PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 35597409-19 2022 RESULTS: Berberine, jateorhizine, coptisine, epiberberine, columbamine, demethyleneberberine, and berberrubine could significantly inhibit hOCT1 and hOCT2 activity. jatrorrhizine 20-32 solute carrier family 22 member 1 Homo sapiens 139-144 34211397-4 2021 Methods: Degradation of berberine/jatrorrhizine/coptisine/palmatine from CREA/CREB/CREC in rat/mouse intestinal contents and their impact on nine common gastrointestinal bacteria were investigated. jatrorrhizine 34-47 cAMP responsive element binding protein 1 Rattus norvegicus 78-82 35597409-20 2022 Isoquinoline alkaloids, including berberine, jateorhizine, coptisine, epiberberine, columbamine, and palmatine, were substrates of hOCT1 and hOCT2, but not the indole alkaloids evodiamine and rutaecarpine. jatrorrhizine 45-57 solute carrier family 22 member 1 Homo sapiens 131-136 34150044-0 2021 Jatrorrhizine can improve nerve cell injury induced by Abeta 25-35, acting through miR-223-3p/HDAC4 axis. jatrorrhizine 0-13 microRNA 223 Homo sapiens 83-90 34150044-0 2021 Jatrorrhizine can improve nerve cell injury induced by Abeta 25-35, acting through miR-223-3p/HDAC4 axis. jatrorrhizine 0-13 histone deacetylase 4 Homo sapiens 94-99 34150044-1 2021 OBJECTIVE: The purpose of this research is to probe the mechanism of Jatrorrhizine (JAT) improving Abeta 25-35-induced nerve cell injury through the miR-223-3p/HDAC4 axis. jatrorrhizine 69-82 microRNA 223 Homo sapiens 149-156 34150044-1 2021 OBJECTIVE: The purpose of this research is to probe the mechanism of Jatrorrhizine (JAT) improving Abeta 25-35-induced nerve cell injury through the miR-223-3p/HDAC4 axis. jatrorrhizine 69-82 histone deacetylase 4 Homo sapiens 160-165 34150044-1 2021 OBJECTIVE: The purpose of this research is to probe the mechanism of Jatrorrhizine (JAT) improving Abeta 25-35-induced nerve cell injury through the miR-223-3p/HDAC4 axis. jatrorrhizine 84-87 microRNA 223 Homo sapiens 149-156 34150044-1 2021 OBJECTIVE: The purpose of this research is to probe the mechanism of Jatrorrhizine (JAT) improving Abeta 25-35-induced nerve cell injury through the miR-223-3p/HDAC4 axis. jatrorrhizine 84-87 histone deacetylase 4 Homo sapiens 160-165 35597409-19 2022 RESULTS: Berberine, jateorhizine, coptisine, epiberberine, columbamine, demethyleneberberine, and berberrubine could significantly inhibit hOCT1 and hOCT2 activity. jatrorrhizine 20-32 POU class 2 homeobox 2 Homo sapiens 149-154 31302315-0 2019 Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/beta-catenin signalling and epithelial-mesenchymal transition (EMT). jatrorrhizine 0-13 TRAF2 and NCK interacting kinase Homo sapiens 60-64 33506010-10 2021 Moreover, the TNF-alpha decreased significantly accompanied by the increase of berberine, chlorogenic acid, jatrorrhizine, palmatine, evodin, and evodiamine in serum (negative correlation, p < 0.05). jatrorrhizine 108-121 tumor necrosis factor Rattus norvegicus 14-23 31368836-3 2020 Uptake of jatrorrhizine in OATP1B3 and OCT1-HEK293 cells indicated a saturable process with the Km of 8.20 +- 1.28 and 4.94 +- 0.55 muM, respectively. jatrorrhizine 10-23 solute carrier family 22 (organic cation transporter), member 1 Mus musculus 39-43 31368836-5 2020 Rifampicin (OATP inhibitor) for OATP1B3-HEK293 cells and prazosin for OCT1-HEK293 cells could inhibit the uptake of jatrorrhizine with the IC50 of 5.49 +- 1.05 and 2.77 +- 0.72 muM, respectively.The above data indicate that hepatic uptake of jatrorrhizine is involved in both OATP and OCT, which may have important roles in jatrorrhizine liver disposition and potential drug-drug interactions. jatrorrhizine 116-129 solute carrier organic anion transporter family member 1A2 Homo sapiens 12-16 31368836-5 2020 Rifampicin (OATP inhibitor) for OATP1B3-HEK293 cells and prazosin for OCT1-HEK293 cells could inhibit the uptake of jatrorrhizine with the IC50 of 5.49 +- 1.05 and 2.77 +- 0.72 muM, respectively.The above data indicate that hepatic uptake of jatrorrhizine is involved in both OATP and OCT, which may have important roles in jatrorrhizine liver disposition and potential drug-drug interactions. jatrorrhizine 116-129 solute carrier family 22 (organic cation transporter), member 1 Mus musculus 70-74 32341329-0 2020 Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum(II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) Pathway. jatrorrhizine 48-61 AKT serine/threonine kinase 1 Homo sapiens 110-113 32341329-0 2020 Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum(II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) Pathway. jatrorrhizine 48-61 mechanistic target of rapamycin kinase Homo sapiens 114-143 32341329-0 2020 Apoptosis Activation in Thyroid Cancer Cells by Jatrorrhizine-Platinum(II) Complex via Downregulation of PI3K/AKT/Mammalian Target of Rapamycin (mTOR) Pathway. jatrorrhizine 48-61 mechanistic target of rapamycin kinase Homo sapiens 145-149 31862965-0 2019 Jatrorrhizine Balances the Gut Microbiota and Reverses Learning and Memory Deficits in APP/PS1 transgenic mice. jatrorrhizine 0-13 presenilin 1 Mus musculus 91-94 31862965-5 2019 Furthermore, we also found that JAT treatment reduced the levels of Abeta plaques in the cortex and hippocampus of APP/PS1 double-transgenic mice. jatrorrhizine 32-35 presenilin 1 Mus musculus 119-122 31862965-9 2019 Furthermore, JAT treatment enriched OTUs abundance and alpha diversity in APP/PS1 mice compared to WT mice. jatrorrhizine 13-16 presenilin 1 Mus musculus 78-81 31862965-10 2019 High dose of JAT treatment altered the abundance of some specific gut microbiota such as the most predominant phylum Firmicutes and Bacteroidetes in APP/PS1 mice. jatrorrhizine 13-16 amyloid beta (A4) precursor protein Mus musculus 149-156 31302315-0 2019 Jatrorrhizine inhibits mammary carcinoma cells by targeting TNIK mediated Wnt/beta-catenin signalling and epithelial-mesenchymal transition (EMT). jatrorrhizine 0-13 catenin beta 1 Homo sapiens 78-90 31302315-2 2019 Molecular docking revealed that jatrorrhizine, a protoberberine alkaloid, exhibits good binding affinity and interaction with TNIK. jatrorrhizine 32-45 TRAF2 and NCK interacting kinase Homo sapiens 126-130 31302315-3 2019 However, the underlying mechanisms of jatrorrhizine targeting TNIK inhibits the proliferation and metastasis of breast cancer cells remain unclear. jatrorrhizine 38-51 TRAF2 and NCK interacting kinase Homo sapiens 62-66 31302315-7 2019 RESULTS: The results showed that targeted knockout of TNIK that attenuated Wnt/beta-catenin signalling and epithelial-mesenchymal transition (EMT) expression, the effects were potentiated by the addition of jatrorrhizine. jatrorrhizine 207-220 TRAF2 and NCK interacting kinase Homo sapiens 54-58 31302315-7 2019 RESULTS: The results showed that targeted knockout of TNIK that attenuated Wnt/beta-catenin signalling and epithelial-mesenchymal transition (EMT) expression, the effects were potentiated by the addition of jatrorrhizine. jatrorrhizine 207-220 catenin beta 1 Homo sapiens 79-91 31302315-10 2019 CONCLUSION: These findings provide an overall perspective that jatrorrhizine potentially restrains TNIK regulating Wnt/beta-catenin signalling and EMT expression for mammary cancer targeted therapy. jatrorrhizine 63-76 TRAF2 and NCK interacting kinase Homo sapiens 99-103 31302315-10 2019 CONCLUSION: These findings provide an overall perspective that jatrorrhizine potentially restrains TNIK regulating Wnt/beta-catenin signalling and EMT expression for mammary cancer targeted therapy. jatrorrhizine 63-76 catenin beta 1 Homo sapiens 119-131 30472912-5 2019 In vitro uptake tests showed that jatrorrhizine strongly inhibited PMAT-mediated MPP+ uptake with an IC50 value of 1.05 muM and reduced 5-HT and NE uptake mediated by hOCT2, hOCT3 and hPMAT with IC50 values of 0.1-1 muM (for OCT2 and OCT3) and 1-10 muM (for PMAT). jatrorrhizine 34-47 POU domain, class 5, transcription factor 1 Mus musculus 175-179 30472912-3 2019 Based on our previous finding that jatrorrhizine was a potent inhibitor of OCT2 and OCT3, the aim of the present study was to explore whether jatrorrhizine has an antidepressant-like action action via inhibition of uptake-2 transporters. jatrorrhizine 35-48 POU domain, class 2, transcription factor 2 Mus musculus 75-79 30472912-3 2019 Based on our previous finding that jatrorrhizine was a potent inhibitor of OCT2 and OCT3, the aim of the present study was to explore whether jatrorrhizine has an antidepressant-like action action via inhibition of uptake-2 transporters. jatrorrhizine 35-48 POU domain, class 5, transcription factor 1 Mus musculus 84-88 30472912-3 2019 Based on our previous finding that jatrorrhizine was a potent inhibitor of OCT2 and OCT3, the aim of the present study was to explore whether jatrorrhizine has an antidepressant-like action action via inhibition of uptake-2 transporters. jatrorrhizine 142-155 POU domain, class 2, transcription factor 2 Mus musculus 75-79 30472912-5 2019 In vitro uptake tests showed that jatrorrhizine strongly inhibited PMAT-mediated MPP+ uptake with an IC50 value of 1.05 muM and reduced 5-HT and NE uptake mediated by hOCT2, hOCT3 and hPMAT with IC50 values of 0.1-1 muM (for OCT2 and OCT3) and 1-10 muM (for PMAT). jatrorrhizine 34-47 solute carrier family 29 (nucleoside transporters), member 4 Mus musculus 185-189 30712820-6 2019 Seven compounds (tetrahydrocolumbamine, protopine, jatrorrhizine, glaucine, tetrahydropalmatine, palmatine, dehydrocorydaline) with high binding affinity to MAO-A were fished out from the ethyl acetate fraction extract of Corydalis Rhizome. jatrorrhizine 51-64 monoamine oxidase A Homo sapiens 157-162 30472912-3 2019 Based on our previous finding that jatrorrhizine was a potent inhibitor of OCT2 and OCT3, the aim of the present study was to explore whether jatrorrhizine has an antidepressant-like action action via inhibition of uptake-2 transporters. jatrorrhizine 142-155 POU domain, class 5, transcription factor 1 Mus musculus 84-88 30472912-5 2019 In vitro uptake tests showed that jatrorrhizine strongly inhibited PMAT-mediated MPP+ uptake with an IC50 value of 1.05 muM and reduced 5-HT and NE uptake mediated by hOCT2, hOCT3 and hPMAT with IC50 values of 0.1-1 muM (for OCT2 and OCT3) and 1-10 muM (for PMAT). jatrorrhizine 34-47 solute carrier family 29 (nucleoside transporters), member 4 Mus musculus 67-71 30472912-5 2019 In vitro uptake tests showed that jatrorrhizine strongly inhibited PMAT-mediated MPP+ uptake with an IC50 value of 1.05 muM and reduced 5-HT and NE uptake mediated by hOCT2, hOCT3 and hPMAT with IC50 values of 0.1-1 muM (for OCT2 and OCT3) and 1-10 muM (for PMAT). jatrorrhizine 34-47 POU class 2 homeobox 2 Homo sapiens 167-172 30472912-5 2019 In vitro uptake tests showed that jatrorrhizine strongly inhibited PMAT-mediated MPP+ uptake with an IC50 value of 1.05 muM and reduced 5-HT and NE uptake mediated by hOCT2, hOCT3 and hPMAT with IC50 values of 0.1-1 muM (for OCT2 and OCT3) and 1-10 muM (for PMAT). jatrorrhizine 34-47 POU class 5 homeobox 1 Homo sapiens 174-179 30472912-5 2019 In vitro uptake tests showed that jatrorrhizine strongly inhibited PMAT-mediated MPP+ uptake with an IC50 value of 1.05 muM and reduced 5-HT and NE uptake mediated by hOCT2, hOCT3 and hPMAT with IC50 values of 0.1-1 muM (for OCT2 and OCT3) and 1-10 muM (for PMAT). jatrorrhizine 34-47 solute carrier family 29 member 4 Homo sapiens 184-189 30472912-5 2019 In vitro uptake tests showed that jatrorrhizine strongly inhibited PMAT-mediated MPP+ uptake with an IC50 value of 1.05 muM and reduced 5-HT and NE uptake mediated by hOCT2, hOCT3 and hPMAT with IC50 values of 0.1-1 muM (for OCT2 and OCT3) and 1-10 muM (for PMAT). jatrorrhizine 34-47 POU domain, class 2, transcription factor 2 Mus musculus 168-172 31371920-0 2019 Jatrorrhizine inhibits colorectal carcinoma proliferation and metastasis through Wnt/beta-catenin signaling pathway and epithelial-mesenchymal transition. jatrorrhizine 0-13 catenin beta 1 Homo sapiens 85-97 29676131-9 2018 The protein expression levels of IRS2, PI3KR1, p-AKT (Ser473), p-AMPK (Thr172), GLUT4/1/2 were significantly up-regulated by different concentrations of jatrorrhizine and rosiglitazone (P<0.01). jatrorrhizine 153-166 insulin receptor substrate 2 Homo sapiens 33-37 29676131-9 2018 The protein expression levels of IRS2, PI3KR1, p-AKT (Ser473), p-AMPK (Thr172), GLUT4/1/2 were significantly up-regulated by different concentrations of jatrorrhizine and rosiglitazone (P<0.01). jatrorrhizine 153-166 solute carrier family 2 member 4 Homo sapiens 80-89 28780868-7 2017 Using this reference-free method based on CE-FA data, jatrorrhizine and palmatine were found to bind specifically to the Bcl-2 promoter G-quadruplex with stoichiometries of 4:1 and 3:1, respectively. jatrorrhizine 54-67 BCL2 apoptosis regulator Homo sapiens 121-126 29310241-0 2018 Hsa-miR-1587 G-quadruplex formation and dimerization induced by NH4+, molecular crowding environment and jatrorrhizine derivatives. jatrorrhizine 105-118 microRNA 1587 Homo sapiens 4-12 29310241-3 2018 Specifically, two synthesized jatrorrhizine derivatives with terminal amine groups could also induce the dimerization of miR-1587 G-quadruplex and formed 1:1 and 2:1 complexes with the dimeric G-quadruplex. jatrorrhizine 30-43 microRNA 1587 Homo sapiens 121-129 29310241-4 2018 In contrast, jatrorrhizine could bind with the dimeric miR-1587 G-quadruplex, but could not induce dimerization of miR-1587 G-quadruplex. jatrorrhizine 13-26 microRNA 1587 Homo sapiens 55-63 27565766-3 2017 The interaction mechanism between the G-quadruplex of KRAS promoter and three isoquinoline alkaloids (jatrorrhizine, berberine and sanguinarine) has been investigated by UV-visible, fluorescence and circular dichroism spectroscopic methods. jatrorrhizine 102-115 KRAS proto-oncogene, GTPase Homo sapiens 54-58 27565766-4 2017 The results showed that the three alkaloids can form complexes with G-quadruplex KRAS promoter with the molecular ratio of 1:1, and the binding constants were (0.90+-0.16)x106Lmol-1, (0.93+-0.21)x106Lmol-1 and (1.16+-0.45)x106Lmol-1 for jatrorrhizine, berberine and sanguinarine. jatrorrhizine 237-250 KRAS proto-oncogene, GTPase Homo sapiens 81-85 27401065-9 2017 Jatrorrhizine also attenuated the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons. jatrorrhizine 0-13 BCL2, apoptosis regulator Rattus norvegicus 47-52 27401065-9 2017 Jatrorrhizine also attenuated the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons. jatrorrhizine 0-13 BCL2 associated X, apoptosis regulator Rattus norvegicus 53-56 27401065-9 2017 Jatrorrhizine also attenuated the H2O2-induced Bcl-2/Bax ratio reduction and caspase-3 activation in these neurons. jatrorrhizine 0-13 caspase 3 Rattus norvegicus 77-86 28861978-5 2016 UGT1A1 activity was lowly inhibited by jatrorrhizine, with IC50 at about 227 mumol L-1, whereas coptisine and magnoflorine significantly activated UGT1A1. jatrorrhizine 39-52 UDP glucuronosyltransferase 1 family, polypeptide A1 Mus musculus 0-6 27878250-4 2017 Of the other agents, evodiamine was found to inhibit both IL-8 secretion and cell proliferation, and jatrorrhizine was found to increase IL-8 secretion without any obvious inhibitory effect on cell proliferation. jatrorrhizine 101-114 C-X-C motif chemokine ligand 8 Homo sapiens 137-141 26134304-7 2016 Additionally, coptisine, jatrorrhizine and epiberberine were substrates of all the hOCTs with the Km of 0.273-5.80 muM, whereas berberrubine was a substrate for hOCT1 and hOCT2, but not for hOCT3, the Km values were 1.27 and 1.66 muM, respectively. jatrorrhizine 25-38 solute carrier family 22 member 1 Homo sapiens 161-166 26134304-7 2016 Additionally, coptisine, jatrorrhizine and epiberberine were substrates of all the hOCTs with the Km of 0.273-5.80 muM, whereas berberrubine was a substrate for hOCT1 and hOCT2, but not for hOCT3, the Km values were 1.27 and 1.66 muM, respectively. jatrorrhizine 25-38 solute carrier family 22 member 2 Homo sapiens 171-176 26134304-10 2016 The above data indicate that the tested alkaloids are potent inhibitors, and coptisine, jatrorrhizine, epiberberine and berberrubine are substrates of hOCT1, hOCT2 and/or hOCT3 with high affinity. jatrorrhizine 88-101 solute carrier family 22 member 1 Homo sapiens 151-156 26134304-10 2016 The above data indicate that the tested alkaloids are potent inhibitors, and coptisine, jatrorrhizine, epiberberine and berberrubine are substrates of hOCT1, hOCT2 and/or hOCT3 with high affinity. jatrorrhizine 88-101 solute carrier family 22 member 2 Homo sapiens 158-163 26134304-10 2016 The above data indicate that the tested alkaloids are potent inhibitors, and coptisine, jatrorrhizine, epiberberine and berberrubine are substrates of hOCT1, hOCT2 and/or hOCT3 with high affinity. jatrorrhizine 88-101 solute carrier family 22 member 3 Homo sapiens 171-176 28861978-7 2016 According to the in vivo mice study, UGTs activity was significantly activated only in berberine group, while UGT1A1 activity was significantly activated only in jatrorrhizine group. jatrorrhizine 162-175 UDP glucuronosyltransferase 1 family, polypeptide A1 Mus musculus 110-116 24894270-6 2014 The results of qRT-PCR, western blotting and ELISA revealed that jatrorrhizine significantly up-regulated the mRNA and protein expression of LDLR and CYP7A1, but exhibited no significant effect on mRNA and protein expression of HMGR and ASBT in hamsters. jatrorrhizine 65-78 low-density lipoprotein receptor Mesocricetus auratus 141-145 24894270-7 2014 In conclusion, jatrorrhizine was a safe and potential antihypercholesterolemic agent from RC which could improve the utilization and excretion of cholesterol by up-regulating the mRNA and protein expression of LDLR and CYP7A1. jatrorrhizine 15-28 low-density lipoprotein receptor Mesocricetus auratus 210-214 23988532-0 2014 Exploring the site-selective binding of jatrorrhizine to human serum albumin: spectroscopic and molecular modeling approaches. jatrorrhizine 40-53 albumin Homo sapiens 63-76 24036307-0 2014 Spectroscopic analysis and molecular modeling on the interaction of jatrorrhizine with human serum albumin (HSA). jatrorrhizine 68-81 albumin Homo sapiens 93-106 24036307-1 2014 In this work, the interaction of jatrorrhizine with human serum albumin (HSA) was studied by means of UV-vis and fluorescence spectra. jatrorrhizine 33-46 albumin Homo sapiens 58-71 24236461-4 2014 Among different phyto-constituents, alkaloids that contain isoquinoline/bis(isoquinoline)and related ring structures (such as berberine, palmatine, coptisine, and jateorrhizine) have shown very potent aldose reductase inhibitory activity. jatrorrhizine 163-176 aldo-keto reductase family 1 member B Homo sapiens 201-217 23988532-1 2014 This paper exploring the site-selective binding of jatrorrhizine to human serum albumin (HSA) under physiological conditions (pH=7.4). jatrorrhizine 51-64 albumin Homo sapiens 74-87 23886934-0 2013 Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling. jatrorrhizine 48-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-18 24321576-7 2014 Four metabolites of BBR, jatrorrhizine, columbamine, berberrubine and demethyleneberberine, were found to be able to up-regulate LDLR mRNA and protein expression. jatrorrhizine 25-38 low density lipoprotein receptor Homo sapiens 129-133 24164032-7 2013 Seven isoquinoline alkaloids, namely jatrorrhizine, epiberberine, columbamine, coptisine, corysamine, palmatine and berberine were identified to be active as the inhibitors of ACHE. jatrorrhizine 37-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 23645029-0 2013 Biophysical studies on the interactions of jatrorrhizine with bovine serum albumin by spectroscopic and molecular modeling methods. jatrorrhizine 43-56 albumin Homo sapiens 69-82 23645029-1 2013 The interaction between jatrorrhizine (JAT) and bovine serum albumin (BSA) has been studied. jatrorrhizine 24-37 albumin Homo sapiens 55-68 23645029-1 2013 The interaction between jatrorrhizine (JAT) and bovine serum albumin (BSA) has been studied. jatrorrhizine 39-42 albumin Homo sapiens 55-68 23299247-7 2013 These results showed that jatrorrhizine is metabolized by human CYP1A2 and multiple UGT1A isoforms. jatrorrhizine 26-39 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 64-70 23299247-7 2013 These results showed that jatrorrhizine is metabolized by human CYP1A2 and multiple UGT1A isoforms. jatrorrhizine 26-39 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 84-89 23299247-2 2013 This study characterized the phase I and phase II metabolites, metabolic kinetics, and cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes responsible for the metabolism of jatrorrhizine in human liver microsomes (HLMs). jatrorrhizine 189-202 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 87-102 23299247-2 2013 This study characterized the phase I and phase II metabolites, metabolic kinetics, and cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes responsible for the metabolism of jatrorrhizine in human liver microsomes (HLMs). jatrorrhizine 189-202 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 104-107 23299247-2 2013 This study characterized the phase I and phase II metabolites, metabolic kinetics, and cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes responsible for the metabolism of jatrorrhizine in human liver microsomes (HLMs). jatrorrhizine 189-202 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 113-140 21645774-1 2011 The fluorescence spectra of berberine, palmatine, jatrorrhizine, and coptisine in ionic liquids were studied and found to increase significantly in ionic liquids, with [C(8)MIM][PF(6)] having the greatest increase. jatrorrhizine 50-63 sperm associated antigen 17 Homo sapiens 178-183 23299247-2 2013 This study characterized the phase I and phase II metabolites, metabolic kinetics, and cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes responsible for the metabolism of jatrorrhizine in human liver microsomes (HLMs). jatrorrhizine 189-202 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 142-145 22344858-4 2012 The metabolic kinetics, key cytochrome P450 enzymes and UDP-glucuronosyltransferase isoforms (UGTs) of jatrorrhizine were studied in rat liver microsomes (RLMs). jatrorrhizine 103-116 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 56-83 23280813-0 2013 Involvement of rat organic cation transporter 2 in the renal uptake of jatrorrhizine. jatrorrhizine 71-84 solute carrier family 22 member 2 Rattus norvegicus 19-47 23280813-2 2013 In the present study, the involvement of rat organic cation transporter 2 (rOCT2) in the renal uptake of jatrorrhizine in rat was investigated through in vitro and in vivo experiments. jatrorrhizine 105-118 solute carrier family 22 member 2 Rattus norvegicus 45-73 23280813-2 2013 In the present study, the involvement of rat organic cation transporter 2 (rOCT2) in the renal uptake of jatrorrhizine in rat was investigated through in vitro and in vivo experiments. jatrorrhizine 105-118 solute carrier family 22 member 2 Rattus norvegicus 75-80 23280813-3 2013 Saturable and nonsaturable uptakes of jatrorrhizine were observed in rat kidney slices and rOCT2-Madin-Darby canine kidney (MDCK) cells. jatrorrhizine 38-51 solute carrier family 22 member 2 Rattus norvegicus 91-96 23280813-5 2013 As inhibitors of rOCT2, corticosterone, verapamil, and cimetidine can inhibit jatrorrhizine uptake in rat kidney slices and rOCT2-MDCK cells. jatrorrhizine 78-91 solute carrier family 22 member 2 Rattus norvegicus 17-22 23280813-7 2013 Coadministration with 20 mg/kg corticosterone, a selective inhibitor of rOCT2, reduced the jatrorrhizine concentration in the cortex and medulla in the in vivo experiment. jatrorrhizine 91-104 solute carrier family 22 member 2 Rattus norvegicus 72-77 23280813-8 2013 Thus, rOCT2 is mainly responsible for the renal uptake of jatrorrhizine in rat and in the regulation of jatrorrhizine concentration in the kidney. jatrorrhizine 58-71 solute carrier family 22 member 2 Rattus norvegicus 6-11 23280813-8 2013 Thus, rOCT2 is mainly responsible for the renal uptake of jatrorrhizine in rat and in the regulation of jatrorrhizine concentration in the kidney. jatrorrhizine 104-117 solute carrier family 22 member 2 Rattus norvegicus 6-11 21605627-4 2011 Preincubation of cells with Jatrorrhizine (0.01-10.0 muM) 24h prior to H(2)O(2) exposure markedly elevated cell viability and activities of antioxidant enzyme (SOD and HO-1), prevented LDH release and lipid peroxidation (MDA) production, attenuated the decrease of MMP and scavenged ROS formation. jatrorrhizine 28-41 heme oxygenase 1 Rattus norvegicus 168-172 21605627-5 2011 Jatrorrhizine also attenuated caspase-3 activation of the downstream cascade following ROS. jatrorrhizine 0-13 caspase 3 Rattus norvegicus 30-39 21319959-8 2011 Berberine, palmatine, jateorhizine, and coptisine were all P-gp substrates; and at the range of 1-100 muM, berberine, palmatine, jateorhizine, and coptisine had no inhibitory effects on P-gp. jatrorrhizine 22-34 ATP binding cassette subfamily B member 1 Homo sapiens 59-63 19472295-3 2009 The results revealed that PD, anemonin, berberine, and esculetin inhibited the production of NO; PD, anemonin, and esculetin inhibited the secretion of ET-1; PD, anemoside B(4), berberine, jatrorrhizine, and aesculin downregulated TNF-alpha expression; PD, anemoside B(4), berberine, and palmatine decreased the content of IL-1 alpha. jatrorrhizine 189-202 endothelin 1 Rattus norvegicus 152-156 19431018-1 2009 By introducing octyloxy to C-3 and alkyl groups to C-8 of jatrorrhizine, a series of 3-octyloxy-8-alkyljatrorrhizine derivatives were synthesized and their antimicrobial activities were evaluated in vitro. jatrorrhizine 58-71 homeobox C8 Homo sapiens 51-54 15807993-4 2005 In addition, DNA fragmentation induced by SIN-1 was significantly decreased by the extract, and also by coptisine, epiberberine, jatrorhizine, groenlandicine and magnoflorine. jatrorrhizine 129-141 MAPK associated protein 1 Homo sapiens 42-47 16463653-6 2005 It was found that Jat (50 mg/kg, 100 mg/kg) could significantly decrease blood glucose level in a dose- and time-dependent manner in both normal and alloxan-diabetic mice, increase the activity of SDH, but had no significant effects on the LC level and LDH activity. jatrorrhizine 18-21 aminoadipate-semialdehyde synthase Mus musculus 197-200 15715992-0 2005 Binding of the bioactive component jatrorrhizine to human serum albumin. jatrorrhizine 35-48 albumin Homo sapiens 58-71 15715992-1 2005 The interaction between Jatrorrhizine with human serum albumin (HSA) were studied by fluorescence quenching technique, circular dichroism (CD) spectroscopy, and Fourier transform infrared (FT-IR) spectroscopy. jatrorrhizine 24-37 albumin Homo sapiens 49-62 11270727-2 2001 Jatrorrhizine was shown to inhibit non-competitively both MAO-A and -B from rat brain mitochondria with the IC50 values of 4 and 62 microM, respectively. jatrorrhizine 0-13 monoamine oxidase A Rattus norvegicus 58-70