PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 26787261-4 2016 Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells. arjunic acid 14-26 poly(ADP-ribose) polymerase 1 Homo sapiens 35-63 31767507-0 2020 In-silico therapeutic investigations of arjunic acid and arjungenin as an FXR agonist and validation in 3T3-L1 adipocytes. arjunic acid 40-52 nuclear receptor subfamily 1 group H member 4 Homo sapiens 74-77 31767507-1 2020 The present study was to illustrate the agonistic property of arjungenin and arjunic acid towards farnesoid X receptor protein (FXR).The pharmacokinetic properties like molecular interactions, absorption, distribution, metabolism, elimination and toxicity (ADMET) of the ligands were checked through in-silico studies. arjunic acid 77-89 nuclear receptor subfamily 1 group H member 4 Homo sapiens 98-126 31767507-1 2020 The present study was to illustrate the agonistic property of arjungenin and arjunic acid towards farnesoid X receptor protein (FXR).The pharmacokinetic properties like molecular interactions, absorption, distribution, metabolism, elimination and toxicity (ADMET) of the ligands were checked through in-silico studies. arjunic acid 77-89 nuclear receptor subfamily 1 group H member 4 Homo sapiens 128-131 31767507-8 2020 Treatment with arjungenin and arjunic acid confirms increased differentiation of the cells with significant (P < 0.05) increase in adiponectin (118.07% and 132.92%) and leptin (133.52% and 149.74%) protein levels compared to the negative control group. arjunic acid 30-42 adiponectin, C1Q and collagen domain containing Homo sapiens 131-142 31767507-8 2020 Treatment with arjungenin and arjunic acid confirms increased differentiation of the cells with significant (P < 0.05) increase in adiponectin (118.07% and 132.92%) and leptin (133.52% and 149.74%) protein levels compared to the negative control group. arjunic acid 30-42 leptin Homo sapiens 169-175 31767507-9 2020 After treatment with arjungenin and arjunic acid in 3T3-L1 preadipocytes the mRNA expression of FXR, PPAR-gamma and SREBP-1c were significantly (P < 0.01) increased and cyp7a1 was significantly (P < 0.01) decreased when compared with the negative control group. arjunic acid 36-48 nuclear receptor subfamily 1 group H member 4 Homo sapiens 96-99 31767507-9 2020 After treatment with arjungenin and arjunic acid in 3T3-L1 preadipocytes the mRNA expression of FXR, PPAR-gamma and SREBP-1c were significantly (P < 0.01) increased and cyp7a1 was significantly (P < 0.01) decreased when compared with the negative control group. arjunic acid 36-48 peroxisome proliferator activated receptor gamma Homo sapiens 101-111 31767507-9 2020 After treatment with arjungenin and arjunic acid in 3T3-L1 preadipocytes the mRNA expression of FXR, PPAR-gamma and SREBP-1c were significantly (P < 0.01) increased and cyp7a1 was significantly (P < 0.01) decreased when compared with the negative control group. arjunic acid 36-48 sterol regulatory element binding transcription factor 1 Homo sapiens 116-124 31767507-9 2020 After treatment with arjungenin and arjunic acid in 3T3-L1 preadipocytes the mRNA expression of FXR, PPAR-gamma and SREBP-1c were significantly (P < 0.01) increased and cyp7a1 was significantly (P < 0.01) decreased when compared with the negative control group. arjunic acid 36-48 cytochrome P450 family 7 subfamily A member 1 Homo sapiens 169-175 31767507-10 2020 Overall, our results suggest that arjungenin and arjunic acid acts as an FXR agonist and may be useful for rational therapeutic strategies as a novel drug to treat cholesterol mediated metabolic syndrome and insulin resistance. arjunic acid 49-61 nuclear receptor subfamily 1 group H member 4 Homo sapiens 73-76 26787261-4 2016 Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells. arjunic acid 14-26 poly(ADP-ribose) polymerase 1 Homo sapiens 65-69 26787261-4 2016 Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells. arjunic acid 14-26 BCL2 associated X, apoptosis regulator Homo sapiens 82-85 26787261-4 2016 Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells. arjunic acid 14-26 mitogen-activated protein kinase 8 Homo sapiens 110-134 26787261-4 2016 Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells. arjunic acid 14-26 mitogen-activated protein kinase 8 Homo sapiens 136-139 26787261-4 2016 Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells. arjunic acid 14-26 caspase 3 Homo sapiens 180-193 26787261-4 2016 Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells. arjunic acid 14-26 BCL2 apoptosis regulator Homo sapiens 198-203 26787261-5 2016 Furthermore, arjunic acid upregulated the expression of endoplasmic reticulum (ER) stress proteins such as IRE1 alpha, ATF4, p-eIF2alpha, and C/EBP homologous protein (CHOP) in A549 and H460 cells. arjunic acid 13-25 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 107-117 26787261-5 2016 Furthermore, arjunic acid upregulated the expression of endoplasmic reticulum (ER) stress proteins such as IRE1 alpha, ATF4, p-eIF2alpha, and C/EBP homologous protein (CHOP) in A549 and H460 cells. arjunic acid 13-25 activating transcription factor 4 Homo sapiens 119-123 26787261-5 2016 Furthermore, arjunic acid upregulated the expression of endoplasmic reticulum (ER) stress proteins such as IRE1 alpha, ATF4, p-eIF2alpha, and C/EBP homologous protein (CHOP) in A549 and H460 cells. arjunic acid 13-25 DNA damage inducible transcript 3 Homo sapiens 142-166 26787261-5 2016 Furthermore, arjunic acid upregulated the expression of endoplasmic reticulum (ER) stress proteins such as IRE1 alpha, ATF4, p-eIF2alpha, and C/EBP homologous protein (CHOP) in A549 and H460 cells. arjunic acid 13-25 DNA damage inducible transcript 3 Homo sapiens 168-172 26787261-6 2016 Conversely, CHOP depletion attenuated the increase of sub-G1 population by arjunic acid, and also JNK inhibitor SP600125 blocked the cytotoxicity and upregulation of IRE1 alpha and CHOP induced by arjunic acid in A549 and H460 cells. arjunic acid 75-87 DNA damage inducible transcript 3 Homo sapiens 12-16 26787261-6 2016 Conversely, CHOP depletion attenuated the increase of sub-G1 population by arjunic acid, and also JNK inhibitor SP600125 blocked the cytotoxicity and upregulation of IRE1 alpha and CHOP induced by arjunic acid in A549 and H460 cells. arjunic acid 75-87 DNA damage inducible transcript 3 Homo sapiens 181-185 26787261-6 2016 Conversely, CHOP depletion attenuated the increase of sub-G1 population by arjunic acid, and also JNK inhibitor SP600125 blocked the cytotoxicity and upregulation of IRE1 alpha and CHOP induced by arjunic acid in A549 and H460 cells. arjunic acid 197-209 DNA damage inducible transcript 3 Homo sapiens 12-16 26787261-6 2016 Conversely, CHOP depletion attenuated the increase of sub-G1 population by arjunic acid, and also JNK inhibitor SP600125 blocked the cytotoxicity and upregulation of IRE1 alpha and CHOP induced by arjunic acid in A549 and H460 cells. arjunic acid 197-209 mitogen-activated protein kinase 8 Homo sapiens 98-101 26787261-6 2016 Conversely, CHOP depletion attenuated the increase of sub-G1 population by arjunic acid, and also JNK inhibitor SP600125 blocked the cytotoxicity and upregulation of IRE1 alpha and CHOP induced by arjunic acid in A549 and H460 cells. arjunic acid 197-209 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 166-176 26787261-6 2016 Conversely, CHOP depletion attenuated the increase of sub-G1 population by arjunic acid, and also JNK inhibitor SP600125 blocked the cytotoxicity and upregulation of IRE1 alpha and CHOP induced by arjunic acid in A549 and H460 cells. arjunic acid 197-209 DNA damage inducible transcript 3 Homo sapiens 181-185 26787261-7 2016 Overall, our findings suggest that arjunic acid induces apoptosis in NSCLC cells via JNK mediated ER stress pathway as a potent chemotherapeutic agent for NSCLC. arjunic acid 35-47 mitogen-activated protein kinase 8 Homo sapiens 85-88 28962416-0 2015 In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin and arjungenin on CYP3A4, CYP2D6 and CYP2C9 enzyme activity in human liver microsomes. arjunic acid 50-62 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 100-106 28962416-0 2015 In vitro modulatory effects of Terminalia arjuna, arjunic acid, arjunetin and arjungenin on CYP3A4, CYP2D6 and CYP2C9 enzyme activity in human liver microsomes. arjunic acid 50-62 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 111-117 28962416-3 2015 Alcoholic and aqueous bark extracts of T. arjuna, arjunic acid, arjunetin and arjungenin were evaluated for their potential to inhibit CYP3A4, CYP2D6 and CYP2C9 enzymes in human liver microsomes. arjunic acid 50-62 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 143-149 28962416-3 2015 Alcoholic and aqueous bark extracts of T. arjuna, arjunic acid, arjunetin and arjungenin were evaluated for their potential to inhibit CYP3A4, CYP2D6 and CYP2C9 enzymes in human liver microsomes. arjunic acid 50-62 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 154-160 18008199-3 2007 Out of the four compounds, arjunic acid (1) was significantly active against the human oral (KB), ovarian (PA 1) and liver (HepG-2 & WRL-68) cancer cell lines. arjunic acid 27-39 PAXIP1 associated glutamate rich protein 1 Homo sapiens 107-111