PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11121402-5	2001	Expression of constitutively active Rac1(Val-12) augmented p38 MAP kinase activation and alpha(2)-cytoplasmic domain-dependent migration.	val-12	41-47	Rac family small GTPase 1	Homo sapiens	36-40
11371552-5	2001	Induction of Ha-Ras(Val-12) caused a decrease in the level of Smad4 expression, inhibited TGF-beta-induced complex formation between Smad2/Smad3 and Smad4, blocked Smad4 nuclear translocation, inhibited the TGF-beta-mediated decrease in [(3)H]thymidine incorporation, and repressed TGF-beta-activated transcriptional responses.	val-12	20-26	SMAD family member 4	Homo sapiens	62-67
11371552-5	2001	Induction of Ha-Ras(Val-12) caused a decrease in the level of Smad4 expression, inhibited TGF-beta-induced complex formation between Smad2/Smad3 and Smad4, blocked Smad4 nuclear translocation, inhibited the TGF-beta-mediated decrease in [(3)H]thymidine incorporation, and repressed TGF-beta-activated transcriptional responses.	val-12	20-26	transforming growth factor beta 1	Homo sapiens	90-98
11371552-5	2001	Induction of Ha-Ras(Val-12) caused a decrease in the level of Smad4 expression, inhibited TGF-beta-induced complex formation between Smad2/Smad3 and Smad4, blocked Smad4 nuclear translocation, inhibited the TGF-beta-mediated decrease in [(3)H]thymidine incorporation, and repressed TGF-beta-activated transcriptional responses.	val-12	20-26	SMAD family member 2	Homo sapiens	133-138
11371552-5	2001	Induction of Ha-Ras(Val-12) caused a decrease in the level of Smad4 expression, inhibited TGF-beta-induced complex formation between Smad2/Smad3 and Smad4, blocked Smad4 nuclear translocation, inhibited the TGF-beta-mediated decrease in [(3)H]thymidine incorporation, and repressed TGF-beta-activated transcriptional responses.	val-12	20-26	SMAD family member 3	Homo sapiens	139-144
11371552-5	2001	Induction of Ha-Ras(Val-12) caused a decrease in the level of Smad4 expression, inhibited TGF-beta-induced complex formation between Smad2/Smad3 and Smad4, blocked Smad4 nuclear translocation, inhibited the TGF-beta-mediated decrease in [(3)H]thymidine incorporation, and repressed TGF-beta-activated transcriptional responses.	val-12	20-26	SMAD family member 4	Homo sapiens	149-154
11371552-5	2001	Induction of Ha-Ras(Val-12) caused a decrease in the level of Smad4 expression, inhibited TGF-beta-induced complex formation between Smad2/Smad3 and Smad4, blocked Smad4 nuclear translocation, inhibited the TGF-beta-mediated decrease in [(3)H]thymidine incorporation, and repressed TGF-beta-activated transcriptional responses.	val-12	20-26	SMAD family member 4	Homo sapiens	149-154
11371552-5	2001	Induction of Ha-Ras(Val-12) caused a decrease in the level of Smad4 expression, inhibited TGF-beta-induced complex formation between Smad2/Smad3 and Smad4, blocked Smad4 nuclear translocation, inhibited the TGF-beta-mediated decrease in [(3)H]thymidine incorporation, and repressed TGF-beta-activated transcriptional responses.	val-12	20-26	transforming growth factor beta 1	Homo sapiens	207-215
11371552-5	2001	Induction of Ha-Ras(Val-12) caused a decrease in the level of Smad4 expression, inhibited TGF-beta-induced complex formation between Smad2/Smad3 and Smad4, blocked Smad4 nuclear translocation, inhibited the TGF-beta-mediated decrease in [(3)H]thymidine incorporation, and repressed TGF-beta-activated transcriptional responses.	val-12	20-26	transforming growth factor beta 1	Homo sapiens	207-215
11121402-5	2001	Expression of constitutively active Rac1(Val-12) augmented p38 MAP kinase activation and alpha(2)-cytoplasmic domain-dependent migration.	val-12	41-47	mitogen-activated protein kinase 14	Homo sapiens	59-62
11080497-11	2001	Constitutively active Ras(Val-12) increased the TRAF6 induced activity of the NF-kappa B pathway similar to the effect induced by IL-1, while the Ras(Val-12) induced activity was not inhibited by co-transfection with a dominant negative TRAF6.	val-12	26-32	TNF receptor associated factor 6	Homo sapiens	48-53
11080497-11	2001	Constitutively active Ras(Val-12) increased the TRAF6 induced activity of the NF-kappa B pathway similar to the effect induced by IL-1, while the Ras(Val-12) induced activity was not inhibited by co-transfection with a dominant negative TRAF6.	val-12	26-32	nuclear factor kappa B subunit 1	Homo sapiens	78-88
11080497-11	2001	Constitutively active Ras(Val-12) increased the TRAF6 induced activity of the NF-kappa B pathway similar to the effect induced by IL-1, while the Ras(Val-12) induced activity was not inhibited by co-transfection with a dominant negative TRAF6.	val-12	26-32	TNF receptor associated factor 6	Homo sapiens	237-242
9388239-6	1997	Three Ha-ras transfectants and three Ki-ras transfectants exhibited Ras proteins expressing the Val-12 mutation by Western blotting with pan-rasG12V antibody.	val-12	96-102	KRAS proto-oncogene, GTPase	Homo sapiens	37-43
10896935-6	2000	Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not.	val-12	109-115	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	42-70
10896935-6	2000	Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not.	val-12	109-115	Harvey rat sarcoma virus oncogene	Mus musculus	102-108
10896935-6	2000	Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not.	val-12	109-115	CD44 antigen	Mus musculus	125-129
10896935-6	2000	Treatment with LY294002, an inhibitor for phosphoinositide 3-OH kinase (PI3K), significantly inhibits Ha-Ras(Val-12)-induced CD44 cleavage, whereas that with PD98059, an inhibitor for MEK, does not.	val-12	109-115	midkine	Mus musculus	184-187
10896935-8	2000	Moreover, the expression of dominant negative mutants of Cdc42 and Rac1 inhibits the Ha-Ras(Val-12)-induced CD44 cleavage.	val-12	92-98	cell division cycle 42	Mus musculus	57-62
10896935-8	2000	Moreover, the expression of dominant negative mutants of Cdc42 and Rac1 inhibits the Ha-Ras(Val-12)-induced CD44 cleavage.	val-12	92-98	Rac family small GTPase 1	Mus musculus	67-71
10896935-8	2000	Moreover, the expression of dominant negative mutants of Cdc42 and Rac1 inhibits the Ha-Ras(Val-12)-induced CD44 cleavage.	val-12	92-98	Harvey rat sarcoma virus oncogene	Mus musculus	85-91
10896935-8	2000	Moreover, the expression of dominant negative mutants of Cdc42 and Rac1 inhibits the Ha-Ras(Val-12)-induced CD44 cleavage.	val-12	92-98	CD44 antigen	Mus musculus	108-112
10722727-5	2000	In contrast, the ERK pathway-selective protein Ras(Val-12)T35S had no protective effects on NGF-deprived neurons but was almost as strongly protective as Ras(Val-12) against cytosine arabinoside-induced apoptosis.	val-12	51-57	mitogen-activated protein kinase 1	Homo sapiens	17-20
10722727-6	2000	The protective effects of Ras(Val-12)T35S against cytosine arabinoside were completely abolished by the ERK pathway inhibitor PD98059.	val-12	30-36	mitogen-activated protein kinase 1	Homo sapiens	104-107
10896935-4	2000	Here, we demonstrate that the expression of the dominant active mutant of Ha-Ras (Ha-Ras(Val-12)) induces redistribution of CD44 to the newly generated membrane ruffling area and CD44 ectodomain cleavage.	val-12	89-95	Harvey rat sarcoma virus oncogene	Mus musculus	74-80
10896935-4	2000	Here, we demonstrate that the expression of the dominant active mutant of Ha-Ras (Ha-Ras(Val-12)) induces redistribution of CD44 to the newly generated membrane ruffling area and CD44 ectodomain cleavage.	val-12	89-95	Harvey rat sarcoma virus oncogene	Mus musculus	82-88
10896935-4	2000	Here, we demonstrate that the expression of the dominant active mutant of Ha-Ras (Ha-Ras(Val-12)) induces redistribution of CD44 to the newly generated membrane ruffling area and CD44 ectodomain cleavage.	val-12	89-95	CD44 antigen	Mus musculus	124-128
10896935-4	2000	Here, we demonstrate that the expression of the dominant active mutant of Ha-Ras (Ha-Ras(Val-12)) induces redistribution of CD44 to the newly generated membrane ruffling area and CD44 ectodomain cleavage.	val-12	89-95	CD44 antigen	Mus musculus	179-183
10896935-5	2000	The migration assay revealed that the CD44 cleavage contributes to the Ha-Ras(Val-12)-induced migration of NIH3T3 cells on hyaluronate substrate.	val-12	78-84	CD44 antigen	Mus musculus	38-42
10896935-5	2000	The migration assay revealed that the CD44 cleavage contributes to the Ha-Ras(Val-12)-induced migration of NIH3T3 cells on hyaluronate substrate.	val-12	78-84	Harvey rat sarcoma virus oncogene	Mus musculus	71-77
10781597-5	2000	This is in contrast with a rat intestinal epithelial cell line in which induction of Ha-Ras(Val-12) results in transformation associated with sustained proliferation and increased levels of cyclin D1, that is not accompanied by anoikis or apoptosis.	val-12	92-98	cyclin D1	Rattus norvegicus	190-199
10781597-8	2000	Induction of Ha-Ras(Val-12) resulted in activation of Akt kinase and inactivation of glycogen-synthase-3beta kinase that are associated with reduction of cyclin D1 protein.	val-12	20-26	cyclin D1	Rattus norvegicus	154-163
7479845-2	1995	This effect is mediated by increased phosphorylation of JNK in the presence of wild-type and oncogenic (Val-12) p21 protein in a dose-dependent manner.	val-12	104-110	mitogen-activated protein kinase 8	Homo sapiens	56-59
7479845-2	1995	This effect is mediated by increased phosphorylation of JNK in the presence of wild-type and oncogenic (Val-12) p21 protein in a dose-dependent manner.	val-12	104-110	H3 histone pseudogene 16	Homo sapiens	112-115
1923528-4	1991	To test this hypothesis, we used ras-transformed NIH3T3 cells that express an activated p21 containing valine (Val-12 p21) at position 12 instead of the normal glycine (Gly-12 p21) and a monoclonal antibody (mAb) designated DWP that is specific for the activated Val-12 ras proteins.	val-12	111-117	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	88-91
8359224-9	1993	This concentration of TPEN totally blocked DNA synthesis both in control and c-Ha-ras(val-12)-expressing fibroblasts.	val-12	86-92	Harvey rat sarcoma virus oncogene	Mus musculus	77-85
8359224-12	1993	The results suggest that c-Ha-ras(val-12)-induced proliferation is independent of changes in [Ca2+]i.	val-12	34-40	Harvey rat sarcoma virus oncogene	Mus musculus	25-33
1923528-11	1991	This report is the first description of an activated ras protein (Val-12 p21) in the plasma of tumor-bearing mice and demonstrates that the results of the Val-12 p21-specific ELISA could be validated with Western blot format.	val-12	66-72	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	73-76
1923528-5	1991	Culture fluids collected from NIH3T3 cells transformed by the activated Val-12 p21 were shown, using mAb DWP in a sandwich ELISA format, to contain the activated Val-12 p21.	val-12	72-78	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	79-82
1923528-11	1991	This report is the first description of an activated ras protein (Val-12 p21) in the plasma of tumor-bearing mice and demonstrates that the results of the Val-12 p21-specific ELISA could be validated with Western blot format.	val-12	66-72	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	162-165
1923528-5	1991	Culture fluids collected from NIH3T3 cells transformed by the activated Val-12 p21 were shown, using mAb DWP in a sandwich ELISA format, to contain the activated Val-12 p21.	val-12	72-78	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	169-172
1923528-5	1991	Culture fluids collected from NIH3T3 cells transformed by the activated Val-12 p21 were shown, using mAb DWP in a sandwich ELISA format, to contain the activated Val-12 p21.	val-12	162-168	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	79-82
1923528-5	1991	Culture fluids collected from NIH3T3 cells transformed by the activated Val-12 p21 were shown, using mAb DWP in a sandwich ELISA format, to contain the activated Val-12 p21.	val-12	162-168	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	169-172
1923528-10	1991	Activated Val-12 p21 was not present in the plasma of non-tumor-bearing mice, or in the plasma of mice bearing SQ tumors composed of non-Val-12 p21 ras-transformed cells.	val-12	10-16	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	17-20
1657097-0	1991	Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.	val-12	14-20	neuron specific gene family member 1	Mus musculus	32-35
1652268-2	1991	Here we present evidence that c-Ha-ras (p21(Gly-12)) and its oncogenic mutant T24-ras (p21(Val-12)) selectively induce omega-conotoxin and dihydropyridine-sensitive Ca2+ currents within a few hours after introduction into the cytoplasm of neuroblastoma x glioma hybrid cells.	val-12	91-97	H3 histone pseudogene 16	Homo sapiens	40-43
1652268-2	1991	Here we present evidence that c-Ha-ras (p21(Gly-12)) and its oncogenic mutant T24-ras (p21(Val-12)) selectively induce omega-conotoxin and dihydropyridine-sensitive Ca2+ currents within a few hours after introduction into the cytoplasm of neuroblastoma x glioma hybrid cells.	val-12	91-97	H3 histone pseudogene 16	Homo sapiens	87-90
1652268-5	1991	In contrast, introduction of p21(Val-12) resulted in a prolonged delay (6 hours) of the effect which lasted for more than 24 hours.	val-12	33-39	H3 histone pseudogene 16	Homo sapiens	29-32
1657097-0	1991	Expression of val-12 mutant ras p21 in an IL-3-dependent murine myeloid cell line is associated with loss of serum-dependence and increases in membrane PIP2-specific phospholipase C activity.	val-12	14-20	interleukin 3	Mus musculus	42-46
1657097-7	1991	Thus serum-dependence and adenylate cyclase-mediated pertussis toxin-sensitivity of the parent cell line was bypassed by val-12 mutant ras p21, possibly as a result of increased PIP2-specific phospholipase C activity.	val-12	121-127	neuron specific gene family member 1	Mus musculus	139-142
2549949-0	1989	Scrape-loaded p21ras down-regulates agonist-stimulated inositol phosphate production by a mechanism involving protein kinase C. The effect of scrape-loaded [Val-12]p21ras on agonist-stimulated phosphatidylinositol 4,5-bisphosphate (PIP2) turnover in Swiss-3T3 cells was studied.	val-12	157-163	Harvey rat sarcoma virus oncogene	Mus musculus	14-20
2549949-0	1989	Scrape-loaded p21ras down-regulates agonist-stimulated inositol phosphate production by a mechanism involving protein kinase C. The effect of scrape-loaded [Val-12]p21ras on agonist-stimulated phosphatidylinositol 4,5-bisphosphate (PIP2) turnover in Swiss-3T3 cells was studied.	val-12	157-163	Harvey rat sarcoma virus oncogene	Mus musculus	164-170
3042464-3	1988	Previously, we reported that not only oncogenic p21(Val-12) but also proto-oncogenic p21(Gly-12) could induce morphological differentiation in rat pheochromocytoma PC12 cells when microinjected in the complexed form with GTP gamma S [(1987) Mol.	val-12	52-58	KRAS proto-oncogene, GTPase	Rattus norvegicus	48-51
3042464-10	1988	It was found that conditionally induced p21(Val-12) was mostly present in the GTP-bound form, whereas the endogenous p21(Gly-12) was in the GDP-bound form.	val-12	44-50	KRAS proto-oncogene, GTPase	Rattus norvegicus	40-43
3288862-8	1988	We found that cells expressing elevated levels of the normal p21(H-ras) could be fully transformed by the activated (Val-12) form and that such cells continued to overexpress p21(H-ras) (Gly-12), arguing against a role for normal ras genes in suppression of the oncogenic potential of their mutationally activated counterparts.	val-12	117-123	KRAS proto-oncogene, GTPase	Rattus norvegicus	61-64
3288862-8	1988	We found that cells expressing elevated levels of the normal p21(H-ras) could be fully transformed by the activated (Val-12) form and that such cells continued to overexpress p21(H-ras) (Gly-12), arguing against a role for normal ras genes in suppression of the oncogenic potential of their mutationally activated counterparts.	val-12	117-123	HRas proto-oncogene, GTPase	Rattus norvegicus	65-70