PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17896945-7	2007	The relative affinities of hydroxycamptothecins to HSA and model membranes in the form of DMPC liposomes were determined, and DB-67 exhibited the most desirable properties including the highest affinity to membranes in its lactone form and low affinity to HSA in its carboxylate form.	hydroxycamptothecinum	27-47	albumin	Homo sapiens	51-54
17033717-0	2006	Bcl-XL small interfering RNA enhances sensitivity of Hepg2 hepatocellular carcinoma cells to 5-fluorouracil and hydroxycamptothecin.	hydroxycamptothecinum	112-131	BCL2 like 1	Homo sapiens	0-6
17291037-5	2007	A pH-sensitive anticancer agent, hydroxycamptothecin (HCPT), was encapsulated in ALG-PDEA nanoparticles, and preliminary in vitro release as well as cytotoxicity experiments were carried out.	hydroxycamptothecinum	33-52	phosphodiesterase 6A	Homo sapiens	85-89
17291037-5	2007	A pH-sensitive anticancer agent, hydroxycamptothecin (HCPT), was encapsulated in ALG-PDEA nanoparticles, and preliminary in vitro release as well as cytotoxicity experiments were carried out.	hydroxycamptothecinum	54-58	phosphodiesterase 6A	Homo sapiens	85-89
17033717-8	2006	Flow cytometry (FCM) results demonstrated that the sub-G1 population increased in the Bcl-XL siRNA group, compared with the negative siRNA group and untreated control group, after the addition of 5-FU (1300 mg/L) and HCPT (0.72 mg/L).	hydroxycamptothecinum	217-221	BCL2 like 1	Homo sapiens	86-92
17033717-9	2006	siRNA targeting Bcl-XL gene can specifically down-regulate Bcl-XL expression in Hepg2 cells, and can increase spontaneous cell apoptosis and sensitize cells to 5-FU or HCPT.	hydroxycamptothecinum	168-172	BCL2 like 1	Homo sapiens	16-22
12703990-3	2003	This study was designed to investigate the experimental therapeutic effect of the combination of topoisomerase I inhibitor hydroxycamptothecin (HCPT) with topoisomerase II inhibitor etoposide (VP-16) on nasopharyngeal carcinoma (NPC), the effect of the combination of HCPT with VP-16 against NPC was studied in vitro and in vivo.	hydroxycamptothecinum	123-142	host cell factor C1	Homo sapiens	278-283
16926123-8	2006	However, when cells were treated with HCPT, the massive translocation of cytochrome c and AIF to the nucleus was evident.	hydroxycamptothecinum	38-42	cytochrome c, somatic	Homo sapiens	73-85
16926123-8	2006	However, when cells were treated with HCPT, the massive translocation of cytochrome c and AIF to the nucleus was evident.	hydroxycamptothecinum	38-42	apoptosis inducing factor mitochondria associated 1	Homo sapiens	90-93
16926123-10	2006	Mitochondrial pathway of apoptosis, especially for cytochrome c and AIF translocation, may play an important role in apoptosis induced by HCPT.	hydroxycamptothecinum	138-142	cytochrome c, somatic	Homo sapiens	51-63
16926123-10	2006	Mitochondrial pathway of apoptosis, especially for cytochrome c and AIF translocation, may play an important role in apoptosis induced by HCPT.	hydroxycamptothecinum	138-142	apoptosis inducing factor mitochondria associated 1	Homo sapiens	68-71
15812674-2	2005	In the study reported here, we investigated HERG expression in various cancer cell lines, its correlation with chemosensitivity to vincristine, paclitaxel, and hydroxy-camptothecin, and its biochemical modulation.	hydroxycamptothecinum	160-180	potassium voltage-gated channel subfamily H member 2	Homo sapiens	44-48
15812674-7	2005	RESULTS: HERG expression levels differed widely between various human cancer cell lines and HT-29 cells expressing high levels of HERG were more sensitive than A549 cells expressing low levels of HERG to vincristine, paclitaxel, and hydroxy-camptothecin.	hydroxycamptothecinum	233-253	potassium voltage-gated channel subfamily H member 2	Homo sapiens	9-13
15812674-7	2005	RESULTS: HERG expression levels differed widely between various human cancer cell lines and HT-29 cells expressing high levels of HERG were more sensitive than A549 cells expressing low levels of HERG to vincristine, paclitaxel, and hydroxy-camptothecin.	hydroxycamptothecinum	233-253	potassium voltage-gated channel subfamily H member 2	Homo sapiens	130-134
15812674-7	2005	RESULTS: HERG expression levels differed widely between various human cancer cell lines and HT-29 cells expressing high levels of HERG were more sensitive than A549 cells expressing low levels of HERG to vincristine, paclitaxel, and hydroxy-camptothecin.	hydroxycamptothecinum	233-253	potassium voltage-gated channel subfamily H member 2	Homo sapiens	130-134
15812674-8	2005	In terms of IC50, the chemosensitivities of herg-transfected A549 cells to vincristine, paclitaxel and hydroxy-camptothecin were significantly increased.	hydroxycamptothecinum	103-123	potassium voltage-gated channel subfamily H member 2	Homo sapiens	44-48
15812674-14	2005	CONCLUSIONS: HERG expression levels and chemosensitivity were positively correlated for vincristine, paclitaxel, and hydroxy-camptothecin.	hydroxycamptothecinum	117-137	potassium voltage-gated channel subfamily H member 2	Homo sapiens	13-17
16635299-0	2006	[Effect of hydroxycamptothecin on apoptosis-inducing factor (AIF) expression and on AIF translocation in human hepatocellular cancer cell SMMC-7721].	hydroxycamptothecinum	11-30	apoptosis inducing factor mitochondria associated 1	Homo sapiens	34-59
16635299-0	2006	[Effect of hydroxycamptothecin on apoptosis-inducing factor (AIF) expression and on AIF translocation in human hepatocellular cancer cell SMMC-7721].	hydroxycamptothecinum	11-30	apoptosis inducing factor mitochondria associated 1	Homo sapiens	61-64
16635299-1	2006	OBJECTIVE: To study the effect of hydroxycamptothecin (HCPT) on apoptosis-inducing factor (AIF) expression and AIF translocation from mitochondria to the nucleus in human hepatocellular cancer cell SMMC-7721 during apoptosis.	hydroxycamptothecinum	34-53	apoptosis inducing factor mitochondria associated 1	Homo sapiens	64-89
16635299-1	2006	OBJECTIVE: To study the effect of hydroxycamptothecin (HCPT) on apoptosis-inducing factor (AIF) expression and AIF translocation from mitochondria to the nucleus in human hepatocellular cancer cell SMMC-7721 during apoptosis.	hydroxycamptothecinum	34-53	apoptosis inducing factor mitochondria associated 1	Homo sapiens	91-94
16635299-1	2006	OBJECTIVE: To study the effect of hydroxycamptothecin (HCPT) on apoptosis-inducing factor (AIF) expression and AIF translocation from mitochondria to the nucleus in human hepatocellular cancer cell SMMC-7721 during apoptosis.	hydroxycamptothecinum	55-59	apoptosis inducing factor mitochondria associated 1	Homo sapiens	64-89
16635299-1	2006	OBJECTIVE: To study the effect of hydroxycamptothecin (HCPT) on apoptosis-inducing factor (AIF) expression and AIF translocation from mitochondria to the nucleus in human hepatocellular cancer cell SMMC-7721 during apoptosis.	hydroxycamptothecinum	55-59	apoptosis inducing factor mitochondria associated 1	Homo sapiens	91-94
16635299-7	2006	However, cells treated with 80 mg/ml HCPT for 6 h or 12 h showed massive translocation of AIF into the nuclei.	hydroxycamptothecinum	37-41	apoptosis inducing factor mitochondria associated 1	Homo sapiens	90-93
12703990-3	2003	This study was designed to investigate the experimental therapeutic effect of the combination of topoisomerase I inhibitor hydroxycamptothecin (HCPT) with topoisomerase II inhibitor etoposide (VP-16) on nasopharyngeal carcinoma (NPC), the effect of the combination of HCPT with VP-16 against NPC was studied in vitro and in vivo.	hydroxycamptothecinum	144-148	host cell factor C1	Homo sapiens	278-283
12703990-3	2003	This study was designed to investigate the experimental therapeutic effect of the combination of topoisomerase I inhibitor hydroxycamptothecin (HCPT) with topoisomerase II inhibitor etoposide (VP-16) on nasopharyngeal carcinoma (NPC), the effect of the combination of HCPT with VP-16 against NPC was studied in vitro and in vivo.	hydroxycamptothecinum	268-272	host cell factor C1	Homo sapiens	193-198
33397415-0	2021	The role of activating transcription factor 6 in hydroxycamptothecin-induced fibroblast autophagy and apoptosis.	hydroxycamptothecinum	49-68	activating transcription factor 6	Homo sapiens	12-45
33397415-3	2021	This study aimed to investigate the role of activating transcription factor 6 (ATF-6) in the HCPT-induced inhibition of fibroblast viability.	hydroxycamptothecinum	93-97	activating transcription factor 6	Homo sapiens	44-77
33397415-3	2021	This study aimed to investigate the role of activating transcription factor 6 (ATF-6) in the HCPT-induced inhibition of fibroblast viability.	hydroxycamptothecinum	93-97	activating transcription factor 6	Homo sapiens	79-84
33397415-7	2021	As a result, ATF6-mediated ERS played a role in HCPT-induced fibroblast apoptosis.	hydroxycamptothecinum	48-52	activating transcription factor 6	Homo sapiens	13-17
12934351-1	2003	OBJECTIVES: To study the change of caspase-3 activity on the neoadjuvant chemotherapy-induced apoptosis by hydroxycamptothecin (HCPT) with 5-fluorouracil (5-Fu)/leucovorin (CF) in large-intestinal carcinoma, and to explore its mechanism.	hydroxycamptothecinum	107-126	caspase 3	Homo sapiens	35-44
12934351-1	2003	OBJECTIVES: To study the change of caspase-3 activity on the neoadjuvant chemotherapy-induced apoptosis by hydroxycamptothecin (HCPT) with 5-fluorouracil (5-Fu)/leucovorin (CF) in large-intestinal carcinoma, and to explore its mechanism.	hydroxycamptothecinum	128-132	caspase 3	Homo sapiens	35-44
12631623-6	2003	RESULTS: In a synergistic fashion, Gem231 and HCPT induced growth arrest, apoptosis, and changes in cell morphology; down-regulated RIalpha expression; down-regulated Bcl-2 and promoted its hyperphosphorylation; up-regulated the proapoptotic proteins Bax and Bad; and promoted hypophosphorylation of Bad.	hydroxycamptothecinum	46-50	BCL2 apoptosis regulator	Homo sapiens	167-172
12631623-6	2003	RESULTS: In a synergistic fashion, Gem231 and HCPT induced growth arrest, apoptosis, and changes in cell morphology; down-regulated RIalpha expression; down-regulated Bcl-2 and promoted its hyperphosphorylation; up-regulated the proapoptotic proteins Bax and Bad; and promoted hypophosphorylation of Bad.	hydroxycamptothecinum	46-50	BCL2 associated X, apoptosis regulator	Homo sapiens	251-254
11776054-4	2000	RESULTS: The AFP secretion of HCPT-treated cells was reduced by 44.0%-49.2% while the ALB level was increased markedly.	hydroxycamptothecinum	30-34	albumin	Homo sapiens	86-89
10363568-2	1999	The aim of this work was to investigate the role of p53 in the apoptosis of colorectal cancer cells in vitro, induced by 5-fluorouracil (5-FU) and hydroxy-camptothecin (HCPT).	hydroxycamptothecinum	147-167	tumor protein p53	Homo sapiens	52-55
10363568-2	1999	The aim of this work was to investigate the role of p53 in the apoptosis of colorectal cancer cells in vitro, induced by 5-fluorouracil (5-FU) and hydroxy-camptothecin (HCPT).	hydroxycamptothecinum	169-173	tumor protein p53	Homo sapiens	52-55
32350965-4	2020	The in vitro and in vivo results further demonstrated that integrin beta8 overexpression in Biu87/T24 bladder cancer could mediate strengthen cells proliferation and resistance to mitomycin C and hydroxycamptothecin.	hydroxycamptothecinum	196-215	integrin subunit beta 8	Homo sapiens	59-73
31990625-7	2020	Verapamil may exert this effect through inhibiting the activity of CYP3A4 or P-gp, which are related to the metabolism and transport of HCPT.	hydroxycamptothecinum	136-140	phosphoglycolate phosphatase	Rattus norvegicus	77-81
30690843-6	2019	In terms of mechanism, we pretreated fibroblasts with the endoplasmic reticulum stress (ER) inhibitor salubrinal and RNA-dependent protein kinase-like ER kinase (PERK) short hairpin RNA, these treatments abolished the inhibitory effects of HCPT on fibrosis, thereby suggesting that HCPT"s inhibition of TGF-beta1-induced tendon fibrosis might be mediated by the PERK signaling pathway in vitro.	hydroxycamptothecinum	240-244	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	362-366
32280220-0	2020	Preparation, Characterization, and in vivo Evaluation of NK4-Conjugated Hydroxycamptothecin-Loaded Liposomes.	hydroxycamptothecinum	72-91	interleukin 32	Homo sapiens	57-60
32280220-1	2020	Purpose: In this study, NK4-conjugated hydroxycamptothecin liposomes (NK4-HCPT-Lips) were prepared with the aim of improving drug targeting to the liver.	hydroxycamptothecinum	39-58	interleukin 32	Homo sapiens	24-27
32280220-1	2020	Purpose: In this study, NK4-conjugated hydroxycamptothecin liposomes (NK4-HCPT-Lips) were prepared with the aim of improving drug targeting to the liver.	hydroxycamptothecinum	39-58	interleukin 32	Homo sapiens	70-73
30690843-5	2019	In addition, HCPT treatment also inhibited expression of fibrosis genes COL3A1 and alpha-smooth muscle actin (alpha-SMA).	hydroxycamptothecinum	13-17	collagen type III alpha 1 chain	Homo sapiens	72-78
31063955-7	2019	RESULTS: The flow cytometry and western blot results indicated that compared to TPL or HCPT treatment alone, combination treatment of HCPT and TPL significantly induced cell cycle arrest at the G1 phase via suppressing CDK4, CDK6 and CyclinD1 in the EJ and UMUC3 bladder cancer cell lines.	hydroxycamptothecinum	134-138	cyclin dependent kinase 4	Homo sapiens	219-223
31063955-7	2019	RESULTS: The flow cytometry and western blot results indicated that compared to TPL or HCPT treatment alone, combination treatment of HCPT and TPL significantly induced cell cycle arrest at the G1 phase via suppressing CDK4, CDK6 and CyclinD1 in the EJ and UMUC3 bladder cancer cell lines.	hydroxycamptothecinum	134-138	cyclin dependent kinase 6	Homo sapiens	225-229
31063955-7	2019	RESULTS: The flow cytometry and western blot results indicated that compared to TPL or HCPT treatment alone, combination treatment of HCPT and TPL significantly induced cell cycle arrest at the G1 phase via suppressing CDK4, CDK6 and CyclinD1 in the EJ and UMUC3 bladder cancer cell lines.	hydroxycamptothecinum	134-138	cyclin D1	Homo sapiens	234-242
31063955-8	2019	HCPT and TPL combination treatment also significantly increased the apoptosis rate and apoptosis-related protein levels (Caspase8 and Bcl-xl).	hydroxycamptothecinum	0-4	caspase 8	Homo sapiens	121-129
31063955-8	2019	HCPT and TPL combination treatment also significantly increased the apoptosis rate and apoptosis-related protein levels (Caspase8 and Bcl-xl).	hydroxycamptothecinum	0-4	BCL2 like 1	Homo sapiens	134-140
31063955-9	2019	Levels of the AKT pathway-related proteins AKT/p-AKT were significantly lower in EJ and UMUC3 cells treated with TPL and UMUC3 than in those cells treated with TPL or HCPT alone.	hydroxycamptothecinum	167-171	AKT serine/threonine kinase 1	Homo sapiens	14-17
31063955-9	2019	Levels of the AKT pathway-related proteins AKT/p-AKT were significantly lower in EJ and UMUC3 cells treated with TPL and UMUC3 than in those cells treated with TPL or HCPT alone.	hydroxycamptothecinum	167-171	AKT serine/threonine kinase 1	Homo sapiens	43-46
31063955-9	2019	Levels of the AKT pathway-related proteins AKT/p-AKT were significantly lower in EJ and UMUC3 cells treated with TPL and UMUC3 than in those cells treated with TPL or HCPT alone.	hydroxycamptothecinum	167-171	AKT serine/threonine kinase 1	Homo sapiens	43-46
30690843-6	2019	In terms of mechanism, we pretreated fibroblasts with the endoplasmic reticulum stress (ER) inhibitor salubrinal and RNA-dependent protein kinase-like ER kinase (PERK) short hairpin RNA, these treatments abolished the inhibitory effects of HCPT on fibrosis, thereby suggesting that HCPT"s inhibition of TGF-beta1-induced tendon fibrosis might be mediated by the PERK signaling pathway in vitro.	hydroxycamptothecinum	240-244	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	131-160
30191636-6	2018	In addition to taxol, reducing KIF20B also enhanced the toxicity of two chemotherapeutic drugs, hydroxycamptothecin and mitomycin C.	hydroxycamptothecinum	96-115	kinesin family member 20B	Homo sapiens	31-37
30690843-6	2019	In terms of mechanism, we pretreated fibroblasts with the endoplasmic reticulum stress (ER) inhibitor salubrinal and RNA-dependent protein kinase-like ER kinase (PERK) short hairpin RNA, these treatments abolished the inhibitory effects of HCPT on fibrosis, thereby suggesting that HCPT"s inhibition of TGF-beta1-induced tendon fibrosis might be mediated by the PERK signaling pathway in vitro.	hydroxycamptothecinum	240-244	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	162-166
30690843-6	2019	In terms of mechanism, we pretreated fibroblasts with the endoplasmic reticulum stress (ER) inhibitor salubrinal and RNA-dependent protein kinase-like ER kinase (PERK) short hairpin RNA, these treatments abolished the inhibitory effects of HCPT on fibrosis, thereby suggesting that HCPT"s inhibition of TGF-beta1-induced tendon fibrosis might be mediated by the PERK signaling pathway in vitro.	hydroxycamptothecinum	240-244	transforming growth factor beta 1	Homo sapiens	303-312
30802495-0	2019	CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.	hydroxycamptothecinum	82-101	cyclin dependent kinase like 1	Homo sapiens	0-5
30802495-3	2019	Here, we explored the role of CDKL1 in the chemoresistance of the human OSCC cell line CAL27 to hydroxycamptothecin (HCPT).	hydroxycamptothecinum	96-115	cyclin dependent kinase like 1	Homo sapiens	30-35
30802495-4	2019	Real-time quantitative polymerase chain reaction and western blotting revealed that exposure of CAL27 cells to HCPT led to a marked increase in the expression of CDKL1 at the mRNA and protein levels.	hydroxycamptothecinum	111-115	cyclin dependent kinase like 1	Homo sapiens	162-167
30802495-7	2019	After treatment with HCPT, whereas CDKL1 overexpression increased the resistance to HCPT of the remaining cells.	hydroxycamptothecinum	84-88	cyclin dependent kinase like 1	Homo sapiens	35-40
30802495-9	2019	Furthermore, CDKL1 overexpression partially reversed the inhibitory effects of HCPT in CAL27 cells.	hydroxycamptothecinum	79-83	cyclin dependent kinase like 1	Homo sapiens	13-18
30802495-10	2019	These results suggest that CDKL1 overexpression decreased the chemosensitivity of OSCC cells to HCPT, indicating a potential strategic approach for reversing the HCPT resistance in human OSCC.	hydroxycamptothecinum	96-100	cyclin dependent kinase like 1	Homo sapiens	27-32
30802495-10	2019	These results suggest that CDKL1 overexpression decreased the chemosensitivity of OSCC cells to HCPT, indicating a potential strategic approach for reversing the HCPT resistance in human OSCC.	hydroxycamptothecinum	162-166	cyclin dependent kinase like 1	Homo sapiens	27-32
29944107-7	2018	Furthermore, ZO-1, F-actin and claudin-4, known as three cellular tight junction proteins, were obvious down-regulation, which suggested that HCPT-loaded nanocochleates could open cellular tight junctions and paracellular route.	hydroxycamptothecinum	142-146	tight junction protein 1	Homo sapiens	13-17
26045770-10	2015	HCPT treatment induced the upregulation of CHOP and downregulation of XIAP in HTCFs.	hydroxycamptothecinum	0-4	DNA damage inducible transcript 3	Homo sapiens	43-47
29944107-7	2018	Furthermore, ZO-1, F-actin and claudin-4, known as three cellular tight junction proteins, were obvious down-regulation, which suggested that HCPT-loaded nanocochleates could open cellular tight junctions and paracellular route.	hydroxycamptothecinum	142-146	claudin 4	Homo sapiens	31-40
28781650-7	2017	Western blot analysis revealed that MMC and HCPT enhanced the E1A expression of the Ad5-UPII-E1A vectorin a dose-dependent manner.	hydroxycamptothecinum	44-48	Alzheimer disease, familial, type 5	Homo sapiens	84-87
28781650-7	2017	Western blot analysis revealed that MMC and HCPT enhanced the E1A expression of the Ad5-UPII-E1A vectorin a dose-dependent manner.	hydroxycamptothecinum	44-48	uroplakin 2	Homo sapiens	88-92
28781650-8	2017	The present study demonstrated that Ad5-UPII-E1A combined with MMC or HCPT resulted in synergistic cytotoxicity in a process which involved the promotion of apoptosis in bladder cancer cell lines.	hydroxycamptothecinum	70-74	uroplakin 2	Homo sapiens	40-44
28781650-9	2017	MMC and HCPT also promoted the oncolytic effect of Ad5-UPII-E1A.	hydroxycamptothecinum	8-12	Alzheimer disease, familial, type 5	Homo sapiens	51-54
28781650-9	2017	MMC and HCPT also promoted the oncolytic effect of Ad5-UPII-E1A.	hydroxycamptothecinum	8-12	uroplakin 2	Homo sapiens	55-59
27005157-0	2015	RGDC functionalized and hydroxycamptothecin-encapsulated magnetic nanohybrids for integrin alphaVbeta3-targeted drug delivery.	hydroxycamptothecinum	24-43	integrin subunit alpha V	Homo sapiens	82-102
25966236-0	2015	Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis.	hydroxycamptothecinum	11-30	matrix metallopeptidase 1	Rattus norvegicus	52-78
25966236-0	2015	Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis.	hydroxycamptothecinum	11-30	matrix metallopeptidase 1	Rattus norvegicus	80-85
25966236-0	2015	Effects of hydroxycamptothecin on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1, and type I collagen in rats with pulmonary fibrosis.	hydroxycamptothecinum	11-30	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	88-113
25966236-1	2015	The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5.	hydroxycamptothecinum	56-75	matrix metallopeptidase 1	Rattus norvegicus	104-130
25966236-1	2015	The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5.	hydroxycamptothecinum	56-75	matrix metallopeptidase 1	Rattus norvegicus	132-137
25966236-1	2015	The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5.	hydroxycamptothecinum	56-75	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	140-165
25966236-1	2015	The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5.	hydroxycamptothecinum	77-81	matrix metallopeptidase 1	Rattus norvegicus	104-130
25966236-1	2015	The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5.	hydroxycamptothecinum	77-81	matrix metallopeptidase 1	Rattus norvegicus	132-137
25966236-1	2015	The aim of this study was to investigate the effects of hydroxycamptothecin (HCPT) on the expression of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of MMP-1 (TIMP-1), and type I collagen in the lung tissue of rats with pulmonary fibrosis induced by bleomycin A5.	hydroxycamptothecinum	77-81	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	140-165
25966236-4	2015	After treatment with HCPT, the degree of pulmonary fibrosis and the expression of TIMP-1 and type I collagen decreased in all treatment groups.	hydroxycamptothecinum	21-25	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	82-108
28603046-0	2017	Hydroxycamptothecin prevents intraarticular scar adhesion by activating the PERK signal pathway.	hydroxycamptothecinum	0-19	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	76-80
28603046-3	2017	The aim of our experiment was to investigate the effect of topical application of HCPT on preventing intraarticular scar adhesion by activating the PERK signal pathway.	hydroxycamptothecinum	82-86	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	148-152
28603046-8	2017	HCPT-induced apoptosis was correlated with elevation of GRP78 and CHOP, which were hallmarks of ER stress.	hydroxycamptothecinum	0-4	heat shock protein family A (Hsp70) member 5	Homo sapiens	56-61
28603046-8	2017	HCPT-induced apoptosis was correlated with elevation of GRP78 and CHOP, which were hallmarks of ER stress.	hydroxycamptothecinum	0-4	DNA damage inducible transcript 3	Homo sapiens	66-70
28603046-9	2017	Proteins associated with PERK signal pathway such as p-PERK and p-eIF2alpha were upregulated after treated by HCPT determined by western blot analysis.	hydroxycamptothecinum	110-114	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	25-29
28603046-9	2017	Proteins associated with PERK signal pathway such as p-PERK and p-eIF2alpha were upregulated after treated by HCPT determined by western blot analysis.	hydroxycamptothecinum	110-114	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	55-59
28603046-10	2017	Knockdown of PERK decreased the ratio of Bax/Bcl-2, GRP78 and CHOP expression, suggesting that PERK signal pathway was involved in HCPT-induced fibroblast apoptosis.	hydroxycamptothecinum	131-135	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	13-17
28603046-10	2017	Knockdown of PERK decreased the ratio of Bax/Bcl-2, GRP78 and CHOP expression, suggesting that PERK signal pathway was involved in HCPT-induced fibroblast apoptosis.	hydroxycamptothecinum	131-135	BCL2 associated X, apoptosis regulator	Homo sapiens	41-44
28603046-10	2017	Knockdown of PERK decreased the ratio of Bax/Bcl-2, GRP78 and CHOP expression, suggesting that PERK signal pathway was involved in HCPT-induced fibroblast apoptosis.	hydroxycamptothecinum	131-135	BCL2 apoptosis regulator	Homo sapiens	45-50
28603046-10	2017	Knockdown of PERK decreased the ratio of Bax/Bcl-2, GRP78 and CHOP expression, suggesting that PERK signal pathway was involved in HCPT-induced fibroblast apoptosis.	hydroxycamptothecinum	131-135	heat shock protein family A (Hsp70) member 5	Homo sapiens	52-57
28603046-10	2017	Knockdown of PERK decreased the ratio of Bax/Bcl-2, GRP78 and CHOP expression, suggesting that PERK signal pathway was involved in HCPT-induced fibroblast apoptosis.	hydroxycamptothecinum	131-135	DNA damage inducible transcript 3	Homo sapiens	62-66
28603046-10	2017	Knockdown of PERK decreased the ratio of Bax/Bcl-2, GRP78 and CHOP expression, suggesting that PERK signal pathway was involved in HCPT-induced fibroblast apoptosis.	hydroxycamptothecinum	131-135	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	95-99
28781650-3	2017	The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells.	hydroxycamptothecinum	131-150	Alzheimer disease, familial, type 5	Homo sapiens	88-91
28781650-3	2017	The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells.	hydroxycamptothecinum	131-150	uroplakin 2	Homo sapiens	92-96
28781650-3	2017	The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells.	hydroxycamptothecinum	152-156	Alzheimer disease, familial, type 5	Homo sapiens	88-91
28781650-3	2017	The present study investigated whether this urothelium-specific recombinant adenovirus (Ad5-UPII-E1A) enhanced mitomycin (MMC) and hydroxycamptothecin (HCPT) sensitization and drug-induced apoptosis in bladder cancer cells.	hydroxycamptothecinum	152-156	uroplakin 2	Homo sapiens	92-96
28781650-6	2017	Treatment with MMC or HCPT enhanced Ad5-UPII-E1A-induced apoptosis in 5,637 cells, observed by transmission electron microscopy.	hydroxycamptothecinum	22-26	Alzheimer disease, familial, type 5	Homo sapiens	36-39
28781650-6	2017	Treatment with MMC or HCPT enhanced Ad5-UPII-E1A-induced apoptosis in 5,637 cells, observed by transmission electron microscopy.	hydroxycamptothecinum	22-26	uroplakin 2	Homo sapiens	40-44
27068147-7	2016	As the concentration of HCPT increased, the expressions of glucose-regulated protein 78 (GRP78), inositol-requiring kinase1 (IRE-1), C/EBP homologous protein (CHOP) and Bax were all increased, but the expression of Bcl-2 was decreased.	hydroxycamptothecinum	24-28	apoptosis regulator BAX	Oryctolagus cuniculus	169-172
27068147-7	2016	As the concentration of HCPT increased, the expressions of glucose-regulated protein 78 (GRP78), inositol-requiring kinase1 (IRE-1), C/EBP homologous protein (CHOP) and Bax were all increased, but the expression of Bcl-2 was decreased.	hydroxycamptothecinum	24-28	BCL-2	Oryctolagus cuniculus	215-220
27129905-0	2016	Pharmacokinetics and Tissue Distribution of Folate-Decorated Human Serum Albumin Loaded With Nano-Hydroxycamptothecin for Tumor Targeting.	hydroxycamptothecinum	98-117	albumin	Homo sapiens	73-80
26752212-8	2016	Analysis of cell cycle redistribution, apoptosis and expression of histone H2AX phosphorylation (lambda-H2AX) was used to evaluate the mechanism by which HCPT loaded micelles led to radiosensitization.	hydroxycamptothecinum	154-158	H2A.X variant histone	Homo sapiens	67-79
26752212-8	2016	Analysis of cell cycle redistribution, apoptosis and expression of histone H2AX phosphorylation (lambda-H2AX) was used to evaluate the mechanism by which HCPT loaded micelles led to radiosensitization.	hydroxycamptothecinum	154-158	H2A.X variant histone	Homo sapiens	75-79
26752212-9	2016	Taken together, the results showed that HCPT-loaded FA decorated micelles efficiently sensitized xenografts in mice to RT, and induced G2/M phase arrest, apoptosis and expression of lambda-H2AX.	hydroxycamptothecinum	40-44	H2A.X variant histone	Homo sapiens	189-193
26463633-0	2015	Has-miR-30a regulates autophagic activity in cervical cancer upon hydroxycamptothecin exposure.	hydroxycamptothecinum	66-85	microRNA 30a	Homo sapiens	4-11
26463633-6	2015	Futhermore, we showed that miR-30a could directly target a specific fragment in the 3" untranslated region of Beclin-1 as demonstrated by luciferase assay and overexpression of hsa-miR-30a by transfecting with miR-30a mimic could block HCPT-induced autophagic activity.	hydroxycamptothecinum	236-240	microRNA 30a	Homo sapiens	27-34
26463633-6	2015	Futhermore, we showed that miR-30a could directly target a specific fragment in the 3" untranslated region of Beclin-1 as demonstrated by luciferase assay and overexpression of hsa-miR-30a by transfecting with miR-30a mimic could block HCPT-induced autophagic activity.	hydroxycamptothecinum	236-240	beclin 1	Homo sapiens	110-118
25573072-0	2015	Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways.	hydroxycamptothecinum	42-61	protein phosphatase 2 phosphatase activator	Homo sapiens	139-143
25573072-0	2015	Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways.	hydroxycamptothecinum	42-61	mitogen-activated protein kinase 1	Homo sapiens	154-157
25573072-0	2015	Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways.	hydroxycamptothecinum	42-61	mitogen-activated protein kinase 14	Homo sapiens	159-162
25573072-0	2015	Combination treatment with triptolide and hydroxycamptothecin synergistically enhances apoptosis in A549 lung adenocarcinoma cells through PP2A-regulated ERK, p38 MAPKs and Akt signaling pathways.	hydroxycamptothecinum	42-61	AKT serine/threonine kinase 1	Homo sapiens	173-176
25573072-6	2015	Combinatorial TP/HCPT treatment significantly enhanced the activation of caspase-3 and -9, Bax/Bcl-2 ratio, release of cytochrome c from mitochondrial and subsequent apoptosis.	hydroxycamptothecinum	17-21	caspase 3	Homo sapiens	73-89
25573072-6	2015	Combinatorial TP/HCPT treatment significantly enhanced the activation of caspase-3 and -9, Bax/Bcl-2 ratio, release of cytochrome c from mitochondrial and subsequent apoptosis.	hydroxycamptothecinum	17-21	BCL2 associated X, apoptosis regulator	Homo sapiens	91-94
25573072-6	2015	Combinatorial TP/HCPT treatment significantly enhanced the activation of caspase-3 and -9, Bax/Bcl-2 ratio, release of cytochrome c from mitochondrial and subsequent apoptosis.	hydroxycamptothecinum	17-21	BCL2 apoptosis regulator	Homo sapiens	95-100
25573072-6	2015	Combinatorial TP/HCPT treatment significantly enhanced the activation of caspase-3 and -9, Bax/Bcl-2 ratio, release of cytochrome c from mitochondrial and subsequent apoptosis.	hydroxycamptothecinum	17-21	cytochrome c, somatic	Homo sapiens	119-131
25573072-10	2015	Finally, pharmacological inhibitors OA, SB203580, SP600125 and PD98059 confirm the role of PP2A and its substrates ERK, p38 MAPK and Akt in mediating TP/HCPT-induced apoptosis.	hydroxycamptothecinum	153-157	protein phosphatase 2 phosphatase activator	Homo sapiens	91-95
25573072-10	2015	Finally, pharmacological inhibitors OA, SB203580, SP600125 and PD98059 confirm the role of PP2A and its substrates ERK, p38 MAPK and Akt in mediating TP/HCPT-induced apoptosis.	hydroxycamptothecinum	153-157	mitogen-activated protein kinase 1	Homo sapiens	115-118
25573072-10	2015	Finally, pharmacological inhibitors OA, SB203580, SP600125 and PD98059 confirm the role of PP2A and its substrates ERK, p38 MAPK and Akt in mediating TP/HCPT-induced apoptosis.	hydroxycamptothecinum	153-157	mitogen-activated protein kinase 14	Homo sapiens	120-123
25573072-10	2015	Finally, pharmacological inhibitors OA, SB203580, SP600125 and PD98059 confirm the role of PP2A and its substrates ERK, p38 MAPK and Akt in mediating TP/HCPT-induced apoptosis.	hydroxycamptothecinum	153-157	mitogen-activated protein kinase 1	Homo sapiens	124-128
25573072-10	2015	Finally, pharmacological inhibitors OA, SB203580, SP600125 and PD98059 confirm the role of PP2A and its substrates ERK, p38 MAPK and Akt in mediating TP/HCPT-induced apoptosis.	hydroxycamptothecinum	153-157	AKT serine/threonine kinase 1	Homo sapiens	133-136
26045770-10	2015	HCPT treatment induced the upregulation of CHOP and downregulation of XIAP in HTCFs.	hydroxycamptothecinum	0-4	X-linked inhibitor of apoptosis	Homo sapiens	70-74
26045770-11	2015	To conclude, our results support HCPT induced the apoptosis of HTCFs, involving the activation of mitochondrial and endoplasmic reticulum stresses as well as the downregulation expression of XIAP.	hydroxycamptothecinum	33-37	X-linked inhibitor of apoptosis	Homo sapiens	191-195
24326092-5	2013	Gastric cancer cells with Pgp expression were resistant to ADM and HCPT (p = 0.008 and p = 0.011, respectively).	hydroxycamptothecinum	67-71	ATP binding cassette subfamily B member 1	Homo sapiens	26-29
24681041-0	2014	MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon"s capsule fibroblasts upon hydroxycamptothecin exposure.	hydroxycamptothecinum	104-123	microRNA 216b	Homo sapiens	0-13
24681041-0	2014	MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon"s capsule fibroblasts upon hydroxycamptothecin exposure.	hydroxycamptothecinum	104-123	beclin 1	Homo sapiens	14-22
24681041-4	2014	We showed that HCPT induced significant autophagy as well as apoptosis, two self-destructive processes, and down-regulated the expression of miR-216b in HTFs.	hydroxycamptothecinum	15-19	microRNA 216b	Homo sapiens	141-149
24681041-5	2014	Overexpression of miR-216b in HTFs suppressed the autophagy and apoptosis induced by HCPT, whereas silence of miR-216b led to effects that were similar to those caused by the treatment with HCPT.	hydroxycamptothecinum	85-89	microRNA 216b	Homo sapiens	18-26
24681041-7	2014	Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, thus implicating that Beclin 1 functions as a pro-apoptotic molecule in this circumstance.	hydroxycamptothecinum	61-65	beclin 1	Homo sapiens	28-36
24681041-7	2014	Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, thus implicating that Beclin 1 functions as a pro-apoptotic molecule in this circumstance.	hydroxycamptothecinum	61-65	beclin 1	Homo sapiens	178-186
24681041-7	2014	Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, thus implicating that Beclin 1 functions as a pro-apoptotic molecule in this circumstance.	hydroxycamptothecinum	150-154	beclin 1	Homo sapiens	28-36
24681041-7	2014	Consistently, knocking down Beclin 1 significantly decreased HCPT-triggered autophagy and apoptosis, and increased the viability of HTFs treated with HCPT, thus implicating that Beclin 1 functions as a pro-apoptotic molecule in this circumstance.	hydroxycamptothecinum	150-154	beclin 1	Homo sapiens	178-186
24681041-8	2014	Altogether, we concluded that miR-216b regulated both autophagy and apoptosis by modulating Beclin 1 in HTFs treated with HCPT.	hydroxycamptothecinum	122-126	microRNA 216b	Homo sapiens	30-38
24681041-8	2014	Altogether, we concluded that miR-216b regulated both autophagy and apoptosis by modulating Beclin 1 in HTFs treated with HCPT.	hydroxycamptothecinum	122-126	beclin 1	Homo sapiens	92-100
23761079-0	2013	Hydroxycamptothecin induces apoptosis of human tenon"s capsule fibroblasts by activating the PERK signaling pathway.	hydroxycamptothecinum	0-19	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	93-97
23708668-4	2013	In the present study, we showed that the levels of BLH were significantly reduced during apoptosis induced by the antitumor agents bleomycin, etoposide and hydroxycamptothecin, and inhibited by the caspase inhibitors Q-VD-oph and Z-DEVD-FMK.	hydroxycamptothecinum	156-175	bleomycin hydrolase	Homo sapiens	51-54
23761079-7	2013	RESULTS: HCPT induced apoptosis in the HTCFs, which was characterized as decreased cell viability and sub-S fraction of the cell cycle and increased apoptosis rate by Annexin V/PI dual-staining.	hydroxycamptothecinum	9-13	annexin A5	Homo sapiens	167-176
23761079-8	2013	The activity levels of caspase-3 and caspase-9 were significantly increased and were accompanied by cytosolic release of cyt c and decreased DeltaPsim in response to HCPT.	hydroxycamptothecinum	166-170	caspase 3	Homo sapiens	23-32
23761079-8	2013	The activity levels of caspase-3 and caspase-9 were significantly increased and were accompanied by cytosolic release of cyt c and decreased DeltaPsim in response to HCPT.	hydroxycamptothecinum	166-170	caspase 9	Homo sapiens	37-46
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	heat shock protein family A (Hsp70) member 5	Homo sapiens	48-76
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	heat shock protein family A (Hsp70) member 5	Homo sapiens	78-83
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	94-98
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	activating transcription factor 6	Homo sapiens	100-133
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	activating transcription factor 6	Homo sapiens	135-139
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	178-182
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	DNA damage inducible transcript 3	Homo sapiens	185-209
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	DNA damage inducible transcript 3	Homo sapiens	211-215
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	BCL2 associated X, apoptosis regulator	Homo sapiens	218-221
23761079-9	2013	Treatment with HCPT increased the expression of glucose-regulated protein 78 (GRP78), phospho-PERK, activating transcription factor 6 (ATF6), phosphoinositol-requiring kinase 1 (IRE1), C/EBP homologous protein (CHOP), Bax, and phospho-c-Jun N-terminal kinase (JNK) and decreased the expression of Bcl-2.	hydroxycamptothecinum	15-19	BCL2 apoptosis regulator	Homo sapiens	297-302
23761079-10	2013	Knockdown of PERK attenuates HCPT-induced apoptosis in HTCFs, dependent upon both ER stress and the mitochondrial apoptotic pathway.	hydroxycamptothecinum	29-33	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	13-17
23761079-11	2013	CONCLUSIONS: This study suggests that the ER stress response and mitochondrial dysfunction are involved in apoptosis induced by HCPT in HTCFs, which might be mediated by PERK; thus, this study offers new insight into preventing postoperative scarring via treatment with HCPT.	hydroxycamptothecinum	128-132	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	170-174
23721525-0	2013	Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression.	hydroxycamptothecinum	0-19	X-linked inhibitor of apoptosis	Homo sapiens	118-122
22985579-0	2012	[Hydroxycamptothecin inhibits proliferation of human lung carcinoma cell line A549 and down-regulates its Bcl-2 gene expression in vitro].	hydroxycamptothecinum	1-20	BCL2 apoptosis regulator	Homo sapiens	106-111
23365634-0	2013	Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-kappaB/IKK pathway-induced apoptosis.	hydroxycamptothecinum	45-49	ATM serine/threonine kinase	Homo sapiens	85-88
23365634-0	2013	Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-kappaB/IKK pathway-induced apoptosis.	hydroxycamptothecinum	45-49	nuclear factor kappa B subunit 1	Homo sapiens	89-98
23365634-7	2013	Pretreatment with genistein sensitized BDEC and bladder cancer cell lines to HCPT-induced DNA damage by the synergistic activation of ataxia telangiectasia mutated (ATM) kinase.	hydroxycamptothecinum	77-81	ATM serine/threonine kinase	Homo sapiens	165-168
23365634-8	2013	Genistein significantly attenuated the ability of HCPT to induce activation of the anti-apoptotic NF-kappaB pathway both in vitro and in vivo in a bladder cancer xenograft model, and thus counteracted the anti-apoptotic effect of the NF-kappaB pathway.	hydroxycamptothecinum	50-54	nuclear factor kappa B subunit 1	Homo sapiens	98-107
23365634-8	2013	Genistein significantly attenuated the ability of HCPT to induce activation of the anti-apoptotic NF-kappaB pathway both in vitro and in vivo in a bladder cancer xenograft model, and thus counteracted the anti-apoptotic effect of the NF-kappaB pathway.	hydroxycamptothecinum	50-54	nuclear factor kappa B subunit 1	Homo sapiens	234-243
22985579-9	2012	CONCLUSION: HCPT can significantly inhibit the proliferation, induce apoptosis, and down-regulate Bcl-2 gene expression in human lung carcinoma cell line A549, suggesting the involvement of Bcl-2 gene in the inhibitory effect of HCPT on A549 cells.	hydroxycamptothecinum	12-16	BCL2 apoptosis regulator	Homo sapiens	98-103
22985579-9	2012	CONCLUSION: HCPT can significantly inhibit the proliferation, induce apoptosis, and down-regulate Bcl-2 gene expression in human lung carcinoma cell line A549, suggesting the involvement of Bcl-2 gene in the inhibitory effect of HCPT on A549 cells.	hydroxycamptothecinum	12-16	BCL2 apoptosis regulator	Homo sapiens	190-195
22661476-10	2012	CONCLUSIONS: Caspase-3 and caspase-9 are important elements in regulating HCPT-induced apoptosis in HTFs.	hydroxycamptothecinum	74-78	caspase 3	Homo sapiens	13-22
22661476-10	2012	CONCLUSIONS: Caspase-3 and caspase-9 are important elements in regulating HCPT-induced apoptosis in HTFs.	hydroxycamptothecinum	74-78	caspase 9	Homo sapiens	27-36
22460090-0	2012	Increased expression of DNA repair gene XPF enhances resistance to hydroxycamptothecin in bladder cancer.	hydroxycamptothecinum	67-86	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	40-43
23044204-1	2012	To investigate the molecular mechanism of hydroxycamptothecin (HCPT)-mediated anti-hepatic fibrosis by evaluting its effects on expression of tumor growth factor-beta 1 (TGFb1), alpha-smooth muscle actin (a-SMA) and collagen I (Col I) in hepatic satellite cells (HSCs).	hydroxycamptothecinum	42-61	transforming growth factor, beta 1	Rattus norvegicus	142-168
23044204-1	2012	To investigate the molecular mechanism of hydroxycamptothecin (HCPT)-mediated anti-hepatic fibrosis by evaluting its effects on expression of tumor growth factor-beta 1 (TGFb1), alpha-smooth muscle actin (a-SMA) and collagen I (Col I) in hepatic satellite cells (HSCs).	hydroxycamptothecinum	42-61	transforming growth factor, beta 1	Rattus norvegicus	170-175
23044204-1	2012	To investigate the molecular mechanism of hydroxycamptothecin (HCPT)-mediated anti-hepatic fibrosis by evaluting its effects on expression of tumor growth factor-beta 1 (TGFb1), alpha-smooth muscle actin (a-SMA) and collagen I (Col I) in hepatic satellite cells (HSCs).	hydroxycamptothecinum	42-61	actin gamma 2, smooth muscle	Rattus norvegicus	178-203
23044204-1	2012	To investigate the molecular mechanism of hydroxycamptothecin (HCPT)-mediated anti-hepatic fibrosis by evaluting its effects on expression of tumor growth factor-beta 1 (TGFb1), alpha-smooth muscle actin (a-SMA) and collagen I (Col I) in hepatic satellite cells (HSCs).	hydroxycamptothecinum	63-67	transforming growth factor, beta 1	Rattus norvegicus	142-168
23044204-1	2012	To investigate the molecular mechanism of hydroxycamptothecin (HCPT)-mediated anti-hepatic fibrosis by evaluting its effects on expression of tumor growth factor-beta 1 (TGFb1), alpha-smooth muscle actin (a-SMA) and collagen I (Col I) in hepatic satellite cells (HSCs).	hydroxycamptothecinum	63-67	actin gamma 2, smooth muscle	Rattus norvegicus	178-203
23044204-11	2012	The mechanism of HCPT-mediated anti-hepatic fibrosis may involve down-regulation of TGFb1 expression to inhibit HSC proliferation and activation, as well as reduction of Col I synthesis and secretion.	hydroxycamptothecinum	17-21	transforming growth factor, beta 1	Rattus norvegicus	84-89
22265915-7	2012	The histopathological staining and immunohistochemical examinations of caspase-3 expression indicated more necrosis and apoptosis induced by HCPT-loaded fibers.	hydroxycamptothecinum	141-145	caspase 3	Mus musculus	71-80
22460090-6	2012	RESULTS: The XPF expressions in the HCPT-treated cancer tissues was significantly higher than those in the untreated cancer tissues at both mRNA and protein levels.	hydroxycamptothecinum	36-40	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	13-16
22460090-7	2012	Importantly, the enhanced XPF expression decreased the sensitivity of T24 cells and 5637 cells to HCPT.	hydroxycamptothecinum	98-102	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	26-29
21401896-0	2011	RNA interference (RNAi) of Ufd1 protein can sensitize a hydroxycamptothecin-resistant colon cancer cell line SW1116/HCPT to hydroxycamptothecin.	hydroxycamptothecinum	56-75	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	27-31
22870247-5	2012	In the hydroxycamptothecin (HCPT) resistant cell line SW1116/HCPT from human colon cancer cell line SW1116, ABCG2 is the major factor for multidrug resistance, other than well-studied ABCB1 or ABCC1.	hydroxycamptothecinum	7-26	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	108-113
22870247-5	2012	In the hydroxycamptothecin (HCPT) resistant cell line SW1116/HCPT from human colon cancer cell line SW1116, ABCG2 is the major factor for multidrug resistance, other than well-studied ABCB1 or ABCC1.	hydroxycamptothecinum	7-26	ATP binding cassette subfamily C member 1	Homo sapiens	193-198
22870247-5	2012	In the hydroxycamptothecin (HCPT) resistant cell line SW1116/HCPT from human colon cancer cell line SW1116, ABCG2 is the major factor for multidrug resistance, other than well-studied ABCB1 or ABCC1.	hydroxycamptothecinum	28-32	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	108-113
22870247-5	2012	In the hydroxycamptothecin (HCPT) resistant cell line SW1116/HCPT from human colon cancer cell line SW1116, ABCG2 is the major factor for multidrug resistance, other than well-studied ABCB1 or ABCC1.	hydroxycamptothecinum	28-32	ATP binding cassette subfamily B member 1	Homo sapiens	184-189
22870247-5	2012	In the hydroxycamptothecin (HCPT) resistant cell line SW1116/HCPT from human colon cancer cell line SW1116, ABCG2 is the major factor for multidrug resistance, other than well-studied ABCB1 or ABCC1.	hydroxycamptothecinum	28-32	ATP binding cassette subfamily C member 1	Homo sapiens	193-198
22870247-10	2012	Definitely, inhibition of the JNK1/c-jun pathway is useful for reversing ABCG2-mediated drug resistance in HCPT-resistant colon cancer cells.	hydroxycamptothecinum	107-111	mitogen-activated protein kinase 8	Homo sapiens	30-34
22870247-10	2012	Definitely, inhibition of the JNK1/c-jun pathway is useful for reversing ABCG2-mediated drug resistance in HCPT-resistant colon cancer cells.	hydroxycamptothecinum	107-111	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	35-40
22870247-10	2012	Definitely, inhibition of the JNK1/c-jun pathway is useful for reversing ABCG2-mediated drug resistance in HCPT-resistant colon cancer cells.	hydroxycamptothecinum	107-111	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-78
22036718-0	2011	MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells.	hydroxycamptothecinum	51-70	peroxisome proliferator activated receptor alpha	Homo sapiens	37-47
21435100-0	2011	Hydroxycamptothecin-loaded Fe3O4 nanoparticles induce human lung cancer cell apoptosis through caspase-8 pathway activation and disrupt tight junctions.	hydroxycamptothecinum	0-19	caspase 8	Homo sapiens	95-104
22051412-1	2012	In this study, the binding interactions of the water-soluble camptothecin derivatives hydroxycamptothecin (10-HCPT), topotecan (TPT), and camptothecin quaternary salt (CPT8), to bovine serum albumin (BSA) were determined using fluorescence spectra and UV-vis spectra.	hydroxycamptothecinum	86-105	albumin	Homo sapiens	185-198
22010354-0	2011	[Pharmaceutical evaluation of hydroxycamptothecin nanosuspensions with the action of inhibiting P-gp].	hydroxycamptothecinum	30-49	phosphoglycolate phosphatase	Homo sapiens	96-100
21401896-0	2011	RNA interference (RNAi) of Ufd1 protein can sensitize a hydroxycamptothecin-resistant colon cancer cell line SW1116/HCPT to hydroxycamptothecin.	hydroxycamptothecinum	124-143	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	27-31
21401896-1	2011	OBJECTIVE: To investigate whether RNA interference (RNAi) of the ubiquitin fusion-degradation 1-like protein (Ufd1) could sensitize hydroxycamptothecin (HCPT)-resistant colon cancer cell line SW1116/HCPT to the cytotoxic effect of HCPT.	hydroxycamptothecinum	132-151	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	65-108
21401896-1	2011	OBJECTIVE: To investigate whether RNA interference (RNAi) of the ubiquitin fusion-degradation 1-like protein (Ufd1) could sensitize hydroxycamptothecin (HCPT)-resistant colon cancer cell line SW1116/HCPT to the cytotoxic effect of HCPT.	hydroxycamptothecinum	132-151	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	110-114
21401896-1	2011	OBJECTIVE: To investigate whether RNA interference (RNAi) of the ubiquitin fusion-degradation 1-like protein (Ufd1) could sensitize hydroxycamptothecin (HCPT)-resistant colon cancer cell line SW1116/HCPT to the cytotoxic effect of HCPT.	hydroxycamptothecinum	153-157	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	65-108
21401896-1	2011	OBJECTIVE: To investigate whether RNA interference (RNAi) of the ubiquitin fusion-degradation 1-like protein (Ufd1) could sensitize hydroxycamptothecin (HCPT)-resistant colon cancer cell line SW1116/HCPT to the cytotoxic effect of HCPT.	hydroxycamptothecinum	153-157	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	110-114
21401896-1	2011	OBJECTIVE: To investigate whether RNA interference (RNAi) of the ubiquitin fusion-degradation 1-like protein (Ufd1) could sensitize hydroxycamptothecin (HCPT)-resistant colon cancer cell line SW1116/HCPT to the cytotoxic effect of HCPT.	hydroxycamptothecinum	199-203	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	65-108
21401896-1	2011	OBJECTIVE: To investigate whether RNA interference (RNAi) of the ubiquitin fusion-degradation 1-like protein (Ufd1) could sensitize hydroxycamptothecin (HCPT)-resistant colon cancer cell line SW1116/HCPT to the cytotoxic effect of HCPT.	hydroxycamptothecinum	199-203	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	110-114
21401896-8	2011	The Western blot showed that increasing the concentration of HCPT resulted in a higher expression level of p-JNK, P53, ubiquitin, GADD 153 and Grp78/Bip in the Ufd1 knockdown cells than that in the control cells.	hydroxycamptothecinum	61-65	tumor protein p53	Homo sapiens	114-117
21401896-8	2011	The Western blot showed that increasing the concentration of HCPT resulted in a higher expression level of p-JNK, P53, ubiquitin, GADD 153 and Grp78/Bip in the Ufd1 knockdown cells than that in the control cells.	hydroxycamptothecinum	61-65	DNA damage inducible transcript 3	Homo sapiens	130-138
21401896-8	2011	The Western blot showed that increasing the concentration of HCPT resulted in a higher expression level of p-JNK, P53, ubiquitin, GADD 153 and Grp78/Bip in the Ufd1 knockdown cells than that in the control cells.	hydroxycamptothecinum	61-65	heat shock protein family A (Hsp70) member 5	Homo sapiens	143-148
21401896-8	2011	The Western blot showed that increasing the concentration of HCPT resulted in a higher expression level of p-JNK, P53, ubiquitin, GADD 153 and Grp78/Bip in the Ufd1 knockdown cells than that in the control cells.	hydroxycamptothecinum	61-65	heat shock protein family A (Hsp70) member 5	Homo sapiens	149-152
21401896-8	2011	The Western blot showed that increasing the concentration of HCPT resulted in a higher expression level of p-JNK, P53, ubiquitin, GADD 153 and Grp78/Bip in the Ufd1 knockdown cells than that in the control cells.	hydroxycamptothecinum	61-65	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	160-164
21401896-9	2011	CONCLUSION: Ufd1 plays a key role in HCPT resistance of SW1116/HCPT and RNAi of Ufd1 can sensitize SW1116/HCPT to the cytotoxic effect of HCPT via strengthening the activation of caspase-3 pathway and disturbing endoplasmic reticulum functions.	hydroxycamptothecinum	37-41	ubiquitin recognition factor in ER associated degradation 1	Homo sapiens	12-16
21401896-9	2011	CONCLUSION: Ufd1 plays a key role in HCPT resistance of SW1116/HCPT and RNAi of Ufd1 can sensitize SW1116/HCPT to the cytotoxic effect of HCPT via strengthening the activation of caspase-3 pathway and disturbing endoplasmic reticulum functions.	hydroxycamptothecinum	37-41	caspase 3	Homo sapiens	179-188
20501387-8	2010	CONCLUSION: The combined use of cyclopamine and hydroxycamptothecin significantly down-regulates the expression on of bcl-2 to induce the apoptosis of human OSCC cell line HSQ-89.	hydroxycamptothecinum	48-67	BCL2 apoptosis regulator	Homo sapiens	118-123
21293479-2	2011	METHODS: A sulforhodamine B (SRB) assay was used to analyze the sensitivity to HCPT of six gastric cancer cell lines.	hydroxycamptothecinum	79-83	chaperonin containing TCP1 subunit 4	Homo sapiens	11-27
21293479-2	2011	METHODS: A sulforhodamine B (SRB) assay was used to analyze the sensitivity to HCPT of six gastric cancer cell lines.	hydroxycamptothecinum	79-83	chaperonin containing TCP1 subunit 4	Homo sapiens	29-32
21213403-4	2011	Our results showed that the sensitivity of a combined therapy using triptolide and HCPT was higher than that of triptolide or HCPT alone and that activation of caspase-9/caspase-3 and inhibition of nuclear factor-kappaB (NF-kappaB) signaling pathway may contribute to the synergistic cytotoxic effect of this combination therapy.	hydroxycamptothecinum	83-87	caspase 9	Homo sapiens	160-169
21213403-4	2011	Our results showed that the sensitivity of a combined therapy using triptolide and HCPT was higher than that of triptolide or HCPT alone and that activation of caspase-9/caspase-3 and inhibition of nuclear factor-kappaB (NF-kappaB) signaling pathway may contribute to the synergistic cytotoxic effect of this combination therapy.	hydroxycamptothecinum	126-130	caspase 9	Homo sapiens	160-169
19897602-9	2010	Furthermore, Hep-12 cells expressed higher levels of poly (adenosine diphosphate-ribose) polymerase-1 (PARP-1) than Hep-11, and PARP-1 inhibition potentiated the sensitivity to HCPT in Hep-12 cells but not in Hep-11 cells.	hydroxycamptothecinum	177-181	poly(ADP-ribose) polymerase 1	Homo sapiens	103-109
19897602-9	2010	Furthermore, Hep-12 cells expressed higher levels of poly (adenosine diphosphate-ribose) polymerase-1 (PARP-1) than Hep-11, and PARP-1 inhibition potentiated the sensitivity to HCPT in Hep-12 cells but not in Hep-11 cells.	hydroxycamptothecinum	177-181	poly(ADP-ribose) polymerase 1	Homo sapiens	128-134
19897602-10	2010	These results indicate that a large population of the recurrent HCC-derived Hep-12 cells were tumor-initiating cells and that elevated expression of PARP-1 was related to their resistance to HCPT.	hydroxycamptothecinum	191-195	poly(ADP-ribose) polymerase 1	Homo sapiens	149-155
18840485-0	2009	Efficient tumor targeting of hydroxycamptothecin loaded PEGylated niosomes modified with transferrin.	hydroxycamptothecinum	29-48	transferrin	Mus musculus	89-100
18840485-2	2009	HCPT-loaded PEG-niosomes (PEG-NS) were prepared by thin-film hydration and ultrasound method; the periodate-oxidated Tf was coupled to terminal amino group of PEG to produce the active targeting vesicles with average diameters of 116 nm.	hydroxycamptothecinum	0-4	transferrin	Mus musculus	117-119
18801171-1	2008	BACKGROUND: Previous studies demonstrated the EGF-targeted phagemid particles carrying siRNA against Akt could be expressed efficiently in the presence of hydroxycamptothecin (HCPT).	hydroxycamptothecinum	155-174	AKT serine/threonine kinase 1	Homo sapiens	101-104
18801171-1	2008	BACKGROUND: Previous studies demonstrated the EGF-targeted phagemid particles carrying siRNA against Akt could be expressed efficiently in the presence of hydroxycamptothecin (HCPT).	hydroxycamptothecinum	176-180	AKT serine/threonine kinase 1	Homo sapiens	101-104
18358089-11	2008	After the cells were infected by EGF displaying phagemid particles in the presence of HCPT, the expression of the target gene EGFP or Akt was substantially downregulated.	hydroxycamptothecinum	86-90	AKT serine/threonine kinase 1	Homo sapiens	134-137
17977319-0	2007	[Hydroxycamptothecin promotes the apoptosis of prostate cancer cell line PC-3].	hydroxycamptothecinum	1-20	chromobox 8	Homo sapiens	73-77
17977319-1	2007	OBJECTIVE: To observe the effects of hydroxycamptothecin (HCPT) on the apoptosis of prostate cancer cell line PC-3 and to explore the possible mechanism.	hydroxycamptothecinum	37-56	chromobox 8	Homo sapiens	110-114
17977319-1	2007	OBJECTIVE: To observe the effects of hydroxycamptothecin (HCPT) on the apoptosis of prostate cancer cell line PC-3 and to explore the possible mechanism.	hydroxycamptothecinum	58-62	chromobox 8	Homo sapiens	110-114
17977319-6	2007	RESULTS: The growth of PC-3 was inhibited by HCPT in a time- and dose- dependent manner.	hydroxycamptothecinum	45-49	chromobox 8	Homo sapiens	23-27
17977319-10	2007	FCM analysis showed that the apoptosis rate of PC-3 cells increased with the increasing dose of HCPT, which reached the peak (35.76%) at 1 x 10(-3) mg/ml.	hydroxycamptothecinum	96-100	chromobox 8	Homo sapiens	47-51
17977319-11	2007	CONCLUSION: HCPT could suppress PC-3 cell proliferation significantly by inducing the apoptosis of PC-3 cells.	hydroxycamptothecinum	12-16	chromobox 8	Homo sapiens	32-36
17977319-11	2007	CONCLUSION: HCPT could suppress PC-3 cell proliferation significantly by inducing the apoptosis of PC-3 cells.	hydroxycamptothecinum	12-16	chromobox 8	Homo sapiens	99-103