PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2543690-7	1989	In keeping with her clinical picture, basal (24-h samples drawn every 60 min) and ovine CRH-stimulated plasma adrenal androgen (dehydroepiandrosterone sulfate and delta 4-androstenedione) concentrations and 24-h urinary 17-ketosteroid excretion were low on both the day on and the day off prednisone.	Dehydroepiandrosterone Sulfate	128-158	corticotropin releasing hormone	Homo sapiens	88-91
2560404-3	1989	However, the effects of PM differed from those of EGF and FGF in several respects: 1) maximal response to PM was 2-5 times greater; 2) mitogenic effects of EGF and FGF were suppressed by adrenocorticotropic hormone (ACTH), whereas that of 50% PM was not; 3) PM inhibited ACTH-stimulated steroidogenesis (dehydroepiandrosterone sulfate and cortisol), but EGF and FGF did not.	Dehydroepiandrosterone Sulfate	304-334	epidermal growth factor	Homo sapiens	156-159
2560404-3	1989	However, the effects of PM differed from those of EGF and FGF in several respects: 1) maximal response to PM was 2-5 times greater; 2) mitogenic effects of EGF and FGF were suppressed by adrenocorticotropic hormone (ACTH), whereas that of 50% PM was not; 3) PM inhibited ACTH-stimulated steroidogenesis (dehydroepiandrosterone sulfate and cortisol), but EGF and FGF did not.	Dehydroepiandrosterone Sulfate	304-334	epidermal growth factor	Homo sapiens	156-159
2529264-0	1989	Suppression of serum dehydroepiandrosterone sulfate levels by insulin: an evaluation of possible mechanisms.	Dehydroepiandrosterone Sulfate	21-51	insulin	Homo sapiens	62-69
2529264-2	1989	To determine whether this fall in serum DHEA-S levels might have been due to insulin-stimulated 1) hydrolysis of DHEA-S to dehydroepiandrosterone (DHEA), 2) conversion of DHEA-S/DHEA to androstenedione, and/or 3) urinary excretion of these steroids, 10 additional men were studied by the hyperinsulinemic-euglycemic clamp technique.	Dehydroepiandrosterone Sulfate	40-46	insulin	Homo sapiens	77-84
2529264-2	1989	To determine whether this fall in serum DHEA-S levels might have been due to insulin-stimulated 1) hydrolysis of DHEA-S to dehydroepiandrosterone (DHEA), 2) conversion of DHEA-S/DHEA to androstenedione, and/or 3) urinary excretion of these steroids, 10 additional men were studied by the hyperinsulinemic-euglycemic clamp technique.	Dehydroepiandrosterone Sulfate	113-119	insulin	Homo sapiens	77-84
2529264-2	1989	To determine whether this fall in serum DHEA-S levels might have been due to insulin-stimulated 1) hydrolysis of DHEA-S to dehydroepiandrosterone (DHEA), 2) conversion of DHEA-S/DHEA to androstenedione, and/or 3) urinary excretion of these steroids, 10 additional men were studied by the hyperinsulinemic-euglycemic clamp technique.	Dehydroepiandrosterone Sulfate	113-119	insulin	Homo sapiens	77-84
2554064-3	1989	Enzyme activity was present in 93% of the ER + tumor cytosols (mean 59 +/- 44 (SD) pmol dehydroepiandrosterone sulphate formed per mg protein per 2 h (n = 42).	Dehydroepiandrosterone Sulfate	88-119	estrogen receptor 1	Homo sapiens	42-44
2532426-1	1989	Dehydroepiandrosterone sulfate (DHEAS) and unconjugated dehydroepiandrosterone (DHEA) are secretory products of the adrenal cortex.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
2532427-1	1989	We measured serum dehydroepiandrosterone sulfate (DHEA-S) levels by nine different radioimmunoassay (RIA) methods.	Dehydroepiandrosterone Sulfate	18-48	sulfotransferase family 2A member 1	Homo sapiens	50-56
2783155-8	1989	In the female rat liver which showed the highest 5-HCR-sulphating activity among the examined tissues of all the animals, a typical hydroxysteroid sulphotransferase inhibitor, dehydroepiandrosterone (DHA) sulphate (1 mM), potently and competitively inhibited the sulphation of 5-HCR as well as that of DHA, a typical substrate for hydroxysteroid sulphotransferases.	Dehydroepiandrosterone Sulfate	176-213	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	279-282
2531156-1	1989	We measured dehydroepiandrosterone sulfate (DHEA-S) levels in children before and after high dose prednisone therapy.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-50
2531049-1	1989	Previous reports on patients with endogenous Cushing"s syndrome describe low concentrations of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) in adrenal adenoma and in a case of feminizing macronodular hyperplasia.	Dehydroepiandrosterone Sulfate	116-146	sulfotransferase family 2A member 1	Homo sapiens	148-154
2531771-1	1989	The purpose of the present investigation was to verify possible positive correlations between prolactin secretion and dehydroepiandrosterone sulphate levels in plasma of women with benign breast disease.	Dehydroepiandrosterone Sulfate	118-149	prolactin	Homo sapiens	94-103
2527376-1	1989	We hypothesized that the dehydroepiandrosterone-sulfate (DHEA-S)/cortisol ratio, which has been used as an index of adrenocortical function, would be altered in panic disorder patients and would change after treatment.	Dehydroepiandrosterone Sulfate	25-55	sulfotransferase family 2A member 1	Homo sapiens	57-63
2524947-0	1989	Role of prolactin in age-related change in serum dehydroepiandrosterone sulphate concentrations.	Dehydroepiandrosterone Sulfate	49-80	prolactin	Homo sapiens	8-17
2550341-5	1989	The hypothesis that insulin increases steroid sulfatase activity was examined by exposing cytotrophoblasts to supraphysiological concentrations of either insulin (2 micrograms/ml) or IGF-I (20 ng/ml) for 24 h and then measuring the rate of DHEA-S hydrolysis.	Dehydroepiandrosterone Sulfate	240-246	insulin	Homo sapiens	20-27
2550341-10	1989	These observations suggest that the decline in serum DHEA-S levels during hyperinsulinemia is not mediated via an insulin-induced increase in steroid sulfatase activity.	Dehydroepiandrosterone Sulfate	53-59	insulin	Homo sapiens	79-86
2526171-3	1989	Serum dehydroepiandrosterone sulphate (DHEA-S) exceeded 10,000 ng/ml (normal 2,000-3,350 ng/ml).	Dehydroepiandrosterone Sulfate	6-37	sulfotransferase family 2A member 1	Homo sapiens	39-45
2527206-0	1989	Quantification of epidermal growth factor in human breast cyst fluids: correlation with dehydroepiandrosterone-sulphate and electrolyte concentrations.	Dehydroepiandrosterone Sulfate	88-119	epidermal growth factor	Homo sapiens	18-41
2527206-4	1989	Furthermore, the relationship between EGF and [Na+] and [K+] and between EGF and DHA-sulphate seemed to differ between the 2 cyst types and each cyst type was therefore analyzed separately.	Dehydroepiandrosterone Sulfate	81-93	epidermal growth factor	Homo sapiens	73-76
2523898-0	1989	Relationship between insulin, insulin-like growth factor I, and dehydroepiandrosterone sulfate concentrations during childhood, puberty, and adult life.	Dehydroepiandrosterone Sulfate	64-94	insulin	Homo sapiens	21-28
2523898-1	1989	The relationships between plasma insulin, insulin-like growth factor I (IGF-I) and dehydroepiandrosterone sulfate (DHEAS) concentrations in normal subjects have not been defined.	Dehydroepiandrosterone Sulfate	83-113	insulin like growth factor 1	Homo sapiens	42-70
2523898-1	1989	The relationships between plasma insulin, insulin-like growth factor I (IGF-I) and dehydroepiandrosterone sulfate (DHEAS) concentrations in normal subjects have not been defined.	Dehydroepiandrosterone Sulfate	83-113	insulin like growth factor 1	Homo sapiens	72-77
2523898-1	1989	The relationships between plasma insulin, insulin-like growth factor I (IGF-I) and dehydroepiandrosterone sulfate (DHEAS) concentrations in normal subjects have not been defined.	Dehydroepiandrosterone Sulfate	83-113	sulfotransferase family 2A member 1	Homo sapiens	115-120
2533306-4	1989	Steroid sulphatase can be measured specifically with 4-methylumbelliferylsulphate as the fraction of total ASC activity which is inhibitable by dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	144-175	steroid sulfatase	Homo sapiens	0-18
2533306-4	1989	Steroid sulphatase can be measured specifically with 4-methylumbelliferylsulphate as the fraction of total ASC activity which is inhibitable by dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	144-175	steroid sulfatase	Homo sapiens	107-110
2533954-5	1989	There was a tendency to lower levels of DHEAS in the infected group by comparison with controls (54.92 +/- 37.34 micrograms/dl vs 66.80 +/- 47.18 micrograms/dl) while in the same infected group more subjects had higher levels of prolactin by comparison with the control group (10.85 +/- 14.16 ng/ml vs 9.80 +/- 5.56 ng/ml).	Dehydroepiandrosterone Sulfate	40-45	prolactin	Homo sapiens	229-238
2849878-6	1988	The addition of adrenocorticotropic hormone, forskolin, 22R-hydroxycholesterol, or dibutyryl cyclic adenosine monophosphate increased the secretion of dehydroepiandrosterone sulfate and cortisol twofold to threefold and twofold to sixfold, respectively, above basal rates.	Dehydroepiandrosterone Sulfate	151-181	proopiomelanocortin	Homo sapiens	16-43
2971432-10	1988	In addition, a direct correlation was found between EGF and DHEA-S concentrations.	Dehydroepiandrosterone Sulfate	60-66	epidermal growth factor	Homo sapiens	52-55
2848596-4	1988	When human fetal adrenal cells were incubated in the continuous presence of 10(-8) M ACTH for 72 h, DHAS production was increased compared to that of the untreated cultures (5-fold at 24 h and 50-fold at 72 h), and the cells remained responsive during the entire experimental period.	Dehydroepiandrosterone Sulfate	100-104	proopiomelanocortin	Homo sapiens	85-89
2848596-7	1988	One of the steroidogenic enzymatic steps stimulated by ACTH pretreatment was that of 17 alpha-hydroxylase/17, 20-lyase, since conversion of pregnenolone and 17 alpha-hydroxypregnenolone to DHAS was increased in a dose-dependent manner.	Dehydroepiandrosterone Sulfate	189-193	proopiomelanocortin	Homo sapiens	55-59
3220046-2	1988	Her baseline and ACTH-stimulated plasma 17-hydroxy pregnenolone, dehydroepiandrosterone and dehydroepiandrosterone sulfate were increased whereas plasma 17-hydroxy progesterone and androstenedione were normal and responded poorly to ACTH.	Dehydroepiandrosterone Sulfate	92-122	proopiomelanocortin	Homo sapiens	17-21
3369475-4	1988	Dehydroepiandrosterone sulfate (DHEAS), which is low before pregnancy and during the first week of gestation, tends to increase later.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
3264254-5	1988	Time-course studies indicated that the effects were detectable at 12 h, and continued to increase up to 48 h. The conversion of added dehydroepiandrosterone sulfate (DHEAS) to E2 was stimulated by CT and TPA and inhibited by IGF-I in a concentration-dependent manner.	Dehydroepiandrosterone Sulfate	134-164	plasminogen activator, tissue type	Homo sapiens	204-207
3264254-5	1988	Time-course studies indicated that the effects were detectable at 12 h, and continued to increase up to 48 h. The conversion of added dehydroepiandrosterone sulfate (DHEAS) to E2 was stimulated by CT and TPA and inhibited by IGF-I in a concentration-dependent manner.	Dehydroepiandrosterone Sulfate	134-164	insulin like growth factor 1	Homo sapiens	225-230
3264254-5	1988	Time-course studies indicated that the effects were detectable at 12 h, and continued to increase up to 48 h. The conversion of added dehydroepiandrosterone sulfate (DHEAS) to E2 was stimulated by CT and TPA and inhibited by IGF-I in a concentration-dependent manner.	Dehydroepiandrosterone Sulfate	166-171	plasminogen activator, tissue type	Homo sapiens	204-207
2965660-3	1988	Since there is evidence that 5-androstene-3 beta, 17 beta-diol (delta 5-diol), a metabolite of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) can induce typical oestrogenic responses in target tissues, we have investigated the effect of C19 adrenal steroids and compared them to that of 17 beta-oestradiol (E2) on the above-indicated parameters.	Dehydroepiandrosterone Sulfate	129-141	sulfotransferase family 2A member 1	Homo sapiens	143-149
3264254-5	1988	Time-course studies indicated that the effects were detectable at 12 h, and continued to increase up to 48 h. The conversion of added dehydroepiandrosterone sulfate (DHEAS) to E2 was stimulated by CT and TPA and inhibited by IGF-I in a concentration-dependent manner.	Dehydroepiandrosterone Sulfate	166-171	insulin like growth factor 1	Homo sapiens	225-230
2978280-0	1988	Dehydroepiandrosterone sulfate (DHEA-S) and DHEA-S-like compounds in fibrocystic disease of the breast.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-38
2967305-0	1988	Divergent correlations of circulating dehydroepiandrosterone sulfate and testosterone with insulin levels and insulin receptor binding.	Dehydroepiandrosterone Sulfate	38-68	insulin	Homo sapiens	91-98
2967305-0	1988	Divergent correlations of circulating dehydroepiandrosterone sulfate and testosterone with insulin levels and insulin receptor binding.	Dehydroepiandrosterone Sulfate	38-68	insulin	Homo sapiens	110-117
2957384-1	1987	Serum dehydroepiandrosterone sulfate (DHEA-S) concentrations were studied in 84 untreated patients with secondary adrenal insufficiency.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-44
2967730-0	1988	[Blood levels of dehydroepiandrosterone sulfate (DHEA-S) and the risk of breast cancer].	Dehydroepiandrosterone Sulfate	17-47	sulfotransferase family 2A member 1	Homo sapiens	49-55
3190352-4	1988	Only in men the androgen receptor content and dehydroepiandrosterone-sulphate levels were inversely correlated to beta-glucuronidase.	Dehydroepiandrosterone Sulfate	46-77	glucuronidase beta	Homo sapiens	114-132
3347051-8	1988	In the absence of microsomes, and in the presence of microsomal fractions from the sulfatase-deficient placenta, the hydrolysis of DOC-SO4 and DS was not detected.	Dehydroepiandrosterone Sulfate	143-145	arylsulfatase family member H	Homo sapiens	83-92
2960747-1	1987	A new method for determination of cholesterol sulfate (CS) and dehydroepiandrosterone sulfate (DHEAS) from 1 ml serum by reverse phase thin-layer chromatography (TLC) is described.	Dehydroepiandrosterone Sulfate	63-93	sulfotransferase family 2A member 1	Homo sapiens	95-100
3654629-0	1987	P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate.	Dehydroepiandrosterone Sulfate	104-136	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	0-10
3654629-0	1987	P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate.	Dehydroepiandrosterone Sulfate	104-136	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	22-38
3654629-4	1987	Antibodies to P-450 HFLa inhibited the 16 alpha-hydroxylation of DHEA-sulfate in a dose-dependent manner.	Dehydroepiandrosterone Sulfate	65-77	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	14-24
3654629-11	1987	We conclude that P-450 HFLa is a form of cytochrome P-450 involved in the 16 alpha-hydroxylation of DHEA-sulfate.	Dehydroepiandrosterone Sulfate	100-112	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	17-27
3654629-11	1987	We conclude that P-450 HFLa is a form of cytochrome P-450 involved in the 16 alpha-hydroxylation of DHEA-sulfate.	Dehydroepiandrosterone Sulfate	100-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	41-57
3436298-4	1987	In the presence of 10(-7) M adrenocorticotropin (ACTH), the addition of either LDL or HDL to the culture medium at a cholesterol concentration of 100 micrograms/ml led to a significant increase in the daily secretion rates of cortisol, dehydroepiandrosterone sulfate (DHEA-S) and aldosterone in the adenoma and nodular hyperplasia cells, as in the normal cells.	Dehydroepiandrosterone Sulfate	236-266	proopiomelanocortin	Homo sapiens	49-53
3436298-4	1987	In the presence of 10(-7) M adrenocorticotropin (ACTH), the addition of either LDL or HDL to the culture medium at a cholesterol concentration of 100 micrograms/ml led to a significant increase in the daily secretion rates of cortisol, dehydroepiandrosterone sulfate (DHEA-S) and aldosterone in the adenoma and nodular hyperplasia cells, as in the normal cells.	Dehydroepiandrosterone Sulfate	268-274	proopiomelanocortin	Homo sapiens	49-53
3036902-4	1987	The increases in both serum cortisol and adrenal androgens, including DHEA sulfate, in response to short term ACTH infusion (40 U in 6 h) in ACTH-intact hypopituitary children were normal or above normal, while these steroid responses were significantly (P less than 0.05-0.01) lower in ACTH-deficient hypopituitary children compared to normal values.	Dehydroepiandrosterone Sulfate	70-82	proopiomelanocortin	Homo sapiens	110-114
3036902-4	1987	The increases in both serum cortisol and adrenal androgens, including DHEA sulfate, in response to short term ACTH infusion (40 U in 6 h) in ACTH-intact hypopituitary children were normal or above normal, while these steroid responses were significantly (P less than 0.05-0.01) lower in ACTH-deficient hypopituitary children compared to normal values.	Dehydroepiandrosterone Sulfate	70-82	proopiomelanocortin	Homo sapiens	141-145
3036902-4	1987	The increases in both serum cortisol and adrenal androgens, including DHEA sulfate, in response to short term ACTH infusion (40 U in 6 h) in ACTH-intact hypopituitary children were normal or above normal, while these steroid responses were significantly (P less than 0.05-0.01) lower in ACTH-deficient hypopituitary children compared to normal values.	Dehydroepiandrosterone Sulfate	70-82	proopiomelanocortin	Homo sapiens	141-145
3041110-3	1987	Serum dehydroepiandrosterone sulphate (DHEA-S) concentrations were also increased during ACTH therapy above the normal prepubertal range.	Dehydroepiandrosterone Sulfate	6-37	proopiomelanocortin	Homo sapiens	89-93
3297813-3	1987	A strong negative correlation was demonstrated between fasting insulin and dehydroepiandrosterone sulfate (DHEAS) levels within the HA group (r = -0.84, P = 0.003).	Dehydroepiandrosterone Sulfate	75-105	insulin	Homo sapiens	63-70
3297813-3	1987	A strong negative correlation was demonstrated between fasting insulin and dehydroepiandrosterone sulfate (DHEAS) levels within the HA group (r = -0.84, P = 0.003).	Dehydroepiandrosterone Sulfate	107-112	insulin	Homo sapiens	63-70
2953750-8	1987	The apparent Km values of steroid sulfatase for estrone sulfate in both squamous vaginal carcinoma cells and ovarian carcinoma cells were both 5 microM, and those for dehydroepiandrosterone sulfate in squamous vaginal carcinoma cells and endometrial adenocarcinoma cells were 6 and 4 microM, respectively.	Dehydroepiandrosterone Sulfate	167-197	arylsulfatase family member H	Homo sapiens	34-43
3034954-8	1987	The production of both dehydroepiandrosterone sulfate and cortisol also was stimulated by ACTH, suggesting that the increased mRNAs were translated into active enzymes.	Dehydroepiandrosterone Sulfate	23-53	proopiomelanocortin	Homo sapiens	90-94
2886380-2	1987	A highly statistically significant positive correlation between lumbar-3 spongiosum density and both dehydroepiandrosterone-sulfate (DHEA-S), r = 0.67; P less than 0.005 and androstenedione (A), r = 0.56; P less than 0.03 was found.	Dehydroepiandrosterone Sulfate	101-131	sulfotransferase family 2A member 1	Homo sapiens	133-139
3028128-8	1987	Baseline levels of the adrenal androgens dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were significantly lower in the subjects with thalassemia compared with controls of similar bone age and pubertal status.	Dehydroepiandrosterone Sulfate	75-105	sulfotransferase family 2A member 1	Homo sapiens	107-113
2972168-0	1987	A relationship between sex hormone binding globulin and dehydroepiandrosterone sulfate in normally menstruating females.	Dehydroepiandrosterone Sulfate	56-86	sex hormone binding globulin	Homo sapiens	23-51
2972168-3	1987	There was an inverse relationship between SHBG and DHEAS, but no relationship between T or E2 and SHBG levels.	Dehydroepiandrosterone Sulfate	51-56	sex hormone binding globulin	Homo sapiens	42-46
2972168-4	1987	There is at present no model which readily explains this inverse relationship between SHBG and DHEAS in normal subjects.	Dehydroepiandrosterone Sulfate	95-100	sex hormone binding globulin	Homo sapiens	86-90
2950219-5	1987	Insulin sensitivity correlated inversely with body mass index (r = -0.49, P less than 0.02), serum dehydroepiandrosterone sulphate concentration (r = -0.57, P less than 0.01), and log somatomedin C/insulinlike growth factor I (r = -0.45, P less than 0.05).	Dehydroepiandrosterone Sulfate	99-130	insulin	Homo sapiens	0-7
2953635-6	1987	SmC/IGF 1 increased both LH/hCG binding (4.3-fold), basal testosterone (4-fold) and DHAS- and hCG-stimulated testosterone and DHAS (dehydroepiandrosterone sulfate) production (15.5- and 6.4-fold respectively).	Dehydroepiandrosterone Sulfate	84-88	insulin like growth factor 1	Homo sapiens	4-9
2953635-6	1987	SmC/IGF 1 increased both LH/hCG binding (4.3-fold), basal testosterone (4-fold) and DHAS- and hCG-stimulated testosterone and DHAS (dehydroepiandrosterone sulfate) production (15.5- and 6.4-fold respectively).	Dehydroepiandrosterone Sulfate	126-130	insulin like growth factor 1	Homo sapiens	4-9
2953635-6	1987	SmC/IGF 1 increased both LH/hCG binding (4.3-fold), basal testosterone (4-fold) and DHAS- and hCG-stimulated testosterone and DHAS (dehydroepiandrosterone sulfate) production (15.5- and 6.4-fold respectively).	Dehydroepiandrosterone Sulfate	132-162	insulin like growth factor 1	Homo sapiens	4-9
2950000-0	1987	Elevated serum dehydroepiandrosterone sulfate levels in patients with insulin resistance, hirsutism, and acanthosis nigricans.	Dehydroepiandrosterone Sulfate	15-45	insulin	Homo sapiens	70-77
3748660-5	1986	Conversely, umbilical serum concentrations of dehydroepiandrosterone sulfate in newborns of women with severe PIH were significantly less (p less than 0.05) than those in newborns of women with uncomplicated pregnancies.	Dehydroepiandrosterone Sulfate	46-76	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	110-113
2956173-1	1987	Serum levels of dehydroepiandrosterone sulfate (DHEAS) were measured in 41 postmenopausal women with ovarian tumor (16 with ovarian cancer, 6 with borderline malignant and 19 with benign ovarian tumor) and in 21 postmenopausal women without ovarian neoplasm.	Dehydroepiandrosterone Sulfate	16-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
2946716-7	1987	Dehydroepiandrosterone sulfate (DHEA-S) levels, however, uniformly and progressively decreased by 39% after 12 h of insulin infusion in the normal women and by 31% at 14 h in the woman with hyperandrogenism, insulin resistance, and acanthosis nigricans.	Dehydroepiandrosterone Sulfate	0-30	insulin	Homo sapiens	116-123
2946716-7	1987	Dehydroepiandrosterone sulfate (DHEA-S) levels, however, uniformly and progressively decreased by 39% after 12 h of insulin infusion in the normal women and by 31% at 14 h in the woman with hyperandrogenism, insulin resistance, and acanthosis nigricans.	Dehydroepiandrosterone Sulfate	32-38	insulin	Homo sapiens	116-123
2946716-10	1987	These results indicate that acute hyperinsulinemia of 12- to 16-h duration does not increase serum testosterone or DHEA-S concentrations and, indeed, can cause a decline in serum DHEA-S levels in both normal women and the single woman studied with hyperandrogenism, insulin resistance, and acanthosis nigricans.	Dehydroepiandrosterone Sulfate	179-185	insulin	Homo sapiens	39-46
2955123-1	1987	Human studies of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have shown age-related changes in serum levels of these two sex hormone precursors.	Dehydroepiandrosterone Sulfate	51-81	sulfotransferase family 2A member 1	Homo sapiens	83-89
2955423-5	1987	By contrast, in clinically healthy women, the phi of plasma dehydroepiandrosterone sulfate (DHEA-S) lags behind that of cortisol (F), on the average by 6 hr 28 min.	Dehydroepiandrosterone Sulfate	60-90	sulfotransferase family 2A member 1	Homo sapiens	92-98
2946952-1	1986	It has been postulated that dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS), the major secretory products of the human adrenal gland, may be discriminators of life expectancy and aging.	Dehydroepiandrosterone Sulfate	81-111	sulfotransferase family 2A member 1	Homo sapiens	113-118
3027457-10	1986	E2DH, but not aromatase activity, was significantly higher in E2R+ than in E2R- tissues and was negatively correlated with tissue dehydroepiandrosterone (DHEA) and DHEAS conc.	Dehydroepiandrosterone Sulfate	164-169	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	0-4
3018031-5	1986	After the addition of ACTH (10(-10)-10(-5) M), DS and cAMP secretion increased.	Dehydroepiandrosterone Sulfate	47-49	proopiomelanocortin	Homo sapiens	22-26
3018031-6	1986	The addition of EGTA to the medium inhibited ACTH- and forskolin-stimulated DS, F, and cAMP secretion by 50% as well as (Bu)2cAMP-stimulated steroidogenesis.	Dehydroepiandrosterone Sulfate	76-78	proopiomelanocortin	Homo sapiens	45-49
2942557-5	1986	The addition of DHEAS resulted in secretion of E1 and E2; at a concentration of 500 ng DHEAS/ml, the secretion of E1 (1 +/- 0.16) and E2 (11 +/- 3.1) was maximal, while E3 remained undetectable.	Dehydroepiandrosterone Sulfate	16-21	small nucleolar RNA, H/ACA box 73A	Homo sapiens	47-56
2942557-5	1986	The addition of DHEAS resulted in secretion of E1 and E2; at a concentration of 500 ng DHEAS/ml, the secretion of E1 (1 +/- 0.16) and E2 (11 +/- 3.1) was maximal, while E3 remained undetectable.	Dehydroepiandrosterone Sulfate	87-92	small nucleolar RNA, H/ACA box 73A	Homo sapiens	47-56
2942557-7	1986	The addition of increasing concentrations of DHEAS to cultures exposed to 1000 ng 16OH-DHEAS/ml caused a decrease in E3 secretion and increased secretion of E1 and E2.	Dehydroepiandrosterone Sulfate	45-50	small nucleolar RNA, H/ACA box 73A	Homo sapiens	157-166
2942557-8	1986	Conversely, addition of increasing concentrations of 16OH-DHEAS in cultures exposed to 500 ng DHEAS/ml resulted in inhibition of E1 and E2 secretion and increased E3 secretion.	Dehydroepiandrosterone Sulfate	58-63	small nucleolar RNA, H/ACA box 73A	Homo sapiens	129-137
2942557-8	1986	Conversely, addition of increasing concentrations of 16OH-DHEAS in cultures exposed to 500 ng DHEAS/ml resulted in inhibition of E1 and E2 secretion and increased E3 secretion.	Dehydroepiandrosterone Sulfate	94-99	small nucleolar RNA, H/ACA box 73A	Homo sapiens	129-137
2942557-9	1986	A concentration of 16OH-DHEAS that inhibited the conversion of DHEAS into E1 and E2 neither altered the intracellular to extracellular steroid ratios (approximately 0.1) nor reduced the secretion of DHEA, androstenedione, and testosterone.	Dehydroepiandrosterone Sulfate	24-29	small nucleolar RNA, H/ACA box 73A	Homo sapiens	74-83
3018031-8	1986	In the presence of ACTH and (Bu)2cAMP, however, increasing amounts of calcium resulted in a 2- to 3-fold increase in the rates of DS and F secretion.	Dehydroepiandrosterone Sulfate	130-132	proopiomelanocortin	Homo sapiens	19-23
3018031-9	1986	The addition of either A23187, a calcium ionophore, or verapamil, a calcium channel blocker, inhibited ACTH-stimulated DS and F secretion by 90%.	Dehydroepiandrosterone Sulfate	119-121	proopiomelanocortin	Homo sapiens	103-107
3017633-1	1986	To further characterize the adrenocortical response to acute illness, we measured basal and adrenocorticotropic hormone (ACTH)-stimulated 11-deoxycortisol, androstenedione, and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	177-207	proopiomelanocortin	Homo sapiens	92-119
2940256-1	1986	In a study of 16 men and 55 women with temporal lobe epilepsy (TLE), we found that the serum dehydroepiandrosterone sulfate (DHEA-S) level was significantly lower (P less than 0.05) in patients who were treated with phenytoin (mean +/- SD DHEA-S in men, 685 +/- 429 ng/ml; in women, 580 +/- 289), carbamazepine (women, 779 +/- 529), or a combination of the two drugs (men, 491 +/- 246; women, 474 +/- 284) than in age- and sex-matched untreated patients (men, 2634 +/- 418; women, 2011 +/- 1435) or in normal subjects (men, 2870 +/- 1052; women, 1764 +/- 617).	Dehydroepiandrosterone Sulfate	93-123	sulfotransferase family 2A member 1	Homo sapiens	125-131
2940256-1	1986	In a study of 16 men and 55 women with temporal lobe epilepsy (TLE), we found that the serum dehydroepiandrosterone sulfate (DHEA-S) level was significantly lower (P less than 0.05) in patients who were treated with phenytoin (mean +/- SD DHEA-S in men, 685 +/- 429 ng/ml; in women, 580 +/- 289), carbamazepine (women, 779 +/- 529), or a combination of the two drugs (men, 491 +/- 246; women, 474 +/- 284) than in age- and sex-matched untreated patients (men, 2634 +/- 418; women, 2011 +/- 1435) or in normal subjects (men, 2870 +/- 1052; women, 1764 +/- 617).	Dehydroepiandrosterone Sulfate	93-123	sulfotransferase family 2A member 1	Homo sapiens	239-245
3463506-9	1986	The addition of DHA-sulfate and DHA inhibited 20 alpha-HSD activity for progesterone significantly, suggesting that the steroid produced by the feto-placental unit may be involved in the metabolism of progesterone in human placenta.	Dehydroepiandrosterone Sulfate	16-27	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	46-58
2939721-5	1986	Dehydroepiandrosterone sulfate added to Dulbecco"s modified Eagle"s medium was actively converted into C-19 and C-18 steroids but had no significant effect (up to 20 micrograms/ml) on basal (de novo) progesterone secretion.	Dehydroepiandrosterone Sulfate	0-30	Bardet-Biedl syndrome 9	Homo sapiens	112-116
2424236-1	1986	Steroid sulphatase (STS) activity was measured with tritiated dehydroepiandrosterone sulphate (DHEAS) and oestrone sulphate (OES) in leucocytes as well as in skin fibroblasts from 31 women who were presumed to be carriers of STS deficiency and recessive X-linked ichthyosis.	Dehydroepiandrosterone Sulfate	62-93	steroid sulfatase	Homo sapiens	0-18
2942557-10	1986	The inhibitory effect of 16OH-DHEAS was minimal at low DHEAS concentrations (favoring the secretion of E1 and E2) and was greatly enhanced at concentrations of DHEAS that induced maximum E1 and E2 secretions.	Dehydroepiandrosterone Sulfate	30-35	small nucleolar RNA, H/ACA box 73A	Homo sapiens	103-112
2942557-10	1986	The inhibitory effect of 16OH-DHEAS was minimal at low DHEAS concentrations (favoring the secretion of E1 and E2) and was greatly enhanced at concentrations of DHEAS that induced maximum E1 and E2 secretions.	Dehydroepiandrosterone Sulfate	30-35	small nucleolar RNA, H/ACA box 73A	Homo sapiens	187-196
2942557-10	1986	The inhibitory effect of 16OH-DHEAS was minimal at low DHEAS concentrations (favoring the secretion of E1 and E2) and was greatly enhanced at concentrations of DHEAS that induced maximum E1 and E2 secretions.	Dehydroepiandrosterone Sulfate	55-60	small nucleolar RNA, H/ACA box 73A	Homo sapiens	103-112
2942557-11	1986	The results indicate that in trophoblastic cells, the metabolism of DHEAS can modulate E3 secretion, and the metabolism of 16OH-DHEAS can modulate the secretion of E1 and E2; and this regulatory mechanism appears to take place at the level of the aromatase system.	Dehydroepiandrosterone Sulfate	128-133	small nucleolar RNA, H/ACA box 73A	Homo sapiens	164-173
6237915-6	1984	Alternatively, the relative increase in tumor metabolism of androgens inferred from high 7 alpha OHDHA/DHAS and DHA/DHAS ratios in the ER- group may disrupt the hormonal microenvironment of the estrogen receptor.	Dehydroepiandrosterone Sulfate	116-120	estrogen receptor 1	Homo sapiens	194-211
2935348-3	1986	The clinical findings, family history, and serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) were compared in 24 children with PA (79% black females) seen in a 2-year period and in an age-matched control group of 17 black females.	Dehydroepiandrosterone Sulfate	67-97	sulfotransferase family 2A member 1	Homo sapiens	99-105
2949906-3	1986	It was also shown that both purified ABG-S and plasma ABG bind reversibly, with high affinity (Ka = 1.6 X 10(-9) M, Scatchard plot) to dehydroepiandrosterone sulfate (DHEA-S) to binding sites different from those for aldosterone.	Dehydroepiandrosterone Sulfate	135-165	alpha-1-B glycoprotein	Homo sapiens	37-40
2949906-3	1986	It was also shown that both purified ABG-S and plasma ABG bind reversibly, with high affinity (Ka = 1.6 X 10(-9) M, Scatchard plot) to dehydroepiandrosterone sulfate (DHEA-S) to binding sites different from those for aldosterone.	Dehydroepiandrosterone Sulfate	135-165	alpha-1-B glycoprotein	Homo sapiens	54-57
2949906-3	1986	It was also shown that both purified ABG-S and plasma ABG bind reversibly, with high affinity (Ka = 1.6 X 10(-9) M, Scatchard plot) to dehydroepiandrosterone sulfate (DHEA-S) to binding sites different from those for aldosterone.	Dehydroepiandrosterone Sulfate	135-165	sulfotransferase family 2A member 1	Homo sapiens	167-173
3005444-3	1986	The injection of DHA-S produced a small increase in the plasma 2-mE2 levels in spite of a marked increase in the plasma E2 concentration.	Dehydroepiandrosterone Sulfate	17-22	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	65-68
3005444-3	1986	The injection of DHA-S produced a small increase in the plasma 2-mE2 levels in spite of a marked increase in the plasma E2 concentration.	Dehydroepiandrosterone Sulfate	17-22	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	66-68
3005444-5	1986	The marked increase in 2-mE1 compared to a small increase in 2-mE2 after DHA-S injection indicates that E2 may participate in the formation of catecholestrogen via its conversion to E1 during pregnancy.	Dehydroepiandrosterone Sulfate	73-78	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	63-66
3005444-5	1986	The marked increase in 2-mE1 compared to a small increase in 2-mE2 after DHA-S injection indicates that E2 may participate in the formation of catecholestrogen via its conversion to E1 during pregnancy.	Dehydroepiandrosterone Sulfate	73-78	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	64-66
3155698-1	1985	Serum dehydroepiandrosterone sulfate (DHEA-S) is frequently elevated in anovulatory women.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-44
2945969-1	1986	An enzyme immunological methodology for the direct and simultaneous estimation of serum cortisol and dehydroepiandrosterone-sulphate (DHEA-S) useful for the biochemical differential diagnosis of Cushing"s syndrome has been developed.	Dehydroepiandrosterone Sulfate	101-132	sulfotransferase family 2A member 1	Homo sapiens	134-140
2997263-3	1985	Maternal adrenal suppression was evidenced by a sharp fall of plasma cortisol (F), cortisone (E), corticosterone (B), and dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	122-152	sulfotransferase family 2A member 1	Homo sapiens	154-160
2936600-1	1985	We investigated the mechanism of dissociation of cortisol and dehydroepiandrosterone sulfate (DHEA-S) secretion by the adrenal glands after the removal of an adrenal gland containing an adrenocortical adenoma in a patient with Cushing"s syndrome.	Dehydroepiandrosterone Sulfate	62-92	sulfotransferase family 2A member 1	Homo sapiens	94-100
2993344-9	1985	The recovery of somatomedin-C before the recovery of adrenal androgens, however, and the positive correlation between plasma somatomedin-C and the integrated level of plasma DHAS (r = 0.50; P less than 0.02) are consistent with the hypothesis that somatomedin-C is a stimulus for adrenal androgen secretion.	Dehydroepiandrosterone Sulfate	174-178	insulin like growth factor 1	Homo sapiens	125-138
2993344-9	1985	The recovery of somatomedin-C before the recovery of adrenal androgens, however, and the positive correlation between plasma somatomedin-C and the integrated level of plasma DHAS (r = 0.50; P less than 0.02) are consistent with the hypothesis that somatomedin-C is a stimulus for adrenal androgen secretion.	Dehydroepiandrosterone Sulfate	174-178	insulin like growth factor 1	Homo sapiens	125-138
2939335-0	1985	[Relation between prolactin and dehydroepiandrosterone sulfate in women with polycystic ovary disease].	Dehydroepiandrosterone Sulfate	32-62	prolactin	Homo sapiens	18-27
2997888-1	1985	Plasma values for digitalis like factors (DLF) and dehydroepiandrosterone sulfate (DHEA-S) in 11 healthy adults were (mean +/- SD) 44 +/- 6 pmol digoxin equivalents/L and 11 +/- 3 mumol/L respectively.	Dehydroepiandrosterone Sulfate	51-81	sulfotransferase family 2A member 1	Homo sapiens	83-89
3160598-1	1985	Intravenous application of dehydroepiandrosterone sulphate (DHEA-S) was performed in 6 women with normal progress of pregnancy, 3 pregnant women with multiple pregnancy and 4 pregnants with intrauterine death of the foetus (32nd to 38th week).	Dehydroepiandrosterone Sulfate	27-58	sulfotransferase family 2A member 1	Homo sapiens	60-66
6238041-1	1984	Serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) were measured in patients with hyperadrenocorticism.	Dehydroepiandrosterone Sulfate	24-54	sulfotransferase family 2A member 1	Homo sapiens	56-62
6237915-6	1984	Alternatively, the relative increase in tumor metabolism of androgens inferred from high 7 alpha OHDHA/DHAS and DHA/DHAS ratios in the ER- group may disrupt the hormonal microenvironment of the estrogen receptor.	Dehydroepiandrosterone Sulfate	103-107	estrogen receptor 1	Homo sapiens	135-137
6237915-6	1984	Alternatively, the relative increase in tumor metabolism of androgens inferred from high 7 alpha OHDHA/DHAS and DHA/DHAS ratios in the ER- group may disrupt the hormonal microenvironment of the estrogen receptor.	Dehydroepiandrosterone Sulfate	103-107	estrogen receptor 1	Homo sapiens	194-211
6237915-6	1984	Alternatively, the relative increase in tumor metabolism of androgens inferred from high 7 alpha OHDHA/DHAS and DHA/DHAS ratios in the ER- group may disrupt the hormonal microenvironment of the estrogen receptor.	Dehydroepiandrosterone Sulfate	116-120	estrogen receptor 1	Homo sapiens	135-137
6238998-0	1984	Effects of dehydroepiandrosterone-sulphate (DHEA-S) administration on puerperal lactation and maternal prolactin and estradiol levels.	Dehydroepiandrosterone Sulfate	11-42	sulfotransferase family 2A member 1	Homo sapiens	44-50
6090494-2	1984	In women with hyperprolactinemia whose pituitary-adrenal function was normal, there was significant correlation between serum PRL and dehydroepiandrosterone sulfate [(DHEA-S) gamma = 0.48, P less than 0.05, n = 34] and DHEA (gamma = 0.50, P less than 0.05, n = 34), but not with androstenedione.	Dehydroepiandrosterone Sulfate	134-164	prolactin	Homo sapiens	126-129
6235099-1	1984	Twenty-six healthy, non-hirsute women had antecubital venous blood obtained before and during treatment with various contraceptive steroids for the measurement of dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	163-193	sulfotransferase family 2A member 1	Homo sapiens	195-201
6235239-1	1984	Serum levels of testosterone (T), dehydroepiandrosterone (DHEA), and DHEA sulfate (DHEA-S) were measured in a group of 285 women with clinical signs of hyperandrogenism (hirsutism and/or acne).	Dehydroepiandrosterone Sulfate	69-81	sulfotransferase family 2A member 1	Homo sapiens	83-89
6233132-1	1984	Using microsomes isolated from term human placentae kinetic analyses of each of the enzymes involved in estrogen synthesis from dehydroepiandrosterone sulfate have been carried out and the following parameters were found: sulfatase, Michaelis-Menten constant (Km) = 16,000 +/- 5,000 nM, maximum velocity (Vm) = 2.0 +/- 0.5 nmol X min-1 X mg protein-1; 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), Km = 15 +/- 3 nM, Vm = 1.8 +/- 0.4 nmol X min-1 X mg protein-1; aromatase, Km = 14 +/- 4 nM, Vm = 0.12 +/- 0.02 nmol X min-1 X mg protein-1.	Dehydroepiandrosterone Sulfate	128-158	arylsulfatase family member H	Homo sapiens	222-231
6233132-1	1984	Using microsomes isolated from term human placentae kinetic analyses of each of the enzymes involved in estrogen synthesis from dehydroepiandrosterone sulfate have been carried out and the following parameters were found: sulfatase, Michaelis-Menten constant (Km) = 16,000 +/- 5,000 nM, maximum velocity (Vm) = 2.0 +/- 0.5 nmol X min-1 X mg protein-1; 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), Km = 15 +/- 3 nM, Vm = 1.8 +/- 0.4 nmol X min-1 X mg protein-1; aromatase, Km = 14 +/- 4 nM, Vm = 0.12 +/- 0.02 nmol X min-1 X mg protein-1.	Dehydroepiandrosterone Sulfate	128-158	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	389-399
6233132-2	1984	From these values one can predict that, theoretically, the rate-limiting enzyme in estrogen synthesis from dehydroepiandrosterone sulfate (DS) should change from the sulfatase at low concentrations of substrate to the aromatase at higher concentrations.	Dehydroepiandrosterone Sulfate	107-137	arylsulfatase family member H	Homo sapiens	166-175
6233132-2	1984	From these values one can predict that, theoretically, the rate-limiting enzyme in estrogen synthesis from dehydroepiandrosterone sulfate (DS) should change from the sulfatase at low concentrations of substrate to the aromatase at higher concentrations.	Dehydroepiandrosterone Sulfate	139-141	arylsulfatase family member H	Homo sapiens	166-175
6235986-2	1984	In this study we have evaluated a simple protocol determining the serum oestradiol response to 50 mg of dehydroepiandrosterone sulphate (DHEAS) given intravenously to twelve women with low serum or urinary oestrogens.	Dehydroepiandrosterone Sulfate	104-135	sulfotransferase family 2A member 1	Homo sapiens	137-142
6327404-2	1984	Fifty percent of these patients exhibited increased AA secretion, as evidenced by an elevated serum dehydroepiandrosterone sulfate (DHEA-S) level.	Dehydroepiandrosterone Sulfate	100-130	sulfotransferase family 2A member 1	Homo sapiens	132-138
6225910-1	1983	A simple method is described for the determination of androgens, particularly dehydroepiandrosterone sulfate (DHEAS), in human plasma and urine.	Dehydroepiandrosterone Sulfate	78-108	sulfotransferase family 2A member 1	Homo sapiens	110-115
6233421-6	1984	A statistically significant correlation was found between mean prolactin concentrations and the mean plasma dehydroepiandrosterone sulphate (DHEAS) concentration (r = 0.67, p less than 0.01).	Dehydroepiandrosterone Sulfate	108-139	prolactin	Homo sapiens	63-72
6233421-6	1984	A statistically significant correlation was found between mean prolactin concentrations and the mean plasma dehydroepiandrosterone sulphate (DHEAS) concentration (r = 0.67, p less than 0.01).	Dehydroepiandrosterone Sulfate	141-146	prolactin	Homo sapiens	63-72
6368991-6	1984	Using placental microsomes, the Km of dehydroepiandrosterone sulfate was determined to be 5.0 X 10(7)M. Sulfatase activity in frozen scrotal skin was found to be 2-3 fold than with vaginal skin.	Dehydroepiandrosterone Sulfate	38-68	arylsulfatase family member H	Homo sapiens	104-113
6236000-1	1984	The constant infusion technique was used to study the kinetics of dehydroepiandrosterone sulfate (DHEAS) metabolism in normal young men and women.	Dehydroepiandrosterone Sulfate	66-96	sulfotransferase family 2A member 1	Homo sapiens	98-103
6307049-8	1983	Neither beta-EP nor beta-LPH correlated with the amniotic fluid L/S ratio and only beta-LPH exhibited a significant inverse correlation with amniotic fluid DHEA-S.	Dehydroepiandrosterone Sulfate	156-162	proopiomelanocortin	Homo sapiens	83-91
6222060-7	1983	The apparent Km of sulfatase for dehydroisoandrosterone sulfate was 7 microM, and the maximum velocity was 1.0 nmol substrate hydrolyzed/100 mg lung .	Dehydroepiandrosterone Sulfate	33-63	arylsulfatase family member H	Homo sapiens	19-28
6222060-8	1983	h. The highest specific activity of lung sulfatase for [3H]dehydroisoandrosterone sulfate was found in a microsomal fraction of lung homogenate.	Dehydroepiandrosterone Sulfate	59-89	arylsulfatase family member H	Homo sapiens	41-50
6304136-8	1983	During prepuberty, DHAS levels were significantly correlated with both beta LPH and beta EP, but not ACTH.	Dehydroepiandrosterone Sulfate	19-23	proopiomelanocortin	Homo sapiens	71-79
6310259-5	1983	BLPH and BEP concentrations were significantly correlated to those of DHAS throughout prepuberty.	Dehydroepiandrosterone Sulfate	70-74	proopiomelanocortin	Homo sapiens	9-12
6310263-9	1983	The difference in the ratio DHAS/cortisol was even greater comparing these human ZR and ZF cell preparations, ranging from 18- to 44-fold basally and in response to ACTH.	Dehydroepiandrosterone Sulfate	28-32	proopiomelanocortin	Homo sapiens	165-169
6318402-5	1983	When ACTH was added to the culture medium, the secretion rate of F increased 15-fold, whereas DS and PS secretion was maintained at or near initial rates of secretion.	Dehydroepiandrosterone Sulfate	94-96	proopiomelanocortin	Homo sapiens	5-9
6306129-6	1983	At the lower doses (0.2-2 micrograms/2 ml), alpha-MSH stimulated the formation of DHAS (P less than 0.01) without stimulating the formation of cortisol.	Dehydroepiandrosterone Sulfate	82-86	proopiomelanocortin	Homo sapiens	44-53
6220924-8	1983	A significant correlation was found between bioLH and serum testosterone as well as between bioLH and serum dehydroepiandrosterone sulfate (DHEA-S) (P less than 0.05), although no correlation was found between iLH and serum DHEA-S.	Dehydroepiandrosterone Sulfate	108-138	sulfotransferase family 2A member 1	Homo sapiens	140-146
6220934-5	1983	On day 2-4 basal T and DHAS levels are 1.9 and 17.0 ng/10(6) cells/24 h. The addition of hCG stimulated T and DHAS production 19- and 6-fold respectively and the average productions were 37 and 109 ng/10(6) cells/24 h. Increasing the serum to 0.5% did not change the viability of the cultures, but increased hCG stimulated T and DHAS production (183 and 188 ng/10(6) cells/24 h).	Dehydroepiandrosterone Sulfate	23-27	chorionic gonadotropin subunit beta 5	Homo sapiens	89-92
6221767-7	1983	Stimulation by hCG led to an increase in apparent steroid production for all steroids, including estrogens, with the greatest quantities seen with DHAS (greater than 200 ng/1 X 10(6) cells/3 h).	Dehydroepiandrosterone Sulfate	147-151	hypertrichosis 2 (generalised, congenital)	Homo sapiens	15-18
6220025-9	1983	Noncompetitive inhibition of E1 sulfatase by DHEA sulfate and of DHEA sulfatase by E1 sulfate were demonstrated.	Dehydroepiandrosterone Sulfate	45-57	arylsulfatase family member H	Homo sapiens	32-41
6220934-5	1983	On day 2-4 basal T and DHAS levels are 1.9 and 17.0 ng/10(6) cells/24 h. The addition of hCG stimulated T and DHAS production 19- and 6-fold respectively and the average productions were 37 and 109 ng/10(6) cells/24 h. Increasing the serum to 0.5% did not change the viability of the cultures, but increased hCG stimulated T and DHAS production (183 and 188 ng/10(6) cells/24 h).	Dehydroepiandrosterone Sulfate	110-114	chorionic gonadotropin subunit beta 5	Homo sapiens	89-92
6220934-5	1983	On day 2-4 basal T and DHAS levels are 1.9 and 17.0 ng/10(6) cells/24 h. The addition of hCG stimulated T and DHAS production 19- and 6-fold respectively and the average productions were 37 and 109 ng/10(6) cells/24 h. Increasing the serum to 0.5% did not change the viability of the cultures, but increased hCG stimulated T and DHAS production (183 and 188 ng/10(6) cells/24 h).	Dehydroepiandrosterone Sulfate	110-114	chorionic gonadotropin subunit beta 5	Homo sapiens	89-92
6220934-13	1983	Moreover high doses of hCG (100 ng/ml) result in a lower production of steroids and an earlier plateau in the case of DHAS.	Dehydroepiandrosterone Sulfate	118-122	chorionic gonadotropin subunit beta 5	Homo sapiens	23-26
6299102-6	1983	hCG stimulation resulted in an increase in dehydroepiandrosterone sulfate and 17 beta-estradiol levels, suggesting that hCG had a stimulatory effect on the adrenal.	Dehydroepiandrosterone Sulfate	43-73	chorionic gonadotropin subunit beta 5	Homo sapiens	0-3
6299102-6	1983	hCG stimulation resulted in an increase in dehydroepiandrosterone sulfate and 17 beta-estradiol levels, suggesting that hCG had a stimulatory effect on the adrenal.	Dehydroepiandrosterone Sulfate	43-73	chorionic gonadotropin subunit beta 5	Homo sapiens	120-123
6219334-0	1983	Disproportionate suppression of dehydroepiandrosterone sulfate (DHEAS) in treated patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.	Dehydroepiandrosterone Sulfate	32-62	sulfotransferase family 2A member 1	Homo sapiens	64-69
6227379-1	1983	Previous studies in hyperprolactinaemic women have led to conflicting views about the influence of prolactin (PRL) on serum dehydroepiandrosterone sulphate (DS) levels.	Dehydroepiandrosterone Sulfate	124-155	prolactin	Homo sapiens	110-113
6227379-1	1983	Previous studies in hyperprolactinaemic women have led to conflicting views about the influence of prolactin (PRL) on serum dehydroepiandrosterone sulphate (DS) levels.	Dehydroepiandrosterone Sulfate	157-159	prolactin	Homo sapiens	110-113
6227379-2	1983	This study was designed to examine the effect of a reduction of normal levels of circulating prolactin on the serum DS concentration in twenty ovulating women treated with bromocriptine for 4 months in a double-blind crossover study.	Dehydroepiandrosterone Sulfate	116-118	prolactin	Homo sapiens	93-102
6227379-10	1983	Although the mechanism of this phenomenon is not clear, this study suggests that PRL may have a physiological role in modulating the tonic secretion or metabolism of DS.	Dehydroepiandrosterone Sulfate	166-168	prolactin	Homo sapiens	81-84
6219334-1	1983	Serum concentrations of dehydroepiandrosterone sulfate (DHEAS) were measured in 28 patients (18 females, 10 males) with congenital adrenal hyperplasia due to 21-hydroxylase deficiency who were treated with oral hydrocortisone (non-salt losers) or hydrocortisone and 9-alpha-fluorohydrocortisone (salt-losers).	Dehydroepiandrosterone Sulfate	24-54	sulfotransferase family 2A member 1	Homo sapiens	56-61
6309640-2	1983	The determination of plasma concentration of total testosterone (T), androstenedione (A) and dehydroepiandrosterone sulfate (DHEAS) appeared to be the basic investigation before to further explore the adrenal (ACTH test) and/or ovarian (gonadotropin measurements) androgen secretion.	Dehydroepiandrosterone Sulfate	93-123	sulfotransferase family 2A member 1	Homo sapiens	125-130
6220952-6	1983	The results suggest that dehydroepiandrosterone sulfate, as compared to its 16 alpha-hydroxy derivative, is the preferred substrate of the sulfatase.	Dehydroepiandrosterone Sulfate	25-55	arylsulfatase family member H	Homo sapiens	139-148
6223181-1	1983	The effect of dehydroepiandrosterone sulphate (DHA-S) and its metabolites dehydroepiandrosterone (DHA) and 5-androstene-3 beta, 17 beta-diol (ADIOL) on the activity of 17 beta-hydroxysteroid dehydrogenase in human endometrial tissue was investigated by an isotope ratio technique.	Dehydroepiandrosterone Sulfate	14-45	hydroxysteroid 17-beta dehydrogenase 7	Homo sapiens	168-204
6461353-1	1982	Dehydroepiandrosterone sulphate (DHEA-S) was given intravenously twice a week after 38 weeks gestation to ripen the uterine cervix in 20 nulliparae and 24 parous women who subsequently went into labour at term.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-39
6217610-0	1982	Correlation between levels of dehydroepiandrosterone-sulphate and prolactin in human breast cyst fluid.	Dehydroepiandrosterone Sulfate	30-61	prolactin	Homo sapiens	66-75
6283191-1	1982	Alterations in the concentration of plasma dehydroepiandrosterone sulfate (DHEA-S) and cortisol in patients with essential hypertension (EH) were investigated.	Dehydroepiandrosterone Sulfate	43-73	sulfotransferase family 2A member 1	Homo sapiens	75-81
6401852-4	1983	A less striking increase in testosterone, dihydrotestosterone, dehydroepiandrosterone (DHEA), and DHEA sulfate was noted after hCG injection.	Dehydroepiandrosterone Sulfate	98-110	chorionic gonadotropin subunit beta 5	Homo sapiens	127-130
6282920-9	1982	Both LDL and DHEAS inhibited the stimulatory effect of LRH on the output of hCG.	Dehydroepiandrosterone Sulfate	13-18	hypertrichosis 2 (generalised, congenital)	Homo sapiens	76-79
6450345-1	1981	This study was undertaken to determine whether serum dehydroepiandrosterone sulfate (DHEA-S) assays could be used in lieu of urinary 17-ketosteroid (17-KS) determinations.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	85-91
6261197-1	1981	Serum dehydroepiandrosterone sulfate (DHEAS) was measured in 32 infertility patients who were found to be ovulatory, in 37 women with oligomenorrhea, and in 52 hirsute patients under basal conditions.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-43
6459336-5	1982	While the mean levels of androgens were markedly suppressed [dehydroepiandrosterone sulfate (DHEA-S), 99%, androstenedione, 94%; testosterone, 77%; dihydrotestosterone, 73%] after adrenalectomy, estrogen concentrations fell to a much lesser extent (plasma estrone, 73%; urinary estrone, 86%; plasma estradiol, 53%; urinary estradiol, 67%).	Dehydroepiandrosterone Sulfate	61-91	sulfotransferase family 2A member 1	Homo sapiens	93-99
6458518-1	1981	Correlation coefficients for dehydroepiandrosterone sulfate (DHEAS) were determined in women on menotropin.	Dehydroepiandrosterone Sulfate	29-59	sulfotransferase family 2A member 1	Homo sapiens	61-66
6452197-1	1981	Urinary estradiol production rates, plasma estradiol, and peripheral conversion of dehydroepiandrosterone sulfate (DHEAS) to estradiol were explored in patients whose neoplasms made human chorionic gonadotropin and/or human chorionic gonadotropin beta fragments.	Dehydroepiandrosterone Sulfate	83-113	sulfotransferase family 2A member 1	Homo sapiens	115-120
152195-1	1978	The inhibitory effect of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEA-S) was tested either in vitro with the use of Clark electrode combined with polarography or in vivo using the Spirolyt apparatus.	Dehydroepiandrosterone Sulfate	59-90	sulfotransferase family 2A member 1	Homo sapiens	92-98
6449151-0	1980	Prolactin modulation of dehydroepiandrosterone sulfate secretion.	Dehydroepiandrosterone Sulfate	24-54	prolactin	Homo sapiens	0-9
6449151-1	1980	To clarify the controversy about the effect of prolactin (PRL) on dehydroepiandrosterone sulfate (DHEA-S), this study was undertaken to investigate the effects of alterations in plasma PRL on plasma DHEA-S concentrations in hyperprolactinemic women, as well as in normal male subjects.	Dehydroepiandrosterone Sulfate	66-96	prolactin	Homo sapiens	58-61
6449151-1	1980	To clarify the controversy about the effect of prolactin (PRL) on dehydroepiandrosterone sulfate (DHEA-S), this study was undertaken to investigate the effects of alterations in plasma PRL on plasma DHEA-S concentrations in hyperprolactinemic women, as well as in normal male subjects.	Dehydroepiandrosterone Sulfate	66-96	sulfotransferase family 2A member 1	Homo sapiens	98-104
6256925-9	1980	In this experiment, there was a marked increase in DS secretion rate after the addition of ACTH and a smaller increase in cortisol secretion.	Dehydroepiandrosterone Sulfate	51-53	proopiomelanocortin	Homo sapiens	91-95
6162943-0	1980	Preparation and antigenic properties of dehydroepiandrosterone sulfate-bovine serum albumin conjugates having a linkage through the position in ring D. The preparation and antigenic properties of two different types of dehydroepiandrosterone sulfate-bovine serum albumin (BSA) conjugates in which the hapten is linked to the carrier protein through the C-17 or C-15 position have been described.	Dehydroepiandrosterone Sulfate	40-70	albumin	Oryctolagus cuniculus	78-91
6162943-0	1980	Preparation and antigenic properties of dehydroepiandrosterone sulfate-bovine serum albumin conjugates having a linkage through the position in ring D. The preparation and antigenic properties of two different types of dehydroepiandrosterone sulfate-bovine serum albumin (BSA) conjugates in which the hapten is linked to the carrier protein through the C-17 or C-15 position have been described.	Dehydroepiandrosterone Sulfate	219-249	albumin	Oryctolagus cuniculus	78-91
6246135-1	1980	ACTH-stimulated adrenal tissue of a human anencephalic fetus, when maintained in organ culture, secreted appreciable quantities of cortisol but little dehydroisoandrosterone sulfate or pregnenolone sulfate.	Dehydroepiandrosterone Sulfate	151-181	proopiomelanocortin	Homo sapiens	0-4
6446424-3	1980	(100 mg) injection of dehydroepiandrosterone sulphate (DHEA-S) in a series of twenty-six women with mid-trimester abortion.	Dehydroepiandrosterone Sulfate	22-53	sulfotransferase family 2A member 1	Homo sapiens	55-61
6930360-1	1980	Steroid sulfatase (STS) activities in female fibroblast strains are significantly higher than in male strains, as determined by cleavage of dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	140-170	steroid sulfatase	Homo sapiens	0-17
157360-0	1979	Intraamniotic or intravenous injection of dehydroepiandrosterone sulfate in midgestation: effect on prolactin level in maternal serum and amniotic fluid.	Dehydroepiandrosterone Sulfate	42-72	prolactin	Homo sapiens	100-109
157360-1	1979	The influence of dehydroepiandrosterone sulfate (DHEA-S) on PRL levels in maternal serum and amniotic fluid at midgestation was evaluated in a series of 32 women admitted for midtrimester abortion.	Dehydroepiandrosterone Sulfate	17-47	prolactin	Homo sapiens	60-63
156321-3	1979	A study was therefore undertaken to investigate the effect of 100 mg of intravenously administered dehydroepiandrosterone sulfate (DHEAS) on estradiol (E2), estriol (E3), and testosterone (T) serum levels.	Dehydroepiandrosterone Sulfate	99-129	sulfotransferase family 2A member 1	Homo sapiens	131-136
153779-1	1978	Although the clinical interpretation of its results varies greatly among perinatologists, the dehydroepiandrosterone sulfate (DHEA-S) loading test has become an integral part of fetal monitoring in many centres dealing with high-risk pregnancies.	Dehydroepiandrosterone Sulfate	94-124	sulfotransferase family 2A member 1	Homo sapiens	126-132
6448002-0	1980	Stable prolactin level after enhanced estradiol production following dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	69-99	prolactin	Homo sapiens	7-16
6448002-1	1980	To evaluate whether intravenous injection of dehydroepiandrosterone sulfate (DHEAS), by enhancing estradiol (E2) production, would stimulate prolactin (PRL) secretion in late pregnancy, maternal serum PRL was determined before and 1 to 5 hours after administration of 100 mg of DHEAS in a total of 41 women with normal or complicated late pregnancies (twin pregnancy, pre-eclampsia, intrahepatic cholestasis of pregnancy, diabetes).	Dehydroepiandrosterone Sulfate	45-75	sulfotransferase family 2A member 1	Homo sapiens	77-82
6448002-1	1980	To evaluate whether intravenous injection of dehydroepiandrosterone sulfate (DHEAS), by enhancing estradiol (E2) production, would stimulate prolactin (PRL) secretion in late pregnancy, maternal serum PRL was determined before and 1 to 5 hours after administration of 100 mg of DHEAS in a total of 41 women with normal or complicated late pregnancies (twin pregnancy, pre-eclampsia, intrahepatic cholestasis of pregnancy, diabetes).	Dehydroepiandrosterone Sulfate	45-75	prolactin	Homo sapiens	141-150
6448002-1	1980	To evaluate whether intravenous injection of dehydroepiandrosterone sulfate (DHEAS), by enhancing estradiol (E2) production, would stimulate prolactin (PRL) secretion in late pregnancy, maternal serum PRL was determined before and 1 to 5 hours after administration of 100 mg of DHEAS in a total of 41 women with normal or complicated late pregnancies (twin pregnancy, pre-eclampsia, intrahepatic cholestasis of pregnancy, diabetes).	Dehydroepiandrosterone Sulfate	45-75	prolactin	Homo sapiens	152-155
6448002-1	1980	To evaluate whether intravenous injection of dehydroepiandrosterone sulfate (DHEAS), by enhancing estradiol (E2) production, would stimulate prolactin (PRL) secretion in late pregnancy, maternal serum PRL was determined before and 1 to 5 hours after administration of 100 mg of DHEAS in a total of 41 women with normal or complicated late pregnancies (twin pregnancy, pre-eclampsia, intrahepatic cholestasis of pregnancy, diabetes).	Dehydroepiandrosterone Sulfate	45-75	prolactin	Homo sapiens	201-204
6448002-1	1980	To evaluate whether intravenous injection of dehydroepiandrosterone sulfate (DHEAS), by enhancing estradiol (E2) production, would stimulate prolactin (PRL) secretion in late pregnancy, maternal serum PRL was determined before and 1 to 5 hours after administration of 100 mg of DHEAS in a total of 41 women with normal or complicated late pregnancies (twin pregnancy, pre-eclampsia, intrahepatic cholestasis of pregnancy, diabetes).	Dehydroepiandrosterone Sulfate	45-75	sulfotransferase family 2A member 1	Homo sapiens	278-283
263313-5	1978	DHAS secretion by the fetal zone was also stimulated by ACTH.	Dehydroepiandrosterone Sulfate	0-4	proopiomelanocortin	Homo sapiens	56-60
263313-6	1978	These results indicate that the definitive and fetal zones of the human fetal adrenal gland at midgestation have the capacity to respond to ACTH with increased corticoid or DHAS secretion, respectively.	Dehydroepiandrosterone Sulfate	173-177	proopiomelanocortin	Homo sapiens	140-144
149950-1	1978	Simultaneous serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) and 17-hydroxyprogesterone (17-OHP) were compared with urinary 17-ketosteroid (17-KS) and pregnanetriol (PT) excretion during therapy in 18 prepubertal patients with the 21-hydroxylase deficiency form of congenital adrenal hyperplasia (CAH).	Dehydroepiandrosterone Sulfate	37-67	sulfotransferase family 2A member 1	Homo sapiens	69-75
162472-4	1978	A significant increase in DHAS production was observed in the presence of hCG.	Dehydroepiandrosterone Sulfate	26-30	hypertrichosis 2 (generalised, congenital)	Homo sapiens	74-77
162472-6	1978	In the presence of hCG (250 ng/ml), DHAS secretion increased significantly (P less than 0.01) over the controls to 116 +/- 12.0 at 120 min, and remained above the controls thereafter.	Dehydroepiandrosterone Sulfate	36-40	hypertrichosis 2 (generalised, congenital)	Homo sapiens	19-22
162472-7	1978	These results support the hypothesis that hCG is one of the regulators of DHAS production by the human fetal adrenal gland early in gestation.	Dehydroepiandrosterone Sulfate	74-78	hypertrichosis 2 (generalised, congenital)	Homo sapiens	42-45
162472-8	1978	As we found that ACTh stimulated DHAS secretion in a previous study and as there is indirect evidence for a role of ACTH in DHAS regulation late in pregnancy, these observations suggest dual regulation by hCG and ACTH early in pregnancy, and a possible transition to ACTH regulation of the fetal zone of the human fetal adrenal after midgestation.	Dehydroepiandrosterone Sulfate	33-37	proopiomelanocortin	Homo sapiens	17-21
162472-8	1978	As we found that ACTh stimulated DHAS secretion in a previous study and as there is indirect evidence for a role of ACTH in DHAS regulation late in pregnancy, these observations suggest dual regulation by hCG and ACTH early in pregnancy, and a possible transition to ACTH regulation of the fetal zone of the human fetal adrenal after midgestation.	Dehydroepiandrosterone Sulfate	124-128	proopiomelanocortin	Homo sapiens	116-120
208200-5	1978	Although not eliminating the possible existence of a specific fetal corticotrophin related to ACTH1-39, the data indicate that hACTH is capable of regulating steroidogenesis in the fetal zone which is primarily geared to the formation of dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	238-268	proopiomelanocortin	Homo sapiens	127-132
141976-3	1977	In the development of the "Western-environmental" or "adrenal" type, it is proposed that dehydroepiandrosterone sulphate (DHEAS), secreted by the adrenal, may be implicated.	Dehydroepiandrosterone Sulfate	89-120	sulfotransferase family 2A member 1	Homo sapiens	122-127
335574-4	1977	Basal plasma E2, E1, T, DHT, DHA and DHAS concentrations significantly correlated with the releasable pool of LH evoked by Gn-RH from the pituitary gonadotropes.	Dehydroepiandrosterone Sulfate	37-41	gonadotropin releasing hormone 1	Homo sapiens	123-128
126124-1	1975	A rapid radioimmunoassay for the determination of dehydroepiandrosterone sulphate (DHEA-S) in diluted human plasma is described.	Dehydroepiandrosterone Sulfate	50-81	sulfotransferase family 2A member 1	Homo sapiens	83-89
139414-2	1977	The hypertensive subjects, and to the greatest degree those of the low renin subgroup, excreted increased amounts of 16 beta-OH DHEA sulfate and glucuronide and lesser amounts of DHEA sulfate and glucuronide than the controls.	Dehydroepiandrosterone Sulfate	128-140	renin	Homo sapiens	71-76
139414-2	1977	The hypertensive subjects, and to the greatest degree those of the low renin subgroup, excreted increased amounts of 16 beta-OH DHEA sulfate and glucuronide and lesser amounts of DHEA sulfate and glucuronide than the controls.	Dehydroepiandrosterone Sulfate	179-191	renin	Homo sapiens	71-76
190843-2	1977	Oestrone formation from dehydroepiandrosterone (D), D-sulphate (DS) or 4-androstenedione (A) was less than or equal to 5% of oestradiol-17beta (Oe2) formation.	Dehydroepiandrosterone Sulfate	52-62	EBF transcription factor 3	Homo sapiens	144-147
132507-1	1976	Treatment of male guinea-pigs daily with an oral dose of 2 mg dehydroepiandrosterone (DHA) sulphate/100 g body weight for 2 weeks significantly reduced the glucose-6-phosphate dehydrogenase (G-6-PDH) activity of erythrocytes, liver, kidney and testis.	Dehydroepiandrosterone Sulfate	62-99	glucose-6-phosphate 1-dehydrogenase	Cavia porcellus	156-189
132507-1	1976	Treatment of male guinea-pigs daily with an oral dose of 2 mg dehydroepiandrosterone (DHA) sulphate/100 g body weight for 2 weeks significantly reduced the glucose-6-phosphate dehydrogenase (G-6-PDH) activity of erythrocytes, liver, kidney and testis.	Dehydroepiandrosterone Sulfate	62-99	glucose-6-phosphate 1-dehydrogenase	Cavia porcellus	191-198
129008-3	1976	In the present study, the metabolic clearance rate of dehydroisoandrosterone sulfate (MCRDS) decreased in normotensive gravidas during short-term studies utilizing angiotensin II-induced elevation of blood pressure.	Dehydroepiandrosterone Sulfate	54-84	angiotensinogen	Homo sapiens	164-178
133827-14	1975	(6) Increases in serum unconjugated E1, E2 and E3 after intravenous administration of DHAS in three pregnant women with a live anencephalic fetus were found.	Dehydroepiandrosterone Sulfate	86-90	small nucleolar RNA, H/ACA box 73A	Homo sapiens	36-49
4251986-2	1971	C19 and C18 steroids in plasma and skin eluates of acne patients before and after administration of dehydroepiandrosterone sulfate].	Dehydroepiandrosterone Sulfate	100-130	Bardet-Biedl syndrome 9	Homo sapiens	8-11
163457-4	1975	Since the contribution of the adrenal cortex to the peripheral levels of dehydroepiandrosterone sulfate (DHEA-S) is greater than 95% in premenopausal women, a plausible explanation for the marked drop observed in peripheral DHEA-S levels after menopause is that the ovary influences the steroidogenic activity of the adrenal cortex.	Dehydroepiandrosterone Sulfate	73-103	sulfotransferase family 2A member 1	Homo sapiens	105-111
163457-4	1975	Since the contribution of the adrenal cortex to the peripheral levels of dehydroepiandrosterone sulfate (DHEA-S) is greater than 95% in premenopausal women, a plausible explanation for the marked drop observed in peripheral DHEA-S levels after menopause is that the ovary influences the steroidogenic activity of the adrenal cortex.	Dehydroepiandrosterone Sulfate	73-103	sulfotransferase family 2A member 1	Homo sapiens	224-230
163841-2	1975	The inhibition of binding for E-2 and DHT by E-2, testosterone (T), DHT, dehydroepiandosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), androstendione (A) and 5-androstene-3beta, 17beta-diol (Adiol) was tested with the use of dextran-coated charcoal separation of bound and free E-2, respectively, and DHT.	Dehydroepiandrosterone Sulfate	103-133	cystatin 12, pseudogene	Homo sapiens	30-33
33647522-8	2021	For subtyping into adrenal or pituitary Cushing"s syndrome, dehydroepiandrosterone sulfate (DHEA-S) showed the highest AUROC (0.988), which was similar to that of plasma ACTH (0.994, P = 0.458).	Dehydroepiandrosterone Sulfate	60-90	sulfotransferase family 2A member 1	Homo sapiens	92-98
14489110-0	1962	Binding of dehydroepiandrosterone sulfate to serum albumin.	Dehydroepiandrosterone Sulfate	11-41	albumin	Homo sapiens	45-58
33508827-2	2021	Very few studies have assessed dehydroepiandrosterone sulphate (DHEA-S) in BD and its relation to cognitive functioning despite evidence showing its regulatory effects on glucocorticoid action.	Dehydroepiandrosterone Sulfate	31-62	sulfotransferase family 2A member 1	Homo sapiens	64-70
33485193-6	2021	The effect of IMPy and DETP on DHEAS and TT levels, respectively, was higher in subjects that carried the PON1 55MM genotype, while the effect of TCPy, IMPy, and DETP on thyroid hormone levels was higher in PON1 192QR/RR or 55MM genotype carriers.	Dehydroepiandrosterone Sulfate	31-36	paraoxonase 1	Homo sapiens	106-110
32643208-1	2021	BACKGROUND: Adrenarche involves maturation of the hypothalamic-pituitary-adrenal axis and increased production of dehydroepiandrosterone and its sulfate ester, dehydroepiandrosterone-sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	160-190	sulfotransferase family 2A member 1	Homo sapiens	192-198
33511622-3	2022	It was the aim of this study to test whether these constituents of herbal extracts are interacting with the uptake of estrone 3-sulfate, pregnenolone sulfate, and dehydroepiandrosterone sulfate mediated by the uptake transporters organic anion transporting polypeptide 2B1 (OATP2B1) or organic anion transporting polypeptide 1A2 (OATP1A2).	Dehydroepiandrosterone Sulfate	163-193	solute carrier organic anion transporter family member 2B1	Homo sapiens	230-272
33511622-3	2022	It was the aim of this study to test whether these constituents of herbal extracts are interacting with the uptake of estrone 3-sulfate, pregnenolone sulfate, and dehydroepiandrosterone sulfate mediated by the uptake transporters organic anion transporting polypeptide 2B1 (OATP2B1) or organic anion transporting polypeptide 1A2 (OATP1A2).	Dehydroepiandrosterone Sulfate	163-193	solute carrier organic anion transporter family member 2B1	Homo sapiens	274-281
33511622-3	2022	It was the aim of this study to test whether these constituents of herbal extracts are interacting with the uptake of estrone 3-sulfate, pregnenolone sulfate, and dehydroepiandrosterone sulfate mediated by the uptake transporters organic anion transporting polypeptide 2B1 (OATP2B1) or organic anion transporting polypeptide 1A2 (OATP1A2).	Dehydroepiandrosterone Sulfate	163-193	solute carrier organic anion transporter family member 1A2	Homo sapiens	286-328
33511622-3	2022	It was the aim of this study to test whether these constituents of herbal extracts are interacting with the uptake of estrone 3-sulfate, pregnenolone sulfate, and dehydroepiandrosterone sulfate mediated by the uptake transporters organic anion transporting polypeptide 2B1 (OATP2B1) or organic anion transporting polypeptide 1A2 (OATP1A2).	Dehydroepiandrosterone Sulfate	163-193	solute carrier organic anion transporter family member 1A2	Homo sapiens	330-337
33788012-2	2022	The decreased levels of dehydroepiandrosterone sulphate (DHEA-S) are associated with hyperlipidemia, atherosclerosis and obesity.	Dehydroepiandrosterone Sulfate	24-55	sulfotransferase family 2A member 1	Homo sapiens	57-63
33553553-1	2021	Objective: Dehydroepiandrosterone sulfate (DHEAs), a prohormone secreted by the adrenal gland, plays a role in the synthesis of sex hormones, namely, androgen and estrogen.	Dehydroepiandrosterone Sulfate	11-41	sulfotransferase family 2A member 1	Homo sapiens	43-48
32818652-10	2020	Presence of the haplotype abolished the DHEAS-transport function of OATP1B3-1B7.	Dehydroepiandrosterone Sulfate	40-45	solute carrier organic anion transporter family member 1B3	Homo sapiens	68-75
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Dehydroepiandrosterone Sulfate	173-178	interleukin 18	Homo sapiens	46-51
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Dehydroepiandrosterone Sulfate	173-178	interleukin 1 alpha	Homo sapiens	55-63
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Dehydroepiandrosterone Sulfate	304-309	interleukin 18	Homo sapiens	46-51
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Dehydroepiandrosterone Sulfate	304-309	interleukin 1 alpha	Homo sapiens	55-63
33039429-3	2020	We tested the immunoassay for cross reactivity with dehydroepiandrosterone sulfate (DHEA-S) and 17alpha-hydroxyprogesterone (17alpha-OHP).	Dehydroepiandrosterone Sulfate	52-82	sulfotransferase family 2A member 1	Homo sapiens	84-90
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Dehydroepiandrosterone Sulfate	159-171	interleukin 18	Homo sapiens	46-51
30905228-1	2020	PURPOSE: The aim of the present study was to determine how age-related decreases in serum dehydroepiandrosterone sulfate (DHEAS) levels affect various physiological processes.	Dehydroepiandrosterone Sulfate	90-120	sulfotransferase family 2A member 1	Homo sapiens	122-127
32928794-3	2020	The conversion of DHEAS into DHEA by steroid sulfatase (STS) may contribute to sustained intracrine androgen synthesis.	Dehydroepiandrosterone Sulfate	18-23	steroid sulfatase	Homo sapiens	37-54
32388228-0	2020	Associations between dehydroepiandrosterone sulphate (DHEAS) and cognitive function in 5,061 older men and women in the English Longitudinal Study of Ageing.	Dehydroepiandrosterone Sulfate	21-52	sulfotransferase family 2A member 1	Homo sapiens	54-59
32988141-1	2020	Objective: To evaluate the changes and diagnostic value of serum dehydroepiandrosterone sulfate (DHEAS) in Cushing"s syndrome (CS) with different etiologies.	Dehydroepiandrosterone Sulfate	65-95	sulfotransferase family 2A member 1	Homo sapiens	97-102
32758184-1	2020	BACKGROUND: A complex interaction between cortisol and dehydroepiandrosterone-sulphate (DHEA-S) is crucial in the stress system balance; several studies have reported increased cortisol levels during chronic stress and a weak counter-regulation by DHEA-S.	Dehydroepiandrosterone Sulfate	55-86	sulfotransferase family 2A member 1	Homo sapiens	88-94
32758184-1	2020	BACKGROUND: A complex interaction between cortisol and dehydroepiandrosterone-sulphate (DHEA-S) is crucial in the stress system balance; several studies have reported increased cortisol levels during chronic stress and a weak counter-regulation by DHEA-S.	Dehydroepiandrosterone Sulfate	55-86	sulfotransferase family 2A member 1	Homo sapiens	248-254
32410195-8	2020	Also, the enhanced nuclear localization of DAF-16 and consequently the overexpression of chaperone HSP-16.2 by hypoxia were significantly reduced in SS + DHEAS exposed worms.	Dehydroepiandrosterone Sulfate	154-159	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	43-49
32504913-8	2020	We collected anthropometrics and assayed saliva specimens for dehydroepiandrosterone-sulfate (DHEA-S) to assess adrenarcheal status.	Dehydroepiandrosterone Sulfate	62-92	sulfotransferase family 2A member 1	Homo sapiens	94-100
32921089-1	2020	Studies have yielded contradictory results concerning the association between dehydroepiandrosterone sulfate (DHEAS) and mortality in the elderly population.	Dehydroepiandrosterone Sulfate	78-108	sulfotransferase family 2A member 1	Homo sapiens	110-115
32824087-5	2020	We herein screened for ABCC11-inhibitory activities in 34 natural products derived from plants cultivated for human consumption using an in vitro assay system to measure the ABCC11-mediated transport of radiolabeled dehydroepiandrosterone sulfate (DHEA-S-an ABCC11 substrate).	Dehydroepiandrosterone Sulfate	216-246	ATP binding cassette subfamily C member 11	Homo sapiens	23-29
32824087-5	2020	We herein screened for ABCC11-inhibitory activities in 34 natural products derived from plants cultivated for human consumption using an in vitro assay system to measure the ABCC11-mediated transport of radiolabeled dehydroepiandrosterone sulfate (DHEA-S-an ABCC11 substrate).	Dehydroepiandrosterone Sulfate	216-246	ATP binding cassette subfamily C member 11	Homo sapiens	174-180
32824087-5	2020	We herein screened for ABCC11-inhibitory activities in 34 natural products derived from plants cultivated for human consumption using an in vitro assay system to measure the ABCC11-mediated transport of radiolabeled dehydroepiandrosterone sulfate (DHEA-S-an ABCC11 substrate).	Dehydroepiandrosterone Sulfate	216-246	ATP binding cassette subfamily C member 11	Homo sapiens	174-180
32388228-1	2020	Despite extensive observational and intervention research, the association between concentrations of dehydroepiandrosterone sulfate (DHEAS) and cognition at older ages remains unclear.	Dehydroepiandrosterone Sulfate	101-131	sulfotransferase family 2A member 1	Homo sapiens	133-138
31920957-5	2019	Results: AH outcome correlated negatively with dehydroepiandrosterone-sulfate (DHEAS) at 8 (r = -0.72), 10 (r = -0.79), and 12 years (r = -0.72); testosterone at 10 (r = -0.94), 12 (r = -0.70) and 14 years (r = -0.64); dihydrotestosterone (DHT) at 10 (r = -0.62) and 12 years; (r = -0.57) and AMH at 12 years (r = 0.62) of age.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-84
32629959-3	2020	This study is the first to examine not only the cross-sectional but also the longitudinal effects of PCB exposure on the stress hormones DHEAS and cortisol.	Dehydroepiandrosterone Sulfate	137-142	pyruvate carboxylase	Homo sapiens	101-104
32629959-9	2020	These results suggest a causal pathophysiological relationship between PCB exposure and DHEAS concentration, but not with cortisol.	Dehydroepiandrosterone Sulfate	88-93	pyruvate carboxylase	Homo sapiens	71-74
33634256-1	2021	Alterations in dehydroepiandrosterone sulfate (DHEAS) levels have been shown to affect the cardiovascular system.	Dehydroepiandrosterone Sulfate	15-45	sulfotransferase family 2A member 1	Homo sapiens	47-52
32148484-1	2020	Background: Increased dehydroepiandrosterone sulfate (DHEAS) levels have been reported in men with early-onset (<35 years) androgenetic alopecia (AGA).	Dehydroepiandrosterone Sulfate	22-52	sulfotransferase family 2A member 1	Homo sapiens	54-59
31760088-1	2020	It is generally assumed that circulating dehydroepiandrosterone sulfate (DHEAS) can be desulfated and further metabolized to estrogen, which is of concern for all patients with estrogen-responsive breast cancer.	Dehydroepiandrosterone Sulfate	41-71	sulfotransferase family 2A member 1	Homo sapiens	73-78
32517659-11	2020	DHEA-S concentration positively correlated with both serum albumin and BM.	Dehydroepiandrosterone Sulfate	0-6	albumin	Homo sapiens	59-66
32529179-2	2020	This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS).	Dehydroepiandrosterone Sulfate	38-68	sulfotransferase family 2A member 1	Homo sapiens	70-76
32435230-3	2020	Approximately 74% of DHEAS is hydrolyzed to DHEA by the steroid sulfatase (STS).	Dehydroepiandrosterone Sulfate	21-26	steroid sulfatase	Homo sapiens	56-73
31770749-1	2020	BACKGROUND AND AIM: Serum dehydroepiandrosterone sulfate (DHEA-S) is known to be lower in chronic kidney disease (CKD) patients and in those with cardiac disease, and correlates with a poor cardiovascular outcome.	Dehydroepiandrosterone Sulfate	26-56	sulfotransferase family 2A member 1	Homo sapiens	58-64
31472065-1	2019	Background Premature adrenarche (PA) is defined as the appearance of clinical signs of androgen action associated with levels of dehydroepiandrosterone sulfate (DHEAS) &gt;=40 mug/dL, before age 8 years in girls and 9 years in boys, without breast or testicular enlargement.	Dehydroepiandrosterone Sulfate	129-159	sulfotransferase family 2A member 1	Homo sapiens	161-166
31064233-9	2019	Serum NRG4 levels were positively correlated with body mass index (BMI); waist/hip ratio; HOMA-IR; and levels of triglycerides, hs-CRP, FBG, insulin, AMH, and dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	159-190	neuregulin 4	Homo sapiens	6-10
31468643-2	2019	Here, we used a nonhuman primate model to test the hypotheses that milk cortisol and dehydroepiandrosterone-sulfate (DHEAS) concentrations reflect maternal characteristics, and that changes in these hormones across lactation are associated with early postnatal growth rates.	Dehydroepiandrosterone Sulfate	85-115	sulfotransferase family 2A member 1	Homo sapiens	117-122
31161375-5	2019	Participants within higher dehydroepiandrosterone sulfate (DHEAS) and free testosterone (FT) tertiles were likely to be younger, have greater muscle mass, and have stronger hand grip strength.	Dehydroepiandrosterone Sulfate	27-57	sulfotransferase family 2A member 1	Homo sapiens	59-64
31561822-2	2019	BACKGROUND: The effect of dehydroepiandrosterone sulfate (DHEA-S) on fall risk in older age is still unclear, as is the effect of sex on any relationship between the two.	Dehydroepiandrosterone Sulfate	26-56	sulfotransferase family 2A member 1	Homo sapiens	58-64
31445893-2	2019	CYP3A7 has been demonstrated to metabolize two endogenous compounds that are known to be important in the growth and development of the fetus and neonate, namely dehydroepiandrosterone sulfate (DHEA-S) and all-trans retinoic acid (atRA).	Dehydroepiandrosterone Sulfate	162-192	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	0-6
31445893-2	2019	CYP3A7 has been demonstrated to metabolize two endogenous compounds that are known to be important in the growth and development of the fetus and neonate, namely dehydroepiandrosterone sulfate (DHEA-S) and all-trans retinoic acid (atRA).	Dehydroepiandrosterone Sulfate	194-200	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	0-6
31295971-2	2019	Measurement of testosterone is recommended in all of the current clinical guidelines but other steroids, such as androstenedione and dehydroepiandrosterone sulfate (DHEAS), have also been shown to be useful in diagnosing PCOS and may give additional information on metabolic risk.	Dehydroepiandrosterone Sulfate	133-163	sulfotransferase family 2A member 1	Homo sapiens	165-170
30536399-2	2019	Sex hormones have been documented to influence the development of SLE, in which women with SLE have low plasma level of dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	120-150	sulfotransferase family 2A member 1	Homo sapiens	152-157
31127008-6	2019	First, we screened a selection of OATP1B substrates for inhibition of OATP1B3-1B7-mediated transport of dehydroepiandrosterone sulfate and identified several inhibitors.	Dehydroepiandrosterone Sulfate	104-134	solute carrier organic anion transporter family member 1B3	Homo sapiens	70-77
31495080-1	2019	We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1).	Dehydroepiandrosterone Sulfate	54-84	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	216-221
31495080-1	2019	We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1).	Dehydroepiandrosterone Sulfate	86-91	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	216-221
31620295-0	2019	The association between serum dehydroepiandrosterone sulfate (DHEAS) levels and job-related stress among female nurses.	Dehydroepiandrosterone Sulfate	30-60	sulfotransferase family 2A member 1	Homo sapiens	62-67
31620295-1	2019	Background: Dehydroepiandrosterone sulfate (DHEAS) is an endogenous steroid hormone produced by the adrenal gland.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-49
31030988-1	2019	BACKGROUND: The neurosteroid dehydroepiandrosterone sulphate (DHEAS) activates the sigma-1 receptor, inhibits gamma-aminobutyric acid A (GABAA) and glycine receptors, and induces hyperalgesic effects.	Dehydroepiandrosterone Sulfate	29-60	sigma non-opioid intracellular receptor 1	Rattus norvegicus	83-99
31030988-1	2019	BACKGROUND: The neurosteroid dehydroepiandrosterone sulphate (DHEAS) activates the sigma-1 receptor, inhibits gamma-aminobutyric acid A (GABAA) and glycine receptors, and induces hyperalgesic effects.	Dehydroepiandrosterone Sulfate	62-67	sigma non-opioid intracellular receptor 1	Rattus norvegicus	83-99
31030988-7	2019	DHEAS suppressed the frequency of miniature inhibitory postsynaptic currents in a GABAA receptor- and sigma-1 receptor-dependent manner.	Dehydroepiandrosterone Sulfate	0-5	sigma non-opioid intracellular receptor 1	Rattus norvegicus	102-118
31211752-2	2019	Although it is known that the hypothalamic-pituitary-adrenal axis and cortisol are involved in the pathology of MDD, the association with dehydroepiandrosterone sulfate (DHEAS) remains unclear.	Dehydroepiandrosterone Sulfate	138-168	sulfotransferase family 2A member 1	Homo sapiens	170-175
30719548-1	2019	Analyses using the largest Korean cohort of adrenal incidentaloma (AI) revealed that subtle cortisol excess in premenopausal women and reduced dehydroepiandrosterone-sulfate (DHEA-S) in postmenopausal women and men are associated with bone mineral density (BMD) reduction in Asian patients with subclinical hypercortisolism (SH).	Dehydroepiandrosterone Sulfate	143-173	sulfotransferase family 2A member 1	Homo sapiens	175-181
30935894-13	2019	In conclusion, DHEA-S blocked stress-induced visceral changes via GABAA, NO, opioid, central dopamine D2 and peripheral CRF2 signaling.	Dehydroepiandrosterone Sulfate	15-21	corticotropin releasing hormone receptor 2	Rattus norvegicus	120-124
30550874-0	2019	Role of the Androgen Receptor Gene CAG Repeat Polymorphism on the Sequence of Pubertal Events and Adiposity in Girls with High Dehydroepiandrosterone Sulfate Level.	Dehydroepiandrosterone Sulfate	127-157	androgen receptor	Homo sapiens	12-29
30909017-2	2019	pACC is characterized by the usual overproduction of dehydroepiandrosterone sulfate (DHEAS), whose detection in serum or plasma can be effective to the early diagnosis of the disease.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	85-90
30612174-4	2019	Cortisol and dehydroepiandrosterone sulfate (DHEA-S) in the samples were extracted together, resolved on a C18-A column, and analyzed using tandem mass spectrometry.	Dehydroepiandrosterone Sulfate	13-43	sulfotransferase family 2A member 1	Homo sapiens	45-51
30685239-7	2019	Moreover, the uptake of the SLC probe substrate DHEAS was higher in 4-week than in 1-week Huh7 cultures.	Dehydroepiandrosterone Sulfate	48-53	MIR7-3 host gene	Homo sapiens	90-94
30807787-5	2019	DHEAS activation of androgen receptor (AR) and stimulation of PCa cell growth were STS-dependent.	Dehydroepiandrosterone Sulfate	0-5	androgen receptor	Homo sapiens	20-37
30807787-5	2019	DHEAS activation of androgen receptor (AR) and stimulation of PCa cell growth were STS-dependent.	Dehydroepiandrosterone Sulfate	0-5	androgen receptor	Homo sapiens	39-41
31031706-6	2019	Results: SPI decreased serum dehydroepiandrosterone sulfate (DHEAS) levels in both men and women (P &lt; 0.01), with decreased androstenedione (A4) (P &lt; 0.01) in women not observed in men (P &lt; 0.86).	Dehydroepiandrosterone Sulfate	29-59	chromogranin A	Homo sapiens	9-12
31031706-6	2019	Results: SPI decreased serum dehydroepiandrosterone sulfate (DHEAS) levels in both men and women (P &lt; 0.01), with decreased androstenedione (A4) (P &lt; 0.01) in women not observed in men (P &lt; 0.86).	Dehydroepiandrosterone Sulfate	61-66	chromogranin A	Homo sapiens	9-12
30733309-9	2019	In high-risk patients, a one-unit increment in log-transformed androstenediol (A5diol) and dehydroepiandrosterone-sulfate (DHEA-S) levels were linked to DFS with HR of 1.47 (P = 0.0017; q = 0.026) and 1.24 (P = 0.043; q = 0.323), respectively.	Dehydroepiandrosterone Sulfate	91-121	sulfotransferase family 2A member 1	Homo sapiens	123-129
30623167-1	2019	Low blood dehydroepiandrosterone sulfate (DHEAS) levels have strong positive associations with stroke and coronary heart disease.	Dehydroepiandrosterone Sulfate	10-40	sulfotransferase family 2A member 1	Homo sapiens	42-47
30864633-1	2019	OBJECTIVE: To assess the relationships between serum dehydroepiandrosterone sulfate (DHEA-S) levels and heart rate variability (HRV) among different age groups.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	85-91
30529136-6	2019	The girls with a mother with a positive history of PCOS had significantly higher AMH serum levels compared with girls with a mother with a negative history of PCOS (3.37 +- 1.72  ng/mL vs 2.70 +- 1.25 ng/mL; P &lt; .05) with no differences in testosterone, DHEAS, androstenedione, and sex hormone binding globulin.	Dehydroepiandrosterone Sulfate	257-262	anti-Mullerian hormone	Homo sapiens	81-84
30858786-1	2019	Introduction: It is known that serum dehydroepiandrosterone sulphate (DHEA-S) levels are low in patients with chronic idiopathic urticaria.	Dehydroepiandrosterone Sulfate	37-68	sulfotransferase family 2A member 1	Homo sapiens	70-76
29796990-0	2019	Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.	Dehydroepiandrosterone Sulfate	27-57	matrix metallopeptidase 9	Homo sapiens	91-117
29796990-0	2019	Neuroprotective Effects of Dehydroepiandrosterone Sulfate Through Inhibiting Expression of Matrix Metalloproteinase-9 from Bradykinin-Challenged Astroglia.	Dehydroepiandrosterone Sulfate	27-57	kininogen 1	Homo sapiens	123-133
29796990-1	2019	Dehydroepiandrosterone sulfate (DHEAS), one of the most important neuroactive steroids, is produced in the adrenals and the brain.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
30674304-4	2019	Highly elevated serum testosterone level with normal adrenal androgens such as dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS) and androstenedione is usually regarded as ovary origin.	Dehydroepiandrosterone Sulfate	110-140	sulfotransferase family 2A member 1	Homo sapiens	142-147
30481467-5	2019	Seven compounds and one fixed-dose combination (100 muM final concentration) inhibited OSTalpha/beta-mediated dehydroepiandrosterone sulfate (DHEAS) uptake by >25%.	Dehydroepiandrosterone Sulfate	110-140	solute carrier family 51 subunit alpha	Homo sapiens	87-100
30481467-5	2019	Seven compounds and one fixed-dose combination (100 muM final concentration) inhibited OSTalpha/beta-mediated dehydroepiandrosterone sulfate (DHEAS) uptake by >25%.	Dehydroepiandrosterone Sulfate	142-147	solute carrier family 51 subunit alpha	Homo sapiens	87-100
31461705-1	2019	OBJECTIVE: Dehydroepiandrosterone (DHEA) sulfotransferase (SULT2A1) converts DHEA to DHEA sulfate (DHEAS) which prevents bioactive androgen excess.	Dehydroepiandrosterone Sulfate	85-97	sulfotransferase family 2A member 1	Homo sapiens	59-66
31461705-1	2019	OBJECTIVE: Dehydroepiandrosterone (DHEA) sulfotransferase (SULT2A1) converts DHEA to DHEA sulfate (DHEAS) which prevents bioactive androgen excess.	Dehydroepiandrosterone Sulfate	85-97	sulfotransferase family 2A member 1	Homo sapiens	99-104
30275221-2	2018	The objective of this study was to investigate whether dehydroepiandrosterone sulfate (DHEA-S) predicts the effectiveness of abiraterone acetate.	Dehydroepiandrosterone Sulfate	55-85	sulfotransferase family 2A member 1	Homo sapiens	87-93
30137510-1	2018	Context: Adrenarche refers to the rise of dehydroepiandrosterone sulfate (DHEA-S) associated with the development of a functional adrenal zona reticularis.	Dehydroepiandrosterone Sulfate	42-72	sulfotransferase family 2A member 1	Homo sapiens	74-80
28945155-4	2018	For OAT7, high uptake ratios (versus mock transfected HEK293 cells) of 29.6 and 15.3 were obtained with E3S and DHEAS.	Dehydroepiandrosterone Sulfate	112-117	solute carrier family 22 member 9	Homo sapiens	4-8
29684479-1	2018	Although dehydroepiandrosterone sulfate (DHEAS) constitutes the most abundant steroid in humans, in-depth investigations of its effects are rather scarce.	Dehydroepiandrosterone Sulfate	9-39	sulfotransferase family 2A member 1	Homo sapiens	41-46
28945155-12	2018	However, measurement of OAT7 activity therein will prove more challenging, as high uptake rates are evident with E3S and DHEAS only and both sulfoconjugates are known to be substrates of organic anion transporting polypeptides.	Dehydroepiandrosterone Sulfate	121-126	solute carrier family 22 member 9	Homo sapiens	24-28
30223902-13	2018	Additionally, in the study group, the multivariate analysis showed that serum dehydroepiandrosterone-sulfate (DHEA-S) levels &lt; 180 mug/dl were significantly associated with a rate of retrieved oocytes &gt; 3 (OR = 5.92, 95% CI 1.48-23.26, p = 0.012).	Dehydroepiandrosterone Sulfate	78-108	sulfotransferase family 2A member 1	Homo sapiens	110-116
29420067-8	2018	Studies in the novel cell-based system showed rapid and linear OSTalpha/beta-mediated transport for all tested compounds: dehydroepiandrosterone sulfate, digoxin, estrone sulfate, and taurocholate.	Dehydroepiandrosterone Sulfate	122-152	solute carrier family 51 subunit alpha	Homo sapiens	63-71
29757399-1	2018	Context: Premature adrenarche (PA) has been associated with overweight and insulin resistance, but the associations of serum dehydroepiandrosterone sulfate (DHEAS) concentration with other cardiometabolic risk factors are uncertain.	Dehydroepiandrosterone Sulfate	125-155	sulfotransferase family 2A member 1	Homo sapiens	157-162
31089550-2	2018	The purpose of this study was to evaluate the association between body mass index (BMI) and serum dehydroepiandrosterone sulfate (DHEAS) level.	Dehydroepiandrosterone Sulfate	98-128	sulfotransferase family 2A member 1	Homo sapiens	130-135
29954925-1	2018	High oestradiol (E2) and low dehydroepiandrosterone-sulfate (DHEA-S) levels are risk factors for pulmonary arterial hypertension (PAH) in men, but whether sex hormones are related to PAH in women is unknown.Post-menopausal women aged &gt;=55 years with PAH were matched by age and body mass index to women without cardiovascular disease.	Dehydroepiandrosterone Sulfate	29-59	sulfotransferase family 2A member 1	Homo sapiens	61-67
29743239-3	2018	Human PAPSS2 mutations manifest with undetectable DHEA sulfate, androgen excess, and metabolic disease, suggesting that ubiquitous PAPSS1 cannot compensate for deficient PAPSS2 in supporting DHEA sulfation.	Dehydroepiandrosterone Sulfate	50-62	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	6-12
30186871-4	2018	In one-month-old infants from mothers subjected to constant light, plasma levels of cortisol and cortisol response to ACTH were twofold higher, whereas plasma levels of DHAS and DHAS response to ACTH were markedly reduced, compared to control conditions.	Dehydroepiandrosterone Sulfate	178-182	proopiomelanocortin	Homo sapiens	195-199
30186871-7	2018	Hence, at birth and at 10 months of age, there were differential effects in DHAS, cortisol production, and their response to ACTH.	Dehydroepiandrosterone Sulfate	76-80	proopiomelanocortin	Homo sapiens	125-129
28951227-2	2018	SOAT substrates identified so far include dehydroepiandrosterone sulfate, 16alpha-hydroxydehydroepiandrosterone sulfate, estrone-3-sulfate, pregnenolone sulfate, 17beta-estradiol-3-sulfate, and androstenediol sulfate.	Dehydroepiandrosterone Sulfate	42-72	solute carrier family 10 member 6	Homo sapiens	0-4
30090723-10	2018	Lower levels of free testosterone and DHEAS were found in cases of severe immunosuppression with a statistically significant correlation with CD4 counts.	Dehydroepiandrosterone Sulfate	38-43	CD4 molecule	Homo sapiens	142-145
28744698-1	2018	BACKGROUND: The purpose of this study was to assess the predictive value of basal serum testosterone (T) and dehydroepiandrosterone sulfate (DHEAS) levels during follicular phase for ovarian response and outcome in intracytoplasmic sperm injection (ICSI) cycles of women with diminished ovarian reserve.	Dehydroepiandrosterone Sulfate	109-139	sulfotransferase family 2A member 1	Homo sapiens	141-146
29695968-8	2018	Furthermore, a role of the organic solute transporter OSTalpha-OSTbeta (SLC51A/B) in brain DHEAS/PregS homeostasis has been proposed.	Dehydroepiandrosterone Sulfate	91-96	solute carrier family 51 subunit alpha	Homo sapiens	72-80
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	37-67	Rous sarcoma oncogene	Mus musculus	91-94
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	37-67	v-raf-leukemia viral oncogene 1	Mus musculus	99-104
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	37-67	mitogen-activated protein kinase 3	Mus musculus	105-111
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	37-67	cAMP responsive element binding protein 1	Mus musculus	112-116
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	37-67	activating transcription factor 1	Mus musculus	117-122
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	69-74	Rous sarcoma oncogene	Mus musculus	91-94
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	69-74	v-raf-leukemia viral oncogene 1	Mus musculus	99-104
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	69-74	mitogen-activated protein kinase 3	Mus musculus	105-111
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	69-74	cAMP responsive element binding protein 1	Mus musculus	112-116
29017935-1	2018	In the spermatogenic cell line GC-2, dehydroepiandrosterone sulfate (DHEAS), activates the Src/Ras/c-Raf/Erk1/2/CREB(ATF-1) signaling cascade.	Dehydroepiandrosterone Sulfate	69-74	activating transcription factor 1	Mus musculus	117-122
29017935-2	2018	Since DHEAS is present in the gonads, and since spermatogenesis and maturation of spermatogonia to haploid spermatozoa requires activation of Erk1/2, the triggering of these signaling events by DHEAS might have physiological relevance.	Dehydroepiandrosterone Sulfate	194-199	mitogen-activated protein kinase 3	Mus musculus	142-148
29017935-3	2018	In the Sertoli cell line TM4, DHEAS-induces activation of Erk1/2, CREB, and ATF-1, stimulates expression of claudin-3 and claudin-5 and augments transepithelial resistance, indicating the formation of tight junctions between adjacent Sertoli cells.	Dehydroepiandrosterone Sulfate	30-35	mitogen-activated protein kinase 3	Mus musculus	58-64
29017935-3	2018	In the Sertoli cell line TM4, DHEAS-induces activation of Erk1/2, CREB, and ATF-1, stimulates expression of claudin-3 and claudin-5 and augments transepithelial resistance, indicating the formation of tight junctions between adjacent Sertoli cells.	Dehydroepiandrosterone Sulfate	30-35	cAMP responsive element binding protein 1	Mus musculus	66-70
29017935-3	2018	In the Sertoli cell line TM4, DHEAS-induces activation of Erk1/2, CREB, and ATF-1, stimulates expression of claudin-3 and claudin-5 and augments transepithelial resistance, indicating the formation of tight junctions between adjacent Sertoli cells.	Dehydroepiandrosterone Sulfate	30-35	activating transcription factor 1	Mus musculus	76-81
29017935-3	2018	In the Sertoli cell line TM4, DHEAS-induces activation of Erk1/2, CREB, and ATF-1, stimulates expression of claudin-3 and claudin-5 and augments transepithelial resistance, indicating the formation of tight junctions between adjacent Sertoli cells.	Dehydroepiandrosterone Sulfate	30-35	claudin 3	Mus musculus	108-117
29017935-3	2018	In the Sertoli cell line TM4, DHEAS-induces activation of Erk1/2, CREB, and ATF-1, stimulates expression of claudin-3 and claudin-5 and augments transepithelial resistance, indicating the formation of tight junctions between adjacent Sertoli cells.	Dehydroepiandrosterone Sulfate	30-35	claudin 5	Mus musculus	122-131
29017935-5	2018	In bEnd.3 brain-derived endothelial cells, DHEAS stimulates the expression of zonula occludens-1 and claudin-3 and promotes tight junction formation between neighboring cells, which at the blood-brain barrier protects the brain from harmful factors and cells.	Dehydroepiandrosterone Sulfate	43-48	claudin 3	Mus musculus	101-110
29360806-7	2018	Muscle mass, BMI SD score (SDS), %BF, and serum dehydroepiandrosterone sulfate (DHEAS) concentration were the strongest predictors of high BMD in mid-childhood.ConclusionSGA-born children had lower BMD in mid-childhood compared with AGA- and LGA-born ones.	Dehydroepiandrosterone Sulfate	48-78	sulfotransferase family 2A member 1	Homo sapiens	80-85
28328386-1	2018	The literature indicates that the plasma cortisol-to-dehydroepiandrosterone-sulfate (DHEA-S) ratio is a marker of health status after menopause, when a decline in both estrogen and DHEA-S and an increase in cortisol occur.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	85-91
28328386-1	2018	The literature indicates that the plasma cortisol-to-dehydroepiandrosterone-sulfate (DHEA-S) ratio is a marker of health status after menopause, when a decline in both estrogen and DHEA-S and an increase in cortisol occur.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	181-187
28903616-1	2018	The aim of this study was to determine the effect of hormone replacement therapy (HRT) on changes in circulating dehydroepiandrosterone-sulphate (DHEA-S) with focus on the relationship between oestrogen level and change in DHEA-S.	Dehydroepiandrosterone Sulfate	113-144	sulfotransferase family 2A member 1	Homo sapiens	146-152
29068242-6	2018	There was also a strong trend for a higher DHEAS among patients with lower insulin resistance by homeostatic model assessment (HOMA-IR&lt; 2.3) (p = .06).While the total testosterone (p = .044) and SHBG (p = .007) were found to be lower in the more insulin-resistant group (HOMA-IR &gt;= 2.3), the free testosterone levels were similar.	Dehydroepiandrosterone Sulfate	43-48	sex hormone binding globulin	Homo sapiens	198-202
29068242-6	2018	There was also a strong trend for a higher DHEAS among patients with lower insulin resistance by homeostatic model assessment (HOMA-IR&lt; 2.3) (p = .06).While the total testosterone (p = .044) and SHBG (p = .007) were found to be lower in the more insulin-resistant group (HOMA-IR &gt;= 2.3), the free testosterone levels were similar.	Dehydroepiandrosterone Sulfate	43-48	insulin	Homo sapiens	75-82
29091323-1	2018	Recently, an inverse association between serum levels of dehydroepiandrosterone sulphate (DHEA-S) and liver fibrosis in patients with nonalcoholic fatty liver disease was described, and it was postulated that dehydroepiandrosterone (DHEA) has antifibrotic effects.	Dehydroepiandrosterone Sulfate	57-88	sulfotransferase family 2A member 1	Homo sapiens	90-96
29226590-3	2018	This cross-sectional study examines dehydroepiandrosterone sulfate (DHEAS) production in relation to age, sex, ethnicity, and cortisol concentrations, as well as average age of adrenarche, among Aka and Ngandu children of the Central African Republic and Sidama children of Ethiopia.	Dehydroepiandrosterone Sulfate	36-66	sulfotransferase family 2A member 1	Homo sapiens	68-73
29248594-11	2018	Overexpression of LST-3TM12 was associated with enhanced cellular accumulation of dehydroepiandrosterone sulfate (Vmax 300.2 pmol mg-1 min-1; Km 34.2 microm) and estradiol 17beta-glucuronide (Vmax 29.9 mol mg-1 min-1 and Km 32.8 microM).	Dehydroepiandrosterone Sulfate	82-112	solute carrier organic anion transporter family member 1B7 (putative)	Homo sapiens	18-27
29248594-11	2018	Overexpression of LST-3TM12 was associated with enhanced cellular accumulation of dehydroepiandrosterone sulfate (Vmax 300.2 pmol mg-1 min-1; Km 34.2 microm) and estradiol 17beta-glucuronide (Vmax 29.9 mol mg-1 min-1 and Km 32.8 microM).	Dehydroepiandrosterone Sulfate	82-112	CD59 molecule (CD59 blood group)	Homo sapiens	135-140
29101069-10	2018	The rs9926289 FTO variant had a strong association with serum apelin and dehydroepiandrosterone-sulfate levels (P=0.04 and P=0.03, respectively) among SNPs.	Dehydroepiandrosterone Sulfate	73-103	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	14-17
28712091-7	2018	The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5, SULT2A1, HHEX, and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients, but not in controls.	Dehydroepiandrosterone Sulfate	55-60	zinc finger with KRAB and SCAN domains 5	Homo sapiens	74-81
28712091-7	2018	The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5, SULT2A1, HHEX, and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients, but not in controls.	Dehydroepiandrosterone Sulfate	55-60	sulfotransferase family 2A member 1	Homo sapiens	83-90
28712091-7	2018	The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5, SULT2A1, HHEX, and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients, but not in controls.	Dehydroepiandrosterone Sulfate	55-60	hematopoietically expressed homeobox	Homo sapiens	92-96
28712091-7	2018	The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5, SULT2A1, HHEX, and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients, but not in controls.	Dehydroepiandrosterone Sulfate	55-60	actin related protein 2/3 complex subunit 1A	Homo sapiens	102-108
28712091-7	2018	The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5, SULT2A1, HHEX, and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients, but not in controls.	Dehydroepiandrosterone Sulfate	163-168	zinc finger with KRAB and SCAN domains 5	Homo sapiens	74-81
28712091-7	2018	The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5, SULT2A1, HHEX, and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients, but not in controls.	Dehydroepiandrosterone Sulfate	163-168	sulfotransferase family 2A member 1	Homo sapiens	83-90
28712091-7	2018	The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5, SULT2A1, HHEX, and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients, but not in controls.	Dehydroepiandrosterone Sulfate	163-168	hematopoietically expressed homeobox	Homo sapiens	92-96
28712091-7	2018	The cumulative number of alleles associated with lower DHEAS within genes ZKSCAN5, SULT2A1, HHEX, and ARPC1A present in each individual negatively correlated with DHEAS levels in RA patients, but not in controls.	Dehydroepiandrosterone Sulfate	163-168	actin related protein 2/3 complex subunit 1A	Homo sapiens	102-108
28712091-8	2018	Linear regression analysis showed significant effect of polymorphisms in genes ZKSCAN5 and ARPC1A on serum DHEAS levels in female RA patients but not in the control group.	Dehydroepiandrosterone Sulfate	107-112	zinc finger with KRAB and SCAN domains 5	Homo sapiens	79-86
28712091-8	2018	Linear regression analysis showed significant effect of polymorphisms in genes ZKSCAN5 and ARPC1A on serum DHEAS levels in female RA patients but not in the control group.	Dehydroepiandrosterone Sulfate	107-112	actin related protein 2/3 complex subunit 1A	Homo sapiens	91-97
30029734-3	2018	DHEA and DHEA-sulfate (DHEA-S) have been reported to increase not only insulin secretion of the pancreas but also insulin sensitivity of the liver, adipose tissue, and muscle.	Dehydroepiandrosterone Sulfate	9-21	insulin	Homo sapiens	71-78
30029737-2	2018	Among them, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) also do modulate emotional processing and may have mood enhancement effects.	Dehydroepiandrosterone Sulfate	46-76	sulfotransferase family 2A member 1	Homo sapiens	78-83
29281066-1	2017	Background: The serum level of dehydroepiandrosterone sulphate (DHEA-S) has been suggested as a biological marker of stress.	Dehydroepiandrosterone Sulfate	31-62	sulfotransferase family 2A member 1	Homo sapiens	64-70
28911133-10	2017	The production of dehydroepiandrosterone sulfate (DHEAS) from HFA cells after kisspeptin treatment, alone or in combination with adrenocorticotropic hormone or corticotropin-releasing hormone.	Dehydroepiandrosterone Sulfate	18-48	corticotropin releasing hormone	Homo sapiens	160-191
28771887-6	2017	ACSL3 overexpression led to upregulation of several genes such as aldo-keto reductase 1C3 (AKR1C3) involved in steroidogenesis, which utilizes adrenal androgen dehydroepiandrosterone sulfate (DHEAS) as substrate, and downregulated androgen-inactivating enzyme UDP-glucuronosyltransferase 2 (UGT2B).	Dehydroepiandrosterone Sulfate	192-197	acyl-CoA synthetase long chain family member 3	Homo sapiens	0-5
28771887-6	2017	ACSL3 overexpression led to upregulation of several genes such as aldo-keto reductase 1C3 (AKR1C3) involved in steroidogenesis, which utilizes adrenal androgen dehydroepiandrosterone sulfate (DHEAS) as substrate, and downregulated androgen-inactivating enzyme UDP-glucuronosyltransferase 2 (UGT2B).	Dehydroepiandrosterone Sulfate	192-197	aldo-keto reductase family 1 member C3	Homo sapiens	66-89
28771887-6	2017	ACSL3 overexpression led to upregulation of several genes such as aldo-keto reductase 1C3 (AKR1C3) involved in steroidogenesis, which utilizes adrenal androgen dehydroepiandrosterone sulfate (DHEAS) as substrate, and downregulated androgen-inactivating enzyme UDP-glucuronosyltransferase 2 (UGT2B).	Dehydroepiandrosterone Sulfate	192-197	aldo-keto reductase family 1 member C3	Homo sapiens	91-97
28771887-7	2017	Exposure to DHEAS significantly increased testosterone levels and cell proliferative response in ACSL3-overexpressing cells when compared to that in control cells.	Dehydroepiandrosterone Sulfate	12-17	acyl-CoA synthetase long chain family member 3	Homo sapiens	97-102
28771887-11	2017	These findings suggest that ACSL3 contributes to the growth of CRPC through intratumoral steroidogenesis (i.e. promoting androgen synthesis from DHEAS and preventing the catabolism of active androgens).	Dehydroepiandrosterone Sulfate	145-150	acyl-CoA synthetase long chain family member 3	Homo sapiens	28-33
28911133-10	2017	The production of dehydroepiandrosterone sulfate (DHEAS) from HFA cells after kisspeptin treatment, alone or in combination with adrenocorticotropic hormone or corticotropin-releasing hormone.	Dehydroepiandrosterone Sulfate	50-55	corticotropin releasing hormone	Homo sapiens	160-191
27910716-6	2017	Morning serum cortisol was normal but significantly higher in patients, while dehydroepiandrosterone sulfate (DHEAS) to cortisol ratio, leptin and vitamin D were significantly lower in patients than controls.	Dehydroepiandrosterone Sulfate	78-108	sulfotransferase family 2A member 1	Homo sapiens	110-115
28810889-2	2017	Dehydroepiandrosterone sulfate (DHEAS) is a corticotropin-dependent adrenal androgen, which has immunostimulating and antiglucocorticoid effects.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
28419081-1	2017	BackgroundChildren born small for gestational age (SGA) have higher serum dehydroepiandrosterone sulfate (DHEAS) concentrations than children born appropriate for gestational age (AGA).	Dehydroepiandrosterone Sulfate	74-104	sulfotransferase family 2A member 1	Homo sapiens	106-111
28229260-0	2017	Dehydroepiandrosterone-sulfate (DHEA-S), sex, and age in zoo-housed western lowland gorillas (Gorilla gorilla gorilla).	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-38
28977889-1	2017	Steroid sulfatase (STS) catalyzes the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) to their unconjugated biologically active forms.	Dehydroepiandrosterone Sulfate	72-102	steroid sulfatase	Homo sapiens	0-17
28977889-1	2017	Steroid sulfatase (STS) catalyzes the hydrolysis of estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) to their unconjugated biologically active forms.	Dehydroepiandrosterone Sulfate	104-109	steroid sulfatase	Homo sapiens	0-17
27658887-1	2017	BACKGROUND: Dehydroepiandrosterone sulphate (DHEAS), the most plentiful circulating adrenal hormone, may be considered as a marker of the onset of adrenarche and is involved in pubertal development and metabolic disorders.	Dehydroepiandrosterone Sulfate	12-43	sulfotransferase family 2A member 1	Homo sapiens	45-50
28690989-8	2017	Serum dehydroepiandrosterone sulfate (DHEA-S) levels were significantly higher in subjects with dBACA&gt;1 compared to those with dBACA&lt;=1 (104.3+-62.2 vs. 59.6+-61.0, P=0.014).	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-44
28652501-2	2017	Overactivation of this axis leads to altered blood levels of cortisol and dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	74-104	sulfotransferase family 2A member 1	Homo sapiens	106-112
28319688-1	2017	BACKGROUND: In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders.	Dehydroepiandrosterone Sulfate	107-137	sulfotransferase family 2A member 1	Homo sapiens	139-145
28029519-13	2017	The patients in remission had a greater decrease in BMI after treatment and lower dehydroepiandrosterone sulfate (DHEAS) levels before treatment, compared with the recurrent group (both p &lt; 0.05).	Dehydroepiandrosterone Sulfate	82-112	sulfotransferase family 2A member 1	Homo sapiens	114-119
28495656-3	2017	Here we show that physiological concentrations of dehydroepiandrosterone sulfate (DHEAS) stimulate the expression of the TJ proteins zonula occludens-1 (ZO-1) and claudin-3 in the brain-derived endothelial cell line bEnd.3 and promote TJ formation between neighbouring cells, demonstrated by augmented transendothelial resistance across cell monolayers.	Dehydroepiandrosterone Sulfate	50-80	sulfotransferase family 2A member 1	Homo sapiens	82-87
28495656-3	2017	Here we show that physiological concentrations of dehydroepiandrosterone sulfate (DHEAS) stimulate the expression of the TJ proteins zonula occludens-1 (ZO-1) and claudin-3 in the brain-derived endothelial cell line bEnd.3 and promote TJ formation between neighbouring cells, demonstrated by augmented transendothelial resistance across cell monolayers.	Dehydroepiandrosterone Sulfate	50-80	tight junction protein 1	Homo sapiens	133-151
28495656-3	2017	Here we show that physiological concentrations of dehydroepiandrosterone sulfate (DHEAS) stimulate the expression of the TJ proteins zonula occludens-1 (ZO-1) and claudin-3 in the brain-derived endothelial cell line bEnd.3 and promote TJ formation between neighbouring cells, demonstrated by augmented transendothelial resistance across cell monolayers.	Dehydroepiandrosterone Sulfate	50-80	tight junction protein 1	Homo sapiens	153-157
28553251-3	2017	Addison"s disease results in deficiency of dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	77-89	sulfotransferase family 2A member 1	Homo sapiens	91-97
28476876-1	2017	BACKGROUND: The aim of the present study was to estimate the impact of dehydroepiandrosterone sulfate (DHEAS) on the prognosis of patients with cardiovascular disease by performing a systematic review and meta-analysis.	Dehydroepiandrosterone Sulfate	71-101	sulfotransferase family 2A member 1	Homo sapiens	103-108
28190756-6	2017	The OATP2B1-mediated theaflavin uptake was inhibited by known OATP2B1 substrates such as E3S, bromsulphthalein (BSP), dehydroepiandrosterone-3-sulfate (DHEAS), and fluvastatin.	Dehydroepiandrosterone Sulfate	118-150	solute carrier organic anion transporter family member 2B1	Homo sapiens	4-11
28190756-6	2017	The OATP2B1-mediated theaflavin uptake was inhibited by known OATP2B1 substrates such as E3S, bromsulphthalein (BSP), dehydroepiandrosterone-3-sulfate (DHEAS), and fluvastatin.	Dehydroepiandrosterone Sulfate	152-157	solute carrier organic anion transporter family member 2B1	Homo sapiens	4-11
28190756-6	2017	The OATP2B1-mediated theaflavin uptake was inhibited by known OATP2B1 substrates such as E3S, bromsulphthalein (BSP), dehydroepiandrosterone-3-sulfate (DHEAS), and fluvastatin.	Dehydroepiandrosterone Sulfate	152-157	solute carrier organic anion transporter family member 2B1	Homo sapiens	62-69
27914864-1	2017	OBJECTIVES: Dysregulation of the neuroendocrine system including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and pregnenolone may play a role in the pathophysiology of bipolar II disorder (BP-II).	Dehydroepiandrosterone Sulfate	96-126	sulfotransferase family 2A member 1	Homo sapiens	128-134
27941768-7	2017	Compared with controls, free testosterone (free T) and dehydroepiandrosterone sulfate (DHEAS) levels were lower in both the alloHCT group and GC groups; P&lt;0.0001 and P&lt;0.05, respectively.	Dehydroepiandrosterone Sulfate	55-85	sulfotransferase family 2A member 1	Homo sapiens	87-92
27797672-3	2017	Objective: To determine whether low basal dehydroepiandrosterone sulfate (DHEAS) is a sensitive and specific screening test for SH in AI.	Dehydroepiandrosterone Sulfate	42-72	sulfotransferase family 2A member 1	Homo sapiens	74-79
28207286-6	2017	Linear responses in wide range of concentrations and LOQs ranging from 10 (dehydroepiandrosterone 3-sulfate) to 40 pg ml-1 (dehydroepiandrosterone) were obtained in &lt;9 min.	Dehydroepiandrosterone Sulfate	75-107	TARBP2 subunit of RISC loading complex	Homo sapiens	53-57
27923285-1	2017	This study evaluated maternal serum levels of dehydroepiandrosterone sulphate (DHEAS) in spontaneous labour and its association with successful labour at term.	Dehydroepiandrosterone Sulfate	46-77	sulfotransferase family 2A member 1	Homo sapiens	79-84
28245188-7	2017	AMH levels showed a significant negative correlation with luteinizing hormone (LH), free testosterone and dehydroepiandrosterone sulphate (DHEAS) levels in the PT group.	Dehydroepiandrosterone Sulfate	106-137	anti-Mullerian hormone	Homo sapiens	0-3
28245188-7	2017	AMH levels showed a significant negative correlation with luteinizing hormone (LH), free testosterone and dehydroepiandrosterone sulphate (DHEAS) levels in the PT group.	Dehydroepiandrosterone Sulfate	139-144	anti-Mullerian hormone	Homo sapiens	0-3
28326299-0	2017	The Association between Dehydroepiandrosterone Sulfate (DHEA-S) and Bone Mineral Density in Korean Men and Women.	Dehydroepiandrosterone Sulfate	24-54	sulfotransferase family 2A member 1	Homo sapiens	56-62
28326299-1	2017	BACKGROUND: The relationship between dehydroepiandrosterone sulfate (DHEA-S) and bone mineral density (BMD) is controversial.	Dehydroepiandrosterone Sulfate	37-67	sulfotransferase family 2A member 1	Homo sapiens	69-75
27907849-2	2017	Dehydroepiandrosterone-sulfate (DHEAS) is an adrenal androgen commonly used as a marker of HPA function.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
29067249-1	2017	OBJECTIVE: To evaluate the relationship between age- and gender-adjusted dehydroepiandrosterone sulfate (DHEA-S) levels and low-dose adrenocorticotropic hormone (ACTH) stimulation in assessing the integrity of the hypothalamic-pituitary-adrenal (HPA) axis, in patients who were at risk of HPA insufficiency, including those currently being treated with glucocorticoids.	Dehydroepiandrosterone Sulfate	73-103	sulfotransferase family 2A member 1	Homo sapiens	105-111
29067249-1	2017	OBJECTIVE: To evaluate the relationship between age- and gender-adjusted dehydroepiandrosterone sulfate (DHEA-S) levels and low-dose adrenocorticotropic hormone (ACTH) stimulation in assessing the integrity of the hypothalamic-pituitary-adrenal (HPA) axis, in patients who were at risk of HPA insufficiency, including those currently being treated with glucocorticoids.	Dehydroepiandrosterone Sulfate	73-103	proopiomelanocortin	Homo sapiens	133-160
27501065-1	2016	OBJECTIVES: The aims of our study were to (i) investigate the association between rotating night shift work and blood concentrations of estradiol, testosterone and dehydroepiandrosterone sulfate (DHEAS) and (2) evaluate the role of their non-occupational determinants.	Dehydroepiandrosterone Sulfate	164-194	sulfotransferase family 2A member 1	Homo sapiens	196-201
28201960-1	2017	BACKGROUND: Low dehydroepiandrosterone sulfate (DHEAS) levels and a high cortisol/ DHEAS ratio are associated with higher mortality in elderly, dialyzed, and immunocompromised patients.	Dehydroepiandrosterone Sulfate	16-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
27623070-1	2016	CONTEXT: Adrenal production of dehydroepiandrosterone sulfate (DHEA-S) increases throughout childhood owing to expansion of the zona reticularis (ZR).	Dehydroepiandrosterone Sulfate	31-61	sulfotransferase family 2A member 1	Homo sapiens	63-69
26898983-2	2016	Although osteoarthritis (OA) and low levels of dehydroepiandrosterone sulfate (DHEAS) are common in the elderly, no studies on human beings are available concerning the possible relationship between them.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-84
27030299-8	2016	Dehydroepiandrosterone sulfate (DHEAS) showed no correlation with any case of PV, however it decreased significantly with age and had a correlation with alopecia.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
28528334-3	2017	Comparing patterns of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) may be especially relevant for understanding whether the childhood stage of growth and development is unique to humans and perhaps other apes.	Dehydroepiandrosterone Sulfate	56-68	sulfotransferase family 2A member 1	Homo sapiens	70-75
27797446-4	2017	Dehydroepiandrosterone sulfate levels were inversely associated with thrombin generation.	Dehydroepiandrosterone Sulfate	0-30	coagulation factor II, thrombin	Homo sapiens	69-77
27797446-13	2017	Contrary to hypotheses, higher DHEAS levels were associated with differences in TG peak and ETP that suggest less generation of thrombin.	Dehydroepiandrosterone Sulfate	31-36	coagulation factor II, thrombin	Homo sapiens	128-136
29333273-1	2017	Background: Previous reports have noted that dehydroepiandrosterone-sulfate (DHEAS) increases prior to the final menstrual period (FMP) and remains stable beyond the FMP.	Dehydroepiandrosterone Sulfate	45-75	sulfotransferase family 2A member 1	Homo sapiens	77-82
26752270-1	2016	BACKGROUND: The aim of this study was to determine the relationship of the salivary levels of dehydroepiandrosterone sulfate (DHEA-S) and cortisol with factors related to depression and anxiety in patients with hyperemesis gravidarum (HG).	Dehydroepiandrosterone Sulfate	94-124	sulfotransferase family 2A member 1	Homo sapiens	126-132
27465716-11	2016	AMH was inversely correlated with age in both groups, and directly correlated with testosterone and dehydroepiandrosterone sulfate only in DS women.	Dehydroepiandrosterone Sulfate	100-130	anti-Mullerian hormone	Homo sapiens	0-3
27033324-3	2016	More than 100 compounds of different molecular structures were screened for inhibition of the SOAT-mediated transport of dehydroepiandrosterone sulfate in stably transfected SOAT-HEK293 cells.	Dehydroepiandrosterone Sulfate	121-151	solute carrier family 10 member 6	Homo sapiens	94-98
27532919-17	2016	One observational study found lower, but still normal, dehydroepiandrosterone sulfate concentrations in statin-treated males with FH at 10-year follow-up.	Dehydroepiandrosterone Sulfate	55-85	low density lipoprotein receptor	Homo sapiens	130-132
27272182-10	2016	DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.	Dehydroepiandrosterone Sulfate	0-5	interleukin 6	Homo sapiens	58-62
30112477-1	2016	Objective: The purpose of this study was to find out whether blood spot Dehydroepiandrosterone Sulfate (DHEAs) levels can be used as Skeletal Maturity Indicators (SMI) by correlating them to hand-wrist maturation stages.	Dehydroepiandrosterone Sulfate	72-102	sulfotransferase family 2A member 1	Homo sapiens	104-109
27486349-9	2016	The previously suppressed ACTH increased to above normal range accompanied by an increase in dehydroepiandrosterone sulfate levels, indicating recovery of the HPA axis and atrophic contralateral adrenal gland.	Dehydroepiandrosterone Sulfate	93-123	proopiomelanocortin	Homo sapiens	26-30
27222435-3	2016	Accumulating evidence indicates that the Abeta-induced imbalance of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) in the brain plays an important role in the AD pathogenesis and progression.	Dehydroepiandrosterone Sulfate	102-132	amyloid beta precursor protein	Homo sapiens	41-46
27222435-3	2016	Accumulating evidence indicates that the Abeta-induced imbalance of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) in the brain plays an important role in the AD pathogenesis and progression.	Dehydroepiandrosterone Sulfate	134-139	amyloid beta precursor protein	Homo sapiens	41-46
27222435-7	2016	These results provide evidence for the neuroprotective action of DU-14 against neurotoxic Abeta, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Abeta-induced impairments in spatial memory and synaptic plasticity.	Dehydroepiandrosterone Sulfate	141-146	amyloid beta precursor protein	Rattus norvegicus	90-95
27033324-3	2016	More than 100 compounds of different molecular structures were screened for inhibition of the SOAT-mediated transport of dehydroepiandrosterone sulfate in stably transfected SOAT-HEK293 cells.	Dehydroepiandrosterone Sulfate	121-151	solute carrier family 10 member 6	Homo sapiens	174-178
26910580-2	2016	The aim of this study is to compare serum total and free prolactin and dehydroepiandrosterone sulfate (DHEAS) levels between patients with pemphigus and healthy controls and to determine the correlation of these hormones with disease severity.	Dehydroepiandrosterone Sulfate	71-101	sulfotransferase family 2A member 1	Homo sapiens	103-108
27003302-1	2016	CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA.	Dehydroepiandrosterone Sulfate	116-129	steroid sulfatase	Homo sapiens	9-26
27003302-1	2016	CONTEXT: Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including dehydroepiandrosterone (DHEA) sulfate (DHEAS), the inactive sulfate ester of the adrenal androgen precursor DHEA.	Dehydroepiandrosterone Sulfate	116-129	sulfotransferase family 2A member 1	Homo sapiens	131-136
26668348-4	2016	The expression of SLCO2B1 was examined in prostatectomy samples, and the impact of SLCO2B1 expression level on DHEAS (dehydroepiandrosterone sulfate) uptake was evaluated in cell lines.	Dehydroepiandrosterone Sulfate	118-148	solute carrier organic anion transporter family member 2B1	Homo sapiens	83-90
26792191-4	2016	However, the Sig-1R agonists, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), reduced the activation of apoptotic pathways significantly.	Dehydroepiandrosterone Sulfate	64-76	sigma non-opioid intracellular receptor 1	Mus musculus	13-19
26792191-4	2016	However, the Sig-1R agonists, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS), reduced the activation of apoptotic pathways significantly.	Dehydroepiandrosterone Sulfate	78-83	sigma non-opioid intracellular receptor 1	Mus musculus	13-19
26940356-3	2016	The c-ACC produced not only abundant dehydroepiandrosterone-sulfate but also a large amount of testosterone via the Delta5 pathway with Delta5-androstenediol rather than Delta4-androstenedione as the primary intermediate metabolite.	Dehydroepiandrosterone Sulfate	37-67	chloride channel accessory 1	Homo sapiens	4-9
26976654-10	2016	These findings suggest that the effect of DHEA on insulin action in the liver is self-mediated by DHEA or DHEA sulfate (DHEA-S) in the presence of IRS1, IRS2, or both.	Dehydroepiandrosterone Sulfate	106-118	insulin receptor substrate 1	Mus musculus	147-151
26976654-10	2016	These findings suggest that the effect of DHEA on insulin action in the liver is self-mediated by DHEA or DHEA sulfate (DHEA-S) in the presence of IRS1, IRS2, or both.	Dehydroepiandrosterone Sulfate	106-118	insulin receptor substrate 2	Mus musculus	153-157
27112552-4	2016	Dehydroepiandrosterone sulfate (DHEAS) is exclusively produced by adrenals and, therefore, reflects adrenal androgen production in the zona reticularis.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
27045715-0	2016	Correction: Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnalpha11-Coupled Receptor in Sertoli Cells.	Dehydroepiandrosterone Sulfate	12-42	claudin 3	Homo sapiens	98-114
26926599-4	2016	METHODS: Multivariable regression models were implemented to assess cross-sectional and longitudinal associations of TT, free testosterone (fT), ASD, SHBG and dehydroepiandrosterone-sulphate (DHEAS) with measures of subclinical CVD including intima media thickness (IMT), carotid plaques, left ventricular mass (LVM), fractional shortening (FS), relative wall thickness (RWT), and left ventricular geometry.	Dehydroepiandrosterone Sulfate	159-190	sulfotransferase family 2A member 1	Homo sapiens	192-197
26938869-0	2016	Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnalpha11-Coupled Receptor in Sertoli Cells.	Dehydroepiandrosterone Sulfate	0-30	claudin 3	Homo sapiens	86-102
26938869-1	2016	Dehydroepiandrosterone sulfate (DHEAS) is a circulating sulfated steroid considered to be a pro-androgen in mammalian physiology.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
26760244-1	2016	Sulfotransferase 2A1 (SULT2A1) is a major catalyst of the sulfation of dehydroepiandrosterone (DHEA) to dehydroepiandrosterone sulfate (DHEA-S) in human liver cytosol.	Dehydroepiandrosterone Sulfate	104-134	sulfotransferase family 2A member 1	Homo sapiens	0-20
26760244-1	2016	Sulfotransferase 2A1 (SULT2A1) is a major catalyst of the sulfation of dehydroepiandrosterone (DHEA) to dehydroepiandrosterone sulfate (DHEA-S) in human liver cytosol.	Dehydroepiandrosterone Sulfate	104-134	sulfotransferase family 2A member 1	Homo sapiens	22-29
26510996-9	2016	The Slc10a6 substrate dehydroepiandrosterone sulfate (DHEAS) enhanced LPS induction of CCL5 mRNA, a pro-inflammatory chemokine, by 50% in RAW264.7 cells.	Dehydroepiandrosterone Sulfate	22-52	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	Mus musculus	4-11
26510996-9	2016	The Slc10a6 substrate dehydroepiandrosterone sulfate (DHEAS) enhanced LPS induction of CCL5 mRNA, a pro-inflammatory chemokine, by 50% in RAW264.7 cells.	Dehydroepiandrosterone Sulfate	22-52	chemokine (C-C motif) ligand 5	Mus musculus	87-91
26510996-9	2016	The Slc10a6 substrate dehydroepiandrosterone sulfate (DHEAS) enhanced LPS induction of CCL5 mRNA, a pro-inflammatory chemokine, by 50% in RAW264.7 cells.	Dehydroepiandrosterone Sulfate	54-59	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	Mus musculus	4-11
26510996-9	2016	The Slc10a6 substrate dehydroepiandrosterone sulfate (DHEAS) enhanced LPS induction of CCL5 mRNA, a pro-inflammatory chemokine, by 50% in RAW264.7 cells.	Dehydroepiandrosterone Sulfate	54-59	chemokine (C-C motif) ligand 5	Mus musculus	87-91
26510996-11	2016	CONCLUSION: Dramatic upregulation of Slc10a6 mRNA by LPS combined with enhanced LPS stimulation of CCL5 expression by the Slc10a6 substrate DHEAS in macrophages suggests that Slc10a6 function contributes to the hepatic inflammatory response.	Dehydroepiandrosterone Sulfate	140-145	chemokine (C-C motif) ligand 5	Mus musculus	99-103
26510996-11	2016	CONCLUSION: Dramatic upregulation of Slc10a6 mRNA by LPS combined with enhanced LPS stimulation of CCL5 expression by the Slc10a6 substrate DHEAS in macrophages suggests that Slc10a6 function contributes to the hepatic inflammatory response.	Dehydroepiandrosterone Sulfate	140-145	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	Mus musculus	122-129
26510996-11	2016	CONCLUSION: Dramatic upregulation of Slc10a6 mRNA by LPS combined with enhanced LPS stimulation of CCL5 expression by the Slc10a6 substrate DHEAS in macrophages suggests that Slc10a6 function contributes to the hepatic inflammatory response.	Dehydroepiandrosterone Sulfate	140-145	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	Mus musculus	122-129
26923336-1	2016	OBJECTIVE: A large body of clinical data suggests the importance of endogenous sex hormones in the pathogenesis of diabetes, but very little is known about the possible relationship between dehydroepiandrosterone sulfate (DHEAS) and diabetes, particularly in the elderly.	Dehydroepiandrosterone Sulfate	190-220	sulfotransferase family 2A member 1	Homo sapiens	222-227
26772981-6	2016	Plasma dehydroepiandrosterone sulfate (DHEA-S) was elevated.	Dehydroepiandrosterone Sulfate	7-37	sulfotransferase family 2A member 1	Homo sapiens	39-45
27100685-3	2016	The aim of this study was to evaluate dehydroepiandrosterone sulfate (DHEA-S) and progesterone plasma levels in drug-free patients with major psychoses and their relation with the diagnosis and history of psychotic symptoms.	Dehydroepiandrosterone Sulfate	38-68	sulfotransferase family 2A member 1	Homo sapiens	70-76
26924986-4	2016	Sulfatase and sulfotransferases have pivotal roles in these processes, where sulfatase hydrolyzes estrone sulfate to estrone, and dehydroepiandrosterone sulfate to dehydroepiandrosterone, and sulfotransferases catalyze the reverse reactions.	Dehydroepiandrosterone Sulfate	130-160	arylsulfatase family member H	Homo sapiens	0-9
27533747-4	2016	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are neurosteroids that modulate inhibitory GABA receptors and excitatory NMDA receptors, producing complex neuronal effects.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
26666359-0	2016	Estrone sulfate and dehydroepiandrosterone sulfate: Transactivation of the estrogen and androgen receptor.	Dehydroepiandrosterone Sulfate	20-50	androgen receptor	Homo sapiens	88-105
26666359-1	2016	Dehydroepiandrosterone sulfate (DHEAS) and estrone sulfate (E1S) are two of the most abundant steroids in the human circulation.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
25828095-2	2015	The adrenal androgens dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) are thought to be beneficial to immune function and disease resistance, but physiologically interact with testosterone and cortisol.	Dehydroepiandrosterone Sulfate	56-86	sulfotransferase family 2A member 1	Homo sapiens	88-94
26811582-3	2015	For evaluation of the androgen excess, testosterone and dehydroepiandrosterone sulfate (DHEA-S) are the first laboratory tests to be measured.	Dehydroepiandrosterone Sulfate	56-86	sulfotransferase family 2A member 1	Homo sapiens	88-94
25988799-3	2015	Bidirectional sequencing of the coding regions and intron/exon boundaries of FOXL2 and BMP15 genes and hormonal assays for the measurement of follicle-stimulating hormone, luteinizing hormone, estradiol, testosterone, Delta4-androstenedione, and dehydroepiandrosterone sulfate were employed.	Dehydroepiandrosterone Sulfate	246-276	bone morphogenetic protein 15	Homo sapiens	87-92
25692973-0	2015	The association between serum dehydroepiandrosterone Sulphate (DHEA-S) level and bone mineral density in Korean men.	Dehydroepiandrosterone Sulfate	30-61	sulfotransferase family 2A member 1	Homo sapiens	63-69
25820021-3	2015	Uptake of olmesartan by human placental BM vesicles was potently inhibited by dehydroepiandrosterone sulfate (DHEAS), estrone 3-sulfate, and bromosulfophthalein, which are all typical substrates of organic anion transporter (OAT) 4 localized at the BM of syncytiotrophoblasts, and was increased in the absence of chloride.	Dehydroepiandrosterone Sulfate	78-108	sulfotransferase family 2A member 1	Homo sapiens	110-115
26036454-1	2015	BACKGROUND: Major depressive disorder (MDD) has been associated with low dehydroepiandrosterone-sulphate (DHEAS), - particularly relative to high cortisol - although conflicting findings exist.	Dehydroepiandrosterone Sulfate	73-104	sulfotransferase family 2A member 1	Homo sapiens	106-111
25706901-1	2015	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) are the most abundant circulating adrenal steroid hormones.	Dehydroepiandrosterone Sulfate	34-65	sulfotransferase family 2A member 1	Homo sapiens	67-72
25537161-2	2015	OBJECTIVE: Dehydroepiandrosterone sulfate (DHEAS) appears to have a protective effect against depression, but contrasting findings are available.	Dehydroepiandrosterone Sulfate	11-41	sulfotransferase family 2A member 1	Homo sapiens	43-48
26356576-3	2015	This study investigated the putative role of steroid hormones such as oestradiol, testosterone, and dehydroepiandrosterone sulphate (DHEAS) as underlying factors influencing cerebral perfusion.	Dehydroepiandrosterone Sulfate	100-131	sulfotransferase family 2A member 1	Homo sapiens	133-138
26248856-2	2015	When plasma ACTH values are inconclusive, a differential diagnosis of CS can be made based upon measurement of the serum dehydroepiandrosterone sulfate (DHEA-S) level and results of the high-dose dexamethasone suppression test (HDST).	Dehydroepiandrosterone Sulfate	121-151	sulfotransferase family 2A member 1	Homo sapiens	153-159
25725785-1	2015	The gamma-aminobutyric acid type A receptor (GABAAR) is negatively modulated by two structurally similar neurosteroids, pregnenolone sulfate (PS) and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	150-180	sulfotransferase family 2A member 1	Homo sapiens	182-187
26071787-1	2015	OBJECTIVE: Dehydroepiandrosterone sulphate (DHEA-s) is an anabolic protective hormone.	Dehydroepiandrosterone Sulfate	11-42	sulfotransferase family 2A member 1	Homo sapiens	44-50
25919187-5	2015	Uptake of [(3)H]16alpha-OH DHEAS by BM vesicles was significantly inhibited by OAT4 substrates such as dehydroepiandrosterone sulfate, estrone-3-sulfate, and bromosulfophthalein but not by cyclosporin A, tetraethylammonium, p-aminohippuric acid, or cimetidine.	Dehydroepiandrosterone Sulfate	103-133	solute carrier family 22 member 11	Homo sapiens	79-83
25868050-4	2015	Treatment of H295R cells with BMP4 caused phosphorylation of the mothers against decapentaplegic and a profound decrease in synthesis of the C19 steroids dehydroepiandrosterone (DHEA), DHEA sulfate, and androstenedione.	Dehydroepiandrosterone Sulfate	185-197	bone morphogenetic protein 4	Homo sapiens	30-34
26122298-0	2015	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) and emotional processing - A behavioral and electrophysiological approach.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
26122298-1	2015	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) may have mood enhancement effects: higher DHEAS concentrations and DHEA/cortisol ratio have been related to lower depression scores and controlled trials of DHEA administration have reported significant antidepressant effects.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
26122298-1	2015	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) may have mood enhancement effects: higher DHEAS concentrations and DHEA/cortisol ratio have been related to lower depression scores and controlled trials of DHEA administration have reported significant antidepressant effects.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	115-120
25381943-1	2015	AIM: In this study, parameters of metabolic syndrome and dehydroepiandrosterone sulfate (DHEAS) levels in obese children and adolescents were evaluated and the associations between these factors were analyzed.	Dehydroepiandrosterone Sulfate	57-87	sulfotransferase family 2A member 1	Homo sapiens	89-94
26181260-2	2015	Dehydroepiandrosterone sulfate (DHEAS) is a precursor of testosterone and a substrate for SLCO2B1, an organic anionic transporter.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
26181260-2	2015	Dehydroepiandrosterone sulfate (DHEAS) is a precursor of testosterone and a substrate for SLCO2B1, an organic anionic transporter.	Dehydroepiandrosterone Sulfate	0-30	solute carrier organic anion transporter family member 2B1	Homo sapiens	90-97
26079405-8	2015	Mean DHEAS concentrations (+-standard deviation) in the FH subjects and female siblings were normally distributed within the reference interval, whereas male siblings had a higher mean DHEAS concentration than their FH brothers (12.9 [+- 4.9] vs. 8.4 [+- 3.0] mumol/L, respectively, p &lt; 0.0001).	Dehydroepiandrosterone Sulfate	5-10	low density lipoprotein receptor	Homo sapiens	56-58
25514466-0	2015	The DHEA-sulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer.	Dehydroepiandrosterone Sulfate	4-16	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	33-40
25514466-0	2015	The DHEA-sulfate depot following P450c17 inhibition supports the case for AKR1C3 inhibition in high risk localized and advanced castration resistant prostate cancer.	Dehydroepiandrosterone Sulfate	4-16	aldo-keto reductase family 1 member C3	Homo sapiens	74-80
25488489-0	2015	Age-related serum dehydroepiandrosterone sulphate (DHEAS) levels per se should not be considered a reliable surrogate parameter for clinical presentation of adrenarche.	Dehydroepiandrosterone Sulfate	18-49	sulfotransferase family 2A member 1	Homo sapiens	51-56
25502945-2	2015	In particular, lower dehydroepiandrosterone sulfate (DHEAS) levels were consistently found in a subset of premenopausal RA females.	Dehydroepiandrosterone Sulfate	21-51	sulfotransferase family 2A member 1	Homo sapiens	53-58
28962410-9	2015	Dehydroepiandosterone sulfate (DHEAS) is a reported endogenous ligand of PPARA so its competitive role was also studied.	Dehydroepiandrosterone Sulfate	31-36	peroxisome proliferator activated receptor alpha	Homo sapiens	73-78
25555552-2	2015	We analyzed hormone levels of dehydroepiandrosterone sulfate (DHEAS) and insulin-like growth factor-I (IGF-I), which are hypothesized to be two pathways linking early growth with adult diseases (such as type 2 diabetes and cardiovascular disease) via their effects on enhanced insulin resistance.	Dehydroepiandrosterone Sulfate	30-60	sulfotransferase family 2A member 1	Homo sapiens	62-67
26311455-8	2015	Levels of adiponectin were positively correlated with SHBG (r = 0.536, P &lt; 0.05) and negatively with FAI (r = -0.363, P &lt; 0.05) in menopausal transition, while in late postmenopausal group, negatively correlated with level of DHEA-S (r = -0.450, P &lt; 0.05).	Dehydroepiandrosterone Sulfate	232-238	adiponectin, C1Q and collagen domain containing	Homo sapiens	10-21
25594860-2	2015	Impaired DHEA sulfation is thought to increase the conversion of DHEA toward active androgens, a proposition supported by the previous report of a girl with inactivating PAPSS2 mutations who presented with low serum DHEA sulfate and androgen excess, clinically manifesting with premature pubarche and early-onset polycystic ovary syndrome.	Dehydroepiandrosterone Sulfate	216-228	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	170-176
25989893-3	2015	In this study, we investigate the possible use of dehydroepiandrosterone sulfate (DHEAS), an endogenous OATP substrate, in predicting OATP-mediated DDI in cynomolgus monkeys as a first step toward in human assessment.	Dehydroepiandrosterone Sulfate	50-80	sulfotransferase family 2A member 1	Homo sapiens	82-87
25747464-3	2015	Higher endogenous levels of the excitatory neurosteroid dehydroepiandrosterone sulfate (DHEAS) were reported to correlate with successful abstinence from cocaine use in addicts, but a clinical trial showed that supplementation with a high dose of DHEA increased cocaine usage instead.	Dehydroepiandrosterone Sulfate	56-86	sulfotransferase family 2A member 1	Homo sapiens	88-93
25594860-3	2015	PATIENTS AND METHODS: We investigated a family harboring two novel PAPSS2 mutations, including two compound heterozygous brothers presenting with disproportionate short stature, low serum DHEA sulfate, but normal serum androgens.	Dehydroepiandrosterone Sulfate	188-200	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	67-73
25786523-7	2015	Regarding other enzymes associated with hepatic fatty acid oxidation, the expression levels of sirtuin 1, sirtuin 6, and carnitine palmitoyltransferase 1 were also upregulated most markedly by treatment with DHEAS alone.	Dehydroepiandrosterone Sulfate	208-213	sirtuin 1	Rattus norvegicus	95-104
25786523-7	2015	Regarding other enzymes associated with hepatic fatty acid oxidation, the expression levels of sirtuin 1, sirtuin 6, and carnitine palmitoyltransferase 1 were also upregulated most markedly by treatment with DHEAS alone.	Dehydroepiandrosterone Sulfate	208-213	sirtuin 6	Rattus norvegicus	106-115
25256364-1	2015	AIM: To assess the role of first trimester maternal testosterone and dehydroepiandrosterone sulfate (DHEA-S) levels in prediction of development of gestational diabetes mellitus (GDM).	Dehydroepiandrosterone Sulfate	69-99	sulfotransferase family 2A member 1	Homo sapiens	101-107
25595042-2	2015	In the present study, a validated LC-MS/MS method is described for the simultaneous quantification of dehydroepiandrosterone sulfate (DHEA-S), estrone sulfate (E1-S), androsterone sulfate (ADT-S), pregnenolone sulfate (Preg-S) and allopregnanolone sulfate (Allopreg-S).	Dehydroepiandrosterone Sulfate	102-132	sulfotransferase family 2A member 1	Homo sapiens	134-140
25738591-1	2015	OBJECTIVE: The aim of our study was to determine whether serum dehydroepiandrosterone sulphate (DHEAS) concentration and the models incorporating it could help clinicians to predict IVF outcomes in women with normal ovarian reserve undergoing their first long protocol.	Dehydroepiandrosterone Sulfate	63-94	sulfotransferase family 2A member 1	Homo sapiens	96-101
25146553-1	2015	The diagnostic accuracy of dehydroepiandrosterone sulfate (DHEAS) to predict subclinical Cushing"s syndrome (sCS) has been a matter of debate.	Dehydroepiandrosterone Sulfate	27-57	sulfotransferase family 2A member 1	Homo sapiens	59-64
25514100-2	2015	OBJECTIVE: This study aimed to assess dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) levels in relation to body mass index (BMI) in PCOS.	Dehydroepiandrosterone Sulfate	72-102	sulfotransferase family 2A member 1	Homo sapiens	104-109
23571826-1	2015	OBJECTIVE: The objective of this article is to measure serum dehydroepiandrosterone sulfate (DHEA-S) concentration in both genders with primary aldosteronism (PA).	Dehydroepiandrosterone Sulfate	61-91	sulfotransferase family 2A member 1	Homo sapiens	93-99
24593938-10	2014	Moreover, serum AMH correlated positively with luteinizing hormone, total testosterone, and dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	92-122	anti-Mullerian hormone	Homo sapiens	16-19
25643392-1	2015	Recent evidence suggests that increased dehydroepiandrosterone sulfate (DHEAS), in combination with decreased cortisol levels have been correlated with enhanced performance outcomes in stressful military environments.	Dehydroepiandrosterone Sulfate	40-70	sulfotransferase family 2A member 1	Homo sapiens	72-77
25482393-2	2015	This study investigated whether the levels of total testosterone, free testosterone, and dehydroepiandrosterone sulfate (DHEA-S) in serum were associated with personality traits related to novelty seeking (NS) and its subscales in healthy Japanese male subjects (n=178).	Dehydroepiandrosterone Sulfate	89-119	sulfotransferase family 2A member 1	Homo sapiens	121-127
24704255-1	2015	The dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) concentrations during acute and chronic exercise (training) have been investigated only fairly recently.	Dehydroepiandrosterone Sulfate	38-68	sulfotransferase family 2A member 1	Homo sapiens	70-76
24704256-1	2015	Although very little is known about the importance of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) in human physiology and pathophysiology, emerging observations imply pivotal roles of DHEA/-S. One such observation is the association between serum DHEA/-S levels and mortality risk.	Dehydroepiandrosterone Sulfate	88-100	sulfotransferase family 2A member 1	Homo sapiens	102-108
25020276-8	2014	Metastin levels correlated significantly positively with luteinizing hormone (LH), total testosterone (T), dehydroepiandrosteronesulphate (DHEA-SO4) levels, modified Ferriman-Gallwey (mFG) scores and free androgen index (FAI); however, correlated negatively with sex hormone binding globulin (SHBG) levels (p&lt;0.05).	Dehydroepiandrosterone Sulfate	107-137	KiSS-1 metastasis suppressor	Homo sapiens	0-8
24903198-13	2014	In the patient population prolactin levels were inversely associated with age, smoking status, waist circumference, total cholesterol, triglyceride and low-density lipoprotein (LDL) and positively associated with high-density lipoprotein, estradiol, total testosterone, dehydroepiandrosterone sulfate, 17-hydroxyprogesterone and cortisol levels.	Dehydroepiandrosterone Sulfate	270-300	prolactin	Homo sapiens	26-35
24845419-2	2014	We examined the effect of physiologically relevant nanomolar concentrations of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S) on miR-21 expression in HepG2 human hepatoma cells.	Dehydroepiandrosterone Sulfate	113-125	microRNA 21	Homo sapiens	138-144
25543039-2	2014	Prolactin (PRL) and DHEA-S (dehydroepiandrosterone sulfate) are stress-associated hormones in chronic urticaria.	Dehydroepiandrosterone Sulfate	28-58	sulfotransferase family 2A member 1	Homo sapiens	20-26
24887210-1	2014	Recent reports demonstrate neurotrophic properties of dehydroepiandrosterone sulfate (DHEAS) in men at rest, as well as profound neurotrophic responses to stress in both men and women.	Dehydroepiandrosterone Sulfate	54-84	sulfotransferase family 2A member 1	Homo sapiens	86-91
25105970-1	2014	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS) have been reported to have memory enhancement effects in humans.	Dehydroepiandrosterone Sulfate	34-65	sulfotransferase family 2A member 1	Homo sapiens	67-72
24612674-1	2014	The association between serum dehydroepiandrosterone sulfate (DHEAS) and cognition was assessed in 218 healthy, midlife, post-menopausal women, aged 55-65 years.	Dehydroepiandrosterone Sulfate	30-60	sulfotransferase family 2A member 1	Homo sapiens	62-67
25905237-0	2000	Adrenal Androgens and Aging Dehydroepiandrosterone (DHEA) and its active metabolite DHEA sulfate (DHEAS), are steroid hormones synthesized and excreted primarily by the zona reticularis of the adrenal cortex in response to adrenocorticotropic hormone (ACTH).	Dehydroepiandrosterone Sulfate	84-96	sulfotransferase family 2A member 1	Homo sapiens	98-103
25905237-0	2000	Adrenal Androgens and Aging Dehydroepiandrosterone (DHEA) and its active metabolite DHEA sulfate (DHEAS), are steroid hormones synthesized and excreted primarily by the zona reticularis of the adrenal cortex in response to adrenocorticotropic hormone (ACTH).	Dehydroepiandrosterone Sulfate	84-96	proopiomelanocortin	Homo sapiens	223-250
24948873-2	2014	The uptake and intratumoral (intracrine) conversion of circulating adrenal androgens such as dehydroepiandrosterone sulfate (DHEA-S) to steroids capable of activating the wild type AR is a recognized driver of castration resistant prostate cancer (CRPC).	Dehydroepiandrosterone Sulfate	125-131	androgen receptor	Homo sapiens	181-183
24754504-3	2014	Serum dehydroepiandrosterone sulfate (DHEAS) levels were lower in most reports of premenopausal-onset RA patients not treated with glucocorticoids and in the baseline levels in one cohort study of pre-RA females compared with CN subjects.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-43
24948873-2	2014	The uptake and intratumoral (intracrine) conversion of circulating adrenal androgens such as dehydroepiandrosterone sulfate (DHEA-S) to steroids capable of activating the wild type AR is a recognized driver of castration resistant prostate cancer (CRPC).	Dehydroepiandrosterone Sulfate	93-123	androgen receptor	Homo sapiens	181-183
24586990-0	2014	Dehydroepiandrosterone sulfate (DHEAS) stimulates the first step in the biosynthesis of steroid hormones.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
23728318-2	2014	This study aims to investigate the impact of dehydroepiandrosterone sulfate (DHEAS) on the clearance of chronic HBV infection.	Dehydroepiandrosterone Sulfate	45-75	sulfotransferase family 2A member 1	Homo sapiens	77-82
23152363-1	2014	BACKGROUND: High plasma dehydroepiandrosterone sulfate (DHEAS) levels have been associated with a reduced risk of cardiovascular disease and atherosclerosis.	Dehydroepiandrosterone Sulfate	24-54	sulfotransferase family 2A member 1	Homo sapiens	56-61
24911578-1	2014	OBJECTIVE: We attempted to investigate whether dehydroepiandrosterone sulfate (DHEA-S) levels are associated with remission of major depressive disorder by assessing scores on the 17-Item Structured Interview Guide for the Hamilton Depression before and after antidepressant treatment.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-85
24586990-1	2014	Dehydroepiandrosterone sulfate (DHEAS) is the most abundant circulating steroid in human, with the highest concentrations between age 20 and 30, but displaying a significant decrease with age.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
23647522-1	2014	We evaluated dehydroepiandrosterone sulfate (DHEAS) levels in premature ovarian failure (POF) patients with and without Hashimoto"s thyroiditis, and the impact of DHEA supplementation on thyroid autoantibodies.	Dehydroepiandrosterone Sulfate	13-43	sulfotransferase family 2A member 1	Homo sapiens	45-50
25610293-9	2014	CONCLUSION: Significant inverse correlations between SSEP latencies and dehydroepiandrosterone sulphate (DHEAS) levels were found (R=-0.400 to -0.713).	Dehydroepiandrosterone Sulfate	72-103	sulfotransferase family 2A member 1	Homo sapiens	105-110
24577112-2	2014	We reported previously that prophylactic postnatal ritonavir-PI therapy in HIV-exposed neonates was associated with increases in plasma 17-hydroxyprogesterone (17-OHP) and dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	172-202	sulfotransferase family 2A member 1	Homo sapiens	204-210
24365022-2	2014	This study investigated DHEAS ability to predict live birth before starting the first gonadotrophin-releasing hormone (GnRH) antagonist ovarian stimulation for IVF/intracytoplasmic sperm injection in young women (&lt;=37years) with low serum AMH (&lt;6.5pmol/l).	Dehydroepiandrosterone Sulfate	24-29	gonadotropin releasing hormone 1	Homo sapiens	119-123
24365022-8	2014	In conclusion, the association between baseline DHEAS and probability of live birth after the GnRH antagonist IVF cycle in young women with low AMH was demonstrated.	Dehydroepiandrosterone Sulfate	48-53	gonadotropin releasing hormone 1	Homo sapiens	94-98
24365022-8	2014	In conclusion, the association between baseline DHEAS and probability of live birth after the GnRH antagonist IVF cycle in young women with low AMH was demonstrated.	Dehydroepiandrosterone Sulfate	48-53	anti-Mullerian hormone	Homo sapiens	144-147
24365022-10	2014	This study demonstrates an association of baseline dehydroepinadrostendione sulphate (DHEAS) concentration with implantation rate and live birth rate after the first gonadotrophin-releasing hormone antagonist IVF cycle in young women who are expected to respond poorly to ovarian stimulation.	Dehydroepiandrosterone Sulfate	86-91	gonadotropin releasing hormone 1	Homo sapiens	166-197
24899908-1	2014	Cytochrome P450 2C9 (CYP2C9) metabolizes dehydroepiandrosterone-sulfate (DHEA-S), but in elderly people the amount of DHEA-S remaining after CYP2C9 metabolization may be insufficient for optimal health.	Dehydroepiandrosterone Sulfate	41-71	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	0-19
24899908-1	2014	Cytochrome P450 2C9 (CYP2C9) metabolizes dehydroepiandrosterone-sulfate (DHEA-S), but in elderly people the amount of DHEA-S remaining after CYP2C9 metabolization may be insufficient for optimal health.	Dehydroepiandrosterone Sulfate	41-71	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	21-27
24899908-1	2014	Cytochrome P450 2C9 (CYP2C9) metabolizes dehydroepiandrosterone-sulfate (DHEA-S), but in elderly people the amount of DHEA-S remaining after CYP2C9 metabolization may be insufficient for optimal health.	Dehydroepiandrosterone Sulfate	41-71	sulfotransferase family 2A member 1	Homo sapiens	73-79
25359306-2	2014	ACTH-dependent dehydroepiandrosterone sulphate (DHEAS) has been postulated as a possible marker of adrenal function in adult patients.	Dehydroepiandrosterone Sulfate	15-46	proopiomelanocortin	Homo sapiens	0-4
25359306-2	2014	ACTH-dependent dehydroepiandrosterone sulphate (DHEAS) has been postulated as a possible marker of adrenal function in adult patients.	Dehydroepiandrosterone Sulfate	15-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
25505909-8	2014	Free testosterone (T) and dehydroepiandrosterone sulfate (DHEA-S) were found to be higher in the cases (2.78 +- 1.24 pg/mL and 231.50 +- 127.20 mu/dL) when compared to the control group (1.50 +- 0.75 pg/mL and 133.59 +- 60.69 mu/dL) (P = 0.0001 and 0.001), respectively.	Dehydroepiandrosterone Sulfate	26-56	sulfotransferase family 2A member 1	Homo sapiens	58-64
24401326-3	2014	METHODS: The aim of this work consisted in assessing, by ELISA, fasting plasma levels of DBI and dehydroepiandrosterone sulphate (DHEA-S), including cortisol and the cortisol-to-DHEA-S molar ratio (CDR), in 17 BPD adolescents versus 13 healthy controls, testing the possibility that clinical scales related to depressive or anxious traits (CDI, STAI-Y) or to disease severity (BPDCL) might be associated with a selective dysregulation of these parameters.	Dehydroepiandrosterone Sulfate	97-128	sulfotransferase family 2A member 1	Homo sapiens	130-136
23562556-6	2013	Stably transfected mSoat-HEK293 cells revealed sodium-dependent transport for dehydroepiandrosterone sulfate (DHEAS), estrone-3-sulfate, and pregnenolone sulfate (PREGS) with apparent Km values of 60.3muM, 2.1muM, and 2.5muM, respectively.	Dehydroepiandrosterone Sulfate	78-108	sulfotransferase family 2A member 1	Homo sapiens	110-115
23478936-9	2013	A decrease of dehydroepiandrosterone sulfate (DHEA-S) and 5alpha-androstan-3beta ol-17-one sulfate (etiocholanolone-S) was observed with the progression of fibrosis.	Dehydroepiandrosterone Sulfate	14-44	sulfotransferase family 2A member 1	Homo sapiens	46-52
23567366-1	2013	OBJECTIVE: Dehydroepiandrosterone sulfate (DHEAS) appears to have a protective effect against depression, but evidence from prospective cohort studies is sparse.	Dehydroepiandrosterone Sulfate	11-41	sulfotransferase family 2A member 1	Homo sapiens	43-48
24120945-5	2013	DHEAS inhibited the AMPK activation and upregulated the expression of ACC-1.	Dehydroepiandrosterone Sulfate	0-5	acetyl-Coenzyme A carboxylase alpha	Mus musculus	70-75
24120945-6	2013	These findings indicate that DHEAS may exert prominent stimulatory effects on insulin secretion partly via AMPK inhibition and ACC-1 upregulation.	Dehydroepiandrosterone Sulfate	29-34	acetyl-Coenzyme A carboxylase alpha	Mus musculus	127-132
23988737-0	2013	Dehydroepiandrosterone sulfate mediates activation of transcription factors CREB and ATF-1 via a Galpha11-coupled receptor in the spermatogenic cell line GC-2.	Dehydroepiandrosterone Sulfate	0-30	cAMP responsive element binding protein 1	Homo sapiens	76-80
23988737-0	2013	Dehydroepiandrosterone sulfate mediates activation of transcription factors CREB and ATF-1 via a Galpha11-coupled receptor in the spermatogenic cell line GC-2.	Dehydroepiandrosterone Sulfate	0-30	activating transcription factor 1	Homo sapiens	85-90
23988737-1	2013	Dehydroepiandrosterone sulfate (DHEAS) is a circulating steroid produced in the adrenal cortex, brain, and gonads.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
23642338-3	2013	OBJECTIVE: To psychologically assess resilience in a non-clinical community population through questionnaires, and analyse the associations between the psychological parameters and salivary cortisol and dehydroepiandrosterone sulphate (DHEA-S) as putative biomarkers of resilience.	Dehydroepiandrosterone Sulfate	203-234	sulfotransferase family 2A member 1	Homo sapiens	236-242
23861462-0	2013	Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.	Dehydroepiandrosterone Sulfate	31-44	sulfotransferase family 2A member 1	Homo sapiens	12-19
24406129-6	2013	The analyses suggested that in early postmenopausal group, SHBG was correlated negatively with FINS and HOMA-IR (beta = -0.386, P &lt; 0.05;beta = -0.553, P &lt; 0.05) , DHEA-S was correlated positively with FBG (beta = 0.348, P &lt; 0.05) in early postmenopausal group.FAI was correlated positively with FBG in late postmenopausal group (beta = 0.505, P &lt; 0.05) .	Dehydroepiandrosterone Sulfate	170-176	sex hormone binding globulin	Homo sapiens	59-63
23933097-5	2013	These effects of DHEAS were potentiated by intracerebroventricular pretreatment with subeffective dose of CART.	Dehydroepiandrosterone Sulfate	17-22	CART prepropeptide	Rattus norvegicus	106-110
23665079-0	2013	Measurement of dehydroepiandrosterone sulphate (DHEAS): a comparison of Isotope-Dilution Liquid Chromatography Tandem Mass Spectrometry (ID-LC-MS/MS) and seven currently available immunoassays.	Dehydroepiandrosterone Sulfate	15-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
23665079-1	2013	BACKGROUND: Dehydroepiandrosterone sulphate (DHEAS) is an important marker of the adrenal gland.	Dehydroepiandrosterone Sulfate	12-43	sulfotransferase family 2A member 1	Homo sapiens	45-50
23751811-0	2013	The influence of age and season on fecal dehydroepiandrosterone-sulfate (DHEAS) concentrations in Japanese macaques (Macaca fuscata).	Dehydroepiandrosterone Sulfate	41-71	sulfotransferase family 2A member 1	Homo sapiens	73-78
23861462-9	2013	SNP rs2910397 in SULT2A1 decreased the DHEAS to DHEA ratio in PCOS by 5% in the discovery sample.	Dehydroepiandrosterone Sulfate	39-44	sulfotransferase family 2A member 1	Homo sapiens	17-24
23861462-13	2013	Although a variant in SULT2A1 decreased the DHEAS to DHEA ratio, no changes in other androgenic hormone levels were observed.	Dehydroepiandrosterone Sulfate	44-49	sulfotransferase family 2A member 1	Homo sapiens	22-29
23428256-1	2013	BACKGROUND: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to play a protective role during acute psychosocial stress, because they act as antagonists to the effects of the stress hormone cortisol.	Dehydroepiandrosterone Sulfate	46-76	sulfotransferase family 2A member 1	Homo sapiens	78-84
24015247-2	2013	One of the consequences of prolonged psychosocial stress may be a negative effect on the levels of dehydroepiandrosterone (DHEA) and its sulphated metabolite dehydroepiandrosterone sulphate (DHEA-S).	Dehydroepiandrosterone Sulfate	158-189	sulfotransferase family 2A member 1	Homo sapiens	191-197
23906954-8	2013	Only DHEAS and UFC (nmol/m(2)) were statistically significant-DHEAS for PMTP ACTH and 11DOC (r=0.20, p=0.025 and r=0.21, p=0.017); UFC (nmol/m(2)) for PMTP 11DOC and 11DOC+C (r=0.19, p=0.033 and r=0.20, p=0.022).	Dehydroepiandrosterone Sulfate	5-10	proopiomelanocortin	Homo sapiens	77-81
23906954-8	2013	Only DHEAS and UFC (nmol/m(2)) were statistically significant-DHEAS for PMTP ACTH and 11DOC (r=0.20, p=0.025 and r=0.21, p=0.017); UFC (nmol/m(2)) for PMTP 11DOC and 11DOC+C (r=0.19, p=0.033 and r=0.20, p=0.022).	Dehydroepiandrosterone Sulfate	62-67	proopiomelanocortin	Homo sapiens	77-81
23508718-0	2013	Relationship of dehydroepiandrosterone sulfate with overweight and insulin sensitivity in 12-16-year-old Spanish children.	Dehydroepiandrosterone Sulfate	16-46	insulin	Homo sapiens	67-74
23771199-2	2013	Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are neurosteroids that have been associated with mood measures as well as smoking status, and nicotine is associated with increased DHEA and DHEAS levels.	Dehydroepiandrosterone Sulfate	34-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
23771199-2	2013	Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are neurosteroids that have been associated with mood measures as well as smoking status, and nicotine is associated with increased DHEA and DHEAS levels.	Dehydroepiandrosterone Sulfate	34-46	sulfotransferase family 2A member 1	Homo sapiens	196-201
23669015-7	2013	For AMH and DHEAS, an inverse relationship is found, while gonadotrophin concentrations are negligible during gestation.	Dehydroepiandrosterone Sulfate	12-17	anti-Mullerian hormone	Homo sapiens	4-7
23704104-1	2013	BACKGROUND AND PURPOSE: Previous research suggests greater risk of coronary heart disease with lower levels of the adrenal steroid dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	131-161	sulfotransferase family 2A member 1	Homo sapiens	163-168
23278234-9	2013	Free Androgen Index (FAI) levels were higher in patients with PON1-108 TT, whereas Testosterone, FAI and Dehydroepiandrosterone sulphate (DHEAS) levels were higher in patients with PON1-192 RR than patients with the wild or the heterozygous genotype.	Dehydroepiandrosterone Sulfate	138-143	paraoxonase 1	Homo sapiens	181-185
23685429-1	2013	The present study aimed to develop a novel method for simultaneous assay of cortisol, cortisone and dehydroepiandrosterone sulfate (DHEAS) in human hair.	Dehydroepiandrosterone Sulfate	100-130	sulfotransferase family 2A member 1	Homo sapiens	132-137
23554453-0	2013	Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus.	Dehydroepiandrosterone Sulfate	87-117	gonadotropin releasing hormone 1	Homo sapiens	0-30
23554453-1	2013	The sulfated neurosteroids pregnenolone sulfate (Delta(5)PS) and dehydroepiandrosterone sulfate (DHEAS) are known to play a role in the control of reproductive behavior.	Dehydroepiandrosterone Sulfate	65-95	sulfotransferase family 2A member 1	Homo sapiens	97-102
23435031-1	2013	OBJECTIVE: We propose that the adrenal gland of an older higher primate female animal model will respond to human chorionic gonadotropin (hCG) hormone challenge by secreting additional dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	185-215	chorionic gonadotropin subunit beta 5	Homo sapiens	138-141
23524530-7	2013	The higher conversion of DHEAS to testosterone in subjects with EE indicates increased 17beta-HSD activity via the Delta5-pathway.	Dehydroepiandrosterone Sulfate	25-30	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	87-97
23466819-1	2013	Steroid sulfatase (STS) is an enzyme that hydrolyzes steroid sulfates such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate.	Dehydroepiandrosterone Sulfate	78-108	steroid sulfatase	Homo sapiens	0-17
23466819-1	2013	Steroid sulfatase (STS) is an enzyme that hydrolyzes steroid sulfates such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate.	Dehydroepiandrosterone Sulfate	78-108	sulfotransferase family 2A member 1	Homo sapiens	110-116
23667501-9	2013	With this technique, the cellular inward-directed SOAT transport was verified for the established substrates dehydroepiandrosterone sulfate and estrone-3-sulfate.	Dehydroepiandrosterone Sulfate	109-139	solute carrier family 10 member 6	Homo sapiens	50-54
23688217-1	2013	OBJECTIVE: Dehydroepiandrosterone sulfate (DHEAS) levels and cognitive function decline with age, and a role for DHEAS in supporting cognition has been proposed.	Dehydroepiandrosterone Sulfate	11-41	sulfotransferase family 2A member 1	Homo sapiens	43-48
23858799-8	2013	Markers of insulin resistance such as higher body mass index (BMI) which was statistically significantly related to MA (p= 0.241, p&lt;0.05) and higher dehydroepiandrosterone sulfate (DHEA-S) which was significantly higher in patients with MA (7.82 micromol/L vs. 5.02 micromol/L, p&lt;0.01), were also identified as predictors but did not remain significant by multivariate analysis, possibly because of a small sample of subjects with persistent MA.	Dehydroepiandrosterone Sulfate	152-182	insulin	Homo sapiens	11-18
23858799-8	2013	Markers of insulin resistance such as higher body mass index (BMI) which was statistically significantly related to MA (p= 0.241, p&lt;0.05) and higher dehydroepiandrosterone sulfate (DHEA-S) which was significantly higher in patients with MA (7.82 micromol/L vs. 5.02 micromol/L, p&lt;0.01), were also identified as predictors but did not remain significant by multivariate analysis, possibly because of a small sample of subjects with persistent MA.	Dehydroepiandrosterone Sulfate	184-190	insulin	Homo sapiens	11-18
23858799-9	2013	CONCLUSION: In addition to poor glycemic control and higher night-time systolic blood pressure, markers of insulin resistance (higher insulin dose, higher BMI and higher DHEA-S) contribute to the increased risk of MA.	Dehydroepiandrosterone Sulfate	170-176	insulin	Homo sapiens	107-114
23530294-1	2013	OBJECTIVES: Dehydroepiandrosterone sulfate (DHEAS) declines with age and low endogenous DHEAS concentrations have been associated with obesity.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-49
23314986-1	2013	INTRODUCTION: Dehydroepiandrosterone sulfate (DHEA(S)) is a multi-functional steroid implicated in a broad range of biological effects, including obesity, diabetes, bone metabolism, neuroprotection, and anti-tumorigenesis.	Dehydroepiandrosterone Sulfate	14-44	sulfotransferase family 2A member 1	Homo sapiens	46-53
23386646-8	2013	Dehydroepiandrosterone sulfate (DHEA-S) was quantified by radioimmunoassay.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-38
23435031-1	2013	OBJECTIVE: We propose that the adrenal gland of an older higher primate female animal model will respond to human chorionic gonadotropin (hCG) hormone challenge by secreting additional dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	185-215	sulfotransferase family 2A member 1	Homo sapiens	217-222
23283497-3	2013	OBJECTIVES: The objectives were to assess the associations between obesity indicators and dehydroepiandrosterone sulfate (DHEAS) at 7 y of age and to evaluate the role of hormonal markers on these associations.	Dehydroepiandrosterone Sulfate	90-120	sulfotransferase family 2A member 1	Homo sapiens	122-127
23254310-6	2013	Concomitantly, mitotane             resulted in decreased mRNA levels of two cytochromes P450 (CYP11A1 and CYP17A1),             mRNAs encoding proteins involved in the synthesis of cortisol and DHEAS.	Dehydroepiandrosterone Sulfate	195-200	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	95-102
23254310-6	2013	Concomitantly, mitotane             resulted in decreased mRNA levels of two cytochromes P450 (CYP11A1 and CYP17A1),             mRNAs encoding proteins involved in the synthesis of cortisol and DHEAS.	Dehydroepiandrosterone Sulfate	195-200	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	107-114
22974561-3	2012	CKD patients have several endocrine disorders, including low levels of dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	71-101	sulfotransferase family 2A member 1	Homo sapiens	103-109
23186779-9	2013	Remarkably, the CYP17A1 rs6162 polymorphism was linked to plasma dehydroepiandrosterone-sulfate (DHEA-S) levels (P = 0.03), HSD17B2 rs7201637 with levels of dihydrotestosterone (P = 0.03), and ESR1 rs1062577 with levels of estrone-S and androsterone-glucuronide (P &lt;= 0.05).	Dehydroepiandrosterone Sulfate	65-95	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	16-23
23186779-9	2013	Remarkably, the CYP17A1 rs6162 polymorphism was linked to plasma dehydroepiandrosterone-sulfate (DHEA-S) levels (P = 0.03), HSD17B2 rs7201637 with levels of dihydrotestosterone (P = 0.03), and ESR1 rs1062577 with levels of estrone-S and androsterone-glucuronide (P &lt;= 0.05).	Dehydroepiandrosterone Sulfate	97-103	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	16-23
23436881-0	2013	Relationship between polymorphisms in the sulfotransferase SULT2A1 gene and dehydroepiandrosterone sulfate concentration in children.	Dehydroepiandrosterone Sulfate	76-106	sulfotransferase family 2A member 1	Homo sapiens	59-66
23436881-2	2013	A relationship has been suggested between variations of DHEA-S concentration and polymorphisms in the gene encoding sulfotransferase (SULT2A1), an enzyme that catalyzes the formation of DHEA-S from DHEA.	Dehydroepiandrosterone Sulfate	56-62	sulfotransferase family 2A member 1	Homo sapiens	134-141
23436881-2	2013	A relationship has been suggested between variations of DHEA-S concentration and polymorphisms in the gene encoding sulfotransferase (SULT2A1), an enzyme that catalyzes the formation of DHEA-S from DHEA.	Dehydroepiandrosterone Sulfate	186-192	sulfotransferase family 2A member 1	Homo sapiens	134-141
23436881-3	2013	We have investigated the relationship between the single nucleotide polymorphisms (SNPs) rs2637125 and rs182420 in the SULT2A1 gene and plasma DHEA-S concentration in children at two different ages.	Dehydroepiandrosterone Sulfate	143-149	sulfotransferase family 2A member 1	Homo sapiens	119-126
23436881-8	2013	Our data show an age-related association of polymorphisms in the SULT2A1 gene with lower DHEA-S, suggesting that these polymorphisms may affect DHEA-S concentration in adults.	Dehydroepiandrosterone Sulfate	89-95	sulfotransferase family 2A member 1	Homo sapiens	65-72
23436881-8	2013	Our data show an age-related association of polymorphisms in the SULT2A1 gene with lower DHEA-S, suggesting that these polymorphisms may affect DHEA-S concentration in adults.	Dehydroepiandrosterone Sulfate	144-150	sulfotransferase family 2A member 1	Homo sapiens	65-72
23085263-1	2013	BACKGROUND AND AIMS: Elevated prolactin and reduced dehydroepiandrosterone sulfate (DHEA-S) levels are associated with autoimmune diseases.	Dehydroepiandrosterone Sulfate	52-82	sulfotransferase family 2A member 1	Homo sapiens	84-90
22327820-6	2013	The TF levels directly correlated with percentage of truncal fat and plasma levels of PAI-1, testosterone, androstendione, and dehydroepiandrosterone-sulfate; and inversely correlated with insulin sensitivity index-OGTT(IS(OGTT)).	Dehydroepiandrosterone Sulfate	127-157	coagulation factor III, tissue factor	Homo sapiens	4-6
23356127-6	2013	Standardized beta coefficients revealed that DHEA independently influenced testosterone (beta = 0.40, p &lt; 0.01), whereas DHEAS independently influenced NGF (beta = 0.48, p &lt; 0.01) and sAA (beta = 0.36, p &lt; 0.05).	Dehydroepiandrosterone Sulfate	124-129	nerve growth factor	Homo sapiens	155-158
23388484-8	2012	Osteoprotegerin was negatively correlated with serum dehydroepiandrosterone-sulfate (p=0.008) and with BMD at the lumbar spine (p&lt;0.001) and femoral neck (p=0.003).	Dehydroepiandrosterone Sulfate	53-83	TNF receptor superfamily member 11b	Homo sapiens	0-15
23533429-3	2013	For the evaluation of androgen excess, testosterone and dehydroepiandrosterone sulfate (DHEA-S) are the first laboratory tests to be measured.	Dehydroepiandrosterone Sulfate	56-86	sulfotransferase family 2A member 1	Homo sapiens	88-94
23222704-2	2013	Sarcopenia is a multifactorial process involving the decline of androgens, including dehydroepiandrosterone sulphate (DHEAS) and testosterone.	Dehydroepiandrosterone Sulfate	85-116	sulfotransferase family 2A member 1	Homo sapiens	118-123
23429067-3	2013	Our study aimed to analyze the relationship of adiponectin with dehydroepiandrosterone sulfate, testosterone, estradiol, and sex hormone-binding globulin (SHBG) in adolescents.	Dehydroepiandrosterone Sulfate	64-94	adiponectin, C1Q and collagen domain containing	Homo sapiens	47-58
22982504-1	2012	Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis.	Dehydroepiandrosterone Sulfate	138-169	solute carrier organic anion transporter family member 2B1	Homo sapiens	80-87
22982504-1	2012	Previously, the steroid hormone progesterone has been demonstrated to stimulate OATP2B1-mediated transport of estrone-3-sulphate (E(1)S), dehydroepiandrosterone sulphate (DHEAS) and pregnenolone sulphate (PS), which may influence the uptake of precursor molecules for steroid hormone synthesis.	Dehydroepiandrosterone Sulfate	138-169	sulfotransferase family 2A member 1	Homo sapiens	171-176
22939588-6	2012	Adiponectin levels were negatively correlated with levels of free testosterone, bioavailable testosterone and DHEA-S and were positively correlated with SHBG in postmenopausal women for whom more than 1 year had passed since menopause.	Dehydroepiandrosterone Sulfate	110-116	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
22939588-8	2012	CONCLUSION: Circulating adiponectin level shows a U-curve during the menopausal transition and adiponectin level is associated with levels of free and bioavailable testosterone and DHEA-S in postmenopause.	Dehydroepiandrosterone Sulfate	181-187	adiponectin, C1Q and collagen domain containing	Homo sapiens	95-106
22864060-8	2012	Furthermore, the characteristics of [(3)H]DHEAS uptake by LNCaP cells were consistent with those of OATP-mediated transport.	Dehydroepiandrosterone Sulfate	42-47	solute carrier organic anion transporter family member 1A2	Homo sapiens	100-104
22864060-9	2012	Knockdown of OATP1A2 in LNCaP cells resulted in loss of the DHEAS sensitivity of cell growth.	Dehydroepiandrosterone Sulfate	60-65	solute carrier organic anion transporter family member 1A2	Homo sapiens	13-20
22851486-2	2012	We have recently demonstrated the value of measuring serum dehydroepiandrosterone sulfate (DHEA-S) in establishing the diagnosis of central AI.	Dehydroepiandrosterone Sulfate	59-89	sulfotransferase family 2A member 1	Homo sapiens	91-97
22207707-6	2012	Longitudinal multivariable analyses revealed an  inverse association of baseline TT, free T, and DHEAS concentrations with  change in fibrinogen levels (per SD decrement in TT, 0.25 [95% confidence  interval, 0.04-0.45]; in free T, 0.30 [0.09-0.51]; and in DHEAS,  0.23 [0.11-0.36]).	Dehydroepiandrosterone Sulfate	97-102	fibrinogen beta chain	Homo sapiens	134-144
22764194-2	2012	Serum dehydroepiandrosterone sulfate (DHEA-S), an adrenal androgen with anabolic properties, is known to be lowered in ill patients and predicts poor outcome in the general population and in those with cardiac disease.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-44
22420492-0	2012	Effects of dehydroepiandrosterone sulphate (DHEAS) replacement on insulin action and quality of life in hypopituitary females: a double-blind, placebo-controlled study.	Dehydroepiandrosterone Sulfate	11-42	sulfotransferase family 2A member 1	Homo sapiens	44-49
22420492-0	2012	Effects of dehydroepiandrosterone sulphate (DHEAS) replacement on insulin action and quality of life in hypopituitary females: a double-blind, placebo-controlled study.	Dehydroepiandrosterone Sulfate	11-42	insulin	Homo sapiens	66-73
22420492-1	2012	OBJECTIVE: Addition of dehydroepiandrosterone sulphate (DHEAS) to standard pituitary replacement may improve quality of life and glucose metabolism.	Dehydroepiandrosterone Sulfate	23-54	sulfotransferase family 2A member 1	Homo sapiens	56-61
22207707-6	2012	Longitudinal multivariable analyses revealed an  inverse association of baseline TT, free T, and DHEAS concentrations with  change in fibrinogen levels (per SD decrement in TT, 0.25 [95% confidence  interval, 0.04-0.45]; in free T, 0.30 [0.09-0.51]; and in DHEAS,  0.23 [0.11-0.36]).	Dehydroepiandrosterone Sulfate	257-262	fibrinogen beta chain	Homo sapiens	134-144
21484933-1	2012	The neurosteroid dehydroepiandrosterone-sulfate (DHEAS) is a positive modulator of synaptic transmission in mammalian brains; however, the underlying molecular mechanisms are not fully understood.	Dehydroepiandrosterone Sulfate	17-47	sulfotransferase family 2A member 1	Homo sapiens	49-54
22524205-1	2012	Low serum dehydroepiandrosterone sulfate (DHEAS) is common in older persons with poor health.	Dehydroepiandrosterone Sulfate	10-40	sulfotransferase family 2A member 1	Homo sapiens	42-47
22823430-5	2012	In contrast, in most patients, dehydroepiandrosterone sulfate (DHEAS) levels remained unchanged, although a trend toward increased concentrations was observed in a few cases 3 months after the treatment was finished.	Dehydroepiandrosterone Sulfate	31-61	sulfotransferase family 2A member 1	Homo sapiens	63-68
22644322-2	2012	The aim of this study was to examine the roles of endogenous estradiol (E(2)), sex hormone binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS) in the prediction of incident vertebral and nonvertebral fractures.	Dehydroepiandrosterone Sulfate	120-150	sulfotransferase family 2A member 1	Homo sapiens	152-157
22490610-2	2012	However, it is not known how changes of other GABA(A) receptor modulators such as dehydroepiandrosterone sulfate (DHEAS) contribute to altered GABAergic tone in HE.	Dehydroepiandrosterone Sulfate	82-112	sulfotransferase family 2A member 1	Homo sapiens	114-119
22835450-7	2012	RESULT(S): In multivariate adjusted logistic regression analyses, the odds ratio (OR) for insulin resistance was statistically significantly higher (4.42, range: 2.26-8.67) for women with PCOS who had elevated FT levels compared with the women with normal DHEAS and FT levels (reference group).	Dehydroepiandrosterone Sulfate	256-261	insulin	Homo sapiens	90-97
22835450-10	2012	In multivariate adjusted binary logistic regression analyses, we found a statistically significantly lower risk for insulin resistance in the women with PCOS in the highest DHEAS/FT-ratio quartile compared with women with PCOS in the lowest quartile (OR 0.35, range: 0.14-0.89).	Dehydroepiandrosterone Sulfate	173-178	insulin	Homo sapiens	116-123
21508266-1	2012	The aim of this cross-sectional study was to evaluate serum levels of the hormone, dehydroepiandrosterone sulphate (DHEAS), during the pre-pubertal, pubertal, and adult stages of skeletal maturation based on the methods of Bjork and Grave and Brown of assessing hand-wrist radiographs.	Dehydroepiandrosterone Sulfate	83-114	sulfotransferase family 2A member 1	Homo sapiens	116-121
22693174-2	2012	SUMMARY ANSWERS: The myostatin level was positively correlated to the risk of abdominal obesity, but negatively associated with circulating levels of dehydroepiandrosterone sulfate (DHEAS) and follistatin in women with PCOS.	Dehydroepiandrosterone Sulfate	150-180	myostatin	Homo sapiens	21-30
22693174-2	2012	SUMMARY ANSWERS: The myostatin level was positively correlated to the risk of abdominal obesity, but negatively associated with circulating levels of dehydroepiandrosterone sulfate (DHEAS) and follistatin in women with PCOS.	Dehydroepiandrosterone Sulfate	150-180	sulfotransferase family 2A member 1	Homo sapiens	182-187
22133517-2	2012	In order to investigate this possibility we assessed anxiety and depression with overnight urinary cortisol and plasma dehydroepiandrosterone-sulphate (DHEAS) in 608 factory employees ranging between 21 and 62 years.	Dehydroepiandrosterone Sulfate	119-150	sulfotransferase family 2A member 1	Homo sapiens	152-157
22576257-12	2012	Raised dehydroepiandrosterone sulfate (DHEAS) level was associated with a lower probability of having central obesity (OR 0.293, p=0.001) and overweight (OR 0.47, p=0.023).	Dehydroepiandrosterone Sulfate	7-37	sulfotransferase family 2A member 1	Homo sapiens	39-44
22415563-1	2012	OBJECTIVE: The perimenopausal increase in circulating dehydroepiandrosterone sulfate (DHEAS) levels during the menopausal transition (MT) is accompanied by other adrenal steroids that have the potential to alter estrogen/androgen balance and explain the wide interwoman range of estrogen-related symptoms experienced during the MT.	Dehydroepiandrosterone Sulfate	54-84	sulfotransferase family 2A member 1	Homo sapiens	86-91
22415570-1	2012	OBJECTIVE: It is now recognized that mean circulating dehydroepiandrosterone sulfate (DHEAS) concentrations in most midlife women exhibit a positive inflection starting in early perimenopause, continuing through early postmenopause and returning to early perimenopausal levels by late postmenopause.	Dehydroepiandrosterone Sulfate	54-84	sulfotransferase family 2A member 1	Homo sapiens	86-91
22081112-5	2012	Kakugawa et al., in 2007, found a clear trend toward higher serum level of estrone, estradiol, and dehydroepiandrosterone sulfate in post menopausal women with PR-positive cancer.	Dehydroepiandrosterone Sulfate	99-129	progesterone receptor	Homo sapiens	160-162
22145821-1	2012	Dehydroepiandrosterone sulphate (DHEAS) is synthesised from dehydroepiandrosterone by the enzyme sulphotransferase.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-38
21859802-3	2012	One such enzyme, steroid sulfatase (STS), hydrolyses estrone sulfate, and dehydroepiandrosterone sulfate to estrone and dehydroepiandrosterone respectively.	Dehydroepiandrosterone Sulfate	74-104	steroid sulfatase	Homo sapiens	17-34
22153766-0	2012	Serum levels of dehydroepiandrosterone sulfate (DHEAS) in ocular toxoplasmosis.	Dehydroepiandrosterone Sulfate	16-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
22023042-8	2012	RBP4 showed a positive correlation with serum testosterone (r = 0.62, p &lt; 0.0001), dehydroepiandrosterone sulfate (r = 0.45, p &lt; 0.0001) and the waist circumference (r = 0.37, p &lt; 0.001) of PCOS patients but not with other measured clinical and biochemical variables.	Dehydroepiandrosterone Sulfate	86-116	retinol binding protein 4	Homo sapiens	0-4
22182832-0	2012	Dehydroepiandrosterone-sulfate inhibits thrombin-induced platelet aggregation.	Dehydroepiandrosterone Sulfate	0-30	coagulation factor II, thrombin	Homo sapiens	40-48
23220807-1	2012	OBJECTIVE: This study aims to assess cortisol and dehydroepiandrosterone sulfate (DHEA-S) levels in post-menopausal women with FMS and correlate it with pain threshold and tolerance, depression and quality of life.	Dehydroepiandrosterone Sulfate	50-80	sulfotransferase family 2A member 1	Homo sapiens	82-88
22449989-3	2012	Circulating levels of testosterone and dehydroepiandrosterone sulfate (DHEA-S) gradually decrease with age in postmenopausal women, although transient increases have been observed during the menopausal transition.	Dehydroepiandrosterone Sulfate	39-69	sulfotransferase family 2A member 1	Homo sapiens	71-77
22271526-3	2012	Here, we report serum concentrations of the adrenal androgens dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) measured in 698 cross-sectional and mixed longitudinal serum samples from catarrhine primates ranging from 0.6 to 47 years of age.	Dehydroepiandrosterone Sulfate	96-126	sulfotransferase family 2A member 1	Homo sapiens	128-133
23095481-8	2012	The diagnoses were established based on progression of growth, bone age and serum levels of dehydroepiandrosterone sulfate (DHEAS), androstenedione, testosterone and 17-hydroxyprogesterone.	Dehydroepiandrosterone Sulfate	92-122	sulfotransferase family 2A member 1	Homo sapiens	124-129
22433179-1	2012	AIM: To investigate whether long-term exposure to the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces adaptive changes of GABA(A) receptors related to the development of tolerance and dependence.	Dehydroepiandrosterone Sulfate	67-97	sulfotransferase family 2A member 1	Homo sapiens	99-104
21790446-1	2012	Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are anabolic prehormones involved in the synthesis of testosterone.	Dehydroepiandrosterone Sulfate	34-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
22077213-1	2011	The interaction of testosterone, androsterone, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEAS) with erythrocyte membranes was studied.	Dehydroepiandrosterone Sulfate	82-112	sulfotransferase family 2A member 1	Homo sapiens	114-119
21251916-14	2011	We conclude that chronic treatment with nandrolone changes the affinity of the neurosteroids PS, 3alpha5betaS and DHEAS at the sigma-1 site but not at the sites on the sigma-2 receptor or the NMDA receptor subunit NR2B.	Dehydroepiandrosterone Sulfate	114-119	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	214-218
21900126-4	2011	Dehydroepiandrosterone sulfate (DHEAS) concentrations increased almost threefold (to 8 wk), dehydroepiandrosterone (DHEA) increased more than eightfold (to 11 wk), and androstenedione doubled (to 15 wk) in five castrated infant males and declined continuously thereafter.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
21384145-1	2011	The aim of this study was to confirm if there is a link between the alteration in blood levels of trace elements (chromium, copper, lead, cadmium, and zinc) and dehydroepiandrosterone sulfate (DHEAS) in healthy and diabetic states.	Dehydroepiandrosterone Sulfate	161-191	sulfotransferase family 2A member 1	Homo sapiens	193-198
21574166-2	2011	We previously showed that dehydroepiandrosterone sulfate (DHEAS) enhances zidovudine (AZT) transfer into syncytiotrophoblast.	Dehydroepiandrosterone Sulfate	26-56	sulfotransferase family 2A member 1	Homo sapiens	58-63
21908468-7	2011	An elevated dehydroepiandrosterone peak in response to ACTH, which defined functional adrenal hyperandrogenism, was similarly prevalent in PCOS-T (27.5%) and PCOS-A (30%) and correlated significantly with baseline dehydroepiandrosterone sulfate (DHEAS) (r = 0.708).	Dehydroepiandrosterone Sulfate	214-244	proopiomelanocortin	Homo sapiens	55-59
21908468-7	2011	An elevated dehydroepiandrosterone peak in response to ACTH, which defined functional adrenal hyperandrogenism, was similarly prevalent in PCOS-T (27.5%) and PCOS-A (30%) and correlated significantly with baseline dehydroepiandrosterone sulfate (DHEAS) (r = 0.708).	Dehydroepiandrosterone Sulfate	246-251	proopiomelanocortin	Homo sapiens	55-59
21839662-1	2011	BACKGROUND: Although insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone-sulfate (DHEA-S) are involved in age-related diseases such as cardiovascular disease and diabetes mellitus, the association of these hormones with serum adiponectin level is still unclear.	Dehydroepiandrosterone Sulfate	62-92	sulfotransferase family 2A member 1	Homo sapiens	94-100
21895860-1	2011	AIMS: Alterations in cortisol and dehydroepiandrosterone sulfate (DHEA-S) levels are thought to play a role in the pathophysiology of neuropsychiatric disorders, including schizophrenia.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-72
21752346-6	2011	Dehydroepiandrosterone sulfate showed a significant correlation with peak Vo2 (r = 0.29, p = 0.007), predicted peak Vo2 (r = 0.28, p = 0.006), and VE/Vco2 slope (r = -0.39, p &lt;0.001), whereas total testosterone, estimated free testosterone, and insulin-like growth factor-1 were not significantly correlated.	Dehydroepiandrosterone Sulfate	0-30	insulin like growth factor 1	Homo sapiens	248-276
21720737-2	2011	Therefore, we developed an ultra-performance LC-MS-MS method for high-throughput determination of concentrations of cortisol, cortisone, dehydroepiandrosterone (DHEA), and DHEA sulfate (DHEAS) in small quantities of human nails.	Dehydroepiandrosterone Sulfate	172-184	sulfotransferase family 2A member 1	Homo sapiens	186-191
21431424-8	2011	The day trip to the forest park significantly reduced blood pressure and urinary noradrenaline and dopamine levels and significantly increased serum adiponectin and dehydroepiandrosterone sulfate (DHEA-S) levels.	Dehydroepiandrosterone Sulfate	165-195	sulfotransferase family 2A member 1	Homo sapiens	197-203
21570195-1	2011	BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is important for its association with immune system function and health outcomes.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-49
21773816-0	2011	Higher DHEA-S (dehydroepiandrosterone sulfate) levels are associated with depressive symptoms during the menopausal transition: results from the PENN Ovarian Aging Study.	Dehydroepiandrosterone Sulfate	15-45	sulfotransferase family 2A member 1	Homo sapiens	7-13
21773816-2	2011	Because dehydroepiandrosterone sulfate (DHEA-S) has been associated with several indicators of healthy aging, we conducted a population-based study of midlife women to determine the relationship between DHEA-S levels and depressive symptoms and major depression during the transition through menopause.	Dehydroepiandrosterone Sulfate	8-38	sulfotransferase family 2A member 1	Homo sapiens	40-46
21789637-1	2011	Our aim was to examine the association between serum dehydroepiandrosterone sulfate (DHEAS) at baseline and BMD change at the femoral neck (FN) and lumbar spine (LS) in postmenopausal women during a 15-year follow-up.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	85-90
21533767-0	2011	Berberine cooperates with adrenal androgen dehydroepiandrosterone sulfate to attenuate PDGF-induced proliferation of vascular smooth muscle cell A7r5 through Skp2 signaling pathway.	Dehydroepiandrosterone Sulfate	43-73	S-phase kinase associated protein 2	Rattus norvegicus	158-162
21533767-9	2011	Berberine induces cell cycle arrest and potentiates the inhibitory effect of DHEAS through disrupting the binding of p27, p21 with Skp2.	Dehydroepiandrosterone Sulfate	77-82	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	117-120
21533767-9	2011	Berberine induces cell cycle arrest and potentiates the inhibitory effect of DHEAS through disrupting the binding of p27, p21 with Skp2.	Dehydroepiandrosterone Sulfate	77-82	KRAS proto-oncogene, GTPase	Rattus norvegicus	122-125
21533767-9	2011	Berberine induces cell cycle arrest and potentiates the inhibitory effect of DHEAS through disrupting the binding of p27, p21 with Skp2.	Dehydroepiandrosterone Sulfate	77-82	S-phase kinase associated protein 2	Rattus norvegicus	131-135
21533767-10	2011	Berberine and DHEAS decreased the expression of CDK2, CDK4, PCNA, cyclin D1, and cyclin E, which was induced by PDGF-BB.	Dehydroepiandrosterone Sulfate	14-19	cyclin dependent kinase 2	Rattus norvegicus	48-52
21533767-10	2011	Berberine and DHEAS decreased the expression of CDK2, CDK4, PCNA, cyclin D1, and cyclin E, which was induced by PDGF-BB.	Dehydroepiandrosterone Sulfate	14-19	cyclin-dependent kinase 4	Rattus norvegicus	54-58
21533767-10	2011	Berberine and DHEAS decreased the expression of CDK2, CDK4, PCNA, cyclin D1, and cyclin E, which was induced by PDGF-BB.	Dehydroepiandrosterone Sulfate	14-19	proliferating cell nuclear antigen	Rattus norvegicus	60-89
21533767-11	2011	Being treated with berberine and DHEAS also promoted p27 and p21 bind to CDK2, so the proliferation of A7r5 cells induced by PDGF-BB was inhibited.	Dehydroepiandrosterone Sulfate	33-38	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	53-56
21533767-11	2011	Being treated with berberine and DHEAS also promoted p27 and p21 bind to CDK2, so the proliferation of A7r5 cells induced by PDGF-BB was inhibited.	Dehydroepiandrosterone Sulfate	33-38	KRAS proto-oncogene, GTPase	Rattus norvegicus	61-64
21533767-11	2011	Being treated with berberine and DHEAS also promoted p27 and p21 bind to CDK2, so the proliferation of A7r5 cells induced by PDGF-BB was inhibited.	Dehydroepiandrosterone Sulfate	33-38	cyclin dependent kinase 2	Rattus norvegicus	73-77
21533767-12	2011	The data provide evidence that berberine acts through the inhibition of p27-Skp2 and p21-Skp2 with subsequent activation of the cell cycle arrest, which leads to the increase in sensitivity to DHEAS.	Dehydroepiandrosterone Sulfate	193-198	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	72-75
21533767-12	2011	The data provide evidence that berberine acts through the inhibition of p27-Skp2 and p21-Skp2 with subsequent activation of the cell cycle arrest, which leads to the increase in sensitivity to DHEAS.	Dehydroepiandrosterone Sulfate	193-198	KRAS proto-oncogene, GTPase	Rattus norvegicus	85-88
21533767-12	2011	The data provide evidence that berberine acts through the inhibition of p27-Skp2 and p21-Skp2 with subsequent activation of the cell cycle arrest, which leads to the increase in sensitivity to DHEAS.	Dehydroepiandrosterone Sulfate	193-198	S-phase kinase associated protein 2	Rattus norvegicus	89-93
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Dehydroepiandrosterone Sulfate	92-122	interleukin 1 alpha	Homo sapiens	5-14
21600230-5	2011	Both IL-1alpha and IL-1beta increased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate production, and the accumulation of mRNAs for steroidogenic acute regulatory protein (STAR), 17alpha-hydroxylase/17,20-lyase (CYP17A1) and 3beta-hydroxysteroid dehydrogenase 2 (HSD3B2) in these cells (P&lt;0.05 for all).	Dehydroepiandrosterone Sulfate	92-122	interleukin 1 beta	Homo sapiens	19-27
21772329-3	2011	RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women.	Dehydroepiandrosterone Sulfate	112-143	sulfotransferase family 2A member 1	Homo sapiens	145-150
21325432-0	2011	Organic anion transporter 3 mediates the efflux transport of an amphipathic organic anion, dehydroepiandrosterone sulfate, across the blood-brain barrier in mice.	Dehydroepiandrosterone Sulfate	91-121	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	0-27
21757861-7	2011	Efonidipine and nifedipine, but not other examined CCBs, also increased the N(6), 2"-O-dibutyryladenosine 3",5"-cyclic monophosphate (dbcAMP)-induced StAR mRNA, which reflects the action of adrenocorticotropic hormone, and efonidipine and R(-)-efonidipine enhanced the dbcAMP-induced DHEA-S production in NCI-H295R adrenocortical carcinoma cells.	Dehydroepiandrosterone Sulfate	284-290	steroidogenic acute regulatory protein	Homo sapiens	150-154
21257254-3	2011	Dehydroepiandrosterone sulphate (DHEA-S) is a corticotropin-dependent adrenal androgen precursor that is supressible in patients treated with ICS.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-39
21932174-2	2011	The aim of this work was to determine whether DHEA/DHEAS supplementation in differentiating C2C12 skeletal muscle cells might influence the expression of the atrophy-related ubiquitin ligase, MuRF-1, and thereby impact key molecules of the differentiation program.	Dehydroepiandrosterone Sulfate	51-56	tripartite motif-containing 63	Mus musculus	192-198
21932174-4	2011	However, our preliminary experiments showed that DHEAS, but not DHEA, is able to influence MuRF-1 expression.	Dehydroepiandrosterone Sulfate	49-54	tripartite motif-containing 63	Mus musculus	91-97
21932174-6	2011	We observed that DHEAS at physiological concentrations downregulates MuRF-1 expression and affects muscle differentiation, as shown by the increased levels of MHC, which is a sarcomeric protein that undergoes MuRF-1-dependent degradation, and also by an increase in creatine kinase activity and myogenin expression, which are two other well-known markers of differentiation.	Dehydroepiandrosterone Sulfate	17-22	tripartite motif-containing 63	Mus musculus	69-75
21932174-6	2011	We observed that DHEAS at physiological concentrations downregulates MuRF-1 expression and affects muscle differentiation, as shown by the increased levels of MHC, which is a sarcomeric protein that undergoes MuRF-1-dependent degradation, and also by an increase in creatine kinase activity and myogenin expression, which are two other well-known markers of differentiation.	Dehydroepiandrosterone Sulfate	17-22	tripartite motif-containing 63	Mus musculus	209-215
21932174-6	2011	We observed that DHEAS at physiological concentrations downregulates MuRF-1 expression and affects muscle differentiation, as shown by the increased levels of MHC, which is a sarcomeric protein that undergoes MuRF-1-dependent degradation, and also by an increase in creatine kinase activity and myogenin expression, which are two other well-known markers of differentiation.	Dehydroepiandrosterone Sulfate	17-22	myogenin	Mus musculus	295-303
21932174-7	2011	Moreover, we found that DHEAS might have a protective effect on differentiating cells as suggested by the augmented levels of Hsp70, a member of heat shock proteins family that, besides its cytoprotective action, seems to have a regulatory role on key atrophy genes such as MuRF-1.	Dehydroepiandrosterone Sulfate	24-29	heat shock protein 1B	Mus musculus	126-131
21932174-7	2011	Moreover, we found that DHEAS might have a protective effect on differentiating cells as suggested by the augmented levels of Hsp70, a member of heat shock proteins family that, besides its cytoprotective action, seems to have a regulatory role on key atrophy genes such as MuRF-1.	Dehydroepiandrosterone Sulfate	24-29	tripartite motif-containing 63	Mus musculus	274-280
21730243-6	2011	MAIN OUTCOME MEASURES: Plasma 17OHP and dehydroepiandrosterone-sulfate (DHEA-S) concentrations during the first week of treatment.	Dehydroepiandrosterone Sulfate	40-70	sulfotransferase family 2A member 1	Homo sapiens	72-78
21521261-2	2011	Pubarche is preceded by adrenarche - an increase in serum levels of adrenal androgens, most specifically dehydroepiandrosterone sulphate (DHEAS).	Dehydroepiandrosterone Sulfate	105-136	sulfotransferase family 2A member 1	Homo sapiens	138-143
22238751-0	2011	Contribution of dehydroepiandrosterone sulfate and progesterone to in vitro regulation of tolerogenic activity of IFN-alpha-induced dendritic cells.	Dehydroepiandrosterone Sulfate	16-46	interferon alpha 1	Homo sapiens	114-123
22238751-1	2011	Dehydroepiandrosterone sulfate and progesterone exhibited an immunomodulatory effect on the tolerogenic characteristics of IFN-alpha-induced dendritic cells.	Dehydroepiandrosterone Sulfate	0-30	interferon alpha 1	Homo sapiens	123-132
22238751-4	2011	The capacity of the hormones (dehydroepiandrosterone sulfate and progesterone) to attenuate tolerogenic activity of dendritic cells was associated with reduction of FasL expression on these cells, while the increase in tolerogenic activity was associated with the increase in the percentage of CD123(+) dendritic cells, and under conditions of modification with dehydroepiandrosterone sulfate it was associated with increased B7-H1 expression.	Dehydroepiandrosterone Sulfate	30-60	Fas ligand	Homo sapiens	165-169
22238751-5	2011	Possible contribution of indolamine-2,3-dioxygenase and prostaglandin E2 to stimulation of tolerogenic characteristics of dendritic cells modified with dehydroepiandrosterone sulfate and progesterone, respectively, was demonstrated.	Dehydroepiandrosterone Sulfate	152-182	indoleamine 2,3-dioxygenase 1	Homo sapiens	25-51
21325432-4	2011	Uptake of DHEAS and estrone-3-sulfate was greater in murine Oat3 cRNA-injected oocytes than that in water-injected oocytes.	Dehydroepiandrosterone Sulfate	10-15	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	60-64
21325432-6	2011	Furthermore, probenecid and taurocholate inhibited DHEAS efflux completely in Oat3(-/-) mice.	Dehydroepiandrosterone Sulfate	51-56	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	78-82
21325432-7	2011	Contrary to the past report in rats that suggested involvement of Oatp1a4, specific uptake of DHEAS and estrone-3-sulfate by murine Oatp1a4 was not detected in vitro, and efflux of both compounds from the brain was not altered in Oatp1a4(-/-) mice.	Dehydroepiandrosterone Sulfate	94-99	solute carrier organic anion transporter family, member 1a4	Mus musculus	132-139
21325432-7	2011	Contrary to the past report in rats that suggested involvement of Oatp1a4, specific uptake of DHEAS and estrone-3-sulfate by murine Oatp1a4 was not detected in vitro, and efflux of both compounds from the brain was not altered in Oatp1a4(-/-) mice.	Dehydroepiandrosterone Sulfate	94-99	solute carrier organic anion transporter family, member 1a4	Mus musculus	132-139
21325432-9	2011	Taken together, these results suggest that Oat3 plays a significant role in the efflux of steroid conjugates across the BBB in mice and that the BBB also expresses other unknown organic anion transporters for the efflux of DHEAS.	Dehydroepiandrosterone Sulfate	223-228	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	43-47
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Dehydroepiandrosterone Sulfate	128-158	steroid sulfatase	Homo sapiens	41-58
21356310-4	2011	One of the most promising targets is the steroid sulfatase (STS) which converts steroid sulfates like estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) to estrone (E1) and dehydroepiandrosterone (DHEA), respectively.	Dehydroepiandrosterone Sulfate	160-165	steroid sulfatase	Homo sapiens	41-58
21178790-1	2011	OBJECTIVE: A rise in circulating dehydroepiandrosterone sulfate (DHEAS) concentration occurs during the menopausal transition (MT) that is ovarian stage related but not age related.	Dehydroepiandrosterone Sulfate	33-63	sulfotransferase family 2A member 1	Homo sapiens	65-70
21525808-3	2011	MATERIAL/METHODS: The maternal and fetal serum levels of cortisol and dehydroepiandrosterone sulfate (DHEAS) were determined in 14 women with ICP and in pregnant rats with estrogen-induced intrahepatic cholestasis.	Dehydroepiandrosterone Sulfate	70-100	sulfotransferase family 2A member 1	Homo sapiens	102-107
21533175-1	2011	Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands--yet its function is unknown.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-38
21195131-7	2011	Dehydroepiandrosterone sulfate, similar to dehydroepiandrosterone, reduced nerve growth factor-induced neurite outgrowth of PC-12 cells and the expression of synaptosomal-associated membrane protein of 25 kDa, increased the expression of chromogranin A and significantly increased dopamine release of PC-12 cells.	Dehydroepiandrosterone Sulfate	0-30	chromogranin A	Rattus norvegicus	238-252
21195131-8	2011	In addition, dehydroepiandrosterone sulfate, dehydroepiandrosterone and membrane impermeable dehydroepiandrosterone-BSA all significantly reduced NGF-induced MAPK ERK1/2 signaling after 5 min.	Dehydroepiandrosterone Sulfate	13-43	mitogen activated protein kinase 3	Rattus norvegicus	158-162
21195131-8	2011	In addition, dehydroepiandrosterone sulfate, dehydroepiandrosterone and membrane impermeable dehydroepiandrosterone-BSA all significantly reduced NGF-induced MAPK ERK1/2 signaling after 5 min.	Dehydroepiandrosterone Sulfate	13-43	mitogen activated protein kinase 3	Rattus norvegicus	163-169
21143567-7	2011	In contrast, the low dehydroepiandrosterone sulfate (DHEA-S) tertile was associated with higher mortality risk in women (multivariate adjusted HR = 4.42, 95% CI = 1.51-12.90).	Dehydroepiandrosterone Sulfate	21-51	sulfotransferase family 2A member 1	Homo sapiens	53-59
21187059-5	2011	Our results indicate that hSULT2A1 forms non-productive ternary complexes that involve either DHEA or dehydroepiandrosterone sulfate, and the formation of these ternary complexes displays negative cooperativity in the binding of DHEA.	Dehydroepiandrosterone Sulfate	102-132	sulfotransferase family 2A member 1	Homo sapiens	26-34
21504661-1	2011	OBJECTIVES: The aim of this study was to compare serum dehydroepiandrosterone sulphate (DHEAS) levels and clinical and laboratory parameters reflecting expression of disease between female patients with primary Sjogren"s syndrome (pSS) and age-matched healthy women and to examine in pSS patients the correlation of these variables with fatigue, well-being, and functioning.	Dehydroepiandrosterone Sulfate	55-86	sulfotransferase family 2A member 1	Homo sapiens	88-93
21088016-2	2011	The current study aims to determine if dehydroepiandrosterone sulfate (DHEAS) level is associated with the presence of acne and reduced risk of abdominal obesity in women with PCOS, after considering the concurrent high testosterone level and insulin resistance (IR).	Dehydroepiandrosterone Sulfate	39-69	sulfotransferase family 2A member 1	Homo sapiens	71-76
21134877-5	2011	Measurements of baseline serum dehydroepiandrosterone sulfate (DHEA-S) levels are valuable in patients suspected of having adrenal insufficiency.	Dehydroepiandrosterone Sulfate	31-61	sulfotransferase family 2A member 1	Homo sapiens	63-69
21598681-1	2011	It had been shown that the blockade with dehydroepiandrosterone sulfate (DHEAS) affects enhanced aldosterone level in doses 1, 5 and 30 mg/kg without the dose dependence under multi-repeated cold exposure.	Dehydroepiandrosterone Sulfate	41-71	sulfotransferase family 2A member 1	Homo sapiens	73-78
21164255-1	2011	Adrenarche refers to the rise in adrenal 19- carbon steroid production, primarily dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	116-128	sulfotransferase family 2A member 1	Homo sapiens	130-135
22123283-1	2011	UNLABELLED: There have been only a few studies on adrenarche in girls with classic congenital adrenal hyperplasia (CAH) showing that dehydroepiandrosterone sulfate (DHEAS) levels did not rise at the physiological age of adrenarche.	Dehydroepiandrosterone Sulfate	133-163	sulfotransferase family 2A member 1	Homo sapiens	165-170
21841322-3	2011	In this study, we aimed to examine the clinical significance of serum DHEA sulfate (DHEAS) in patients with NAFLD.	Dehydroepiandrosterone Sulfate	70-82	sulfotransferase family 2A member 1	Homo sapiens	84-89
21876493-1	2011	OBJECTIVES: Dehydroepiandrosterone-sulphate (DHEAS) physiologic relevance remains controversial.	Dehydroepiandrosterone Sulfate	12-43	sulfotransferase family 2A member 1	Homo sapiens	45-50
22028893-17	2011	A low or normal basal plasma ACTH despite concomitant low cortisol at 8 a.m. and/or in spontaneous hypoglycemia, associated with low DHAS, in a patient not given corticosteroids is highly suggestive of ACTH deficiency.	Dehydroepiandrosterone Sulfate	133-137	proopiomelanocortin	Homo sapiens	29-33
22286784-13	2011	SHBG was related in group B to IGFBP-3, testosterone and to DHEAS.	Dehydroepiandrosterone Sulfate	60-65	sex hormone binding globulin	Homo sapiens	0-4
22286784-15	2011	The stepwise multiple regression revealed DHEAS and LH as predictors of IGF-I level in group A, while in group B none of the parameters predicted IGF-I level.	Dehydroepiandrosterone Sulfate	42-47	insulin like growth factor 1	Homo sapiens	72-77
20600171-0	2010	An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: involvement of the sigma-1 receptor.	Dehydroepiandrosterone Sulfate	22-52	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	115-118
21611153-5	2011	We found that no single nucleotide polymorphisms were associated with PCOS risk; however, the major allele of rs1569198 from DKK1 was associated with increased total testosterone (discovery cohort P = 0.0035) and dehydroepiandrosterone sulfate (replication cohort P = 0.05).	Dehydroepiandrosterone Sulfate	213-243	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	125-129
21708057-1	2010	Inhaled dehydroepiandrosterone-3-sulfate (DHEAS), but not dehydroepiandrosterone (DHEA), possesses anti-inflammatory activity in in vitro assays and in models of allergen and lipopolysaccharide challenges.	Dehydroepiandrosterone Sulfate	8-40	sulfotransferase family 2A member 1	Homo sapiens	42-47
20872786-4	2010	CRH also stimulates the fetal adrenal glands to produce dehydroepiandrostendione sulfate (DHEAS), which the placenta converts into estrogens.	Dehydroepiandrosterone Sulfate	90-95	corticoliberin	Saimiri boliviensis	0-3
20739385-1	2010	CONTEXT: Dehydroepiandrosterone sulfate (DHEA-S), a major circulating sex steroid prohormone, declines with age.	Dehydroepiandrosterone Sulfate	9-39	sulfotransferase family 2A member 1	Homo sapiens	41-47
20884032-7	2010	The serum adrenocorticotropic hormone level after androgen deprivation therapy was correlated with the serum levels of testosterone (p = 0.002), dehydroepiandrosterone sulfate (p = 0.002), androstenedione (p = 0.006) and prostate specific antigen (p &lt;0.001).	Dehydroepiandrosterone Sulfate	145-175	proopiomelanocortin	Homo sapiens	10-37
20884032-8	2010	Serum dehydroepiandrosterone sulfate and androstenedione levels were also correlated with serum prostate specific antigen (p &lt;0.001 and p = 0.002, respectively).	Dehydroepiandrosterone Sulfate	6-36	kallikrein related peptidase 3	Homo sapiens	96-121
20584122-2	2010	Androgens such as dehydroepiandrosterone sulfate (DHEA-S) and testosterone influence collagen metabolism by modulating the activity of matrix metalloproteases (MMP) and tissue inhibitors of metalloproteases (TIMP).	Dehydroepiandrosterone Sulfate	18-48	sulfotransferase family 2A member 1	Homo sapiens	50-56
20584122-2	2010	Androgens such as dehydroepiandrosterone sulfate (DHEA-S) and testosterone influence collagen metabolism by modulating the activity of matrix metalloproteases (MMP) and tissue inhibitors of metalloproteases (TIMP).	Dehydroepiandrosterone Sulfate	18-48	matrix metallopeptidase 1	Homo sapiens	160-163
20584122-2	2010	Androgens such as dehydroepiandrosterone sulfate (DHEA-S) and testosterone influence collagen metabolism by modulating the activity of matrix metalloproteases (MMP) and tissue inhibitors of metalloproteases (TIMP).	Dehydroepiandrosterone Sulfate	18-48	TIMP metallopeptidase inhibitor 1	Homo sapiens	169-206
20584122-2	2010	Androgens such as dehydroepiandrosterone sulfate (DHEA-S) and testosterone influence collagen metabolism by modulating the activity of matrix metalloproteases (MMP) and tissue inhibitors of metalloproteases (TIMP).	Dehydroepiandrosterone Sulfate	18-48	TIMP metallopeptidase inhibitor 1	Homo sapiens	208-212
20600171-0	2010	An increase in spinal dehydroepiandrosterone sulfate (DHEAS) enhances NMDA-induced pain via phosphorylation of the NR1 subunit in mice: involvement of the sigma-1 receptor.	Dehydroepiandrosterone Sulfate	54-59	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	115-118
20600171-9	2010	DHEAS also increased protein kinase C (PKC)- and protein kinase A (PKA)-dependent phosphorylation of the NMDA receptor subunit NR1 (pNR1), which was used as a marker of NMDA receptor sensitization.	Dehydroepiandrosterone Sulfate	0-5	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	127-130
20600171-10	2010	The sigma-1 receptor antagonist, BD-1047, but not the GABA(A) receptor agonist, muscimol, dose-dependently suppressed DHEAS"s facilitatory effect on NMDA-induced nociception and pNR1 expression.	Dehydroepiandrosterone Sulfate	118-123	sigma non-opioid intracellular receptor 1	Mus musculus	4-20
21112864-1	2010	OBJECTIVE: Dehydroepiandrosterone (DHEA) and Dehydroepiandrosterone-sulfate (DHEA-S) are the most abundant steroid hormones in the body.	Dehydroepiandrosterone Sulfate	45-75	sulfotransferase family 2A member 1	Homo sapiens	77-83
19395096-3	2010	OBJECTIVES: We studied the prevalence and prognostic consequences of deficiencies in circulating total and free testosterone (TT, FT) and dehydroepiandrosterone sulphate (DHEAS) in type II DM men with coronary artery disease (CAD).	Dehydroepiandrosterone Sulfate	138-169	sulfotransferase family 2A member 1	Homo sapiens	171-176
21268831-0	2010	[Selective influence of dehydroepiandrosterone-sulphate on anxiety induced by corticotropin-releasing hormone injection].	Dehydroepiandrosterone Sulfate	24-55	corticotropin releasing hormone	Rattus norvegicus	78-109
21268831-1	2010	The objective of this study was to ascertain the effect of dehydroepiandrosterone-sulphate (DHEA-S) on changes of anxiety level, induced by corticotropin-releasing hormone (CRH) injection.	Dehydroepiandrosterone Sulfate	59-90	corticotropin releasing hormone	Rattus norvegicus	140-171
21268831-1	2010	The objective of this study was to ascertain the effect of dehydroepiandrosterone-sulphate (DHEA-S) on changes of anxiety level, induced by corticotropin-releasing hormone (CRH) injection.	Dehydroepiandrosterone Sulfate	59-90	corticotropin releasing hormone	Rattus norvegicus	173-176
21268831-1	2010	The objective of this study was to ascertain the effect of dehydroepiandrosterone-sulphate (DHEA-S) on changes of anxiety level, induced by corticotropin-releasing hormone (CRH) injection.	Dehydroepiandrosterone Sulfate	92-98	corticotropin releasing hormone	Rattus norvegicus	140-171
21268831-1	2010	The objective of this study was to ascertain the effect of dehydroepiandrosterone-sulphate (DHEA-S) on changes of anxiety level, induced by corticotropin-releasing hormone (CRH) injection.	Dehydroepiandrosterone Sulfate	92-98	corticotropin releasing hormone	Rattus norvegicus	173-176
20687212-5	2010	After ADT, the serum PSA levels were correlated with each level of serum testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone-sulfate (DHEA-S), and 3alpha-diol G (P &lt; 0.010 in all).	Dehydroepiandrosterone Sulfate	125-155	kallikrein related peptidase 3	Homo sapiens	21-24
20627295-1	2010	BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is thought to be associated with life expectancy and anti-aging.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-49
20566621-6	2010	Additionally, higher serum dihydrotestosterone, dehydroepiandrosterone sulfate, androstenedione, and androstenetriol glucuronidate levels were correlated to greater insulin sensitivity.	Dehydroepiandrosterone Sulfate	48-78	insulin	Homo sapiens	165-172
20610590-3	2010	OBJECTIVES: We tested the hypothesis that low serum DHEA and DHEA sulfate (DHEA-S) levels predict all-cause and cardiovascular disease (CVD) death in elderly men.	Dehydroepiandrosterone Sulfate	61-73	sulfotransferase family 2A member 1	Homo sapiens	75-81
20466773-1	2010	INTRODUCTION: The correlation between dehydroepiandrosterone sulfate (DHEAS) decline and age led to the hypothesis that DHEAS might be a marker of primary aging, though conflicting data from observational studies of mortality do not support this.	Dehydroepiandrosterone Sulfate	38-68	sulfotransferase family 2A member 1	Homo sapiens	70-75
20466773-1	2010	INTRODUCTION: The correlation between dehydroepiandrosterone sulfate (DHEAS) decline and age led to the hypothesis that DHEAS might be a marker of primary aging, though conflicting data from observational studies of mortality do not support this.	Dehydroepiandrosterone Sulfate	38-68	sulfotransferase family 2A member 1	Homo sapiens	120-125
20519554-4	2010	Homovanillic acid, 5-hydroxyindole acetic acid, 2,4-dihydroxyphenylacetate, hippurate, and dehydroepiandrosterone sulfate (DHEAS) each significantly reduced mOat6 activity with inhibitory constant (K(i)) values of 3.0 +/- 0.5, 48.9 +/- 10.3, 61.4 +/- 7.1, 59.9 +/- 4.9, and 38.8 +/- 3.1 microM, respectively.	Dehydroepiandrosterone Sulfate	91-121	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	157-162
20519554-4	2010	Homovanillic acid, 5-hydroxyindole acetic acid, 2,4-dihydroxyphenylacetate, hippurate, and dehydroepiandrosterone sulfate (DHEAS) each significantly reduced mOat6 activity with inhibitory constant (K(i)) values of 3.0 +/- 0.5, 48.9 +/- 10.3, 61.4 +/- 7.1, 59.9 +/- 4.9, and 38.8 +/- 3.1 microM, respectively.	Dehydroepiandrosterone Sulfate	123-128	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	157-162
20519554-9	2010	Specifically, expression in Sertoli cells suggests Oat6 may be an important determinant of blood-testis barrier function, with Oat6-mediated transport of estrone sulfate and DHEAS possibly representing a critical step in the maintenance of testicular steroidogenesis.	Dehydroepiandrosterone Sulfate	174-179	solute carrier family 22 (organic anion transporter), member 20	Mus musculus	127-131
20505544-4	2010	RESULTS: In EA women, SULT1E1 variant carriers had lower levels of dehydroepiandrosterone sulfate, and SULT1A1 variant carriers had lower levels of estradiol, dehydroepiandrosterone sulfate, and testosterone compared with women who did not carry these variant alleles.	Dehydroepiandrosterone Sulfate	67-97	sulfotransferase family 1E member 1	Homo sapiens	22-29
20403346-5	2010	RESULTS: Subjects with the ACE gene D allele (higher ACE activity) had higher serum dehydroepiandrosterone (DHEA) sulphate and DHEA than those with I/I genotype (P=0.014 and 0.018 respectively, Mann Whitney test).	Dehydroepiandrosterone Sulfate	84-122	angiotensin I converting enzyme	Homo sapiens	27-30
20403346-5	2010	RESULTS: Subjects with the ACE gene D allele (higher ACE activity) had higher serum dehydroepiandrosterone (DHEA) sulphate and DHEA than those with I/I genotype (P=0.014 and 0.018 respectively, Mann Whitney test).	Dehydroepiandrosterone Sulfate	84-122	angiotensin I converting enzyme	Homo sapiens	53-56
20498139-1	2010	OBJECTIVES: The aim of the present analyses was to examine the association between cortisol, DHEA sulphate (DHEAS) and the cortisol:DHEAS ratio and mortality.	Dehydroepiandrosterone Sulfate	93-106	sulfotransferase family 2A member 1	Homo sapiens	108-113
20498139-1	2010	OBJECTIVES: The aim of the present analyses was to examine the association between cortisol, DHEA sulphate (DHEAS) and the cortisol:DHEAS ratio and mortality.	Dehydroepiandrosterone Sulfate	93-106	sulfotransferase family 2A member 1	Homo sapiens	132-137
20163485-1	2010	OBJECTIVES: To describe cross-sectional and longitudinal associations with dehydroepiandrosterone sulfate (DHEAS) and change in DHEAS with age.	Dehydroepiandrosterone Sulfate	75-105	sulfotransferase family 2A member 1	Homo sapiens	107-112
20178799-1	2010	The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate.	Dehydroepiandrosterone Sulfate	203-233	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	4-45
20178799-1	2010	The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate.	Dehydroepiandrosterone Sulfate	203-233	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	47-51
20178799-1	2010	The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate.	Dehydroepiandrosterone Sulfate	203-233	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	52-57
20178799-1	2010	The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate.	Dehydroepiandrosterone Sulfate	235-240	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	4-45
20178799-1	2010	The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate.	Dehydroepiandrosterone Sulfate	235-240	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	47-51
20178799-1	2010	The multidrug resistance-associated protein 1 (MRP1/ABCC1) is a member of the ABC active transporter family that can transport several steroid hormone conjugates, including 17beta-estradiol glucuronide, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate.	Dehydroepiandrosterone Sulfate	235-240	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	52-57
20649839-2	2010	The present results demonstrate that [(3)H]DHEAS and [(3)H]PREGS are relatively high affinity substrates for the organic solute transporter, OSTalpha-OSTbeta, and that the two proteins that constitute this transporter are selectively localized to steroidogenic cells in the cerebellum and hippocampus, namely the Purkinje cells and cells in the cornu ammonis region in both mouse and human brain.	Dehydroepiandrosterone Sulfate	43-48	solute carrier family 51, alpha subunit	Mus musculus	141-149
20649839-2	2010	The present results demonstrate that [(3)H]DHEAS and [(3)H]PREGS are relatively high affinity substrates for the organic solute transporter, OSTalpha-OSTbeta, and that the two proteins that constitute this transporter are selectively localized to steroidogenic cells in the cerebellum and hippocampus, namely the Purkinje cells and cells in the cornu ammonis region in both mouse and human brain.	Dehydroepiandrosterone Sulfate	43-48	solute carrier family 51 subunit beta	Homo sapiens	150-157
20649839-4	2010	In addition, Ostalpha-deficient mice exhibited changes in serum DHEA and DHEAS levels, and in tissue distribution of administered [(3)H]DHEAS.	Dehydroepiandrosterone Sulfate	73-78	solute carrier family 51, alpha subunit	Mus musculus	13-21
20649839-4	2010	In addition, Ostalpha-deficient mice exhibited changes in serum DHEA and DHEAS levels, and in tissue distribution of administered [(3)H]DHEAS.	Dehydroepiandrosterone Sulfate	136-141	solute carrier family 51, alpha subunit	Mus musculus	13-21
20649839-5	2010	OSTalpha and OSTbeta proteins were also localized to the zona reticularis of human adrenal gland, the major region for DHEAS production in the periphery.	Dehydroepiandrosterone Sulfate	119-124	solute carrier family 51 subunit alpha	Homo sapiens	0-8
20649839-5	2010	OSTalpha and OSTbeta proteins were also localized to the zona reticularis of human adrenal gland, the major region for DHEAS production in the periphery.	Dehydroepiandrosterone Sulfate	119-124	solute carrier family 51 subunit beta	Homo sapiens	13-20
20649839-6	2010	These results demonstrate that OSTalpha-OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and that it modulates DHEA/DHEAS homeostasis, suggesting that it may contribute to neurosteroid action.	Dehydroepiandrosterone Sulfate	143-148	solute carrier family 51, alpha subunit	Mus musculus	31-39
20649839-6	2010	These results demonstrate that OSTalpha-OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and that it modulates DHEA/DHEAS homeostasis, suggesting that it may contribute to neurosteroid action.	Dehydroepiandrosterone Sulfate	143-148	solute carrier family 51, beta subunit	Mus musculus	40-47
20399839-2	2010	Therefore, the rationale of this positron emission tomography (PET) study was to investigate the influence of the 5-HT(1A) receptor distribution in the human brain on plasma levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol in vivo.	Dehydroepiandrosterone Sulfate	184-214	5-hydroxytryptamine receptor 1A	Homo sapiens	114-131
20399839-10	2010	In conclusion, the serotonergic system may influence the DHEAS plasma level by modulating CRH and ACTH release via hypothalamic 5-HT(1A) receptors as reported for cortisol before.	Dehydroepiandrosterone Sulfate	57-62	corticotropin releasing hormone	Homo sapiens	90-93
19863577-10	2010	Median serum dehydroepiandrosterone sulphate (DHEAS) was 2.1 and 4.1 mumol/l, androstenedione 3.1 and 3.8 nmol/l in girls and boys respectively, with DHEAS within the reference range/undetectable in 18/2 and androstenedione in 12/6 patients.	Dehydroepiandrosterone Sulfate	13-44	sulfotransferase family 2A member 1	Homo sapiens	46-51
20139233-1	2010	CONTEXT: Although age-related declines in dehydroepiandrosterone sulfate (DHEAS) and testosterone are associated with cardiovascular risk, it remains to be determined whether replacement of these hormones improves cardiovascular risk factors.	Dehydroepiandrosterone Sulfate	42-72	sulfotransferase family 2A member 1	Homo sapiens	74-79
20172962-1	2010	Dehydroepiandrosterone sulfate (DHEAS) is the most abundant steroid in the human circulation and is secreted by the adrenals in an age-dependent fashion, with maximum levels during the third decade and very low levels in old age.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
19995565-12	2010	The sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate also stimulated a 2.1-fold increase in the level of Ser473-phosphorylated Akt-1.	Dehydroepiandrosterone Sulfate	54-67	sigma non-opioid intracellular receptor 1	Rattus norvegicus	4-20
19995565-0	2010	Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells.	Dehydroepiandrosterone Sulfate	66-79	sigma non-opioid intracellular receptor 1	Rattus norvegicus	16-32
19995565-0	2010	Fluvoxamine and sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate induces the Ser473-phosphorylation of Akt-1 in PC12 cells.	Dehydroepiandrosterone Sulfate	66-79	AKT serine/threonine kinase 1	Rattus norvegicus	118-123
19226405-3	2010	In this study, we sought to investigate the relationship between hepatic steatosis, serum testosterone and dehydroepiandrosterone sulphate (DHEAS) levels in men.	Dehydroepiandrosterone Sulfate	107-138	sulfotransferase family 2A member 1	Homo sapiens	140-145
19995565-12	2010	The sigma-1 receptor agonists dehydroepiandrosterone (DHEA)-sulfate also stimulated a 2.1-fold increase in the level of Ser473-phosphorylated Akt-1.	Dehydroepiandrosterone Sulfate	54-67	AKT serine/threonine kinase 1	Rattus norvegicus	142-147
20518188-1	2010	Aging process is accompanied by hormonal changes characterized by an imbalance between catabolic hormones that remain stable and anabolic hormones (testosterone, insulin like growth factor-1 (IGF-1) and dehydroepiandrosterone sulphate (DHEAS), that decrease with age.	Dehydroepiandrosterone Sulfate	203-234	sulfotransferase family 2A member 1	Homo sapiens	236-241
19562343-2	2010	The secondary objectives were as follows: to describe demographic and clinical characteristics of male patients with FM; to evaluate basal levels of dehydroepiandrosterone sulfate (DHEAS) and total testosterone in both groups; and to investigate the relationship among pain, tender points, anxiety, and depression in these patients.	Dehydroepiandrosterone Sulfate	149-179	sulfotransferase family 2A member 1	Homo sapiens	181-186
19497978-2	2009	Cholesterol side-chain cleavage (CYP11A1) and 17alpha-hydroxylase/17,20-lyase (CYP17) metabolize cholesterol into DHEA, whereas steroid sulfotransferase family 2A1 (SULT2A1) is responsible for conversion of DHEA to DHEA sulfate.	Dehydroepiandrosterone Sulfate	215-227	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	33-40
19627466-2	2009	Together with its sulfate version, DHEA-sulfate (DHEAS), it is the most abundant steroid in humans.	Dehydroepiandrosterone Sulfate	35-47	sulfotransferase family 2A member 1	Homo sapiens	49-54
19298964-5	2009	In vitro, DHEAS exhibited inhibitory effects on VSMC proliferation and migration activities, inducing G1 cell cycle arrest with upregulation of one of the cyclin dependent kinase (CDK) inhibitors p16(INK4a) and apoptosis with activating peroxisome proliferator-activated receptor (PPAR)-alpha in VSMCs.	Dehydroepiandrosterone Sulfate	10-15	peroxisome proliferator-activated receptor alpha	Oryctolagus cuniculus	237-292
19298964-6	2009	DHEAS inhibits vascular remodeling reducing neointima formation after vascular injury via its effects on VSMC phenotypic modulation, functions and apoptosis upregulating p16(INK4a)/activating PPARalpha.	Dehydroepiandrosterone Sulfate	0-5	peroxisome proliferator-activated receptor alpha	Oryctolagus cuniculus	192-201
20963561-0	2010	Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome.	Dehydroepiandrosterone Sulfate	41-47	nuclear receptor subfamily 3 group C member 1	Homo sapiens	60-83
19713299-1	2009	BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) has been proposed as an antiaging hormone, but its importance is unclear.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-49
19594690-3	2009	However, it has been reported that levels of the steroid dehydroepiandrosterone sulphate (DHEAS) are reduced in plasma of patients with PBC, and substitutive therapy has been suggested to improve fatigue symptoms experienced during the course of this disease.	Dehydroepiandrosterone Sulfate	57-88	sulfotransferase family 2A member 1	Homo sapiens	90-95
19594690-9	2009	Dehydroepiandrosterone sulphate treatment was sufficient to increase brain levels of DHEAS in the BDL rats in a manner that is significantly and highly correlated with those of plasma DHEAS and brain dehydroepiandrosterone (DHEA).	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	85-90
19594690-9	2009	Dehydroepiandrosterone sulphate treatment was sufficient to increase brain levels of DHEAS in the BDL rats in a manner that is significantly and highly correlated with those of plasma DHEAS and brain dehydroepiandrosterone (DHEA).	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	184-189
19732820-0	2009	Lack of association between plasma dehydroepiandrosterone sulfate (DHEA-S) levels and depression in hemodialysis patients: a cross-sectional study.	Dehydroepiandrosterone Sulfate	35-65	sulfotransferase family 2A member 1	Homo sapiens	67-73
19595697-1	2009	The steroid dehydroepiandrosterone sulfate (DHEA-S) is associated with longevity and adaptation against external stress in humans.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-50
20218317-4	2009	RESULTS: The level of serum PSA was found to be significantly higher in the hyperandrogenism patients than in the healthy controls (9.72 +/- 1.39 pg/ml vs 3.56 +/- 0.44 pg/ml, P &lt; 0.01), and it showed a weak positive correlation with T (r = 0.226, P &lt; 0.05) and DHEA-S (r = 0.255, P &lt; 0.05), and a weak negative correlation with SHBG (r = -0,228, P &lt; 0.05).	Dehydroepiandrosterone Sulfate	268-274	kallikrein related peptidase 3	Homo sapiens	28-31
19646552-0	2009	Oral administration of dehydroepiandrosterone-sulfate (DHEAS) increases in vitro lymphocyte function and improves in vivo response of pigs to immunization against keyhole limpet hemocyanin (KLH) and ovalbumin.	Dehydroepiandrosterone Sulfate	23-53	ovalbumin	Sus scrofa	199-208
19646552-0	2009	Oral administration of dehydroepiandrosterone-sulfate (DHEAS) increases in vitro lymphocyte function and improves in vivo response of pigs to immunization against keyhole limpet hemocyanin (KLH) and ovalbumin.	Dehydroepiandrosterone Sulfate	55-60	ovalbumin	Sus scrofa	199-208
19497978-2	2009	Cholesterol side-chain cleavage (CYP11A1) and 17alpha-hydroxylase/17,20-lyase (CYP17) metabolize cholesterol into DHEA, whereas steroid sulfotransferase family 2A1 (SULT2A1) is responsible for conversion of DHEA to DHEA sulfate.	Dehydroepiandrosterone Sulfate	215-227	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	79-84
19497978-2	2009	Cholesterol side-chain cleavage (CYP11A1) and 17alpha-hydroxylase/17,20-lyase (CYP17) metabolize cholesterol into DHEA, whereas steroid sulfotransferase family 2A1 (SULT2A1) is responsible for conversion of DHEA to DHEA sulfate.	Dehydroepiandrosterone Sulfate	215-227	sulfotransferase family 2A member 1	Homo sapiens	136-163
19470626-1	2009	CONTEXT: A previous report from the Study of Women Across the Nation indicated a rise in dehydroepiandrosterone sulfate (DHEAS) during the menopausal transition using data from three annual visits.	Dehydroepiandrosterone Sulfate	89-119	sulfotransferase family 2A member 1	Homo sapiens	121-126
19420298-5	2009	Further study showed that DHEAS inhibited the 5-HT(3) receptor agonist evoked-glutamate release but had no effect on the 5-HT(2A/2C) receptor agonist-evoked release.	Dehydroepiandrosterone Sulfate	26-31	5-hydroxytryptamine receptor 3A	Rattus norvegicus	46-62
19420298-6	2009	Moreover, the 5-HT(3) receptor antagonist could block the effect of DHEAS on the 5-HT-evoked glutamate release.	Dehydroepiandrosterone Sulfate	68-73	5-hydroxytryptamine receptor 3A	Rattus norvegicus	14-30
19420298-7	2009	The mechanism study showed that the sigma-1 receptor antagonist could block the effect of DHEAS and that the sigma-1 receptor agonist could mimic the effect of DHEAS on 5-HT(3) receptor agonist-evoked glutamate release and intrasynaptosomal Ca(2+) increase.	Dehydroepiandrosterone Sulfate	90-95	sigma non-opioid intracellular receptor 1	Rattus norvegicus	36-52
19420298-7	2009	The mechanism study showed that the sigma-1 receptor antagonist could block the effect of DHEAS and that the sigma-1 receptor agonist could mimic the effect of DHEAS on 5-HT(3) receptor agonist-evoked glutamate release and intrasynaptosomal Ca(2+) increase.	Dehydroepiandrosterone Sulfate	160-165	sigma non-opioid intracellular receptor 1	Rattus norvegicus	109-125
19420298-7	2009	The mechanism study showed that the sigma-1 receptor antagonist could block the effect of DHEAS and that the sigma-1 receptor agonist could mimic the effect of DHEAS on 5-HT(3) receptor agonist-evoked glutamate release and intrasynaptosomal Ca(2+) increase.	Dehydroepiandrosterone Sulfate	160-165	5-hydroxytryptamine receptor 3A	Rattus norvegicus	169-185
19420298-8	2009	These results suggest that DHEAS can inhibit 5-HT-evoked glutamate release via activation of the sigma-1 receptor and then inhibition of the 5-HT(3) receptor in the pyramidal cells of the prelimbic cortex.	Dehydroepiandrosterone Sulfate	27-32	sigma non-opioid intracellular receptor 1	Rattus norvegicus	97-113
19420298-8	2009	These results suggest that DHEAS can inhibit 5-HT-evoked glutamate release via activation of the sigma-1 receptor and then inhibition of the 5-HT(3) receptor in the pyramidal cells of the prelimbic cortex.	Dehydroepiandrosterone Sulfate	27-32	5-hydroxytryptamine receptor 3A	Rattus norvegicus	141-157
19902100-2	2009	Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-alpha-induced dendritic cell, which manifested in a decrease in the number of CD14(+)cells and increase in the ratio of mature CD83(+)dendritic cells expressing costimulatory molecules (CD80 and CD86).	Dehydroepiandrosterone Sulfate	0-30	CD14 molecule	Homo sapiens	165-169
19902100-2	2009	Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-alpha-induced dendritic cell, which manifested in a decrease in the number of CD14(+)cells and increase in the ratio of mature CD83(+)dendritic cells expressing costimulatory molecules (CD80 and CD86).	Dehydroepiandrosterone Sulfate	0-30	CD83 molecule	Homo sapiens	214-218
19902100-2	2009	Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-alpha-induced dendritic cell, which manifested in a decrease in the number of CD14(+)cells and increase in the ratio of mature CD83(+)dendritic cells expressing costimulatory molecules (CD80 and CD86).	Dehydroepiandrosterone Sulfate	0-30	CD80 molecule	Homo sapiens	273-277
19902100-2	2009	Dehydroepiandrosterone sulfate stimulated differentiation and maturation of interferon-alpha-induced dendritic cell, which manifested in a decrease in the number of CD14(+)cells and increase in the ratio of mature CD83(+)dendritic cells expressing costimulatory molecules (CD80 and CD86).	Dehydroepiandrosterone Sulfate	0-30	CD86 molecule	Homo sapiens	282-286
19902100-3	2009	The induction of dendritic cell differentiation after treatment with dehydroepiandrosterone sulfate was accompanied by an increase in the production of interferon-gamma.	Dehydroepiandrosterone Sulfate	69-99	interferon gamma	Homo sapiens	152-168
19902100-4	2009	At the stage of dendritic cell maturation, the effect of dehydroepiandrosterone sulfate manifested in a 4-fold increase in tumor necrosis factor-alpha production.	Dehydroepiandrosterone Sulfate	57-87	tumor necrosis factor	Homo sapiens	123-150
19902100-6	2009	Dehydroepiandrosterone sulfate increased the ability of dendritic cells to stimulate Th1 cytokine production by T cells (interferon-gamma).	Dehydroepiandrosterone Sulfate	0-30	negative elongation factor complex member C/D	Homo sapiens	85-88
19902100-6	2009	Dehydroepiandrosterone sulfate increased the ability of dendritic cells to stimulate Th1 cytokine production by T cells (interferon-gamma).	Dehydroepiandrosterone Sulfate	0-30	interferon gamma	Homo sapiens	121-137
19022340-6	2009	In NGF-stimulated cells, neuronal differentiation was inhibited by DHEA-S, as demonstrated by a 22% reduction (n=3; p&lt;0.05) of neuronal differentiation marker expression, synaptosome-associated protein of 25kDa (SNAP-25), and a 59% (n=6; p&lt;0.001) decrease in neurite outgrowth.	Dehydroepiandrosterone Sulfate	67-73	synaptosome associated protein 25	Rattus norvegicus	174-213
19592278-8	2009	Initial bloodwork documented extremely high levels of free testosterone (117 pmol/L) and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	89-119	sulfotransferase family 2A member 1	Homo sapiens	121-126
19342396-10	2009	In multivariate regression analyses, AMH associated positively with testosterone P = 0.004), and negatively with dehydroepiandrosterone sulphate (DHEAS) (P = 0.001) and C-peptide levels (P = 0.020).	Dehydroepiandrosterone Sulfate	113-144	anti-Mullerian hormone	Homo sapiens	37-40
19342396-10	2009	In multivariate regression analyses, AMH associated positively with testosterone P = 0.004), and negatively with dehydroepiandrosterone sulphate (DHEAS) (P = 0.001) and C-peptide levels (P = 0.020).	Dehydroepiandrosterone Sulfate	113-144	sulfotransferase family 2A member 1	Homo sapiens	146-151
19422393-8	2009	Moreover, this DHEAS-induced mechanical allodynia was significantly reduced by administration of the sigma-1 receptor antagonist, BD-1047 or the GABA(A) receptor agonist, muscimol.	Dehydroepiandrosterone Sulfate	15-20	sigma non-opioid intracellular receptor 1	Mus musculus	101-117
18554595-0	2009	Effect of sex steroids and insulin on dehydroepiandrosterone sulfate production by hepatoma G2 cells.	Dehydroepiandrosterone Sulfate	38-68	insulin	Homo sapiens	27-34
19158194-7	2009	We found RBP4 serum concentrations at baseline to be positively correlated with serum levels of testosterone (R = 0.446; P = 0.005), 17-OH progesterone (R = 0.345, P = 0.037), and dehydroepiandrosterone sulfate (R = 0.347; P = 0.041).	Dehydroepiandrosterone Sulfate	180-210	retinol binding protein 4	Homo sapiens	9-13
19303967-7	2009	In univariate analysis, RBP4 was associated with follicle-stimulating hormone (r = 0.37, P = .0004), luteinizing hormone (r = 0.3, P = .005), and sex hormone-binding globulin (r = -0.24, P = .03) and trended to significance with estradiol (P = .09) but not with free testosterone or dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	283-313	retinol binding protein 4	Homo sapiens	24-28
19022340-6	2009	In NGF-stimulated cells, neuronal differentiation was inhibited by DHEA-S, as demonstrated by a 22% reduction (n=3; p&lt;0.05) of neuronal differentiation marker expression, synaptosome-associated protein of 25kDa (SNAP-25), and a 59% (n=6; p&lt;0.001) decrease in neurite outgrowth.	Dehydroepiandrosterone Sulfate	67-73	synaptosome associated protein 25	Rattus norvegicus	215-222
19022340-7	2009	Moreover, DHEA-S stimulated expression of endocrine marker chromogranin A (CgA) by 31% (n=4; p&lt;0.05 vs. control) and catecholamine release from NGF-treated PC12 cells by 229% (n=3-5; p&lt;0.001), indicating a DHEA-S-induced shift towards neuroendocrine differentiation.	Dehydroepiandrosterone Sulfate	10-16	chromogranin A	Rattus norvegicus	59-73
19022340-7	2009	Moreover, DHEA-S stimulated expression of endocrine marker chromogranin A (CgA) by 31% (n=4; p&lt;0.05 vs. control) and catecholamine release from NGF-treated PC12 cells by 229% (n=3-5; p&lt;0.001), indicating a DHEA-S-induced shift towards neuroendocrine differentiation.	Dehydroepiandrosterone Sulfate	10-16	chromogranin A	Rattus norvegicus	75-78
19022340-8	2009	On a molecular level, DHEA-S diminished NGF-induced ERK1/2 phosphorylation.	Dehydroepiandrosterone Sulfate	22-28	mitogen activated protein kinase 3	Rattus norvegicus	52-58
19022340-10	2009	Interference of DHEA-S with NGF-stimulated ERK1/2 activation might be involved in this effect.	Dehydroepiandrosterone Sulfate	16-22	mitogen activated protein kinase 3	Rattus norvegicus	43-49
19289327-1	2009	OBJECTIVE: To report a case of hyperandrogenism attributable to the presence of an adrenal adenoma secreting dehydroepiandrosterone sulfate (DHEA-S) and an ovarian Sertoli-Leydig cell tumor secreting testosterone in a postmenopausal woman.	Dehydroepiandrosterone Sulfate	109-139	sulfotransferase family 2A member 1	Homo sapiens	141-147
19347710-1	2009	OBJECTIVE: To determine the effect of serum androgens [testosterone and dehydroepiandrosterone sulphate (DHEAS)] on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes.	Dehydroepiandrosterone Sulfate	72-103	sulfotransferase family 2A member 1	Homo sapiens	105-110
19836631-0	2009	Growth factors decrease in subjects with mild to moderate Alzheimer"s disease (AD): potential correction with dehydroepiandrosterone-sulphate (DHEAS).	Dehydroepiandrosterone Sulfate	110-141	sulfotransferase family 2A member 1	Homo sapiens	143-148
18706658-1	2009	BACKGROUND: Among the neuroactive steroids, dehydroepiandrosterone sulfate (DHEA-S) is at least in part produced in the adrenal gland and is therefore under the control of the hypothalamic-pituitary-adrenocortical (HPA)-system.	Dehydroepiandrosterone Sulfate	44-74	sulfotransferase family 2A member 1	Homo sapiens	76-82
18727654-2	2008	In this study, we examined the association between levels of the stress-related steroid hormones cortisol and dehydroepiandrosterone-sulphate (DHEAS) and periodontitis in elderly subjects.	Dehydroepiandrosterone Sulfate	110-141	sulfotransferase family 2A member 1	Homo sapiens	143-148
19156586-1	2009	Several lines of evidence suggest that dehydroepiandrosterone sulphate (DHEA-S) is invariably consumed following different types of acute stress, implicating its role in stress coping and recovery.	Dehydroepiandrosterone Sulfate	39-70	sulfotransferase family 2A member 1	Homo sapiens	72-78
18796549-5	2008	LIF treatment augmented cortisol, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione, and aldosterone production (up to 224, 211, 149, 229, and 170% of control respectively, P&lt;0.05 for all).	Dehydroepiandrosterone Sulfate	65-77	LIF interleukin 6 family cytokine	Homo sapiens	0-3
19161105-4	2008	The severity of bacterial peritonitis in liver cirrhosis was significantly associated with enhanced serum IL-6 and cortisol levels, and a decrease in serum DHEA sulfate in relation to serum IL-6 concentrations.	Dehydroepiandrosterone Sulfate	156-168	interleukin 6	Homo sapiens	190-194
18485675-8	2008	We observed lower serum dehydroepiandrosterone sulfate (DHEA-S) concentration in patients with chronic urticaria with positive and negative response to autologous serum skin test.	Dehydroepiandrosterone Sulfate	24-54	sulfotransferase family 2A member 1	Homo sapiens	56-62
18419789-0	2008	Relationship between calcium absorption and plasma dehydroepiandrosterone sulphate (DHEAS) in healthy males.	Dehydroepiandrosterone Sulfate	51-82	sulfotransferase family 2A member 1	Homo sapiens	84-89
18422949-1	2008	OBJECTIVES: To determine whether serum dehydroepiandrosterone sulfate (DHEAS) levels could predict longevity in residents.	Dehydroepiandrosterone Sulfate	39-69	sulfotransferase family 2A member 1	Homo sapiens	71-76
18547670-4	2008	Dehydroepiandrosterone sulfate (DHEA-S) is known to protect against articular cartilage loss.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-38
18493102-1	2008	We investigated the relationship between serum dehydroepiandrosterone-sulfate (DHEA-S) and insulin-like growth factor-I (IGF-I) to various parameters for atherosclerosis in type 2 diabetes.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-85
18596927-8	2008	Fluvoxamine (but not sertraline or paroxetine) and the sigma-1 receptor agonists SA4503, PPBP, and DHEA-sulfate significantly potentiated NGF-induced neurite outgrowth in PC12 cells in a concentration-dependent manner.	Dehydroepiandrosterone Sulfate	99-111	sigma non-opioid intracellular receptor 1	Rattus norvegicus	55-71
18596927-8	2008	Fluvoxamine (but not sertraline or paroxetine) and the sigma-1 receptor agonists SA4503, PPBP, and DHEA-sulfate significantly potentiated NGF-induced neurite outgrowth in PC12 cells in a concentration-dependent manner.	Dehydroepiandrosterone Sulfate	99-111	nerve growth factor	Rattus norvegicus	138-141
18953090-5	2008	It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM).	Dehydroepiandrosterone Sulfate	51-56	mitogen-activated protein kinase 1	Homo sapiens	126-163
18953090-5	2008	It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM).	Dehydroepiandrosterone Sulfate	51-56	mitogen-activated protein kinase 1	Homo sapiens	165-168
18953090-5	2008	It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM).	Dehydroepiandrosterone Sulfate	51-56	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	253-282
18308813-4	2008	The effect on behavioural despair by DHEAS (10 and 40 mg/kg, s.c.) and PS (40 mg/kg, s.c.) was blocked by BD 1047 (1 mg/kg, s.c.), a novel sigma1-receptor antagonist, progesterone (10 mg/kg, s.c.), a sigma-receptor antagonistic neurosteroid or rimcazole (5 mg/kg, s.c.), another sigma1-receptor antagonistic property, respectively.	Dehydroepiandrosterone Sulfate	37-42	sigma non-opioid intracellular receptor 1	Mus musculus	139-154
18308813-4	2008	The effect on behavioural despair by DHEAS (10 and 40 mg/kg, s.c.) and PS (40 mg/kg, s.c.) was blocked by BD 1047 (1 mg/kg, s.c.), a novel sigma1-receptor antagonist, progesterone (10 mg/kg, s.c.), a sigma-receptor antagonistic neurosteroid or rimcazole (5 mg/kg, s.c.), another sigma1-receptor antagonistic property, respectively.	Dehydroepiandrosterone Sulfate	37-42	sigma non-opioid intracellular receptor 1	Mus musculus	279-294
18645714-6	2008	Furthermore, we correlated the AR (CAG)(n) with serum testosterone, androstenedione, dehydroepiandrosterone sulfate and several parameters of glucose and lipid metabolism in each group and in all 121 women.	Dehydroepiandrosterone Sulfate	85-115	androgen receptor	Homo sapiens	31-33
18445661-0	2008	Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome.	Dehydroepiandrosterone Sulfate	35-65	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	15-21
18606731-1	2008	OBJECTIVE: Dehydroepiandrosterone sulfate (DHEA-S) decline in chronic urticaria (CU) may be involved in etiopathogenesis of the disease or is a secondary phenomenon resulting e.g. from psychological distress.	Dehydroepiandrosterone Sulfate	11-41	sulfotransferase family 2A member 1	Homo sapiens	43-49
18414001-4	2008	Among OATs, hOAT4 mediates high affinity transport of estrone sulfate and dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	74-104	solute carrier family 22 member 11	Homo sapiens	12-17
18234363-1	2008	The secretion of dehydroepiandrosterone sulfate (DHEAS) decreases with age, and the incidence of heart failure rises in the elderly population.	Dehydroepiandrosterone Sulfate	17-47	sulfotransferase family 2A member 1	Homo sapiens	49-54
18035354-5	2008	The effect of dehydroepiandrosterone sulphate on persistent sodium currents was also canceled by the sigma-1 receptor blockers and the sigma-1 receptor agonist could mimic the effect of dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	14-45	sigma non-opioid intracellular receptor 1	Rattus norvegicus	101-117
18035354-5	2008	The effect of dehydroepiandrosterone sulphate on persistent sodium currents was also canceled by the sigma-1 receptor blockers and the sigma-1 receptor agonist could mimic the effect of dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	14-45	sigma non-opioid intracellular receptor 1	Rattus norvegicus	135-151
18035354-5	2008	The effect of dehydroepiandrosterone sulphate on persistent sodium currents was also canceled by the sigma-1 receptor blockers and the sigma-1 receptor agonist could mimic the effect of dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	186-217	sigma non-opioid intracellular receptor 1	Rattus norvegicus	135-151
18073302-1	2008	CONTEXT: It has been proposed that dehydroepiandrosterone and dehydroepiandrosterone sulfate (DHEAS) exert neuroprotective effects in the brain, yet evidence of associations between the endogenous levels of these steroids and measures of cognitive function is lacking.	Dehydroepiandrosterone Sulfate	62-92	sulfotransferase family 2A member 1	Homo sapiens	94-99
18310376-2	2008	The stress hormones dehydroepiandrosterone sulfate (DHEAS) and cortisol have opposing effects: cortisol suppresses while DHEAS enhances immune functions.	Dehydroepiandrosterone Sulfate	20-50	sulfotransferase family 2A member 1	Homo sapiens	52-57
18310376-2	2008	The stress hormones dehydroepiandrosterone sulfate (DHEAS) and cortisol have opposing effects: cortisol suppresses while DHEAS enhances immune functions.	Dehydroepiandrosterone Sulfate	20-50	sulfotransferase family 2A member 1	Homo sapiens	121-126
17945481-1	2008	The human adrenal reticularis produces the so-called adrenal androgens, dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	106-118	sulfotransferase family 2A member 1	Homo sapiens	120-126
18255343-1	2008	Dehydroepiandrosterone sulfate (DHEAS) is a hormone produced by the adrenal gland and is a precursor for both androgens and estrogens.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
17933750-6	2007	CIMT correlated directly with serum total and free testosterone, androstenedione and dehydroepiandrosterone-sulfate levels and mean 24-h heart rate (HR), and inversely with the insulin sensitivity index (ISI), but no correlation was observed with the body mass index (BMI).	Dehydroepiandrosterone Sulfate	85-115	CIMT	Homo sapiens	0-4
18493139-2	2008	In adulthood, such prenatally androgenized female monkeys exhibit elevated basal circulating levels of dehydroepiandrosterone sulfate (DHEAS), typical of polycystic ovary syndrome (PCOS) women with adrenal androgen excess.	Dehydroepiandrosterone Sulfate	103-133	sulfotransferase family 2A member 1	Homo sapiens	135-140
19177790-1	2008	The aim of this study was to assess external respiratory function in patients with bronchial asthma (BA) and different serum levels of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	156-186	sulfotransferase family 2A member 1	Homo sapiens	188-193
17853076-1	2007	Dehydroepiandrosterone sulphate (DHEAS) has been widely associated with aging, but little is known about age-related decline of DHEAS in non-western populations.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-38
18064919-1	2007	INTRODUCTION: We examined the responsiveness of both cortisol and dehydroepiandrosterone sulfate (DHEAS) to the stress of survival training in military men and evaluated relationships to performance, peritraumatic dissociation, and the subsequent impact of stressful events.	Dehydroepiandrosterone Sulfate	66-96	sulfotransferase family 2A member 1	Homo sapiens	98-103
18441515-2	2008	When expressed in Xenopus oocytes, UST1r mediated uptake of ochratoxin A (OTA; K(m) = 1.0 microM) and sulfate conjugates of steroids, such as estrone-3-sulfate (ES; K(m) = 3.1 microM) and dehydroepiandrosterone sulfate (DHEAS; K(m) = 2.1 microM) in a sodium-independent manner.	Dehydroepiandrosterone Sulfate	188-218	solute carrier family 22, member 25	Rattus norvegicus	35-40
18441515-2	2008	When expressed in Xenopus oocytes, UST1r mediated uptake of ochratoxin A (OTA; K(m) = 1.0 microM) and sulfate conjugates of steroids, such as estrone-3-sulfate (ES; K(m) = 3.1 microM) and dehydroepiandrosterone sulfate (DHEAS; K(m) = 2.1 microM) in a sodium-independent manner.	Dehydroepiandrosterone Sulfate	220-225	solute carrier family 22, member 25	Rattus norvegicus	35-40
18003813-2	2008	The aim of our study was to investigate the use of plasma levels of dehydroepiandrosterone sulfate (DHEAS), albumin, and C-reactive protein (CRP) as alternate prognostic markers for antiretroviral treatment (ART) response in place of HIV-1 load measurements.	Dehydroepiandrosterone Sulfate	68-98	sulfotransferase family 2A member 1	Homo sapiens	100-105
17761949-6	2007	Consistent with these results, increased SF-1 levels selectively modulate the steroid secretion profile of adrenocortical cells, reducing cortisol and aldosterone production and maintaining dehydroepiandrosterone sulfate secretion.	Dehydroepiandrosterone Sulfate	190-220	splicing factor 1	Mus musculus	41-45
17932770-2	2007	Although ovaries are the main source of increased androgens in the syndrome, between 20 and 30% of patients with PCOS have adrenal androgen (AA) excess, detectable primarily by elevated dehydroepiandrosterone sulfate (DHEAS) levels.	Dehydroepiandrosterone Sulfate	186-216	sulfotransferase family 2A member 1	Homo sapiens	218-223
17900832-0	2007	Circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in women suffering from chronic idiopathic urticaria in relation to their pre- or post-menopausal status.	Dehydroepiandrosterone Sulfate	29-59	sulfotransferase family 2A member 1	Homo sapiens	61-67
17998499-1	2007	BACKGROUND: Aging in men is characterized by a progressive decline in levels of anabolic hormones, such as testosterone, insulinlike growth factor 1 (IGF-1), and dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	162-192	sulfotransferase family 2A member 1	Homo sapiens	194-200
17888053-1	2007	AIM: To study the relationship between serum cortisol and dehydroepiandrosterone sulphate (DHEAS) concentrations and death or bronchopulmonary dysplasia at 36 weeks of postmenstrual age in preterm infants.	Dehydroepiandrosterone Sulfate	58-89	sulfotransferase family 2A member 1	Homo sapiens	91-96
18205106-3	2007	It has been postulated that low levels of total testosterone and dehydroepiandrosterone sulfate (DHEA-S) are associated with unfavorable levels of several strong cardiovascular disease risk factors, such as lipids and blood pleasure, which are components of the metabolic syndrome, and insulin levels.	Dehydroepiandrosterone Sulfate	65-95	insulin	Homo sapiens	286-293
18205106-3	2007	It has been postulated that low levels of total testosterone and dehydroepiandrosterone sulfate (DHEA-S) are associated with unfavorable levels of several strong cardiovascular disease risk factors, such as lipids and blood pleasure, which are components of the metabolic syndrome, and insulin levels.	Dehydroepiandrosterone Sulfate	97-103	insulin	Homo sapiens	286-293
18250551-4	2007	Total and free testosterone and dehydroepiandrosterone-sulfate (DHEA-S) were significantly correlated with %FMD (r=0.261, 0.354 and 0.295, respectively; p&lt;0.001), while estradiol and cortisol were not.	Dehydroepiandrosterone Sulfate	32-62	sulfotransferase family 2A member 1	Homo sapiens	64-70
17604264-1	2007	INTRODUCTION: CYP3A7*1C polymorphism has been shown to be associated with lower levels of serum dehydroepiandrosterone sulphate in men.	Dehydroepiandrosterone Sulfate	96-127	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	14-20
17715402-5	2007	Here, we investigate the inhibition of the UNC-49 GABA receptor by another sulfated neurosteroid, dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	98-128	sulfotransferase family 2A member 1	Homo sapiens	130-135
17868658-0	2007	The steroid sulfatase inhibitor COUMATE attenuates rather than enhances access of dehydroepiandrosterone sulfate to the brain in the mouse.	Dehydroepiandrosterone Sulfate	82-112	steroid sulfatase	Mus musculus	4-21
17868658-6	2007	The results suggest that the arylsulfamate based steroid sulfatase inhibitors such as COUMATE interfere with the influx of the DHEAS anion into the brain.	Dehydroepiandrosterone Sulfate	127-132	steroid sulfatase	Mus musculus	49-66
17548088-0	2007	In vitro effect of dehydroepiandrosterone sulfate on steroid receptors, aromatase, cyclooxygenase-2 expression, and steroid hormone production in preovulatory human granulosa cells.	Dehydroepiandrosterone Sulfate	19-49	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-99
17640817-1	2007	Dehydroepiandrosterone sulfate (DHEAS) has been shown to enhance memory retention in different animal models and in various learning paradigms.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
17827029-0	2007	Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria.	Dehydroepiandrosterone Sulfate	101-131	interleukin 6	Homo sapiens	24-37
17827029-0	2007	Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria.	Dehydroepiandrosterone Sulfate	101-131	interleukin 6	Homo sapiens	39-43
17827029-0	2007	Plasma concentration of interleukin 6 (IL-6), and its relationship with circulating concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with chronic idiopathic urticaria.	Dehydroepiandrosterone Sulfate	101-131	sulfotransferase family 2A member 1	Homo sapiens	133-139
17519314-8	2007	In healthy children, SHBG was significantly negatively correlated with testosterone, estradiol, dehydroepiandrosterone sulfate, and body mass index (BMI) in boys (total model R(2) = 0.71) but only with dehydroepiandrosterone sulfate and BMI in girls (total model R(2) = 0.26).	Dehydroepiandrosterone Sulfate	96-126	sex hormone binding globulin	Homo sapiens	21-25
17519314-8	2007	In healthy children, SHBG was significantly negatively correlated with testosterone, estradiol, dehydroepiandrosterone sulfate, and body mass index (BMI) in boys (total model R(2) = 0.71) but only with dehydroepiandrosterone sulfate and BMI in girls (total model R(2) = 0.26).	Dehydroepiandrosterone Sulfate	202-232	sex hormone binding globulin	Homo sapiens	21-25
17905395-1	2007	Adrenal function and aging have been the object of intense interest recently, especially as regards dehydroepiandrosterone sulfate (DHEA-S), which is of major importance, since it is distinct from cortisol and aldosterone in declining with age.	Dehydroepiandrosterone Sulfate	100-130	sulfotransferase family 2A member 1	Homo sapiens	132-138
17653066-9	2007	Mean dehydroepiandrosterone sulfate (DHEAS) levels were elevated in boys (within age ranges 8-10 years and 12-16 years, P&lt;0.02) and in girls (within age ranges 6-8 years and 12-18 years, P&lt;0.005) and mean testosterone levels in boys &gt;12 years were lower as compared to reference ranges (all P-values &lt;0.0001).	Dehydroepiandrosterone Sulfate	5-35	sulfotransferase family 2A member 1	Homo sapiens	37-42
17662597-10	2007	High expression levels of steroid sulfotransferase SULT2B1B and type 3 3alpha-HSD (AKR1C2) correspond to the high levels of DHEA sulfate (DHEAS) and ADT formed from DHEA and 4-dione, respectively.	Dehydroepiandrosterone Sulfate	124-136	aldo-keto reductase family 1 member C4	Homo sapiens	71-81
17662597-10	2007	High expression levels of steroid sulfotransferase SULT2B1B and type 3 3alpha-HSD (AKR1C2) correspond to the high levels of DHEA sulfate (DHEAS) and ADT formed from DHEA and 4-dione, respectively.	Dehydroepiandrosterone Sulfate	124-136	aldo-keto reductase family 1 member C2	Homo sapiens	83-89
17662597-10	2007	High expression levels of steroid sulfotransferase SULT2B1B and type 3 3alpha-HSD (AKR1C2) correspond to the high levels of DHEA sulfate (DHEAS) and ADT formed from DHEA and 4-dione, respectively.	Dehydroepiandrosterone Sulfate	138-143	aldo-keto reductase family 1 member C4	Homo sapiens	71-81
17662597-10	2007	High expression levels of steroid sulfotransferase SULT2B1B and type 3 3alpha-HSD (AKR1C2) correspond to the high levels of DHEA sulfate (DHEAS) and ADT formed from DHEA and 4-dione, respectively.	Dehydroepiandrosterone Sulfate	138-143	aldo-keto reductase family 1 member C2	Homo sapiens	83-89
17884105-5	2007	rOscp1 also transported various structurally heterogenous compounds such as testosterone, dehydroepiandrosterone sulfate (DHEA-S), and taurocholate with some differences in substrate specificity compared with hOSCP1.	Dehydroepiandrosterone Sulfate	90-120	organic solute carrier partner 1	Rattus norvegicus	0-6
17884105-5	2007	rOscp1 also transported various structurally heterogenous compounds such as testosterone, dehydroepiandrosterone sulfate (DHEA-S), and taurocholate with some differences in substrate specificity compared with hOSCP1.	Dehydroepiandrosterone Sulfate	122-128	organic solute carrier partner 1	Rattus norvegicus	0-6
17727347-11	2007	All agree that dehydroepiandrosterone sulfate (DHEA-S) production from the adrenal gland begins during the preteen years, peaks in the mid 20s, then declines progressively over time.	Dehydroepiandrosterone Sulfate	15-45	sulfotransferase family 2A member 1	Homo sapiens	47-53
17604264-3	2007	We hypothesized that CYP3A7*1C may lead to bone loss through decreased levels of dehydroepiandrosterone sulphate in postmenopausal women.	Dehydroepiandrosterone Sulfate	81-112	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	21-27
17491011-7	2007	We established a stable SOAT-HEK293 cell line that showed sodium-dependent transport of dehydroepiandrosterone sulfate, estrone-3-sulfate, and pregnenolone sulfate with apparent K(m) values of 28.7, 12.0, and 11.3 microm, respectively.	Dehydroepiandrosterone Sulfate	88-118	solute carrier family 10 member 6	Homo sapiens	24-28
17446263-5	2007	mOscp1 transported various kinds of structurally dissimilar drugs and chemicals such as probenecid, dehydroepiandrosterone sulfate, and glutarate with some differences in substrate specificity compared with hOSCP1.	Dehydroepiandrosterone Sulfate	100-130	organic solute carrier partner 1	Mus musculus	0-6
17426092-1	2007	CONTEXT: The adrenal androgen (AA) metabolite dehydroepiandrosterone sulfate (DHEAS) is often elevated in women with polycystic ovary syndrome (PCOS); AA excess in PCOS appears to be, in part, a heritable trait.	Dehydroepiandrosterone Sulfate	46-76	sulfotransferase family 2A member 1	Homo sapiens	78-83
17456573-5	2007	Additionally, we studied the effects of testosterone, 17beta-estradiol, androstenedione, and dehydroepiandrosterone sulfate on RBP4 expression in adipose tissue explants.	Dehydroepiandrosterone Sulfate	93-123	retinol binding protein 4	Homo sapiens	127-131
17802803-3	2007	The latter increased significantly in Group 1 and insignificantly in Group 2 and did not differ from the normal values in Group 3, at the same time the concentration of E-2 elevated in Groups 1 and 2, rather than in Group 3; the level of DEAS-S increased in Groups 2 and 3 irrespective of the duration of use.	Dehydroepiandrosterone Sulfate	238-244	cystatin 12, pseudogene	Homo sapiens	169-172
17187946-7	2007	RESULTS: A polymorphism in CYP1B1 was associated with lower dehydroepiandrosterone-sulfate (DHEA-S) and progesterone levels, while a polymorphism in CYP19 (aromatase) was associated with higher testosterone and DHEA-S levels.	Dehydroepiandrosterone Sulfate	60-90	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	27-33
17187946-7	2007	RESULTS: A polymorphism in CYP1B1 was associated with lower dehydroepiandrosterone-sulfate (DHEA-S) and progesterone levels, while a polymorphism in CYP19 (aromatase) was associated with higher testosterone and DHEA-S levels.	Dehydroepiandrosterone Sulfate	60-90	sulfotransferase family 2A member 1	Homo sapiens	92-98
17894007-8	2007	It has been shown that patients with Sjogren"s syndrome have low concentrations of circulating dehydroepiandrosterone sulfate (DHEA-S) compared to age-matched healthy controls.	Dehydroepiandrosterone Sulfate	95-125	sulfotransferase family 2A member 1	Homo sapiens	127-133
17381481-0	2007	Independent association between insulin-like growth factor-I and dehydroepiandrosterone sulphate in women in middle adulthood.	Dehydroepiandrosterone Sulfate	65-96	insulin like growth factor 1	Homo sapiens	32-60
17381481-1	2007	OBJECTIVE: The age-related decrease in circulating dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor (IGF)-I levels is suggested to be involved in various age-related changes.	Dehydroepiandrosterone Sulfate	51-82	sulfotransferase family 2A member 1	Homo sapiens	84-89
17631763-17	2007	In PL, the levels of CRH and cortisol and dehydroepiandrosterone sulfate in umbilical cord blood were correlated respectively with each other (r=0.523 and 0.424, P&lt;0.05), and in TL the level of CRH was correlated with cortisol and dehydroepiandrosterone sulfate respectively (r=0.438 and 0.354, P&lt;0.05).	Dehydroepiandrosterone Sulfate	234-264	corticotropin releasing hormone	Homo sapiens	21-24
17594810-0	2007	[Molecular mechanisms of DHEA and DHEAs on apoptosis and cell cycle arrest via Akt pathway in hepatoma cell lines].	Dehydroepiandrosterone Sulfate	34-39	AKT serine/threonine kinase 1	Homo sapiens	79-82
17309739-0	2007	Serum prolactin concentration and its relationship with dehydroepiandrosterone sulfate concentration in chronic urticaria patients with positive and negative response to autologous serum skin test.	Dehydroepiandrosterone Sulfate	56-86	prolactin	Homo sapiens	6-15
17495190-2	2007	In this study, we analyzed the relationship of dehydroepiandrosterone sulfate (DHEA-S) with the alterations associated with overweight by analyzing the influence of this hormone in the differences found in biochemical variables between normal-weight and overweight prepubertal children.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-85
17452968-4	2007	If the fetus lacks aromatase activity, dehydroepiandrosterone sulfate produced by the fetal adrenal glands cannot be converted to estrogen by the placenta, so is converted to testosterone peripherally and results in virilization of both fetus and mother.	Dehydroepiandrosterone Sulfate	39-69	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	19-28
17082909-0	2007	Dehydroepiandrosterone sulphate enhances IgG and Interferon-gamma production during immunization to tuberculosis in young but not aged mice.	Dehydroepiandrosterone Sulfate	0-31	immunoglobulin heavy variable V1-62	Mus musculus	41-44
17082909-0	2007	Dehydroepiandrosterone sulphate enhances IgG and Interferon-gamma production during immunization to tuberculosis in young but not aged mice.	Dehydroepiandrosterone Sulfate	0-31	interferon gamma	Mus musculus	49-65
17082909-5	2007	Young mice co-immunized with mycHSP70-DHEAS presented an early increase in specific IgG levels and showed increased Interferon-gamma production compared to old mice.	Dehydroepiandrosterone Sulfate	38-43	immunoglobulin heavy variable V1-62	Mus musculus	84-87
17082909-5	2007	Young mice co-immunized with mycHSP70-DHEAS presented an early increase in specific IgG levels and showed increased Interferon-gamma production compared to old mice.	Dehydroepiandrosterone Sulfate	38-43	interferon gamma	Mus musculus	116-132
17284620-3	2007	OBJECTIVE: Our objective was to determine whether endogenous androgen and dehydroepiandrosterone sulfate (DHEAS) levels: 1) are reduced in women with anorexia nervosa and normal-weight hypothalamic amenorrhea, 2) are reduced further by oral contraceptives in women with anorexia nervosa, and 3) are predictors of weight, body composition, or bone density in such women.	Dehydroepiandrosterone Sulfate	74-104	sulfotransferase family 2A member 1	Homo sapiens	106-111
17470679-3	2007	STS hydrolyzes steroid sulfates, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS), to estrone and DHEA, which can be converted to steroids with potent estrogenic properties, that is, estradiol and androstenediol, respectively.	Dehydroepiandrosterone Sulfate	61-91	sulfotransferase family 2A member 1	Homo sapiens	93-98
16963172-1	2007	Dehydroepiandrosterone sulfate (DHEAS) is an excitatory neurosteroid with anti-glucocorticoid properties.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
17334880-1	2007	The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	63-93	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	4-10
17334880-1	2007	The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	63-93	sulfotransferase family 2A member 1	Homo sapiens	95-100
17178770-2	2007	Although CYP3A7 shares nearly 90% base sequence with CYP3A4, CYP3A7 shows striking functional differences in the catalytic preference for several substrates, such as dehydroepiandrosterone (DHEA) or dehydroepiandrosterone 3-sulfate (DHEA-3S).	Dehydroepiandrosterone Sulfate	199-231	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	9-15
17178770-2	2007	Although CYP3A7 shares nearly 90% base sequence with CYP3A4, CYP3A7 shows striking functional differences in the catalytic preference for several substrates, such as dehydroepiandrosterone (DHEA) or dehydroepiandrosterone 3-sulfate (DHEA-3S).	Dehydroepiandrosterone Sulfate	199-231	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	53-59
17178770-2	2007	Although CYP3A7 shares nearly 90% base sequence with CYP3A4, CYP3A7 shows striking functional differences in the catalytic preference for several substrates, such as dehydroepiandrosterone (DHEA) or dehydroepiandrosterone 3-sulfate (DHEA-3S).	Dehydroepiandrosterone Sulfate	199-231	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	61-67
17141281-0	2007	Neurosteroid dehydroepiandrosterone sulfate enhances spontaneous glutamate release in rat prelimbic cortex through activation of dopamine D1 and sigma-1 receptor.	Dehydroepiandrosterone Sulfate	13-43	sigma non-opioid intracellular receptor 1	Rattus norvegicus	129-161
16912139-2	2006	OBJECTIVE: The objective of the study was to investigate racial/ethnic variations in testosterone, bioavailable testosterone, dihydrotestosterone (DHT), SHBG, and dehydroepiandrosterone sulfate (DHEAS) levels.	Dehydroepiandrosterone Sulfate	163-193	sulfotransferase family 2A member 1	Homo sapiens	195-200
18229649-1	2007	PURPOSE: The aim of the study was evaluation of dehydroepiandrosterone sulphate (DHEA-S) serum concentration in elderly women and determining interdependence between DHEA-S levels and occurrence of diseases typical for this period of life.	Dehydroepiandrosterone Sulfate	48-79	sulfotransferase family 2A member 1	Homo sapiens	81-87
17690503-0	2007	Relation of serum levels of estrogen and dehydroepiandrosterone sulfate to hormone receptor status among postmenopausal women with breast cancer.	Dehydroepiandrosterone Sulfate	41-71	nuclear receptor subfamily 4 group A member 1	Homo sapiens	75-91
17038555-5	2007	TNF-alpha treatment (1 nM for 48 h) decreased the basal production of cortisol, androstenedione, dehydroepiandrosterone sulfate (DHEAS), and aldosterone (14, 18, 35, and 52%, respectively), and the 8-bromo-cAMP-induced production of cortisol, androstenedione, dehydroepiandrosterone (DHEA), and DHEAS (44, 66, 58, and 48%, respectively).	Dehydroepiandrosterone Sulfate	97-127	tumor necrosis factor	Homo sapiens	0-9
17038555-5	2007	TNF-alpha treatment (1 nM for 48 h) decreased the basal production of cortisol, androstenedione, dehydroepiandrosterone sulfate (DHEAS), and aldosterone (14, 18, 35, and 52%, respectively), and the 8-bromo-cAMP-induced production of cortisol, androstenedione, dehydroepiandrosterone (DHEA), and DHEAS (44, 66, 58, and 48%, respectively).	Dehydroepiandrosterone Sulfate	97-127	sulfotransferase family 2A member 1	Homo sapiens	129-134
17583102-2	2007	OBJECTIVE: We evaluated serum concentration of dehydroepiandrosterone sulfate (DHEA-S) and total testosterone in women with severe AEDS to characterize the hormonal milieu of such patients.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-85
17497462-0	2007	Low plasma dehydroepiandrosterone sulfate level and its relationship to adiponectin in hemodialysis patients.	Dehydroepiandrosterone Sulfate	11-41	adiponectin, C1Q and collagen domain containing	Homo sapiens	72-83
17109709-1	2006	Although numerous studies have identified a correlation between dehydroepiandrosterone sulfate (DHEAS) levels and anxiety or depression, those findings remain controversial.	Dehydroepiandrosterone Sulfate	64-94	sulfotransferase family 2A member 1	Homo sapiens	96-101
16990659-0	2006	Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans.	Dehydroepiandrosterone Sulfate	10-22	adiponectin, C1Q and collagen domain containing	Homo sapiens	26-37
16990659-1	2006	OBJECTIVE: A growing body of studies has demonstrated the inverse relationship between DHEA-sulfate (DHEA-S) and the pathological alterations associated with the metabolic syndrome.	Dehydroepiandrosterone Sulfate	87-99	sulfotransferase family 2A member 1	Homo sapiens	101-107
16978135-3	2006	The present study investigated the effect of a 25-day mountaineering activity on glucose tolerance and its relation to serum levels of dehydroepiandrosterone-sulfate (DHEA-S) and tumor necrosis factor-alpha (TNF-alpha) in 12 male subjects.	Dehydroepiandrosterone Sulfate	135-165	sulfotransferase family 2A member 1	Homo sapiens	167-173
16835279-3	2006	Circulating total estradiol (and calculated free levels), FSH, and dehydroepiandrosterone sulfate (DHEAS) were measured between September 1994 and September 1995 and provided a unique opportunity to study effects of extreme seasonal variations in the daylight on hormone levels in an arctic population.	Dehydroepiandrosterone Sulfate	67-97	sulfotransferase family 2A member 1	Homo sapiens	99-104
16895729-0	2006	Dehydroepiandrosterone sulfate prevents ischemia-induced impairment of long-term potentiation in rat hippocampal CA1 by up-regulating tyrosine phosphorylation of NMDA receptor.	Dehydroepiandrosterone Sulfate	0-30	carbonic anhydrase 1	Rattus norvegicus	113-116
16895729-1	2006	We have reported that dehydroepiandrosterone sulfate (DHEAS) reduces the threshold for long-term potentiation (LTP) in Shaffer collateral-CA1 synapses through the amplification of Src-dependent NMDA receptor signaling.	Dehydroepiandrosterone Sulfate	22-52	carbonic anhydrase 1	Rattus norvegicus	138-141
16895729-1	2006	We have reported that dehydroepiandrosterone sulfate (DHEAS) reduces the threshold for long-term potentiation (LTP) in Shaffer collateral-CA1 synapses through the amplification of Src-dependent NMDA receptor signaling.	Dehydroepiandrosterone Sulfate	54-59	carbonic anhydrase 1	Rattus norvegicus	138-141
16895729-5	2006	Co-administration of the specific sigma(1) receptor antagonist NE100 with DHEAS completely prevented the protective effect of DHEAS.	Dehydroepiandrosterone Sulfate	74-79	sigma non-opioid intracellular receptor 1	Rattus norvegicus	34-51
16895729-5	2006	Co-administration of the specific sigma(1) receptor antagonist NE100 with DHEAS completely prevented the protective effect of DHEAS.	Dehydroepiandrosterone Sulfate	126-131	sigma non-opioid intracellular receptor 1	Rattus norvegicus	34-51
16895729-8	2006	Furthermore, the repetitive administration of DHEAS improved the reduction in tyrosine phosphorylation of NR2B.	Dehydroepiandrosterone Sulfate	46-51	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	106-110
16895729-9	2006	These findings suggest that the repetitive activation of sigma(1) receptor induced by DHEAS might prevent the ischemic LTP impairment through regulating the tyrosine phosphorylation of NR2B.	Dehydroepiandrosterone Sulfate	86-91	sigma non-opioid intracellular receptor 1	Rattus norvegicus	57-74
16895729-9	2006	These findings suggest that the repetitive activation of sigma(1) receptor induced by DHEAS might prevent the ischemic LTP impairment through regulating the tyrosine phosphorylation of NR2B.	Dehydroepiandrosterone Sulfate	86-91	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	185-189
17429562-1	2007	BACKGROUND: We postulate that the androgen dehydroepiandrosterone sulfate (DHEAS) may represent an innovative hormonal treatment for estrogen (ER), progesterone (PR) receptor-negative, but androgen receptor (AR)-positive breast cancers by inhibiting breast cancer cell growth through AR stimulation.	Dehydroepiandrosterone Sulfate	43-73	sulfotransferase family 2A member 1	Homo sapiens	75-80
17429562-1	2007	BACKGROUND: We postulate that the androgen dehydroepiandrosterone sulfate (DHEAS) may represent an innovative hormonal treatment for estrogen (ER), progesterone (PR) receptor-negative, but androgen receptor (AR)-positive breast cancers by inhibiting breast cancer cell growth through AR stimulation.	Dehydroepiandrosterone Sulfate	43-73	androgen receptor	Homo sapiens	189-206
17157799-1	2007	PURPOSE: To evaluate plasma dehydroepiandrosterone sulphate (DHEAS) levels in patients diagnosed with age-related macular degeneration (AMD) and controls.	Dehydroepiandrosterone Sulfate	28-59	sulfotransferase family 2A member 1	Homo sapiens	61-66
17077135-2	2007	HYPOTHESIS: Placental factors up-regulate dehydroepiandrosterone sulfate (DHEA-S) generation.	Dehydroepiandrosterone Sulfate	42-72	sulfotransferase family 2A member 1	Homo sapiens	74-80
18154121-2	2007	That was demonstrated for apolipoprotein A-1 complexes with dehydroepiandrosterone, dehydroepiandrosterone sulfate and tetrahydrocortisol.	Dehydroepiandrosterone Sulfate	84-114	apolipoprotein A-I	Mus musculus	26-44
17308139-10	2006	However, hyperandrogenic patients with increased dehydroepiandrosterone sulfate (DHEAS) tend to have lower body weight and insulin levels and a better metabolic profile.	Dehydroepiandrosterone Sulfate	49-79	insulin	Homo sapiens	123-130
17308139-10	2006	However, hyperandrogenic patients with increased dehydroepiandrosterone sulfate (DHEAS) tend to have lower body weight and insulin levels and a better metabolic profile.	Dehydroepiandrosterone Sulfate	81-86	insulin	Homo sapiens	123-130
17132759-1	2006	OBJECTIVE: To investigate whether circulating levels of testosterone (total, bioavailable), estradiol (total, bioavailable), and DHEA sulfate (DHEAS) are associated with fasting plasma homocysteine (tHcy) levels in middle-aged and elderly men.	Dehydroepiandrosterone Sulfate	129-141	sulfotransferase family 2A member 1	Homo sapiens	143-148
17157776-1	2006	UNLABELLED: Dehydroepandrosterone (DHEA)-dehydroepiandrosterone sulfate (DHEAS) deficiency often produces fatigue, depression, weakness, and sexual dysfunction, which improve during replacement therapy.	Dehydroepiandrosterone Sulfate	41-71	sulfotransferase family 2A member 1	Homo sapiens	73-78
16889589-1	2006	OBJECTIVE: Increased plasma dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS) have been demonstrated in post-traumatic stress disorder (PTSD), but the documented beneficial effects of these steroids in enhancing mood and cognition, as well as neuroprotection, suggest their presence in PTSD may be associated with defensive rather than maladaptive effects.	Dehydroepiandrosterone Sulfate	62-92	sulfotransferase family 2A member 1	Homo sapiens	94-99
17091201-4	2006	Salivary dehydroepiandrosterone-sulfate (DHEAS), a cortisol counterbalancing product of the HPA axis, was measured on these days 1 hour after managers awakened.	Dehydroepiandrosterone Sulfate	9-39	sulfotransferase family 2A member 1	Homo sapiens	41-46
17003845-1	2006	The purpose of this study was to determine the association between the level of salivary dehydroepiandrosterone sulfate (DHEA-S) and the magnitude of adaptation to exercise training in insulin sensitivity for aged females.	Dehydroepiandrosterone Sulfate	89-119	sulfotransferase family 2A member 1	Homo sapiens	121-127
16917887-1	2006	Adrenarche, the prepubertal onset of adrenal production of dehydroepiandrosterone sulfate (DHEAS), is a distinctive aspect of the human life course.	Dehydroepiandrosterone Sulfate	59-89	sulfotransferase family 2A member 1	Homo sapiens	91-96
17071537-9	2006	Also, their level of sex hormone-binding globulin was significantly lower and hence their free androgen index was higher, and so was their level of dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	148-178	sex hormone binding globulin	Homo sapiens	21-49
16979704-1	2006	OBJECTIVES: To investigate the effect of sildenafil citrate treatment on serum dehydroepiandrosterone sulfate (DHEAS) levels in patients with erectile dysfunction (ED).	Dehydroepiandrosterone Sulfate	79-109	sulfotransferase family 2A member 1	Homo sapiens	111-116
16960027-1	2006	BACKGROUND: Dehydroepiandrosterone sulfate (DHEAS) is an endogenously produced sex steroid that has been hypothesized to have anti-aging effects.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-49
16966120-1	2006	OBJECTIVE: To examine if changes in fetal plasma concentrations of cortisol or dehydroepiandrosterone sulfate (DHEAS) levels are associated with human term parturition.	Dehydroepiandrosterone Sulfate	79-109	sulfotransferase family 2A member 1	Homo sapiens	111-116
16754786-10	2006	Compared with OATP2B1, C493A and C557A transported estrone-3-sulfate and dehydroepiandrosterone sulfate less efficiently, whereas all other mutants were functionally impaired.	Dehydroepiandrosterone Sulfate	73-103	solute carrier organic anion transporter family member 2B1	Homo sapiens	14-21
16806295-0	2006	Chronic DHEAS administration facilitates hippocampal long-term potentiation via an amplification of Src-dependent NMDA receptor signaling.	Dehydroepiandrosterone Sulfate	8-13	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	100-103
16806295-2	2006	Recently we have reported that repetitive administration of DHEAS lowers the threshold pulse number in inducing activity-dependent long-term potentiation (LTP) in rat hippocampal Schaffer collateral-CA1 synapses, in which a sub-threshold high frequency stimulation (HFS, 30 pulses at 100 Hz) for normal rats could induce robust LTP in DHEAS-treated rats (Chen et al., 2006).	Dehydroepiandrosterone Sulfate	60-65	carbonic anhydrase 1	Rattus norvegicus	199-202
16806295-3	2006	Here we report that the sub-threshold HFS could trigger the phosphorylation of Src and ERK2 in the DHEAS-treated rats, but not in control rats.	Dehydroepiandrosterone Sulfate	99-104	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	79-82
16806295-3	2006	Here we report that the sub-threshold HFS could trigger the phosphorylation of Src and ERK2 in the DHEAS-treated rats, but not in control rats.	Dehydroepiandrosterone Sulfate	99-104	mitogen activated protein kinase 1	Rattus norvegicus	87-91
16806295-4	2006	We found in slices obtained from the DHEAS-treated rats that NMDA-induced intracellular Ca2+([Ca2+]i) transients in CA1 pyramidal neurons were significantly potentiated, which was essential for the Src and ERK2 phosphorylations.	Dehydroepiandrosterone Sulfate	37-42	carbonic anhydrase 2	Rattus norvegicus	88-91
16806295-4	2006	We found in slices obtained from the DHEAS-treated rats that NMDA-induced intracellular Ca2+([Ca2+]i) transients in CA1 pyramidal neurons were significantly potentiated, which was essential for the Src and ERK2 phosphorylations.	Dehydroepiandrosterone Sulfate	37-42	carbonic anhydrase 2	Rattus norvegicus	94-97
16806295-4	2006	We found in slices obtained from the DHEAS-treated rats that NMDA-induced intracellular Ca2+([Ca2+]i) transients in CA1 pyramidal neurons were significantly potentiated, which was essential for the Src and ERK2 phosphorylations.	Dehydroepiandrosterone Sulfate	37-42	carbonic anhydrase 1	Rattus norvegicus	116-119
16806295-4	2006	We found in slices obtained from the DHEAS-treated rats that NMDA-induced intracellular Ca2+([Ca2+]i) transients in CA1 pyramidal neurons were significantly potentiated, which was essential for the Src and ERK2 phosphorylations.	Dehydroepiandrosterone Sulfate	37-42	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	198-201
16806295-4	2006	We found in slices obtained from the DHEAS-treated rats that NMDA-induced intracellular Ca2+([Ca2+]i) transients in CA1 pyramidal neurons were significantly potentiated, which was essential for the Src and ERK2 phosphorylations.	Dehydroepiandrosterone Sulfate	37-42	mitogen activated protein kinase 1	Rattus norvegicus	206-210
16806295-5	2006	The activation of ERK2, a downstream factor of Src family kinase, was required for the DHEAS-facilitated LTP.	Dehydroepiandrosterone Sulfate	87-92	mitogen activated protein kinase 1	Rattus norvegicus	18-22
16806295-5	2006	The activation of ERK2, a downstream factor of Src family kinase, was required for the DHEAS-facilitated LTP.	Dehydroepiandrosterone Sulfate	87-92	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	47-50
16806295-6	2006	The Src family kinase inhibitor PP2, but not its inactive homologue PP3, attenuated the NMDA-induced [Ca2+]i increase and abolished the DHEAS-facilitated LTP.	Dehydroepiandrosterone Sulfate	136-141	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	4-7
16806295-7	2006	These findings suggest that the chronic administration of DHEAS brings the NMDA receptor (NMDAr) to a potentiated state that causes an enough level of [Ca2+]i increase for LTP induction even by the sub-threshold HFS.	Dehydroepiandrosterone Sulfate	58-63	carbonic anhydrase 2	Rattus norvegicus	152-155
16806295-9	2006	This novel postsynaptic NMDAr/Src-mediated signal amplification through "NMDAr-Ca2+--&gt;Src--&gt;NMDAr-Ca2+" cycle may play a pivotal role in the DHEAS-facilitated LTP induction.	Dehydroepiandrosterone Sulfate	147-152	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	30-33
16806295-9	2006	This novel postsynaptic NMDAr/Src-mediated signal amplification through "NMDAr-Ca2+--&gt;Src--&gt;NMDAr-Ca2+" cycle may play a pivotal role in the DHEAS-facilitated LTP induction.	Dehydroepiandrosterone Sulfate	147-152	carbonic anhydrase 2	Rattus norvegicus	79-82
16806295-9	2006	This novel postsynaptic NMDAr/Src-mediated signal amplification through "NMDAr-Ca2+--&gt;Src--&gt;NMDAr-Ca2+" cycle may play a pivotal role in the DHEAS-facilitated LTP induction.	Dehydroepiandrosterone Sulfate	147-152	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	89-92
16806295-9	2006	This novel postsynaptic NMDAr/Src-mediated signal amplification through "NMDAr-Ca2+--&gt;Src--&gt;NMDAr-Ca2+" cycle may play a pivotal role in the DHEAS-facilitated LTP induction.	Dehydroepiandrosterone Sulfate	147-152	carbonic anhydrase 2	Rattus norvegicus	104-107
16908055-1	2006	It has been hypothesized that increased baseline dehydroepiandrosterone sulfate (DHEAS) levels may act as a natural antidepressant to attenuate negative affect during cocaine withdrawal and abstinence, decreasing the probability of relapse.	Dehydroepiandrosterone Sulfate	49-79	sulfotransferase family 2A member 1	Homo sapiens	81-86
16937748-4	2006	Dehydroepiandrosterone sulfate (DHEA-S) is a corticotropin-dependent adrenal androgen precursor that is suppressible in patients treated with ICs.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-38
16716364-0	2006	Effect of resistance exercise on dehydroepiandrosterone sulfate concentrations during a 72-h recovery: relation to glucose tolerance and insulin response.	Dehydroepiandrosterone Sulfate	33-63	insulin	Homo sapiens	137-144
16716364-1	2006	Serum dehydroepiandrosterone sulfate (DHEA-S) concentration is known to be associated with the whole-body insulin sensitivity.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-44
16716364-1	2006	Serum dehydroepiandrosterone sulfate (DHEA-S) concentration is known to be associated with the whole-body insulin sensitivity.	Dehydroepiandrosterone Sulfate	6-36	insulin	Homo sapiens	106-113
16880459-1	2006	BACKGROUND: Data suggest that endogenous sex hormones (testosterone, dehydroepiandrosterone sulfate [DHEA-S], and estradiol) influence cardiovascular disease (CVD) risk factors and vascular function.	Dehydroepiandrosterone Sulfate	69-99	sulfotransferase family 2A member 1	Homo sapiens	101-107
16413943-1	2006	We recently found that serum dehydroepiandrosterone sulfate (DHEA-S) concentration correlated inversely with the degree of urinary albumin excretion in a cross-sectional study.	Dehydroepiandrosterone Sulfate	29-59	sulfotransferase family 2A member 1	Homo sapiens	61-67
16788901-7	2006	Placental CRH stimulates the fetal adrenal zone, an adrenal structure unique to primates, to produce dehydroepiandrosterone sulfate (DHEAS), which is converted to estrogen by the placenta.	Dehydroepiandrosterone Sulfate	101-131	corticotropin releasing hormone	Homo sapiens	10-13
16788901-7	2006	Placental CRH stimulates the fetal adrenal zone, an adrenal structure unique to primates, to produce dehydroepiandrosterone sulfate (DHEAS), which is converted to estrogen by the placenta.	Dehydroepiandrosterone Sulfate	133-138	corticotropin releasing hormone	Homo sapiens	10-13
16443373-0	2006	Dehydroepiandrosterone sulfate (DHEAS) and risk for mortality among older Taiwanese.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
16443373-1	2006	PURPOSE: Studies based on Western populations showed a negative relationship between dehydroepiandrosterone sulfate (DHEAS) level and mortality, but no study examined this relationship in a non-Western country.	Dehydroepiandrosterone Sulfate	85-115	sulfotransferase family 2A member 1	Homo sapiens	117-122
16538534-6	2006	A positive correlation was observed between DHEA-S and E1-S (p=0.001) or E2 (p&lt;0.001), while SHBG correlated negatively with E1-S (p=0.024) and E2 (p=0.01), and positively with DHEA-S (p=0.016) and CTX (p=0.040).	Dehydroepiandrosterone Sulfate	180-186	sex hormone binding globulin	Homo sapiens	96-100
16793964-11	2006	Adiponectin was positively correlated with sex hormone-binding globulin (SHBG) (r = 0.39, P &lt; 0.001) and inversely correlated with free-androgen index (r = -0.24, P &lt; 0.01), estradiol and dehydroepiandrosterone sulfate (r = -0.165, P &lt; 0.05; r = -0.21, P &lt; 0.01 respectively).	Dehydroepiandrosterone Sulfate	194-224	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
16609903-2	2006	Several studies have linked plasma levels of cortisol and dehydroepiandrosterone (DHEA) or DHEA-sulfate (DHEAS) to depressive symptoms.	Dehydroepiandrosterone Sulfate	91-103	sulfotransferase family 2A member 1	Homo sapiens	105-110
16608898-1	2006	CONTEXT: Dehydroepiandrosterone (DHEA) replacement in sepsis has been advocated because of the sepsis-associated decrease in serum DHEA sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	131-143	sulfotransferase family 2A member 1	Homo sapiens	145-150
16837617-0	2006	Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue.	Dehydroepiandrosterone Sulfate	91-121	steroid sulfatase	Homo sapiens	59-76
16837617-2	2006	Instead, our data support an intracrine role of adipose tissue, in which adrenal dehydroepiandrosterone sulfate (DHEA-S), the most abundant circulating androgen in man, is selectively uptaken, desulfated, and converted into bioactive androgens and estrogens.	Dehydroepiandrosterone Sulfate	81-111	sulfotransferase family 2A member 1	Homo sapiens	113-119
16772150-2	2006	Specific diagnostic serum markers such as testosterone (total) and dehydroepiandrosterone sulfate (DHEAS), respectively, may be helpful in the diagnosis of ovarian and adrenal hyperandrogenism, respectively.	Dehydroepiandrosterone Sulfate	67-97	sulfotransferase family 2A member 1	Homo sapiens	99-104
16785159-9	2006	When PCOS subjects with the Pro allele and the Ala allele of PPAR-gamma were compared, the latter had lower free testosterone, androstenedione, dehydroepiandrosterone sulfate, insulin and C-peptide levels, as well as lower luteinizing hormone/follicle-stimulating hormone ratio, HOMA insulin resistance index, AUCinsulin, Ferriman-Gallwey score, acne, body mass index and waist-to-hip ratio.	Dehydroepiandrosterone Sulfate	144-174	peroxisome proliferator activated receptor gamma	Homo sapiens	61-71
16704753-11	2006	In 42 female patients with varying degrees of interference, identified on routine assay, regression analysis showed strong association between dehydroepiandrosterone sulphate (DHEA-S) and interference (direct-minus-extracted testosterone) (r = 0.77, P &lt; 0.001).	Dehydroepiandrosterone Sulfate	143-174	sulfotransferase family 2A member 1	Homo sapiens	176-182
16704754-3	2006	We have evaluated the potential for dehydroepiandrosterone sulphate (DHEA-S) to cross-react in the Abbott Architect testosterone assay.	Dehydroepiandrosterone Sulfate	36-67	sulfotransferase family 2A member 1	Homo sapiens	69-75
16702378-6	2006	However, both DHEA and DHEAS were positively associated with estrogen receptor-positive/progesterone receptor-positive breast cancer (DHEA RR, 1.6; 95% CI, 0.9-2.8, P(trend) = 0.09; DHEAS RR, 1.9; 95% CI, 1.1-3.3, P(trend) = 0.02).	Dehydroepiandrosterone Sulfate	23-28	estrogen receptor 1	Homo sapiens	61-78
16257192-5	2006	The substrate specificity of hOAT4 includes various steroid sulfates, such as beta-estradiol-3,17-disulfate, 17-beta-estradiol-3-sulfate, beta-estradiol-3-sulfate, and dehydroepiandrosterone-3-sulfate (DHEAS), but does not include p-aminohippuric acid (PAH) and tetraethylammonium (TEA).	Dehydroepiandrosterone Sulfate	168-200	solute carrier family 22 member 11	Homo sapiens	29-34
16256973-0	2006	Dehydroepiandrosterone sulfate (DHEA-S) distribution in Spanish prepuberal children: relationship with fasting plasma insulin concentrations and insulin resistance.	Dehydroepiandrosterone Sulfate	0-30	insulin	Homo sapiens	118-125
16256973-0	2006	Dehydroepiandrosterone sulfate (DHEA-S) distribution in Spanish prepuberal children: relationship with fasting plasma insulin concentrations and insulin resistance.	Dehydroepiandrosterone Sulfate	0-30	insulin	Homo sapiens	145-152
16256973-0	2006	Dehydroepiandrosterone sulfate (DHEA-S) distribution in Spanish prepuberal children: relationship with fasting plasma insulin concentrations and insulin resistance.	Dehydroepiandrosterone Sulfate	32-38	insulin	Homo sapiens	118-125
16256973-0	2006	Dehydroepiandrosterone sulfate (DHEA-S) distribution in Spanish prepuberal children: relationship with fasting plasma insulin concentrations and insulin resistance.	Dehydroepiandrosterone Sulfate	32-38	insulin	Homo sapiens	145-152
16256973-7	2006	DHEA-S correlates positively and significantly with weight, height, and BMI in all age intervals but the correlation between DHEA-S and insulin and HOMA is present only at the age of 6.5 in boys and 8 in girls.	Dehydroepiandrosterone Sulfate	125-131	insulin	Homo sapiens	136-143
16257192-5	2006	The substrate specificity of hOAT4 includes various steroid sulfates, such as beta-estradiol-3,17-disulfate, 17-beta-estradiol-3-sulfate, beta-estradiol-3-sulfate, and dehydroepiandrosterone-3-sulfate (DHEAS), but does not include p-aminohippuric acid (PAH) and tetraethylammonium (TEA).	Dehydroepiandrosterone Sulfate	202-207	solute carrier family 22 member 11	Homo sapiens	29-34
16618615-2	2006	We describe a 17-year-old female with virilization and elevated plasma testosterone, dehydroepiandrosterone sulfate (DHEAS) and aldosterone.	Dehydroepiandrosterone Sulfate	85-115	sulfotransferase family 2A member 1	Homo sapiens	117-122
17024678-4	2006	In situ microelectrophoretic application of the muscarinic M2 subtype cholinergic receptor agonist cis-dioxolane, DHEAS, and ES markedly reduced PPI in the dentate and CA1 that was blocked by the M2 receptor antagonist gallamine.	Dehydroepiandrosterone Sulfate	114-119	carbonic anhydrase 1	Homo sapiens	168-171
22061563-4	2006	HCG injection increased the levels of testicular steroids (androstenone, testosterone, dehydroepiandrosterone sulphate, oestrone sulphate and oestrone; p&lt;0.001), and indole levels in plasma and fat (p&lt;0.05).	Dehydroepiandrosterone Sulfate	87-118	hypertrichosis 2 (generalised, congenital)	Homo sapiens	0-3
16530336-3	2006	In hyperandrogenic women, there are elevated serum concentrations of androstenedione and testosterone and, in up to 50% of the women, dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	134-164	sulfotransferase family 2A member 1	Homo sapiens	166-171
16622721-1	2006	To assess adrenal function with respect to the presence or absence of steroid therapy, we investigated differences in the blood levels of adrenocorticotropic hormone (ACTH) and dehydroepiandrosterone sulfate (DHEAS) in relation to steroid (prednisolone) administration in 123 patients with rheumatoid arthritis (RA).	Dehydroepiandrosterone Sulfate	177-207	sulfotransferase family 2A member 1	Homo sapiens	209-214
16359813-11	2006	This transport function together with the localization of the ABCC11 protein in vicinity to GABAA receptors is consistent with a role of ABCC11 in dehydroepiandrosterone 3-sulfate release from neurons to sites of dehydroepiandrosterone 3-sulfate-mediated receptor modulation.	Dehydroepiandrosterone Sulfate	147-179	ATP binding cassette subfamily C member 11	Homo sapiens	62-68
16359813-11	2006	This transport function together with the localization of the ABCC11 protein in vicinity to GABAA receptors is consistent with a role of ABCC11 in dehydroepiandrosterone 3-sulfate release from neurons to sites of dehydroepiandrosterone 3-sulfate-mediated receptor modulation.	Dehydroepiandrosterone Sulfate	147-179	ATP binding cassette subfamily C member 11	Homo sapiens	137-143
16646293-5	2006	Both women with POF and postmenopausal subjects showed lower concentration of dehydroepiandrosterone-sulfate (DHEA-S) compared to fertile women.	Dehydroepiandrosterone Sulfate	78-108	POF1B actin binding protein	Homo sapiens	16-19
16646293-5	2006	Both women with POF and postmenopausal subjects showed lower concentration of dehydroepiandrosterone-sulfate (DHEA-S) compared to fertile women.	Dehydroepiandrosterone Sulfate	110-116	POF1B actin binding protein	Homo sapiens	16-19
16508124-1	2006	Dehydroepiandrosterone-sulfate (DHEA-S), the sulfated form of dehydroepiandrosterone, is the most abundant steroids in human, although its biological activities are seemingly weak.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-38
16541252-6	2006	SOAT specifically transports steroid sulfates such as oestrone-3-sulfate and dehydroepiandrosterone sulfate in a sodium-dependent manner, and is considered to play an important role for the cellular delivery of these prohormones in testes, placenta, adrenal gland and probably other peripheral tissues.	Dehydroepiandrosterone Sulfate	77-107	solute carrier family 10 member 6	Homo sapiens	0-4
16364377-0	2006	Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma 1 (sigma1) receptor: optical imaging study in rat hippocampal slices.	Dehydroepiandrosterone Sulfate	26-56	sigma non-opioid intracellular receptor 1	Rattus norvegicus	128-153
16364377-0	2006	Chronic administration of dehydroepiandrosterone sulfate (DHEAS) primes for facilitated induction of long-term potentiation via sigma 1 (sigma1) receptor: optical imaging study in rat hippocampal slices.	Dehydroepiandrosterone Sulfate	58-63	sigma non-opioid intracellular receptor 1	Rattus norvegicus	128-153
16364377-3	2006	In this study, we investigated the effects of chronic administration of DHEAS (20 mg/kg for 7 days) on the plasticity of Schaffer collateral-CA1 synapses by applying an optical recording technique on the hippocampal slices stained with voltage-sensitive dyes.	Dehydroepiandrosterone Sulfate	72-77	carbonic anhydrase 1	Rattus norvegicus	141-144
16364377-8	2006	Co-administration of the sigma 1 (sigma1) receptor antagonists, haloperidol or NE100, with DHEAS completely inhibited the DHEAS-facilitated LTP.	Dehydroepiandrosterone Sulfate	91-96	sigma non-opioid intracellular receptor 1	Rattus norvegicus	25-50
16364377-8	2006	Co-administration of the sigma 1 (sigma1) receptor antagonists, haloperidol or NE100, with DHEAS completely inhibited the DHEAS-facilitated LTP.	Dehydroepiandrosterone Sulfate	122-127	sigma non-opioid intracellular receptor 1	Rattus norvegicus	25-50
16364377-9	2006	However, acute administration of sigma1 receptor antagonists to the slices did not affect the induction of DHEAS-facilitated LTP, suggesting that sigma1 receptor is a key target of chronic actions of DHEAS but is not involved in the induction of DHEAS-facilitated LTP.	Dehydroepiandrosterone Sulfate	200-205	sigma non-opioid intracellular receptor 1	Rattus norvegicus	146-161
16364377-9	2006	However, acute administration of sigma1 receptor antagonists to the slices did not affect the induction of DHEAS-facilitated LTP, suggesting that sigma1 receptor is a key target of chronic actions of DHEAS but is not involved in the induction of DHEAS-facilitated LTP.	Dehydroepiandrosterone Sulfate	200-205	sigma non-opioid intracellular receptor 1	Rattus norvegicus	146-161
16364377-10	2006	Our findings provide evidence that chronically administered DHEAS plays a priming role in inducing a facilitated synaptic plasticity probably via a chronic activation of sigma1 receptor in rat hippocampal CA1 pyramidal cells.	Dehydroepiandrosterone Sulfate	60-65	sigma non-opioid intracellular receptor 1	Rattus norvegicus	170-185
16364377-10	2006	Our findings provide evidence that chronically administered DHEAS plays a priming role in inducing a facilitated synaptic plasticity probably via a chronic activation of sigma1 receptor in rat hippocampal CA1 pyramidal cells.	Dehydroepiandrosterone Sulfate	60-65	carbonic anhydrase 1	Rattus norvegicus	205-208
16300484-3	2005	Adrenal hormones dehydroepiandrosterone sulphate (DHEAS) and cortisol have opposing effects on the innate immune system, DHEAS enhances while cortisol suppresses immunity and the molar ratio of cortisol to DHEAS increases with age.	Dehydroepiandrosterone Sulfate	17-48	sulfotransferase family 2A member 1	Homo sapiens	50-55
31627493-1	2005	The purpose of the present study was to study the time course of changes in the levels of dehydroepiandrosterone sulfate (DHEAS) and 17-hydroxyprogesterone (17-HOP) in pregnant women in relation to the gestational time from the results of the screening made in Tyumen.	Dehydroepiandrosterone Sulfate	90-120	sulfotransferase family 2A member 1	Homo sapiens	122-127
16300484-3	2005	Adrenal hormones dehydroepiandrosterone sulphate (DHEAS) and cortisol have opposing effects on the innate immune system, DHEAS enhances while cortisol suppresses immunity and the molar ratio of cortisol to DHEAS increases with age.	Dehydroepiandrosterone Sulfate	17-48	sulfotransferase family 2A member 1	Homo sapiens	121-126
16300484-3	2005	Adrenal hormones dehydroepiandrosterone sulphate (DHEAS) and cortisol have opposing effects on the innate immune system, DHEAS enhances while cortisol suppresses immunity and the molar ratio of cortisol to DHEAS increases with age.	Dehydroepiandrosterone Sulfate	17-48	sulfotransferase family 2A member 1	Homo sapiens	121-126
16236806-1	2005	Human organic anion transporter 4 (OAT4) is an apical organic anion/dicarboxylate exchanger in the renal proximal tubules and mediates high-affinity transport of steroid sulfates such as estrone-3-sulfate (E1S) and dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	215-245	solute carrier family 22 member 11	Homo sapiens	6-33
16415544-0	2005	The effect of dehydroepiandrosterone sulfate (DHEAS) on myotonia: intracellular studies.	Dehydroepiandrosterone Sulfate	14-44	sulfotransferase family 2A member 1	Homo sapiens	46-51
16236806-1	2005	Human organic anion transporter 4 (OAT4) is an apical organic anion/dicarboxylate exchanger in the renal proximal tubules and mediates high-affinity transport of steroid sulfates such as estrone-3-sulfate (E1S) and dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	215-245	solute carrier family 22 member 11	Homo sapiens	35-39
16317133-3	2005	This study examined the cross-sectional association of fat intake with serum levels of estrone, estradiol, testosterone, and dehydroepiandrosterone sulfate (DHEAS) in women.	Dehydroepiandrosterone Sulfate	125-155	sulfotransferase family 2A member 1	Homo sapiens	157-162
16150593-4	2005	When mOAT5 was expressed in Xenopus oocytes, mOAT5 transported estrone sulfate, dehydroepiandrosterone sulfate and ochratoxin A.	Dehydroepiandrosterone Sulfate	80-110	solute carrier family 22 (organic anion transporter), member 19	Mus musculus	5-10
16150593-4	2005	When mOAT5 was expressed in Xenopus oocytes, mOAT5 transported estrone sulfate, dehydroepiandrosterone sulfate and ochratoxin A.	Dehydroepiandrosterone Sulfate	80-110	solute carrier family 22 (organic anion transporter), member 19	Mus musculus	45-50
16081670-4	2005	Our objective was to evaluate the effects of 20 naturally occurring flavonoids, and some of their corresponding glycosides, on the uptake of [3H]dehydroepiandrosterone sulfate (DHEAS) in OATP1B1-expressing and OATP1B1-negative HeLa cells.	Dehydroepiandrosterone Sulfate	177-182	solute carrier organic anion transporter family member 1B1	Homo sapiens	187-194
16259799-1	2005	BACKGROUND: Dehydroepiandrosterone sulphate (DHEAS) is a steroid that is increasingly being recognized as a potential drug of abuse in many countries.	Dehydroepiandrosterone Sulfate	12-43	sulfotransferase family 2A member 1	Homo sapiens	45-50
16521435-1	2005	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulphate (DHEAS) are secondary adrenal androgens, mainly produced in the reticular layer as well as in the gonads and in the central nervous system.	Dehydroepiandrosterone Sulfate	34-65	sulfotransferase family 2A member 1	Homo sapiens	67-72
16081670-4	2005	Our objective was to evaluate the effects of 20 naturally occurring flavonoids, and some of their corresponding glycosides, on the uptake of [3H]dehydroepiandrosterone sulfate (DHEAS) in OATP1B1-expressing and OATP1B1-negative HeLa cells.	Dehydroepiandrosterone Sulfate	177-182	solute carrier organic anion transporter family member 1B1	Homo sapiens	210-217
16081670-5	2005	Many of the tested flavonoids (including biochanin A, genistein, and epigallocatechin-3-gallate) significantly inhibited [3H]DHEAS uptake in a concentration-dependent manner in OATP1B1-expressing cells, with biochanin A being one of the most potent inhibitors with an IC50 of 11.3 +/- 3.22 microM.	Dehydroepiandrosterone Sulfate	125-130	solute carrier organic anion transporter family member 1B1	Homo sapiens	177-184
16079298-4	2005	When expressed in Xenopus laevis oocytes, rOat5 mediated the transport of sulfate conjugates of steroids such as estrone-3-sulfate (E(1)S; K(m) = 18.9 +/- 3.9 microM) and dehydroepiandrosterone sulfate (K(m) = 2.3 +/- 0.2 microM) in a sodium-independent manner, in addition to OTA.	Dehydroepiandrosterone Sulfate	171-201	solute carrier family 22, member 24	Rattus norvegicus	42-47
16821206-11	2005	In the group B the leptin /DHEAS (r=-0.40; p&lt;0.05) and leptin/PRL (r=0.51; p&lt;0.05) links were also present.	Dehydroepiandrosterone Sulfate	27-32	leptin	Homo sapiens	19-25
16246895-3	2005	When OSTalpha and OSTbeta are coexpressed in Xenopus oocytes, they are able to mediate transport of estrone 3-sulfate, dehydroepiandrosterone 3- sulfate, taurocholate, digoxin, and prostaglandin E2, indicating a role in the disposition of key cellular metabolites or signaling molecules.	Dehydroepiandrosterone Sulfate	119-152	solute carrier family 51 alpha subunit S homeolog	Xenopus laevis	5-13
16246895-3	2005	When OSTalpha and OSTbeta are coexpressed in Xenopus oocytes, they are able to mediate transport of estrone 3-sulfate, dehydroepiandrosterone 3- sulfate, taurocholate, digoxin, and prostaglandin E2, indicating a role in the disposition of key cellular metabolites or signaling molecules.	Dehydroepiandrosterone Sulfate	119-152	solute carrier family 51, beta subunit	Mus musculus	18-25
15821754-1	2005	1 Agonistic neurosteroids, including pregnenolone, dehydroepiandrosterone and its sulfate (DHEAS), caused rapid degranulation in measurements of beta-hexosaminidase (beta-HEX) release from a mast cell line, RBL-2H3.	Dehydroepiandrosterone Sulfate	91-96	O-GlcNAcase	Homo sapiens	145-164
16014403-0	2005	Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells.	Dehydroepiandrosterone Sulfate	98-128	corticotropin releasing hormone	Homo sapiens	0-31
16014403-0	2005	Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells.	Dehydroepiandrosterone Sulfate	98-128	corticotropin releasing hormone	Homo sapiens	33-36
16014403-0	2005	Corticotropin-releasing hormone (CRH) and urocortin act through type 1 CRH receptors to stimulate dehydroepiandrosterone sulfate production in human fetal adrenal cells.	Dehydroepiandrosterone Sulfate	98-128	corticotropin releasing hormone	Homo sapiens	71-74
16014403-1	2005	CONTEXT: Near term, the human fetal adrenal increases the production of cortisol and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	85-115	sulfotransferase family 2A member 1	Homo sapiens	117-122
16116338-1	2005	Although an inverse relationship between dehydroepiandrosterone sulfate (DHEAS) and coronary artery disease has been demonstrated in men, the vascular effects of DHEAS are not well defined.	Dehydroepiandrosterone Sulfate	41-71	sulfotransferase family 2A member 1	Homo sapiens	73-78
16039288-2	2005	We evaluated relationships between serum DHEA sulfate (DHEA-S) concentration and carotid atherosclerosis, as well as major cardiovascular risk factors, in men with type 2 diabetes.	Dehydroepiandrosterone Sulfate	41-53	sulfotransferase family 2A member 1	Homo sapiens	55-61
15934093-0	2005	Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency.	Dehydroepiandrosterone Sulfate	45-75	tumor necrosis factor	Homo sapiens	0-21
15934093-0	2005	Tumor necrosis factor inhibits conversion of dehydroepiandrosterone sulfate (DHEAS) to DHEA in rheumatoid arthritis synovial cells: a prerequisite for local androgen deficiency.	Dehydroepiandrosterone Sulfate	77-82	tumor necrosis factor	Homo sapiens	0-21
15934093-9	2005	Neutralization of TNF largely up-regulated the conversion of DHEAS to DHEA in RA, but not in OA.	Dehydroepiandrosterone Sulfate	61-66	tumor necrosis factor	Homo sapiens	18-21
15934093-11	2005	CONCLUSION: These data indicate that TNF inhibits the conversion of DHEAS to DHEA in RA synovial cells.	Dehydroepiandrosterone Sulfate	68-73	tumor necrosis factor	Homo sapiens	37-40
16014405-7	2005	MAIN OUTCOME MEASURES: The outcome measures included testosterone and dehydroepiandrosterone sulfate (DHEAS) at baseline and 1 yr later.	Dehydroepiandrosterone Sulfate	70-100	sulfotransferase family 2A member 1	Homo sapiens	102-107
16178776-1	2005	Steroid sulfatase (STS) is the only well characterized enzyme in human cells that is capable to desulfate estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) as a first step in the conversion of these precursors to active hormones.	Dehydroepiandrosterone Sulfate	134-164	steroid sulfatase	Homo sapiens	0-17
16178776-1	2005	Steroid sulfatase (STS) is the only well characterized enzyme in human cells that is capable to desulfate estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) as a first step in the conversion of these precursors to active hormones.	Dehydroepiandrosterone Sulfate	166-171	steroid sulfatase	Homo sapiens	0-17
15985487-0	2005	A common polymorphism in the CYP3A7 gene is associated with a nearly 50% reduction in serum dehydroepiandrosterone sulfate levels.	Dehydroepiandrosterone Sulfate	92-122	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	29-35
15985487-1	2005	CONTEXT: CYP3A7, expressed in the human fetal liver and normally silenced after birth, plays a major role in the 16alpha-hydroxylation of dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and estrone.	Dehydroepiandrosterone Sulfate	169-181	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	9-15
15985487-1	2005	CONTEXT: CYP3A7, expressed in the human fetal liver and normally silenced after birth, plays a major role in the 16alpha-hydroxylation of dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and estrone.	Dehydroepiandrosterone Sulfate	183-188	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	9-15
15985487-7	2005	RESULTS: In study groups 1 and 2, heterozygous CYP3A7*1C carriers had almost 50% lower DHEAS levels compared with homozygous carriers of the reference allele [study group 1, 1.74 +/- 0.25 vs. 3.33 +/- 0.15 micromol/liter (P = 0.02); study group 2, 2.09 +/- 0.08 vs. 1.08 +/- 0.12 micromol/liter (P < 0.001)].	Dehydroepiandrosterone Sulfate	87-92	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	47-53
15985487-10	2005	CONCLUSION: The CYP3A7*1C polymorphism causes the persistence of enzymatic activity of CYP3A7 during adult life, resulting in lower circulating DHEAS and estrone levels.	Dehydroepiandrosterone Sulfate	144-149	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	16-22
15985487-10	2005	CONCLUSION: The CYP3A7*1C polymorphism causes the persistence of enzymatic activity of CYP3A7 during adult life, resulting in lower circulating DHEAS and estrone levels.	Dehydroepiandrosterone Sulfate	144-149	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	87-93
15870132-7	2005	RESULTS: Stepwise regression analysis showed that after adjustment for age and body mass index, IMT was significantly correlated with blood pressure (BP) load (P = 0.03) and inversely with dehydroepiandrosterone sulfate (DHEAS) (P = 0.01).	Dehydroepiandrosterone Sulfate	189-219	sulfotransferase family 2A member 1	Homo sapiens	221-226
16092053-1	2005	Plasma dehydroepiandrosterone sulfate (DHEA-S) and testosterone levels both decline with age in healthy men.	Dehydroepiandrosterone Sulfate	7-37	sulfotransferase family 2A member 1	Homo sapiens	39-45
16019179-0	2005	Aging and season affect plasma dehydroepiandrosterone sulfate (DHEA-S) levels in a primate.	Dehydroepiandrosterone Sulfate	31-61	sulfotransferase family 2A member 1	Homo sapiens	63-69
16019179-1	2005	In humans, plasma concentration of dehydroepiandrosterone sulfate (DHEA-S) declines with age and is considered as a potential predictor of longevity.	Dehydroepiandrosterone Sulfate	35-65	sulfotransferase family 2A member 1	Homo sapiens	67-73
15996060-1	2005	OBJECTIVE: Androgens such as dehydroepiandrosterone sulfate (DHEAS) and testosterone are markedly lower in postmenopausal women with rheumatoid arthritis (RA) than in controls.	Dehydroepiandrosterone Sulfate	29-59	sulfotransferase family 2A member 1	Homo sapiens	61-66
15894035-2	2005	Some progesterone metabolites, including three pregnanolone isomers (PI), abate, while pregnenolone sulfate (PregS) and dehydroepiandrosterone sulfate (DHEAS) increase, alcohol tolerance.	Dehydroepiandrosterone Sulfate	120-150	sulfotransferase family 2A member 1	Homo sapiens	152-157
15821754-1	2005	1 Agonistic neurosteroids, including pregnenolone, dehydroepiandrosterone and its sulfate (DHEAS), caused rapid degranulation in measurements of beta-hexosaminidase (beta-HEX) release from a mast cell line, RBL-2H3.	Dehydroepiandrosterone Sulfate	91-96	O-GlcNAcase	Homo sapiens	166-174
15821754-3	2005	2 DHEAS-induced beta-HEX release was blocked by U-73122 or xestospongin C, but not by PTX or EGTA.	Dehydroepiandrosterone Sulfate	2-7	O-GlcNAcase	Homo sapiens	16-24
15821754-4	2005	DHEAS-induced beta-HEX release was also abolished by G(q/11)-AS, but not by G(q/11)-MS. Pharmacological analyses revealed that the neurosteroids stimulated a putative membrane receptor through activation of the novel G(q/11) and phospholipase C. 3 While representative endocrine-disrupting chemicals (EDCs) did not show any degranulation or nocifensive actions by themselves, they blocked the DHEAS-induced degranulation.	Dehydroepiandrosterone Sulfate	0-5	O-GlcNAcase	Homo sapiens	14-22
15821754-4	2005	DHEAS-induced beta-HEX release was also abolished by G(q/11)-AS, but not by G(q/11)-MS. Pharmacological analyses revealed that the neurosteroids stimulated a putative membrane receptor through activation of the novel G(q/11) and phospholipase C. 3 While representative endocrine-disrupting chemicals (EDCs) did not show any degranulation or nocifensive actions by themselves, they blocked the DHEAS-induced degranulation.	Dehydroepiandrosterone Sulfate	393-398	O-GlcNAcase	Homo sapiens	14-22
15901346-6	2005	Moreover, we observed that hOat2 mediates the transport of bumetanide, ES, glutarate, dehydroepiandrosterone sulfate, allopurinol, prostaglandin E2, 5-fluorouracil, paclitaxel and L-ascorbic acid.	Dehydroepiandrosterone Sulfate	86-116	solute carrier family 22 member 7	Homo sapiens	27-32
15943823-8	2005	Among White women with PCOS, DHEAS levels correlated negatively with BMI and fasting insulin.	Dehydroepiandrosterone Sulfate	29-34	insulin	Homo sapiens	85-92
15950640-9	2005	Adiponectin concentrations correlated inversely with body weight, BMI, fasting plasma glucose, serum insulin, Delta4-A, DHEA, DHEAS, and HOMA but correlated positively with serum T, SHBG, FAI, and glucose-to-insulin ratio.	Dehydroepiandrosterone Sulfate	126-131	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
15820420-1	2005	The aim of this study was to determine for the first time neurosteroid levels, dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) in particular, in a group of adult patients with autistic disorder and compare these levels with normal healthy individuals.	Dehydroepiandrosterone Sulfate	113-125	sulfotransferase family 2A member 1	Homo sapiens	127-133
15877298-1	2005	Association of serum dehydroepiandrosterone sulfate (DHEAS) levels with insulin resistance and impairment of insulin secretion have been reported.	Dehydroepiandrosterone Sulfate	21-51	sulfotransferase family 2A member 1	Homo sapiens	53-58
15877298-1	2005	Association of serum dehydroepiandrosterone sulfate (DHEAS) levels with insulin resistance and impairment of insulin secretion have been reported.	Dehydroepiandrosterone Sulfate	21-51	insulin	Homo sapiens	72-79
15781640-1	2005	The serum levels of an adrenal sex hormone, dehydroepiandrosterone sulfate (DHEA-S), are significantly more decreased in human myelomas compared with the reduction brought by physiologic decline with age.	Dehydroepiandrosterone Sulfate	44-74	sulfotransferase family 2A member 1	Homo sapiens	76-82
15816945-0	2005	Seizure frequency and cortisol and dehydroepiandrosterone sulfate (DHEAS) levels in women with epilepsy receiving antiepileptic drug treatment.	Dehydroepiandrosterone Sulfate	35-65	sulfotransferase family 2A member 1	Homo sapiens	67-72
15816945-3	2005	This cross-sectional observational study aimed to evaluating cortisol and dehydroepiandrosterone sulfate (DHEAS) levels in female epilepsy patients with different disease severity, as assessed by a seizure frequency score (SFS).	Dehydroepiandrosterone Sulfate	74-104	sulfotransferase family 2A member 1	Homo sapiens	106-111
29699212-6	2005	Serum leptin was positively correlated with body mass index, percentage of body fat, serum levels of dehydroepiandrosterone sulfate, testosterone, free testosterone, luteinizing hormone and prolactin.	Dehydroepiandrosterone Sulfate	101-131	leptin	Homo sapiens	6-12
15448171-8	2005	These results suggest that although BCRP is expressed at the BBB it plays a minor role in active efflux transport of DHEAS and mitoxantrone out of brain and that one or more GF120918-sensitive efflux transporters distinct from BCRP or P-gp contributes to the brain efflux of DHEAS and mitoxantrone.	Dehydroepiandrosterone Sulfate	117-122	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	36-40
15745935-9	2005	CONCLUSIONS: We conclude that in elderly men dependent on DHEAS levels, 44-72% of E2 and 34-54% of E1 originate directly or indirectly from the testes.	Dehydroepiandrosterone Sulfate	58-63	cystatin 12, pseudogene	Homo sapiens	82-91
15772904-8	2005	In conclusion, significantly higher basal and ACTH-stimulated levels of F and DHEA-S in PCOS compared with controls and patients with IH, reflect that adrenal hyperactivity also plays a role in hyperandrogenemia seen in PCOS.	Dehydroepiandrosterone Sulfate	78-84	proopiomelanocortin	Homo sapiens	46-50
15383738-0	2005	Decreased release of the angiogenic peptide vascular endothelial growth factor in Alzheimer"s disease: recovering effect with insulin and DHEA sulfate.	Dehydroepiandrosterone Sulfate	138-150	vascular endothelial growth factor A	Homo sapiens	44-78
15383738-8	2005	The incubation with LPS and DHEAS significantly increased, in a dose-dependent manner, VEGF levels in AD as well as in healthy subjects of young and old age and in VAD patients.	Dehydroepiandrosterone Sulfate	28-33	vascular endothelial growth factor A	Homo sapiens	87-91
15383738-12	2005	On the contrary, insulin and DHEAS could have beneficial effects in AD, as well as in VAD and in physiological aging, by increasing, in a dose-dependent fashion, VEGF availability by peripheral and resident immune and endothelial cells, so contributing to increase its circulating pool.	Dehydroepiandrosterone Sulfate	29-34	vascular endothelial growth factor A	Homo sapiens	162-166
16331433-7	2005	Fibrinogen and white blood cell count also were associated positively with estrone, androstenedione, and testosterone (and fibrinogen also with dehydroepiandrosterone sulfate).	Dehydroepiandrosterone Sulfate	144-174	fibrinogen beta chain	Homo sapiens	0-10
16331433-7	2005	Fibrinogen and white blood cell count also were associated positively with estrone, androstenedione, and testosterone (and fibrinogen also with dehydroepiandrosterone sulfate).	Dehydroepiandrosterone Sulfate	144-174	fibrinogen beta chain	Homo sapiens	123-133
15448171-8	2005	These results suggest that although BCRP is expressed at the BBB it plays a minor role in active efflux transport of DHEAS and mitoxantrone out of brain and that one or more GF120918-sensitive efflux transporters distinct from BCRP or P-gp contributes to the brain efflux of DHEAS and mitoxantrone.	Dehydroepiandrosterone Sulfate	275-280	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	36-40
15562203-4	2004	RESEARCH DESIGN AND METHODS: Relationships of urinary albumin excretion to serum DHEA sulfate (DHEA-S) concentration and to major cardiovascular risk factors, including blood pressure, serum lipid concentration, glycemic control (HbA1c), and BMI, were investigated in 357 consecutive men with type 2 diabetes.	Dehydroepiandrosterone Sulfate	81-93	sulfotransferase family 2A member 1	Homo sapiens	95-101
16399356-2	2005	Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not only in their incorporation and metabolism, but also in the controls of estrogen activity by regulating the binding potential of estrogen as to its receptor through sulfoconjugation and desulfation reactions.	Dehydroepiandrosterone Sulfate	79-111	arylsulfatase family member H	Homo sapiens	122-131
16399357-1	2005	Human steroid sulfatase (STS) is an enzyme that hydrolyzes several sulfated steroids, such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate, and results in the production of active substances.	Dehydroepiandrosterone Sulfate	111-141	steroid sulfatase	Homo sapiens	6-23
15579756-2	2004	This study examined the distribution of total and free estradiol, FSH, and dehydroepiandrosterone sulfate (DHEAS) by age and sex and associations of these hormones with body mass index (BMI), lifestyle factors, and chronic diseases.	Dehydroepiandrosterone Sulfate	75-105	sulfotransferase family 2A member 1	Homo sapiens	107-112
15588238-0	2004	A longitudinal study of dehydroepiandrosterone sulphate (DHEAS) change in older men and women: the Rancho Bernardo Study.	Dehydroepiandrosterone Sulfate	24-55	sulfotransferase family 2A member 1	Homo sapiens	57-62
15588238-1	2004	OBJECTIVE: To examine the age-related and sex-specific rates and determinants of change in endogenous dehydroepiandrosterone sulphate (DHEAS) levels in older community-dwelling adults, taking into account regression to the mean.	Dehydroepiandrosterone Sulfate	102-133	sulfotransferase family 2A member 1	Homo sapiens	135-140
15084485-4	2004	Culturing the cells with highly purified hCG resulted in a time- and dose-dependent significant increase in dehydroepiandrosterone sulfate (DHEAS) secretion as compared with the controls.	Dehydroepiandrosterone Sulfate	108-138	chorionic gonadotropin subunit beta 5	Homo sapiens	41-44
15624041-1	2004	BACKGROUND AND PURPOSE: To investigate the change in serum dehydroepiandrosterone sulfate (DHEAS) and androstenedione concentrations during childhood and to clarify the relationship between adrenarche and gonadarche.	Dehydroepiandrosterone Sulfate	59-89	sulfotransferase family 2A member 1	Homo sapiens	91-96
15717807-0	2004	[A relationship between dehydroepiandrosterone sulphate and insulin resistance in obese men and women].	Dehydroepiandrosterone Sulfate	24-55	insulin	Homo sapiens	60-67
15717807-1	2004	UNLABELLED: The aim of our study was to investigate if there is any significant relationship between adrenal steroid hormone dehydroepiandrosterone-sulphate (DHEAS) and insulin resistance, as there are some previous signs in the literature suggesting such relationship but the results are not conclusive.	Dehydroepiandrosterone Sulfate	125-156	sulfotransferase family 2A member 1	Homo sapiens	158-163
15717807-1	2004	UNLABELLED: The aim of our study was to investigate if there is any significant relationship between adrenal steroid hormone dehydroepiandrosterone-sulphate (DHEAS) and insulin resistance, as there are some previous signs in the literature suggesting such relationship but the results are not conclusive.	Dehydroepiandrosterone Sulfate	125-156	insulin	Homo sapiens	169-176
15476661-3	2004	The physiological hormone dehydroepiandrosterone sulfate (DHEAS) is a potent inhibitor of G6PD activity, and G6PD deficiency is known to exert antimalaria protection.	Dehydroepiandrosterone Sulfate	26-56	glucose-6-phosphate dehydrogenase 2	Mus musculus	90-94
15476661-3	2004	The physiological hormone dehydroepiandrosterone sulfate (DHEAS) is a potent inhibitor of G6PD activity, and G6PD deficiency is known to exert antimalaria protection.	Dehydroepiandrosterone Sulfate	58-63	glucose-6-phosphate dehydrogenase 2	Mus musculus	90-94
15476661-4	2004	This study aimed to investigate the ability of DHEAS to enhance the antimalarial activity of CQ, via an inhibition of G6PD activity and GSH synthesis.	Dehydroepiandrosterone Sulfate	47-52	glucose-6-phosphate dehydrogenase 2	Mus musculus	118-122
15476661-10	2004	This reduction of parasitaemia and improvement of the survival of infected mice were associated with intra-parasite depletion of GSH and inhibition of G6PD activity due to DHEAS action.	Dehydroepiandrosterone Sulfate	172-177	glucose-6-phosphate dehydrogenase 2	Mus musculus	151-155
15666810-0	2004	Dehydroepiandrosterone sulphate (DHEAS) inhibits growth of human vascular endothelial cells.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-38
15666810-1	2004	Dehydroepiandrosterone sulphate (DHEAS) is a steroid product of the adrenal gland, which circulates in high concentrations, but whose functions are largely unknown.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-38
15665656-1	2004	OBJECTIVE: To investigate the relationship between serum dehydroepiandrosterone sulfate (DHEAS) concentration and bone mineral density (BMD), lipids, and hormone replacement therapy (HRT) in postmenopausal women.	Dehydroepiandrosterone Sulfate	57-87	sulfotransferase family 2A member 1	Homo sapiens	89-94
15635500-1	2004	During most of gestation, the fetal adrenal gland is almost solely dedicated to the production of dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	98-128	sulfotransferase family 2A member 1	Homo sapiens	130-136
15516806-9	2004	Dehydroepiandrosterone sulfate and small neutral amino acids undergo brain-to-blood efflux transport mediated by organic anion transporting polypeptide 2 and ATA2, respectively.	Dehydroepiandrosterone Sulfate	0-30	solute carrier organic anion transporter family member 1B1	Homo sapiens	113-153
15516806-9	2004	Dehydroepiandrosterone sulfate and small neutral amino acids undergo brain-to-blood efflux transport mediated by organic anion transporting polypeptide 2 and ATA2, respectively.	Dehydroepiandrosterone Sulfate	0-30	solute carrier family 38 member 2	Homo sapiens	158-162
15474441-9	2004	IGFBP-2 and -4 expression decreased by 1.9- and 1.6-fold after DHEAS stimulus, although this was not statistically significant.	Dehydroepiandrosterone Sulfate	63-68	insulin like growth factor binding protein 2	Homo sapiens	0-14
15353002-2	2004	We now report on the relationships between serum estrone sulfate and dehydroepiandrosterone sulfate (DHEAS) levels after 4 weeks of moderate alcohol supplementation, and compare the results to the 8 weeks data to elucidate time-to-effect differences.	Dehydroepiandrosterone Sulfate	69-99	sulfotransferase family 2A member 1	Homo sapiens	101-106
15464829-8	2004	These findings suggest that DHEAS is more effective in reversing the cognitive impairments associated with overexpression of Abeta than with diabetes.	Dehydroepiandrosterone Sulfate	28-33	amyloid beta (A4) precursor protein	Mus musculus	125-130
15467183-9	2004	Dehydroepiandrosterone sulfate and small neutral amino acids undergo brain-to-blood efflux transport mediated by organic anion transporting polypeptide 2 and ATA2, respectively.	Dehydroepiandrosterone Sulfate	0-30	solute carrier organic anion transporter family member 1B1	Homo sapiens	113-153
15467183-9	2004	Dehydroepiandrosterone sulfate and small neutral amino acids undergo brain-to-blood efflux transport mediated by organic anion transporting polypeptide 2 and ATA2, respectively.	Dehydroepiandrosterone Sulfate	0-30	solute carrier family 38 member 2	Homo sapiens	158-162
15482786-0	2004	Role of a CYP17 polymorphism in the regulation of circulating dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome.	Dehydroepiandrosterone Sulfate	62-92	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	10-15
19330152-0	2004	Enhancement of Cognitive and Electrophysiological Measures of Hippocampal Functioning in Rats by a Low, But Not High, Dose of Dehydroepiandrosterone Sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	126-156	sulfotransferase family 2A member 1	Homo sapiens	158-163
19330152-1	2004	Dehydroepiandrosterone sulfate (DHEAS) is a steroid hornone that is synthesized, de novo, in the brain.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
15488954-2	2004	In contrast to cortisol, dehydroepiandrosterone-sulfate (DHEA-S) has been less extensively studied in depressed patients.	Dehydroepiandrosterone Sulfate	25-55	sulfotransferase family 2A member 1	Homo sapiens	57-63
15208301-4	2004	In contrast, the production of dehydroepiandrosterone (DHEA) and DHEA sulfate in the adrenal reticularis is inversely correlated with the expression of HSD3B2.	Dehydroepiandrosterone Sulfate	65-77	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Homo sapiens	152-158
15208301-7	2004	Microarray analysis of cortisol- versus DHEA sulfate-producing adrenal tissue demonstrated that NGIFB paralleled expression of HSD3B2 with expression much higher in cortisol-producing adrenal tissue; this observation was also demonstrated using real time reverse transcriptase-PCR analysis.	Dehydroepiandrosterone Sulfate	40-52	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Homo sapiens	127-133
15289280-1	2004	CONTEXT: Recently, a growing body of research has provided evidence that dehydroepiandrosterone sulfate (DHEA-S) is involved in an organism"s response to stress and that it may provide beneficial behavioral and neurotrophic effects.	Dehydroepiandrosterone Sulfate	73-103	sulfotransferase family 2A member 1	Homo sapiens	105-111
15084485-4	2004	Culturing the cells with highly purified hCG resulted in a time- and dose-dependent significant increase in dehydroepiandrosterone sulfate (DHEAS) secretion as compared with the controls.	Dehydroepiandrosterone Sulfate	108-138	sulfotransferase family 2A member 1	Homo sapiens	140-145
15196791-0	2004	A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase.	Dehydroepiandrosterone Sulfate	23-53	FBJ osteosarcoma oncogene	Mus musculus	121-126
15196791-7	2004	These results showed that DHEAS prevented the development of morphine tolerance and dependence and suggested that the attenuating effects of DHEAS might result from the regulation of c-fos mRNA expression, which is possibly involved the signaling activation of ERK, but not of cAMP pathway.	Dehydroepiandrosterone Sulfate	26-31	mitogen-activated protein kinase 1	Mus musculus	261-264
15196791-7	2004	These results showed that DHEAS prevented the development of morphine tolerance and dependence and suggested that the attenuating effects of DHEAS might result from the regulation of c-fos mRNA expression, which is possibly involved the signaling activation of ERK, but not of cAMP pathway.	Dehydroepiandrosterone Sulfate	141-146	FBJ osteosarcoma oncogene	Mus musculus	183-188
15196791-7	2004	These results showed that DHEAS prevented the development of morphine tolerance and dependence and suggested that the attenuating effects of DHEAS might result from the regulation of c-fos mRNA expression, which is possibly involved the signaling activation of ERK, but not of cAMP pathway.	Dehydroepiandrosterone Sulfate	141-146	mitogen-activated protein kinase 1	Mus musculus	261-264
15194576-2	2004	Adrenal androgens such as androstenedione (ASD) and dehydroepiandrosterone (DHEA) sulphate are low, which partly depends on the influence of TNF in chronic inflammatory diseases.	Dehydroepiandrosterone Sulfate	52-90	tumor necrosis factor	Homo sapiens	141-144
15370368-5	2004	RESULTS: It was found that the androgens testosterone, dihydrotestosterone, dehydroepiandrosterone and dehydroepiandrosterone-sulfate and 17beta-estradiol were able to inhibit interleukin-1beta-induced NO production in rabbit lacrimal gland acinar cells at physiological concentrations, while progesterone was not able to inhibit NO production.	Dehydroepiandrosterone Sulfate	103-133	interleukin-1 beta	Oryctolagus cuniculus	176-193
15240630-1	2004	Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS), the representative sex steroid precursors, are postulated to have antiinflammatory effects, although the molecular background remains unknown.	Dehydroepiandrosterone Sulfate	34-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
15249140-0	2004	DHEA and DHEA sulfate differentially regulate neural androgen receptor and its transcriptional activity.	Dehydroepiandrosterone Sulfate	9-21	androgen receptor	Mus musculus	53-70
15196791-0	2004	A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase.	Dehydroepiandrosterone Sulfate	23-53	mitogen-activated protein kinase 1	Mus musculus	152-197
15196791-4	2004	The expression of c-fos mRNA was observed in the frontal cortex and thalamus of mice showing signs of naloxone-precipitated withdrawal, while the expression of c-fos mRNA was significantly diminished by co-administration of DHEAS with morphine.	Dehydroepiandrosterone Sulfate	224-229	FBJ osteosarcoma oncogene	Mus musculus	18-23
15196791-4	2004	The expression of c-fos mRNA was observed in the frontal cortex and thalamus of mice showing signs of naloxone-precipitated withdrawal, while the expression of c-fos mRNA was significantly diminished by co-administration of DHEAS with morphine.	Dehydroepiandrosterone Sulfate	224-229	FBJ osteosarcoma oncogene	Mus musculus	160-165
15196791-6	2004	Interestingly, repeated co-administration of DHEAS with morphine prevented the withdrawal-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 2 in the frontal cortex.	Dehydroepiandrosterone Sulfate	45-50	mitogen-activated protein kinase 1	Mus musculus	117-170
15196791-7	2004	These results showed that DHEAS prevented the development of morphine tolerance and dependence and suggested that the attenuating effects of DHEAS might result from the regulation of c-fos mRNA expression, which is possibly involved the signaling activation of ERK, but not of cAMP pathway.	Dehydroepiandrosterone Sulfate	26-31	FBJ osteosarcoma oncogene	Mus musculus	183-188
15145259-1	2004	OBJECTIVES: To study the relationship between maternal endogenous dehydroepiandrosterone sulfate (DHEAS) levels, success of labor induction, and Bishop scores in postterm pregnancies.	Dehydroepiandrosterone Sulfate	66-96	sulfotransferase family 2A member 1	Homo sapiens	98-103
15181086-8	2004	In addition, ARE-1/1 subjects had significantly lower serum concentrations of dehydroepiandrosterone sulfate compared with ARE-2/2 subjects (4.2 +/- 0.3 vs. 6.6 +/- 0.7 micromol/liter) and a trend toward lower levels of free testosterone (78.8 +/- 6.5 vs. 114.1 +/- 30.8 pmol/liter).	Dehydroepiandrosterone Sulfate	78-108	VPS52 subunit of GARP complex	Homo sapiens	13-18
15139980-1	2004	OBJECTIVES: To evaluate plasma levels of dehydroepiandrosterone sulphate (DHEAS) in a cohort of HIV-infected patients and to analyse factors associated with DHEAS levels.	Dehydroepiandrosterone Sulfate	41-72	sulfotransferase family 2A member 1	Homo sapiens	74-79
15123757-1	2004	BACKGROUND: It has been suggested that the reduced production of dehydroepiandrosterone sulfate (DHEAS) may be partially responsible for the decline of muscle strength and mass that often occurs with aging.	Dehydroepiandrosterone Sulfate	65-95	sulfotransferase family 2A member 1	Homo sapiens	97-102
15365225-3	2004	METHODS: Dehydroepiandrosterone sulfate (DHEA-S) serum concentrations were measured in 80 patients being treated with amitriptyline (AMI) or paroxetine (PAROX) for a period of 35 days.	Dehydroepiandrosterone Sulfate	9-39	sulfotransferase family 2A member 1	Homo sapiens	41-47
15132725-2	2004	Dehydroepiandrosterone sulfate (DHEA-S) is the most abundant adrenal androgen and estrogen precursor.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-38
15020217-6	2004	When expressed in Xenopus laevis oocytes, Soat shows transport function for estrone-3-sulfate (Km = 31 microM, Vmax = 5557 fmol/oocyte/30 min) and dehydroepiandrosterone sulfate (Km = 30 microM, Vmax = 5682 fmol/oocyte/30 min).	Dehydroepiandrosterone Sulfate	147-177	solute carrier family 10 member 6	Rattus norvegicus	42-46
15195991-0	2004	Serum levels of insulin-like growth factor-I (IGF-I) and dehydroepiandrosterone sulfate (DHEA-S), and their relationships with serum interleukin-6, in the geriatric syndrome of frailty.	Dehydroepiandrosterone Sulfate	57-87	sulfotransferase family 2A member 1	Homo sapiens	89-95
15083066-11	2004	Dehydroepiandrosterone-3-sulphate and 17beta-glucuronosyl oestradiol were transported with similar kinetics by MRP3 and MRP3-ArgHis.	Dehydroepiandrosterone Sulfate	0-33	ATP binding cassette subfamily B member 4	Homo sapiens	111-115
15083066-11	2004	Dehydroepiandrosterone-3-sulphate and 17beta-glucuronosyl oestradiol were transported with similar kinetics by MRP3 and MRP3-ArgHis.	Dehydroepiandrosterone Sulfate	0-33	ATP binding cassette subfamily B member 4	Homo sapiens	120-124
14967152-1	2004	Dehydroepiandrosterone sulfate (DHEAS) is a 19-carbon steroid, situated along the steroid metabolic pathway.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
15120419-1	2004	BACKGROUND: Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) are the major steroid hormones secreted by the adrenal gland.	Dehydroepiandrosterone Sulfate	46-58	sulfotransferase family 2A member 1	Homo sapiens	60-65
14975704-3	2004	We here examined the pharmacological efficacy of igmesine and (+)-SKF-10,047 and the sigma(1) receptor-related neuroactive steroid dehydroepiandrosterone sulfate, in rats infused intracerebroventricularly during 14 days with the beta-amyloid-(1-40) protein and then submitted to the conditioned fear stress test.	Dehydroepiandrosterone Sulfate	131-161	sigma non-opioid intracellular receptor 1	Rattus norvegicus	85-102
14610227-5	2004	Dehydroepiandrosterone-sulfate, estrone-3-sulfate, and fexofenadine were transported by OATP-B at both neutral and acidic pH, whereas estradiol-17beta-glucuronide, acetic acid, and lactic acid were not transported at all.	Dehydroepiandrosterone Sulfate	0-30	solute carrier organic anion transporter family member 2B1	Homo sapiens	88-94
15287512-17	2004	In addition, 16alpha-hydroxylase and P-450arom convert DHEA-S to estriol.	Dehydroepiandrosterone Sulfate	55-61	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	37-46
15036224-8	2004	After multivariate adjustment, higher plasma levels of dehydroepiandrosterone sulfate (DHEAS) were associated with a higher prevalence of soft drusen (OR = 1.21; 95% CI = 1.01-1.44).	Dehydroepiandrosterone Sulfate	55-85	sulfotransferase family 2A member 1	Homo sapiens	87-92
15036391-0	2004	Dehydroepiandrosterone sulfate (DHEAS) and health: does the relationship differ by sex?	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
15001603-2	2004	This study examines whether the course of adrenarche [rise of serum dehydroepiandrosterone sulfate (DHEAS)] and pubarche (Tanner stage PH2) is independent from ovarian function.	Dehydroepiandrosterone Sulfate	68-98	sulfotransferase family 2A member 1	Homo sapiens	100-105
14764786-3	2004	In later life, one of the questions that might arise is: Do short children born SGA have higher serum dehydroepiandrosterone sulfate (DHEAS) levels than their peers?	Dehydroepiandrosterone Sulfate	102-132	sulfotransferase family 2A member 1	Homo sapiens	134-139
14718276-1	2004	HYPOTHESIS: Dehydroepiandrosterone sulfate (DHEA-S) comediates breast cancer progression via estrogen receptors (ERs) and androgen receptors (ARs).	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-50
15292672-1	2004	There is evidence that children with antisocial behaviors have increased plasma levels of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) and either a decreased level of another adrenal steroid, cortisol, or a decreased cortisol responsivity to stress.	Dehydroepiandrosterone Sulfate	111-141	sulfotransferase family 2A member 1	Homo sapiens	143-149
15545016-1	2004	Homocysteine (HC) and dehydroepiandrosterone sulphate (DHEAS) plasma levels have been evaluated in groups of male and female patients with Parkinson"s disease (PD) and in a group of female patients with Alzheimer"s disease (AD) and compared with the corresponding plasma levels observed in a group of age-matched subjects.	Dehydroepiandrosterone Sulfate	22-53	sulfotransferase family 2A member 1	Homo sapiens	55-60
14600408-1	2003	We have investigated the serum levels of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) in type II collagen (CII)-induced arthritis (CIA) DBA/1J mice, an experimental model of human rheumatoid arthritis (RA).	Dehydroepiandrosterone Sulfate	75-87	nuclear receptor coactivator 5	Mus musculus	99-145
14600408-1	2003	We have investigated the serum levels of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) in type II collagen (CII)-induced arthritis (CIA) DBA/1J mice, an experimental model of human rheumatoid arthritis (RA).	Dehydroepiandrosterone Sulfate	89-94	nuclear receptor coactivator 5	Mus musculus	99-145
12660303-8	2003	These results suggest that the renal uptake of 2,4-D is mainly accounted for by rOat1 and the uptake of PCG and DHEAS by rOat3, and rOat3 is partly involved in the renal uptake of temocaprilat and estrone sulfate.	Dehydroepiandrosterone Sulfate	112-117	solute carrier family 22 member 8	Rattus norvegicus	121-126
14732303-12	2003	However, high levels of dehydroepiandrosterone sulfate (DHEAS) were associated with a reduced risk of cataract (OR=0.79; 95% CI: 0.63-0.99).	Dehydroepiandrosterone Sulfate	24-54	sulfotransferase family 2A member 1	Homo sapiens	56-61
12959982-11	2003	These results suggest that the adrenal uses GATA-6 to enhance transcription of steroid-metabolizing enzymes needed to produce dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	126-156	GATA binding protein 6	Homo sapiens	44-50
14580861-1	2003	Numerous studies have suggested important and varying roles for dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) in primate physiological functions.	Dehydroepiandrosterone Sulfate	98-128	sulfotransferase family 2A member 1	Homo sapiens	130-136
12969781-10	2003	Both CYb5 and POR cofactors may up-regulate 17alpha-hydroxylase/17,20 lyase activity and thus DHEA sulfate production in the HFA.	Dehydroepiandrosterone Sulfate	94-106	cytochrome b5 type A	Homo sapiens	5-9
12969781-10	2003	Both CYb5 and POR cofactors may up-regulate 17alpha-hydroxylase/17,20 lyase activity and thus DHEA sulfate production in the HFA.	Dehydroepiandrosterone Sulfate	94-106	cytochrome p450 oxidoreductase	Homo sapiens	14-17
12677006-8	2003	These data suggest that rat GST-1 and GST-2 might be one of the molecular entities responsible for transporting dehydroepiandrosterone sulfate and thyroid hormones involved in the regulation of sex steroid transportation and spermatogenesis in the gonad.	Dehydroepiandrosterone Sulfate	112-142	solute carrier organic anion transporter family member 6B1	Rattus norvegicus	28-33
12677006-8	2003	These data suggest that rat GST-1 and GST-2 might be one of the molecular entities responsible for transporting dehydroepiandrosterone sulfate and thyroid hormones involved in the regulation of sex steroid transportation and spermatogenesis in the gonad.	Dehydroepiandrosterone Sulfate	112-142	solute carrier organic anion transporter family, member 6c1	Rattus norvegicus	38-43
12660303-4	2003	rOat3-expressing cells showed significant uptake of temocaprilat (Km = 1.4 microM), estrone sulfate (Km = 5.3 microM), dehydroepiandrosterone sulfate (DHEAS; Km = 12 microM), and benzylpenicillin (PCG; Km = 85 microM).	Dehydroepiandrosterone Sulfate	119-149	solute carrier family 22 member 8	Rattus norvegicus	0-5
12660303-4	2003	rOat3-expressing cells showed significant uptake of temocaprilat (Km = 1.4 microM), estrone sulfate (Km = 5.3 microM), dehydroepiandrosterone sulfate (DHEAS; Km = 12 microM), and benzylpenicillin (PCG; Km = 85 microM).	Dehydroepiandrosterone Sulfate	151-156	solute carrier family 22 member 8	Rattus norvegicus	0-5
14595703-8	2003	Furthermore, sulphate conjugates, such as oestrone sulphate and dehydroepiandrosterone sulphate, inhibited the uptake of indoxyl sulphate to a greater extent than PAH.	Dehydroepiandrosterone Sulfate	64-95	phenylalanine hydroxylase	Rattus norvegicus	163-166
14552823-1	2003	A simple method for simultaneous determination of androstenediol 3-sulfate (Adiol-3S) and dehydroepiandrosterone sulfate (DHEA-S) in human serum using isotope diluted liquid chromatography-electrospray ionization-ion trap-mass spectrometry (LC-ESI-ion trap-MS) was developed.	Dehydroepiandrosterone Sulfate	90-120	sulfotransferase family 2A member 1	Homo sapiens	122-128
14609305-2	2003	STUDY OBJECTIVE: It has been suggested that low levels of dehydroepiandrosterone sulphate (DHEAS) are predictive for cardiovascular diseases in men.	Dehydroepiandrosterone Sulfate	58-89	sulfotransferase family 2A member 1	Homo sapiens	91-96
12960018-12	2003	These data indicate allopregnanolone increases and DHEAS decreases responsiveness of GnRH neurons to activation of GABAA receptors by differentially modulating current flow through GABAA receptor chloride channels.	Dehydroepiandrosterone Sulfate	51-56	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	115-120
12960018-12	2003	These data indicate allopregnanolone increases and DHEAS decreases responsiveness of GnRH neurons to activation of GABAA receptors by differentially modulating current flow through GABAA receptor chloride channels.	Dehydroepiandrosterone Sulfate	51-56	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	181-186
12967339-6	2003	Treatment of cultured adrenocortical carcinoma NCI-H295R cells with activin A inhibited steroidogenic acute regulatory protein and 17alpha-hydroxylase/17,20-lyase mRNA accumulation as evaluated by the Northern blot technique, and decreased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate secretion as determined by specific enzyme immunoassays.	Dehydroepiandrosterone Sulfate	294-324	inhibin subunit beta E	Homo sapiens	68-75
14577864-7	2003	The most effective dose of DHEAS in the MWM was 10 mg/kg, while in the GC it was 20 mg/kg, in TAR 5 mg/kg, and all doses, except for vehicle, were effective at reducing injury-induced SMB hyperactivity.	Dehydroepiandrosterone Sulfate	27-32	trace amine-associated receptor 5	Rattus norvegicus	94-99
12912747-0	2003	Dehydroepiandrosterone sulfate causes proliferation of estrogen receptor-positive breast cancer cells despite treatment with fulvestrant.	Dehydroepiandrosterone Sulfate	0-30	estrogen receptor 1	Homo sapiens	55-72
12912747-1	2003	HYPOTHESIS: Dehydroepiandrosterone sulfate (DHEA-S) causes a proliferation of estrogen receptor (ER)-positive breast cancer cells, even with tamoxifen citrate blockade.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-50
12912747-1	2003	HYPOTHESIS: Dehydroepiandrosterone sulfate (DHEA-S) causes a proliferation of estrogen receptor (ER)-positive breast cancer cells, even with tamoxifen citrate blockade.	Dehydroepiandrosterone Sulfate	12-42	estrogen receptor 1	Homo sapiens	78-95
12912747-1	2003	HYPOTHESIS: Dehydroepiandrosterone sulfate (DHEA-S) causes a proliferation of estrogen receptor (ER)-positive breast cancer cells, even with tamoxifen citrate blockade.	Dehydroepiandrosterone Sulfate	12-42	estrogen receptor 1	Homo sapiens	97-99
12915699-0	2003	Effects of dehydroepiandrosterone-sulfate on the Apo E genotype influence on plasma lipid levels in prepubertal children.	Dehydroepiandrosterone Sulfate	11-41	apolipoprotein E	Homo sapiens	49-54
12915699-4	2003	However, there is an important difference in Dehydroepiandrosterone-sulfate (DHEA-S) levels between pre-pubertal boys and girls.	Dehydroepiandrosterone Sulfate	45-75	sulfotransferase family 2A member 1	Homo sapiens	77-83
14651593-7	2003	There was a significant inverse correlation between DHEA-S and IL-6, TNF-alpha, and CRP concentrations.	Dehydroepiandrosterone Sulfate	52-58	interleukin 6	Homo sapiens	63-67
14651593-7	2003	There was a significant inverse correlation between DHEA-S and IL-6, TNF-alpha, and CRP concentrations.	Dehydroepiandrosterone Sulfate	52-58	tumor necrosis factor	Homo sapiens	69-78
14651593-7	2003	There was a significant inverse correlation between DHEA-S and IL-6, TNF-alpha, and CRP concentrations.	Dehydroepiandrosterone Sulfate	52-58	C-reactive protein	Homo sapiens	84-87
12939667-2	2003	OBJECTIVE: Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) are the most abundant steroids in human plasma.	Dehydroepiandrosterone Sulfate	45-57	sulfotransferase family 2A member 1	Homo sapiens	59-65
12939667-5	2003	Therefore, this study aims to determine the relationship of plasma dehydroepiandrosterone sulfate (DHEA-S) levels with respect to obesity, fasting insulin and glucose levels in a cohort of obese and normal weight healthy Saudi women.	Dehydroepiandrosterone Sulfate	67-97	sulfotransferase family 2A member 1	Homo sapiens	99-105
12939667-5	2003	Therefore, this study aims to determine the relationship of plasma dehydroepiandrosterone sulfate (DHEA-S) levels with respect to obesity, fasting insulin and glucose levels in a cohort of obese and normal weight healthy Saudi women.	Dehydroepiandrosterone Sulfate	67-97	insulin	Homo sapiens	147-154
12854087-4	2003	Among pubertal girls, dehydroepiandrosterone sulfate (DHEAS) levels were significantly associated with decreased parasite density, even after adjustment for age.	Dehydroepiandrosterone Sulfate	22-52	sulfotransferase family 2A member 1	Homo sapiens	54-59
12727558-1	2003	BACKGROUND: We investigated the stimulatory potential of dehydroepiandrosterone sulfate (DHEA-S) on tamoxifen-treated cells and assessed its effect on cancer progression in the adjuvant setting.	Dehydroepiandrosterone Sulfate	57-87	sulfotransferase family 2A member 1	Homo sapiens	89-95
12699442-10	2003	Following GH replacement therapy, median levels of serum DHEAS levels rose from 1.5 micro mol/l (0.6-2.7 micro mol/l) to 1.9 micro mol/l (1.9-3.9 micro mol/l) in ACTH-sufficient patients, increasing in 11 of the 13 patients (P &lt; 0.02).	Dehydroepiandrosterone Sulfate	57-62	proopiomelanocortin	Homo sapiens	162-166
12699442-12	2003	In contrast, baseline serum DHEAS levels [0.5 micro mol/l (0.4-1.2 micro mol/l)] declined in or from the measurable range in 47% of ACTH-deficient patients [median -16%; range -36-0] and only in one patient a + 0.2 micro mol/l increase was observed.	Dehydroepiandrosterone Sulfate	28-33	proopiomelanocortin	Homo sapiens	132-136
12699442-15	2003	CONCLUSIONS: This study shows that median serum DHEAS levels are significantly lower in GH-deficient patients, even those with intact ACTH reserve, than in aged-matched controls.	Dehydroepiandrosterone Sulfate	48-53	proopiomelanocortin	Homo sapiens	134-138
12534357-0	2003	During a corticotropin-releasing hormone test in healthy subjects, administration of a beta-adrenergic antagonist induced secretion of cortisol and dehydroepiandrosterone sulfate and inhibited secretion of ACTH.	Dehydroepiandrosterone Sulfate	148-178	amyloid beta precursor protein	Homo sapiens	85-91
12727972-5	2003	Steroid hormone production (cortisol, 17-hydroxyprogesterone, and dehydroepiandrosterone sulfate) in NCI-h295 cells was decreased by 1-28-POMC in a concentration-dependent fashion.	Dehydroepiandrosterone Sulfate	66-96	proopiomelanocortin	Homo sapiens	138-142
12523936-6	2003	Furthermore, we found that MRP4 transports dehydroepiandrosterone 3-sulphate (DHEAS), the most abundant circulating steroid in humans, which is made in the adrenal gland.	Dehydroepiandrosterone Sulfate	43-76	ATP binding cassette subfamily C member 4	Homo sapiens	27-31
12523936-6	2003	Furthermore, we found that MRP4 transports dehydroepiandrosterone 3-sulphate (DHEAS), the most abundant circulating steroid in humans, which is made in the adrenal gland.	Dehydroepiandrosterone Sulfate	43-76	sulfotransferase family 2A member 1	Homo sapiens	78-83
12642469-5	2003	On the other hand, expressed CYP3A7-mediated CBZ 10,11-epoxidation was activated by sulfate conjugate steroids, such as pregnenolone 3-sulfate, 17alpha-hydroxypregnenolone 3-sulfate, and dehydroepiandrosterone 3-sulfate (DHEA-S), whereas the unconjugated form corresponding to these three steroids did not activate the reaction.	Dehydroepiandrosterone Sulfate	187-219	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	29-35
12642469-5	2003	On the other hand, expressed CYP3A7-mediated CBZ 10,11-epoxidation was activated by sulfate conjugate steroids, such as pregnenolone 3-sulfate, 17alpha-hydroxypregnenolone 3-sulfate, and dehydroepiandrosterone 3-sulfate (DHEA-S), whereas the unconjugated form corresponding to these three steroids did not activate the reaction.	Dehydroepiandrosterone Sulfate	187-219	sulfotransferase family 2A member 1	Homo sapiens	221-227
12705335-9	2003	Similarly, in hypothyroidism only, dehydroepiandrosterone sulfate correlated positively with immunoglobulin F1 and homocysteine and negatively with thyroid hormones and SHBG.	Dehydroepiandrosterone Sulfate	35-65	sex hormone binding globulin	Homo sapiens	169-173
12629134-4	2003	In Gr1, G/I was significantly higher, and the mean serum IGF-I and serum dehydroepiandrosterone sulfate (DHEAS) were significantly lower than in Gr3 (P &lt; 0.0001).	Dehydroepiandrosterone Sulfate	73-103	sulfotransferase family 2A member 1	Homo sapiens	105-110
12743541-5	2003	E(2) and DHEA-S enhanced AngII effects in both males and females.	Dehydroepiandrosterone Sulfate	9-15	angiotensinogen	Rattus norvegicus	25-30
12488352-7	2003	DHEA-sulfate also reduced the PPARgamma protein, but dexamethasone, testosterone, or androstenedione did not alter its expression.	Dehydroepiandrosterone Sulfate	0-12	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	30-39
12508155-7	2003	There was a significant inverse correlation between DHEA-S and IL-6 plasma levels.	Dehydroepiandrosterone Sulfate	52-58	interleukin 6	Homo sapiens	63-67
14586159-0	2003	Three-month treatment course of methylphenidate increases plasma levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S) in attention deficit hyperactivity disorder.	Dehydroepiandrosterone Sulfate	109-139	sulfotransferase family 2A member 1	Homo sapiens	141-147
12806908-1	2003	DHEA-S (dehydroepiandrosterone sulfate) has many roles in human body as comprehensive vital power, whose metabolite is urine 17-KS-S (abbreviated S), having function of anti-cortisol.	Dehydroepiandrosterone Sulfate	8-38	sulfotransferase family 2A member 1	Homo sapiens	0-6
12621969-1	2003	The aim of this study was to determine relationships between the level of DHEA-sulfate (DHEA-S), an erectile function and libido in men with chronic prostatitis.	Dehydroepiandrosterone Sulfate	74-86	sulfotransferase family 2A member 1	Homo sapiens	88-94
12757651-1	2003	OBJECTIVE: To study the effect of cortisol and dehydroepiandrosterone sulfate (DHEA-S) in fetal umbilical cord blood on term labor.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-85
12363392-1	2002	The authors examined the correlations among plasma levels of ACTH, cortisol, progesterone, testosterone, and dehydroepiandrosterone sulfate (DHEA-S) and their relationship with the scales for assessment of negative symptoms (SANS) in the male schizophrenic patients with negative symptoms.	Dehydroepiandrosterone Sulfate	109-139	sulfotransferase family 2A member 1	Homo sapiens	141-147
12482595-0	2002	In vivo activation of the constitutive androstane receptor beta (CARbeta) by treatment with dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	125-137	syntaxin 8	Homo sapiens	65-72
12630070-10	2002	DHEA-S serum levels were negatively correlated to patient age, sexual function score, total score and PSA.	Dehydroepiandrosterone Sulfate	0-6	kallikrein related peptidase 3	Homo sapiens	102-105
12429044-1	2002	Dehydroepiandrosterone (DHEA) and DHEA sulphate (DHEAS) inhibit T-helper lymphocyte type 2 immune reactions and exert anti-inflammatory effects in some chronic inflammatory diseases.	Dehydroepiandrosterone Sulfate	34-47	sulfotransferase family 2A member 1	Homo sapiens	49-54
12231117-7	2002	Microsomes prepared from LNCaP cultures also showed steryl sulfatase activity, as determined by hydrolysis of [3H]E(1)S and [3H]dehydroepiandrosterone sulfate (DHEAS) to unconjugated forms.	Dehydroepiandrosterone Sulfate	160-165	steroid sulfatase	Homo sapiens	52-68
11956178-5	2002	Pulse-chase experiments with (35)S-labeled 3"-phosphoadenosine 5"-phosphosulfate as a sulfate donor demonstrated that frog NPY (fNPY) inhibited the conversion of [(3)H]Delta(5)P and [(3)H]dehydroepiandrosterone ([(3)H]DHEA) into [(3)H,(35)S]Delta(5)PS and [(3)H,(35)S]DHEAS by diencephalic explants.	Dehydroepiandrosterone Sulfate	268-273	neuropeptide Y	Homo sapiens	123-126
12102568-0	2002	Effects of ketamine-xylazine and isoflurane on insulin sensitivity in dehydroepiandrosterone sulfate-treated minipigs (Sus scrofa domestica).	Dehydroepiandrosterone Sulfate	70-100	insulin	Sus scrofa	47-54
12102568-3	2002	The steroid hormones, dehydroepiandrosterone (DHEA) and its sulfated form, dehydroepiandrosterone-sulfate (DHEAS), have variable effects on insulin sensitivity in animals.	Dehydroepiandrosterone Sulfate	75-105	insulin	Sus scrofa	140-147
12102568-3	2002	The steroid hormones, dehydroepiandrosterone (DHEA) and its sulfated form, dehydroepiandrosterone-sulfate (DHEAS), have variable effects on insulin sensitivity in animals.	Dehydroepiandrosterone Sulfate	107-112	insulin	Sus scrofa	140-147
12102568-9	2002	During KX anesthesia, mean insulin concentration in DHEAS-treated and control groups approximated half the postisoflurane values (P &lt; 0.001).	Dehydroepiandrosterone Sulfate	52-57	insulin	Sus scrofa	27-34
12102568-10	2002	While under isoflurane, the DHEAS group had significantly higher mean plasma insulin concentration and mean insulin-to-glucose ratio, compared with values for controls (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	28-33	insulin	Sus scrofa	77-84
12102568-10	2002	While under isoflurane, the DHEAS group had significantly higher mean plasma insulin concentration and mean insulin-to-glucose ratio, compared with values for controls (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	28-33	insulin	Sus scrofa	108-115
12102568-11	2002	These findings are consistent with changes in insulin values following DHEAS treatment observed previously in nonanesthetized swine.	Dehydroepiandrosterone Sulfate	71-76	insulin	Sus scrofa	46-53
12102568-13	2002	These results suggest that KX significantly decreases plasma insulin concentration and blunts DHEAS-associated insulin resistance in female minipigs.	Dehydroepiandrosterone Sulfate	94-99	insulin	Sus scrofa	111-118
12073659-2	2002	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEA)--the major androgen products of the adrenal gland--have immunosuppressive effect inhibiting interleukin-6 production and substantially determining acute phase reaction.	Dehydroepiandrosterone Sulfate	34-65	interleukin 6	Homo sapiens	165-178
11950789-5	2002	In wild-type mice, 150 mg/kg DHEA-sulfate induced Cyp4a and Cyp3a11 mRNAs by 5- and 2-fold, respectively.	Dehydroepiandrosterone Sulfate	29-41	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	50-55
11950789-5	2002	In wild-type mice, 150 mg/kg DHEA-sulfate induced Cyp4a and Cyp3a11 mRNAs by 5- and 2-fold, respectively.	Dehydroepiandrosterone Sulfate	29-41	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	60-67
11950789-6	2002	Induction of Cyp4a expression by DHEA-sulfate was not observed in PPAR(alpha)-null mice, whereas induction of Cyp3a11 expression by DHEA-sulfate was similar between genotypes.	Dehydroepiandrosterone Sulfate	33-45	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	13-18
11950789-6	2002	Induction of Cyp4a expression by DHEA-sulfate was not observed in PPAR(alpha)-null mice, whereas induction of Cyp3a11 expression by DHEA-sulfate was similar between genotypes.	Dehydroepiandrosterone Sulfate	132-144	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	110-117
11956178-1	2002	We have recently shown that hydroxysteroid sulfotransferase (HST), the enzyme responsible for the biosynthesis of pregnenolone sulfate (Delta(5)PS) and dehydroepiandrosterone sulfate (DHEAS), is expressed in neurons located in the anterior preoptic area and the dorsal magnocellular nucleus of the frog diencephalon.	Dehydroepiandrosterone Sulfate	152-182	sulfotransferase family 2A member 1	Homo sapiens	61-64
11956178-1	2002	We have recently shown that hydroxysteroid sulfotransferase (HST), the enzyme responsible for the biosynthesis of pregnenolone sulfate (Delta(5)PS) and dehydroepiandrosterone sulfate (DHEAS), is expressed in neurons located in the anterior preoptic area and the dorsal magnocellular nucleus of the frog diencephalon.	Dehydroepiandrosterone Sulfate	184-189	sulfotransferase family 2A member 1	Homo sapiens	61-64
12425955-7	2002	With regard to the HPA function, the most significant decline was found in dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulphate (DHEAS).	Dehydroepiandrosterone Sulfate	109-140	sulfotransferase family 2A member 1	Homo sapiens	142-147
12101011-4	2002	Functional expression in Xenopus laevis oocytes demonstrated that mouse Oatp2 transports several general Oatp substrates such as estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS), ouabain and BQ-123 but hardly any taurocholate nor rocuronium or deltorphin II.	Dehydroepiandrosterone Sulfate	148-178	solute carrier organic anion transporter family, member 1a4	Mus musculus	72-77
12101011-4	2002	Functional expression in Xenopus laevis oocytes demonstrated that mouse Oatp2 transports several general Oatp substrates such as estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS), ouabain and BQ-123 but hardly any taurocholate nor rocuronium or deltorphin II.	Dehydroepiandrosterone Sulfate	148-178	solute carrier organic anion transporter family, member 1a6	Mus musculus	72-76
12101011-4	2002	Functional expression in Xenopus laevis oocytes demonstrated that mouse Oatp2 transports several general Oatp substrates such as estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS), ouabain and BQ-123 but hardly any taurocholate nor rocuronium or deltorphin II.	Dehydroepiandrosterone Sulfate	180-185	solute carrier organic anion transporter family, member 1a4	Mus musculus	72-77
12101011-4	2002	Functional expression in Xenopus laevis oocytes demonstrated that mouse Oatp2 transports several general Oatp substrates such as estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS), ouabain and BQ-123 but hardly any taurocholate nor rocuronium or deltorphin II.	Dehydroepiandrosterone Sulfate	180-185	solute carrier organic anion transporter family, member 1a6	Mus musculus	72-76
12161487-3	2002	In the population-based Rotterdam Study, we investigated the association of levels of dehydroepiandrosterone sulfate (DHEAS) and total and bioavailable testosterone with aortic atherosclerosis among 1,032 nonsmoking men and women aged 55 yr and over.	Dehydroepiandrosterone Sulfate	86-116	sulfotransferase family 2A member 1	Homo sapiens	118-123
12161507-1	2002	In this report, 3029 women between the ages of 42 and 54 yr from five ethnic groups were studied for 2 yr. Log circulating dehydroepiandrosterone sulfate (DHEAS) concentrations were highest among Chinese and Japanese and lowest among African Americans and Hispanics, and this pattern persisted after adjustment for age, smoking, and log body mass index (BMI).	Dehydroepiandrosterone Sulfate	123-153	sulfotransferase family 2A member 1	Homo sapiens	155-160
11909687-1	2002	The association of low serum dehydroepiandrosterone sulfate (DHEAS) levels with age, lifestyle, general health status indicators, and specific diseases was investigated in 436 men and 544 women of 65-97 yr old.	Dehydroepiandrosterone Sulfate	29-59	sulfotransferase family 2A member 1	Homo sapiens	61-66
11994353-7	2002	Brothers of women with PCOS had significantly elevated dehydroepiandrosterone sulfate (DHEAS) levels [brothers 3035 +/- 1132 ng/ml (mean +/- SD) vs. control men 2494 +/- 1172 ng/ml; P &lt; 0.05].	Dehydroepiandrosterone Sulfate	55-85	sulfotransferase family 2A member 1	Homo sapiens	87-92
12044959-2	2002	On the other hand, the plasma dehydroepiandrosterone sulfate (DHEA-S) changes remarkably during aging.	Dehydroepiandrosterone Sulfate	30-60	sulfotransferase family 2A member 1	Homo sapiens	62-68
12044960-1	2002	A significant positive correlation between bone mineral density (BMD) and serum dehydroepiandrosterone sulfate (DHEA-S) was found in 120 postmenopausal women (51-99 years old) but no correlation was seen between BMD and serum estradiol.	Dehydroepiandrosterone Sulfate	80-110	sulfotransferase family 2A member 1	Homo sapiens	112-118
12007898-2	2002	DESIGN: A review of current literature on sexual function and the androgen precursor hormone dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	127-157	sulfotransferase family 2A member 1	Homo sapiens	159-164
11888843-7	2002	A multiple linear regression analysis revealed that elevated serum levels of TNF were associated with a high ratio of serum levels of DHEA/ASD in all groups (for IL-6 in patients with an acute inflammatory stressful disease state only), and, similarly, elevated serum levels of TNF were associated with a high ratio of serum levels of DHEAS/DHEA only in IBD (for IL-6 only in healthy subjects).	Dehydroepiandrosterone Sulfate	335-340	tumor necrosis factor	Homo sapiens	77-80
11912073-4	2002	ACTH and prolactin correlated positively with cortisol, DHEAS and testosterone in women, which suggests that prolactin and ACTH could contribute to stimulated adrenal androgen production.	Dehydroepiandrosterone Sulfate	56-61	proopiomelanocortin	Homo sapiens	0-4
11912073-4	2002	ACTH and prolactin correlated positively with cortisol, DHEAS and testosterone in women, which suggests that prolactin and ACTH could contribute to stimulated adrenal androgen production.	Dehydroepiandrosterone Sulfate	56-61	prolactin	Homo sapiens	9-18
11912073-4	2002	ACTH and prolactin correlated positively with cortisol, DHEAS and testosterone in women, which suggests that prolactin and ACTH could contribute to stimulated adrenal androgen production.	Dehydroepiandrosterone Sulfate	56-61	prolactin	Homo sapiens	109-118
11912073-4	2002	ACTH and prolactin correlated positively with cortisol, DHEAS and testosterone in women, which suggests that prolactin and ACTH could contribute to stimulated adrenal androgen production.	Dehydroepiandrosterone Sulfate	56-61	proopiomelanocortin	Homo sapiens	123-127
11940375-1	2002	OBJECTIVE: To study the effect of dehydroepiandrosterone sulfate (DHEAS) treatment of osteoporosis in men with T(BMD) &gt; or = 2.5SD.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
12008748-1	2002	The current study aimed to investigate the midterm (24 hour) response of 17-hydroxyprogesterone (17-OHP) and dehydroepiandrosterone sulphate (DHEA-S) to synthetic high-dose adrenocorticotropin (ACTH) in adrenal incidentalomas (Al).	Dehydroepiandrosterone Sulfate	109-140	sulfotransferase family 2A member 1	Homo sapiens	142-148
11972301-3	2002	Using the PCR technique, the polymorphic FokI, ApaI, TaqI and BsmI sites of the VDR gene were determined in relation to serum dehydroepiandrosterone sulphate (DHEAS), androstenedione (AD), testosterone, and estradiol levels.	Dehydroepiandrosterone Sulfate	126-157	vitamin D receptor	Homo sapiens	80-83
12014422-1	2002	BACKGROUND AND AIMS: We investigated the coexistence of dehydroepiandrosterone sulfate (DHEAS) and testosterone deficiency in men with inflammatory bowel disease (IBD) and their relationship with bone homeostasis.	Dehydroepiandrosterone Sulfate	56-86	sulfotransferase family 2A member 1	Homo sapiens	88-93
11748225-7	2002	In contrast, basal-to-apical transport of estrone-3-sulfate and dehydroepiandrosterone sulfate, which are significantly transported by OATP2, but not by MRP2, was not stimulated by MRP2 expression.	Dehydroepiandrosterone Sulfate	64-94	solute carrier organic anion transporter family member 1B1	Homo sapiens	135-140
12008748-1	2002	The current study aimed to investigate the midterm (24 hour) response of 17-hydroxyprogesterone (17-OHP) and dehydroepiandrosterone sulphate (DHEA-S) to synthetic high-dose adrenocorticotropin (ACTH) in adrenal incidentalomas (Al).	Dehydroepiandrosterone Sulfate	109-140	proopiomelanocortin	Homo sapiens	194-198
11834296-0	2002	Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signaling pathway in opposing ways.	Dehydroepiandrosterone Sulfate	59-64	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
11836304-0	2002	Genetics of serum dehydroepiandrosterone sulfate and its relationship to insulin in a population-based cohort of twin subjects.	Dehydroepiandrosterone Sulfate	18-48	insulin	Homo sapiens	73-80
11836304-1	2002	Previous studies have shown a significant effect of insulin administration on serum dehydroepiandrosterone sulfate (DHEA-S) concentration and its metabolic rate, with evidence for the effect in men, but not in women.	Dehydroepiandrosterone Sulfate	84-114	insulin	Homo sapiens	52-59
11836304-1	2002	Previous studies have shown a significant effect of insulin administration on serum dehydroepiandrosterone sulfate (DHEA-S) concentration and its metabolic rate, with evidence for the effect in men, but not in women.	Dehydroepiandrosterone Sulfate	84-114	sulfotransferase family 2A member 1	Homo sapiens	116-122
12053088-1	2002	BACKGROUND: The present study aimed to determine whether decreases in dehydroepiandrosterone sulfate (DHEA-S) and growth axis components precede cardiovascular disease or are a consequence of it.	Dehydroepiandrosterone Sulfate	70-100	sulfotransferase family 2A member 1	Homo sapiens	102-108
11834296-2	2002	We cultured neural precursors from the embryonic forebrain of rats and examined the effects of DHEA and its sulfated derivative (DHEAS) on the activation of the serine-threonine protein kinase Akt, which is widely implicated in cell survival signaling.	Dehydroepiandrosterone Sulfate	129-134	AKT serine/threonine kinase 1	Rattus norvegicus	193-196
11834296-4	2002	In contrast, DHEAS decreased activated Akt levels and increased apoptosis.	Dehydroepiandrosterone Sulfate	13-18	AKT serine/threonine kinase 1	Rattus norvegicus	39-42
11898695-0	2002	Decreased free testosterone and dehydroepiandrosterone-sulfate (DHEA-S) levels in women with decreased libido.	Dehydroepiandrosterone Sulfate	32-62	sulfotransferase family 2A member 1	Homo sapiens	64-70
11898695-5	2002	On subsequent testing, 74 of the women (70%) were found to have decreased total testosterone, free testosterone, and dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	117-147	sulfotransferase family 2A member 1	Homo sapiens	149-155
11750771-1	2002	Changes in plasma levels of cortisol and dehydroepiandrosterone sulfate (DHEA-S) following cocaine discontinuation were assessed in hospitalized chronic cocaine users.	Dehydroepiandrosterone Sulfate	41-71	sulfotransferase family 2A member 1	Homo sapiens	73-79
12387582-0	2002	Diurnal rhythm and effects of oral contraceptives on serum dehydroepiandrosterone sulfate (DHEAS) are related to alterations in serum albumin rather than to changes in adrenocortical steroid secretion.	Dehydroepiandrosterone Sulfate	59-89	albumin	Homo sapiens	128-141
12387582-0	2002	Diurnal rhythm and effects of oral contraceptives on serum dehydroepiandrosterone sulfate (DHEAS) are related to alterations in serum albumin rather than to changes in adrenocortical steroid secretion.	Dehydroepiandrosterone Sulfate	91-96	albumin	Homo sapiens	128-141
12387582-4	2002	DHEAS is strongly bound to serum albumin and has a very low metabolic clearance rate.	Dehydroepiandrosterone Sulfate	0-5	albumin	Homo sapiens	27-40
12387582-11	2002	Changes in serum DHEAS during the day and following OC use are related to alterations in its main binding protein, serum albumin, rather than to changes in adrenocortical steroid secretion.	Dehydroepiandrosterone Sulfate	17-22	albumin	Homo sapiens	115-128
11743952-1	2001	The steroid sulfatase enzyme (STS) regulates the formation of dehydroepiandrosterone (DHEA) from dehydroepiandrosterone-sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	97-127	steroid sulfatase	Mus musculus	4-28
11743952-1	2001	The steroid sulfatase enzyme (STS) regulates the formation of dehydroepiandrosterone (DHEA) from dehydroepiandrosterone-sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	129-134	steroid sulfatase	Mus musculus	4-28
11711114-3	2001	11 alpha-Hemiglutaryloxy-DHEAS was newly synthesized, conjugated with bovine serum albumin (BSA), and immunized to rabbits for the production of anti-DHEAS antibodies.	Dehydroepiandrosterone Sulfate	25-30	albumin	Rattus norvegicus	77-90
11753757-3	2001	It has previously been shown that sulfated steroids, such as estrone sulfate and dehydroepiandrosterone sulfate, inhibit the glucose-6-phosphatase system in vitro, principally through inhibition of endoplasmic reticulum glucose-6-phosphate transport.	Dehydroepiandrosterone Sulfate	81-111	glucose-6-phosphatase, catalytic	Mus musculus	125-146
11742322-3	2001	METHODS: Patients who underwent oophorectomy and were being treated with new aromatase inhibitor therapy received serial measurements of serum estrone, estradiol, and DHEA-sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	167-179	sulfotransferase family 2A member 1	Homo sapiens	181-187
11711057-4	2001	Dehydroepiandrosterone sulfate treatment significantly increased the [3H]MK801 binding sites in hippocampal areas (field CA1, CA3, dentate gyrus lateral blade and medial blade) and in cortex layer IV as compared to the control group.	Dehydroepiandrosterone Sulfate	0-30	carbonic anhydrase 1	Rattus norvegicus	121-124
11699050-1	2001	A genome-wide linkage scan was performed to identify genomic regions that influence levels of dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), and DHEA fatty acid esters (DHEA-FA) at baseline and in response to 20 weeks of endurance exercise training in sedentary white and black participants in the HERITAGE Family Study.	Dehydroepiandrosterone Sulfate	125-137	sulfotransferase family 2A member 1	Homo sapiens	139-144
11713643-5	2001	Similar to Oatp1 and Oatp2, Oatp4 is a multispecific transporter with high affinities for bromosulfophthalein, dehydroepiandrosterone sulfate, leukotriene C4, and anionic peptides.	Dehydroepiandrosterone Sulfate	111-141	solute carrier organic anion transporter family, member 1a1	Rattus norvegicus	11-16
11713643-5	2001	Similar to Oatp1 and Oatp2, Oatp4 is a multispecific transporter with high affinities for bromosulfophthalein, dehydroepiandrosterone sulfate, leukotriene C4, and anionic peptides.	Dehydroepiandrosterone Sulfate	111-141	solute carrier organic anion transporter family, member 1a4	Rattus norvegicus	21-26
11713643-5	2001	Similar to Oatp1 and Oatp2, Oatp4 is a multispecific transporter with high affinities for bromosulfophthalein, dehydroepiandrosterone sulfate, leukotriene C4, and anionic peptides.	Dehydroepiandrosterone Sulfate	111-141	solute carrier organic anion transporter family member 1B2	Rattus norvegicus	28-33
11591406-10	2001	RESULT(S): Analysis of the combined data from all donors indicated that insulin stimulated DHEAS and suppressed DHEA production but had no consistent effect on F. Similar analyses of the combined data indicated that T had no significant predictable effect on the production of DHEAS, DHEA, or F. When examining donor data individually, insulin and T did elicit significant increases and/or decreases in steroid production within subjects, although no consistent trends were observed.	Dehydroepiandrosterone Sulfate	91-96	insulin	Homo sapiens	72-79
11591406-12	2001	In general, insulin stimulated DHEAS and decreased DHEA production, suggesting that it increases adrenocortical sulfotransferase activity.	Dehydroepiandrosterone Sulfate	31-36	insulin	Homo sapiens	12-19
11591406-13	2001	However, although in the individual subjects studied, both insulin and T frequently altered the production of DHEAS, DHEA or F, these effects did not appear to be uniform or consistent from subject to subject.	Dehydroepiandrosterone Sulfate	110-115	insulin	Homo sapiens	59-66
11853283-1	2001	The most abundant human steroid, dehydroepiandrosterone sulfate (DHEAS), may have a multitude of beneficial effects, but declines with age.	Dehydroepiandrosterone Sulfate	33-63	sulfotransferase family 2A member 1	Homo sapiens	65-70
11589675-1	2001	OBJECTIVE: Plasma levels of dehydroepiandrosterone sulphate (DHEA-S) decrease with the progression of HIV disease.	Dehydroepiandrosterone Sulfate	28-59	sulfotransferase family 2A member 1	Homo sapiens	61-67
11549701-2	2001	There is a functional interaction between CRH and the fetal adrenal, as CRH increases dehydroepiandrosterone sulfate production in cultured fetal adrenal cells.	Dehydroepiandrosterone Sulfate	86-116	corticotropin releasing hormone	Homo sapiens	42-45
11549701-2	2001	There is a functional interaction between CRH and the fetal adrenal, as CRH increases dehydroepiandrosterone sulfate production in cultured fetal adrenal cells.	Dehydroepiandrosterone Sulfate	86-116	corticotropin releasing hormone	Homo sapiens	72-75
11592593-7	2001	Levels of ACTH and DHEAS in relation to serum IL-6 or TNF were higher in Co as compared to the cholestatic subgroup without tumours, whereas serum cortisol in relation to these cytokines was similar.	Dehydroepiandrosterone Sulfate	19-24	interleukin 6	Homo sapiens	46-50
11592593-7	2001	Levels of ACTH and DHEAS in relation to serum IL-6 or TNF were higher in Co as compared to the cholestatic subgroup without tumours, whereas serum cortisol in relation to these cytokines was similar.	Dehydroepiandrosterone Sulfate	19-24	tumor necrosis factor	Homo sapiens	54-57
11704078-1	2001	BACKGROUND: The objective of this study was to elucidate the associations of dehydroepiandrosterone sulfate (DHEA-S) levels and depressive symptoms in African American and Caucasian women in the late reproductive years, a transitional age zone preceding the perimenopause, in which ovarian aging and associated endocrine changes begin.	Dehydroepiandrosterone Sulfate	77-107	sulfotransferase family 2A member 1	Homo sapiens	109-115
11747281-0	2001	Low basal androstenedione levels plus augmented 17alpha-hydroxyprogesterone and low dehydroepiandrosterone sulfate responses to adrenocorticotropic hormone stimulation in patients with adrenal incidentaloma.	Dehydroepiandrosterone Sulfate	84-114	proopiomelanocortin	Homo sapiens	128-155
11747281-1	2001	OBJECTIVE: To investigate the androstenedione, 17a-hydroxyprogesterone (17-OHP), and dehydroepiandrosterone sulfate (DHEAS) basal levels and responses to adrenocorticotropic hormone (ACTH) in patients with adrenal incidentalomas in order to determine which enzyme defects are present.	Dehydroepiandrosterone Sulfate	85-115	sulfotransferase family 2A member 1	Homo sapiens	117-122
11738554-1	2001	Estrone (E1)/dehydroepiandrosterone (DHEA) sulfatase (ES/DHEAS) catalyzes the hydrolysis of E1 and DHEA-sulfates releasing unconjugated steroids.	Dehydroepiandrosterone Sulfate	99-112	small nucleolar RNA, H/ACA box 73A	Homo sapiens	9-52
11797418-3	2001	DHEAS attenuated the conditioned fear stress response in mice, the effects being antagonized by a sigma 1 receptor antagonist.	Dehydroepiandrosterone Sulfate	0-5	sigma non-opioid intracellular receptor 1	Mus musculus	98-114
11711057-4	2001	Dehydroepiandrosterone sulfate treatment significantly increased the [3H]MK801 binding sites in hippocampal areas (field CA1, CA3, dentate gyrus lateral blade and medial blade) and in cortex layer IV as compared to the control group.	Dehydroepiandrosterone Sulfate	0-30	carbonic anhydrase 3	Rattus norvegicus	126-129
11678578-5	2001	We found that plasma levels of free testosterone, dehydroepiandrosterone sulfate (DHEAS) and estradiol significantly higher in the women with POS group than in the healthy women group.	Dehydroepiandrosterone Sulfate	50-80	sulfotransferase family 2A member 1	Homo sapiens	82-87
11569618-7	2001	High correlations were observed between hepatic levels of DHEA or DHEAS and stearoyl-CoA desaturase activities in rats.	Dehydroepiandrosterone Sulfate	66-71	stearoyl-CoA desaturase	Rattus norvegicus	76-99
11585284-1	2001	In 1994 the Massachusetts Male Aging Study described an inverse correlation of the serum levels of dehydroepiandrosterone sulfate (DHEAS) and the incidence of erectile dysfunction (ED).	Dehydroepiandrosterone Sulfate	99-129	sulfotransferase family 2A member 1	Homo sapiens	131-136
11451621-1	2001	OBJECTIVE: To demonstrate that hypoestrogenism in menopause is in part responsible for the decrease in circulating dehydroepiandrosterone sulfate (DHEA-S) and ACTH levels.	Dehydroepiandrosterone Sulfate	115-145	sulfotransferase family 2A member 1	Homo sapiens	147-153
11299059-3	2001	The present study was designed to evaluate the secretion of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) and its relation to clinical variables in RA, spondyloarthropathy (Spa), and undifferentiated inflammatory arthritis (UIA).	Dehydroepiandrosterone Sulfate	81-111	sulfotransferase family 2A member 1	Homo sapiens	113-118
11314741-0	2001	Relationships between cortisol, dehydroepiandrosterone sulphate and insulin-like growth factor-I system in dementia.	Dehydroepiandrosterone Sulfate	32-63	insulin like growth factor 1	Homo sapiens	68-96
11314741-10	2001	IGFBP-3 correlated directly with DHEAS.	Dehydroepiandrosterone Sulfate	33-38	insulin like growth factor binding protein 3	Homo sapiens	0-7
11408725-0	2001	Plasma insulin-like growth factor I levels in the elderly: relation to plasma dehydroepiandrosterone sulfate levels, nutritional status, health and mortality.	Dehydroepiandrosterone Sulfate	78-108	insulin like growth factor 1	Homo sapiens	7-35
11408725-2	2001	Because plasma IGF-I levels have been reported to be enhanced by dehydroepiandrosterone (DHEA) administration, it has been suggested that the IGF-I may be implicated in some of the reported associations between low DHEA sulfate (DHEAS) levels and impaired health measures in elderly subjects.	Dehydroepiandrosterone Sulfate	215-227	insulin like growth factor 1	Homo sapiens	142-147
11434664-4	2001	There was a negative correlation between age and dehydroepiandrosterone sulphate (DHEAS) (r=-0.60, p=0.022) and a positive correlation between GH and IGF-I (r=0.53, p=0.048).	Dehydroepiandrosterone Sulfate	49-80	sulfotransferase family 2A member 1	Homo sapiens	82-87
11344212-9	2001	In addition, fibronectin enhanced dehydroepiandrosterone sulfate but decreased cortisol secretion, compared with collagen IV substrates.	Dehydroepiandrosterone Sulfate	34-64	fibronectin 1	Homo sapiens	13-24
11306713-6	2001	hOAT3 also mediated the transport of dehydroepiandrosterone sulfate, ochratoxin A, PGE(2), estradiol glucuronide, taurocholate, glutarate, cAMP and uric acid.	Dehydroepiandrosterone Sulfate	37-67	solute carrier family 22 member 8	Homo sapiens	0-5
11267661-4	2001	In addition to the previously reported estrone-3-sulfate, we demonstrate that mouse Oatp1 mediates sodium-independent uptake of the anionic steroid conjugates dehydroepiandrosterone sulfate (K(m) approximately 8 microM) and estradiol-17-glucuronide (K(m) approximately 5 microM) and also of the prostaglandin PGE(2).	Dehydroepiandrosterone Sulfate	159-189	solute carrier organic anion transporter family, member 1a1	Mus musculus	84-89
11241888-3	2001	A unifying hypothesis explaining the relationship between aging and insulin resistance might encompass four main pathways, namely: (a) anthropometric changes (relative and absolute increase in body fat combined with a decline in fat free mass) which could be the anatomic substrate for explaining the reduction in active metabolic tissue; (b) environmental causes, mainly diet style and physical activity; (c) neuro-hormonal variations [decline in plasma dehydroepandrosterone sulphate (DHEAS) and IGF-1]; and finally (d) the rise in oxidative stress.	Dehydroepiandrosterone Sulfate	487-492	insulin	Homo sapiens	68-75
11247320-1	2001	OBJECTIVE: To evaluate in a cohort of women with systemic sclerosis (SSc) the dehydroepiandrosterone sulphate (DHEAS) serum levels and their relationship with disease severity.	Dehydroepiandrosterone Sulfate	78-109	sulfotransferase family 2A member 1	Homo sapiens	111-116
11815723-1	2001	OBJECTIVE: To assess biochemical characteristics of adrenarche in patients with myelomeningocele (MMC), we examined serum levels of dehydroepiandrosterone sulfate (DHEAS) in prepubertal MMC patients.	Dehydroepiandrosterone Sulfate	132-162	sulfotransferase family 2A member 1	Homo sapiens	164-169
11847477-9	2001	On the combination of 15 mg/m2 DHEAS and full estrogen substitution, IGF-I SDS increased to an average of -0.15.	Dehydroepiandrosterone Sulfate	31-36	insulin like growth factor 1	Homo sapiens	69-74
11403266-2	2001	The concentration of 17beta-estradiol (E2), progesterone (Pg) and dehydroepiandrosterone-sulphate (DHEAS) was monitored in sera from 128 lupus patients and 96 controls, and correlated with the activity of their cytokine secreting cells.	Dehydroepiandrosterone Sulfate	66-97	sulfotransferase family 2A member 1	Homo sapiens	99-104
11134123-1	2000	Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are adrenal precursors of steroid biosynthesis and centrally acting neurosteroids.	Dehydroepiandrosterone Sulfate	34-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
11134118-1	2000	Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) have immunomodulatory effects in vitro and in vivo.	Dehydroepiandrosterone Sulfate	34-46	sulfotransferase family 2A member 1	Homo sapiens	48-54
11115773-1	2000	Dehydroepiandrosterone sulphate (DHEAS) is the most abundant androgen in the circulation and in ovarian follicular fluid.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-38
11145117-3	2000	We examined the cross-sectional relationships of serum concentrations of estradiol (E2) and DHEA sulfate (DHEAS) and dietary intake of soy products to psychologic status measured using the Center for Epidemiologic Studies Depression Scale (CES-D) and General Health Questionnaire (GHQ)-12 scales in 86 peri- and postmenopausal Japanese women.	Dehydroepiandrosterone Sulfate	92-104	sulfotransferase family 2A member 1	Homo sapiens	106-111
11106916-3	2000	The aim of this study was to determine the effects of DHEA replacement on bone mineral density (BMD) and body composition in elderly women and men with low serum DHEA sulphate (DHEAS) levels.	Dehydroepiandrosterone Sulfate	162-175	sulfotransferase family 2A member 1	Homo sapiens	177-182
11032880-0	2000	Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2.	Dehydroepiandrosterone Sulfate	82-112	solute carrier organic anion transporter family, member 1a4	Mus musculus	118-158
11032880-6	2000	In cellular uptake studies using a conditionally immortalized mouse brain capillary endothelial cell line (TM-BBB4), [(3)H]DHEAS uptake by TM-BBB4 cells exhibited a concentration dependence with a K:(m) of 34.4 microM: and was significantly inhibited by the oatp2-specific substrate digoxin.	Dehydroepiandrosterone Sulfate	123-128	solute carrier organic anion transporter family, member 1a4	Mus musculus	258-263
11032880-10	2000	In conclusion, DHEAS efflux transport takes place across the BBB, and studies involving in vitro DHEAS uptake and RT-PCR suggest that there is oatp2-mediated DHEAS transport at the BBB.	Dehydroepiandrosterone Sulfate	15-20	solute carrier organic anion transporter family, member 1a4	Mus musculus	143-148
11032880-10	2000	In conclusion, DHEAS efflux transport takes place across the BBB, and studies involving in vitro DHEAS uptake and RT-PCR suggest that there is oatp2-mediated DHEAS transport at the BBB.	Dehydroepiandrosterone Sulfate	97-102	solute carrier organic anion transporter family, member 1a4	Mus musculus	143-148
11032880-10	2000	In conclusion, DHEAS efflux transport takes place across the BBB, and studies involving in vitro DHEAS uptake and RT-PCR suggest that there is oatp2-mediated DHEAS transport at the BBB.	Dehydroepiandrosterone Sulfate	97-102	solute carrier organic anion transporter family, member 1a4	Mus musculus	143-148
11004724-8	2000	Levels of urinary 17-ketosteroids and plasma dehydroepiandrosterone sulfate (DHEA-S), which are abnormal in approximately 90% of the cases, provide the pivotal clue to a diagnosis of ACT.	Dehydroepiandrosterone Sulfate	45-75	sulfotransferase family 2A member 1	Homo sapiens	77-83
11045794-9	2000	Statistically significant trends in the relationship between alcohol consumption and hormone level dependent on oxidative capacity (ADH3 genotype) were observed for dehydroepiandrosterone sulfate and sex hormone-binding globulin (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	165-195	alcohol dehydrogenase 1C (class I), gamma polypeptide	Homo sapiens	132-136
11168823-1	2000	Cross-sectional studies of humans have shown that dehydroepiandrosterone sulfate (DHEAS) peaks shortly after sexual maturation and declines thereafter, suggesting that the progressive reduction in DHEAS may play a role in the aging process and in the development of age-related morbidity.	Dehydroepiandrosterone Sulfate	50-80	sulfotransferase family 2A member 1	Homo sapiens	82-87
11168823-1	2000	Cross-sectional studies of humans have shown that dehydroepiandrosterone sulfate (DHEAS) peaks shortly after sexual maturation and declines thereafter, suggesting that the progressive reduction in DHEAS may play a role in the aging process and in the development of age-related morbidity.	Dehydroepiandrosterone Sulfate	50-80	sulfotransferase family 2A member 1	Homo sapiens	197-202
10815698-1	2000	This purpose of this study was to evaluate whether serum dehydroepiandrosterone (DHEA) and its sulfate conjugate, dehydroepiandrosterone sulfate (DHEAS), are associated with the likelihood of developing colon cancer.	Dehydroepiandrosterone Sulfate	114-144	sulfotransferase family 2A member 1	Homo sapiens	146-151
11022133-1	2000	Neuroactive steroids such as dehydroepiandrosterone sulfate and pregnenolone inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production.	Dehydroepiandrosterone Sulfate	29-59	tumor necrosis factor	Mus musculus	118-139
11022133-1	2000	Neuroactive steroids such as dehydroepiandrosterone sulfate and pregnenolone inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production.	Dehydroepiandrosterone Sulfate	29-59	tumor necrosis factor	Mus musculus	141-144
10942851-2	2000	This conditioned fear stress response was dose-dependently attenuated by neurosteroids such as dehydroepiandrosterone sulfate (DHEAS; 25 and 50 mg/kg, s.c.) and pregnenolone sulfate (PREGS; 10-50 mg/kg, s.c.), and by a putative sigma(1) receptor agonist, (+)-N-allylnormetazocine ((+)-SKF-10,047; 3 and 6 mg/kg, s.c.).	Dehydroepiandrosterone Sulfate	95-125	sigma non-opioid intracellular receptor 1	Mus musculus	228-245
10964263-2	2000	Although DHEA and DHEA sulfate (DHEAS) are secreted in relatively high quantities by the human adrenal, the laboratory rat secretes very little, thus hindering experimental studies of the hormone.	Dehydroepiandrosterone Sulfate	18-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
11082899-1	2000	OBJECTIVES: The serum concentration of dehydroepiandrosterone sulfate (DHEAS) in relation to serum levels of follicle stimulating hormone, estradiol, insulin-like growth factor I (IGF-I) and height and weight velocity in girls during puberty were studied.	Dehydroepiandrosterone Sulfate	39-69	sulfotransferase family 2A member 1	Homo sapiens	71-76
11082899-1	2000	OBJECTIVES: The serum concentration of dehydroepiandrosterone sulfate (DHEAS) in relation to serum levels of follicle stimulating hormone, estradiol, insulin-like growth factor I (IGF-I) and height and weight velocity in girls during puberty were studied.	Dehydroepiandrosterone Sulfate	39-69	insulin like growth factor 1	Homo sapiens	150-178
11082899-1	2000	OBJECTIVES: The serum concentration of dehydroepiandrosterone sulfate (DHEAS) in relation to serum levels of follicle stimulating hormone, estradiol, insulin-like growth factor I (IGF-I) and height and weight velocity in girls during puberty were studied.	Dehydroepiandrosterone Sulfate	39-69	insulin like growth factor 1	Homo sapiens	180-185
10904463-3	2000	OBJECTIVE: To investigate the relationship between age-associated decreases in endogenous DHEA sulfate (DHEA-S) concentrations and declines in neuropsychological performance in a prospective, longitudinal study.	Dehydroepiandrosterone Sulfate	90-102	sulfotransferase family 2A member 1	Homo sapiens	104-110
10854906-6	2000	The beneficial effects of SA4503, DHEAS and PREGS were antagonized by treatment with sigma(1) receptor antagonist N, N-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)-ethylamine hydrochloride (NE-100).	Dehydroepiandrosterone Sulfate	34-39	sigma non-opioid intracellular receptor 1	Rattus norvegicus	85-102
10854906-9	2000	Furthermore, it is suggested that DHEAS and PREGS ameliorate dizocilpine-induced memory impairments by acting as sigma(1) receptor agonists, while PROG antagonizes their effects by acting as a sigma(1) receptor antagonist.	Dehydroepiandrosterone Sulfate	34-39	sigma non-opioid intracellular receptor 1	Rattus norvegicus	113-130
10929062-1	2000	This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo.	Dehydroepiandrosterone Sulfate	87-118	sulfotransferase family 2A member 1	Homo sapiens	120-126
10929062-1	2000	This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo.	Dehydroepiandrosterone Sulfate	87-118	interleukin 6	Homo sapiens	220-224
10929062-1	2000	This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo.	Dehydroepiandrosterone Sulfate	87-118	interleukin 10	Homo sapiens	226-231
10929062-1	2000	This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo.	Dehydroepiandrosterone Sulfate	87-118	tumor necrosis factor	Homo sapiens	263-272
10929062-1	2000	This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo.	Dehydroepiandrosterone Sulfate	87-118	interferon gamma	Homo sapiens	277-293
10929062-1	2000	This work examines the correlation between serum levels of oestrogen, progesterone and dehydroepiandrosterone sulphate (DHEA-S) and the number of human peripheral blood cells actively secreting interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor-alpha (TNF-alpha) or interferon-gamma (IFN-gamma) in vivo.	Dehydroepiandrosterone Sulfate	87-118	interferon gamma	Homo sapiens	295-304
11070351-0	2000	Stimulation of MCF-7 breast cancer cell proliferation by estrone sulfate and dehydroepiandrosterone sulfate: inhibition by novel non-steroidal steroid sulfatase inhibitors.	Dehydroepiandrosterone Sulfate	77-107	steroid sulfatase	Homo sapiens	143-160
11070351-1	2000	Steroid sulfatase (STS) regulates the formation of active steroids from systemic precursors, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	121-151	steroid sulfatase	Homo sapiens	0-17
11070351-1	2000	Steroid sulfatase (STS) regulates the formation of active steroids from systemic precursors, such as estrone sulfate and dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	153-158	steroid sulfatase	Homo sapiens	0-17
10821876-1	2000	Data from animal and in vitro studies suggest that the growth-promoting effects of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by stimulation of insulin-like growth factor-I (IGF-I) and/or inhibition of interleukin 6 (IL-6), a cytokine mediator of bone resorption.	Dehydroepiandrosterone Sulfate	104-134	sulfotransferase family 2A member 1	Homo sapiens	136-141
10821876-1	2000	Data from animal and in vitro studies suggest that the growth-promoting effects of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by stimulation of insulin-like growth factor-I (IGF-I) and/or inhibition of interleukin 6 (IL-6), a cytokine mediator of bone resorption.	Dehydroepiandrosterone Sulfate	104-134	insulin like growth factor 1	Homo sapiens	177-205
10821876-1	2000	Data from animal and in vitro studies suggest that the growth-promoting effects of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by stimulation of insulin-like growth factor-I (IGF-I) and/or inhibition of interleukin 6 (IL-6), a cytokine mediator of bone resorption.	Dehydroepiandrosterone Sulfate	104-134	insulin like growth factor 1	Homo sapiens	207-212
10821876-1	2000	Data from animal and in vitro studies suggest that the growth-promoting effects of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by stimulation of insulin-like growth factor-I (IGF-I) and/or inhibition of interleukin 6 (IL-6), a cytokine mediator of bone resorption.	Dehydroepiandrosterone Sulfate	104-134	interleukin 6	Homo sapiens	235-248
10821876-1	2000	Data from animal and in vitro studies suggest that the growth-promoting effects of the adrenal androgen dehydroepiandrosterone sulfate (DHEAS) may be mediated by stimulation of insulin-like growth factor-I (IGF-I) and/or inhibition of interleukin 6 (IL-6), a cytokine mediator of bone resorption.	Dehydroepiandrosterone Sulfate	104-134	interleukin 6	Homo sapiens	250-254
10822224-2	2000	DESIGN: The results of dehydroepiandrosterone sulfate (DHEAS) measurement were evaluated in a consecutive series of 107 patients with an adrenal mass (39 men, 68 women aged 15-81 years, median 56 years).	Dehydroepiandrosterone Sulfate	23-53	sulfotransferase family 2A member 1	Homo sapiens	55-60
10925210-2	2000	The steroid sulfatase enzyme (STS) catalyzes the conversion of estrone sulfate, dehydroepiandrosterone sulfate, cholesterol sulfate and glucocorticoid sulfates to their active nonconjugated forms.	Dehydroepiandrosterone Sulfate	80-110	steroid sulfatase	Rattus norvegicus	4-28
10843161-1	2000	Dehydroepiandrosterone sulfate (DHEAS) is the major secretory steroid of the human adrenal glands.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
10841075-5	2000	Results indicate that treatment with DHEA or DHEAS significantly increases the serum level of IL-10.	Dehydroepiandrosterone Sulfate	45-50	interleukin 10	Mus musculus	94-99
10841075-6	2000	The spleen cells isolated from the DHEA-treated or DHEAS-treated mice also showed an increase in IL-10 secretion and mRNA expression after the cells were activated by concanavalin A (ConA).	Dehydroepiandrosterone Sulfate	51-56	interleukin 10	Mus musculus	97-102
10792095-1	2000	OBJECTIVES: In 1994, the Massachusetts Male Aging Study presented the finding of an inverse correlation of the serum levels of dehydroepiandrosterone sulfate (DHEAS) and the incidence of erectile dysfunction (ED).	Dehydroepiandrosterone Sulfate	127-157	sulfotransferase family 2A member 1	Homo sapiens	159-164
10938573-0	1999	The enhancement of hippocampal primed burst potentiation by dehydroepiandrosterone sulfate (DHEAS) is blocked by psychological stress.	Dehydroepiandrosterone Sulfate	60-90	sulfotransferase family 2A member 1	Homo sapiens	92-97
10764679-4	2000	Baseline DHEA sulfate (DHEAS) levels were measured in 867 subjects after an overnight fast.	Dehydroepiandrosterone Sulfate	9-21	sulfotransferase family 2A member 1	Homo sapiens	23-28
10803476-8	2000	Both ACTH and cortisol levels were not different in suppressor and nonsuppressor patients, but DHEAS levels were significantly lower in nonsuppressor cases, who also exhibited ACTH and cortisol periodicities more altered than in suppressor and in control subjects.	Dehydroepiandrosterone Sulfate	95-100	proopiomelanocortin	Homo sapiens	176-180
10775806-1	2000	Dehydroepiandrosterone sulfotransferase (DHEA-ST) is a key enzyme in the formation of Dehydroepiandrosterone sulfate (DHEAS) and is thought to be involved in the conversion of various substances such as bile acids and cholesterol.	Dehydroepiandrosterone Sulfate	86-116	sulfotransferase family 2A member 1	Homo sapiens	0-39
10775806-1	2000	Dehydroepiandrosterone sulfotransferase (DHEA-ST) is a key enzyme in the formation of Dehydroepiandrosterone sulfate (DHEAS) and is thought to be involved in the conversion of various substances such as bile acids and cholesterol.	Dehydroepiandrosterone Sulfate	86-116	sulfotransferase family 2A member 1	Homo sapiens	41-48
10775806-1	2000	Dehydroepiandrosterone sulfotransferase (DHEA-ST) is a key enzyme in the formation of Dehydroepiandrosterone sulfate (DHEAS) and is thought to be involved in the conversion of various substances such as bile acids and cholesterol.	Dehydroepiandrosterone Sulfate	118-123	sulfotransferase family 2A member 1	Homo sapiens	0-39
10775806-1	2000	Dehydroepiandrosterone sulfotransferase (DHEA-ST) is a key enzyme in the formation of Dehydroepiandrosterone sulfate (DHEAS) and is thought to be involved in the conversion of various substances such as bile acids and cholesterol.	Dehydroepiandrosterone Sulfate	118-123	sulfotransferase family 2A member 1	Homo sapiens	41-48
10736251-2	2000	16alpha-hydroxy dehydroepiandrosterone sulphate (16alpha-OH-DHEAS) is formed in the fetal liver by hydroxylation of dehydroepiandrosterone sulphate (DHEAS) and transported to the placenta where it undergoes desulphation by steroid sulphatase (STS) and aromatization to oestriol.	Dehydroepiandrosterone Sulfate	16-47	sulfotransferase family 2A member 1	Homo sapiens	60-65
10736251-2	2000	16alpha-hydroxy dehydroepiandrosterone sulphate (16alpha-OH-DHEAS) is formed in the fetal liver by hydroxylation of dehydroepiandrosterone sulphate (DHEAS) and transported to the placenta where it undergoes desulphation by steroid sulphatase (STS) and aromatization to oestriol.	Dehydroepiandrosterone Sulfate	16-47	sulfotransferase family 2A member 1	Homo sapiens	149-154
10736251-2	2000	16alpha-hydroxy dehydroepiandrosterone sulphate (16alpha-OH-DHEAS) is formed in the fetal liver by hydroxylation of dehydroepiandrosterone sulphate (DHEAS) and transported to the placenta where it undergoes desulphation by steroid sulphatase (STS) and aromatization to oestriol.	Dehydroepiandrosterone Sulfate	16-47	steroid sulfatase	Homo sapiens	223-241
10664831-1	2000	BACKGROUND: Previous reports have found low levels of dehydroepiandrosterone sulfate (DHEA-S) in association with physical illness, and with frailty in the elderly.	Dehydroepiandrosterone Sulfate	54-84	sulfotransferase family 2A member 1	Homo sapiens	86-92
10664834-1	2000	BACKGROUND: Cross-sectional studies controlling for age and gender reported a relationship between Alzheimer"s disease and low dehydroepiandrosterone sulphate (DHEA-S) plasma levels.	Dehydroepiandrosterone Sulfate	127-158	sulfotransferase family 2A member 1	Homo sapiens	160-166
10601278-2	1999	A novel human organic transporter, OATP2, has been identified that transports taurocholic acid, the adrenal androgen dehydroepiandrosterone sulfate, and thyroid hormone, as well as the hydroxymethylglutaryl-CoA reductase inhibitor, pravastatin.	Dehydroepiandrosterone Sulfate	117-147	solute carrier organic anion transporter family member 1B1	Homo sapiens	35-40
10726904-1	2000	Familial aggregation and possible major gene effects were evaluated for the baseline serum dehydroepiandrosterone sulfate (DHEAS) level and the change in DHEAS in response to a 20-week exercise training program in a sample of 481 individuals from 99 Caucasian families who were sedentary at baseline and who participated in the HERITAGE Family Study.	Dehydroepiandrosterone Sulfate	91-121	sulfotransferase family 2A member 1	Homo sapiens	123-128
10660625-5	2000	When expressed in Xenopus oocytes, OAT4 mediated the high affinity transport of estrone sulfate (K(m) = 1.01 microM) and dehydroepiandrosterone sulfate (K(m) = 0.63 microM) in a sodium-independent manner.	Dehydroepiandrosterone Sulfate	121-151	solute carrier family 22 member 11	Homo sapiens	35-39
10698044-3	2000	On the other hand, it is well known that mean IGF-I levels are clearly reduced in hypopituitaric patients with GH deficiency (GHD) while data about dehydroepiandrosterone sulfate (DHEA-S) levels in hypopituitarism are scanty.	Dehydroepiandrosterone Sulfate	148-178	sulfotransferase family 2A member 1	Homo sapiens	180-186
10954041-5	2000	ACTH and PRL correlated positively with F, dehydroepiandrosterone-sulphate (DHEAS) and T in females, which suggests that PRL and ACTH could synergistically stimulate adrenal androgen production.	Dehydroepiandrosterone Sulfate	43-74	proopiomelanocortin	Homo sapiens	0-4
10954041-5	2000	ACTH and PRL correlated positively with F, dehydroepiandrosterone-sulphate (DHEAS) and T in females, which suggests that PRL and ACTH could synergistically stimulate adrenal androgen production.	Dehydroepiandrosterone Sulfate	76-81	proopiomelanocortin	Homo sapiens	0-4
10954041-5	2000	ACTH and PRL correlated positively with F, dehydroepiandrosterone-sulphate (DHEAS) and T in females, which suggests that PRL and ACTH could synergistically stimulate adrenal androgen production.	Dehydroepiandrosterone Sulfate	76-81	proopiomelanocortin	Homo sapiens	129-133
10984071-1	2000	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS), the major androgens secreted by human adrenal glands, were suggested to play a protective role in the pathogenesis of atherosclerosis and coronary heart disease.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
11155807-1	2000	The altered cortisol and adrenal androgen (i.e., dehydroepiandrosterone sulfate = DHEAS) secretion, observed during testing in rheumatoid arthritis (RA) patients not treated with corticosteroids, should be clearly regarded as a "relative adrenal insufficiency" in the setting of a sustained inflammatory process, as shown by high serum IL-6 levels.	Dehydroepiandrosterone Sulfate	49-79	sulfotransferase family 2A member 1	Homo sapiens	82-87
11155807-1	2000	The altered cortisol and adrenal androgen (i.e., dehydroepiandrosterone sulfate = DHEAS) secretion, observed during testing in rheumatoid arthritis (RA) patients not treated with corticosteroids, should be clearly regarded as a "relative adrenal insufficiency" in the setting of a sustained inflammatory process, as shown by high serum IL-6 levels.	Dehydroepiandrosterone Sulfate	49-79	interleukin 6	Homo sapiens	336-340
11186254-3	2000	However, recent prospective studies of serum cortisol and dehydroepiandrosterone sulfate (DHEAS) levels before (x = 12 yrs) the onset of the disease (pre-RA) offer an alternative perspective.	Dehydroepiandrosterone Sulfate	58-88	sulfotransferase family 2A member 1	Homo sapiens	90-95
10574821-1	1999	AIMS: To determine whether patients with idiopathic retinal vasculitis have altered production of cortisol and dehydroepiandrosterone sulphate (DHEA-S), and whether differences in these variables occur between those who are sensitive (SS) and resistant (SR) to steroids.	Dehydroepiandrosterone Sulfate	111-142	sulfotransferase family 2A member 1	Homo sapiens	144-150
10938573-1	1999	This series of studies investigated the effects of psychological stress and the neurosteroid dehydroepiandrosterone sulfate (DHEAS) on hippocampal primed burst (PB) and long-term (LTP) potentiation, two electrophysiological models of memory.	Dehydroepiandrosterone Sulfate	93-123	sulfotransferase family 2A member 1	Homo sapiens	125-130
10604493-1	1999	Endogenous dehydroepiandrosterone sulfate (DHEAS) levels have been reported to be positively related to blood pressure levels.	Dehydroepiandrosterone Sulfate	11-41	sulfotransferase family 2A member 1	Homo sapiens	43-48
15251653-1	1999	OBJECTIVE: To determine the levels of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) in women with no clinical signs of hyperandrogenism and no history of glucocorticoid or oral contraceptive use and to compare these levels with the reference ranges provided by commercial laboratories.	Dehydroepiandrosterone Sulfate	61-91	sulfotransferase family 2A member 1	Homo sapiens	93-98
10599744-1	1999	Serum dehydroepiandrosterone-sulfate (DHEAS) is a classic marker for adrenarche and, subsequently, for the individual hormonal milieu.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-43
10561001-8	1999	In normal weight women with PCOS and PAO, leptin correlated positively with body weight and insulin, and negatively with IGFBP-1 and DHEAS.	Dehydroepiandrosterone Sulfate	133-138	leptin	Homo sapiens	42-48
10581651-0	1999	Peripheral steroid sulfatase inhibition potentiates improvement of memory retention for hippocampally administered dehydroepiandrosterone sulfate but not pregnenolone sulfate.	Dehydroepiandrosterone Sulfate	115-145	steroid sulfatase	Mus musculus	11-28
10581651-2	1999	Estrone-3-O-sulfamate (EMATE), a steroid sulfatase inhibitor, potentiates the effect of DHEAS on memory retention such that lower doses of DHEAS improve memory retention.	Dehydroepiandrosterone Sulfate	88-93	steroid sulfatase	Mus musculus	33-50
10581651-2	1999	Estrone-3-O-sulfamate (EMATE), a steroid sulfatase inhibitor, potentiates the effect of DHEAS on memory retention such that lower doses of DHEAS improve memory retention.	Dehydroepiandrosterone Sulfate	139-144	steroid sulfatase	Mus musculus	33-50
11212304-0	1999	The in vitro antiapoptotic effect of dehydroepiandrosterone sulfate in mouse thymocytes and its relation to caspase-3/caspase-6.	Dehydroepiandrosterone Sulfate	37-67	caspase 3	Mus musculus	108-117
11212304-0	1999	The in vitro antiapoptotic effect of dehydroepiandrosterone sulfate in mouse thymocytes and its relation to caspase-3/caspase-6.	Dehydroepiandrosterone Sulfate	37-67	caspase 6	Mus musculus	118-127
10523022-0	1999	Corticotropin-releasing hormone stimulates P450 17alpha-hydroxylase/17,20-lyase in human fetal adrenal cells via protein kinase C. CRH directly stimulates dehydroepiandrosterone sulfate (DHEAS) production in human fetal adrenal cells.	Dehydroepiandrosterone Sulfate	187-192	corticotropin releasing hormone	Homo sapiens	131-134
10843528-0	1999	Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
10523022-0	1999	Corticotropin-releasing hormone stimulates P450 17alpha-hydroxylase/17,20-lyase in human fetal adrenal cells via protein kinase C. CRH directly stimulates dehydroepiandrosterone sulfate (DHEAS) production in human fetal adrenal cells.	Dehydroepiandrosterone Sulfate	155-185	corticotropin releasing hormone	Homo sapiens	131-134
10595831-2	1999	Sex and age are the major determinants of serum levels of dehydroepiandrosterone sulfate (DHEA-S): they are about twice in men than in women and show a progressive reduction from the end of the puberty to aging in both sexes.	Dehydroepiandrosterone Sulfate	58-88	sulfotransferase family 2A member 1	Homo sapiens	90-96
10580835-2	1999	We found that CRH, at concentrations that have been reported to exist in human fetal serum, stimulated dehydroepiandrosterone sulfate (DS) and cortisol production by cultured fetal zone and neocortical zone cells.	Dehydroepiandrosterone Sulfate	103-133	corticotropin releasing hormone	Homo sapiens	14-17
10580835-2	1999	We found that CRH, at concentrations that have been reported to exist in human fetal serum, stimulated dehydroepiandrosterone sulfate (DS) and cortisol production by cultured fetal zone and neocortical zone cells.	Dehydroepiandrosterone Sulfate	135-137	corticotropin releasing hormone	Homo sapiens	14-17
10580744-0	1999	A close association between insulin resistance and dehydroepiandrosterone sulfate in subjects with essential hypertension.	Dehydroepiandrosterone Sulfate	51-81	insulin	Homo sapiens	28-35
10580744-1	1999	To examine the serum levels of dehydroepiandrosterone sulfate (DHEAS) and its relation with insulin resistance and the other risk factors in essential hypertension, serum DHEAS and insulin sensitivity were assessed in 35 male hypertensive and 17 male healthy control subjects aged 50-59 years.	Dehydroepiandrosterone Sulfate	31-61	sulfotransferase family 2A member 1	Homo sapiens	63-68
10580744-1	1999	To examine the serum levels of dehydroepiandrosterone sulfate (DHEAS) and its relation with insulin resistance and the other risk factors in essential hypertension, serum DHEAS and insulin sensitivity were assessed in 35 male hypertensive and 17 male healthy control subjects aged 50-59 years.	Dehydroepiandrosterone Sulfate	31-61	insulin	Homo sapiens	92-99
10438436-1	1999	The purpose of this study was to evaluate the role of nitric oxide in the vasodilative effect of dehydroepiandrosterone sulphate (DHEA-S) in term pregnant women.	Dehydroepiandrosterone Sulfate	97-128	sulfotransferase family 2A member 1	Homo sapiens	130-136
10487697-0	1999	Dehydroepiandrosterone sulfate enhances natural killer cell cytotoxicity in humans via locally generated immunoreactive insulin-like growth factor I.	Dehydroepiandrosterone Sulfate	0-30	insulin like growth factor 1	Homo sapiens	120-148
10487697-1	1999	Experimental and clinical investigations suggest the hypothesis that dehydroepiandrosterone sulfate (DHEAS) can positively influence natural killer (NK) immunity via locally produced insulin-like growth factor I (IGF-I) from NK cells.	Dehydroepiandrosterone Sulfate	69-99	sulfotransferase family 2A member 1	Homo sapiens	101-106
10487697-1	1999	Experimental and clinical investigations suggest the hypothesis that dehydroepiandrosterone sulfate (DHEAS) can positively influence natural killer (NK) immunity via locally produced insulin-like growth factor I (IGF-I) from NK cells.	Dehydroepiandrosterone Sulfate	69-99	insulin like growth factor 1	Homo sapiens	183-211
10487697-1	1999	Experimental and clinical investigations suggest the hypothesis that dehydroepiandrosterone sulfate (DHEAS) can positively influence natural killer (NK) immunity via locally produced insulin-like growth factor I (IGF-I) from NK cells.	Dehydroepiandrosterone Sulfate	69-99	insulin like growth factor 1	Homo sapiens	213-218
10473054-8	1999	Serum dehydroepiandrosterone-sulfate rose swiftly within 3 h of hCRH infusion and remained unchanged after saline (mean increase 37 versus 1%; p &lt; 0.01).	Dehydroepiandrosterone Sulfate	6-36	corticotropin releasing hormone	Homo sapiens	64-68
10523022-7	1999	CRH increased DHEAS production, with a much lesser effect on cortisol.	Dehydroepiandrosterone Sulfate	14-19	corticotropin releasing hormone	Homo sapiens	0-3
10523022-12	1999	Thus, CRH is coupled to the phospholipase C-inositol phosphate second messenger system and preferentially induces the expression of P450c17 and DHEAS, suggesting a unique role of CRH regulating human fetal adrenal function via PKC.	Dehydroepiandrosterone Sulfate	144-149	corticotropin releasing hormone	Homo sapiens	6-9
10523022-12	1999	Thus, CRH is coupled to the phospholipase C-inositol phosphate second messenger system and preferentially induces the expression of P450c17 and DHEAS, suggesting a unique role of CRH regulating human fetal adrenal function via PKC.	Dehydroepiandrosterone Sulfate	144-149	corticotropin releasing hormone	Homo sapiens	179-182
10596729-3	1999	He received the DHEA sulfate (DHEA-S) infusion test to evaluate aromatase activity.	Dehydroepiandrosterone Sulfate	16-28	sulfotransferase family 2A member 1	Homo sapiens	30-36
10341026-9	1999	Both carnitine and DHEAS alone and in an additive fashion increased ALP activity and COL levels.	Dehydroepiandrosterone Sulfate	19-24	alkaline phosphatase, placental	Homo sapiens	68-71
21432177-1	1999	In this cross-sectional study, the relationships of the physiological levels of estradiol (E2) and dehydroepiandrosterone-sulfate (DHEA-S) to the lipid and lipoprotein profiles were investigated in 212 apparently healthy men aged from 18 to 59 years old.	Dehydroepiandrosterone Sulfate	99-129	sulfotransferase family 2A member 1	Homo sapiens	131-137
10373337-0	1999	Relationships between dehydroepiandrosterone sulfate (DHEAS) and cortisol (CRT) plasma levels and everyday memory in Alzheimer"s disease patients compared to healthy controls.	Dehydroepiandrosterone Sulfate	22-52	sulfotransferase family 2A member 1	Homo sapiens	54-59
10411234-9	1999	In OB women, IGF-I concentrations positively correlated with PRL (r = 0.31), testosterone (r = 0.30), androstenedione (r = 0.30), and dehydroepiandrosterone-sulfate (DHEAS) concentrations (r = 0.41).	Dehydroepiandrosterone Sulfate	134-164	insulin like growth factor 1	Homo sapiens	13-18
10411234-9	1999	In OB women, IGF-I concentrations positively correlated with PRL (r = 0.31), testosterone (r = 0.30), androstenedione (r = 0.30), and dehydroepiandrosterone-sulfate (DHEAS) concentrations (r = 0.41).	Dehydroepiandrosterone Sulfate	166-171	insulin like growth factor 1	Homo sapiens	13-18
10076188-0	1999	Dihydrotestosterone, stanozolol, androstenedione and dehydroepiandrosterone sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro: lack of effect of testosterone.	Dehydroepiandrosterone Sulfate	53-84	leptin	Homo sapiens	93-99
10325294-1	1999	Hyaluronic acid (HA) stimulates the synthesis of interleukin (IL) 8, while dehydroepiandrosterone sulphate (DHEA-S) induces the expression of IL-8 and its receptor in the human cervical fibroblast.	Dehydroepiandrosterone Sulfate	75-106	sulfotransferase family 2A member 1	Homo sapiens	108-114
10325294-1	1999	Hyaluronic acid (HA) stimulates the synthesis of interleukin (IL) 8, while dehydroepiandrosterone sulphate (DHEA-S) induces the expression of IL-8 and its receptor in the human cervical fibroblast.	Dehydroepiandrosterone Sulfate	75-106	C-X-C motif chemokine ligand 8	Homo sapiens	142-146
10376266-9	1999	Placental corticotropin-releasing factor is also secreted into the fetal circulation and the stimulation of fetal pituitary ACTH and fetal adrenal gland dehydroepiandrosterone sulfate release in vitro has been shown.	Dehydroepiandrosterone Sulfate	153-183	corticotropin releasing hormone	Homo sapiens	10-40
10076188-11	1999	Dehydroepiandrosterone sulphate (DHEA-S) induced a significant (P&lt;0.01) leptin decrease in female samples (2996+/-473), with no modifications in samples derived from males (1596+/-528).	Dehydroepiandrosterone Sulfate	0-31	leptin	Homo sapiens	75-81
10084576-1	1999	Adrenal androgen (AA) excess, primarily in the form of dehydroepiandrosterone sulfate (DHEAS), affects over 50% of women with the polycystic ovary syndrome (PCOS).	Dehydroepiandrosterone Sulfate	55-85	sulfotransferase family 2A member 1	Homo sapiens	87-92
10076188-11	1999	Dehydroepiandrosterone sulphate (DHEA-S) induced a significant (P&lt;0.01) leptin decrease in female samples (2996+/-473), with no modifications in samples derived from males (1596+/-528).	Dehydroepiandrosterone Sulfate	33-39	leptin	Homo sapiens	75-81
10076188-13	1999	In conclusion, DHT, stanozolol, DHEA-S and androstenedione induced a significant inhibition of in vitro leptin secretion in samples from female donors, without affecting the secretion in samples from men.	Dehydroepiandrosterone Sulfate	32-38	leptin	Homo sapiens	104-110
10094486-4	1999	Functionally, the oatp2-expressing oocytes were found to transport dehydroepiandrosterone sulfate, delta1 opioid receptor agonist [D-Pen2,D-Pen5]enkephalin, Leuenkephalin, and biotin significantly, as well as the substrates previously reported.	Dehydroepiandrosterone Sulfate	67-97	solute carrier organic anion transporter family, member 1a4	Rattus norvegicus	18-23
10337439-1	1999	Dehydroepiandrosterone sulfate (DHEAS) was measured in a five-year follow-up study of random persons of three age cohorts (75-, 80-, and 85-years, N = 571) in order to investigate its associations with clinical diseases and their risk indicators, as well as its prognostic significance in old age.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
10099969-5	1999	Serum IGF-I was only correlated with basal dehydroepiandrosterone sulphate (DHEA-S), while insulin exhibited a strong correlation with the delta 4 pathway and androstenedione formation in particular.	Dehydroepiandrosterone Sulfate	43-74	insulin like growth factor 1	Homo sapiens	6-11
10099969-5	1999	Serum IGF-I was only correlated with basal dehydroepiandrosterone sulphate (DHEA-S), while insulin exhibited a strong correlation with the delta 4 pathway and androstenedione formation in particular.	Dehydroepiandrosterone Sulfate	76-82	insulin like growth factor 1	Homo sapiens	6-11
10201649-6	1999	Both DHEA and DHEAS were positively related to diastolic and systolic blood pressure, and DHEAS was negatively related to apolipoprotein A.	Dehydroepiandrosterone Sulfate	90-95	lipoprotein(a)	Homo sapiens	122-138
9927050-1	1999	Steroid sulfatase (STS) hydrolyzes several sulfated steroids such as estrone sulfate, dehydroepiandrosterone sulfate, and cholesterol sulfate.	Dehydroepiandrosterone Sulfate	86-116	steroid sulfatase	Homo sapiens	0-17
9930762-1	1999	Biosynthesis of the neuroactive steroids pregnenolone sulfate (delta5PS) and dehydroepiandrosterone sulfate (DHEAS) is catalyzed by the enzyme hydroxysteroid sulfotransferase (HST), which transfers the sulfonate moiety from 3"-phosphoadenosine 5"-phosphosulfate (PAPS) on the 3-hydroxy site of steroids.	Dehydroepiandrosterone Sulfate	77-107	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Rattus norvegicus	143-174
9930762-1	1999	Biosynthesis of the neuroactive steroids pregnenolone sulfate (delta5PS) and dehydroepiandrosterone sulfate (DHEAS) is catalyzed by the enzyme hydroxysteroid sulfotransferase (HST), which transfers the sulfonate moiety from 3"-phosphoadenosine 5"-phosphosulfate (PAPS) on the 3-hydroxy site of steroids.	Dehydroepiandrosterone Sulfate	77-107	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Rattus norvegicus	176-179
9930762-1	1999	Biosynthesis of the neuroactive steroids pregnenolone sulfate (delta5PS) and dehydroepiandrosterone sulfate (DHEAS) is catalyzed by the enzyme hydroxysteroid sulfotransferase (HST), which transfers the sulfonate moiety from 3"-phosphoadenosine 5"-phosphosulfate (PAPS) on the 3-hydroxy site of steroids.	Dehydroepiandrosterone Sulfate	109-114	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Rattus norvegicus	143-174
9930762-1	1999	Biosynthesis of the neuroactive steroids pregnenolone sulfate (delta5PS) and dehydroepiandrosterone sulfate (DHEAS) is catalyzed by the enzyme hydroxysteroid sulfotransferase (HST), which transfers the sulfonate moiety from 3"-phosphoadenosine 5"-phosphosulfate (PAPS) on the 3-hydroxy site of steroids.	Dehydroepiandrosterone Sulfate	109-114	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2	Rattus norvegicus	176-179
9884478-1	1998	Dehydroepiandrosterone sulfate (DHEAS) is a major secretory product of the adrenal glands.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
10364627-6	1999	RESULTS: Using linear regression modeling, serum leptin levels were inversely associated with testosterone and positively associated with estradiol and dehydroepiandrosterone sulfate, after adjustment for the other hormones and body mass index (BMI).	Dehydroepiandrosterone Sulfate	152-182	leptin	Homo sapiens	49-55
9844034-0	1999	Dehydroepiandrosterone sulfate decreases the interleukin-2-mediated overactivity of the natural killer cell compartment in senile dementia of the Alzheimer type.	Dehydroepiandrosterone Sulfate	0-30	interleukin 2	Homo sapiens	45-58
9844034-1	1999	Since dehydroepiandrosterone sulfate (DHEAS) has been involved in the regulation of cellular immunity, the aim of the presence study was to evaluate whether the age-dependent reduction of DHEAS was associated with changes of natural killer (NK) immune function in healthy elderly subjects and in patients with senile dementia of the Alzheimer type (SDAT).	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-43
9844034-1	1999	Since dehydroepiandrosterone sulfate (DHEAS) has been involved in the regulation of cellular immunity, the aim of the presence study was to evaluate whether the age-dependent reduction of DHEAS was associated with changes of natural killer (NK) immune function in healthy elderly subjects and in patients with senile dementia of the Alzheimer type (SDAT).	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	188-193
10727032-0	1999	Dehydroepiandrosterone-sulfate (DHEA-S) restores the release of IGF-I from natural killer (NK) immune in old patients with dementia of Alzheimer"s type (DAT).	Dehydroepiandrosterone Sulfate	0-30	insulin like growth factor 1	Homo sapiens	64-69
10727032-0	1999	Dehydroepiandrosterone-sulfate (DHEA-S) restores the release of IGF-I from natural killer (NK) immune in old patients with dementia of Alzheimer"s type (DAT).	Dehydroepiandrosterone Sulfate	32-38	insulin like growth factor 1	Homo sapiens	64-69
10064172-1	1999	We measured cerebrospinal fluid (CSF) levels of dehydroepiandrosterone sulfate (DHEAS) by radioimmunoassay in seven patients with multi-infarct dementia (MID), fourteen age- and gender-matched non-demented patients with a history of cerebral infarction and fifteen age- and gender-matched patients without neurological disorders.	Dehydroepiandrosterone Sulfate	48-78	sulfotransferase family 2A member 1	Homo sapiens	80-85
10403489-0	1999	Specific binding and effects of dehydroepiandrosterone sulfate (DHEA-S) on skeletal muscle cells: possible implication for DHEA-S replacement therapy in patients with myotonic dystrophy.	Dehydroepiandrosterone Sulfate	32-62	sulfotransferase family 2A member 1	Homo sapiens	64-70
10403489-0	1999	Specific binding and effects of dehydroepiandrosterone sulfate (DHEA-S) on skeletal muscle cells: possible implication for DHEA-S replacement therapy in patients with myotonic dystrophy.	Dehydroepiandrosterone Sulfate	32-62	sulfotransferase family 2A member 1	Homo sapiens	123-129
9820396-1	1998	OBJECTIVES: Dehydroepiandrosterone sulfate (DHEAS) and cortisol are multifunctional adrenal hormones with immunomodulating properties.	Dehydroepiandrosterone Sulfate	12-42	sulfotransferase family 2A member 1	Homo sapiens	44-49
10091201-1	1998	OBJECTIVES: Positive association between serum dehydroepiandrosterone sulfate (DHEAS) and high-density lipoprotein (HDL) cholesterol has been observed in men but not women.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-84
10408670-7	1998	RESULTS: In women, DHEAS correlated with VO2max (partial correlation: r=0.33; P=0.05), MHDEE (r=0.50; P=0.002), DEE &gt; 3 METs (r=0.49; P=0.003) and sport activity (r=0.35; P=0.04) whereas IGF-I correlated with MHDEE (r=0.48; P=0.004).	Dehydroepiandrosterone Sulfate	19-24	insulin like growth factor 1	Homo sapiens	190-195
10408670-8	1998	DHEAS was correlated with IGF-I (r=0.43; P &lt; 0.02) and with testosterone (r=0.41; P &lt; 0.02).	Dehydroepiandrosterone Sulfate	0-5	insulin like growth factor 1	Homo sapiens	26-31
9851286-0	1998	Serum dehydroepiandrosterone sulphate levels in patients with early rheumatoid arthritis: positive association with C-reactive protein, but not with HLA-DR genotype.	Dehydroepiandrosterone Sulfate	6-37	C-reactive protein	Homo sapiens	116-134
9703482-11	1998	Thus, despite its unresponsiveness to steroidal peroxisome proliferators in transfection assays, PPAR alpha is an obligatory mediator of DHEA-S-stimulated hepatic peroxisomal gene induction.	Dehydroepiandrosterone Sulfate	137-143	peroxisome proliferator activated receptor alpha	Mus musculus	97-107
9951633-6	1998	Recent studies have shown that DHEA-sulfate (DHEA-S), but not DHEA, activates peroxisome proliferator-activated receptor alpha (PPAR alpha) in the liver, an intracellular receptor belonging to the steroid receptor superfamily.	Dehydroepiandrosterone Sulfate	31-43	sulfotransferase family 2A member 1	Homo sapiens	45-51
9951633-6	1998	Recent studies have shown that DHEA-sulfate (DHEA-S), but not DHEA, activates peroxisome proliferator-activated receptor alpha (PPAR alpha) in the liver, an intracellular receptor belonging to the steroid receptor superfamily.	Dehydroepiandrosterone Sulfate	31-43	peroxisome proliferator activated receptor alpha	Homo sapiens	78-126
9951633-6	1998	Recent studies have shown that DHEA-sulfate (DHEA-S), but not DHEA, activates peroxisome proliferator-activated receptor alpha (PPAR alpha) in the liver, an intracellular receptor belonging to the steroid receptor superfamily.	Dehydroepiandrosterone Sulfate	31-43	peroxisome proliferator activated receptor alpha	Homo sapiens	128-138
9793575-1	1998	Previous reports have found low levels of dehydroepiandrosterone sulfate (DHEA-S) in association with frailty in elderly patients.	Dehydroepiandrosterone Sulfate	42-72	sulfotransferase family 2A member 1	Homo sapiens	74-80
9859027-7	1998	Serum DHEAS levels were similar in POF patients and in fertile controls and higher with respect to postmenopausal women.	Dehydroepiandrosterone Sulfate	6-11	POF1B actin binding protein	Homo sapiens	35-38
9768686-14	1998	These findings suggest that as children mature there is a decreased level of 3betaHSD in the adrenal reticularis that may contribute to the increased production of DHEA and DHEAS seen during adrenarche.	Dehydroepiandrosterone Sulfate	173-178	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	77-85
9824214-1	1998	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are endogenous steroids that have recently been widely publicized as potential treatments for many disorders.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
9779307-1	1998	OBJECTIVE: To evaluate the levels of dehydroepiandrosterone sulphate (DHEAS) in the blood and tissues of patients with inflammatory bowel disease (IBD).	Dehydroepiandrosterone Sulfate	37-68	sulfotransferase family 2A member 1	Homo sapiens	70-75
9709969-0	1998	Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells.	Dehydroepiandrosterone Sulfate	71-101	corticotropin releasing hormone	Homo sapiens	0-31
9709969-2	1998	The placentae of humans and higher primates use the C19 androgen dehydroepiandrosterone sulfate (DHEA-S) supplied by the fetal adrenals as the principal substrate for estrogen synthesis.	Dehydroepiandrosterone Sulfate	65-95	sulfotransferase family 2A member 1	Homo sapiens	97-103
9678543-1	1998	Chronic feeding of dehydroepiandrosterone (DHEA) and its sulfated metabolite, dehydroepiandrosterone sulfate (DHEAS), has previously been reported to decrease hyperglycemia, obesity, cancer, and autoantibody generation in a number of animal models and to increase muscle mass and physiological and psychological well-being in elderly humans, although these latter studies remain controversial.	Dehydroepiandrosterone Sulfate	78-108	sulfotransferase family 2A member 1	Homo sapiens	110-115
9710041-2	1998	administration of a dehydroepiandrosterone sulfate (DHEAS) preparation (200 mg/day for 8 weeks) in 11 patients with myotonic dystrophy (MyD).	Dehydroepiandrosterone Sulfate	20-50	sulfotransferase family 2A member 1	Homo sapiens	52-57
9667025-1	1998	A method for the determination of dehydroepiandrosterone sulphate (DHEA-S) in biological samples is described.	Dehydroepiandrosterone Sulfate	34-65	sulfotransferase family 2A member 1	Homo sapiens	67-73
10079390-0	1998	Dehydroepiandrosterone sulfate (DHEAS) secretion in early and advanced solid neoplasms: selective deficiency in metastatic disease.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
10079390-3	1998	Recently, another hormone, the adrenal steroid dehydroepiandrosterone-sulfate (DHEAS), has appeared to exert antitumor effects similar to those previously described for MLT.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-84
9626133-0	1998	Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence.	Dehydroepiandrosterone Sulfate	40-52	interleukin 6	Homo sapiens	90-103
9695345-3	1998	During the process of physiological aging three hormonal systems show the decrease in circulating hormone concentrations: estrogen (menopause), testosterone (andropause) dehydroepiandrosterone sulfate (adrenopause) growth hormone and it"s tissue mediator IGH-I (somatopause).	Dehydroepiandrosterone Sulfate	170-200	growth hormone 1	Homo sapiens	215-229
9626133-0	1998	Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence.	Dehydroepiandrosterone Sulfate	40-52	interleukin 6	Homo sapiens	105-109
9676900-6	1998	The hypophagic effect of DHEAS (10 mg/kg) was reversed by dizocilpine (10 microg/kg), an NMDA receptor antagonist, but resistant to muscimol (0.1 mg/kg), a selective GABA-A receptor agonist.	Dehydroepiandrosterone Sulfate	25-30	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1	Mus musculus	166-172
12016909-4	1998	DHEAS (25, 50, 100 micrograms.L-1) concentration-dependently increased the number of surviving neurons and the activities of SOD and GSH-Px.	Dehydroepiandrosterone Sulfate	0-5	glutathione peroxidase 1	Rattus norvegicus	133-139
9691760-7	1998	We hold that the stress response is a series of biological processes, beginning with CRH.ACTH and Catecholamines, Cortisol (17-OHCS), followed by Insulin, acting as an anabolic agent and finally DHEA-S (17-KS-S) induces tissue repair utilizing the energy produced.	Dehydroepiandrosterone Sulfate	195-201	insulin	Homo sapiens	146-153
9633788-1	1998	Decreased diurnal blood pressure variability and low dehydroepiandrosterone sulfate (DHEAS) levels are important predictors of cardiovascular morbidity and mortality.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	85-90
9625374-0	1998	Effect of dehydroepiandrosterone sulfate on interleukin-8 receptor during cervical ripening.	Dehydroepiandrosterone Sulfate	10-40	C-X-C motif chemokine ligand 8	Homo sapiens	44-57
9741311-3	1998	Pre-illness serum specimens for the assay of testosterone and dehydroepiandrosterone sulphate (DHEAS) were available from 116 cases who had developed RA by late 1989.	Dehydroepiandrosterone Sulfate	62-93	sulfotransferase family 2A member 1	Homo sapiens	95-100
9673390-2	1998	Estrogen receptor activation by estrogens and steroid sulfates such as estrone 3-sulfate (E1S), estradiol 3-sulfate (E2S), estriol 3-sulfate (E3S) and dehydroepiandrosterone sulfate (DHEAS) were studied and compared in these cell lines.	Dehydroepiandrosterone Sulfate	151-181	estrogen receptor 1	Homo sapiens	0-17
9625374-1	1998	We investigated the effects of dehydroepiandrosterone sulfate (DHA-S) on the production of interleukin-8 (IL-8) and expression of the interleukin-8 receptor (IL-8 R) in human cervical tissue.	Dehydroepiandrosterone Sulfate	31-61	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
9625374-1	1998	We investigated the effects of dehydroepiandrosterone sulfate (DHA-S) on the production of interleukin-8 (IL-8) and expression of the interleukin-8 receptor (IL-8 R) in human cervical tissue.	Dehydroepiandrosterone Sulfate	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
9625374-1	1998	We investigated the effects of dehydroepiandrosterone sulfate (DHA-S) on the production of interleukin-8 (IL-8) and expression of the interleukin-8 receptor (IL-8 R) in human cervical tissue.	Dehydroepiandrosterone Sulfate	63-68	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
9625374-2	1998	DHA-S increased the levels of IL-8 in cultured human cervical fibroblasts and in the supernatant in a time- and dose-dependent manner.	Dehydroepiandrosterone Sulfate	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
9625374-3	1998	DHA-S induced IL-8 and IL-8 R expression in human cervical fibroblasts and human pregnant cervical tissue at term in a dose-dependent manner.	Dehydroepiandrosterone Sulfate	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
9625374-3	1998	DHA-S induced IL-8 and IL-8 R expression in human cervical fibroblasts and human pregnant cervical tissue at term in a dose-dependent manner.	Dehydroepiandrosterone Sulfate	0-5	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
9625374-6	1998	These results suggest that DHA-S up-regulates the autocrine system of IL-8 through the expression of IL-8 R.	Dehydroepiandrosterone Sulfate	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
9625374-6	1998	These results suggest that DHA-S up-regulates the autocrine system of IL-8 through the expression of IL-8 R.	Dehydroepiandrosterone Sulfate	27-32	C-X-C motif chemokine ligand 8	Homo sapiens	101-105
9639222-4	1998	Significant positive correlations were observed between GH and T, E2 and DHEAS.	Dehydroepiandrosterone Sulfate	73-78	growth hormone 1	Homo sapiens	56-58
9539693-0	1998	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
9361686-2	1997	This study aims to investigate the role that age-related differences in plasma dehydroepiandrosterone sulfate (DHEAS) concentration may have on insulin action.	Dehydroepiandrosterone Sulfate	79-109	sulfotransferase family 2A member 1	Homo sapiens	111-116
9479557-0	1997	Relationship between insulin sensitivity and dehydroepiandrosterone sulfate in patients with ischemic heart disease.	Dehydroepiandrosterone Sulfate	45-75	insulin	Homo sapiens	21-28
9479557-2	1997	Dehydroepiandrosterone sulfate (DHEA-S) has been suggested as the possible link between these two entities.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-38
9626151-5	1998	Plasma levels of dehydroepiandrosterone sulfate (DHEAS) were elevated with diet L (6.5 +/- 1.4 vs. 5.3 +/- 1.1 mumol/L; P &lt; 0.05) compared to diet N, whereas other plasma hormones, including cortisol and insulin-like growth factor I did not vary markedly.	Dehydroepiandrosterone Sulfate	17-47	sulfotransferase family 2A member 1	Homo sapiens	49-54
9680193-4	1998	However, the antibody cross-reacts about 1% with dehydroepiandrosterone sulfate (DHEAS) and owing to the high DHEAS serum concentration this is about 1000-fold too high for clinical immunoassays.	Dehydroepiandrosterone Sulfate	49-79	sulfotransferase family 2A member 1	Homo sapiens	81-86
9539145-0	1998	Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
9539145-1	1998	Dehydroepiandrosterone sulfate (DHEAS) is the major circulating steroid in man.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
9514370-1	1998	OBJECTIVES: To determine the association of dehydroepiandrosterone sulfate (DHEAS), body composition, and physical fitness in independent community-dwelling men and women aged 60 to 80 years.	Dehydroepiandrosterone Sulfate	44-74	sulfotransferase family 2A member 1	Homo sapiens	76-81
10682483-5	1998	Following ACTH stimulation, PCOS subjects, especially of Group 2 with obvious insulin resistance, showed higher responses of cortisol, dehydroepiandrosterone sulfate and testosterone as compared with the controls.	Dehydroepiandrosterone Sulfate	135-165	insulin	Homo sapiens	78-85
9465106-0	1998	Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity.	Dehydroepiandrosterone Sulfate	34-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
9720981-2	1998	We investigated plasma dehydroepiandrosterone sulfate (DHEAS) and cortisol levels in 12 patients with unipolar depression and 11 matched normal controls.	Dehydroepiandrosterone Sulfate	23-53	sulfotransferase family 2A member 1	Homo sapiens	55-60
9361686-2	1997	This study aims to investigate the role that age-related differences in plasma dehydroepiandrosterone sulfate (DHEAS) concentration may have on insulin action.	Dehydroepiandrosterone Sulfate	79-109	insulin	Homo sapiens	144-151
9357810-7	1997	Myosin heavy-chain synthesis rate was correlated with measures of muscle strength (P &lt; 0.05), circulating insulin-like growth factor I (P &lt; 0.01), and dehydroepiandrosterone sulfate (P &lt; 0.05) in men and women and free testosterone levels in men (P &lt; 0.01).	Dehydroepiandrosterone Sulfate	157-187	myosin heavy chain 14	Homo sapiens	0-6
9141522-1	1997	The fetal zone is a unique adrenal cortical compartment that exists only during fetal life in humans and higher primates and produces large amounts of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	172-202	sulfotransferase family 2A member 1	Homo sapiens	204-210
9225839-0	1997	Effects of aging on dehydroepiandrosterone sulfate in relation to fasting insulin levels and body composition assessed by bioimpedance analysis.	Dehydroepiandrosterone Sulfate	20-50	insulin	Homo sapiens	74-81
9225839-3	1997	The aim of this study was to assess if the aging-related differences in DHEA sulfate (DHEA-S) serum levels can be associated with differences in fasting insulin levels, as well as body composition.	Dehydroepiandrosterone Sulfate	72-84	sulfotransferase family 2A member 1	Homo sapiens	86-92
9225839-3	1997	The aim of this study was to assess if the aging-related differences in DHEA sulfate (DHEA-S) serum levels can be associated with differences in fasting insulin levels, as well as body composition.	Dehydroepiandrosterone Sulfate	72-84	insulin	Homo sapiens	153-160
9189266-4	1997	The authors now report that chronic exposure to high levels of dehydroepiandrosterone sulfate (DHEA-S; converted in vivo to DHEA) produced the same pattern of results as adrenalectomy.	Dehydroepiandrosterone Sulfate	63-93	sulfotransferase family 2A member 1	Homo sapiens	95-101
9148971-5	1997	Stimulation of quiescent ML457 cells with monoethylhexyl phthalate, ciprofibrate ethyl ester, and clofibrate also resulted in tyrosine phosphorylation of ERK1 and ERK2; however, the steroid PP dehydroepiandrosterone sulfate, which does not induce immediate-early gene expression, did not induce phosphorylation of ERK1 and ERK2.	Dehydroepiandrosterone Sulfate	193-223	mitogen-activated protein kinase 3	Mus musculus	154-158
9331084-3	1997	Five days of treatment with the TK inhibitor oxythiamine (OT) and the G6PD inhibitor dehydroepiandrosterone-sulfate (0.5 microM each) exerted a 39 and a 23% maximum inhibitory effect on cell proliferation in culture, which was increased to 60% when the two drugs were administered in combination.	Dehydroepiandrosterone Sulfate	85-115	glucose-6-phosphate dehydrogenase 2	Mus musculus	70-74
9250451-5	1997	Using multiple regression analysis, HbA1c, insulin dose, and DHEAS were significantly correlated to IGF-I SD score (R2 = 0.253, P = 0.001).	Dehydroepiandrosterone Sulfate	61-66	insulin like growth factor 1	Homo sapiens	100-105
9100552-2	1997	Relative insufficiencies of IGF-I and dehydroepiandrosterone sulphate (DHEAS) might be additional risk factors for low bone density in these patients.	Dehydroepiandrosterone Sulfate	38-69	sulfotransferase family 2A member 1	Homo sapiens	71-76
9155639-6	1997	DHEAS supplement prevented loss of cytokines [interleukin-2 (IL-2) and interferon-gamma] secretion by mitogen-stimulated splenocytes representing T helper 1 (Th1) cell phenotypes.	Dehydroepiandrosterone Sulfate	0-5	interleukin 2	Mus musculus	46-59
9155639-6	1997	DHEAS supplement prevented loss of cytokines [interleukin-2 (IL-2) and interferon-gamma] secretion by mitogen-stimulated splenocytes representing T helper 1 (Th1) cell phenotypes.	Dehydroepiandrosterone Sulfate	0-5	interleukin 2	Mus musculus	61-65
9155639-6	1997	DHEAS supplement prevented loss of cytokines [interleukin-2 (IL-2) and interferon-gamma] secretion by mitogen-stimulated splenocytes representing T helper 1 (Th1) cell phenotypes.	Dehydroepiandrosterone Sulfate	0-5	interferon gamma	Mus musculus	71-87
9155639-8	1997	The highest dose of DHEAS reduced IL-6 production by splenocytes from uninfected old mice by 75% while increasing their IL-2 secretion by nearly 50%.	Dehydroepiandrosterone Sulfate	20-25	interleukin 6	Mus musculus	34-38
9155639-8	1997	The highest dose of DHEAS reduced IL-6 production by splenocytes from uninfected old mice by 75% while increasing their IL-2 secretion by nearly 50%.	Dehydroepiandrosterone Sulfate	20-25	interleukin 2	Mus musculus	120-124
8954073-0	1996	Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected tumors.	Dehydroepiandrosterone Sulfate	4-34	sulfotransferase family 2A member 1	Homo sapiens	36-42
9078549-1	1997	Dehydroepiandrosterone sulfate (DHEAS) is prenatally secreted by the fetal adrenal, is an indicator of adrenarche from late childhood onward and is a marker of the individual hormonal milieu in the adult.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
9059510-1	1997	Alteration in energy metabolism of postmenopausal women might be related to the reduction of dehydroepiandrosterone sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	93-123	sulfotransferase family 2A member 1	Homo sapiens	125-130
9043970-5	1997	In contrast, rats treated with both levels of DHEAS had lighter fat pads, fewer epididymal and retroperitoneal adipocytes, less carcass lipid, lower levels of serum triglycerides and greater BAT mass and UCP content than control rats.	Dehydroepiandrosterone Sulfate	46-51	uncoupling protein 1	Rattus norvegicus	204-207
9141538-0	1997	Circulating levels of insulin-like growth factor (IGF) binding protein-1 and -3 in aging men: relationships to insulin, glucose, IGF, and dehydroepiandrosterone sulfate levels and anthropometric measures.	Dehydroepiandrosterone Sulfate	138-168	insulin like growth factor binding protein 1	Homo sapiens	22-79
9059564-1	1997	OBJECTIVE: Insulin was found to decrease the concentration of serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEAS) and recent data suggest that an increase in the metabolic clearance rate of DHEA (MCRDHEA) may be involved.	Dehydroepiandrosterone Sulfate	102-115	insulin	Homo sapiens	11-18
9059564-1	1997	OBJECTIVE: Insulin was found to decrease the concentration of serum dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEAS) and recent data suggest that an increase in the metabolic clearance rate of DHEA (MCRDHEA) may be involved.	Dehydroepiandrosterone Sulfate	117-122	insulin	Homo sapiens	11-18
9059564-9	1997	When insulin was simultaneously infused once steady-state DHEA levels had been attained, we observed a decline only in DHEA, DHEA-FA and DHEAS levels, with no effect on other steroids examined.	Dehydroepiandrosterone Sulfate	137-142	insulin	Homo sapiens	5-12
9015699-1	1997	Serum concentrations of androstenedione, testosterone and dehydroepiandrosterone sulfate (DHEAS) were measured in 29 patients with premature ovarian failure (POF) and an identical number of age-matched normal control subjects.	Dehydroepiandrosterone Sulfate	58-88	sulfotransferase family 2A member 1	Homo sapiens	90-95
9506315-3	1997	Using a bioassay based on the growing inhibition to Mv-1-Lu cells and RT-PCR analysis, the effect of DHEA and DHEAS on the TGF-beta production and gene expression was studied.	Dehydroepiandrosterone Sulfate	110-115	transforming growth factor, beta 1	Mus musculus	123-131
9008662-10	1997	RESULTS: Baseline levels of serum DHEA sulfate (DHEAS), a stable marker of circulating DHEA levels, were 2 standard deviations below young adult values and increased 3-4 fold within 2 weeks.	Dehydroepiandrosterone Sulfate	34-46	sulfotransferase family 2A member 1	Homo sapiens	48-53
8917605-1	1996	In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS) circulating in blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar range and 30-50% higher in men than in women) decreases with age, toward approximately 20-10% of its value in young adults during the 8th and 9th decades.	Dehydroepiandrosterone Sulfate	31-61	sulfotransferase family 2A member 1	Homo sapiens	63-68
8969933-7	1996	These findings suggest that as children mature there is a decreased level of 3 beta HSD in the adrenal reticularis which may contribute to the increased production of DHEA and DHEAS seen during adrenarche.	Dehydroepiandrosterone Sulfate	176-181	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	77-87
8959647-1	1996	We examined the effect of nicardipine, a calcium antagonist, on the induction of peroxisomal enzymes, such as acyl-CoA oxidase and carnitine acetyltransferase, by dehydroepiandrosterone sulfate (DHEAS) and clofibric acid (CPIB), in primary cultured rat hepatocytes.	Dehydroepiandrosterone Sulfate	195-200	carnitine O-acetyltransferase	Rattus norvegicus	131-158
8956025-1	1996	Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
8959647-2	1996	Peroxisomal beta-oxidation and carnitine acetyltransferase activities were increased 11- and 20-fold, respectively, after 5 days of treatment with DHEAS (40 microM).	Dehydroepiandrosterone Sulfate	147-152	carnitine O-acetyltransferase	Rattus norvegicus	31-58
9014295-2	1996	Improvement in vaccine response has been demonstrated when administering the hormone dehydroepiandrosterone sulfate (DHEAS) as an adjuvant in animal trials.	Dehydroepiandrosterone Sulfate	85-115	sulfotransferase family 2A member 1	Homo sapiens	117-122
8943796-1	1996	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) circulate in the blood mostly bound to albumin but with a small amount not bound to a protein.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
8943798-1	1996	High dehyroepiandrosterone (DHEA) or dehydroepiandrosterone sulphate (DHEAS) levels have been suggested to be protective for cardiovascular disease.	Dehydroepiandrosterone Sulfate	37-68	sulfotransferase family 2A member 1	Homo sapiens	70-75
8886622-1	1996	Recent studies indicate that experimentally induced hyperinsulinemia may reduce serum dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	120-150	sulfotransferase family 2A member 1	Homo sapiens	152-158
8700121-0	1996	Peroxisome proliferator-activated receptor alpha required for gene induction by dehydroepiandrosterone-3 beta-sulfate.	Dehydroepiandrosterone Sulfate	80-117	peroxisome proliferator activated receptor alpha	Mus musculus	0-48
8905477-4	1996	The present study aimed to compare the effect of different HRT on plasma SHBG levels in relationship with the changes of plasma androgen [dehydroepiandrosterone sulphate (DHEAS), testosterone (T), androstenedione (A)] and insulin-like growth factor-1 (IGF-1) levels.	Dehydroepiandrosterone Sulfate	138-169	sex hormone binding globulin	Homo sapiens	73-77
9218249-1	1996	We previously reported that neurosteroids, including dehydroepiandrosterone sulfate (DHEAS), inhibit the production of TNF in vitro and in vivo.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	85-90
9218249-1	1996	We previously reported that neurosteroids, including dehydroepiandrosterone sulfate (DHEAS), inhibit the production of TNF in vitro and in vivo.	Dehydroepiandrosterone Sulfate	53-83	tumor necrosis factor	Homo sapiens	119-122
8930526-7	1996	Serum dehydroepiandrosterone sulfate (DHEA-S) levels of all the patients with ASCA and adrenal Cushing"s syndrome were lower than those of healthy subjects of corresponding age, but they were within the normal range in the patients with non-functional adrenal tumors.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-44
8810735-3	1996	We measured IGF-I, total and free testosterone and dehydroepiandrosterone sulfate (DHEAS) by radioimmunoassays before and 48 and 96 h after the start of the test.	Dehydroepiandrosterone Sulfate	51-81	sulfotransferase family 2A member 1	Homo sapiens	83-88
8669410-4	1996	Energy intake was associated inversely with plasma androstenedione and dehydroepiandrosterone sulfate (DHEAS), averaged across the three menstrual cycle phases, and directly with the probability of a luteal-phase rise in progesterone.	Dehydroepiandrosterone Sulfate	71-101	sulfotransferase family 2A member 1	Homo sapiens	103-108
8765981-2	1996	In this study, serum DHEA and DHEA sulfate (DHEA-S) levels were compared in 50 men with non-insulin-dependent diabetes mellitus (NIDDM) and 50 age-matched men with impaired glucose tolerance (IGT) receiving only diet therapy.	Dehydroepiandrosterone Sulfate	30-42	sulfotransferase family 2A member 1	Homo sapiens	44-50
8809202-3	1996	When administered in combination with histamine (10(-8)-10(-3) M), JP 1-18 (10(-8) or 10(-10) M), enhanced the synthesis of DHEA and DHEAS.	Dehydroepiandrosterone Sulfate	133-138	T cell receptor gamma joining P1	Homo sapiens	67-74
8964884-1	1996	It has been well documented that a significant proportion of chronic anovulatory patients have elevated levels of dehydroepiandrosterone sulfate (DHEAS) and luteinizing hormone (LH) and normal levels of adrenocortiocotropic hormone (ACTH).	Dehydroepiandrosterone Sulfate	114-144	sulfotransferase family 2A member 1	Homo sapiens	146-151
8648259-1	1996	The objective of the study was to relate plasma dehydroepiandrosterone sulfate (DHEA-S) concentrations to the progression of HIV infection in individual HIV-infected men with hemophilia and to obtain information on the cause of DH EA-S alterations.	Dehydroepiandrosterone Sulfate	48-78	sulfotransferase family 2A member 1	Homo sapiens	80-86
9415122-8	1996	The ability of DHEAS treatment to restore normal control over the expression of IL-10 may explain how this steroid enhances immunocompetence in aged animals.	Dehydroepiandrosterone Sulfate	15-20	interleukin 10	Mus musculus	80-85
8626824-0	1996	Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors.	Dehydroepiandrosterone Sulfate	4-34	sulfotransferase family 2A member 1	Homo sapiens	36-42
8626824-1	1996	To assess its differential diagnostic value, dehydroepiandrosterone sulfate (DHEA-S) was measured in a nonselected cohort of 84 patients with incidentally detected adrenal tumors (incidentaloma).	Dehydroepiandrosterone Sulfate	45-75	sulfotransferase family 2A member 1	Homo sapiens	77-83
8724298-1	1996	OBJECTIVE: To determine whether dehydroepiandrosterone sulfate (DHEAS) is linked with soluble immune mediators in systemic lupus erythematosus (SLE).	Dehydroepiandrosterone Sulfate	32-62	sulfotransferase family 2A member 1	Homo sapiens	64-69
8809202-4	1996	JP 1-18, together with histamine, may play a role in the regulation of DHEA and DHEAS production.	Dehydroepiandrosterone Sulfate	80-85	T cell receptor gamma joining P1	Homo sapiens	0-7
9132172-0	1996	Transcriptional induction of Acyl-CoA oxidase by dehydroepiandrosterone sulfate in cultured rat hepatocytes.	Dehydroepiandrosterone Sulfate	49-79	acyl-CoA oxidase 1	Rattus norvegicus	29-45
9132172-1	1996	To elucidate the molecular basis of the induction of peroxisomal enzymes, transcriptional regulation of the acyl-CoA oxidase (AOX) gene by dehydroepiandrosterone sulfate (DHEAS) was examined using primary cultures of rat hepatocytes.	Dehydroepiandrosterone Sulfate	139-169	acyl-CoA oxidase 1	Rattus norvegicus	108-124
9132172-1	1996	To elucidate the molecular basis of the induction of peroxisomal enzymes, transcriptional regulation of the acyl-CoA oxidase (AOX) gene by dehydroepiandrosterone sulfate (DHEAS) was examined using primary cultures of rat hepatocytes.	Dehydroepiandrosterone Sulfate	139-169	acyl-CoA oxidase 1	Rattus norvegicus	126-129
9132172-1	1996	To elucidate the molecular basis of the induction of peroxisomal enzymes, transcriptional regulation of the acyl-CoA oxidase (AOX) gene by dehydroepiandrosterone sulfate (DHEAS) was examined using primary cultures of rat hepatocytes.	Dehydroepiandrosterone Sulfate	171-176	acyl-CoA oxidase 1	Rattus norvegicus	108-124
9132172-1	1996	To elucidate the molecular basis of the induction of peroxisomal enzymes, transcriptional regulation of the acyl-CoA oxidase (AOX) gene by dehydroepiandrosterone sulfate (DHEAS) was examined using primary cultures of rat hepatocytes.	Dehydroepiandrosterone Sulfate	171-176	acyl-CoA oxidase 1	Rattus norvegicus	126-129
9132172-2	1996	Incubation of the hepatocytes with 0.1 mM DHEAS resulted in a progressive increase in the cellular AOX mRNA level, which after 24 h reached a 5.6-fold higher level than that in the control cells treated with vehicle alone.	Dehydroepiandrosterone Sulfate	42-47	acyl-CoA oxidase 1	Rattus norvegicus	99-102
9132172-4	1996	When examined by the nuclear run-on transcription assay, the rate of de novo synthesis of AOX mRNA was 3- to 4-fold higher in the hepatocytes exposed to DHEAS than in the control cells, even after 3h.	Dehydroepiandrosterone Sulfate	153-158	acyl-CoA oxidase 1	Rattus norvegicus	90-93
9132172-5	1996	These results indicate that DHEAS acts directly on hepatocytes to activate the transcription of the AOX gene, which leads to the marked induction of AOX in the cell.	Dehydroepiandrosterone Sulfate	28-33	acyl-CoA oxidase 1	Rattus norvegicus	100-103
9132172-5	1996	These results indicate that DHEAS acts directly on hepatocytes to activate the transcription of the AOX gene, which leads to the marked induction of AOX in the cell.	Dehydroepiandrosterone Sulfate	28-33	acyl-CoA oxidase 1	Rattus norvegicus	149-152
8901021-1	1996	We investigated the effect of two neurosteroids, pregnenolone and dehydroepiandrosterone sulfate on lipopolysaccharide-induced tumor necrosis factor (TNF) production in vivo and in vitro.	Dehydroepiandrosterone Sulfate	66-96	tumor necrosis factor	Homo sapiens	127-148
8901021-1	1996	We investigated the effect of two neurosteroids, pregnenolone and dehydroepiandrosterone sulfate on lipopolysaccharide-induced tumor necrosis factor (TNF) production in vivo and in vitro.	Dehydroepiandrosterone Sulfate	66-96	tumor necrosis factor	Homo sapiens	150-153
8901021-6	1996	administration of dehydroepiandrosterone sulfate (0.2-5 micrograms/mouse) also inhibited brain TNF induced by i.c.v.	Dehydroepiandrosterone Sulfate	18-48	tumor necrosis factor	Mus musculus	95-98
8901021-8	1996	Dehydroepiandrosterone sulfate and pregnenolone (10(-6)-10(-4) M) inhibited TNF production in vitro by lipopolysaccharide-stimulated human peripheral blood mononuclear cells or by the human THP-1 cell line, suggesting that this action might also be relevant in humans.	Dehydroepiandrosterone Sulfate	0-30	tumor necrosis factor	Homo sapiens	76-79
8901021-11	1996	(2) The inhibitory effect of dehydroepiandrosterone sulfate and pregnenolone on TNF production was not reversed by the glucocorticoid receptor antagonist, mifepristone (RU38486).	Dehydroepiandrosterone Sulfate	29-59	tumor necrosis factor	Homo sapiens	80-83
8795709-3	1996	This study was designed to determine whether dioscorea supplementation could increase serum dehydroepiandrosterone sulfate (DHEAS) in humans and modulate lipid levels in older people.	Dehydroepiandrosterone Sulfate	92-122	sulfotransferase family 2A member 1	Homo sapiens	124-129
8772596-0	1996	The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old.	Dehydroepiandrosterone Sulfate	20-50	sulfotransferase family 2A member 1	Homo sapiens	52-57
8772596-2	1996	Dehydroepiandrosterone sulfate (DHEAS), the major circulating adrenal hormone, has been suggested to have a role in many aging related diseases and perhaps in aging itself.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
8740936-7	1996	There were significant positive correlations between the CD4 cell count and the serum concentrations of DHEAs (p &lt; 0.0001), DHEA (p &lt; 0.01) and E1 (p &lt; 0.006).	Dehydroepiandrosterone Sulfate	104-109	CD4 molecule	Homo sapiens	57-60
8938473-0	1996	Dehydroepiandrosterone sulfate potentiates the effect of interleukin-8 on the cervix.	Dehydroepiandrosterone Sulfate	0-30	interleukin-8	Oryctolagus cuniculus	57-70
8938473-4	1996	The aim of this research was to study the effect of DHA-S on the function of IL-8 on the cervix.	Dehydroepiandrosterone Sulfate	52-57	interleukin-8	Oryctolagus cuniculus	77-81
8938473-10	1996	A maximal decrease in collagen content was found in the DHA-S + IL-8-treated group (71.5%).	Dehydroepiandrosterone Sulfate	56-61	interleukin-8	Oryctolagus cuniculus	64-68
8938473-11	1996	Neutrophil infiltration was significantly increased in the IL-8 and DHA-S + IL-8-treated groups (p &lt; 0.0001).	Dehydroepiandrosterone Sulfate	68-73	interleukin-8	Oryctolagus cuniculus	76-80
8938473-16	1996	DHA-S has a synergistic effect with IL-8 during cervical ripening.	Dehydroepiandrosterone Sulfate	0-5	interleukin-8	Oryctolagus cuniculus	36-40
8550794-1	1996	Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) levels were determined in morning specimens from 659 fasting postmenopausal women who were not using estrogen therapy or antidiabetic medication.	Dehydroepiandrosterone Sulfate	34-64	sulfotransferase family 2A member 1	Homo sapiens	66-71
8597464-1	1995	In 1986 we reported that high levels of plasma dehydroepiandrosterone sulfate (DHEAS) reduced the risk of fatal cardiovascular disease (CVD) in 242 men and increased the risk in 289 women from the Rancho Bernardo cohort who were followed up for 12 years.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-84
8597466-1	1995	The hypothesis has been advanced that the adrenal steroids dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) exert antiatherogenic and cardioprotective actions.	Dehydroepiandrosterone Sulfate	93-105	sulfotransferase family 2A member 1	Homo sapiens	107-112
7498969-3	1995	DHEAS produced a significant, dose-dependent relaxation of isolated helical strips of rat tail artery precontracted with KCl (60 mmol/L) (89.7 +/- 18.7%, P &lt; .01), arginine vasopressin (3 nmol/L) (27.3 +/- 7.1%, P &lt; .01), and norepinephrine (0.1 mumol/L) (49.2 +/- 18.2%, P &lt; .01).	Dehydroepiandrosterone Sulfate	0-5	arginine vasopressin	Rattus norvegicus	176-187
8751327-1	1995	Dehydroepiandrosterone sulfotransferase (DHEA-ST) catalyzes the conversion of dehydroepiandrosterone (DHEA) to dehydroepiandrosterone sulfate (DHEA-S) in the adrenals.	Dehydroepiandrosterone Sulfate	111-141	sulfotransferase family 2A member 1	Homo sapiens	0-39
8751327-1	1995	Dehydroepiandrosterone sulfotransferase (DHEA-ST) catalyzes the conversion of dehydroepiandrosterone (DHEA) to dehydroepiandrosterone sulfate (DHEA-S) in the adrenals.	Dehydroepiandrosterone Sulfate	111-141	sulfotransferase family 2A member 1	Homo sapiens	41-48
7665693-5	1995	The KS+ patients with more than 500 CD4 lymphocytes per mm3 had significantly higher serum DHEA, DHEA sulphate, and testosterone than the KS- patients with the same CD4 counts; those with 500-200 CD4 cells/mm3 had higher serum DHEA and testosterone than the equivalent KS- men; and those with &lt; 200 CD4 cells/mm3 had raised DHEA only compared with KS- men.	Dehydroepiandrosterone Sulfate	97-110	CD4 molecule	Homo sapiens	36-39
7593454-9	1995	Hence, dietary weight loss accompanied by equivalent reductions in body mass index and serum insulin between sexes was associated with a marked rise in serum DHEA-sulfate in men, whereas in women serum DHEA-sulfate did not change.	Dehydroepiandrosterone Sulfate	158-170	insulin	Homo sapiens	93-100
7593454-10	1995	Although speculative, these findings are consistent with the idea that insulin acts in a sex-specific fashion to reduce circulating DHEA-sulfate in men only.	Dehydroepiandrosterone Sulfate	132-144	insulin	Homo sapiens	71-78
7586621-1	1995	OBJECTIVE: As part of a study on the effect of dopamine therapy on pituitary dependent hormone secretion in critical illness, we documented the impact of this inotropic and vasoactive catecholamine on the serum concentrations of dehydroepiandrosterone sulphate (DHEAS).	Dehydroepiandrosterone Sulfate	229-260	sulfotransferase family 2A member 1	Homo sapiens	262-267
7675372-7	1995	The PCOS subjects exhibited a significant positive correlation between the upper-half/lower-half body fat ratio and dehydroepiandrosterone-sulfate (DHEA-S) levels (r = 0.607, P &lt; .01) as well as testosterone levels (r = 0.585, P &lt; .05).	Dehydroepiandrosterone Sulfate	116-146	sulfotransferase family 2A member 1	Homo sapiens	148-154
12506415-8	1995	A slight, although significant (P &lt; 0.05), enhancement of serum dehydroepiandrosterone sulfate (DHEAS) level was found after the injection of 0.3 microgram/g desacetyl-alpha-MSH, whereas both the 0.3 and 3 micrograms/g doses of desacetyl-alpha-MSH and the 3 micrograms/g dose of alpha-MSH determined the rise of plasma androstenedione (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	67-97	proopiomelanocortin	Rattus norvegicus	171-180
12506415-8	1995	A slight, although significant (P &lt; 0.05), enhancement of serum dehydroepiandrosterone sulfate (DHEAS) level was found after the injection of 0.3 microgram/g desacetyl-alpha-MSH, whereas both the 0.3 and 3 micrograms/g doses of desacetyl-alpha-MSH and the 3 micrograms/g dose of alpha-MSH determined the rise of plasma androstenedione (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	99-104	proopiomelanocortin	Rattus norvegicus	171-180
12506415-8	1995	A slight, although significant (P &lt; 0.05), enhancement of serum dehydroepiandrosterone sulfate (DHEAS) level was found after the injection of 0.3 microgram/g desacetyl-alpha-MSH, whereas both the 0.3 and 3 micrograms/g doses of desacetyl-alpha-MSH and the 3 micrograms/g dose of alpha-MSH determined the rise of plasma androstenedione (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	99-104	proopiomelanocortin	Rattus norvegicus	241-250
12506415-8	1995	A slight, although significant (P &lt; 0.05), enhancement of serum dehydroepiandrosterone sulfate (DHEAS) level was found after the injection of 0.3 microgram/g desacetyl-alpha-MSH, whereas both the 0.3 and 3 micrograms/g doses of desacetyl-alpha-MSH and the 3 micrograms/g dose of alpha-MSH determined the rise of plasma androstenedione (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	99-104	proopiomelanocortin	Rattus norvegicus	241-250
7588424-1	1995	Dehydroepiandrosterone sulfate (DHEAS) concentration levels were measured by a specific RIA in 23 female and 7 male patients with classical congenital adrenal hyperplasia (CAH) salt-losing type due to steroid 21-hydroxylase (21-OH) deficiency.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
8525387-4	1995	DATA EXTRACTION: Mean (+/- SD) serum levels of dehydroepiandrosterone sulfate (DHEAS), testosterone (T), and estradiol (E2).	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-84
7674231-5	1995	A statistically significant correlation was observed between changes of IGF-I levels and of dehydroepiandrosterone sulphate (DHEAS).	Dehydroepiandrosterone Sulfate	92-123	insulin like growth factor 1	Homo sapiens	72-77
7674231-5	1995	A statistically significant correlation was observed between changes of IGF-I levels and of dehydroepiandrosterone sulphate (DHEAS).	Dehydroepiandrosterone Sulfate	125-130	insulin like growth factor 1	Homo sapiens	72-77
7554562-0	1995	Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/pemphigus and psoriasis.	Dehydroepiandrosterone Sulfate	6-37	sulfotransferase family 2A member 1	Homo sapiens	39-44
7621563-6	1995	MEASUREMENTS: Circulating levels of dehydroepiandrosterone sulphate (DHEAS), were determined as an indicator of adrenarche.	Dehydroepiandrosterone Sulfate	36-67	sulfotransferase family 2A member 1	Homo sapiens	69-74
7615347-2	1995	The extension of glial fibrillary acidic protein (GFAP)-immunoreactive astroglial cell processes was assessed in hippocampal slice cultures from adult gonadectomized male rats under the influence of the neurosteroids dehydroepiandrosterone, dehydroepiandrosterone sulfate, dehydroepiandrosterone estereate, pregnenolone, pregnenolone sulfate, and pregnenolone oleate.	Dehydroepiandrosterone Sulfate	241-271	glial fibrillary acidic protein	Rattus norvegicus	50-54
7738486-10	1995	A negative correlation between fasting insulin and the plasma levels of DHEA-S was established.	Dehydroepiandrosterone Sulfate	72-78	insulin	Homo sapiens	39-46
7962271-6	1994	Whatever the experimental condition, TGF beta 1 did not reduce basal or ACTH-stimulated cortisol production, but the production of dehydroepiandrosterone sulfate of TGF beta 1-treated cells was always decreased.	Dehydroepiandrosterone Sulfate	131-161	transforming growth factor beta 1	Homo sapiens	165-175
7589785-2	1995	The enzyme in the adrenal responsible for synthesising DHEAS, hydroxysteroid sulphotransferase (HST), is therefore essential for human development.	Dehydroepiandrosterone Sulfate	55-60	sulfotransferase family 2A member 1	Homo sapiens	62-94
7589785-2	1995	The enzyme in the adrenal responsible for synthesising DHEAS, hydroxysteroid sulphotransferase (HST), is therefore essential for human development.	Dehydroepiandrosterone Sulfate	55-60	sulfotransferase family 2A member 1	Homo sapiens	96-99
7859374-6	1995	N-OH-ABP sulfotransferase activity was highly sensitive to inhibition by a selective TS-PST inhibitor, 2,6-dichloro-4-nitrophenol (IC50 = 0.7 microM), and by p-nitrophenol, but was unaffected by competitive inhibitors of TL-PST (dopamine) or DHEA-ST (DHEA, DHEA-sulfate).	Dehydroepiandrosterone Sulfate	257-269	sulfotransferase family 1A member 2	Homo sapiens	85-91
7704956-1	1995	BACKGROUND AND OBJECTIVE: Reduced serum levels of dehydroepiandrosterone sulphate (DHEAS) have been shown in patients with Cushing"s syndrome resulting from adrenocortical adenoma, in contrast with normal DHEAS levels in patients with Cushing"s disease.	Dehydroepiandrosterone Sulfate	50-81	sulfotransferase family 2A member 1	Homo sapiens	83-88
7873450-6	1995	Interestingly, 10-1000 nM dehydroepiandrosterone (DHEA) and 1-10 microM DHEA-sulfate rapidly reduced the steady-state level of c-fos mRNA by 60-80% in a dose-dependent manner within 30 min.	Dehydroepiandrosterone Sulfate	72-84	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	127-132
7873450-9	1995	This increase in TGF-beta activity by DHEA-sulfate was both time- and dose-dependent, and was not blocked by cotreatment with the specific aromatase inhibitor 4-hydroxyandrostenedione (1 microM).	Dehydroepiandrosterone Sulfate	38-50	transforming growth factor beta 1	Homo sapiens	17-25
7873450-10	1995	Immunoprecipitations of the hOB cell conditioned-media with isoform-specific TGF-beta neutralizing-antibodies indicated that TGF-beta 2 was predominantly produced by the cells in response to DHEA-sulfate treatment.	Dehydroepiandrosterone Sulfate	191-203	transforming growth factor beta 1	Homo sapiens	77-85
7873450-10	1995	Immunoprecipitations of the hOB cell conditioned-media with isoform-specific TGF-beta neutralizing-antibodies indicated that TGF-beta 2 was predominantly produced by the cells in response to DHEA-sulfate treatment.	Dehydroepiandrosterone Sulfate	191-203	transforming growth factor beta 2	Homo sapiens	125-135
7873450-12	1995	Moreover, these data suggest that DHEA and DHEA-sulfate may play a distinct role in the regulation of human osteoblast function via the rapid repression of c-fos message levels and the slower increase in TGF-beta 2 protein levels.	Dehydroepiandrosterone Sulfate	43-55	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	156-161
7873450-12	1995	Moreover, these data suggest that DHEA and DHEA-sulfate may play a distinct role in the regulation of human osteoblast function via the rapid repression of c-fos message levels and the slower increase in TGF-beta 2 protein levels.	Dehydroepiandrosterone Sulfate	43-55	transforming growth factor beta 2	Homo sapiens	204-214
7618186-0	1995	Re-examination of the effect of hCG on plasma levels and renal excretion of dehydroepiandrosterone sulfate in healthy males.	Dehydroepiandrosterone Sulfate	76-106	hypertrichosis 2 (generalised, congenital)	Homo sapiens	32-35
7618186-4	1995	Contrary to previous findings in normal men, the present study revealed significant DHEAS responses after testicular stimulation with hCG: plasma DHEAS increased from 7.9 +/- 2.3 to 9.6 +/- 2.2 mumol/L (P &lt; 0.05) and urinary DHEAS from 5.7 +/- 3.6 to 9.3 +/- 5.2 mumol/day (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	84-89	hypertrichosis 2 (generalised, congenital)	Homo sapiens	134-137
7618186-4	1995	Contrary to previous findings in normal men, the present study revealed significant DHEAS responses after testicular stimulation with hCG: plasma DHEAS increased from 7.9 +/- 2.3 to 9.6 +/- 2.2 mumol/L (P &lt; 0.05) and urinary DHEAS from 5.7 +/- 3.6 to 9.3 +/- 5.2 mumol/day (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	146-151	hypertrichosis 2 (generalised, congenital)	Homo sapiens	134-137
7618186-4	1995	Contrary to previous findings in normal men, the present study revealed significant DHEAS responses after testicular stimulation with hCG: plasma DHEAS increased from 7.9 +/- 2.3 to 9.6 +/- 2.2 mumol/L (P &lt; 0.05) and urinary DHEAS from 5.7 +/- 3.6 to 9.3 +/- 5.2 mumol/day (P &lt; 0.05).	Dehydroepiandrosterone Sulfate	146-151	hypertrichosis 2 (generalised, congenital)	Homo sapiens	134-137
7618186-8	1995	Significant correlations were found for the post-hCG percent increases of plasma androstenedione versus plasma DHEAS (r = 0.86) and for the percent increases of plasma testosterone versus urinary DHEAS (r = 0.98), indicating that the extent of gonadal androgen elevations in the circulation of normal men is a determinant of DHEAS increases in blood or urine.	Dehydroepiandrosterone Sulfate	111-116	hypertrichosis 2 (generalised, congenital)	Homo sapiens	49-52
8578930-2	1995	To study the possible relationship between bone density and serum levels of dehydroepiandrosterone sulphate (DHEAS) we investigated 105 women (45-69 years).	Dehydroepiandrosterone Sulfate	76-107	sulfotransferase family 2A member 1	Homo sapiens	109-114
8555732-6	1995	The simultaneous increase of serum insulin, free-T and DHEAS coinciding with a cortisol decrease may enhance insulin anabolic effects following breakfast, but not after oral glucose alone.	Dehydroepiandrosterone Sulfate	55-60	insulin	Homo sapiens	109-116
7749143-2	1995	In humans, very high levels of DHEA and/or dehydroepiandrosterone sulfate (DHEAS) have been found in breast tissues and secretions, and epidemiological studies suggest a role of these steroids in the modulation of breast cancer growth.	Dehydroepiandrosterone Sulfate	43-73	sulfotransferase family 2A member 1	Homo sapiens	75-80
7829645-4	1995	To investigate the mechanism of hypocholesterolemia in this case, we examined the effects of dehydroepiandrosterone and dehydroepiandrosterone sulfate on the low density lipoprotein (LDL) receptor activity of fibroblasts.	Dehydroepiandrosterone Sulfate	120-150	low density lipoprotein receptor	Homo sapiens	158-196
8904474-11	1995	However, an inverse correlation between fetal plasma CRH and DHEAS levels was found (r = -0.41, p &lt; 0.001).	Dehydroepiandrosterone Sulfate	61-66	corticotropin releasing hormone	Homo sapiens	53-56
8904474-14	1995	We hypothesize that continuous stimulation of the pituitary and adrenal by circulating CRH during development may occur and the inverse correlation between fetal plasma CRH and DHEAS may be due to this chronic regulatory effect.	Dehydroepiandrosterone Sulfate	177-182	corticotropin releasing hormone	Homo sapiens	169-172
7989452-3	1994	The most frequent finding was the reduction of dehydroepiandrosterone sulfate (DHEA-S) levels below the third percentile of controls in 19 (42%) pts.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-85
7895901-3	1994	ACTH treatment enhanced the secretion of cortisol and to a lesser extent that of DHAS, and increased the steroidogenic response to an acute stimulation with ACTH.	Dehydroepiandrosterone Sulfate	81-85	proopiomelanocortin	Homo sapiens	0-4
7895901-5	1994	A-II treatment also increased the secretion of both DHAS and cortisol, but less than ACTH, enhanced the responsiveness to ACTH and increased ACTHR, P450scc and P450 17 alpha mRNA levels.	Dehydroepiandrosterone Sulfate	52-56	angiotensinogen	Homo sapiens	0-4
7895901-6	1994	In contrast, TGF beta 1 alone or together with ACTH decreased DHAS secretion, but not cortisol secretion.	Dehydroepiandrosterone Sulfate	62-66	transforming growth factor beta 1	Homo sapiens	13-23
7895901-6	1994	In contrast, TGF beta 1 alone or together with ACTH decreased DHAS secretion, but not cortisol secretion.	Dehydroepiandrosterone Sulfate	62-66	proopiomelanocortin	Homo sapiens	47-51
7977274-1	1994	High levels of dehydroepiandrosterone sulfate (DHEAS) have been associated with decreased risks of cardiovascular disease.	Dehydroepiandrosterone Sulfate	15-45	sulfotransferase family 2A member 1	Homo sapiens	47-52
7955606-0	1994	Blood dehydroepiandrosterone sulphate (DHEAS) levels in polymyalgia rheumatica/giant cell arteritis and primary fibromyalgia.	Dehydroepiandrosterone Sulfate	6-37	sulfotransferase family 2A member 1	Homo sapiens	39-44
7955606-1	1994	Blood levels of dehydroepiandrosterone sulphate (DHEAS) were measured by radioimmunoassay (RIA) in patients with: a) polymyalgia rheumatica/giant cell arteritis (PMR:TA; N = 25), with and without cortisone derivative treatment (N = 10 and N = 15, respectively); and b) primary fibromyalgia (PF; N = 15).	Dehydroepiandrosterone Sulfate	16-47	sulfotransferase family 2A member 1	Homo sapiens	49-54
7882484-2	1995	BACKGROUND: High levels of dehydroepiandrosterone sulfate (DHEAS) appear to be associated with a reduced risk of fatal cardiovascular disease (CVD) in men.	Dehydroepiandrosterone Sulfate	27-57	sulfotransferase family 2A member 1	Homo sapiens	59-64
7955120-1	1994	Dehydroepiandrosterone sulfate (DHEAS) is the most abundant adrenal steroid with apparent anticarcinogenic properties.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
7962276-2	1994	The present study was conducted to determine whether 1) the nondihydropyridine calcium channel blocker diltiazem also reduces circulating insulin levels in humans, and 2) a reduction in circulating insulin with a calcium channel blocker is associated with a rise in serum DHEA-S concentrations in women as well as men.	Dehydroepiandrosterone Sulfate	272-278	insulin	Homo sapiens	198-205
7962276-7	1994	In men, concurrent with the fall in serum insulin levels, serum DHEA-S levels rose from 4.05 +/- 1.06 to 6.91 +/- 1.32 mumol/L (P &lt; 0.04), and serum DHEA levels rose from 14.4 +/- 3.0 to 24.3 +/- 4.6 nmol/L (P = 0.05) with diltiazem treatment, whereas serum cortisol did not change.	Dehydroepiandrosterone Sulfate	64-70	insulin	Homo sapiens	42-49
7799892-1	1994	UNLABELLED: Studies on animals and humans have suggested that dehydroepiandrosterone sulphate (DHEAS) has antiatherogenic effects.	Dehydroepiandrosterone Sulfate	62-93	sulfotransferase family 2A member 1	Homo sapiens	95-100
7962271-7	1994	The effects of TGF beta 1 on 3 beta-hydroxysteroid dehydrogenase mRNA and dehydroepiandrosterone sulfate were opposite the change observed at the time of adrenarche.	Dehydroepiandrosterone Sulfate	74-104	transforming growth factor beta 1	Homo sapiens	15-25
7962276-1	1994	Evidence suggests that amelioration of hyperinsulinemic insulin resistance in men with calcium channel blockers of the dihydropyridine class is associated with a fall in serum insulin and a rise in serum dehydroepiandrosterone sulfate (DHEA-S) concentrations.	Dehydroepiandrosterone Sulfate	204-234	insulin	Homo sapiens	44-51
7962276-1	1994	Evidence suggests that amelioration of hyperinsulinemic insulin resistance in men with calcium channel blockers of the dihydropyridine class is associated with a fall in serum insulin and a rise in serum dehydroepiandrosterone sulfate (DHEA-S) concentrations.	Dehydroepiandrosterone Sulfate	236-242	insulin	Homo sapiens	44-51
8010622-0	1994	Dehydroepiandrosterone sulphate (DHEAS) in the oldest old, aged 85 and over.	Dehydroepiandrosterone Sulfate	0-31	sulfotransferase family 2A member 1	Homo sapiens	33-38
7927194-2	1994	The purpose of the present study was to determine if plasma testosterone (T), sex hormone-binding globulin (SHBG), and dehydroepiandrosterone sulfate (DHEAS) concentration were altered with an exercise training program which reduced CAD risk.	Dehydroepiandrosterone Sulfate	119-149	sulfotransferase family 2A member 1	Homo sapiens	151-156
7515387-14	1994	In conclusion, restoring DHEA and DS to young adult levels in men and women of advancing age induced an increase in the bioavailability of IGF-I, as reflected by an increase in IGF-I and a decrease in IGFBP-1 levels.	Dehydroepiandrosterone Sulfate	34-36	insulin like growth factor 1	Homo sapiens	139-144
7515387-14	1994	In conclusion, restoring DHEA and DS to young adult levels in men and women of advancing age induced an increase in the bioavailability of IGF-I, as reflected by an increase in IGF-I and a decrease in IGFBP-1 levels.	Dehydroepiandrosterone Sulfate	34-36	insulin like growth factor 1	Homo sapiens	177-182
8144828-1	1994	OBJECTIVE: To determine whether low plasma dehydroepiandrosterone sulfate (DHEAS) levels predict poor cognitive function in the elderly.	Dehydroepiandrosterone Sulfate	43-73	sulfotransferase family 2A member 1	Homo sapiens	75-80
8040843-5	1994	It is hypothesized that adrenal dehydroepiandrosterone sulfate may modify the effects of insulin resistance, as reflected in androgen and apolipoprotein lipid metabolism.	Dehydroepiandrosterone Sulfate	32-62	insulin	Homo sapiens	89-96
8274430-13	1993	The higher level of 3 beta-HSD mRNA in definitive zone compared with fetal zone cells was associated with parallel increases in cortisol secretion relative to dehydroepiandrosterone sulfate formation.	Dehydroepiandrosterone Sulfate	159-189	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	20-30
8137159-0	1994	Dehydroepiandrosterone sulfate alters synaptic potentials in area CA1 of the hippocampal slice.	Dehydroepiandrosterone Sulfate	0-30	carbonic anhydrase 1	Homo sapiens	66-69
8274474-4	1994	We examined the possible associations of sex hormone-binding globulin, total and free testosterone, estradiol, and dehydroepiandrosterone sulfate to Lp(a) concentrations in men in two population-based studies (San Antonio Heart Study [n = 178] and a Finnish study on the association between insulin resistance and atherosclerosis [n = 87]).	Dehydroepiandrosterone Sulfate	115-145	lipoprotein(a)	Homo sapiens	149-154
8293546-10	1994	ST activity towards dopamine was low with both hHSTs, but hHST1 also contained significant capacity to sulfate dehydroepiandrosterone.	Dehydroepiandrosterone Sulfate	103-133	fibroblast growth factor 4	Homo sapiens	58-63
9419751-2	1994	METHODS: Five insulin-resistant women diagnosed as having polycystic ovaries (PCO) with elevated testosterone and normal dehydroepiandrosterone sulfate (DHEAS) with amenorrhea were recruited.	Dehydroepiandrosterone Sulfate	121-151	insulin	Homo sapiens	14-21
7997146-7	1994	The concentrations of estrone (p &lt; 0.01), estradiol, progesterone, 17-hydroxy-progesterone, testosterone and dehydroepiandrosterone sulphate (DHAS) were significantly decreased in women chronically exposed to CS2 (p &lt; 0.001).	Dehydroepiandrosterone Sulfate	112-143	chorionic somatomammotropin hormone 2	Homo sapiens	212-215
8003324-6	1994	In hirsutism the percentages of S phase cells ran parallel to the plasma levels of dehydroepiandrosterone sulfate whereas no correlation to testosterone could be proved.	Dehydroepiandrosterone Sulfate	83-113	RAN, member RAS oncogene family	Homo sapiens	46-49
8140596-2	1994	A commercial 125I radioimmunoassay designed for the quantification of dehydroepiandrosterone sulfate (DHEAS) in blood samples was tested for its direct applicability to 24-hour urine samples from children and adults.	Dehydroepiandrosterone Sulfate	70-100	sulfotransferase family 2A member 1	Homo sapiens	102-107
8242561-3	1993	Plasma cortisol, serum testosterone, and dehydroepiandrosterone sulfate (DHEA-S) levels were increased to 34.1 micrograms/dl, 2.0 ng/ml, and 6.628 ng/ml, respectively.	Dehydroepiandrosterone Sulfate	41-71	sulfotransferase family 2A member 1	Homo sapiens	73-79
8126125-0	1994	Effects of a reduction in circulating insulin by metformin on serum dehydroepiandrosterone sulfate in nondiabetic men.	Dehydroepiandrosterone Sulfate	68-98	insulin	Homo sapiens	38-45
8126125-8	1994	When the results from both groups were combined, changes in serum DHEA sulfate levels (i.e. day 21 value minus day 0 value) correlated positively with baseline fasting serum insulin levels (r = 0.44; P = 0.02; n = 28).	Dehydroepiandrosterone Sulfate	66-78	insulin	Homo sapiens	174-181
8126125-9	1994	Moreover, changes in fasting serum DHEA sulfate levels correlated inversely with changes in fasting serum insulin levels (r = -0.38; P &lt; 0.05; n = 28).	Dehydroepiandrosterone Sulfate	35-47	insulin	Homo sapiens	106-113
8126125-10	1994	These findings lend further credence to the idea that insulin acts as a physiological regulator of DHEA sulfate metabolism and lowers circulating DHEA sulfate concentrations in men.	Dehydroepiandrosterone Sulfate	99-111	insulin	Homo sapiens	54-61
8126125-10	1994	These findings lend further credence to the idea that insulin acts as a physiological regulator of DHEA sulfate metabolism and lowers circulating DHEA sulfate concentrations in men.	Dehydroepiandrosterone Sulfate	146-158	insulin	Homo sapiens	54-61
8206321-3	1994	Inhibition of basal dehydroepiandrosterone sulfate (DS) production usually was noted only after 3 or more days of treatment with &gt; or = 0.1 ng TGF-beta/ml.	Dehydroepiandrosterone Sulfate	20-50	transforming growth factor beta 1	Homo sapiens	146-154
8206321-3	1994	Inhibition of basal dehydroepiandrosterone sulfate (DS) production usually was noted only after 3 or more days of treatment with &gt; or = 0.1 ng TGF-beta/ml.	Dehydroepiandrosterone Sulfate	52-54	transforming growth factor beta 1	Homo sapiens	146-154
8206321-7	1994	These results are suggestive that TGF-beta differentially inhibits DS and cortisol production by human fetal adrenal cells and that the site of TGF-beta action on steroidogenesis may be distal to the generation of cAMP.	Dehydroepiandrosterone Sulfate	67-69	transforming growth factor beta 1	Homo sapiens	34-42
8003845-2	1994	To study the possible relationship between bone density and serum levels of dehydroepiandrosterone sulphate (DHEAS) we investigated 105 women (aged 45-69 years; 76 postmenopausal, 29 perimenopausal).	Dehydroepiandrosterone Sulfate	76-107	sulfotransferase family 2A member 1	Homo sapiens	109-114
8169562-10	1994	In the presence of ACTH, dehydroepiandrosterone sulphate secretion remained elevated throughout the entire study up to 5 days.	Dehydroepiandrosterone Sulfate	25-56	proopiomelanocortin	Homo sapiens	19-23
8169562-12	1994	In the presence of ACTH, dibutyryl cyclic AMP or cholera toxin the secretion of dehydroepiandrosterone sulphate, androstenedione and 11-desoxycortisol increased markedly with time in culture up to 3 days, whereas the other steroids were undetected in the medium.	Dehydroepiandrosterone Sulfate	80-111	proopiomelanocortin	Homo sapiens	19-23
8022098-2	1994	Stress stimulates the secretion of two adrenal hormones, cortisol and dehydroepiandrosterone-sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	70-100	sulfotransferase family 2A member 1	Homo sapiens	102-108
8299250-1	1993	To assess the relationship between blood and tissue steroid levels, cortisol and dehydroepiandrosterone sulphate (DHEAS) were measured by radioimmunoassay (RIA) in blood and joint tissues from a group of patients with RA (N = 29) ranging in age from 26 to 80 years (mean 63, SD: 13) and another group with secondary osteoarthritis (OA; N = 23), ranging in age from 47 to 86 years (mean 66, SD: 9), all of whom were scheduled for surgical correction of joint dysfunction.	Dehydroepiandrosterone Sulfate	81-112	sulfotransferase family 2A member 1	Homo sapiens	114-119
8404664-6	1993	ANF, BNP, and CNP stimulated the production of intermediate precursors of testosterone biosynthesis, which included progesterone, 17 alpha-hydroxy progesterone, androstenedione, pregnenolone, 17 alpha-hydroxy pregnenolone, and dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	227-257	natriuretic peptide type A	Mus musculus	0-3
8404664-6	1993	ANF, BNP, and CNP stimulated the production of intermediate precursors of testosterone biosynthesis, which included progesterone, 17 alpha-hydroxy progesterone, androstenedione, pregnenolone, 17 alpha-hydroxy pregnenolone, and dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	227-257	natriuretic peptide type C	Mus musculus	14-17
8404664-6	1993	ANF, BNP, and CNP stimulated the production of intermediate precursors of testosterone biosynthesis, which included progesterone, 17 alpha-hydroxy progesterone, androstenedione, pregnenolone, 17 alpha-hydroxy pregnenolone, and dehydroepiandrosterone sulfate.	Dehydroepiandrosterone Sulfate	227-257	natriuretic peptide type B	Mus musculus	5-8
8396578-0	1993	Interaction of insulin-like growth factor-II and estradiol directs steroidogenesis in the human fetal adrenal toward dehydroepiandrosterone sulfate production.	Dehydroepiandrosterone Sulfate	117-147	insulin like growth factor 2	Homo sapiens	15-44
8412740-1	1993	Dehydroepiandrosterone sulfate (DHEAS) was examined in random (control) and nonrandom (case) families participating in the Cincinnati Myocardial Infarction and Hormone (CIMIH) family study.	Dehydroepiandrosterone Sulfate	0-30	sulfotransferase family 2A member 1	Homo sapiens	32-37
8396578-3	1993	Our underlying hypothesis is that estrogen and insulin-like growth factor-II (IGF-II) modulate the steroidogenic response of fetal zone cells to ACTH, driving steroid production toward DHAS rather than cortisol.	Dehydroepiandrosterone Sulfate	185-189	insulin like growth factor 2	Homo sapiens	47-84
8396578-7	1993	IGF-II increased ACTH-stimulated cortisol and DHAS secretion by fetal zone cells in a dose-dependent fashion.	Dehydroepiandrosterone Sulfate	46-50	insulin like growth factor 2	Homo sapiens	0-6
8396578-9	1993	Combinations of IGF-II (100 ng/mL) and E2 (1 mumol/L) increased ACTH-stimulated cortisol and DHAS secretion by 1.5- to 2-fold compared with control values.	Dehydroepiandrosterone Sulfate	93-97	insulin like growth factor 2	Homo sapiens	16-22
8401752-2	1993	The present study was undertaken to evaluate the possibility of a relationship between the circulating levels of IGF-1 and those of dehydroepiandrosterone sulphate (DHEAS) in 25 fertile obese women.	Dehydroepiandrosterone Sulfate	132-163	insulin like growth factor 1	Homo sapiens	113-118
8401752-2	1993	The present study was undertaken to evaluate the possibility of a relationship between the circulating levels of IGF-1 and those of dehydroepiandrosterone sulphate (DHEAS) in 25 fertile obese women.	Dehydroepiandrosterone Sulfate	132-163	sulfotransferase family 2A member 1	Homo sapiens	165-170
8664166-8	1993	PAP seemed the more pathological marker; PSA was somewhat anticorrelated to the adrenal androgen (DHA and DS) and PREG levels.	Dehydroepiandrosterone Sulfate	106-108	kallikrein related peptidase 3	Homo sapiens	41-44
8334152-3	1993	Among the steroids examined, DHEA, DHEA sulfate (DHEAS), dehydroandrosterone sulfate, androstenediol 3-sulfate, epiandrosterone sulfate and androsterone sulfate significantly induced the enzymes; 4.6- to 14.2-fold for beta-oxidation and 5.1- to 10.9-fold for carnitine acetyltransferase at 50 microM.	Dehydroepiandrosterone Sulfate	57-84	carnitine O-acetyltransferase	Rattus norvegicus	259-286
8452124-0	1993	A prospective study of dehydroepiandrosterone sulfate (DHEAS) and bone mineral density in older men and women.	Dehydroepiandrosterone Sulfate	23-53	sulfotransferase family 2A member 1	Homo sapiens	55-60
8403905-3	1993	Regression analyses showed that PRL levels were independent of the other parameters, while a negative correlation was found between DHEA-S and SBP values.	Dehydroepiandrosterone Sulfate	132-138	selenium binding protein 1	Homo sapiens	143-146
8515056-6	1993	In aged mice, the reduced regulation of IL-6 production could be effectively prevented and/or reversed by supplementing aging animals with dehydroepiandrosterone sulfate, a steroid hormone whose endogenous production is known to decline with advancing age in all species tested.	Dehydroepiandrosterone Sulfate	139-169	interleukin 6	Mus musculus	40-44
8318873-1	1993	Levels of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) in sera collected and frozen in 1974 were studied among 81 prostate cancer cases diagnosed in the following 12 years and 81 age- and race-matched controls.	Dehydroepiandrosterone Sulfate	44-74	sulfotransferase family 2A member 1	Homo sapiens	76-82
8388710-6	1993	The steroid sulfates (pregnenolone sulfate and dehydroepiandrosterone sulfate) on the other hand, act as competitive inhibitors with Kis ranging from 4 to 6 microM.	Dehydroepiandrosterone Sulfate	47-77	U2AF homology motif kinase 1	Homo sapiens	133-136
8473406-2	1993	In women, ADTG levels reflect essentially adrenal androgen secretion, dehydroepiandrosterone sulfate (DHEAS) being the major precursor, accounting for 70%-80% of ADTG levels.	Dehydroepiandrosterone Sulfate	70-100	sulfotransferase family 2A member 1	Homo sapiens	102-107
8093989-5	1993	The purpose of this study is to investigate whether dehydroepiandrosterone-sulphate (DHEA-S) or cortisol levels correlate with absolute CD4 lymphocyte levels.	Dehydroepiandrosterone Sulfate	52-83	sulfotransferase family 2A member 1	Homo sapiens	85-91
8452124-1	1993	The purpose of this study was to prospectively examine the relation of dehydroepiandrosterone sulfate (DHEAS) to bone mineral density in a community-based sample of 260 men and 162 women who were residents of Rancho Bernardo, California.	Dehydroepiandrosterone Sulfate	71-101	sulfotransferase family 2A member 1	Homo sapiens	103-108
8307110-0	1993	Chronic insulin treatment, but not chronic ACTH administration increases plasma dehydroepiandrosterone sulfate levels in adolescent male rats.	Dehydroepiandrosterone Sulfate	80-110	insulin	Homo sapiens	8-15
8307110-1	1993	The chronic effect of daily i. m. administration of ACTH (1 U/kg bodyweight (BW), group A) and of insulin (15/kg BW, group B) on circulating dehydroepiandrosterone sulfate (DHEA-S) and testosterone was investigated in postpubertal male Wistar rats.	Dehydroepiandrosterone Sulfate	141-171	insulin	Homo sapiens	98-105
1335208-7	1992	Angiotensin II stimulated the production of cortisol, dehydroepiandrosterone, and dehydroepiandrosterone sulfate production during treatment for 2 days.	Dehydroepiandrosterone Sulfate	82-112	angiotensinogen	Homo sapiens	0-14
8421087-0	1993	Effects of nitrendipine on glucose tolerance and serum insulin and dehydroepiandrosterone sulfate levels in insulin-resistant obese and hypertensive men.	Dehydroepiandrosterone Sulfate	67-97	insulin	Homo sapiens	108-115
8268149-4	1993	Free testosterone level was higher and estradiol level lower in hyperprolactinemic women than in control subjects (p &lt; 0.05), whereas dehydroepiandrosterone sulfate (DHEAS) and total testosterone levels were similar (p &gt; 0.05).	Dehydroepiandrosterone Sulfate	137-167	sulfotransferase family 2A member 1	Homo sapiens	169-174
1312904-4	1992	Prolactin (PRL) suppression in women with BBD receiving bromocriptine treatment was associated with a significant (p less than 0.02) decrease of baseline DHAS plasma levels and of stimulated ACTH response curve (p less than 0.02).	Dehydroepiandrosterone Sulfate	154-158	prolactin	Homo sapiens	0-9
1471703-6	1992	RESULTS: Dehydroepiandrosterone sulfate correlated negatively with fasting insulin (r = 0.4, p &lt; 0.05) and reached significance in those most obese.	Dehydroepiandrosterone Sulfate	9-39	insulin	Homo sapiens	75-82
1471703-9	1992	Although more atherogenic apolipoprotein profiles and higher fasting insulin concentrations were found with greater body weight, lipid-insulin interrelationships may reflect dehydroepiandrosterone sulfate interaction.	Dehydroepiandrosterone Sulfate	174-204	insulin	Homo sapiens	69-76
1471703-9	1992	Although more atherogenic apolipoprotein profiles and higher fasting insulin concentrations were found with greater body weight, lipid-insulin interrelationships may reflect dehydroepiandrosterone sulfate interaction.	Dehydroepiandrosterone Sulfate	174-204	insulin	Homo sapiens	135-142
1471703-10	1992	CONCLUSIONS: We hypothesize that dehydroepiandrosterone sulfate dampens the effect of insulin resistance, which in turn is reflected in apolipoprotein profiles in women with hirsutism/hyperandrogenism.	Dehydroepiandrosterone Sulfate	33-63	insulin	Homo sapiens	86-93
1459258-7	1992	All androgens decreased significantly over the 2-hour test in all groups except dehydroepiandrosterone sulfate (DHEAS) in the patients with both elevated PRL and abnormal glucose tolerance.	Dehydroepiandrosterone Sulfate	80-110	sulfotransferase family 2A member 1	Homo sapiens	112-117
1423966-1	1992	BACKGROUND: Antiatherogenic effects of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) have been suspected for more than 30 years, yet the available evidence to support or refute such effects in humans is inconclusive.	Dehydroepiandrosterone Sulfate	73-103	sulfotransferase family 2A member 1	Homo sapiens	105-110
1297319-1	1992	Treatment of cultured rat-hepatocytes with 50 microM dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) for up to 5 days resulted in a progressive increase in peroxisomal beta-oxidation and carnitine acetyltransferase activity.	Dehydroepiandrosterone Sulfate	100-105	carnitine O-acetyltransferase	Rattus norvegicus	193-220
1297319-2	1992	After 5 days, the increases in activity were 2.6- and 4.8-fold for peroxisomal beta-oxidation and 11.7- and 17.1-fold for carnitine acetyltransferase over the initial activity, in DHEA- and DHEAS-treated cells, respectively.	Dehydroepiandrosterone Sulfate	190-195	carnitine O-acetyltransferase	Rattus norvegicus	122-149
1445172-10	1992	Several studies in humans have demonstrated an acute decline in serum concentrations of the adrenal steroids DHEA and DHEA-sulfate in response to experimentally-induced hyperinsulinaemia, but the regulatory role of insulin on adrenal androgen metabolism in normal physiology or disease remains speculative.	Dehydroepiandrosterone Sulfate	118-130	insulin	Homo sapiens	174-181
1387652-4	1992	Since estrone sulfate (E1S) and its possible precursor, dehydroepiandrosterone sulfate (DHEAS) are elevated in BCF, E3S may originate via 16 alpha-hydroxylation of E1S.	Dehydroepiandrosterone Sulfate	56-86	sulfotransferase family 2A member 1	Homo sapiens	88-93
1321838-10	1992	Thus, activin selectively suppressed fetal zone proliferation and enhanced the ACTH-induced shift in the cortisol/dehydroepiandrosterone sulfate ratio of fetal zone steroid production.	Dehydroepiandrosterone Sulfate	114-144	inhibin subunit beta E	Homo sapiens	6-13
1321838-10	1992	Thus, activin selectively suppressed fetal zone proliferation and enhanced the ACTH-induced shift in the cortisol/dehydroepiandrosterone sulfate ratio of fetal zone steroid production.	Dehydroepiandrosterone Sulfate	114-144	proopiomelanocortin	Homo sapiens	79-83
1404349-1	1992	Serum dehydroepiandrosterone sulfate (DHEA-S) levels were measured in 270 men and 153 women who were experienced practitioners of the Transcendental Meditation (TM) and TM-Sidhi programs, mental techniques practiced twice daily, sitting quietly with the eyes closed.	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-44
1473220-4	1992	Even though DHA-S was found to increase uterine estrogen receptor concentration, this compound was shown to have no affinity for the estrogen receptor.	Dehydroepiandrosterone Sulfate	12-17	estrogen receptor 1	Rattus norvegicus	48-65
1386249-0	1992	Dehydroepiandrosterone sulfate and other possible influencing factors that modulate sex hormone-binding globulin levels in the hirsute patient.	Dehydroepiandrosterone Sulfate	0-30	sex hormone binding globulin	Homo sapiens	84-112
1314844-11	1992	DHEA sulfate (DHEAS) was significantly lower than control at both 24 and 72 h post prednisolone (1.8 +/- 0.3 and 3.3 +/- 0.4 mumol/L respectively; control 7.2 +/- 0.7 mumol/L; P less than 0.001).	Dehydroepiandrosterone Sulfate	0-12	sulfotransferase family 2A member 1	Homo sapiens	14-19
1535720-1	1992	To establish the possible relationship between acute myocardial infarction (AMI) and dehydroepiandrosterone-sulfate (DHEA-S) in a group of 15 patients with AMI, blood levels of DHEA-S and certain lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) were determined at admission in the hospital and after 10 days.	Dehydroepiandrosterone Sulfate	85-115	sulfotransferase family 2A member 1	Homo sapiens	117-123
1532567-4	1992	A direct link between nutritional factors and secretion of the hormones prolactin and dehydroepiandrosterone sulfate is proposed.	Dehydroepiandrosterone Sulfate	86-116	prolactin	Homo sapiens	72-81
1606923-8	1992	The Km and Vmax values of the steroid sulfatase for dehydroepiandrosterone sulfate (DHA-S) were 7.8 microM and 0.56 nmol/min, while those for estrone sulfate (E1-S) were 50.6 microM and 0.33 nmol/min, respectively.	Dehydroepiandrosterone Sulfate	52-82	arylsulfatase family member H	Homo sapiens	38-47
1606923-8	1992	The Km and Vmax values of the steroid sulfatase for dehydroepiandrosterone sulfate (DHA-S) were 7.8 microM and 0.56 nmol/min, while those for estrone sulfate (E1-S) were 50.6 microM and 0.33 nmol/min, respectively.	Dehydroepiandrosterone Sulfate	84-89	arylsulfatase family member H	Homo sapiens	38-47
1312904-4	1992	Prolactin (PRL) suppression in women with BBD receiving bromocriptine treatment was associated with a significant (p less than 0.02) decrease of baseline DHAS plasma levels and of stimulated ACTH response curve (p less than 0.02).	Dehydroepiandrosterone Sulfate	154-158	prolactin	Homo sapiens	11-14
1312904-5	1992	These data suggest a possible relationship between PRL and DHAS secretion in women with BBD.	Dehydroepiandrosterone Sulfate	59-63	prolactin	Homo sapiens	51-54
1329402-3	1992	The mean values of all but one (PRL) of the hormone and protein levels varied significantly from the controls, T, DHEAS, FAI and ALG showing the greatest differences.	Dehydroepiandrosterone Sulfate	114-119	prolactin	Homo sapiens	32-35
1530789-1	1992	In recent years, relationships of dehydroepiandrosterone and its sulfate ester dehydroepiandrosterone sulfate (DHEAS) with decreased risks of cardiovascular disease as well as a possible role in the aging process have been postulated.	Dehydroepiandrosterone Sulfate	79-109	sulfotransferase family 2A member 1	Homo sapiens	111-116
1840419-5	1991	It is demonstrated that human leukocytes contain a sulfatase activity for pregnenolone sulfate (P5-S), dehydroepiandrosterone sulfate (DHA-S) and estrone sulfate (E1-S) respectively.	Dehydroepiandrosterone Sulfate	103-133	arylsulfatase family member H	Homo sapiens	51-60
1840419-5	1991	It is demonstrated that human leukocytes contain a sulfatase activity for pregnenolone sulfate (P5-S), dehydroepiandrosterone sulfate (DHA-S) and estrone sulfate (E1-S) respectively.	Dehydroepiandrosterone Sulfate	135-140	arylsulfatase family member H	Homo sapiens	51-60
1827032-6	1991	Compared with the non-PCO group, the PCO subgroup without hirsutism (n = 31) had statistically significantly higher median values of LH, testosterone, androstenedione, and dehydroepiandrosterone sulphate concentrations, and free androgen index.	Dehydroepiandrosterone Sulfate	172-203	PCOS1	Homo sapiens	37-40
1839975-3	1991	This study sought to examine the changes in peripheral cortisol, progesterone and dehydroepiandrosterone sulphate (DHEAS) in unstressed fetuses during pregnancy.	Dehydroepiandrosterone Sulfate	82-113	sulfotransferase family 2A member 1	Homo sapiens	115-120
1835444-0	1991	Serum dehydroepiandrosterone sulphate (DHEAS) and dehydroepiandrosterone (DHEA) levels in hairy-cell leukaemia.	Dehydroepiandrosterone Sulfate	6-37	sulfotransferase family 2A member 1	Homo sapiens	39-44
1832424-1	1991	Extending a series of previous investigations on the regulatory interaction of insulin and androgens, this study tests the hypothesis that the physiological insulinemia after oral glucose suppresses circulating dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S), and androstenedione (delta 4A) delta 4 in normal women.	Dehydroepiandrosterone Sulfate	242-272	sulfotransferase family 2A member 1	Homo sapiens	274-280
1831739-2	1991	Comparison with normal subjects revealed the following changes: (1) Basal dehydroepiandrosterone sulphate (DHEAS) values were decreased in the ill female patients (P less than 0.001) as well as in the ill males (two groups, P less than 0.01; P less than 0.05).	Dehydroepiandrosterone Sulfate	74-105	sulfotransferase family 2A member 1	Homo sapiens	107-112
1826009-1	1991	Extreme pharmacological elevation of the circulating insulin level acutely lowers dehydroepiandrosterone sulfate (DHEAS) levels.	Dehydroepiandrosterone Sulfate	82-112	insulin	Homo sapiens	53-60
1826009-1	1991	Extreme pharmacological elevation of the circulating insulin level acutely lowers dehydroepiandrosterone sulfate (DHEAS) levels.	Dehydroepiandrosterone Sulfate	82-112	sulfotransferase family 2A member 1	Homo sapiens	114-119
1314859-2	1992	In addition the adrenal secretion of dehydroepiandrosterone sulphate was assessed by means of an ACTH stimulation test in some patients and control subjects.	Dehydroepiandrosterone Sulfate	37-68	proopiomelanocortin	Homo sapiens	97-101
1666369-3	1991	We show here that the steroids (0.1-100 microM) allotetrahydrocorticosterone (THCC), dehydroepiandrosterone sulfate (DHEAS) and pregnanolone can rapidly and reversibly depress voltage-gated calcium currents in freshly isolated adult hippocampal CA1 pyramidal neurons.	Dehydroepiandrosterone Sulfate	85-115	carbonic anhydrase 1	Homo sapiens	245-248
1666369-3	1991	We show here that the steroids (0.1-100 microM) allotetrahydrocorticosterone (THCC), dehydroepiandrosterone sulfate (DHEAS) and pregnanolone can rapidly and reversibly depress voltage-gated calcium currents in freshly isolated adult hippocampal CA1 pyramidal neurons.	Dehydroepiandrosterone Sulfate	117-122	carbonic anhydrase 1	Homo sapiens	245-248
1832389-15	1991	There was a close relation between prolactin and DHA-S levels (p less than 0.05).	Dehydroepiandrosterone Sulfate	49-54	prolactin	Rattus norvegicus	35-44
1832389-18	1991	To our knowledge, this is the first demonstration of a significant relation between prolactin and DHA-S in immature female rats.	Dehydroepiandrosterone Sulfate	98-103	prolactin	Rattus norvegicus	84-93
1847859-10	1991	The secretion of ACTH-stimulated cortisol, dehydroepiandrosterone sulfate, and aldosterone was decreased by TPA in both fetal and adult cultures.	Dehydroepiandrosterone Sulfate	43-73	proopiomelanocortin	Homo sapiens	17-21
2066864-5	1991	P-450 HFLa catalyzed 16 alpha-hydroxylation of dehydroepiandrosterone 3-sulfate (DHEA-sulfate) in a reconstituted system.	Dehydroepiandrosterone Sulfate	47-79	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	0-10
2066864-5	1991	P-450 HFLa catalyzed 16 alpha-hydroxylation of dehydroepiandrosterone 3-sulfate (DHEA-sulfate) in a reconstituted system.	Dehydroepiandrosterone Sulfate	81-93	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	0-10
1825938-5	1991	Of the sex hormones, the adrenal androgen dehydroepiandrosterone sulphate (DHEAS) correlated best with spinal BMC, a relationship which was significant using multiple regression (P = 0.02), although the correlation was weak (r = +0.19).	Dehydroepiandrosterone Sulfate	42-73	sulfotransferase family 2A member 1	Homo sapiens	75-80
1929551-3	1991	Urinary excretion of hydroxyproline in patients was found to correlate significantly with total testosterone (P = 0.035), with DHT (P = 0.005) and dehydroepiandrosterone-sulphate (DHEAS) (P = 0.034).	Dehydroepiandrosterone Sulfate	147-178	sulfotransferase family 2A member 1	Homo sapiens	180-185
1838953-4	1991	IGF-I concentration was higher in cysts with a Na+/K+ ratio greater than 3 (greater than 3) and was inversely related to both dehydroepiandrosterone sulfate (DHEA-S) and epidermal growth factor (EGF) concentration (p less than 0.001).	Dehydroepiandrosterone Sulfate	126-156	insulin like growth factor 1	Homo sapiens	0-5
1838953-4	1991	IGF-I concentration was higher in cysts with a Na+/K+ ratio greater than 3 (greater than 3) and was inversely related to both dehydroepiandrosterone sulfate (DHEA-S) and epidermal growth factor (EGF) concentration (p less than 0.001).	Dehydroepiandrosterone Sulfate	158-164	insulin like growth factor 1	Homo sapiens	0-5
2146126-1	1990	The case of a 17-year-old male with isolated hypersecretion of dehydroepiandrosterone sulphate (DHEAS) is described.	Dehydroepiandrosterone Sulfate	63-94	sulfotransferase family 2A member 1	Homo sapiens	96-101
1828959-4	1991	In both cysts and secretions levels of ZnGP correlated with those of dehydroepiandrosterone sulphate.	Dehydroepiandrosterone Sulfate	69-100	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	39-43
1835649-5	1991	These studies show that experimentally-induced hyperinsulinemia lowers serum DHA and DHA-sulfate levels, and suggest that insulin reduces serum concentrations of these steroids by inhibiting production rather than by increasing clearance.	Dehydroepiandrosterone Sulfate	85-96	insulin	Homo sapiens	52-59
2150469-1	1990	The concentration of dehydroepiandrosterone sulphate (DHEAS) was measured in the plasma of 104 patients aged 16-78 years (48 men) undergoing routine assessment of anterior pituitary reserve.	Dehydroepiandrosterone Sulfate	21-52	sulfotransferase family 2A member 1	Homo sapiens	54-59
2145063-1	1990	It has been suggested that dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS), have a protective effect against breast cancer.	Dehydroepiandrosterone Sulfate	80-110	sulfotransferase family 2A member 1	Homo sapiens	112-117
2145221-4	1990	Adrenal androgen production was estimated from urinary excretion of adrenal androgen metabolites that showed cross-reactivity with antisera to dehydroepiandrosterone sulfate (DHEA-S).	Dehydroepiandrosterone Sulfate	143-173	sulfotransferase family 2A member 1	Homo sapiens	175-181
2147671-1	1990	Prior studies have reported men with coronary artery disease (CAD) to have elevated plasma levels of estrogens and reduced concentrations of dehydroepiandrosterone (DHEA) or DHEA-sulfate (DHEAS).	Dehydroepiandrosterone Sulfate	174-186	sulfotransferase family 2A member 1	Homo sapiens	188-193
2140921-9	1990	Our data contradict the hypothesis that the low insulin sensitivity of puberty is due to the increased levels of DHEA-S.	Dehydroepiandrosterone Sulfate	113-119	insulin	Homo sapiens	48-55
2146099-2	1990	The circadian profiles of cortisol and dehydroepiandrosterone sulphate (DHEA-S) were analyzed in a homogeneous group of 15 young normally cycling women, at 4 times of the menstrual cycle: early follicular (EF), late follicular (LF), early luteal (EL) and late luteal (LL) stages.	Dehydroepiandrosterone Sulfate	39-70	sulfotransferase family 2A member 1	Homo sapiens	72-78
2147737-2	1990	It was found that dehydroepiandrosterone sulphate (DHEA-S), oestradiol (E2) and delta-4-androstenedione (A) were correlated with BMC, whereas oestrone (E1) and testosterone (T) were not.	Dehydroepiandrosterone Sulfate	18-49	sulfotransferase family 2A member 1	Homo sapiens	51-57
2142388-9	1990	In prepubertal patients, somatomedin C/IGF I was slightly but highly significantly correlated to growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated with each other.	Dehydroepiandrosterone Sulfate	165-195	insulin like growth factor 1	Homo sapiens	25-38
2142388-9	1990	In prepubertal patients, somatomedin C/IGF I was slightly but highly significantly correlated to growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated with each other.	Dehydroepiandrosterone Sulfate	165-195	insulin like growth factor 1	Homo sapiens	39-44
2142388-9	1990	In prepubertal patients, somatomedin C/IGF I was slightly but highly significantly correlated to growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated with each other.	Dehydroepiandrosterone Sulfate	250-280	insulin like growth factor 1	Homo sapiens	25-38
2142388-9	1990	In prepubertal patients, somatomedin C/IGF I was slightly but highly significantly correlated to growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated with each other.	Dehydroepiandrosterone Sulfate	250-280	insulin like growth factor 1	Homo sapiens	39-44
2140335-0	1990	[Dehydroepiandrosterone sulfate (DHEAS) concentration changes in clomiphene therapy?].	Dehydroepiandrosterone Sulfate	1-31	sulfotransferase family 2A member 1	Homo sapiens	33-38
2139448-1	1990	Previous studies have shown the normal range of plasma dehydroepiandrosterone sulfate (DHEAS) for independent community men over 60 years old to be 30-200 micrograms/dL.	Dehydroepiandrosterone Sulfate	55-85	sulfotransferase family 2A member 1	Homo sapiens	87-92
2138277-9	1990	In prepubertal patients, somatomedin C/IGFI was slightly but highly significantly correlated to the growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated together.	Dehydroepiandrosterone Sulfate	168-198	insulin like growth factor 1	Homo sapiens	25-38
2149058-3	1990	Moreover, dehydroepiandrosterone sulfate (DHEA-S) levels and cell cycle kinetics obtained from the hirsute females yielded a strong correlation between the height of S-phase percentages and DHEA-S values, whereas no correlation could be proved between testosterone levels and DNA-FCM data.	Dehydroepiandrosterone Sulfate	10-40	sulfotransferase family 2A member 1	Homo sapiens	42-48
2149058-3	1990	Moreover, dehydroepiandrosterone sulfate (DHEA-S) levels and cell cycle kinetics obtained from the hirsute females yielded a strong correlation between the height of S-phase percentages and DHEA-S values, whereas no correlation could be proved between testosterone levels and DNA-FCM data.	Dehydroepiandrosterone Sulfate	10-40	sulfotransferase family 2A member 1	Homo sapiens	190-196
2137387-0	1990	Serum lipoprotein profile and concentration of dehydroepiandrosterone sulfate (DHEAS) in glucose-6-phosphate dehydrogenase-deficient subjects.	Dehydroepiandrosterone Sulfate	47-77	sulfotransferase family 2A member 1	Homo sapiens	79-84
2143469-6	1990	3 beta-HSD activity in the placentae from the mothers who received DHA-S before delivery was significantly lower than in the controls.	Dehydroepiandrosterone Sulfate	67-72	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	0-10
2143469-9	1990	To study the direct effect of DHA-S and its related steroids on placental 3 beta-HSD activity, placental tissue samples were incubated with pregnenolone in vitro.	Dehydroepiandrosterone Sulfate	30-35	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	74-84
2143469-11	1990	It was observed that placental 3 beta-HSD activity was directly inhibited by DHA-S.	Dehydroepiandrosterone Sulfate	77-82	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	31-41
2143469-12	1990	These results indicate that DHA-S inhibits 3 beta-HSD activity in the placenta and subsequently causes a reduction in P and 20-P.	Dehydroepiandrosterone Sulfate	28-33	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	43-53
2138277-9	1990	In prepubertal patients, somatomedin C/IGFI was slightly but highly significantly correlated to the growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated together.	Dehydroepiandrosterone Sulfate	168-198	insulin like growth factor 1	Homo sapiens	39-43
2138277-9	1990	In prepubertal patients, somatomedin C/IGFI was slightly but highly significantly correlated to the growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated together.	Dehydroepiandrosterone Sulfate	253-283	insulin like growth factor 1	Homo sapiens	25-38
2138277-9	1990	In prepubertal patients, somatomedin C/IGFI was slightly but highly significantly correlated to the growth hormone sleep secretion (r = 0.27, p less than 0.001) and to dehydroepiandrosterone sulfate (r = 0.36, p less than 0.001), but growth hormone and dehydroepiandrosterone sulfate were not correlated together.	Dehydroepiandrosterone Sulfate	253-283	insulin like growth factor 1	Homo sapiens	39-43
34838827-1	2022	OBJECTIVE: To analyze the association of circulating dehydroepiandrosterone sulfate (DHEA-S) levels with cardiovascular outcomes in patients with chronic Chagas cardiomyopathy (CCM) diagnosis.	Dehydroepiandrosterone Sulfate	53-83	sulfotransferase family 2A member 1	Homo sapiens	85-91
2137141-3	1990	We investigated the dose-response relationship for suppression of dehydroepiandrosterone sulfate (DHEAS) with the use of dexamethasone.	Dehydroepiandrosterone Sulfate	66-96	sulfotransferase family 2A member 1	Homo sapiens	98-103
33821626-3	2021	In the fetus and neonates, cytochrome P450 CYP3A7 is responsible for the metabolism of DHEA-S into 16alpha-hydroxy DHEA-S, which plays a critical role in growth and development.	Dehydroepiandrosterone Sulfate	87-93	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	43-49
33821626-3	2021	In the fetus and neonates, cytochrome P450 CYP3A7 is responsible for the metabolism of DHEA-S into 16alpha-hydroxy DHEA-S, which plays a critical role in growth and development.	Dehydroepiandrosterone Sulfate	115-121	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	43-49
33821626-5	2021	We identified ritonavir as a potent inhibitor of CYP3A7 oxidation of DHEA-S (IC50 = 0.0514 muM), while lopinavir is a much weaker inhibitor (IC50 = 5.88 muM).	Dehydroepiandrosterone Sulfate	69-75	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	49-55
33803980-1	2021	The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established.	Dehydroepiandrosterone Sulfate	31-62	sulfotransferase family 2A member 1	Homo sapiens	64-70
33803980-1	2021	The relationship between serum dehydroepiandrosterone sulphate (DHEA-S) and anti-Mullerian hormone (AMH) levels has not been fully established.	Dehydroepiandrosterone Sulfate	31-62	anti-Mullerian hormone	Homo sapiens	100-103
2161262-11	1990	Continuous treatment with 1 nM ACTH increased dehydroepiandrosterone sulfate (DHAS) production 5- to 10-fold during the first 5 days in culture.	Dehydroepiandrosterone Sulfate	46-76	proopiomelanocortin	Homo sapiens	31-35
2161262-11	1990	Continuous treatment with 1 nM ACTH increased dehydroepiandrosterone sulfate (DHAS) production 5- to 10-fold during the first 5 days in culture.	Dehydroepiandrosterone Sulfate	78-82	proopiomelanocortin	Homo sapiens	31-35
33779531-7	2021	Levels of the AR ligand precursor dehydroepiandrosterone sulfate (DHEA-S) correlated positively with FEV1 in both women and men.	Dehydroepiandrosterone Sulfate	34-64	androgen receptor	Homo sapiens	14-16
33779531-7	2021	Levels of the AR ligand precursor dehydroepiandrosterone sulfate (DHEA-S) correlated positively with FEV1 in both women and men.	Dehydroepiandrosterone Sulfate	66-72	androgen receptor	Homo sapiens	14-16
33771511-10	2021	Poor CYP2C19 and CYP2D6 metabolizers (GA and AA genotype carriers) showed a greater increase in DHEAS for detected versus undetected 1N compared with GG genotype carriers.	Dehydroepiandrosterone Sulfate	96-101	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	5-12
33771511-10	2021	Poor CYP2C19 and CYP2D6 metabolizers (GA and AA genotype carriers) showed a greater increase in DHEAS for detected versus undetected 1N compared with GG genotype carriers.	Dehydroepiandrosterone Sulfate	96-101	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	17-23
34370329-8	2021	RESULTS: Circulatory-DHEA-S levels in pregnant women with ABO were higher than women with NBO (p=0.043).	Dehydroepiandrosterone Sulfate	21-27	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	58-61
34904249-2	2022	Our aim was to assess whether the presence of high dehydroepiandrosterone sulphate (DHEAS (HD)) at the adrenarche determines the risk of metabolic syndrome during puberty, taking into account body mass index (BMI) and birth weight.	Dehydroepiandrosterone Sulfate	51-82	sulfotransferase family 2A member 1	Homo sapiens	84-89
34935937-2	2022	The causal effect of endogenous adrenal-derived DHEA-sulphate (DHEAS) on LS-BMD and fracture risk in women is unknown.	Dehydroepiandrosterone Sulfate	48-61	sulfotransferase family 2A member 1	Homo sapiens	63-68
34370329-9	2021	Among ABO, only stillbirth cases demonstrated significant increase in circulatory-DHEA-S levels (p=0.006).	Dehydroepiandrosterone Sulfate	82-88	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	6-9
34370329-11	2021	Consistently, increased odds of ABO were observed in pregnant women with highest circulatory-DHEA-S levels (odds ratio quartile score 1 vs 4, 2.79, p=0.027) and lowest salivary cortisol/DHEA-S ratio (score 4 vs 2, 2.83, p=0.025).	Dehydroepiandrosterone Sulfate	93-99	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	32-35
34628357-5	2021	While bromosulfophthalein and atorvastatin were substrates of both transporters, the steroid sulfate conjugates estrone 3-sulfate (E1S), progesterone sulfate and dehydroepiandrosterone sulfate were only transported by hOATP2B1.	Dehydroepiandrosterone Sulfate	162-192	solute carrier organic anion transporter family member 2B1	Homo sapiens	218-226
34852451-8	2021	Subjects with PRKACA L206R mutant CPAs showed smaller adenoma size (3.3+-0.7 cm vs. 3.8+-1.2 cm, P=0.059) and lower dehydroepiandrosterone sulfate levels (218+-180 ng/mL vs. 1,511+-3,307 ng/mL, P=0.001) than those with PRKACA wild-type CPAs.	Dehydroepiandrosterone Sulfate	116-146	protein kinase cAMP-activated catalytic subunit alpha	Homo sapiens	14-20
34162776-1	2021	Serum dehydroepiandrosterone sulfate (DHEA-S) levels reflect the state of adrenocorticotropic hormone (ACTH) secretion.	Dehydroepiandrosterone Sulfate	6-36	proopiomelanocortin	Homo sapiens	74-101
34929017-0	2021	Inter-individual differences in pain anticipation and pain perception in migraine: Neural correlates of migraine frequency and cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio.	Dehydroepiandrosterone Sulfate	139-169	sulfotransferase family 2A member 1	Homo sapiens	171-177
34929017-2	2021	Our main aim was to disentangle pain anticipation and perception using a classical fear conditioning task, and investigate how migraine frequency and pre-scan cortisol-to-dehydroepiandrosterone sulfate (DHEA-S) ratio as an index of neurobiological stress response would relate to neural activation in these two phases.	Dehydroepiandrosterone Sulfate	171-201	sulfotransferase family 2A member 1	Homo sapiens	203-209
34162776-1	2021	Serum dehydroepiandrosterone sulfate (DHEA-S) levels reflect the state of adrenocorticotropic hormone (ACTH) secretion.	Dehydroepiandrosterone Sulfate	6-36	proopiomelanocortin	Homo sapiens	103-107
34162776-1	2021	Serum dehydroepiandrosterone sulfate (DHEA-S) levels reflect the state of adrenocorticotropic hormone (ACTH) secretion.	Dehydroepiandrosterone Sulfate	38-44	proopiomelanocortin	Homo sapiens	74-101
34162776-1	2021	Serum dehydroepiandrosterone sulfate (DHEA-S) levels reflect the state of adrenocorticotropic hormone (ACTH) secretion.	Dehydroepiandrosterone Sulfate	38-44	proopiomelanocortin	Homo sapiens	103-107
34674406-8	2022	Serum dehydroepiandrosterone sulfate (DHEAS) levels were significantly higher in stage IV than in stage I (p=0.03).	Dehydroepiandrosterone Sulfate	6-36	sulfotransferase family 2A member 1	Homo sapiens	38-43
34289182-4	2021	RESULTS: Dehydroepiandrosterone sulphate concentrations correlated with weight standard deviations scores (SDS) from 7-10 years of age and waist-to-height ratios at seven and 10 years of age.	Dehydroepiandrosterone Sulfate	9-40	renin binding protein	Homo sapiens	131-134
34289182-4	2021	RESULTS: Dehydroepiandrosterone sulphate concentrations correlated with weight standard deviations scores (SDS) from 7-10 years of age and waist-to-height ratios at seven and 10 years of age.	Dehydroepiandrosterone Sulfate	9-40	renin binding protein	Homo sapiens	187-190
34688910-5	2021	Twelve congeners of PCB sulfates were substrates for the microsomal sulfatase with catalytic rates exceeding that of dehydroepiandrosterone sulfate as a comparison substrate for steroid sulfatase (STS).	Dehydroepiandrosterone Sulfate	117-147	arylsulfatase family member H	Homo sapiens	68-77
34688910-5	2021	Twelve congeners of PCB sulfates were substrates for the microsomal sulfatase with catalytic rates exceeding that of dehydroepiandrosterone sulfate as a comparison substrate for steroid sulfatase (STS).	Dehydroepiandrosterone Sulfate	117-147	steroid sulfatase	Homo sapiens	178-195
34417562-1	2021	BACKGROUND: Low birth size (BS) and obesity have been associated with higher dehydroepiandrosterone sulfate (DHEAS) levels in childhood, insulin acting as a mediator, despite contradictory findings.	Dehydroepiandrosterone Sulfate	77-107	insulin	Homo sapiens	137-144
34594217-5	2021	Compared to reference OATP2B1, the transport activities of the c.332G>A, c.601G>A and c.1457C>T variants were reduced among the substrates examined (estrone sulfate, DHEAS, CPI, CPIII and rosuvastatin), although there were substrate-dependent effects.	Dehydroepiandrosterone Sulfate	166-171	solute carrier organic anion transporter family member 2B1	Homo sapiens	22-29
34675221-1	2021	Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.	Dehydroepiandrosterone Sulfate	76-106	steroid sulfatase	Homo sapiens	6-23
34675221-1	2021	Human steroid sulfatase (STS) is an enzyme that catalyzes the hydrolysis of dehydroepiandrosterone sulfate (DHEAS), estrone sulfate (E1S), and cholesterol sulfate.	Dehydroepiandrosterone Sulfate	108-113	steroid sulfatase	Homo sapiens	6-23
34417562-1	2021	BACKGROUND: Low birth size (BS) and obesity have been associated with higher dehydroepiandrosterone sulfate (DHEAS) levels in childhood, insulin acting as a mediator, despite contradictory findings.	Dehydroepiandrosterone Sulfate	109-114	insulin	Homo sapiens	137-144
34157116-1	2021	PURPOSE: Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially decreases with age, which may accelerate osteoporosis.	Dehydroepiandrosterone Sulfate	9-39	sulfotransferase family 2A member 1	Homo sapiens	41-46
34273785-1	2021	INTRODUCTION: Dehydroepiandrosterone sulfate (DHEAS) has been reported to be associated with sexual function and general psychological health respectively, however, no one has ever examined their mutual relationships in a single study.	Dehydroepiandrosterone Sulfate	14-44	sulfotransferase family 2A member 1	Homo sapiens	46-51
35294643-1	2022	We aimed to explore the effect of dehydroepiandrosterone sulphate (DHEAS) at age 7 on areal bone mineral density (aBMD) at age 10 and to distinguish the direct and indirect effects (explained by sexual maturity and by aBMD at age 7), for each sex, after adjustment for body mass index (BMI) z-score.	Dehydroepiandrosterone Sulfate	34-65	sulfotransferase family 2A member 1	Homo sapiens	67-72
34415029-1	2021	PURPOSE: Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially decreases with age, which may accelerate osteoporosis.	Dehydroepiandrosterone Sulfate	9-39	sulfotransferase family 2A member 1	Homo sapiens	41-46
34079822-10	2021	The HBV/HDV-derived myr-preS1 peptide showed equipotent inhibition of the NTCP-mediated substrate transport of taurocholic acid (TC), dehydroepiandrosterone sulfate (DHEAS), and TLC with IC50 values of 182 nM, 167 nM, and 316 nM, respectively.	Dehydroepiandrosterone Sulfate	134-164	solute carrier family 10 member 1	Homo sapiens	74-78
34079822-10	2021	The HBV/HDV-derived myr-preS1 peptide showed equipotent inhibition of the NTCP-mediated substrate transport of taurocholic acid (TC), dehydroepiandrosterone sulfate (DHEAS), and TLC with IC50 values of 182 nM, 167 nM, and 316 nM, respectively.	Dehydroepiandrosterone Sulfate	166-171	solute carrier family 10 member 1	Homo sapiens	74-78
35074787-1	2022	Estrogen biosynthesis in human placental trophoblasts requires the hOAT4-mediated uptake of fetal derived precursors such as dehydroepiandrosterone-3-sulfate (DHEAS) and 16alpha-hydroxy-DHEA-S (16alpha-OH-DHEAS).	Dehydroepiandrosterone Sulfate	125-157	solute carrier family 22 member 9	Homo sapiens	67-72
35630701-6	2022	The limits of detection (S/N = 3) of PREGS, DHEAS, CRTS, and E2S were 0.59, 0.30, 0.80, and 3.20 pg mL-1, respectively.	Dehydroepiandrosterone Sulfate	44-49	L1 cell adhesion molecule	Mus musculus	100-104
35074787-1	2022	Estrogen biosynthesis in human placental trophoblasts requires the hOAT4-mediated uptake of fetal derived precursors such as dehydroepiandrosterone-3-sulfate (DHEAS) and 16alpha-hydroxy-DHEA-S (16alpha-OH-DHEAS).	Dehydroepiandrosterone Sulfate	159-164	solute carrier family 22 member 9	Homo sapiens	67-72
35074787-8	2022	Significance Statement Fetal metabolites, especially bilirubin, was first identified with significant inhibitory effects on the hOAT4-mediated uptake of estrogen precursor DHEAS in hOAT4-CHO, JEG-3 and PHTCs.	Dehydroepiandrosterone Sulfate	172-177	solute carrier family 22 member 9	Homo sapiens	128-133
35074787-8	2022	Significance Statement Fetal metabolites, especially bilirubin, was first identified with significant inhibitory effects on the hOAT4-mediated uptake of estrogen precursor DHEAS in hOAT4-CHO, JEG-3 and PHTCs.	Dehydroepiandrosterone Sulfate	172-177	solute carrier family 22 member 9	Homo sapiens	181-186
35074787-9	2022	Bilirubin concentration-dependently suppressed the estradiol synthesis and secretion in PHTCs treated with DHEAS, which was synchronized with the decline of hOAT4 protein expression.	Dehydroepiandrosterone Sulfate	107-112	solute carrier family 22 member 9	Homo sapiens	157-162
35227621-5	2022	Four separate meta-analyses were conducted for total T, free T, Free Androgen Index (FAI), and Dehydroepiandrosterone sulphate (DHEAS).	Dehydroepiandrosterone Sulfate	95-126	sulfotransferase family 2A member 1	Homo sapiens	128-133
35355907-9	2021	Significant results were observed in rs1799817 single nucleotide polymorphisms (SNP) of INSR with elevated levels of triglycerides and rs10818854 of DENND1A, rs13429458 of THADA, rs2349415 of FSHR with the high levels of DHEAS.	Dehydroepiandrosterone Sulfate	221-226	insulin receptor	Homo sapiens	88-92
35355907-9	2021	Significant results were observed in rs1799817 single nucleotide polymorphisms (SNP) of INSR with elevated levels of triglycerides and rs10818854 of DENND1A, rs13429458 of THADA, rs2349415 of FSHR with the high levels of DHEAS.	Dehydroepiandrosterone Sulfate	221-226	DENN domain containing 1A	Homo sapiens	149-156
35355907-10	2021	Conclusion: In the study population, the presence of rs10818854 of DENND1A polymorphism may be associated with the risk of PCOS and high levels of DHEAS.	Dehydroepiandrosterone Sulfate	147-152	DENN domain containing 1A	Homo sapiens	67-74
35150162-1	2022	OBJECTIVE: To assess the influence of longitudinal weight gain from 0 to 4 years old on dehydroepiandrosterone sulphate (DHEAS) levels at 7 years old.	Dehydroepiandrosterone Sulfate	88-119	sulfotransferase family 2A member 1	Homo sapiens	121-126
35415222-14	2022	Discussion: PAPSS2 assists with the sulfonation of dehydroepiandrosterone (DHEA) to DHEA sulfate and the sulfonation of proteoglycans in the cartilage, necessary for endochondral bone formation.	Dehydroepiandrosterone Sulfate	84-96	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	12-18