamma	Rattus norvegicus	106-109
3366417-3	1988	In contrast, 0.25% flavone caused significant increases in relative liver weight, microsomal and cytoplasmic proteins, and cytochrome P-450 content.	flavone	19-26	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	123-139
3121205-4	1988	In addition, the microsomal activation was reduced efficiently by known inhibitors of cytochrome P-450-mediated reactions such as 7,8-benzoflavone, ellipticine and flavone.	flavone	139-146	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	86-102
4059325-0	1985	Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase.	flavone	0-7	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	34-62
4059325-2	1985	We have utilized a series of 18 flavone modulators of AHH to distinguish and probe for different cytochrome P-450 isozymes in liver microsomes from control and 3-methylcholanthrene (MC)-injected rats.	flavone	32-39	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	54-57
6609910-6	1984	The presence of a double bond at position C-2-3 in the flavone and flavonol aglycones, a keto group at C-4, B ring hydroxylation and/or a free hydroxyl group at C-3 may be associated with activity.	flavone	55-62	complement C2	Homo sapiens	42-45
33877504-9	2021	Indeed, flavone, isoflavone aglycones, non-prenylated chalcones and glycycoumarin were found to be TRPM8 inhibitors.	flavone	8-15	transient receptor potential cation channel subfamily M member 8	Homo sapiens	99-104
6626210-5	1983	These findings together with the results obtained with flavone on the metabolism of benzo(a)pyrene by various microsomal preparations suggest a parallel induction of multiple forms of cytochrome P-450 as observed in mammalian liver under identical condition.	flavone	55-62	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	184-200
6270135-2	1981	Benzo[a]pyrene metabolism was stimulated more than 5-fold by the addition of 600 microM flavone to a reconstituted monooxygenase system consisting of NADPH, cytochrome P-450 reductase, dilauroylphosphatidylcholine, and cytochrome P-450LM3c or cytochrome P-450LM4.	flavone	88-95	cytochrome P450 1A2	Oryctolagus cuniculus	243-262
6270135-3	1981	In contrast, an inhibitory effect of flavone on benzo[a]pyrene metabolism was observed when cytochrome P-450LM2, cytochrome P-450LM3b, or cytochrome P-450LM6 was used in the reconstituted system.	flavone	37-44	cytochrome P450 2B4	Oryctolagus cuniculus	92-111
6270135-3	1981	In contrast, an inhibitory effect of flavone on benzo[a]pyrene metabolism was observed when cytochrome P-450LM2, cytochrome P-450LM3b, or cytochrome P-450LM6 was used in the reconstituted system.	flavone	37-44	cytochrome P450 1A1	Oryctolagus cuniculus	138-157
31899683-8	2021	Among the synthesized compounds, in flavone derivatives such as HFc (7-hydroxy-3-(4-methoxy phenyl)-4H-chromen-4-one), HFd (2-(2,4-di methoxy-phenyl)-7-hydroxy-4H-chromen-4-one) and HFe (7-hydroxy-2-(thiophen-2-yl)-4H-chromen-4-one) were produced higher potency.	flavone	36-43	homeostatic iron regulator	Homo sapiens	182-185
33939580-3	2021	In alpha-glucosidase inhibitory assay, the EtOAc extract and its flavone and biflavone derivatives possessed the significant IC50 range of 9.17-97.53 microM, as compared with that of the positive control acarbose (249 microM).	flavone	65-72	sucrase-isomaltase	Homo sapiens	3-20
33585872-7	2021	A QTL near P1 (Pericarp color1) was found for both flavone content and flavanol-anthocyanin condensed forms.	flavone	51-58	myb-related protein P	Zea mays	11-30
34022252-1	2021	7,8-dihydroxyflavone (DHF), a naturally-occurring plant-based flavone, is a high-affinity tyrosine kinase receptor B (TrkB) agonist, and a bioactive molecule of therapeutic interest for neuronal survival, differentiation, synaptic plasticity and neurogenesis.	flavone	13-20	neurotrophic receptor tyrosine kinase 2	Homo sapiens	90-116
34022252-1	2021	7,8-dihydroxyflavone (DHF), a naturally-occurring plant-based flavone, is a high-affinity tyrosine kinase receptor B (TrkB) agonist, and a bioactive molecule of therapeutic interest for neuronal survival, differentiation, synaptic plasticity and neurogenesis.	flavone	13-20	neurotrophic receptor tyrosine kinase 2	Homo sapiens	118-122
32945582-4	2021	Hispidulin (HIS), is a biologically active natural flavone with versatile biological and pharmacological activities.	flavone	51-58	histidine ammonia-lyase	Homo sapiens	0-10
32945582-4	2021	Hispidulin (HIS), is a biologically active natural flavone with versatile biological and pharmacological activities.	flavone	51-58	histidine ammonia-lyase	Homo sapiens	12-15
31899683-10	2021	CONCLUSIONS: The flavone and flavanone scaffolds were posses their excellent inhibitory action over the Cyclooxygenase-2 and acts as a potential anti-inflammatory agents.	flavone	17-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	104-120
33519472-2	2020	The aim of this study was to investigate whether the natural flavone acacetin could protect against endothelial injury induced by high glucose and attenuate diabetes-accelerated atherosclerosis in streptozotocin-(STZ) induced diabetic ApoE-/- mice model.	flavone	61-68	apolipoprotein E	Mus musculus	235-239
32141421-0	2021	Synthesis, Molecular Docking and Biological Evaluation of Novel Flavone Derivatives as Potential Anticancer Agents Targeting Akt.	flavone	64-71	AKT serine/threonine kinase 1	Homo sapiens	125-128
32141421-13	2021	CONCLUSION: The synthesized flavone derivatives and particularly compound 3b exhibited promising anticancer activity through Akt inhibition.	flavone	28-35	AKT serine/threonine kinase 1	Homo sapiens	125-128
33185419-0	2020	Polyphenol Honokiol and Flavone 2",3",4"-Trihydroxyflavone Differentially Interact with alpha-Synuclein at Distinct Phases of Aggregation.	flavone	24-31	synuclein alpha	Homo sapiens	88-103
33398976-6	2020	The results of fermentation showed that SmF3H can catalyze the flavone 3-hydroxylation reaction, and its catalytic efficiency was significantly higher than that of commonly used SlF3H from Solanum lycopersicum.	flavone	63-70	flavanone 3-dioxygenase	Solanum lycopersicum	178-183
33348871-2	2020	METHODS: We examined the inhibitory effects of a variety of flavone and flavonol derivatives on ODC enzymatic activity, and performed in silico molecular docking of baicalein, 7,8-dihydroxyflavone and myricetin to the whole dimer of human ODC to investigate the possible binding site of these compounds on ODC.	flavone	60-67	ornithine decarboxylase 1	Homo sapiens	96-99
33348871-7	2020	CONCLUSIONS: Therefore, we suggest that the flavone or flavonol derivatives baicalein, 7,8-dihydroxyflavone, and myricetin are potent chemopreventive and chemotherapeutic agents that target ODC.	flavone	44-51	ornithine decarboxylase 1	Homo sapiens	190-193
32899576-0	2020	Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity.	flavone	53-60	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-97
33291755-0	2020	Molecular Docking Simulations on Histone Deacetylases (HDAC)-1 and -2 to Investigate the Flavone Binding.	flavone	89-96	histone deacetylase 1	Homo sapiens	33-69
33291755-5	2020	Our data have revealed how flavone, and other two flavones previously investigated, i.e., apigenin and luteolin, can interact as ligands with HDAC1 and 2 at the active site binding pocket.	flavone	27-34	histone deacetylase 1	Homo sapiens	142-153
33381046-0	2020	Astragalus Flavone Ameliorates Atherosclerosis and Hepatic Steatosis Via Inhibiting Lipid-Disorder and Inflammation in apoE-/- Mice.	flavone	11-18	apolipoprotein E	Mus musculus	119-123
32823005-0	2020	Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.	flavone	30-37	signal transducer and activator of transcription 3	Homo sapiens	102-107
32899576-0	2020	Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity.	flavone	53-60	beta-secretase 1	Homo sapiens	102-108
32703423-0	2020	Citrus flavone tangeretin is a potential insulin sensitizer targeting hepatocytes through suppressing MEK-ERK1/2 pathway.	flavone	7-14	midkine	Mus musculus	102-105
33133535-2	2020	We have previously shown that the dietary flavone apigenin (4",5,7-trihydroxyflavone) upregulates CD26/DPPIV on colon cells.	flavone	42-49	dipeptidyl peptidase 4	Homo sapiens	98-102
33133535-2	2020	We have previously shown that the dietary flavone apigenin (4",5,7-trihydroxyflavone) upregulates CD26/DPPIV on colon cells.	flavone	42-49	dipeptidyl peptidase 4	Homo sapiens	103-108
32703423-0	2020	Citrus flavone tangeretin is a potential insulin sensitizer targeting hepatocytes through suppressing MEK-ERK1/2 pathway.	flavone	7-14	mitogen-activated protein kinase 3	Mus musculus	106-112
31997462-0	2020	Flavones as tyrosinase inhibitors: kinetic studies in vitro and in silico.	flavone	0-8	tyrosinase	Homo sapiens	12-22
31997462-8	2020	The polymethoxy flavones 4 and 5 exhibited the strongest tyrosinase inhibitory effect with the half maximal inhibitory concentration (IC50 ) values of 131.92 +- 1.75 muM and 99.87 +- 2.38 muM respectively.	flavone	4-24	tyrosinase	Homo sapiens	57-67
31997462-10	2020	Docking studies indicated that methoxy groups on 4 and 5 caused steric hindrance which prevented alternative binding modes in the tyrosinase; the methoxy groups on the B-ring of these flavones faced the catalytic site in the enzyme.	flavone	184-192	tyrosinase	Homo sapiens	130-140
31676069-0	2020	Nobiletin and related polymethoxylated flavones bind to and inhibit the nuclear export factor Exportin-1 in NK leukemia cell line KHYG-1.	flavone	22-47	exportin 1	Homo sapiens	94-104
31978681-0	2020	Search for non-acidic ALR2 inhibitors: Evaluation of flavones as targeted agents for the management of diabetic complications.	flavone	53-61	aldo-keto reductase family 1 member B	Homo sapiens	22-26
31978681-7	2020	Initially, flavones reported by our research group were screened by those two pharmacophore models to obtain hits with an optimum affinity for the catalytic domain of both ALR2 and SDH.	flavone	11-19	aldo-keto reductase family 1 member B	Homo sapiens	172-176
31978681-7	2020	Initially, flavones reported by our research group were screened by those two pharmacophore models to obtain hits with an optimum affinity for the catalytic domain of both ALR2 and SDH.	flavone	11-19	sorbitol dehydrogenase	Homo sapiens	181-184
31968628-5	2020	The results indicated that the carbon-carbon double bond group at the C2, C3 sites and the carbonyl group at the C4 sites of flavones were essential for thrombin inhibition, whereas the methoxy and O-glycosyl groups reduced thrombin inhibition.	flavone	125-133	coagulation factor II, thrombin	Homo sapiens	153-161
30993586-0	2020	Midkine silencing enhances the anti-prostate cancer stem cell activity of the flavone apigenin: cooperation on signaling pathways regulated by ERK, p38, PTEN, PARP, and NF-kappaB.	flavone	78-85	midkine	Homo sapiens	0-7
31991371-0	2020	Natural flavone tricetin suppresses oxidized LDL-induced endothelial inflammation mediated by Egr-1.	flavone	8-15	early growth response 1	Homo sapiens	94-99
31785807-0	2020	Flavone inhibited proliferation of T-ALL by promoting c-Cbl-induced ubiquitinylation and degradation of Notch1.	flavone	0-7	Cbl proto-oncogene	Homo sapiens	54-59
31785807-0	2020	Flavone inhibited proliferation of T-ALL by promoting c-Cbl-induced ubiquitinylation and degradation of Notch1.	flavone	0-7	notch receptor 1	Homo sapiens	104-110
31785807-7	2020	In this study, we demonstrated that flavone inhibited cell proliferation by down-regulating Notch1 signal pathway in CCRF-CEM and Molt-4 T-ALL cells.	flavone	36-43	notch receptor 1	Homo sapiens	92-98
31785807-8	2020	Flavone-mediated upregulation of c-Cbl level results in the increase in its interaction with ICN1, further caused ICN1 ubiquitinylation and degradation.	flavone	0-7	Cbl proto-oncogene	Homo sapiens	33-38
31785807-9	2020	Knockdown of c-Cbl reversed flavone-induced down-regulation of ICN1 and inhibition of cell proliferation in T-ALL cells.	flavone	28-35	Cbl proto-oncogene	Homo sapiens	13-18
31785807-10	2020	In short, this study indicated that flavone exerted resistance to T-ALL by promoting c-Cbl-induced ubiquitinylation and degradation of ICN1.	flavone	36-43	Cbl proto-oncogene	Homo sapiens	85-90
31676069-7	2020	Consistent with this, nobiletin and related PMFs induced the nuclear retention of NF-kappaB, a transcription factor that promotes GrB and IFN-gamma expression.	flavone	44-48	nuclear factor kappa B subunit 1	Homo sapiens	82-91
31676069-7	2020	Consistent with this, nobiletin and related PMFs induced the nuclear retention of NF-kappaB, a transcription factor that promotes GrB and IFN-gamma expression.	flavone	44-48	granzyme B	Homo sapiens	130-133
31676069-7	2020	Consistent with this, nobiletin and related PMFs induced the nuclear retention of NF-kappaB, a transcription factor that promotes GrB and IFN-gamma expression.	flavone	44-48	interferon gamma	Homo sapiens	138-147
31676069-8	2020	PMFs also induced the nuclear retention of the tumor suppressor protein p53, a known XPO1 cargo protein, resulting in KHYG-1 cell cycle arrest.	flavone	0-4	tumor protein p53	Homo sapiens	72-75
31676069-8	2020	PMFs also induced the nuclear retention of the tumor suppressor protein p53, a known XPO1 cargo protein, resulting in KHYG-1 cell cycle arrest.	flavone	0-4	exportin 1	Homo sapiens	85-89
31676069-9	2020	Collectively, these results suggest that PMFs modulate KHYG-1 function, at least in part, by inhibiting XPO1.	flavone	41-45	exportin 1	Homo sapiens	104-108
31676069-2	2020	We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell line KHYG-1 and increased level of the cytotoxic protein granzyme B (GrB) and the cytokine interferon-gamma (IFN-gamma).	flavone	32-36	granzyme B	Homo sapiens	188-198
31676069-2	2020	We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell line KHYG-1 and increased level of the cytotoxic protein granzyme B (GrB) and the cytokine interferon-gamma (IFN-gamma).	flavone	32-36	granzyme B	Homo sapiens	200-203
31676069-2	2020	We previously demonstrated that PMFs such as nobiletin potentiate the cytolytic activity of the human leukemic natural killer cell line KHYG-1 and increased level of the cytotoxic protein granzyme B (GrB) and the cytokine interferon-gamma (IFN-gamma).	flavone	32-36	interferon gamma	Homo sapiens	240-249
31894062-3	2019	Among tested flavonoids, the para substituted chloro containing flavonol (OF2) and flavone (F2) revealed a considerable in-vitro AChE and BuChE % inhibition with an IC50 values.	flavone	83-90	acetylcholinesterase	Mus musculus	129-133
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	flavone	179-187	aryl hydrocarbon receptor	Homo sapiens	88-91
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	flavone	179-187	complement C2	Homo sapiens	174-177
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	flavone	179-187	aryl hydrocarbon receptor	Homo sapiens	313-316
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	flavone	200-208	aryl hydrocarbon receptor	Homo sapiens	88-91
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	flavone	200-208	complement C2	Homo sapiens	174-177
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	flavone	200-208	complement C3	Homo sapiens	192-195
31621310-7	2019	These results coupled with simulation studies modeling flavonoid interaction within the AhR binding pocket demonstrate that the orientation of the substituted phenyl ring at C-2 (flavones) or C-3 (isoflavones) on the common 4-H-chromen-4-one ring strongly influences the activities of isoflavones and flavones as AhR agonists.	flavone	200-208	aryl hydrocarbon receptor	Homo sapiens	313-316
31250712-0	2019	Flavone of Hippophae (H-flavone) lowers atherosclerotic risk factors via upregulation of the adipokine C1q/tumor necrosis factor-related protein 6 (CTRP6) in macrophages.	flavone	0-7	C1q and tumor necrosis factor related protein 6	Mus musculus	148-153
31598976-0	2020	Total flavones of Rhododendron simsii Planch flower protect rat hippocampal neuron from hypoxia-reoxygenation injury via activation of BKCa channel.	flavone	6-14	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	135-139
31598976-1	2020	OBJECTIVES: To study the effects of total flavones of Rhododendra simsii Planch flower (TFR) on hypoxia/reoxygenation (H/R) injury in rat hippocampal neurons and its underlying mechanism.	flavone	42-50	transferrin receptor	Rattus norvegicus	88-91
31598976-7	2020	CONCLUSIONS: Total flavones of R. simsii Planch flower had a protective effect against H/R injury in rat hippocampal neuron, and activation of BKCa channel may contribute to the neuroprotection.	flavone	19-27	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	143-147
31782497-2	2019	Two isoprenylated flavones that activated AMPK were isolated.	flavone	4-26	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	42-46
31621310-4	2019	The structure-activity relationships for the flavonoids were complex and both response and cell context specific; however, there was significant variability in the AhR activities of the isomeric substituted isoflavones and flavones.	flavone	210-218	aryl hydrocarbon receptor	Homo sapiens	164-167
31621310-6	2019	In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive.	flavone	57-64	aryl hydrocarbon receptor	Homo sapiens	120-123
31621310-6	2019	In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive.	flavone	57-64	aryl hydrocarbon receptor	Homo sapiens	183-186
31621310-6	2019	In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive.	flavone	57-64	aryl hydrocarbon receptor	Homo sapiens	183-186
31621310-6	2019	In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive.	flavone	83-90	aryl hydrocarbon receptor	Homo sapiens	120-123
31621310-6	2019	In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive.	flavone	83-90	aryl hydrocarbon receptor	Homo sapiens	183-186
31621310-6	2019	In contrast, both 5,7-dihydroxy-4-methoxy substituted isoflavone (biochanin A) and flavone (acacetin) induced all three AhR-responsive genes; 4",5,7-trimethoxyisoflavone was a potent AhR agonist, and the isomeric flavone was AhR-inactive.	flavone	83-90	aryl hydrocarbon receptor	Homo sapiens	183-186
31557620-1	2019	Two beta-secreatase (BACE1) inhibitors from natural products (cinnamic acid and flavone) were linked to furnish potent, cell permeable BACE1 inhibitors with noncompetitive mode of inhibition, with the assistance of saturated transfer difference (STD)-NMR technique.	flavone	80-87	beta-secretase 1	Homo sapiens	21-26
31557620-1	2019	Two beta-secreatase (BACE1) inhibitors from natural products (cinnamic acid and flavone) were linked to furnish potent, cell permeable BACE1 inhibitors with noncompetitive mode of inhibition, with the assistance of saturated transfer difference (STD)-NMR technique.	flavone	80-87	beta-secretase 1	Homo sapiens	135-140
30707413-0	2019	Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2alpha-ATF4-CHOP Pathway.	flavone	20-27	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	153-157
30707413-0	2019	Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2alpha-ATF4-CHOP Pathway.	flavone	20-27	eukaryotic translation initiation factor 2A	Homo sapiens	158-167
30707413-0	2019	Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2alpha-ATF4-CHOP Pathway.	flavone	20-27	activating transcription factor 4	Homo sapiens	168-172
30707413-0	2019	Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2alpha-ATF4-CHOP Pathway.	flavone	20-27	DNA damage inducible transcript 3	Homo sapiens	173-177
30964977-0	2019	Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes.	flavone	13-20	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	113-128
31059072-0	2019	Total flavone of Abelmoschus manihot ameliorates Crohn"s disease by regulating the NF-kappaB and MAPK signaling pathways.	flavone	6-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-92
30964977-2	2019	In order to better understand the metabolism of these flavonoids in humans, we examined the oxidation of flavone, 5-hydroxyflavone (5OHF), and 57diOHF to various products by human cytochrome P450 (P450 or CYP) and liver microsomal enzymes.	flavone	105-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	180-195
30964977-2	2019	In order to better understand the metabolism of these flavonoids in humans, we examined the oxidation of flavone, 5-hydroxyflavone (5OHF), and 57diOHF to various products by human cytochrome P450 (P450 or CYP) and liver microsomal enzymes.	flavone	105-112	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	197-208
30048196-0	2019	Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes.	flavone	41-48	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	52-71
30048196-2	2019	CYP2A6 was highly active in oxidizing flavanone to form flavone, 2"-hydroxy-, 4"-, and 6-hydroxyflavanones and in oxidizing flavone to form mono- and di-hydroxylated products, such as mono-hydroxy flavones M6, M7, and M11 and di-hydroxy flavones M3, M4, and M5.	flavone	56-63	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
30048196-2	2019	CYP2A6 was highly active in oxidizing flavanone to form flavone, 2"-hydroxy-, 4"-, and 6-hydroxyflavanones and in oxidizing flavone to form mono- and di-hydroxylated products, such as mono-hydroxy flavones M6, M7, and M11 and di-hydroxy flavones M3, M4, and M5.	flavone	124-131	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
30048196-3	2019	Liver microsomes prepared from human sample HH2, defective in coumarin 7-hydroxylation activity, were very inefficient in forming 2"-hydroxyflavanone from flavanone and a mono-hydroxylated product, M6, from flavone.	flavone	207-214	fibroblast growth factor receptor 1	Homo sapiens	44-47
30048196-6	2019	These results suggest that CYP2A6 catalyzes site-specific oxidation of (racemic) flavanone and also flavone in human liver microsomes.	flavone	100-107	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	27-33
31278699-8	2019	The flavone derivatives showed moderate to weak inhibition against LOX.	flavone	4-11	lysyl oxidase	Mus musculus	67-70
30594450-0	2019	alpha-Glucosidase inhibition activity and in silico study of 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one, a synthetic derivative of flavone.	flavone	134-141	sucrase-isomaltase	Homo sapiens	0-17
30594450-1	2019	A synthetic flavone derivative 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one (BDC) was synthesized by the one pot reaction method and assessed for alpha-glucosidase inhibitory activity.	flavone	12-19	sucrase-isomaltase	Homo sapiens	147-164
30933784-6	2019	Comparison of the MAO-B inhibitory effects of the flavone-indole hybrids and aurone-indole hybrids showed that most of the aurone-indole hybrids were stronger inhibitors than the corresponding flavone-indole hybrids.	flavone	50-57	monoamine oxidase B	Homo sapiens	18-23
30933784-6	2019	Comparison of the MAO-B inhibitory effects of the flavone-indole hybrids and aurone-indole hybrids showed that most of the aurone-indole hybrids were stronger inhibitors than the corresponding flavone-indole hybrids.	flavone	193-200	monoamine oxidase B	Homo sapiens	18-23
31424673-0	2019	A flavone, Wogonin from Scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and G2/M cell cycle arrest via modulating the PI3K/AKT and STAT3 signalling pathways.	flavone	2-9	AKT serine/threonine kinase 1	Homo sapiens	195-198
31424673-0	2019	A flavone, Wogonin from Scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and G2/M cell cycle arrest via modulating the PI3K/AKT and STAT3 signalling pathways.	flavone	2-9	signal transducer and activator of transcription 3	Homo sapiens	203-208
30129150-0	2018	The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells.	flavone	12-19	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
30594625-4	2019	The results demonstrated that the C-3 and C-7 hydroxyl groups on the flavone skeleton would enhance UGT1A1 inhibition, while flavonoid glycosides displayed weaker inhibitory effects than their corresponding aglycones.	flavone	69-76	complement C3	Homo sapiens	34-37
30594625-4	2019	The results demonstrated that the C-3 and C-7 hydroxyl groups on the flavone skeleton would enhance UGT1A1 inhibition, while flavonoid glycosides displayed weaker inhibitory effects than their corresponding aglycones.	flavone	69-76	complement C7	Homo sapiens	42-45
30594625-4	2019	The results demonstrated that the C-3 and C-7 hydroxyl groups on the flavone skeleton would enhance UGT1A1 inhibition, while flavonoid glycosides displayed weaker inhibitory effects than their corresponding aglycones.	flavone	69-76	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	100-106
30594677-0	2019	Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2.	flavone	19-26	ATP binding cassette subfamily B member 1	Homo sapiens	98-103
30594677-0	2019	Novel chalcone and flavone derivatives as selective and dual inhibitors of the transport proteins ABCB1 and ABCG2.	flavone	19-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	108-113
30679715-6	2019	Vesicles from yeast expressing AtABCC2 also transported flavone and flavonol glucosides.	flavone	56-63	multidrug resistance-associated protein 2	Arabidopsis thaliana	31-38
30552007-0	2019	Flavone-based natural product agents as new lysine-specific demethylase 1 inhibitors exhibiting cytotoxicity against breast cancer cells in vitro.	flavone	0-7	lysine demethylase 1A	Homo sapiens	44-73
31057098-4	2019	Out of all, the most potent DPP-IV inhibitor were found to be resveratrol, luteolin, apigenin and flavone having activity in nanomolar range.	flavone	98-105	dipeptidyl peptidase 4	Homo sapiens	28-34
30932078-0	2019	3D-QSAR, Docking, ADME/Tox studies on Flavone analogs reveal anticancer activity through Tankyrase inhibition.	flavone	38-45	thymocyte selection associated high mobility group box	Homo sapiens	23-26
30932078-0	2019	3D-QSAR, Docking, ADME/Tox studies on Flavone analogs reveal anticancer activity through Tankyrase inhibition.	flavone	38-45	tankyrase	Homo sapiens	89-98
30932078-11	2019	This study is offering the first example of a computationally-driven tool for prioritization and discovery of novel flavone scaffold for tankyrase receptor affinity with high therapeutic windows.	flavone	116-123	tankyrase	Homo sapiens	137-146
30508555-1	2019	alpha-Naphthoflavone (alphaNF) is a prototype flavone, also known as a modulator of aryl hydrocarbon receptor (AhR).	flavone	13-20	aryl-hydrocarbon receptor	Mus musculus	84-109
30508555-1	2019	alpha-Naphthoflavone (alphaNF) is a prototype flavone, also known as a modulator of aryl hydrocarbon receptor (AhR).	flavone	13-20	aryl-hydrocarbon receptor	Mus musculus	111-114
29310511-0	2019	Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone.	flavone	69-76	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-19
29310511-2	2019	We previously reported that flavone and flavanone interact spectrally with cytochrome P450 (P450 or CYP) 2A6 and 2A13 and other human P450s and inhibit catalytic activities of these P450 enzymes.	flavone	28-35	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	92-117
29310511-3	2019	In this study, we studied abilities of CYP1A1, 1A2, 1B1, 2A6, 2A13, 2C9 and 3A4 to oxidize flavone and flavanone.	flavone	91-98	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-45
29310511-10	2019	CYP2A6 catalyzed flavanone to produce flavone at a turnover rate of 0.72 min-1 that was ~3-fold higher than that catalyzed by CYP2A13 (0.29 min-1).	flavone	38-45	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	0-6
29310511-12	2019	These results indicate that CYP2A6 and other human P450s have important roles in metabolizing flavone and flavanone, two unsubstituted flavonoids, present in dietary foods.	flavone	94-101	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	28-34
31984880-4	2019	METHODS: Scientific publications referring to natural and synthetic flavones in relation to their biological activities were hand-searched in databases such as SciFinder, PubMed (National Library of Medicine), Science Direct, Wiley, ACS, SciELO, Springer, among others.	flavone	68-76	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	233-236
30416442-3	2018	In Caco-2 and transfected MDCKII cell models, flavone baicalein significantly inhibited the efflux of silybin as a BCRP and MRP2 inhibitor.	flavone	46-53	ATP binding cassette subfamily G member 2	Canis lupus familiaris	115-119
30416442-3	2018	In Caco-2 and transfected MDCKII cell models, flavone baicalein significantly inhibited the efflux of silybin as a BCRP and MRP2 inhibitor.	flavone	46-53	ATP binding cassette subfamily C member 2	Canis lupus familiaris	124-128
29953467-4	2018	Therefore, the interaction features of monomeric U-shape Abeta17-42 with natural flavonoids including myricetin, morin and flavone at different mole ratios were comprehensively studied to recognize the mechanism of Abeta monomer instability using molecular dynamics (MD) simulations.	flavone	123-130	amyloid beta precursor protein	Homo sapiens	57-62
30405745-0	2018	Total Flavone of Rhododendron Improves Cerebral Ischemia Injury by Activating Vascular TRPV4 to Induce Endothelium-Derived Hyperpolarizing Factor-Mediated Responses.	flavone	6-13	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	87-92
30071202-0	2018	Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.	flavone	22-29	NLR family, pyrin domain containing 3	Mus musculus	90-95
30083786-4	2018	Luteolin (3",4",5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway.	flavone	32-39	NFE2 like bZIP transcription factor 2	Homo sapiens	137-180
30083786-4	2018	Luteolin (3",4",5,7-tetrahydroxyflavone, LUT) is a widespread flavone known to have antioxidant and cytoprotective properties related to nuclear factor erythroid 2-related factor 2-(Nrf2) pathway.	flavone	32-39	NFE2 like bZIP transcription factor 2	Homo sapiens	182-186
30122880-0	2018	Total flavone of Abelmoschus manihot suppresses epithelial-mesenchymal transition via interfering transforming growth factor-beta1 signaling in Crohn"s disease intestinal fibrosis.	flavone	6-13	transforming growth factor, beta 1	Rattus norvegicus	98-130
29857184-1	2018	Quercetin, a common dietary flavone, is a competitive inhibitor of glucose uptake and is also thought to be transported into cells by GLUT1.	flavone	28-35	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	134-139
29552226-0	2018	The co-treatment of metformin with flavone synergistically induces apoptosis through inhibition of PI3K/AKT pathway in breast cancer cells.	flavone	35-42	AKT serine/threonine kinase 1	Homo sapiens	104-107
26919834-1	2018	OBJECTIVE: To investigate the effect of total flavone of haw leaves (TFHL) on the expression of nuclear factor erythroid-2 related factor (Nrf2) and other related factors in nonalcoholic steatohepatitis (NASH) rats induced by high-fat diet and then to further discuss the mechanism of TFHL"s prevention against NASH.	flavone	46-53	NFE2 like bZIP transcription factor 2	Rattus norvegicus	139-143
29745222-0	2018	New Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of beta-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer"s Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase.	flavone	4-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	277-297
29867499-0	2018	The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway.	flavone	12-19	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	103-107
29867499-0	2018	The Natural Flavone Acacetin Confers Cardiomyocyte Protection Against Hypoxia/Reoxygenation Injury via AMPK-Mediated Activation of Nrf2 Signaling Pathway.	flavone	12-19	NFE2 like bZIP transcription factor 2	Rattus norvegicus	131-135
29139477-0	2018	A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation.	flavone	10-17	NLR family, pyrin domain containing 6	Mus musculus	74-79
29139477-2	2018	Herein, we provide evidence that the anti-inflammatory and antiproliferative effect of the flavone apigenin relies on the regulation of the gut microbiota by the NOD-like receptor family pyrin domain containing 6 (Nlrp6).	flavone	91-98	NLR family, pyrin domain containing 6	Mus musculus	214-219
29641499-5	2018	The B-2 cultivar had the highest antioxidant potential than others because it contained the highest levels of polyphenols, especially anthocyanin, flavone, and phenolic acid; furthermore, this cultivar displayed anti-tumor effects against the human lung adenocarcinoma cell line A549, human hepatoma cell line Bel7402, human cancer colorectal adenoma cell line HCT-8, and HT-29 human colon cancer cell line.	flavone	147-154	immunoglobulin kappa variable 5-2	Homo sapiens	4-7
29552226-7	2018	These results indicated that dietary flavone may potentiate breast cancer cell apoptosis induced by metformin, and PI3K/AKT is involved in regulating MDMX/p53 signaling.	flavone	37-44	tumor protein p53	Homo sapiens	155-158
30108939-1	2018	In a continued effort to develop potent cholesterol esterase (CEase) inhibitors, a series of 5,6-benzoflavone derivatives was rationally designed and synthesized by changing the position of the benzene ring attached to the flavone skeleton in previously reported 7,8-benzoflavones.	flavone	102-109	carboxyl ester lipase	Homo sapiens	40-60
29600676-0	2018	[Osteopractic total flavone promoting rat extra-articular tendon-bone healing through mTOR pathway].	flavone	20-27	mechanistic target of rapamycin kinase	Rattus norvegicus	86-90
29427283-11	2018	To summarize, NGN, a dietary flavone, has the potential to counteract MPTP-induced dopaminergic degeneration by regulating SYN pathology, neuroinflammation, and oxidative stress.	flavone	29-36	synemin, intermediate filament protein	Mus musculus	123-126
30108939-1	2018	In a continued effort to develop potent cholesterol esterase (CEase) inhibitors, a series of 5,6-benzoflavone derivatives was rationally designed and synthesized by changing the position of the benzene ring attached to the flavone skeleton in previously reported 7,8-benzoflavones.	flavone	102-109	carboxyl ester lipase	Homo sapiens	62-67
32188225-6	2017	Compared with the BMF group, the CSA and flavone groups had significantly higher and expressions of caspase family proteins (all P<0.05) whereas the levels of Cyt C, PS, Ca2+, and expressions of Bak and Bax were reduced (all P<0.05).	flavone	41-48	BCL2-antagonist/killer 1	Mus musculus	195-198
29162309-6	2018	This fact indicates that the presence of a flavone or chromone residue influences the SAR of these series of products, and that flexible molecules can find different productive binding modes with the P-gp recognition site.	flavone	43-50	phosphoglycolate phosphatase	Homo sapiens	200-204
28980448-0	2018	Dietary Flavone Tectochrysin Exerts Anti-Inflammatory Action by Directly Inhibiting MEK1/2 in LPS-Primed Macrophages.	flavone	8-15	mitogen-activated protein kinase kinase 1	Mus musculus	84-90
28882412-6	2017	Recent screening of a chemical library has identified a flavone derivative, 7,8-dihydroxyflavone (7,8-DHF), a small-molecule that crosses the blood-brain barrier and binds with high affinity and specificity to the TrkB receptor.	flavone	56-63	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	214-218
32188225-6	2017	Compared with the BMF group, the CSA and flavone groups had significantly higher and expressions of caspase family proteins (all P<0.05) whereas the levels of Cyt C, PS, Ca2+, and expressions of Bak and Bax were reduced (all P<0.05).	flavone	41-48	BCL2-associated X protein	Mus musculus	203-206
32188225-7	2017	More importantly, the flavone group had higher levels of Cyt C, Ca2+ and expressions of Bak and Bax compared with the CSA group (all P<0.05), while the levels of PS and caspase family proteins were reduced (all P<0.05).	flavone	22-29	BCL2-antagonist/killer 1	Mus musculus	88-91
32188225-7	2017	More importantly, the flavone group had higher levels of Cyt C, Ca2+ and expressions of Bak and Bax compared with the CSA group (all P<0.05), while the levels of PS and caspase family proteins were reduced (all P<0.05).	flavone	22-29	BCL2-associated X protein	Mus musculus	96-99
27666135-4	2017	The most potent flavone MAO inhibitor studied is Az2k19 (1.6 mum for MAO-A, 2.1 mum for MAO-B), while Az1k15 and Az2k15 displayed better selectivity toward MAO-B (SI &gt; 10).	flavone	16-23	monoamine oxidase A	Homo sapiens	69-83
28731171-0	2017	Protective role of Pollen Typhae total flavone against the palmitic acid-induced impairment of glucose-stimulated insulin secretion involving GPR40 signaling in INS-1 cells.	flavone	39-46	free fatty acid receptor 1	Rattus norvegicus	142-147
29955703-13	2017	GEN and flavone antagonists of AhR may be useful for reactivation of BRCA1 and ERalpha via CpG demethylation in ERalpha-negative breast cancer cells harboring constitutively active AhR.	flavone	8-15	aryl hydrocarbon receptor	Homo sapiens	31-34
29955703-13	2017	GEN and flavone antagonists of AhR may be useful for reactivation of BRCA1 and ERalpha via CpG demethylation in ERalpha-negative breast cancer cells harboring constitutively active AhR.	flavone	8-15	BRCA1 DNA repair associated	Homo sapiens	69-74
29955703-13	2017	GEN and flavone antagonists of AhR may be useful for reactivation of BRCA1 and ERalpha via CpG demethylation in ERalpha-negative breast cancer cells harboring constitutively active AhR.	flavone	8-15	estrogen receptor 1	Homo sapiens	79-86
29955703-13	2017	GEN and flavone antagonists of AhR may be useful for reactivation of BRCA1 and ERalpha via CpG demethylation in ERalpha-negative breast cancer cells harboring constitutively active AhR.	flavone	8-15	estrogen receptor 1	Homo sapiens	112-119
29955703-13	2017	GEN and flavone antagonists of AhR may be useful for reactivation of BRCA1 and ERalpha via CpG demethylation in ERalpha-negative breast cancer cells harboring constitutively active AhR.	flavone	8-15	aryl hydrocarbon receptor	Homo sapiens	181-184
28119082-4	2017	Herein, we investigated the inhibitory activity of fisetin and flavone against CYP1B1 using estrogen E2 as substrate in vitro to reveal structure-activity relationship between structure of flavonoids and inhibition.	flavone	63-70	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	79-85
28367715-4	2017	Here we show that the flavone-loaded Ca-polyP microparticles are readily taken up by phOSB, resulting in the accumulation of polyP around the nuclei and the formation of intracellular vesicles containing the ALP.	flavone	22-29	alkaline phosphatase, placental	Homo sapiens	208-211
27666135-4	2017	The most potent flavone MAO inhibitor studied is Az2k19 (1.6 mum for MAO-A, 2.1 mum for MAO-B), while Az1k15 and Az2k15 displayed better selectivity toward MAO-B (SI &gt; 10).	flavone	16-23	monoamine oxidase B	Homo sapiens	88-93
27397410-3	2016	The thiolation could be conveniently directed to C-8 for flavone, flavonol, dihydroflavone, and isoflavone derivatives or to C-7 for aurone derivatives by employing the isopropyl ethers of flavonoids bearing free OH groups at the C-5 or C-4 positions.	flavone	57-64	homeobox C8	Homo sapiens	49-52
27814566-3	2016	Baicalin may serve as a template for designing flavone-based LSD1 inhibitors.	flavone	47-54	lysine demethylase 1A	Homo sapiens	61-65
28367926-7	2017	In multiple regression analysis, the dietary flavone intake was negatively associated with systolic blood pressure, triglyceride, TG/HDL-cholesterol, and homesostatic model assessment of insulin resistance.	flavone	45-52	insulin	Homo sapiens	187-194
27778136-9	2017	Quantitative reverse transcriptase-polymerase chain reaction assay demonstrated that the transcription of HMGCR under both flavone treatments was reduced.	flavone	123-130	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	106-111
26935193-3	2016	In this study, we investigated flavone (the core structure of flavonoids)-induced regulation on ROS generation and DLC1/RhoA pathway in MCF-7 and MDA-MB-231 breast cancer cells and explored whether flavone-induced upregulation of DLC1 is mediated by ROS.	flavone	31-38	DLC1 Rho GTPase activating protein	Homo sapiens	115-119
26935193-0	2016	Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells.	flavone	0-7	DLC1 Rho GTPase activating protein	Homo sapiens	35-39
27498833-5	2016	The flavone 7,4"-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1beta and TNF-alpha.	flavone	4-11	interleukin 1 beta	Mus musculus	204-212
27498833-5	2016	The flavone 7,4"-di-O-methylisoscutellarein showed anti-inflammatory activity by inhibiting neutrophils recruitment in a mice model of pleurisy and by decreasing significantly the production of cytokines IL-1beta and TNF-alpha.	flavone	4-11	tumor necrosis factor	Mus musculus	217-226
26935193-3	2016	In this study, we investigated flavone (the core structure of flavonoids)-induced regulation on ROS generation and DLC1/RhoA pathway in MCF-7 and MDA-MB-231 breast cancer cells and explored whether flavone-induced upregulation of DLC1 is mediated by ROS.	flavone	31-38	ras homolog family member A	Homo sapiens	120-124
26935193-3	2016	In this study, we investigated flavone (the core structure of flavonoids)-induced regulation on ROS generation and DLC1/RhoA pathway in MCF-7 and MDA-MB-231 breast cancer cells and explored whether flavone-induced upregulation of DLC1 is mediated by ROS.	flavone	31-38	DLC1 Rho GTPase activating protein	Homo sapiens	230-234
26935193-4	2016	Our results showed that flavone decreased ROS production and inhibited cell migration through DLC1/RhoA pathway.	flavone	24-31	DLC1 Rho GTPase activating protein	Homo sapiens	94-98
26935193-4	2016	Our results showed that flavone decreased ROS production and inhibited cell migration through DLC1/RhoA pathway.	flavone	24-31	ras homolog family member A	Homo sapiens	99-103
26935193-5	2016	To further investigate the role of ROS in flavone-induced regulation on DLC1/RhoA pathway, hydrogen peroxide was added to restore the ROS levels.	flavone	42-49	DLC1 Rho GTPase activating protein	Homo sapiens	72-76
26935193-5	2016	To further investigate the role of ROS in flavone-induced regulation on DLC1/RhoA pathway, hydrogen peroxide was added to restore the ROS levels.	flavone	42-49	ras homolog family member A	Homo sapiens	77-81
26935193-0	2016	Flavone inhibits migration through DLC1/RhoA pathway by decreasing ROS generation in breast cancer cells.	flavone	0-7	ras homolog family member A	Homo sapiens	40-44
26931451-8	2016	Insulin and homoeostasis model assessment for insulin resistance (HOMA-IR) were inversely associated with flavone (for insulin, -3 18 % change; 95 % CI -5 85, -0 44; for HOMA-IR, -3 10 % change; 95 % CI -5 93, -0 19) and isoflavone intakes (for insulin, -3 11 % change; 95 % CI -5 46, -0 70; for HOMA-IR, -4 01 % change; 95 % CI -6 67, -1 27).	flavone	106-113	insulin	Homo sapiens	0-7
26935193-6	2016	Flavone-induced upregulation of DLC1 expression, downregulation of RhoA activity, and inhibition of cell migration were all restrained by hydrogen peroxide.	flavone	0-7	DLC1 Rho GTPase activating protein	Homo sapiens	32-36
26935193-6	2016	Flavone-induced upregulation of DLC1 expression, downregulation of RhoA activity, and inhibition of cell migration were all restrained by hydrogen peroxide.	flavone	0-7	ras homolog family member A	Homo sapiens	67-71
26935193-7	2016	We also found that flavone increased DLC1 stability by inhibiting DLC1 protein degradation in breast cancer cells.	flavone	19-26	DLC1 Rho GTPase activating protein	Homo sapiens	37-41
26935193-7	2016	We also found that flavone increased DLC1 stability by inhibiting DLC1 protein degradation in breast cancer cells.	flavone	19-26	DLC1 Rho GTPase activating protein	Homo sapiens	66-70
26935193-8	2016	In summary, our study demonstrated that flavone inhibited cell migration through DLC1/RhoA pathway by decreasing ROS generation and suppressed DLC1 degradation in MCF-7 and MDA-MB-231 breast cancer cells.	flavone	40-47	DLC1 Rho GTPase activating protein	Homo sapiens	81-85
26935193-8	2016	In summary, our study demonstrated that flavone inhibited cell migration through DLC1/RhoA pathway by decreasing ROS generation and suppressed DLC1 degradation in MCF-7 and MDA-MB-231 breast cancer cells.	flavone	40-47	ras homolog family member A	Homo sapiens	86-90
26935193-8	2016	In summary, our study demonstrated that flavone inhibited cell migration through DLC1/RhoA pathway by decreasing ROS generation and suppressed DLC1 degradation in MCF-7 and MDA-MB-231 breast cancer cells.	flavone	40-47	DLC1 Rho GTPase activating protein	Homo sapiens	143-147
26931451-8	2016	Insulin and homoeostasis model assessment for insulin resistance (HOMA-IR) were inversely associated with flavone (for insulin, -3 18 % change; 95 % CI -5 85, -0 44; for HOMA-IR, -3 10 % change; 95 % CI -5 93, -0 19) and isoflavone intakes (for insulin, -3 11 % change; 95 % CI -5 46, -0 70; for HOMA-IR, -4 01 % change; 95 % CI -6 67, -1 27).	flavone	106-113	insulin	Homo sapiens	46-53
26931451-8	2016	Insulin and homoeostasis model assessment for insulin resistance (HOMA-IR) were inversely associated with flavone (for insulin, -3 18 % change; 95 % CI -5 85, -0 44; for HOMA-IR, -3 10 % change; 95 % CI -5 93, -0 19) and isoflavone intakes (for insulin, -3 11 % change; 95 % CI -5 46, -0 70; for HOMA-IR, -4 01 % change; 95 % CI -6 67, -1 27).	flavone	106-113	insulin	Homo sapiens	119-126
26931451-8	2016	Insulin and homoeostasis model assessment for insulin resistance (HOMA-IR) were inversely associated with flavone (for insulin, -3 18 % change; 95 % CI -5 85, -0 44; for HOMA-IR, -3 10 % change; 95 % CI -5 93, -0 19) and isoflavone intakes (for insulin, -3 11 % change; 95 % CI -5 46, -0 70; for HOMA-IR, -4 01 % change; 95 % CI -6 67, -1 27).	flavone	106-113	insulin	Homo sapiens	119-126
28044092-7	2016	The specific flavone backbone conformation and the degree of polarity seem to play an important role for the interaction with PDIA3.	flavone	13-20	protein disulfide isomerase family A member 3	Homo sapiens	126-131
26855338-3	2016	The study found that cardamonin, a flavone compound, could efficiently inhibit the expression of TSP50 in both mRNA and protein levels.	flavone	35-42	serine protease 50	Homo sapiens	97-102
27012618-0	2016	Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1.	flavone	70-77	DnaJ heat shock protein family (Hsp40) member B1	Homo sapiens	112-155
26669576-3	2015	In vitro binding assays using recombinant mouse PrP (rMoPrP) aggregates revealed that the 4-dimethylamino-substituted styrylchromone derivative (SC-NMe2) had higher in vitro binding affinity (Kd = 24.5 nM) and capacity (Bmax = 36.3 pmol/nmol protein) than three other flavonoid derivatives (flavone, chalcone, and aurone).	flavone	291-298	NME/NM23 nucleoside diphosphate kinase 2	Mus musculus	148-152
26675309-9	2015	Flavone, apigenin and luteolin induced forkhead box O3 (FOXO3a) expression by inhibiting Phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB)/Akt.	flavone	0-7	forkhead box O3	Homo sapiens	56-62
26675309-9	2015	Flavone, apigenin and luteolin induced forkhead box O3 (FOXO3a) expression by inhibiting Phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB)/Akt.	flavone	0-7	phosphoinositide-3-kinase regulatory subunit 1	Homo sapiens	89-114
26675309-9	2015	Flavone, apigenin and luteolin induced forkhead box O3 (FOXO3a) expression by inhibiting Phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB)/Akt.	flavone	0-7	AKT serine/threonine kinase 1	Homo sapiens	144-147
25978649-0	2015	The flavone apigenin blocks nuclear translocation of sterol regulatory element-binding protein-2 in the hepatic cells WRL-68.	flavone	4-11	sterol regulatory element binding transcription factor 2	Homo sapiens	53-96
26675309-9	2015	Flavone, apigenin and luteolin induced forkhead box O3 (FOXO3a) expression by inhibiting Phosphoinositide 3-kinase (PI3K) and protein kinase B (PKB)/Akt.	flavone	0-7	AKT serine/threonine kinase 1	Homo sapiens	149-152
26435478-3	2015	Our multistep approach of molecular modeling and direct binding has led to the identification of plant flavone apigenin as a specific IKKalpha inhibitor.	flavone	103-110	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	134-142
26302339-0	2015	The Flavone Luteolin Suppresses SREBP-2 Expression and Post-Translational Activation in Hepatic Cells.	flavone	4-11	sterol regulatory element binding transcription factor 2	Homo sapiens	32-39
26302339-7	2015	This flavone also prevented the nuclear translocation of SREBP-2.	flavone	5-12	sterol regulatory element binding transcription factor 2	Homo sapiens	57-64
26302339-11	2015	A reporter gene assay also verified that the transcription of SREBF2 was weakened in response to this flavone.	flavone	102-109	sterol regulatory element binding transcription factor 2	Homo sapiens	62-68
26068596-0	2015	A step toward simplified detection of serum albumin on SDS-PAGE using an environment-sensitive flavone sensor.	flavone	95-102	albumin	Homo sapiens	38-51
26068596-1	2015	In this study, we report a series of novel flavone-based sensors that exhibit a superior fluorescence response when interacting with serum albumin in real serum samples and in acrylamide gels.	flavone	43-50	albumin	Homo sapiens	133-146
26187393-2	2015	Vitexin (5, 7, 4-trihydroxyflavone-8-glucoside), an HIF-1alpha inhibitor, is a c-glycosylated flavone that has been identified in medicinal plants.	flavone	27-34	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	52-62
26604691-0	2015	Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats.	flavone	20-27	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
26222491-7	2015	All the mutants showed higher activities for flavone and alpha-naphthoflavone compared with CYP2A6.1.	flavone	45-52	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	92-98
26421240-5	2015	Recently, we identified five outstanding inhibitors of insulin amyloid-like fibril formation among the pool of 265 commercially available flavone derivatives.	flavone	138-145	insulin	Homo sapiens	55-62
26388667-0	2015	Wogonin, a plant flavone from Scutellariae radix, attenuated ovalbumin-induced airway inflammation in mouse model of asthma via the suppression of IL-4/STAT6 signaling.	flavone	17-24	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	61-70
26275107-4	2015	Overall, this work may facilitate construction of a library of hispidulin-derived compounds for investigating the structure-activity relationship of flavone-based Pim-1 inhibitors.	flavone	149-156	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	163-168
25199800-8	2015	MRG-IFC-2 hydrolysed isoflavone C- and O-glycosides, as well as the flavone O-glycoside apigetrin, but could not hydrolyse the flavone C-glycosidic bond of vitexin.	flavone	24-31	MAS1 proto-oncogene like, G protein-coupled receptor	Homo sapiens	0-3
25978649-8	2015	Reporter gene assay revealed that the transactivation of sterol responsive element (SRE)-containing 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) promoter was suppressed by the flavone.	flavone	180-187	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	100-140
25978649-8	2015	Reporter gene assay revealed that the transactivation of sterol responsive element (SRE)-containing 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) promoter was suppressed by the flavone.	flavone	180-187	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	142-147
26423875-6	2015	Among the flavonoid components of these herbal medicines, flavone and chrysin exhibited high ligand activity for AhR.	flavone	58-65	aryl hydrocarbon receptor	Homo sapiens	113-116
25972379-0	2015	Beneficial Effect of Flavone Derivatives on Abeta-Induced Memory Deficit Is Mediated by Peroxisome Proliferator-Activated Receptor gamma Coactivator 1alpha: A Comparative Study.	flavone	21-28	amyloid beta precursor protein	Rattus norvegicus	44-49
25972379-0	2015	Beneficial Effect of Flavone Derivatives on Abeta-Induced Memory Deficit Is Mediated by Peroxisome Proliferator-Activated Receptor gamma Coactivator 1alpha: A Comparative Study.	flavone	21-28	PPARG coactivator 1 alpha	Rattus norvegicus	88-155
25799281-0	2015	Flavone derivatives as inhibitors of insulin amyloid-like fibril formation.	flavone	0-7	insulin	Homo sapiens	37-44
25799281-5	2015	We studied the effects of 265 commercially available flavone derivatives on insulin fibril formation.	flavone	53-60	insulin	Homo sapiens	76-83
25388478-4	2015	Apigenin, wogonin, flavone, 3-hydroxyflavone, 5-hydroxyflavone, 6-hydroxyflavone, and 7-hydroxyflavone effectively inhibited PKM2, with IC50 in the range of 0.99-2.120 muM.	flavone	19-26	pyruvate kinase M1/2	Homo sapiens	125-129
25332053-5	2015	The docking results revealed that amentoflavone (3) showed good interactions with the PAFR model where the flavone and phenolic moieties were mostly involved in these interactions.	flavone	40-47	platelet activating factor receptor	Homo sapiens	86-90
25680459-0	2015	Flavone inhibits nitric oxide synthase (NOS) activity, nitric oxide production and protein S-nitrosylation in breast cancer cells.	flavone	0-7	nitric oxide synthase 2	Homo sapiens	17-38
25388478-8	2015	These results demonstrate that flavone and their analogs could serve as leading compounds to develop new potent and selective inhibitor and activator for PKM2.	flavone	31-38	pyruvate kinase M1/2	Homo sapiens	154-158
25190466-5	2014	Methylated flavone, chrysoeriol (luteolin-3"-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions.	flavone	11-18	matrix metallopeptidase 9	Homo sapiens	104-109
25190466-5	2014	Methylated flavone, chrysoeriol (luteolin-3"-methylether), was found to be the most potent inhibitor of MMP-9 and COX-2 expressions.	flavone	11-18	prostaglandin-endoperoxide synthase 2	Homo sapiens	114-119
25522535-6	2014	Treatment of HepG2 cells with flavone for 24 h reduced the accumulation of intracellular ROS, which correlated with upregulation of Gred, CuZnSOD and MnSOD mRNA levels.	flavone	30-37	superoxide dismutase 2	Homo sapiens	150-155
25122760-2	2014	As an intervention with ER stress responses in the intestinal cancer cells, preventive exposure to flavone apigenin potentiated superinduction of a regulatory transcription factor, activating transcription factor 3 (ATF3), which is also known to be an integral player coordinating ER stress response-related gene expression.	flavone	99-106	activating transcription factor 3	Homo sapiens	181-214
25122760-2	2014	As an intervention with ER stress responses in the intestinal cancer cells, preventive exposure to flavone apigenin potentiated superinduction of a regulatory transcription factor, activating transcription factor 3 (ATF3), which is also known to be an integral player coordinating ER stress response-related gene expression.	flavone	99-106	activating transcription factor 3	Homo sapiens	216-220
28962277-3	2014	Plant flavonoids, such as flavonol quercetin and flavone luteolin, have been suggested to be potential antidepressant compounds because they exert a suppressive effect on the MAO-A reaction.	flavone	49-56	monoamine oxidase A	Homo sapiens	175-180
26839798-0	2015	Design, Synthesis, and Biological Evaluation of New 2-Phenyl-4H-chromen-4-one Derivatives as Selective Cyclooxygenase-2 Inhibitors.	flavone	52-77	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-119
26839798-1	2015	In order to develop new selective COX-2 inhibitors, a new series of 2-phenyl-4H-chromen-4-one derivatives possessing a methylsulfonyl pharmacophore group at the para position of the C-4 phenyl ring were designed, synthesized, and evaluated for cyclooxygenase-2 inhibitory activity.	flavone	68-93	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
26839798-1	2015	In order to develop new selective COX-2 inhibitors, a new series of 2-phenyl-4H-chromen-4-one derivatives possessing a methylsulfonyl pharmacophore group at the para position of the C-4 phenyl ring were designed, synthesized, and evaluated for cyclooxygenase-2 inhibitory activity.	flavone	68-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	244-260
25058688-7	2014	Based on glycophorin A expression, the potency of the other flavonoids for induction of differentiation, was: apigenin&gt;chrysin&gt;flavone/7-hydroxyflavone&gt;luteolin/naringenin.	flavone	133-140	glycophorin A (MNS blood group)	Homo sapiens	9-22
24626522-5	2014	This flavone also suppressed the expression of both cyclin B1 and its activating partners, Cdc2 and Cdc25c, whereas the expression of cell cycle inhibitors, such as p53 and p53-dependent p21(CIP1/WAF1), was increased after apigenin treatment.	flavone	5-12	cyclin B1	Homo sapiens	52-61
24280938-3	2014	We hypothesized that targeting the intracellular protein myeloid cell leukemia 1 (Mcl-1) by a cyclin-dependent kinase inhibitor (AT7519) or a flavone (wogonin) would accelerate neutrophil apoptosis and resolution of established inflammation, but without detriment to bacterial clearance.	flavone	142-149	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	57-80
24510324-0	2014	Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells.	flavone	25-32	protein tyrosine kinase 2	Homo sapiens	92-95
24510324-0	2014	Antitumor effects of the flavone chalcone: inhibition of invasion and migration through the FAK/JNK signaling pathway in human gastric adenocarcinoma AGS cells.	flavone	25-32	mitogen-activated protein kinase 8	Homo sapiens	96-99
24905290-0	2014	Binding of antioxidant flavone isovitexin to human serum albumin investigated by experimental and computational assays.	flavone	23-30	albumin	Homo sapiens	51-64
24780403-6	2014	The relationship between chalcone, flavanones and flavone structures interpreted by docking studies on cathepsin B and H also provided useful insights.	flavone	50-57	cathepsin B	Homo sapiens	103-114
24626522-5	2014	This flavone also suppressed the expression of both cyclin B1 and its activating partners, Cdc2 and Cdc25c, whereas the expression of cell cycle inhibitors, such as p53 and p53-dependent p21(CIP1/WAF1), was increased after apigenin treatment.	flavone	5-12	cyclin dependent kinase 1	Homo sapiens	91-95
24626522-5	2014	This flavone also suppressed the expression of both cyclin B1 and its activating partners, Cdc2 and Cdc25c, whereas the expression of cell cycle inhibitors, such as p53 and p53-dependent p21(CIP1/WAF1), was increased after apigenin treatment.	flavone	5-12	cell division cycle 25C	Homo sapiens	100-106
24626522-5	2014	This flavone also suppressed the expression of both cyclin B1 and its activating partners, Cdc2 and Cdc25c, whereas the expression of cell cycle inhibitors, such as p53 and p53-dependent p21(CIP1/WAF1), was increased after apigenin treatment.	flavone	5-12	tumor protein p53	Homo sapiens	173-176
24626522-5	2014	This flavone also suppressed the expression of both cyclin B1 and its activating partners, Cdc2 and Cdc25c, whereas the expression of cell cycle inhibitors, such as p53 and p53-dependent p21(CIP1/WAF1), was increased after apigenin treatment.	flavone	5-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	187-190
24626522-5	2014	This flavone also suppressed the expression of both cyclin B1 and its activating partners, Cdc2 and Cdc25c, whereas the expression of cell cycle inhibitors, such as p53 and p53-dependent p21(CIP1/WAF1), was increased after apigenin treatment.	flavone	5-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	191-195
24626522-5	2014	This flavone also suppressed the expression of both cyclin B1 and its activating partners, Cdc2 and Cdc25c, whereas the expression of cell cycle inhibitors, such as p53 and p53-dependent p21(CIP1/WAF1), was increased after apigenin treatment.	flavone	5-12	cyclin dependent kinase inhibitor 1A	Homo sapiens	196-200
24333230-3	2014	In this study, the inhibitory activity of flavone luteolin on alpha-glucosidase and their interaction mechanism were investigated by multispectroscopic methods along with molecular docking technique.	flavone	42-49	sucrase-isomaltase	Homo sapiens	62-79
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
24336456-6	2014	Higher anthocyanin intake was also associated with lower hs-CRP concentrations (Q5-Q1 = -0.3 mg/L, P-trend = 0.04), whereas those in the highest quintile of flavone intake had improved adiponectin concentrations (Q5-Q1 = 0.7 mug/L, P-trend = 0.01).	flavone	157-164	adiponectin, C1Q and collagen domain containing	Homo sapiens	185-196
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	interleukin 6	Homo sapiens	74-78
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	C-C motif chemokine ligand 2	Homo sapiens	80-116
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	C-C motif chemokine ligand 2	Homo sapiens	118-123
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	130-146
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-153
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	nuclear factor kappa B subunit 1	Homo sapiens	187-213
24134915-2	2013	Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta.	flavone	0-7	interleukin 1 beta	Homo sapiens	293-315
24060488-0	2013	Flavone-based analogues inspired by the natural product simocyclinone D8 as DNA gyrase inhibitors.	flavone	0-7	DNA topoisomerase II alpha	Homo sapiens	76-86
23958298-9	2013	Flavone, which does not contain any methoxy groups, also suppressed iNOS induction.	flavone	0-7	nitric oxide synthase 2	Rattus norvegicus	68-72
29364964-0	2013	Correction: Properties and Molecular Determinants of the Natural Flavone Acacetin for Blocking hKv4.3 Channels.	flavone	65-72	potassium voltage-gated channel subfamily D member 3	Homo sapiens	95-101
23782265-3	2013	To this end we carried out a screen of 1031 existing medicinal compounds to identify inducers of SOCS3 gene expression and identified the flavanoids naringenin and flavone as effective inducers of SOCS3 protein, mRNA and promoter activity.	flavone	164-171	suppressor of cytokine signaling 3	Homo sapiens	197-202
23861346-9	2013	Furthermore, we identified that apigenin, a natural product of the flavone family, inhibits ABCB1 expression and resensitizes docetaxel-resistant prostate cancer cells to docetaxel treatment.	flavone	67-74	ATP binding cassette subfamily B member 1	Homo sapiens	92-97
23782265-5	2013	Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent.	flavone	20-27	interleukin 6	Homo sapiens	56-60
23782265-5	2013	Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent.	flavone	20-27	signal transducer and activator of transcription 3	Homo sapiens	91-96
23782265-5	2013	Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent.	flavone	20-27	interleukin 6	Homo sapiens	134-138
23782265-5	2013	Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent.	flavone	20-27	signal transducer and activator of transcription 3	Homo sapiens	168-173
23782265-5	2013	Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent.	flavone	20-27	C-C motif chemokine ligand 2	Homo sapiens	186-190
23782265-5	2013	Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent.	flavone	20-27	C-C motif chemokine ligand 2	Homo sapiens	192-222
23782265-5	2013	Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent.	flavone	20-27	suppressor of cytokine signaling 3	Homo sapiens	265-270
23782265-5	2013	Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent.	flavone	20-27	signal transducer and activator of transcription 3	Homo sapiens	168-173
23790540-0	2013	Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL.	flavone	26-33	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	84-87
23790540-2	2013	Here, we report a series of flavone-based common inhibitors equipotent for the wild type and the most drug-resistant T315I mutant of BCR-ABL.	flavone	28-35	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	133-140
23402418-0	2013	Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells.	flavone	103-110	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	25-57
23639191-14	2013	CONCLUSION: We provided documentation of neuroprotective effect of a natural flavone, calycopterin, against H2O2-induced oxidative stress in differentiated PC12 cells by modulating the level of CREB phosphorylation and Nrf2 pathway.	flavone	77-84	cAMP responsive element binding protein 1	Rattus norvegicus	194-198
23639191-14	2013	CONCLUSION: We provided documentation of neuroprotective effect of a natural flavone, calycopterin, against H2O2-induced oxidative stress in differentiated PC12 cells by modulating the level of CREB phosphorylation and Nrf2 pathway.	flavone	77-84	NFE2 like bZIP transcription factor 2	Rattus norvegicus	219-223
23481040-3	2013	Herein, the effects and mechanisms of the novel flavone 3,3"-diamino-4"-methoxyflavone (DD1) on AML cell dysfunction were investigated in AML cells (monoblast U937, myelomonocyte OCI-AML3, promyelocyte NB4, myeloblast HL-60) and blood samples from patients with AML.	flavone	48-55	aldo-keto reductase family 1 member C1	Homo sapiens	88-91
23481040-5	2013	The flavone"s apoptotic action in U937 cells was associated with recruitment of mitochondria, Bax activation, Bad dephosphorylation (at Ser(136)), activation of caspases -8, -9, and -3 and cleavage of the caspase substrate PARP-1.	flavone	4-11	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97
23481040-5	2013	The flavone"s apoptotic action in U937 cells was associated with recruitment of mitochondria, Bax activation, Bad dephosphorylation (at Ser(136)), activation of caspases -8, -9, and -3 and cleavage of the caspase substrate PARP-1.	flavone	4-11	caspase 8	Homo sapiens	161-184
23481040-5	2013	The flavone"s apoptotic action in U937 cells was associated with recruitment of mitochondria, Bax activation, Bad dephosphorylation (at Ser(136)), activation of caspases -8, -9, and -3 and cleavage of the caspase substrate PARP-1.	flavone	4-11	poly(ADP-ribose) polymerase 1	Homo sapiens	223-229
23574272-2	2013	Flavone has been previously identified as a tankyrase inhibitor, and to further elucidate whether tankyrases would be inhibited by other flavonoids, we performed a systematic screening of tankyrase 2 inhibitory activity using 500 natural and naturally derived flavonoids covering nine different flavonoid classes.	flavone	0-7	tankyrase	Homo sapiens	44-53
23574272-2	2013	Flavone has been previously identified as a tankyrase inhibitor, and to further elucidate whether tankyrases would be inhibited by other flavonoids, we performed a systematic screening of tankyrase 2 inhibitory activity using 500 natural and naturally derived flavonoids covering nine different flavonoid classes.	flavone	0-7	tankyrase 2	Homo sapiens	188-199
23574272-5	2013	Flavone derivatives in all 10 crystal structures bind to the nicotinamide binding site of tankyrase 2.	flavone	0-7	tankyrase 2	Homo sapiens	90-101
23402418-0	2013	Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells.	flavone	103-110	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	59-63
23402418-0	2013	Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells.	flavone	103-110	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	129-135
23104169-0	2013	Influence of glucose on the human serum albumin-flavone interaction and their antioxidant activity.	flavone	48-55	albumin	Homo sapiens	34-47
23195034-7	2013	Flavone-induced apoptosis was preceded by down-regulation of the prosurvival protein Mcl-1, with proteasomal inhibition preventing flavone-induced Mcl-1 down-regulation and apoptosis.	flavone	0-7	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	85-90
23195034-7	2013	Flavone-induced apoptosis was preceded by down-regulation of the prosurvival protein Mcl-1, with proteasomal inhibition preventing flavone-induced Mcl-1 down-regulation and apoptosis.	flavone	0-7	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	147-152
23195034-7	2013	Flavone-induced apoptosis was preceded by down-regulation of the prosurvival protein Mcl-1, with proteasomal inhibition preventing flavone-induced Mcl-1 down-regulation and apoptosis.	flavone	131-138	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	85-90
23195034-7	2013	Flavone-induced apoptosis was preceded by down-regulation of the prosurvival protein Mcl-1, with proteasomal inhibition preventing flavone-induced Mcl-1 down-regulation and apoptosis.	flavone	131-138	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	147-152
23035634-0	2013	Effects of flavone derivatives on antigen-stimulated degranulation in RBL-2H3 cells.	flavone	11-18	RB transcriptional corepressor like 2	Rattus norvegicus	70-75
23362992-1	2013	Flavone glucuronide isomers of five flavones (chrysin, apigenin, luteolin, baicalein, and scutellarein) were differentiated by collision-induced dissociation of [Co(II) (flavone-H) (4,7-diphenyl-1,10-phenanthroline)(2)](+) complexes.	flavone	0-7	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-168
22957647-5	2012	In human prostate cancer DU145 cells with mutated RB, flavone increased cyclin-dependent kinase (CDK) inhibitors p21 and p27, and reduced cdk4 and cdk6, resulting in decrement of phosphorylated RB family proteins p130 and p107.	flavone	54-61	H3 histone pseudogene 16	Homo sapiens	113-116
23526953-0	2013	Properties and molecular determinants of the natural flavone acacetin for blocking hKv4.3 channels.	flavone	53-60	potassium voltage-gated channel subfamily D member 3	Homo sapiens	83-89
22850197-5	2012	These findings, together with the data from peptide mass fingerprints, indicate that FLN-270 and FLN-230 are different isoforms of mussel filamin, with FLN-230 being the predominant isoform in the mussel catch muscle.	flavone	85-88	filamin C	Homo sapiens	138-145
23127826-0	2013	Structure-based design of flavone derivatives as c-myc oncogene down-regulators.	flavone	26-33	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	49-54
23127826-1	2013	Based on molecular docking analysis of complexes between flavone and the c-myc G-quadruplex, we designed and screened 30 flavone derivatives containing various side chains that could potentially form interactions with the G-quadruplex grooves.	flavone	57-64	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	73-78
23127826-1	2013	Based on molecular docking analysis of complexes between flavone and the c-myc G-quadruplex, we designed and screened 30 flavone derivatives containing various side chains that could potentially form interactions with the G-quadruplex grooves.	flavone	121-128	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	73-78
23127826-2	2013	As a proof-of-concept, the highest-scoring flavone derivatives containing cationic pyridinium side chains were synthesized and their interactions with the c-myc G-quadruplex were examined using a PCR-stop assay.	flavone	43-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	155-160
23127826-3	2013	The stabilizing effects of the flavone derivatives were found to be selective towards the c-myc G-quadruplex over other biologically relevant G-quadruplex structures, such as the human telomeric sequence (HTS).	flavone	31-38	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	90-95
23127826-5	2013	Our results suggest that in addition to stabilizing the c-myc G-quadruplex, the flavone derivatives were capable of inducing the formation of the G-quadruplex structure even in the absence of monovalent cations.	flavone	80-87	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	56-61
23127826-6	2013	The flavone derivatives were found to be potent inhibitors of c-myc promoters within the cellular environment and displayed promising cytotoxic behavior against human cancer cell lines.	flavone	4-11	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	62-67
23063682-12	2012	In conclusion, our data shows that certain phytochemicals with 2-phenyl-1-benzopyran-4-one backbone (flavones) attenuate significantly the IDO-1 protein activity without harming hNSCs.	flavone	63-90	indoleamine 2,3-dioxygenase 1	Homo sapiens	139-144
22965624-0	2012	Flavone reduces the production of virulence factors, staphyloxanthin and alpha-hemolysin, in Staphylococcus aureus.	flavone	0-7	AT695_RS11870	Staphylococcus aureus	73-88
22965624-4	2012	Flavone, a backbone compound of flavonoids, at subinhibitory concentration (50 mug/mL), markedly reduced the production of staphyloxanthin and alpha-hemolysin.	flavone	0-7	AT695_RS11870	Staphylococcus aureus	143-158
22965624-6	2012	In addition, flavone significantly decreased the hemolysis of human red blood by S. aureus, and the transcriptional level of alpha-hemolysin gene hla and a global regulator gene sae in S. aureus cells.	flavone	13-20	AT695_RS11870	Staphylococcus aureus	125-140
22957647-5	2012	In human prostate cancer DU145 cells with mutated RB, flavone increased cyclin-dependent kinase (CDK) inhibitors p21 and p27, and reduced cdk4 and cdk6, resulting in decrement of phosphorylated RB family proteins p130 and p107.	flavone	54-61	interferon alpha inducible protein 27	Homo sapiens	121-124
22957647-5	2012	In human prostate cancer DU145 cells with mutated RB, flavone increased cyclin-dependent kinase (CDK) inhibitors p21 and p27, and reduced cdk4 and cdk6, resulting in decrement of phosphorylated RB family proteins p130 and p107.	flavone	54-61	cyclin dependent kinase 4	Homo sapiens	138-142
22957647-5	2012	In human prostate cancer DU145 cells with mutated RB, flavone increased cyclin-dependent kinase (CDK) inhibitors p21 and p27, and reduced cdk4 and cdk6, resulting in decrement of phosphorylated RB family proteins p130 and p107.	flavone	54-61	cyclin dependent kinase 6	Homo sapiens	147-151
22957647-5	2012	In human prostate cancer DU145 cells with mutated RB, flavone increased cyclin-dependent kinase (CDK) inhibitors p21 and p27, and reduced cdk4 and cdk6, resulting in decrement of phosphorylated RB family proteins p130 and p107.	flavone	54-61	RB transcriptional corepressor like 2	Homo sapiens	213-217
22957647-5	2012	In human prostate cancer DU145 cells with mutated RB, flavone increased cyclin-dependent kinase (CDK) inhibitors p21 and p27, and reduced cdk4 and cdk6, resulting in decrement of phosphorylated RB family proteins p130 and p107.	flavone	54-61	RB transcriptional corepressor like 1	Homo sapiens	222-226
22957647-8	2012	These results suggested that p130 and p107 contributed to G(1)  phase arrest by flavone in RB-mutated cells.	flavone	80-87	RB transcriptional corepressor like 2	Homo sapiens	29-33
22957647-8	2012	These results suggested that p130 and p107 contributed to G(1)  phase arrest by flavone in RB-mutated cells.	flavone	80-87	RB transcriptional corepressor like 1	Homo sapiens	38-42
22957647-9	2012	However, flavone induced tumor suppressor microRNA miR-34a with reduction of E2F1 and E2F3, known to be downregulated by miR-34a, raising the possibility that miR-34a might partially contribute to G(1)  arrest by flavone.	flavone	9-16	microRNA 34a	Homo sapiens	51-58
22957647-9	2012	However, flavone induced tumor suppressor microRNA miR-34a with reduction of E2F1 and E2F3, known to be downregulated by miR-34a, raising the possibility that miR-34a might partially contribute to G(1)  arrest by flavone.	flavone	9-16	E2F transcription factor 1	Homo sapiens	77-81
22957647-9	2012	However, flavone induced tumor suppressor microRNA miR-34a with reduction of E2F1 and E2F3, known to be downregulated by miR-34a, raising the possibility that miR-34a might partially contribute to G(1)  arrest by flavone.	flavone	9-16	E2F transcription factor 3	Homo sapiens	86-90
22957647-9	2012	However, flavone induced tumor suppressor microRNA miR-34a with reduction of E2F1 and E2F3, known to be downregulated by miR-34a, raising the possibility that miR-34a might partially contribute to G(1)  arrest by flavone.	flavone	9-16	microRNA 34a	Homo sapiens	121-128
22957647-9	2012	However, flavone induced tumor suppressor microRNA miR-34a with reduction of E2F1 and E2F3, known to be downregulated by miR-34a, raising the possibility that miR-34a might partially contribute to G(1)  arrest by flavone.	flavone	9-16	microRNA 34a	Homo sapiens	121-128
23221529-7	2012	Western blot analysis suggested that the flavone substantially increased the levels of the death receptor-associated apoptosis mediators Fas, Fas L, FADD, TRADD, and DR4 in a concentration-dependent manner.	flavone	41-48	Fas ligand	Homo sapiens	142-147
23221529-7	2012	Western blot analysis suggested that the flavone substantially increased the levels of the death receptor-associated apoptosis mediators Fas, Fas L, FADD, TRADD, and DR4 in a concentration-dependent manner.	flavone	41-48	Fas associated via death domain	Homo sapiens	149-153
23221529-7	2012	Western blot analysis suggested that the flavone substantially increased the levels of the death receptor-associated apoptosis mediators Fas, Fas L, FADD, TRADD, and DR4 in a concentration-dependent manner.	flavone	41-48	TNFRSF1A associated via death domain	Homo sapiens	155-160
23221529-7	2012	Western blot analysis suggested that the flavone substantially increased the levels of the death receptor-associated apoptosis mediators Fas, Fas L, FADD, TRADD, and DR4 in a concentration-dependent manner.	flavone	41-48	major histocompatibility complex, class II, DR beta 4	Homo sapiens	166-169
22965487-2	2012	METHODS AND RESULTS: Rhodamine absorption displayed saturation kinetics with a K(m)  of 1.1 muM and a pH-optimum of 8.5 and was stimulated by flavone four-fold in its V(max) .	flavone	142-149	latexin	Homo sapiens	92-95
22006862-0	2012	Plant flavone apigenin inhibits HDAC and remodels chromatin to induce growth arrest and apoptosis in human prostate cancer cells: in vitro and in vivo study.	flavone	6-13	histone deacetylase 9	Homo sapiens	32-36
23200064-10	2012	We recently found that certain flavone molecules profoundly inhibit the enzymatic activity of IDO-1 but not mRNA expression in human neuronal stem cells (hNSC) confirmed by cell-based assay and qRT-PCR.	flavone	31-38	indoleamine 2,3-dioxygenase 1	Homo sapiens	94-99
23256366-1	2012	OBJECTIVE: To evaluate influence of assemble flavone of rhizome drynaria (AFDR) on the value of the blood serum alkalinity phosphatase (ALP), calcium (Ca), phosphorus (P), creatinine (Cr) and glutamic-pyruvic transaminase (GPT) in rats model with skull defects.	flavone	45-52	glutamic--pyruvic transaminase	Rattus norvegicus	192-221
22634477-5	2012	In MCF-7 breast carcinoma cells chalcone and flavone suppress ERalpha activity through stimulation of the stress-activated members of the mitogen-activated protein kinase (MAPK) family: c-Jun N-terminal kinase (JNK)1 and JNK2.	flavone	45-52	estrogen receptor 1	Homo sapiens	62-69
22634477-5	2012	In MCF-7 breast carcinoma cells chalcone and flavone suppress ERalpha activity through stimulation of the stress-activated members of the mitogen-activated protein kinase (MAPK) family: c-Jun N-terminal kinase (JNK)1 and JNK2.	flavone	45-52	mitogen-activated protein kinase 8	Homo sapiens	186-216
22634477-5	2012	In MCF-7 breast carcinoma cells chalcone and flavone suppress ERalpha activity through stimulation of the stress-activated members of the mitogen-activated protein kinase (MAPK) family: c-Jun N-terminal kinase (JNK)1 and JNK2.	flavone	45-52	mitogen-activated protein kinase 9	Homo sapiens	221-225
22634477-6	2012	The use of dominant-negative mutants of JNK1 or JNK2 in stable transfected cells established that the antiestrogenic effects of chalcone and flavone required intact JNK signaling.	flavone	141-148	mitogen-activated protein kinase 8	Homo sapiens	40-44
22634477-6	2012	The use of dominant-negative mutants of JNK1 or JNK2 in stable transfected cells established that the antiestrogenic effects of chalcone and flavone required intact JNK signaling.	flavone	141-148	mitogen-activated protein kinase 8	Homo sapiens	40-43
22743247-6	2012	The intracellular CYP1-mediated bioconversion of the flavone was reduced in the presence of the CYP1A1 and CYP1B1-selective inhibitors alpha-napthoflavone and acacetin.	flavone	53-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	18-22
22743247-6	2012	The intracellular CYP1-mediated bioconversion of the flavone was reduced in the presence of the CYP1A1 and CYP1B1-selective inhibitors alpha-napthoflavone and acacetin.	flavone	53-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	96-102
22743247-6	2012	The intracellular CYP1-mediated bioconversion of the flavone was reduced in the presence of the CYP1A1 and CYP1B1-selective inhibitors alpha-napthoflavone and acacetin.	flavone	53-60	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	107-113
22825681-0	2012	Pollen Typhae total flavone improves insulin-induced glucose uptake             through the beta-arrestin-2-mediated signaling in C2C12 myotubes.	flavone	20-27	arrestin beta 2	Homo sapiens	92-107
23256366-1	2012	OBJECTIVE: To evaluate influence of assemble flavone of rhizome drynaria (AFDR) on the value of the blood serum alkalinity phosphatase (ALP), calcium (Ca), phosphorus (P), creatinine (Cr) and glutamic-pyruvic transaminase (GPT) in rats model with skull defects.	flavone	45-52	glutamic--pyruvic transaminase	Rattus norvegicus	223-226
22559745-6	2012	Moreover, sonicated mitochondria also augmented VEGF release, and this effect was blocked by the natural flavone luteolin.	flavone	105-112	vascular endothelial growth factor A	Homo sapiens	48-52
22357873-10	2012	A flavone derivative, apigenin, and isopropyl gallate showed potency on the micromolar range, but displayed over 30-fold selectivity for tankyrase over the studied isoenzymes PARP1 and PARP2.	flavone	2-9	tankyrase	Homo sapiens	137-146
22357873-10	2012	A flavone derivative, apigenin, and isopropyl gallate showed potency on the micromolar range, but displayed over 30-fold selectivity for tankyrase over the studied isoenzymes PARP1 and PARP2.	flavone	2-9	poly(ADP-ribose) polymerase 1	Homo sapiens	175-180
22357873-10	2012	A flavone derivative, apigenin, and isopropyl gallate showed potency on the micromolar range, but displayed over 30-fold selectivity for tankyrase over the studied isoenzymes PARP1 and PARP2.	flavone	2-9	poly(ADP-ribose) polymerase 2	Homo sapiens	185-190
22172629-10	2012	Treating cells with PD98059 (a flavone-type MEK1 inhibitor) increased CYP11B1 promoter activity, but not involving ERK signaling because phosphorylation of ERK1/2 remained unvarying throughout the course of treatment.	flavone	31-38	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	70-77
22049911-0	2012	Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel.	flavone	26-33	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	45-85
22128188-7	2012	Redirection of this reductant flux exclusively through the proton-coupled NDH-1 by inhibition of NDH-2 with flavone increases the photo-H(2) production rate by 2-fold (at the expense of the dark-H(2) rate), due to production of additional ATP (via the proton gradient).	flavone	108-115	DExH-box helicase 9	Homo sapiens	97-102
22172629-7	2012	The Ad5 element situated in the -121/-106 region was required for basal and flavone-induced CYP11B1 expression.	flavone	76-83	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	92-99
22172629-10	2012	Treating cells with PD98059 (a flavone-type MEK1 inhibitor) increased CYP11B1 promoter activity, but not involving ERK signaling because phosphorylation of ERK1/2 remained unvarying throughout the course of treatment.	flavone	31-38	mitogen-activated protein kinase kinase 1	Homo sapiens	44-48
22768128-3	2012	Here we report the differential cytotoxic effects of two flavone isomers on human cancer cells from breast (MCF7, SK-BR-3), colon (Caco-2, HCT116), pancreas (MIA PaCa, Panc 28), and prostate (PC3, LNCaP) that vary in differentiation status and tumorigenic potential.	flavone	57-64	chromobox 8	Homo sapiens	192-195
22946894-3	2012	Further, the role of proinflammatory cytokines like TNF-alpha and IL-1beta, cyclooxygenases (COX-1 and COX-2), and free radicals in the action of flavone derivatives was investigated using in vitro assays.	flavone	146-153	tumor necrosis factor	Rattus norvegicus	52-61
22946894-3	2012	Further, the role of proinflammatory cytokines like TNF-alpha and IL-1beta, cyclooxygenases (COX-1 and COX-2), and free radicals in the action of flavone derivatives was investigated using in vitro assays.	flavone	146-153	interleukin 1 beta	Rattus norvegicus	66-74
22946894-3	2012	Further, the role of proinflammatory cytokines like TNF-alpha and IL-1beta, cyclooxygenases (COX-1 and COX-2), and free radicals in the action of flavone derivatives was investigated using in vitro assays.	flavone	146-153	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	93-98
22946894-3	2012	Further, the role of proinflammatory cytokines like TNF-alpha and IL-1beta, cyclooxygenases (COX-1 and COX-2), and free radicals in the action of flavone derivatives was investigated using in vitro assays.	flavone	146-153	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	103-108
21899256-3	2011	Here we analyzed the interaction of GLUT1 with quercetin (a flavone), genistein (an isoflavone), and tyrphostin A47 and B46 to evaluate if they share one common or have several binding sites on the protein.	flavone	60-67	solute carrier family 2 member 1	Homo sapiens	36-41
22220313-13	2004	first synthesized a class of radioiodinated flavone derivatives that present a high binding affinity with Abeta plaques and good penetration ability through the BBB (5).	flavone	44-51	amyloid beta precursor protein	Homo sapiens	106-111
22220317-13	2004	first synthesized a class of radioiodinated flavone derivatives that present a high binding affinity with Abeta plaques and good penetration ability through the BBB (5).	flavone	44-51	amyloid beta precursor protein	Homo sapiens	106-111
22220319-14	2004	first synthesized a class of radioiodinated flavone derivatives that present a high binding affinity with Abeta plaques and good penetration ability through the BBB (5).	flavone	44-51	amyloid beta precursor protein	Homo sapiens	106-111
22220320-13	2004	first synthesized a class of radioiodinated flavone derivatives that present a high binding affinity with Abeta plaques and good penetration ability through the BBB (5).	flavone	44-51	amyloid beta precursor protein	Homo sapiens	106-111
21341175-5	2011	Four flavonoids (flavone, isorhamnetin, daidzein, and genistein) inhibited significantly LPS-induced COX-2 expression, while mPGES-1 expression was downregulated by kaempferol and isorhamnetin.	flavone	17-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
21907578-1	2011	It has been previously shown that some flavonoids inhibit NF-kappaB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFalpha induced NF-kappaB inhibitory effects on HCT116 human colon cancer cells have not yet been reported.	flavone	144-151	nuclear factor kappa B subunit 1	Homo sapiens	58-67
21907578-1	2011	It has been previously shown that some flavonoids inhibit NF-kappaB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFalpha induced NF-kappaB inhibitory effects on HCT116 human colon cancer cells have not yet been reported.	flavone	144-151	tumor necrosis factor	Homo sapiens	190-198
21907578-1	2011	It has been previously shown that some flavonoids inhibit NF-kappaB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFalpha induced NF-kappaB inhibitory effects on HCT116 human colon cancer cells have not yet been reported.	flavone	144-151	nuclear factor kappa B subunit 1	Homo sapiens	207-216
21554863-10	2011	Results of the present investigation provide evidence that attenuation of Wnt pathway and suppression of inflammatory response mediated by NF-kB could be implicated, in part, in the chemopreventive effects of methylated flavone.	flavone	220-227	Wnt family member 2	Rattus norvegicus	74-77
21554863-10	2011	Results of the present investigation provide evidence that attenuation of Wnt pathway and suppression of inflammatory response mediated by NF-kB could be implicated, in part, in the chemopreventive effects of methylated flavone.	flavone	220-227	nuclear factor kappa B subunit 1	Rattus norvegicus	139-144
21625621-8	2011	Both fln and to mutations caused complete loss of CerS1 catalytic activity, which resulted in a reduction in sphingolipid biosynthesis in the brain and dramatic changes in steady-state levels of sphingolipids and sphingoid bases.	flavone	5-8	ceramide synthase 1	Mus musculus	50-55
21776020-6	2011	We show that genetic inhibition of Mcl-1 or CDK9 expression by siRNA is sufficient to mimic flavone-induced apoptosis.	flavone	92-99	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	35-40
21776020-6	2011	We show that genetic inhibition of Mcl-1 or CDK9 expression by siRNA is sufficient to mimic flavone-induced apoptosis.	flavone	92-99	cyclin dependent kinase 9	Homo sapiens	44-48
21482471-5	2011	The most potent inhibitors of CYP1-EROD activity were the methoxylated flavones acacetin, diosmetin, eupatorin and the di-hydroxylated flavone chrysin, indicating that the 4"-OCH(3) group at the B ring and the 5,7-dihydroxy motif at the A ring play a prominent role in EROD inhibition.	flavone	71-78	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	30-34
21482471-7	2011	HPLC metabolism of acacetin by CYP1A1 and CYP1B1 revealed the formation of the structurally similar flavone apigenin by demethylation at the 4"-position of the B ring, whereas the flavone eupatorin-5-methyl ether was metabolized to an as yet unidentified metabolite assigned E(5)M1.	flavone	100-107	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	31-37
21482471-7	2011	HPLC metabolism of acacetin by CYP1A1 and CYP1B1 revealed the formation of the structurally similar flavone apigenin by demethylation at the 4"-position of the B ring, whereas the flavone eupatorin-5-methyl ether was metabolized to an as yet unidentified metabolite assigned E(5)M1.	flavone	100-107	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	42-48
21294849-0	2011	Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK.	flavone	43-50	epidermal growth factor receptor	Homo sapiens	97-101
21294849-0	2011	Synthesis and studies on three-compartment flavone-containing combi-molecules designed to target EGFR, DNA, and MEK.	flavone	43-50	mitogen-activated protein kinase kinase 7	Homo sapiens	112-115
21652696-0	2011	Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.	flavone	12-19	Wnt family member 2	Rattus norvegicus	92-95
21652696-0	2011	Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.	flavone	12-19	catenin beta 1	Rattus norvegicus	96-108
21346142-4	2011	Using this approach, the flavone apigenin was identified as an inhibitor of MUC1-CD dimerization in vitro and in cells.	flavone	25-32	mucin 1, cell surface associated	Homo sapiens	76-80
20878474-10	2011	The hydroxylation on position 3" of flavone slightly improves the binding affinity for HSA.	flavone	36-43	albumin	Homo sapiens	87-90