PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19546176-9	2010	The ex vivo study showed significantly (p<0.05) decreased platelet adhesion and P-selectin expression after administration of ioversol and iodixanol.	ioversol	129-137	selectin P	Homo sapiens	83-93
23485664-11	2013	Significantly increased apoptosis and caspase-3 protein expression were observed in the NRK-52E cells exposed to ioversol for 4 h. Ioversol treatment induced a significant increase in [Ca(2+)](i) and intracellular ROS.	ioversol	113-121	caspase 3	Rattus norvegicus	38-47
23485664-11	2013	Significantly increased apoptosis and caspase-3 protein expression were observed in the NRK-52E cells exposed to ioversol for 4 h. Ioversol treatment induced a significant increase in [Ca(2+)](i) and intracellular ROS.	ioversol	131-139	caspase 3	Rattus norvegicus	38-47
23485664-12	2013	KB-R7943 dose-dependently and significantly suppressed the increase in [Ca(2+)](i), intracellular ROS and caspase-3 overexpression induced by ioversol and attenuated the contrast-induced NRK-52E cell apoptosis.	ioversol	142-150	caspase 3	Rattus norvegicus	106-115
19546176-11	2010	The in vitro study showed that ioversol, iodixanol and ioxaglate significantly (p<0.05) and dose-dependently (beginning at 3 mg ml(-1)) decreased platelet adhesion and P-selectin expression.	ioversol	31-39	selectin P	Homo sapiens	171-181
19546176-13	2010	In conclusion, ioversol, iodixanol and ioxaglate inhibit platelet adhesion and P-selectin expression, as well as plasma coagulation.	ioversol	15-23	selectin P	Homo sapiens	79-89
15855635-8	2005	In mice with unilateral renal occlusion, ioversol increased urinary excretion of N-acetyl-beta-d-glucosaminidase with concomitant decreases in Bcl-2 mRNA, increases in Bax mRNA, activation of caspase-3, and induction of apoptosis in tubular and interstitial cells.	ioversol	41-49	B cell leukemia/lymphoma 2	Mus musculus	143-148
16828304-16	2006	Furthermore, ioversol induced a decrease in the expression for bcl-2 mRNA and an increase for bax mRNA.	ioversol	13-21	BCL2, apoptosis regulator	Rattus norvegicus	63-68
16828304-16	2006	Furthermore, ioversol induced a decrease in the expression for bcl-2 mRNA and an increase for bax mRNA.	ioversol	13-21	BCL2 associated X, apoptosis regulator	Rattus norvegicus	94-97
16828304-18	2006	In addition, irbesartan reversed the ioversol-induced increase in bax mRNA and decrease in bcl-2 mRNA.	ioversol	37-45	BCL2 associated X, apoptosis regulator	Rattus norvegicus	66-69
16828304-18	2006	In addition, irbesartan reversed the ioversol-induced increase in bax mRNA and decrease in bcl-2 mRNA.	ioversol	37-45	BCL2, apoptosis regulator	Rattus norvegicus	91-96
16828304-19	2006	CONCLUSION: Ioversol induced NRK-52E cells apoptosis in a concentration- and time-dependant manner via an increase in oxidative stress and subsequent to the increase in mRNA expression for bax and reduction in bcl-2 mRNA.	ioversol	12-20	BCL2 associated X, apoptosis regulator	Rattus norvegicus	189-192
16828304-19	2006	CONCLUSION: Ioversol induced NRK-52E cells apoptosis in a concentration- and time-dependant manner via an increase in oxidative stress and subsequent to the increase in mRNA expression for bax and reduction in bcl-2 mRNA.	ioversol	12-20	BCL2, apoptosis regulator	Rattus norvegicus	210-215
16828304-20	2006	Irbesartan attenuated the ioversol-induced apoptosis in NRK-52E cells by reducing oxidative stress and reversing the enhancement of bax mRNA and the reduction in bcl-2 mRNA.	ioversol	26-34	BCL2 associated X, apoptosis regulator	Rattus norvegicus	132-135
16828304-20	2006	Irbesartan attenuated the ioversol-induced apoptosis in NRK-52E cells by reducing oxidative stress and reversing the enhancement of bax mRNA and the reduction in bcl-2 mRNA.	ioversol	26-34	BCL2, apoptosis regulator	Rattus norvegicus	162-167
16408118-9	2006	FB(1) reversed ioversol-induced decrease in the immunoreactivities of pAkt and pCREB, reduction in Bcl-2 expression and caspase-3 activation.	ioversol	15-23	B cell leukemia/lymphoma 2	Mus musculus	99-104
16408118-9	2006	FB(1) reversed ioversol-induced decrease in the immunoreactivities of pAkt and pCREB, reduction in Bcl-2 expression and caspase-3 activation.	ioversol	15-23	caspase 3	Mus musculus	120-129
16408118-10	2006	Like ioversol, C2 ceramide and the Akt inhibitor Src homology-6 induced apoptosis by reducing pAkt and pCREB-like immunoreactivities, lowering Bcl-2 expression and enhancing caspase-3 activity.	ioversol	5-13	B cell leukemia/lymphoma 2	Mus musculus	143-148
16408118-10	2006	Like ioversol, C2 ceramide and the Akt inhibitor Src homology-6 induced apoptosis by reducing pAkt and pCREB-like immunoreactivities, lowering Bcl-2 expression and enhancing caspase-3 activity.	ioversol	5-13	caspase 3	Mus musculus	174-183
15855635-8	2005	In mice with unilateral renal occlusion, ioversol increased urinary excretion of N-acetyl-beta-d-glucosaminidase with concomitant decreases in Bcl-2 mRNA, increases in Bax mRNA, activation of caspase-3, and induction of apoptosis in tubular and interstitial cells.	ioversol	41-49	BCL2-associated X protein	Mus musculus	168-171
15855635-8	2005	In mice with unilateral renal occlusion, ioversol increased urinary excretion of N-acetyl-beta-d-glucosaminidase with concomitant decreases in Bcl-2 mRNA, increases in Bax mRNA, activation of caspase-3, and induction of apoptosis in tubular and interstitial cells.	ioversol	41-49	caspase 3	Mus musculus	192-201
9716151-9	1998	Contrast agents inhibited binding of thrombin to fibrin, with ionic agents producing a more potent effect than ioversol (p <0.02).	ioversol	111-119	coagulation factor II, thrombin	Homo sapiens	37-45
15855635-3	2005	Ioversol, a radiocontrast medium, caused cell injury accompanied by decreases in Bcl-2, increases in Bax, and caspase activation in LLC-PK1 cells.	ioversol	0-8	apoptosis regulator Bcl-2	Sus scrofa	81-86
15855635-3	2005	Ioversol, a radiocontrast medium, caused cell injury accompanied by decreases in Bcl-2, increases in Bax, and caspase activation in LLC-PK1 cells.	ioversol	0-8	apoptosis regulator BAX	Sus scrofa	101-104
15086904-10	2004	In addition, beraprost sodium reversed the ioversol-induced increase in bax mRNA with a concomitant decrease in bcl-2 mRNA and subsequent activation of caspase-3 and -9, thereby resulting in the inhibition of the nuclear damage.	ioversol	43-51	apoptosis regulator BAX	Sus scrofa	72-75
15086904-10	2004	In addition, beraprost sodium reversed the ioversol-induced increase in bax mRNA with a concomitant decrease in bcl-2 mRNA and subsequent activation of caspase-3 and -9, thereby resulting in the inhibition of the nuclear damage.	ioversol	43-51	apoptosis regulator Bcl-2	Sus scrofa	112-117
15086904-10	2004	In addition, beraprost sodium reversed the ioversol-induced increase in bax mRNA with a concomitant decrease in bcl-2 mRNA and subsequent activation of caspase-3 and -9, thereby resulting in the inhibition of the nuclear damage.	ioversol	43-51	caspase 3	Sus scrofa	152-168
14633127-10	2003	The cell damage induced by a non-ionic contrast medium ioversol was inhibited by specific inhibitors for caspase-3 and -9 but not caspase-8.	ioversol	55-63	caspase 3	Sus scrofa	105-121
14633127-11	2003	Ioversol enhanced the activities of caspase-3 and -9, but to a lesser extent, caspase-8.	ioversol	0-8	caspase 3	Sus scrofa	36-52
14633127-11	2003	Ioversol enhanced the activities of caspase-3 and -9, but to a lesser extent, caspase-8.	ioversol	0-8	caspase 8	Sus scrofa	78-87
14633127-12	2003	The bax mRNA was enhanced, while bcl-2 mRNA was reduced, after exposure to ioversol.	ioversol	75-83	apoptosis regulator BAX	Sus scrofa	4-7
14633127-12	2003	The bax mRNA was enhanced, while bcl-2 mRNA was reduced, after exposure to ioversol.	ioversol	75-83	apoptosis regulator Bcl-2	Sus scrofa	33-38
10548377-10	1999	Bradykinin (10(-6) M) significantly increased permeability to albumin, ioversol, and sinerem.	ioversol	71-79	kininogen 1	Homo sapiens	0-10
9061418-3	1996	The urinary NAG to creatinine ratio tended to increase after respective contrast media: 5% increase in the ioversol-treated, and 8% in the iohexol-treated patients.	ioversol	107-115	O-GlcNAcase	Homo sapiens	12-15
7738783-2	1995	All contrast media, including ionic (iothalamate and ioxaglate) and non-ionic ones (iohexol, ioversol and iopamidol), suppressed the collagen- and thrombin-induced aggregation in a concentration-dependent manner.	ioversol	93-101	coagulation factor II, thrombin	Homo sapiens	147-155
23283135-4	2013	We produced a long-acting form of Trx as a recombinant human albumin-Trx fusion protein (HSA-Trx) and examined its effectiveness in preventing renal injury in a rat model of ioversol-induced CIN.	ioversol	174-182	thioredoxin	Homo sapiens	34-37
7710450-1	1995	In the present series of studies we investigated differences in vitro and in animal experiments between iopamidol (Iopamiron, CAS 60166-93-0) and ioversol (CAS 87771-40-2).	ioversol	146-154	BCAR1 scaffold protein, Cas family member	Homo sapiens	156-159
2296655-5	1990	The authors conclude that this difference presents a novel hazard in that iopamidol, iohexol, and ioversol permit thrombin generation to occur while inhibiting the fibrin polymerization step of blood coagulation, thus posing a significant, albeit theoretical, threat to patient well-being.	ioversol	98-106	coagulation factor II, thrombin	Homo sapiens	114-122
28540295-11	2017	Ioversol reduced the viability of HK-2 cells.	ioversol	0-8	hexokinase 2	Homo sapiens	34-38
28540295-12	2017	Western blotting results revealed decreased expression of phosphorylated Akt in cells treated with ioversol.	ioversol	99-107	AKT serine/threonine kinase 1	Homo sapiens	73-76
28540295-14	2017	As a result, the Bax/Bcl-2 ratio increased after treatment with ioversol.	ioversol	64-72	BCL2 associated X, apoptosis regulator	Homo sapiens	17-20
28540295-14	2017	As a result, the Bax/Bcl-2 ratio increased after treatment with ioversol.	ioversol	64-72	BCL2 apoptosis regulator	Homo sapiens	21-26
9419457-6	1994	NAG levels increased from baseline for both diatrizoate meglumine- and ioversol-treated animals (from 83.9 +/- 48.6 to 145.5 +/- 55.4 and from 69.41 +/- 43.6 to 123.1 +/- 50.7, respectively; P < 0.05 from baseline for ioversol) and declined in other groups.	ioversol	71-79	O-GlcNAcase	Rattus norvegicus	0-3
9419457-6	1994	NAG levels increased from baseline for both diatrizoate meglumine- and ioversol-treated animals (from 83.9 +/- 48.6 to 145.5 +/- 55.4 and from 69.41 +/- 43.6 to 123.1 +/- 50.7, respectively; P < 0.05 from baseline for ioversol) and declined in other groups.	ioversol	221-229	O-GlcNAcase	Rattus norvegicus	0-3
33387208-10	2021	In the rat CIN model, Ioversol induced kidney morphology changes, with increase on SCr and BUN contents, elevated levels of inflammatory cytokines and upregulated expressions of XIST, NLRP3, ASC and Cleaved caspase-1.	ioversol	22-30	uncharacterized LOC100911498	Rattus norvegicus	178-182
33387208-10	2021	In the rat CIN model, Ioversol induced kidney morphology changes, with increase on SCr and BUN contents, elevated levels of inflammatory cytokines and upregulated expressions of XIST, NLRP3, ASC and Cleaved caspase-1.	ioversol	22-30	NLR family, pyrin domain containing 3	Rattus norvegicus	184-189
33387208-10	2021	In the rat CIN model, Ioversol induced kidney morphology changes, with increase on SCr and BUN contents, elevated levels of inflammatory cytokines and upregulated expressions of XIST, NLRP3, ASC and Cleaved caspase-1.	ioversol	22-30	PYD and CARD domain containing	Rattus norvegicus	191-194
33387208-11	2021	Silencing XIST reversed the effects of Ioversol on cells.	ioversol	39-47	uncharacterized LOC100911498	Rattus norvegicus	10-14
33387208-12	2021	MiR-133a-3p could bind with XIST and target NLRP3, and downregulating miR-133a-3p reversed the effect of silencing XIST on Ioversol-treated cells.	ioversol	123-131	uncharacterized LOC100911498	Rattus norvegicus	28-32
33387208-12	2021	MiR-133a-3p could bind with XIST and target NLRP3, and downregulating miR-133a-3p reversed the effect of silencing XIST on Ioversol-treated cells.	ioversol	123-131	NLR family, pyrin domain containing 3	Rattus norvegicus	44-49
33387208-12	2021	MiR-133a-3p could bind with XIST and target NLRP3, and downregulating miR-133a-3p reversed the effect of silencing XIST on Ioversol-treated cells.	ioversol	123-131	uncharacterized LOC100911498	Rattus norvegicus	115-119
33299530-11	2020	Ioversol injection induced high expression levels of the mitophagy markers Pink1, Parkin, and LC3 and the senescence markers beta-galactosidase and p16INK4A.	ioversol	0-8	PTEN induced kinase 1	Rattus norvegicus	75-80
33299530-11	2020	Ioversol injection induced high expression levels of the mitophagy markers Pink1, Parkin, and LC3 and the senescence markers beta-galactosidase and p16INK4A.	ioversol	0-8	annexin A3	Rattus norvegicus	94-97
33299530-11	2020	Ioversol injection induced high expression levels of the mitophagy markers Pink1, Parkin, and LC3 and the senescence markers beta-galactosidase and p16INK4A.	ioversol	0-8	galactosidase, beta 1	Rattus norvegicus	125-143
33299530-11	2020	Ioversol injection induced high expression levels of the mitophagy markers Pink1, Parkin, and LC3 and the senescence markers beta-galactosidase and p16INK4A.	ioversol	0-8	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	148-156
33299530-13	2020	Cellular morphological changes were found, and expression of LC3B and HMGB1 was increased by ioversol in HK-2 cells.	ioversol	93-101	high mobility group box 1	Rattus norvegicus	70-75
30955191-0	2019	Dynamic Effects of Ioversol on the Permeability of the Blood-Brain Barrier and the Expression of ZO-1/Occludin in Rats.	ioversol	19-27	occludin	Rattus norvegicus	102-110
30955191-7	2019	Occludin was similar, but its lowest expression appeared at 0.5 h. This study demonstrated that the permeability of BBB in rats increased first and then decreased after ioversol was injected into the carotid artery.	ioversol	169-177	occludin	Rattus norvegicus	0-8
27898408-12	2016	Sulodexide pretreatment protected HK2 cells against the cytotoxicity of Ioversol via inhibiting caspase-3 activity.	ioversol	72-80	caspase 3	Rattus norvegicus	96-105
25635854-9	2015	Furthermore, renalase protected HK2 cells against the cytotoxicity of Ioversol and suppressed Caspase-3 activity, oxidative stress and apoptosis induced by H2O2.	ioversol	70-78	renalase, FAD-dependent amine oxidase	Rattus norvegicus	13-21